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Patent code US9737544

Compile Data Set for Download or QSAR
Found 120 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335684
PNG
(US9737544, Compound 16)
Show SMILES COc1cccc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12H,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335692
PNG
(US9737544, Compound 25)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-18(12-26-27)17-6-16-9-22(25-13-23(16)24-11-17)21(4-5-28)15-7-19(29-2)10-20(8-15)30-3/h6-14,21,28H,4-5H2,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335692
PNG
(US9737544, Compound 25)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-18(12-26-27)17-6-16-9-22(25-13-23(16)24-11-17)21(4-5-28)15-7-19(29-2)10-20(8-15)30-3/h6-14,21,28H,4-5H2,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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n/an/a 251n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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n/an/a 501n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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n/an/a 501n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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n/an/a 251n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a 398n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a 63.1n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335694
PNG
(US9737544, Compound 26)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-16(10-23-24)15-6-14-8-18(22-11-19(14)21-9-15)20(25)13-4-3-5-17(7-13)26-2/h3-12H,1-2H3
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n/an/a 2.51E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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n/an/a 50.1n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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n/an/a 631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335674
PNG
(US9737544, Compound 3)
Show SMILES COc1cc(OC)cc(c1)C(C)(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N5O3/c1-21(27,14-7-15(28-3)9-16(8-14)29-4)19-6-5-17-20(25-19)24-18(11-22-17)13-10-23-26(2)12-13/h5-12,27H,1-4H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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n/an/a 501n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335676
PNG
(US9737544, Compound 5)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\C=Cc2ncc(nc2N1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O4/c1-26-13-15(11-24-26)19-12-23-18-4-5-20(27(6-7-28)22(18)25-19)21(29)14-8-16(30-2)10-17(9-14)31-3/h4-5,8-13,28-29H,6-7H2,1-3H3/b21-20+
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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n/an/a 1.26E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335684
PNG
(US9737544, Compound 16)
Show SMILES COc1cccc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335687
PNG
(US9737544, Compound 20)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O4/c1-26-16-9-14(10-17(12-16)27-2)21(25)19-4-3-18-20(23-19)11-15(13-22-18)24-5-7-28-8-6-24/h3-4,9-13H,5-8H2,1-2H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335687
PNG
(US9737544, Compound 20)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O4/c1-26-16-9-14(10-17(12-16)27-2)21(25)19-4-3-18-20(23-19)11-15(13-22-18)24-5-7-28-8-6-24/h3-4,9-13H,5-8H2,1-2H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335688
PNG
(US9737544, Compound 21)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-33-25(29)15-21(17-11-19(30-2)14-20(12-17)31-3)22-5-6-23-24(27-22)13-18(16-26-23)28-7-9-32-10-8-28/h5-6,11-14,16,21H,4,7-10,15H2,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335691
PNG
(US9737544, Compound 24)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)11-22(16-7-20(31-3)10-21(8-16)32-4)23-9-17-6-18(12-26-24(17)14-27-23)19-13-28-29(2)15-19/h6-10,12-15,22H,5,11H2,1-4H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335693
PNG
(US9737544, Compound 12)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\CC=c2ncc(cc2=[N]1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N4O4/c1-26-14-17(13-25-26)16-10-22-20(24-12-16)4-5-21(27(22)6-7-28)23(29)15-8-18(30-2)11-19(9-15)31-3/h4,8-14,28-29H,5-7H2,1-3H3/b23-21+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335694
PNG
(US9737544, Compound 26)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-16(10-23-24)15-6-14-8-18(22-11-19(14)21-9-15)20(25)13-4-3-5-17(7-13)26-2/h3-12H,1-2H3
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n/an/a 5.01E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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n/an/a 15.8n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335674
PNG
(US9737544, Compound 3)
Show SMILES COc1cc(OC)cc(c1)C(C)(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N5O3/c1-21(27,14-7-15(28-3)9-16(8-14)29-4)19-6-5-17-20(25-19)24-18(11-22-17)13-10-23-26(2)12-13/h5-12,27H,1-4H3
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n/an/a 6.31E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 31.6n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 251n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335684
PNG
(US9737544, Compound 16)
Show SMILES COc1cccc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335689
PNG
