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Patent code US9730939

Compile Data Set for Download or QSAR

Found 366 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255821
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H26ClN5O3/c1-14-19(27)12-18(15(2)32-10-9-20(33)22-24(28)29-13-30-25(22)32)23(35-5)21(14)16-7-6-8-17(11-16)26(34)31(3)4/h6-13,15H,1-5H3,(H2,28,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255830
PNG
(4-{3-[1-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)NCCO)C(C)n1ncc2c(N)ncnc12
Show InChI InChI=1S/C23H24ClN7O3/c1-12-17(24)9-15(13(2)31-22-16(10-30-31)21(25)28-11-29-22)20(34-3)19(12)14-4-5-26-18(8-14)23(33)27-6-7-32/h4-5,8-11,13,32H,6-7H2,1-3H3,(H,27,33)(H2,25,28,29)
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n/an/a 125n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255831
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(C#N)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28N8O3/c1-14-18(12-27)10-19(16(3)34-25-22(15(2)32-34)24(28)30-13-31-25)23(37-5)21(14)17-6-7-29-20(11-17)26(36)33(4)8-9-35/h6-7,10-11,13,16,35H,8-9H2,1-5H3,(H2,28,30,31)
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n/an/a 30n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255839
PNG
(5-(3-{1-[4-amino-3-(1H-pyrazol-4-yl)-1H-pyrazolo[3...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cn[nH]c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H28ClN9O2/c1-6-39-24-18(9-19(28)14(2)21(24)16-7-8-20(30-10-16)27(38)36(4)5)15(3)37-26-22(25(29)31-13-32-26)23(35-37)17-11-33-34-12-17/h7-13,15H,6H2,1-5H3,(H,33,34)(H2,29,31,32)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255840
PNG
(5-(3-{1-[4-amino-3-(1-methyl-1H-pyrazol-4-yl)-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cnn(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H30ClN9O2/c1-7-40-25-19(10-20(29)15(2)22(25)17-8-9-21(31-11-17)28(39)36(4)5)16(3)38-27-23(26(30)32-14-33-27)24(35-38)18-12-34-37(6)13-18/h8-14,16H,7H2,1-6H3,(H2,30,32,33)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255852
PNG
(5-{3-[1-(4-amino-3-pyridin-3-yl-1H-pyrazolo[3,4-d]...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cccnc2)c2c(N)ncnc12
Show InChI InChI=1S/C29H29ClN8O2/c1-6-40-26-20(12-21(30)16(2)23(26)18-9-10-22(33-14-18)29(39)37(4)5)17(3)38-28-24(27(31)34-15-35-28)25(36-38)19-8-7-11-32-13-19/h7-15,17H,6H2,1-5H3,(H2,31,34,35)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255855
PNG
(1-(1-{5-chloro-2-methoxy-4-methyl-3-[1-(tetrahydro...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1CCOCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31ClN6O2/c1-13-19(25)9-18(15(3)31-24-21(14(2)29-31)23(26)27-12-28-24)22(32-4)20(13)16-10-30(11-16)17-5-7-33-8-6-17/h9,12,15-17H,5-8,10-11H2,1-4H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255863
PNG
(1-{1-[5-Chloro-4-fluoro-2-methoxy-3-(1-oxetan-3-yl...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H22ClFN6O/c1-9-14-18(22)23-8-24-19(14)27(25-9)10(2)12-5-13(20)16(21)15(17(12)28-4)11-6-26(3)7-11/h5,8,10-11H,6-7H2,1-4H3,(H2,22,23,24)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261058
PNG
(5-{3-[1-(4-Amino-3-ethyl-1H-pyrazolo[3,4-d]pyrimid...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CC)c2c(N)ncnc12
Show InChI InChI=1S/C26H30ClN7O2/c1-7-19-22-24(28)30-13-31-25(22)34(32-19)15(4)17-11-18(27)14(3)21(23(17)36-8-2)16-9-10-20(29-12-16)26(35)33(5)6/h9-13,15H,7-8H2,1-6H3,(H2,28,30,31)
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n/an/a 125n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261069
PNG
(3-{1-[4-Amino-3-(1H-indazol-6-yl)-1H-pyrazolo[3,4-...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(-c3ccc4cn[nH]c4c3)c3c(N)ncnc23)c1OCC
Show InChI InChI=1S/C26H27ClN8O2/c1-5-29-26(36)20-13(3)18(27)10-17(23(20)37-6-2)14(4)35-25-21(24(28)30-12-31-25)22(34-35)15-7-8-16-11-32-33-19(16)9-15/h7-12,14H,5-6H2,1-4H3,(H,29,36)(H,32,33)(H2,28,30,31)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261078
PNG
(1-[1-(5-Chloro-2-ethoxy-4-methyl-3-{1-[(1-methyl-1...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H29ClN8O2/c1-6-36-22-18(15(4)34-24-21(14(3)31-34)23(27)28-12-29-24)7-19(26)13(2)20(22)17-10-33(11-17)25(35)16-8-30-32(5)9-16/h7-9,12,15,17H,6,10-11H2,1-5H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261082
PNG
((3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-11-16(22)7-15(19(30-4)17(11)14-8-28(9-14)6-5-23)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h7,10,13-14H,6,8-9H2,1-4H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261088
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(N)=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClN7O2/c1-10-15(22)5-14(19(31-4)17(10)13-6-28(7-13)8-16(23)30)12(3)29-21-18(11(2)27-29)20(24)25-9-26-21/h5,9,12-13H,6-8H2,1-4H3,(H2,23,30)(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261095
