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Patent code US9730939

Compile Data Set for Download or QSAR

Found 366 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255790
PNG
(1-{1-[5-Chloro-3-(1-isopropylazetidin-3-yl)-2-meth...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O/c1-11(2)28-8-15(9-28)18-12(3)17(23)7-16(20(18)30-6)14(5)29-22-19(13(4)27-29)21(24)25-10-26-22/h7,10-11,14-15H,8-9H2,1-6H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255793
PNG
(1-(1-{5-Chloro-3-[1-(cyclopropylmethyl)azetidin-3-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O/c1-12-18(24)7-17(14(3)30-23-20(13(2)28-30)22(25)26-11-27-23)21(31-4)19(12)16-9-29(10-16)8-15-5-6-15/h7,11,14-16H,5-6,8-10H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255811
PNG
(3′-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(C(=O)N(C)C)c(F)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClFN6O2/c1-12-18(26)10-17(14(3)33-24-21(13(2)31-33)23(28)29-11-30-24)22(35-6)20(12)15-7-8-16(19(27)9-15)25(34)32(4)5/h7-11,14H,1-6H3,(H2,28,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289024
PNG
(US10092570, Example 25 | US9730939, Example 25)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN6O3/c1-13-17(26)10-16(14(2)32-9-8-19(33)21-23(27)29-12-30-24(21)32)22(35-5)20(13)15-6-7-18(28-11-15)25(34)31(3)4/h6-12,14H,1-5H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255847
PNG
(5-{4-amino-1-[1-(5-chloro-3-{6-[(dimethylamino)car...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccc(nc2)C(=O)N(C)C)c2c(N)ncnc12
Show InChI InChI=1S/C32H34ClN9O3/c1-8-45-28-21(13-22(33)17(2)25(28)19-9-11-23(35-14-19)31(43)40(4)5)18(3)42-30-26(29(34)37-16-38-30)27(39-42)20-10-12-24(36-15-20)32(44)41(6)7/h9-16,18H,8H2,1-7H3,(H2,34,37,38)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255859
PNG
(US10092570, Example 68 | US9707233, 68 (1st peak) ...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM333915
PNG
((2R)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(F)c(F)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26F2N6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m1/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261059
PNG
(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClF2N7O2/c1-6-37-21-15(13(3)35-24-19(20(33-35)22(27)28)23(29)31-11-32-24)9-16(26)12(2)18(21)14-7-8-17(30-10-14)25(36)34(4)5/h7-11,13,22H,6H2,1-5H3,(H2,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261060
PNG
(5-(3-{1-[4-Amino-3-(hydroxymethyl)-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CO)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-6-36-22-16(14(3)33-24-21(19(11-34)31-33)23(27)29-12-30-24)9-17(26)13(2)20(22)15-7-8-18(28-10-15)25(35)32(4)5/h7-10,12,14,34H,6,11H2,1-5H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261088
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(N)=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClN7O2/c1-10-15(22)5-14(19(31-4)17(10)13-6-28(7-13)8-16(23)30)12(3)29-21-18(11(2)27-29)20(24)25-9-26-21/h5,9,12-13H,6-8H2,1-4H3,(H2,23,30)(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261091
PNG
(1-(1-{5-Chloro-3-[1-(2-fluoro-1- methylethyl)azeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)CF)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O/c1-11(7-24)29-8-15(9-29)18-12(2)17(23)6-16(20(18)31-5)14(4)30-22-19(13(3)28-30)21(25)26-10-27-22/h6,10-11,14-15H,7-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261098
PNG
((2R)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H27ClN6O3/c1-10-16(23)6-15(12(3)29-21-18(11(2)27-29)20(24)25-9-26-21)19(32-5)17(10)14-7-28(8-14)22(31)13(4)30/h6,9,12-14,30H,7-8H2,1-5H3,(H2,24,25,26)/t12?,13-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261100
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-6)17(11)14-8-29(9-14)22(31)23(4,5)32/h7,10,13-14,32H,8-9H2,1-6H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261113
PNG
(5-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(CC(F)F)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H23F4N7O/c1-10-12(5-27)4-14(19(34-3)16(10)13-6-32(7-13)8-15(23)24)11(2)33-22-17(18(31-33)20(25)26)21(28)29-9-30-22/h4,9,11,13,15,20H,6-8H2,1-3H3,(H2,28,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261119
