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Patent code US9730937

Compile Data Set for Download or QSAR

Found 1155 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333642
PNG
(1-[5-(1,3- difluoro-2- methylpropan- 2- yl)isoxazo...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(CF)CF)c3)c2cc1OC
Show InChI InChI=1S/C24H23F2N5O4S/c1-24(11-25,12-26)20-10-21(31-35-20)30-23(32)29-14-5-4-6-15(7-14)36-22-16-8-18(33-2)19(34-3)9-17(16)27-13-28-22/h4-10,13H,11-12H2,1-3H3,(H2,29,30,31,32)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333645
PNG
(1-[3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)NC4=CC(=[N](C)N4)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C22H20F3N6O3S/c1-31-18(22(23,24)25)10-19(30-31)29-21(32)28-12-5-4-6-13(7-12)35-20-14-8-16(33-2)17(34-3)9-15(14)26-11-27-20/h4-11,30H,1-3H3,(H2,28,29,32)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333646
PNG
(US9730937, Example 195 | ethyl 2-(3- tert-butyl-5-...)
Show SMILES CCOC(=O)Cn1nc(cc1NC(=O)Nc1cccc(Sc2ncnc3cc(OC)c(OC)cc23)c1)C(C)(C)C
Show InChI InChI=1S/C28H32N6O5S/c1-7-39-25(35)15-34-24(14-23(33-34)28(2,3)4)32-27(36)31-17-9-8-10-18(11-17)40-26-19-12-21(37-5)22(38-6)13-20(19)29-16-30-26/h8-14,16H,7,15H2,1-6H3,(H2,31,32,36)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333651
PNG
(1-(3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl...)
Show SMILES COCCOc1cc(NC(=O)Nc2cccc(Sc3ncnc4cc(OC)c(OC)cc34)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H25F3N4O5S/c1-36-7-8-39-19-10-16(27(28,29)30)9-18(11-19)34-26(35)33-17-5-4-6-20(12-17)40-25-21-13-23(37-2)24(38-3)14-22(21)31-15-32-25/h4-6,9-15H,7-8H2,1-3H3,(H2,33,34,35)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333510
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-{3- [6-methoxy- ...)
Show SMILES COCCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5S/c1-26(2,3)22-14-23(31-36-22)30-25(32)29-16-7-6-8-17(11-16)37-24-18-12-20(34-5)21(35-10-9-33-4)13-19(18)27-15-28-24/h6-8,11-15H,9-10H2,1-5H3,(H2,29,30,31,32)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333512
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-[3- (7,8-dihydro...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Sc3ncnc4cc5OCCOc5cc34)c2)no1
Show InChI InChI=1S/C24H23N5O4S/c1-24(2,3)20-12-21(29-33-20)28-23(30)27-14-5-4-6-15(9-14)34-22-16-10-18-19(32-8-7-31-18)11-17(16)25-13-26-22/h4-6,9-13H,7-8H2,1-3H3,(H2,27,28,29,30)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333513
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-{3- [7-methoxy- ...)
Show SMILES COc1cc(OC2CCOCC2)c2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2c1
Show InChI InChI=1S/C28H31N5O5S/c1-28(2,3)23-15-24(33-38-23)32-27(34)31-17-6-5-7-20(12-17)39-26-25-21(29-16-30-26)13-19(35-4)14-22(25)37-18-8-10-36-11-9-18/h5-7,12-16,18H,8-11H2,1-4H3,(H2,31,32,33,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333514
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Show SMILES CCOc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC
Show InChI InChI=1S/C25H27N5O4S/c1-6-33-20-11-17-18(12-19(20)32-5)26-14-27-23(17)35-16-9-7-8-15(10-16)28-24(31)29-22-13-21(34-30-22)25(2,3)4/h7-14H,6H2,1-5H3,(H2,28,29,30,31)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333518
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H39N7O4S/c1-31(2,3)27-19-28(36-42-27)35-30(39)34-21-8-6-9-22(16-21)43-29-23-17-26(25(40-5)18-24(23)32-20-33-29)41-15-7-10-38-13-11-37(4)12-14-38/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333519
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoixy-...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H39N7O6S2/c1-31(2,3)27-19-28(36-44-27)35-30(39)34-21-8-6-9-22(16-21)45-29-23-17-26(25(42-4)18-24(23)32-20-33-29)43-15-7-10-37-11-13-38(14-12-37)46(5,40)41/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333519
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoixy-...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H39N7O6S2/c1-31(2,3)27-19-28(36-44-27)35-30(39)34-21-8-6-9-22(16-21)45-29-23-17-26(25(42-4)18-24(23)32-20-33-29)43-15-7-10-37-11-13-38(14-12-37)46(5,40)41/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333525
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(2-(4- (h...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCC(CO)CC1
Show InChI InChI=1S/C31H38N6O5S/c1-31(2,3)27-17-28(36-42-27)35-30(39)34-21-6-5-7-22(14-21)43-29-23-15-26(25(40-4)16-24(23)32-19-33-29)41-13-12-37-10-8-20(18-38)9-11-37/h5-7,14-17,19-20,38H,8-13,18H2,1-4H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333654
PNG
(1-(3-(6- Methoxy-7- (2- methoxyethoxy) quinazolin-...)