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H27ClN6O3/c1-10-16(23)6-15(12(3)29-21-18(11(2)27-29)20(24)25-9-26-21)19(32-5)17(10)14-7-28(8-14)22(31)13(4)30/h6,9,12-14,30H,7-8H2,1-5H3,(H2,24,25,26)/t12?,13-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261102
PNG
(US10092570, Example 125 | US9707233, 125 | US97309...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(-c2cnn(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN9O/c1-13-18(25)7-17(22(35-4)19(13)16-10-33(11-16)6-5-26)14(2)34-24-20(23(27)28-12-29-24)21(31-34)15-8-30-32(3)9-15/h7-9,12,14,16H,6,10-11H2,1-4H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261105
PNG
(5-{1-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O/c1-11(2)31-8-15(9-31)17-12(3)14(7-26)6-16(20(17)33-5)13(4)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h6,10-11,13,15,21H,8-9H2,1-5H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261106
PNG
(5-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(CC(F)(F)F)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H22F5N7O/c1-10-12(5-28)4-14(18(35-3)15(10)13-6-33(7-13)8-22(25,26)27)11(2)34-21-16(17(32-34)19(23)24)20(29)30-9-31-21/h4,9,11,13,19H,6-8H2,1-3H3,(H2,29,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261109
PNG
(US10092570, Example 132 | US9707233, 132 | US97309...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-15(9-31)17-12(2)14(6-26)5-16(20(17)34-4)13(3)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h5,10-11,13,15,21,33H,7-9H2,1-4H3,(H2,27,28,29)/t11-,13?/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261124
PNG
(1-(1-{5-Chloro-3-[1-(2,2- difluoroethyl)azetidin-3...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-4-32-19-13(11(3)31-21-16(10(2)29-31)20(26)27-9-28-21)5-14(22)18(25)17(19)12-6-30(7-12)8-15(23)24/h5,9,11-12,15H,4,6-8H2,1-3H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261120
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261130
PNG
(US10092570, Example 153 | US9707233, 153 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClF3N6O2/c1-5-35-19-13(6-14(24)17(25)15(19)12-7-32(8-12)9-23(3,4)34)11(2)33-22-16(18(31-33)20(26)27)21(28)29-10-30-22/h6,10-12,20,34H,5,7-9H2,1-4H3,(H2,28,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261140
PNG
(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O/c1-12-17(23)10-16(20(30-5)18(12)15-6-8-28(4)9-7-15)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h10-11,14-15H,6-9H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261142
PNG
(5-(3-{1-[4-Amino-3-(cyanomethyl)-1H-pyrazolo[3,4-d...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CC#N)c2c(N)ncnc12
Show InChI InChI=1S/C26H27ClN8O2/c1-6-37-23-17(15(3)35-25-22(19(33-35)9-10-28)24(29)31-13-32-25)11-18(27)14(2)21(23)16-7-8-20(30-12-16)26(36)34(4)5/h7-8,11-13,15H,6,9H2,1-5H3,(H2,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261145
PNG
(1-(1-(5-chloro-2-methoxy-4- methyl-3-(pyrimidin-5-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncnc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O/c1-10-15(21)5-14(18(29-4)16(10)13-6-23-8-24-7-13)12(3)28-20-17(11(2)27-28)19(22)25-9-26-20/h5-9,12H,1-4H3,(H2,22,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261146
PNG
(1-(1-(3-(2-aminopyrimidin-5-yl)-5- chloro-2-methox...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnc(N)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21ClN8O/c1-9-14(21)5-13(17(30-4)15(9)12-6-24-20(23)25-7-12)11(3)29-19-16(10(2)28-29)18(22)26-8-27-19/h5-8,11H,1-4H3,(H2,22,26,27)(H2,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261147
PNG
(5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H20ClN7O/c1-11-17(23)6-16(20(31-4)18(11)15-5-14(7-24)8-26-9-15)13(3)30-22-19(12(2)29-30)21(25)27-10-28-22/h5-6,8-10,13H,1-4H3,(H2,25,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261154
PNG
(1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CC(C1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H25ClN8O2/c1-13-20(27)6-19(15(3)35-25-22(14(2)33-35)24(29)31-12-32-25)23(37-4)21(13)17-5-18(9-30-8-17)26(36)34-10-16(7-28)11-34/h5-6,8-9,12,15-16H,10-11H2,1-4H3,(H2,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261159
PNG
(1-(1-{3-[1-(1-Acetylpiperidin-4-yl)-1H-pyrazol-4-y...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(CC1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H31ClN8O2/c1-14-21(27)10-20(16(3)35-26-23(15(2)32-35)25(28)29-13-30-26)24(37-5)22(14)18-11-31-34(12-18)19-6-8-33(9-7-19)17(4)36/h10-13,16,19H,6-9H2,1-5H3,(H2,28,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261168
PNG
(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(=N)C(F)F
Show InChI InChI=1S/C24H26ClF2N7O2/c1-11-15(25)8-14(12(2)33-23-18(19(28)21(26)27)22(29)31-10-32-23)20(36-5)17(11)13-6-7-16(30-9-13)24(35)34(3)4/h6-10,12,21,28H,1-5H3,(H3,29,31,32,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261174
PNG