(US9737544, Compound 23)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-16(10-24-25)15-4-13-7-19(23-11-20(13)22-9-15)21(26)14-5-17(27-2)8-18(6-14)28-3/h4-12H,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335689
PNG
(US9737544, Compound 23)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-16(10-24-25)15-4-13-7-19(23-11-20(13)22-9-15)21(26)14-5-17(27-2)8-18(6-14)28-3/h4-12H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335691
PNG
(US9737544, Compound 24)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)11-22(16-7-20(31-3)10-21(8-16)32-4)23-9-17-6-18(12-26-24(17)14-27-23)19-13-28-29(2)15-19/h6-10,12-15,22H,5,11H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335693
PNG
(US9737544, Compound 12)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\CC=c2ncc(cc2=[N]1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N4O4/c1-26-14-17(13-25-26)16-10-22-20(24-12-16)4-5-21(27(22)6-7-28)23(29)15-8-18(30-2)11-19(9-15)31-3/h4,8-14,28-29H,5-7H2,1-3H3/b23-21+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335694
PNG
(US9737544, Compound 26)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-16(10-23-24)15-6-14-8-18(22-11-19(14)21-9-15)20(25)13-4-3-5-17(7-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335694
PNG
(US9737544, Compound 26)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-16(10-23-24)15-6-14-8-18(22-11-19(14)21-9-15)20(25)13-4-3-5-17(7-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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n/an/a 79.4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 501n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 126n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 251n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335688
PNG
(US9737544, Compound 21)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-33-25(29)15-21(17-11-19(30-2)14-20(12-17)31-3)22-5-6-23-24(27-22)13-18(16-26-23)28-7-9-32-10-8-28/h5-6,11-14,16,21H,4,7-10,15H2,1-3H3
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n/an/a 5.01E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335689
PNG
(US9737544, Compound 23)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-16(10-24-25)15-4-13-7-19(23-11-20(13)22-9-15)21(26)14-5-17(27-2)8-18(6-14)28-3/h4-12H,1-3H3
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n/an/a 1.26E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335692
PNG
(US9737544, Compound 25)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-18(12-26-27)17-6-16-9-22(25-13-23(16)24-11-17)21(4-5-28)15-7-19(29-2)10-20(8-15)30-3/h6-14,21,28H,4-5H2,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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n/an/a 631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335674
PNG
(US9737544, Compound 3)
Show SMILES COc1cc(OC)cc(c1)C(C)(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N5O3/c1-21(27,14-7-15(28-3)9-16(8-14)29-4)19-6-5-17-20(25-19)24-18(11-22-17)13-10-23-26(2)12-13/h5-12,27H,1-4H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335676
PNG
(US9737544, Compound 5)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\C=Cc2ncc(nc2N1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O4/c1-26-13-15(11-24-26)19-12-23-18-4-5-20(27(6-7-28)22(18)25-19)21(29)14-8-16(30-2)10-17(9-14)31-3/h4-5,8-13,28-29H,6-7H2,1-3H3/b21-20+
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 126n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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n/an/a 79.4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 63.1n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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n/an/a 5.01E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335687
PNG
(US9737544, Compound 20)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O4/c1-26-16-9-14(10-17(12-16)27-2)21(25)19-4-3-18-20(23-19)11-15(13-22-18)24-5-7-28-8-6-24/h3-4,9-13H,5-8H2,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335688
PNG
(US9737544, Compound 21)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-33-25(29)15-21(17-11-19(30-2)14-20(12-17)31-3)22-5-6-23-24(27-22)13-18(16-26-23)28-7-9-32-10-8-28/h5-6,11-14,16,21H,4,7-10,15H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335692
PNG
(US9737544, Compound 25)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-18(12-26-27)17-6-16-9-22(25-13-23(16)24-11-17)21(4-5-28)15-7-19(29-2)10-20(8-15)30-3/h6-14,21,28H,4-5H2,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335693
PNG
(US9737544, Compound 12)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\CC=c2ncc(cc2=[N]1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N4O4/c1-26-14-17(13-25-26)16-10-22-20(24-12-16)4-5-21(27(22)6-7-28)23(29)15-8-18(30-2)11-19(9-15)31-3/h4,8-14,28-29H,5-7H2,1-3H3/b23-21+
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n/an/a 1.26E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335693
PNG
(US9737544, Compound 12)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\CC=c2ncc(cc2=[N]1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N4O4/c1-26-14-17(13-25-26)16-10-22-20(24-12-16)4-5-21(27(22)6-7-28)23(29)15-8-18(30-2)11-19(9-15)31-3/h4,8-14,28-29H,5-7H2,1-3H3/b23-21+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335674
PNG
(US9737544, Compound 3)