Show SMILES COCCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)-c4ccccc4)c3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5S/c1-35-11-12-37-25-15-22-21(14-24(25)36-2)27(30-17-29-22)39-20-10-6-9-19(13-20)31-28(34)32-26-16-23(38-33-26)18-7-4-3-5-8-18/h3-10,13-17H,11-12H2,1-2H3,(H2,31,32,33,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333713
PNG
(1-(3-(7- hydroxy-6- methoxy- quinazolin- 4- yloxy)...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)ncnc2cc1O
Show InChI InChI=1S/C23H20F3N5O5/c1-22(2,23(24,25)26)18-10-19(31-36-18)30-21(33)29-12-5-4-6-13(7-12)35-20-14-8-17(34-3)16(32)9-15(14)27-11-28-20/h4-11,32H,1-3H3,(H2,29,30,31,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333714
PNG
(1-(3-(6- hydroxy-7- methoxy- quinazolin- 4- yloxy)...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1O
Show InChI InChI=1S/C23H20F3N5O5/c1-22(2,23(24,25)26)18-10-19(31-36-18)30-21(33)29-12-5-4-6-13(7-12)35-20-14-8-16(32)17(34-3)9-15(14)27-11-28-20/h4-11,32H,1-3H3,(H2,29,30,31,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333715
PNG
(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)-2- flu...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3F)c2cc1OC
Show InChI InChI=1S/C24H21F4N5O5/c1-23(2,24(26,27)28)18-10-19(33-38-18)32-22(34)31-13-6-5-7-15(20(13)25)37-21-12-8-16(35-3)17(36-4)9-14(12)29-11-30-21/h5-11H,1-4H3,(H2,31,32,33,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333717
PNG
(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C(C)(C)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(37-32-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333718
PNG
(1-(3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(no4)C(C)(C)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C24H22F3N5O4S/c1-23(2,24(25,26)27)19-11-20(36-32-19)31-22(33)30-13-6-5-7-14(8-13)37-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333724
PNG
(1-(3-tert- butyl-1-p- tolyl-1H- pyrazol-5-yl)- 3-(...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c3)c2cc1OC
Show InChI InChI=1S/C31H32N6O4/c1-19-10-12-21(13-11-19)37-28(17-27(36-37)31(2,3)4)35-30(38)34-20-8-7-9-22(14-20)41-29-23-15-25(39-5)26(40-6)16-24(23)32-18-33-29/h7-18H,1-6H3,(H2,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333724
PNG
(1-(3-tert- butyl-1-p- tolyl-1H- pyrazol-5-yl)- 3-(...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c3)c2cc1OC
Show InChI InChI=1S/C31H32N6O4/c1-19-10-12-21(13-11-19)37-28(17-27(36-37)31(2,3)4)35-30(38)34-20-8-7-9-22(14-20)41-29-23-15-25(39-5)26(40-6)16-24(23)32-18-33-29/h7-18H,1-6H3,(H2,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333726
PNG
(1-(3-tert- butyl-1-p- tolyl-1H- pyrazol-5-yl)- 3-(...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c3)c2cc1OC
Show InChI InChI=1S/C33H36N6O5/c1-21-10-12-23(13-11-21)39-30(19-29(38-39)33(2,3)4)37-32(40)36-22-8-7-9-24(16-22)44-31-25-17-27(42-6)28(43-15-14-41-5)18-26(25)34-20-35-31/h7-13,16-20H,14-15H2,1-6H3,(H2,36,37,40)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333728
PNG
(1-(3-(2-cyano- propan- 2- yl)phenyl)-3- (3-(6,7- d...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cccc(c4)C(C)(C)C#N)c3)c2cc1OC
