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Patent code US9732044

Compile Data Set for Download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Androgen Receptor


(Homo sapiens (Human))
BDBM334276
PNG
(2-Hydroxy-2,4- dimethyl-pentanoic acid (2-bromo-6-...)
Show SMILES COc1cc(NC(=O)C(C)(O)CC(C)C)cc(Br)n1
Show InChI InChI=1S/C13H19BrN2O3/c1-8(2)7-13(3,18)12(17)15-9-5-10(14)16-11(6-9)19-4/h5-6,8,18H,7H2,1-4H3,(H,15,16,17)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/a 20n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334278
PNG
(4-(2-Hydroxy-2- methyl- pentanoylamino)- pyridine-...)
Show SMILES CCCC(C)(O)C(=O)Nc1ccnc(c1)C(=O)OC
Show InChI InChI=1S/C13H18N2O4/c1-4-6-13(2,18)12(17)15-9-5-7-14-10(8-9)11(16)19-3/h5,7-8,18H,4,6H2,1-3H3,(H,14,15,17)
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US Patent
n/an/an/a 6.00E+3n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334275
PNG
(N-(2-Bromo- pyridin-4-yl)-2- hydroxy-2-phenyl- pro...)
Show SMILES CC(O)(C(=O)Nc1ccnc(Br)c1)c1ccccc1
Show InChI InChI=1S/C14H13BrN2O2/c1-14(19,10-5-3-2-4-6-10)13(18)17-11-7-8-16-12(15)9-11/h2-9,19H,1H3,(H,16,17,18)
PDB
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US Patent
n/an/an/a 100n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334271
PNG
(2-Hydroxy-2- methyl- pentanoic acid (2-bromo-pyrid...)
Show SMILES CCCC(C)(O)C(=O)Nc1ccnc(Br)c1
Show InChI InChI=1S/C11H15BrN2O2/c1-3-5-11(2,16)10(15)14-8-4-6-13-9(12)7-8/h4,6-7,16H,3,5H2,1-2H3,(H,13,14,15)
PDB
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US Patent
n/an/an/a 75n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334272
PNG
(2-Hydroxy-2- methyl-hexanoic acid (2-bromo- 6-meth...)
Show SMILES CCCCC(C)(O)C(=O)Nc1cc(Br)nc(OC)c1
Show InChI InChI=1S/C13H19BrN2O3/c1-4-5-6-13(2,18)12(17)15-9-7-10(14)16-11(8-9)19-3/h7-8,18H,4-6H2,1-3H3,(H,15,16,17)
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US Patent
n/an/an/a 30n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334273
PNG
(2-Butyl-2- hydroxy-hexanoic acid (2-bromo- pyridin...)
Show SMILES CCCCC(O)(CCCC)C(=O)Nc1ccnc(Br)c1
Show InChI InChI=1S/C15H23BrN2O2/c1-3-5-8-15(20,9-6-4-2)14(19)18-12-7-10-17-13(16)11-12/h7,10-11,20H,3-6,8-9H2,1-2H3,(H,17,18,19)
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US Patent
n/an/an/a 15n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334274
PNG
(N-(2-Bromo-pyridin- 4-yl)-2-hydroxy-4- (4-methoxy-...)
Show SMILES COc1ccc(CCC(C)(O)C(=O)Nc2ccnc(Br)c2)cc1
Show InChI InChI=1S/C17H19BrN2O3/c1-17(22,9-7-12-3-5-14(23-2)6-4-12)16(21)20-13-8-10-19-15(18)11-13/h3-6,8,10-11,22H,7,9H2,1-2H3,(H,19,20,21)
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PC cid
PC sid
UniChem
US Patent
n/an/an/a 300n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM334277
PNG
(N-(2-Bromo-pyridin- 4-yl)-2-hydroxy- 2-methyl-4-ph...)
Show SMILES CC(O)(CCc1ccccc1)C(=O)Nc1ccnc(Br)c1
Show InChI InChI=1S/C16H17BrN2O2/c1-16(21,9-7-12-5-3-2-4-6-12)15(20)19-13-8-10-18-14(17)11-13/h2-6,8,10-11,21H,7,9H2,1H3,(H,18,19,20)
PDB
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PC sid
UniChem
US Patent
n/an/an/a 100n/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides described herein exhibit androgen receptor (AR) inhibiting properties. This AR inhibiting activ...


US Patent US9732044 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%