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Patent code US9737522

Compile Data Set for Download or QSAR
Found 17 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333427
PNG
(US9737522, Compound 1)
Show SMILES O[C@@H]1CC[C@H]([C@@H]1O)c1nnc2c(NCCc3ccc(F)c(F)c3)nccn12
Show InChI InChI=1S/C18H19F2N5O2/c19-12-3-1-10(9-13(12)20)5-6-21-16-18-24-23-17(25(18)8-7-22-16)11-2-4-14(26)15(11)27/h1,3,7-9,11,14-15,26-27H,2,4-6H2,(H,21,22)/t11-,14-,15+/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333437
PNG
(US9737522, Compound 11)
Show SMILES Cc1ccc(cc1)C1N(CCc2c[nH]c3cc(Cl)ccc23)C(=O)C(O)=C1C(=O)c1cccnc1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333440
PNG
(US9737522, Compound 13)
Show SMILES Cc1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1cccc(O)c1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333428
PNG
(US9737522, Compound 2)
Show SMILES O[C@@H]1CC[C@H]([C@@H]1O)c1nnc2c(NCCc3ccc(F)c(Cl)c3)nccn12
Show InChI InChI=1S/C18H19ClFN5O2/c19-12-9-10(1-3-13(12)20)5-6-21-16-18-24-23-17(25(18)8-7-22-16)11-2-4-14(26)15(11)27/h1,3,7-9,11,14-15,26-27H,2,4-6H2,(H,21,22)/t11-,14-,15+/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333430
PNG
(US9737522, Compound 4)
Show SMILES O[C@@H]1CC[C@H]([C@@H]1O)c1nnc2c(NCCc3ccc(Cl)c(F)c3)nccn12
Show InChI InChI=1S/C18H19ClFN5O2/c19-12-3-1-10(9-13(12)20)5-6-21-16-18-24-23-17(25(18)8-7-22-16)11-2-4-14(26)15(11)27/h1,3,7-9,11,14-15,26-27H,2,4-6H2,(H,21,22)/t11-,14-,15+/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333429
PNG
(US9737522, Compound 3)
Show SMILES O[C@@H]1CC[C@H]([C@@H]1O)c1nnc2c(N[C@H]3C[C@@H]3c3ccccc3)nccn12
Show InChI InChI=1S/C19H21N5O2/c25-15-7-6-12(16(15)26)18-22-23-19-17(20-8-9-24(18)19)21-14-10-13(14)11-4-2-1-3-5-11/h1-5,8-9,12-16,25-26H,6-7,10H2,(H,20,21)/t12-,13-,14+,15-,16+/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333441
PNG
(US9737522, Compound 14)
Show SMILES Cc1ccc(cc1)C1N(CCc2cccc3ccccc23)C(=O)C(O)=C1C(=O)c1ccncc1
Show InChI InChI=1S/C29H24N2O3/c1-19-9-11-22(12-10-19)26-25(27(32)23-13-16-30-17-14-23)28(33)29(34)31(26)18-15-21-7-4-6-20-5-2-3-8-24(20)21/h2-14,16-17,26,33H,15,18H2,1H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333432
PNG
(US9737522, Compound 6)
Show SMILES CCc1ccc(cc1)C1N(CCc2c(C)[nH]c3ccccc23)C(=O)C(O)=C1C(C)=O
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333450
PNG
(US9737522, Compound 15)
Show SMILES OC1=C(C(N(CCc2c[nH]c3ccccc23)C1=O)c1cccs1)C(=O)c1cccnc1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333436
PNG
(US9737522, Compound 10)
Show SMILES Cc1ccc(cc1)C1N(CCc2c[nH]c3cc(F)ccc23)C(=O)C(O)=C1C(=O)c1cccnc1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333434
PNG
(US9737522, Compound 8)
Show SMILES CC(=O)C1=C(O)C(=O)N(CCc2c[nH]c3ccccc23)C1c1ccc(C)cc1O
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333431
PNG
(US9737522, Compound 5)
Show SMILES CCc1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(C)=O
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333433
PNG
(US9737522, Compound 7)
Show SMILES COc1cc(C)ccc1C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(C)=O
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333435
PNG
(US9737522, Compound 9)
Show SMILES CC(=O)C1=C(O)C(=O)N(CCc2c[nH]c3ccccc23)C1c1ccc(C)cc1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333439
PNG
(US9737522, Compound 12)
Show SMILES Cc1ccc(cc1)C1N(CCc2c[nH]c3ccccc23)C(=O)C(O)=C1C(=O)c1ccccc1Cl
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333451
PNG
(US9737522, Compound 16)
Show SMILES Cc1ccc(cc1)C1N(CCc2c[nH]cn2)C(=O)C(O)=C1C(=O)c1ccncc1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 1 (NR2C)


(Rattus norvegicus (Rat))
BDBM333452
PNG
(US9737522, Compound 17)
Show SMILES Cc1ccc(cc1)C1N(CCc2ccncc2)C(=O)C(O)=C1C(=O)c1ccncc1
Show InChI InChI=1S/C24H21N3O3/c1-16-2-4-18(5-3-16)21-20(22(28)19-8-13-26-14-9-19)23(29)24(30)27(21)15-10-17-6-11-25-12-7-17/h2-9,11-14,21,29H,10,15H2,1H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
Two-electrode voltage-clamp recordings were made from Xenopus laevis oocytes expressing recombinant rat GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, Glu...


US Patent US9737522 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%