Show InChI InChI=1S/C27H25N5O4/c1-27(2,15-28)17-7-5-8-18(11-17)31-26(33)32-19-9-6-10-20(12-19)36-25-21-13-23(34-3)24(35-4)14-22(21)29-16-30-25/h5-14,16H,1-4H3,(H2,31,32,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333526
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCN(C)CC1
Show InChI InChI=1S/C30H37N7O4S/c1-30(2,3)26-18-27(35-41-26)34-29(38)33-20-7-6-8-21(15-20)42-28-22-16-25(24(39-5)17-23(22)31-19-32-28)40-14-13-37-11-9-36(4)10-12-37/h6-8,15-19H,9-14H2,1-5H3,(H2,33,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333528
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H37N7O6S2/c1-30(2,3)26-18-27(35-43-26)34-29(38)33-20-7-6-8-21(15-20)44-28-22-16-25(24(41-4)17-23(22)31-19-32-28)42-14-13-36-9-11-37(12-10-36)45(5,39)40/h6-8,15-19H,9-14H2,1-5H3,(H2,33,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333532
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H39N7O4S/c1-31(2,3)27-19-28(36-42-27)35-30(39)34-21-8-6-9-22(16-21)43-29-23-17-25(40-5)26(18-24(23)32-20-33-29)41-15-7-10-38-13-11-37(4)12-14-38/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333533
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(3-(4- (h...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C32H40N6O5S/c1-32(2,3)28-18-29(37-43-28)36-31(40)35-22-7-5-8-23(15-22)44-30-24-16-26(41-4)27(17-25(24)33-20-34-30)42-14-6-11-38-12-9-21(19-39)10-13-38/h5,7-8,15-18,20-21,39H,6,9-14,19H2,1-4H3,(H2,35,36,37,40)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333537
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCOCC1
Show InChI InChI=1S/C29H34N6O5S/c1-29(2,3)25-17-26(34-40-25)33-28(36)32-19-6-5-7-20(14-19)41-27-21-15-23(37-4)24(16-22(21)30-18-31-27)39-13-10-35-8-11-38-12-9-35/h5-7,14-18H,8-13H2,1-4H3,(H2,32,33,34,36)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333538
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C30H36N6O4S/c1-30(2,3)26-18-27(35-40-26)34-29(37)33-20-9-8-10-21(15-20)41-28-22-16-24(38-4)25(17-23(22)31-19-32-28)39-14-13-36-11-6-5-7-12-36/h8-10,15-19H,5-7,11-14H2,1-4H3,(H2,33,34,35,37)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333539
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H37N7O6S2/c1-30(2,3)26-18-27(35-43-26)34-29(38)33-20-7-6-8-21(15-20)44-28-22-16-24(41-4)25(17-23(22)31-19-32-28)42-14-13-36-9-11-37(12-10-36)45(5,39)40/h6-8,15-19H,9-14H2,1-5H3,(H2,33,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333658
PNG
(1-{3-[6- methoxy-7- (2- methoxyethoxy) quinazolin-...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(n(C)n4)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C24H23F3N6O5/c1-33-20(24(25,26)27)12-21(32-33)31-23(34)30-14-5-4-6-15(9-14)38-22-16-10-18(36-3)19(37-8-7-35-2)11-17(16)28-13-29-22/h4-6,9-13H,7-8H2,1-3H3,(H2,30,31,32,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333658
PNG
(1-{3-[6- methoxy-7- (2- methoxyethoxy) quinazolin-...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(n(C)n4)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C24H23F3N6O5/c1-33-20(24(25,26)27)12-21(32-33)31-23(34)30-14-5-4-6-15(9-14)38-22-16-10-18(36-3)19(37-8-7-35-2)11-17(16)28-13-29-22/h4-6,9-13H,7-8H2,1-3H3,(H2,30,31,32,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333661
PNG