PNG
((2R)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m1/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261140
PNG
(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O/c1-12-17(23)10-16(20(30-5)18(12)15-6-8-28(4)9-7-15)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h10-11,14-15H,6-9H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261146
PNG
(1-(1-(3-(2-aminopyrimidin-5-yl)-5- chloro-2-methox...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnc(N)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21ClN8O/c1-9-14(21)5-13(17(30-4)15(9)12-6-24-20(23)25-7-12)11(3)29-19-16(10(2)28-29)18(22)26-8-27-19/h5-8,11H,1-4H3,(H2,22,26,27)(H2,23,24,25)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261154
PNG
(1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CC(C1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H25ClN8O2/c1-13-20(27)6-19(15(3)35-25-22(14(2)33-35)24(29)31-12-32-25)23(37-4)21(13)17-5-18(9-30-8-17)26(36)34-10-16(7-28)11-34/h5-6,8-9,12,15-16H,10-11H2,1-4H3,(H2,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261158
PNG
(1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261167
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC1CC1
Show InChI InChI=1S/C27H32ClN7O2/c1-14-20(28)10-19(16(3)34-26-23(15(2)29)25(30)32-13-33-26)24(37-12-17-6-7-17)22(14)18-8-9-21(31-11-18)27(36)35(4)5/h8-11,13,16-17,29H,6-7,12H2,1-5H3,(H3,30,32,33,34)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261174
PNG
(1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(1-methyl-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-6-30-19-15(7-16(22)11(2)17(19)14-8-26-28(5)9-14)13(4)29-21-18(12(3)27-29)20(23)24-10-25-21/h7-10,13H,6H2,1-5H3,(H2,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261180
PNG
(2-(4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C22H27ClN8O2/c1-5-33-20-15(13(4)30-22-19(12(3)24)21(26)27-10-28-22)6-16(23)11(2)18(20)14-7-29-31(8-14)9-17(25)32/h6-8,10,13,24H,5,9H2,1-4H3,(H2,25,32)(H3,26,27,28,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334069
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334069
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334088
PNG
(2-(1-Acetylazetidin-3-yl)-4-[1-(4- amino-3-methami...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)=O)C(C)N1NC(C)(C)c2c1nc(N)nc2N
Show InChI InChI=1S/C23H29ClN8O2/c1-6-34-19-14(7-16(24)15(8-25)17(19)13-9-31(10-13)12(3)33)11(2)32-21-18(23(4,5)30-32)20(26)28-22(27)29-21/h7,11,13,30H,6,9-10H2,1-5H3,(H4,26,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261220
PNG
(US10092570, Example 243 | US9707233, 243 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)CC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O2/c1-5-18(32)30-9-14(10-30)20-16(8-25)17(24)7-15(21(20)33-6-2)13(4)31-23-19(12(3)29-31)22(26)27-11-28-23/h7,11,13-14H,5-6,9-10H2,1-4H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261225
PNG
(US10092570, Example 248 | US9707233, 248 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O3S/c1-5-32-19-14(12(3)29-21-17(11(2)27-29)20(24)25-10-26-21)6-16(22)15(7-23)18(19)13-8-28(9-13)33(4,30)31/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261229
PNG
(US10092570, Example 252 | US9707233, 252 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O3/c1-5-33-19-14(12(3)30-21-17(11(2)28-30)20(25)26-10-27-21)6-16(23)15(7-24)18(19)13-8-29(9-13)22(31)32-4/h6,10,12-13H,5,8-9H2,1-4H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261231
PNG
(US10092570, Example 254 | US9707233, 254 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O3/c1-6-34-21-16(14(5)32-23-19(13(4)30-32)22(27)28-11-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)24(33)35-12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261238
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CNC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClN7O/c1-9-15-18(22)24-8-25-19(15)27(26-9)10(2)12-4-14(20)13(5-21)16(17(12)28-3)11-6-23-7-11/h4,8,10-11,23H,6-7H2,1-3H3,(H2,22,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334118
PNG
(Diastereoisomers of 4-[1-(4-amino-3-methyl-1H-pyra...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(9-31)29-7-14(8-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261258
