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Patent code US9732085

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor XI


(Homo sapiens (Human))
BDBM335414
PNG
(4-(2-{(3S)-8-chloro-7-[5-chloro-2-(1H-tetrazol-1-y...)
Show SMILES OC(=O)c1cc(cs1)-c1cnc([nH]1)[C@@H]1CCc2c(Cl)c(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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US Patent
n/an/a 1.10n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335416
PNG
(5-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Show SMILES OC(=O)c1ccc(s1)-c1[nH]c(nc1F)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335412
PNG
(4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Show SMILES OC(=O)c1cc(cs1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335399
PNG
((3S)-3-[5-(6-amino-3-pyridinyl)-4-chloro-1H-imidaz...)
Show SMILES Nc1ccc(cn1)-c1[nH]c(nc1Cl)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335418
PNG
(4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Show SMILES OC(=O)c1scc(c1F)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335413
PNG
(5-(2-{(3S)-8-chloro-7-[5-chloro-2-(1H-tetrazol-1-y...)
Show SMILES OC(=O)c1ccc(s1)-c1cnc([nH]1)[C@@H]1CCc2c(Cl)c(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335419
PNG
(4-(5-{7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-ox...)
Show SMILES OC(=O)c1cc(cs1)-c1nc(F)c([nH]1)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335415
PNG
(4-(2-{(6S)-2-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Show SMILES OC(=O)c1cc(cs1)-c1cnc([nH]1)[C@@H]1CCc2nc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335393
PNG
(US9732085, 57 | methyl{4-[5-chloro-2-({4-[5-chloro...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(Cn2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)nc1Cl
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335393
PNG
(US9732085, 57 | methyl{4-[5-chloro-2-({4-[5-chloro...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(Cn2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)nc1Cl
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335408
PNG
(US9732085, 290 | methyl[4-(2-{(3S)-7-[5-chloro-2-(...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cc(nn1)C#N
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335400
PNG
((3S)-3-[5-(6-amino-2-chloro-3-pyridinyl)-1H-imidaz...)
Show SMILES Nc1ccc(-c2cnc([nH]2)[C@@H]2CCc3cc(cc(=O)n23)-c2cc(Cl)ccc2-n2cnnn2)c(Cl)n1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335420
PNG
(US9732085, Comp Ex 1)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@H](Cc1ccccc1)NC(=O)CCc1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335401
PNG
((3S)-3-[5-(6-amino-2-fluoro-3-pyridinyl)-1H-imidaz...)
Show SMILES Nc1ccc(-c2cnc([nH]2)[C@@H]2CCc3cc(cc(=O)n23)-c2cc(Cl)ccc2-n2cnnn2)c(F)n1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335396
PNG
(6-(2-{7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-ox...)
Show SMILES Clc1ccc(c(c1)-c1cc2CCC(c3nc(c[nH]3)-c3ccc4NC(=O)CCc4c3)n2c(=O)c1)-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335411
PNG
(5-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Show SMILES OC(=O)c1ccc(s1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335397
PNG
(US9732085, 129(2) | isopropyl[4-(2-{7-[5-chloro-2-...)
Show SMILES CC(C)OC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
PDB
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335403
PNG
(US9732085, 241 | methyl[4-(4-chloro-5-{7-[5-chloro...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1nc(Cl)c([nH]1)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335410
PNG
(US9732085, 310 | methyl[4-(2-{(3S)-7-[5-chloro-2-(...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cc(Cl)nn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335407
PNG
(US9732085, 278 | methyl(4-{2-[1-{4-[5-chloro-2-(1H...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C(Cc1cccnc1)n1ccc(cc1=O)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335405
PNG
(US9732085, 264 | methyl{4-[4-chloro-2-(1-{4-[5-chl...)
Show SMILES COCCC(c1nc(Cl)c([nH]1)-c1ccc(NC(=O)OC)cc1)n1ccc(cc1=O)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335391
PNG
(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C1CCc2nc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335391
PNG
(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C1CCc2nc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335394
PNG
(US9732085, 60 | methyl{4-[5-chloro-2-(1-{4-[5-chlo...)
Show SMILES CCC(c1nc(c(Cl)[nH]1)-c1ccc(NC(=O)OC)cc1)n1ccc(cc1=O)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 7.20n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335409
PNG
(US9732085, 309 | methyl[4-(2-{(3S)-7-[5-methyl-2-(...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(C)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335402
PNG
(US9732085, 230 | methyl[6-(4-chloro-2-{(3S)-7-[5-c...)
Show SMILES COC(=O)Nc1ccc(nc1)-c1[nH]c(nc1Cl)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335406
PNG
(US9732085, 270 | methyl[4-(2-{(3R)-7-[5-chloro-2-(...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CSc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 11n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335417
PNG
(4-[2-({4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-6-m...)
Show SMILES Cc1cc(cc(=O)n1Cc1ncc([nH]1)-c1csc(c1)C(O)=O)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 13n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335395
PNG
(US9732085, 61 | methyl{4-[2-(1-{4-[5-chloro-2-(1H-...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C(C)n1ccc(cc1=O)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 14n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335392
PNG
(US9732085, 45)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 15n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335392
PNG
(US9732085, 45)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 15n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335404
PNG
(US9732085, 245 | methyl[4-(5-{7-[5-chloro-2-(1H-te...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1nnc([nH]1)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 17n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335421
PNG
(US9732085, Comp Ex 2)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@H](C)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1
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n/an/a 40n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335398
PNG
(US9732085, 181 | methyl[5-(2-{7-[5-chloro-2-(1H-te...)
Show SMILES COC(=O)Nc1ccc(s1)-c1cnc([nH]1)C1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1
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n/an/a 47n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335422
PNG
(US9732085, Comp Ex 3)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(CNC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)nc1Cl
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n/an/a 130n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM335423
PNG
(US9732085, Comp. Ex 4)
Show SMILES COc1cc(Nc2ccc3CCCC(c4ccc(F)cc4)n3c2=O)ccc1-n1cnc(C)c1
Show InChI InChI=1S/C26H25FN4O2/c1-17-15-30(16-28-17)24-13-10-20(14-25(24)33-2)29-22-12-11-21-4-3-5-23(31(21)26(22)32)18-6-8-19(27)9-7-18/h6-16,23,29H,3-5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


US Patent US9732085 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%