(1-(3-(1,1- difluoroethyl) isoxazol- 5- yl)-3-(3-(6...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C(C)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C24H23F2N5O6/c1-24(25,26)20-12-21(37-31-20)30-23(32)29-14-5-4-6-15(9-14)36-22-16-10-18(34-3)19(35-8-7-33-2)11-17(16)27-13-28-22/h4-6,9-13H,7-8H2,1-3H3,(H2,29,30,32)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333663
PNG
(1-[5-(1,3- difluoro-2- methylpropan-2- yl)isoxazol...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(CF)CF)c3)c2cc1OC
Show InChI InChI=1S/C26H27F2N5O6/c1-26(13-27,14-28)22-12-23(33-39-22)32-25(34)31-16-5-4-6-17(9-16)38-24-18-10-20(36-3)21(37-8-7-35-2)11-19(18)29-15-30-24/h4-6,9-12,15H,7-8,13-14H2,1-3H3,(H2,31,32,33,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333664
PNG
(1-(3- cyclopropyl- isoxazol- 5- yl)-3-(3-(6- metho...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C4CC4)c3)c2cc1OC
Show InChI InChI=1S/C25H25N5O6/c1-32-8-9-34-22-12-20-18(11-21(22)33-2)24(27-14-26-20)35-17-5-3-4-16(10-17)28-25(31)29-23-13-19(30-36-23)15-6-7-15/h3-5,10-15H,6-9H2,1-2H3,(H2,28,29,31)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333665
PNG
(1-(3- isopropylisoxazol- 5-yl)- 3-(3-(6-methoxy- 7...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C(C)C)c3)c2cc1OC
Show InChI InChI=1S/C25H27N5O6/c1-15(2)19-13-23(36-30-19)29-25(31)28-16-6-5-7-17(10-16)35-24-18-11-21(33-4)22(34-9-8-32-3)12-20(18)26-14-27-24/h5-7,10-15H,8-9H2,1-4H3,(H2,28,29,31)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333666
PNG
(1-(3-(6- methoxy-7-(2- methoxyethoxy) quinazolin-4...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C4CCOCC4)c3)c2cc1OC
Show InChI InChI=1S/C27H29N5O7/c1-34-10-11-37-24-14-22-20(13-23(24)35-2)26(29-16-28-22)38-19-5-3-4-18(12-19)30-27(33)31-25-15-21(32-39-25)17-6-8-36-9-7-17/h3-5,12-17H,6-11H2,1-2H3,(H2,30,31,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333667
PNG
(1-(5-(1- methoxy-2- methylpropan-2- yl)isoxazol- 3...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C(C)(C)COC)c3)c2cc1OC
Show InChI InChI=1S/C27H31N5O7/c1-27(2,15-35-4)23-14-24(39-32-23)31-26(33)30-17-7-6-8-18(11-17)38-25-19-12-21(36-5)22(37-10-9-34-3)13-20(19)28-16-29-25/h6-8,11-14,16H,9-10,15H2,1-5H3,(H2,30,31,33)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333669
PNG
(1-(5- cyclopentyl- isoxazol- 3-yl)- 3-(3-(6- metho...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C4CCCC4)c3)c2cc1OC
Show InChI InChI=1S/C27H29N5O6/c1-34-10-11-36-24-14-21-20(13-23(24)35-2)26(29-16-28-21)37-19-9-5-8-18(12-19)30-27(33)31-25-15-22(38-32-25)17-6-3-4-7-17/h5,8-9,12-17H,3-4,6-7,10-11H2,1-2H3,(H2,30,31,32,33)
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AMBIT BIOSCIENCES CORPORATION

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Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333692
PNG
(1-[1-(4- fluorophenyl)-3- (trifluoromethyl)- 1H- p...)
Show SMILES COCCOc1cc2ncnc(Sc3cccc(NC(=O)NC4=CC(=NC4c4ccc(F)cc4)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C30H25F4N5O4S/c1-41-10-11-43-25-14-22-21(13-24(25)42-2)28(36-16-35-22)44-20-5-3-4-19(12-20)37-29(40)38-23-15-26(30(32,33)34)39-27(23)17-6-8-18(31)9-7-17/h3-9,12-16,27H,10-11H2,1-2H3,(H2,37,38,40)
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333543
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(2- metho...)