(1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(1-methyl-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-6-30-19-15(7-16(22)11(2)17(19)14-8-26-28(5)9-14)13(4)29-21-18(12(3)27-29)20(23)24-10-25-21/h7-10,13H,6H2,1-5H3,(H2,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334051
PNG
(2-(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-5-33-20-15(13(4)31-22-19(12(3)29-31)21(25)26-10-27-22)6-16(23)11(2)18(20)14-7-28-30(8-14)9-17(24)32/h6-8,10,13H,5,9H2,1-4H3,(H2,24,32)(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261188
PNG
(3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C#N)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C18H21ClN6O/c1-5-26-16-12(6-14(19)9(2)13(16)7-20)11(4)25-18-15(10(3)21)17(22)23-8-24-18/h6,8,11,21H,5H2,1-4H3,(H3,22,23,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334069
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289228
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C1CCOCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H30ClN7O2/c1-4-35-23-18(15(3)33-25-21(14(2)31-33)24(28)29-13-30-25)9-20(26)19(10-27)22(23)16-11-32(12-16)17-5-7-34-8-6-17/h9,13,15-17H,4-8,11-12H2,1-3H3,(H2,28,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261216
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)C(N)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN8O2/c1-6-35-20-15(13(3)33-22-18(12(2)31-33)21(27)29-11-30-22)7-17(25)16(8-26)19(20)14-9-32(10-14)24(4,5)23(28)34/h7,11,13-14H,6,9-10H2,1-5H3,(H2,28,34)(H2,27,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261222
PNG
(US10092570, Example 245 | US9707233, 245 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C(C)(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H30ClN7O2/c1-7-35-21-16(14(3)33-23-19(13(2)31-33)22(28)29-12-30-23)8-18(26)17(9-27)20(21)15-10-32(11-15)24(34)25(4,5)6/h8,12,14-15H,7,10-11H2,1-6H3,(H2,28,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261225
PNG
(US10092570, Example 248 | US9707233, 248 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O3S/c1-5-32-19-14(12(3)29-21-17(11(2)27-29)20(24)25-10-26-21)6-16(22)15(7-23)18(19)13-8-28(9-13)33(4,30)31/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261234
PNG
(US10092570, Example 257 | US9707233, 257 | US97309...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)NC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-5-33-19-14(12(3)31-21-17(11(2)29-31)20(25)27-10-28-21)6-16(23)15(7-24)18(19)13-8-30(9-13)22(32)26-4/h6,10,12-13H,5,8-9H2,1-4H3,(H,26,32)(H2,25,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261251
PNG
(US10092570, Example 274 | US9707233, 274 | US97309...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-11-18-21(25)26-10-27-22(18)30(28-11)12(2)15-4-17(23)16(5-24)19(20(15)31-3)13-6-29(7-13)14-8-32-9-14/h4,10,12-14H,6-9H2,1-3H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261269
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)NC(C)(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN8O2/c1-12-18-21(27)28-11-29-22(18)33(31-12)13(2)15-7-17(25)16(8-26)19(20(15)35-6)14-9-32(10-14)23(34)30-24(3,4)5/h7,11,13-14H,9-10H2,1-6H3,(H,30,34)(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261245
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-17-20(24)25-10-26-21(17)29(27-11)12(2)14-6-16(22)15(7-23)18(19(14)31-3)13-8-28(9-13)4-5-30/h6,10,12-13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334149
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28Cl2N6O2/c1-11-16-20(25)26-10-27-21(16)30(28-11)12(2)14-6-15(23)18(24)17(19(14)32-5)13-7-29(8-13)9-22(3,4)31/h6,10,12-13,31H,7-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261292
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CCCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-4-30-19-14(9-16(22)15(10-23)18(19)28-7-5-6-8-28)13(3)29-21-17(12(2)27-29)20(24)25-11-26-21/h9,11,13H,4-8H2,1-3H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246894
PNG
(4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CNC(=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334198
PNG
(Diastereomers of 4-{3-[1-(4-amino-3-methyl-1H-pyra...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1COC(=O)N1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-30-19(28)25-12)9(3)27-18-13(8(2)26-27)17(22)23-7-24-18/h5,7,9,12H,4,6H2,1-3H3,(H,25,28)(H2,22,23,24)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255798
PNG
(1-(1-{5-Chloro-2-methoxy-3-[1-(2-methoxyethyl)azet...)
Show SMILES COCCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C22H29ClN6O2/c1-12-17(23)8-16(20(31-5)18(12)15-9-28(10-15)6-7-30-4)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h8,11,14-15H,6-7,9-10H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255828
PNG
(6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US9730939 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%