Show SMILES COc1cc(OC)cc(c1)C(C)(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N5O3/c1-21(27,14-7-15(28-3)9-16(8-14)29-4)19-6-5-17-20(25-19)24-18(11-22-17)13-10-23-26(2)12-13/h5-12,27H,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335676
PNG
(US9737544, Compound 5)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\C=Cc2ncc(nc2N1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O4/c1-26-13-15(11-24-26)19-12-23-18-4-5-20(27(6-7-28)22(18)25-19)21(29)14-8-16(30-2)10-17(9-14)31-3/h4-5,8-13,28-29H,6-7H2,1-3H3/b21-20+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335676
PNG
(US9737544, Compound 5)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\C=Cc2ncc(nc2N1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O4/c1-26-13-15(11-24-26)19-12-23-18-4-5-20(27(6-7-28)22(18)25-19)21(29)14-8-16(30-2)10-17(9-14)31-3/h4-5,8-13,28-29H,6-7H2,1-3H3/b21-20+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335676
PNG
(US9737544, Compound 5)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\C=Cc2ncc(nc2N1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O4/c1-26-13-15(11-24-26)19-12-23-18-4-5-20(27(6-7-28)22(18)25-19)21(29)14-8-16(30-2)10-17(9-14)31-3/h4-5,8-13,28-29H,6-7H2,1-3H3/b21-20+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335684
PNG
(US9737544, Compound 16)
Show SMILES COc1cccc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335687
PNG
(US9737544, Compound 20)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O4/c1-26-16-9-14(10-17(12-16)27-2)21(25)19-4-3-18-20(23-19)11-15(13-22-18)24-5-7-28-8-6-24/h3-4,9-13H,5-8H2,1-2H3
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n/an/a 2.51E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335688
PNG
(US9737544, Compound 21)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-33-25(29)15-21(17-11-19(30-2)14-20(12-17)31-3)22-5-6-23-24(27-22)13-18(16-26-23)28-7-9-32-10-8-28/h5-6,11-14,16,21H,4,7-10,15H2,1-3H3
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n/an/a 3.16E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335688
PNG
(US9737544, Compound 21)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-33-25(29)15-21(17-11-19(30-2)14-20(12-17)31-3)22-5-6-23-24(27-22)13-18(16-26-23)28-7-9-32-10-8-28/h5-6,11-14,16,21H,4,7-10,15H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335689
PNG
(US9737544, Compound 23)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-16(10-24-25)15-4-13-7-19(23-11-20(13)22-9-15)21(26)14-5-17(27-2)8-18(6-14)28-3/h4-12H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335689
PNG
(US9737544, Compound 23)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-16(10-24-25)15-4-13-7-19(23-11-20(13)22-9-15)21(26)14-5-17(27-2)8-18(6-14)28-3/h4-12H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335691
PNG
(US9737544, Compound 24)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)11-22(16-7-20(31-3)10-21(8-16)32-4)23-9-17-6-18(12-26-24(17)14-27-23)19-13-28-29(2)15-19/h6-10,12-15,22H,5,11H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335691
PNG
(US9737544, Compound 24)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)11-22(16-7-20(31-3)10-21(8-16)32-4)23-9-17-6-18(12-26-24(17)14-27-23)19-13-28-29(2)15-19/h6-10,12-15,22H,5,11H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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n/an/a 1.26E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335674
PNG
(US9737544, Compound 3)
Show SMILES COc1cc(OC)cc(c1)C(C)(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N5O3/c1-21(27,14-7-15(28-3)9-16(8-14)29-4)19-6-5-17-20(25-19)24-18(11-22-17)13-10-23-26(2)12-13/h5-12,27H,1-4H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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n/an/a 316n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a 501n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335684
PNG
(US9737544, Compound 16)
Show SMILES COc1cccc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12H,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 100n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335687
PNG
(US9737544, Compound 20)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O4/c1-26-16-9-14(10-17(12-16)27-2)21(25)19-4-3-18-20(23-19)11-15(13-22-18)24-5-7-28-8-6-24/h3-4,9-13H,5-8H2,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335691
PNG
(US9737544, Compound 24)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)11-22(16-7-20(31-3)10-21(8-16)32-4)23-9-17-6-18(12-26-24(17)14-27-23)19-13-28-29(2)15-19/h6-10,12-15,22H,5,11H2,1-4H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335692
PNG
(US9737544, Compound 25)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-18(12-26-27)17-6-16-9-22(25-13-23(16)24-11-17)21(4-5-28)15-7-19(29-2)10-20(8-15)30-3/h6-14,21,28H,4-5H2,1-3H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335693
PNG
(US9737544, Compound 12)
Show SMILES COc1cc(OC)cc(c1)C(\O)=C1\CC=c2ncc(cc2=[N]1CCO)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N4O4/c1-26-14-17(13-25-26)16-10-22-20(24-12-16)4-5-21(27(22)6-7-28)23(29)15-8-18(30-2)11-19(9-15)31-3/h4,8-14,28-29H,5-7H2,1-3H3/b23-21+
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335694
PNG
(US9737544, Compound 26)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-16(10-23-24)15-6-14-8-18(22-11-19(14)21-9-15)20(25)13-4-3-5-17(7-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%