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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| bace2 (Homo sapiens (Human)) | BDBM335430 ((3R,6S)-5-amino-3-(2-((3- bromo-1,7-naphthyridin-8...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335458 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335434 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335466 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335424 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335459 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335447 ((3R,6S)-5-amino-3-(2-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335454 ((3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335456 ((3R,6S)-5-amino-3-(5-((7- bromopyrido[3,2-d]pyrimi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335447 ((3R,6S)-5-amino-3-(2-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335474 ((3R,6S)-5-amino-3-(2-((7- chloro-1,5-naphthyridin-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335466 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335448 ((3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335467 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335454 ((3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335469 ((3R,6S)-5-amino-3-(2-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335444 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335424 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335458 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335457 (4-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335430 ((3R,6S)-5-amino-3-(2-((3- bromo-1,7-naphthyridin-8...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335431 (8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335469 ((3R,6S)-5-amino-3-(2-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335459 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335475 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335470 ((3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335456 ((3R,6S)-5-amino-3-(5-((7- bromopyrido[3,2-d]pyrimi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335462 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335476 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335457 (4-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335461 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335473 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335434 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335455 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335471 ((3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335468 ((3R,6S)-5-amino-3-(2-((3- chloro-1,7-naphthyridin-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335453 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335465 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335437 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335472 ((3R,6S)-3-(2-((1,5- naphthyridin-4-yl)amino)-5- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335461 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335431 (8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335479 ((3R,6S)-5-amino-3-(2-((7- bromopyrido[3,2-d]pyrimi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335438 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335438 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335465 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335476 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335462 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335453 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335474 ((3R,6S)-5-amino-3-(2-((7- chloro-1,5-naphthyridin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335473 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335427 (8-((6-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335437 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335448 ((3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335433 (8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335479 ((3R,6S)-5-amino-3-(2-((7- bromopyrido[3,2-d]pyrimi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335475 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335433 (8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335455 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335468 ((3R,6S)-5-amino-3-(2-((3- chloro-1,7-naphthyridin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335463 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335467 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335480 (4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335444 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 13.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335463 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335427 (8-((6-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335480 (4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335477 ((3R,6S)-5-amino-6- cycIopropyl-3-(2-fluoro-5-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335460 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335470 ((3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335477 ((3R,6S)-5-amino-6- cycIopropyl-3-(2-fluoro-5-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335478 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335478 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335472 ((3R,6S)-3-(2-((1,5- naphthyridin-4-yl)amino)-5- fl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335460 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335471 ((3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace2 (Homo sapiens (Human)) | BDBM335464 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335458 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 146 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335427 (8-((6-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromet...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 159 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| bace-1 (Homo sapiens (Human)) | BDBM335464 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 271 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335456 ((3R,6S)-5-amino-3-(5-((7- bromopyrido[3,2-d]pyrimi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 321 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335424 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromet...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 563 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335453 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 629 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335473 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335459 (8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 651 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335433 (8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335474 ((3R,6S)-5-amino-3-(2-((7- chloro-1,5-naphthyridin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335448 ((3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 857 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335437 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335455 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335461 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335457 (4-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335479 ((3R,6S)-5-amino-3-(2-((7- bromopyrido[3,2-d]pyrimi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335454 ((3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335438 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335475 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335430 ((3R,6S)-5-amino-3-(2-((3- bromo-1,7-naphthyridin-8...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335431 (8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335465 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335460 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335464 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335434 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335472 ((3R,6S)-3-(2-((1,5- naphthyridin-4-yl)amino)-5- fl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335471 ((3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335477 ((3R,6S)-5-amino-6- cycIopropyl-3-(2-fluoro-5-((7- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335478 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335447 ((3R,6S)-5-amino-3-(2-((3-(but- 2-yn-1-yloxy)-1,7-n...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335476 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335467 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335463 ((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335444 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335480 (4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335469 ((3R,6S)-5-amino-3-(2-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335466 ((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335468 ((3R,6S)-5-amino-3-(2-((3- chloro-1,7-naphthyridin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cathepsin D (Homo sapiens (Human)) | BDBM335470 ((3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As... | US Patent US9732088 (2017) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