Show SMILES COCCOc1ccc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2c1
Show InChI InChI=1S/C25H27N5O4S/c1-25(2,3)21-14-22(30-34-21)29-24(31)28-16-6-5-7-18(12-16)35-23-19-13-17(33-11-10-32-4)8-9-20(19)26-15-27-23/h5-9,12-15H,10-11H2,1-4H3,(H2,28,29,30,31)
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333547
PNG
(1-(5-tert- Butyl- isoxazol-3- yl)-3-(3-{6- [2-(1,1...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCS(=O)(=O)CC1
Show InChI InChI=1S/C29H34N6O7S/c1-29(2,3)25-17-26(34-42-25)33-28(36)32-19-6-5-7-20(14-19)41-27-21-15-24(23(39-4)16-22(21)30-18-31-27)40-11-8-35-9-12-43(37,38)13-10-35/h5-7,14-18H,8-13H2,1-4H3,(H2,32,33,34,36)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333548
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-{3- [6-(5-{[2- (...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3ncnc4ccc(cc34)-c3ccc(CNCCS(C)(=O)=O)o3)c2)no1
Show InChI InChI=1S/C30H32N6O6S/c1-30(2,3)26-16-27(36-42-26)35-29(37)34-20-6-5-7-21(15-20)41-28-23-14-19(8-10-24(23)32-18-33-28)25-11-9-22(40-25)17-31-12-13-43(4,38)39/h5-11,14-16,18,31H,12-13,17H2,1-4H3,(H2,34,35,36,37)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333554
PNG
((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-metho...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1O[C@@H]1CCN(C)C1
Show InChI InChI=1S/C28H32N6O5/c1-28(2,3)24-14-25(33-39-24)32-27(35)31-17-7-6-8-18(11-17)38-26-20-12-22(36-5)23(13-21(20)29-16-30-26)37-19-9-10-34(4)15-19/h6-8,11-14,16,19H,9-10,15H2,1-5H3,(H2,31,32,33,35)/t19-/m1/s1
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333555
PNG
((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(2- h...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC[C@H](O)CN1CCN(C)CC1
Show InChI InChI=1S/C31H39N7O6/c1-31(2,3)27-16-28(36-44-27)35-30(40)34-20-7-6-8-22(13-20)43-29-23-14-25(41-5)26(15-24(23)32-19-33-29)42-18-21(39)17-38-11-9-37(4)10-12-38/h6-8,13-16,19,21,39H,9-12,17-18H2,1-5H3,(H2,34,35,36,40)/t21-/m1/s1
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333556
PNG
(1-(3-tert- Butylisoxazol- 5-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C29H34N6O5/c1-29(2,3)25-15-26(35-40-25)34-28(36)33-19-6-5-7-20(12-19)39-27-21-13-23(37-4)24(14-22(21)31-17-32-27)38-16-18-8-10-30-11-9-18/h5-7,12-15,17-18,30H,8-11,16H2,1-4H3,(H2,33,34,35,36)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333557
PNG
(1-(3-tert- butylisoxazol- 5-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C30H36N6O5/c1-30(2,3)26-16-27(35-41-26)34-29(37)33-20-7-6-8-21(13-20)40-28-22-14-24(38-5)25(15-23(22)31-18-32-28)39-17-19-9-11-36(4)12-10-19/h6-8,13-16,18-19H,9-12,17H2,1-5H3,(H2,33,34,35,37)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333559
PNG
((S)-1-(5-tert- Butylisoxazol- 3-yl)-3-(3- {6-metho...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1O[C@H]1CCN(CC(F)(F)F)C1
Show InChI InChI=1S/C29H31F3N6O5/c1-28(2,3)24-13-25(37-43-24)36-27(39)35-17-6-5-7-18(10-17)42-26-20-11-22(40-4)23(12-21(20)33-16-34-26)41-19-8-9-38(14-19)15-29(30,31)32/h5-7,10-13,16,19H,8-9,14-15H2,1-4H3,(H2,35,36,37,39)/t19-/m0/s1
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333679
PNG
(1-(3-(6- methoxy-7- (2- methoxyethoxy) quinazolin-...)
Show SMILES COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(no4)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C23H20F3N5O6/c1-33-6-7-35-18-10-16-15(9-17(18)34-2)21(28-12-27-16)36-14-5-3-4-13(8-14)29-22(32)30-20-11-19(31-37-20)23(24,25)26/h3-5,8-12H,6-7H2,1-2H3,(H2,29,30,32)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333685
PNG
(1-(5- cyclopentyl- isoxazol- 3- yl)-3-(3-(6- metho...)
Show SMILES COCCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C4CCCC4)c3)c2cc1OC
Show InChI InChI=1S/C27H29N5O5S/c1-34-10-11-36-24-14-21-20(13-23(24)35-2)26(29-16-28-21)38-19-9-5-8-18(12-19)30-27(33)31-25-15-22(37-32-25)17-6-3-4-7-17/h5,8-9,12-17H,3-4,6-7,10-11H2,1-2H3,(H2,30,31,32,33)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333697
PNG
(1-(3-(6,7-bis(2- Methoxyethoxy) quinazolin-4- ylth...)
Show SMILES COCCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(no4)C(C)(C)C)c3)c2cc1OCCOC
Show InChI InChI=1S/C28H33N5O6S/c1-28(2,3)24-16-25(39-33-24)32-27(34)31-18-7-6-8-19(13-18)40-26-20-14-22(37-11-9-35-4)23(38-12-10-36-5)15-21(20)29-17-30-26/h6-8,13-17H,9-12H2,1-5H3,(H2,31,32,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
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