PNG
(2-(1-Acetylazetidin-3-yl)-4-[1-(4-amino-3-methyl-1...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-10-17-20(24)25-9-26-21(17)29(27-10)11(2)14-5-16(22)15(6-23)18(19(14)31-4)13-7-28(8-13)12(3)30/h5,9,11,13H,7-8H2,1-4H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289304
PNG
((3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyri...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21Cl2N7O/c1-10-15-19(24)25-9-26-20(15)29(27-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-28(8-12)5-4-23/h6,9,11-12H,5,7-8H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261290
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN7O2/c1-6-35-22-16(14(3)33-24-20(13(2)32-33)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(4,5)34/h7-9,11-12,14,34H,6H2,1-5H3,(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261312
PNG
(US10092570, Example 341 | US9707233, 341 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CC(COC)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-5-32-20-15(13(3)30-22-18(12(2)28-30)21(25)26-11-27-22)6-17(23)16(7-24)19(20)29-8-14(9-29)10-31-4/h6,11,13-14H,5,8-10H2,1-4H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261314
PNG
(US9707233, 343 | US9730939, Example 343)
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24N8O/c1-6-31-20-16(7-12(2)17(8-23)19(20)15-9-27-29(5)10-15)14(4)30-22-18(13(3)28-30)21(24)25-11-26-22/h7,9-11,14H,6H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255794
PNG
(1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-methylazeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H25ClN6O/c1-10-15(21)6-14(18(28-5)16(10)13-7-26(4)8-13)12(3)27-20-17(11(2)25-27)19(22)23-9-24-20/h6,9,12-13H,7-8H2,1-5H3,(H2,22,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255795
PNG
(1-{1-[5-Chloro-3-(1-ethylazetidin-3-yl)-2-methoxy-...)
Show SMILES CCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C21H27ClN6O/c1-6-27-8-14(9-27)17-11(2)16(22)7-15(19(17)29-5)13(4)28-21-18(12(3)26-28)20(23)24-10-25-21/h7,10,13-14H,6,8-9H2,1-5H3,(H2,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255799
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C21H26ClN7O2/c1-10-15(22)6-14(18(31-5)16(10)13-7-28(8-13)21(30)24-4)12(3)29-20-17(11(2)27-29)19(23)25-9-26-20/h6,9,12-13H,7-8H2,1-5H3,(H,24,30)(H2,23,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255807
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)NCCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O3/c1-12-17(25)10-16(14(3)32-23-20(13(2)31-32)22(26)29-11-30-23)21(35-4)19(12)15-5-6-27-18(9-15)24(34)28-7-8-33/h5-6,9-11,14,33H,7-8H2,1-4H3,(H,28,34)(H2,26,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289019
PNG
(US10092570, Example 20 | US9730939, Example 20)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCO)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-16(22)7-15(19(31-4)17(11)14-8-26-28(9-14)5-6-30)13(3)29-21-18(12(2)27-29)20(23)24-10-25-21/h7-10,13,30H,5-6H2,1-4H3,(H2,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289024
PNG
(US10092570, Example 25 | US9730939, Example 25)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN6O3/c1-13-17(26)10-16(14(2)32-9-8-19(33)21-23(27)29-12-30-24(21)32)22(35-5)20(13)15-6-7-18(28-11-15)25(34)31(3)4/h6-12,14H,1-5H3,(H2,27,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255817
PNG
(4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255822
PNG
(4-Amino-8-{1-[5-chloro-3-(5-fluoropyridin-3-yl)-2-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(F)c1)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C22H19ClFN5O2/c1-11-16(23)7-15(20(31-3)18(11)13-6-14(24)9-26-8-13)12(2)29-5-4-17(30)19-21(25)27-10-28-22(19)29/h4-10,12H,1-3H3,(H2,25,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255823
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255828
PNG
(6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255834
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H22ClN7O3S/c1-5-34-21-16(13(3)31-23-19(12(2)30-31)22(26)28-11-29-23)7-18(24)17(8-25)20(21)14-6-15(10-27-9-14)35(4,32)33/h6-7,9-11,13H,5H2,1-4H3,(H2,26,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%