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Patent code US9744172

Compile Data Set for Download or QSAR

Found 287 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336234
PNG
(US9744172, Compound UNC00000392A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1CO
Show InChI InChI=1S/C20H26N6O/c1-22-20-23-10-17-18(16-5-3-2-4-14(16)12-27)25-26(19(17)24-20)11-13-6-8-15(21)9-7-13/h2-5,10,13,15,27H,6-9,11-12,21H2,1H3,(H,22,23,24)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336236
PNG
(US9744172, Compound UNC00000481A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)C(=O)OC
Show InChI InChI=1S/C21H26N6O2/c1-23-21-24-11-17-18(14-5-7-15(8-6-14)20(28)29-2)26-27(19(17)25-21)12-13-3-9-16(22)10-4-13/h5-8,11,13,16H,3-4,9-10,12,22H2,1-2H3,(H,23,24,25)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336251
PNG
(US9744172, Compound UNC00000480A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1cnc[nH]1
Show InChI InChI=1S/C16H22N8/c1-18-16-20-6-12-14(13-7-19-9-21-13)23-24(15(12)22-16)8-10-2-4-11(17)5-3-10/h6-7,9-11H,2-5,8,17H2,1H3,(H,19,21)(H,18,20,22)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336254
PNG
(US9744172, Compound UNC00000411A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1cnc(N)nc1
Show InChI InChI=1S/C17H23N9/c1-20-17-23-8-13-14(11-6-21-16(19)22-7-11)25-26(15(13)24-17)9-10-2-4-12(18)5-3-10/h6-8,10,12H,2-5,9,18H2,1H3,(H2,19,21,22)(H,20,23,24)/t10?,12-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384599
PNG
(CHEMBL2036790 | US9744172, Compound UNC00000479A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(F)nc1
Show InChI InChI=1S/C18H22FN7/c1-21-18-23-9-14-16(12-4-7-15(19)22-8-12)25-26(17(14)24-18)10-11-2-5-13(20)6-3-11/h4,7-9,11,13H,2-3,5-6,10,20H2,1H3,(H,21,23,24)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336277
PNG
(US9744172, Compound UNC599A)
Show SMILES O[C@H]1CC[C@@H](Cn2nc(-c3ccc(nc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C30H38N8O/c39-25-11-8-23(9-12-25)21-38-29-26(20-34-30(35-29)32-14-4-7-22-5-2-1-3-6-22)28(36-38)24-10-13-27(33-19-24)37-17-15-31-16-18-37/h1-3,5-6,10,13,19-20,23,25,31,39H,4,7-9,11-12,14-18,21H2,(H,32,34,35)/t23-,25+
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336283
PNG
(US9744172, Compound UNC1057A)
Show SMILES O[C@H]1CCC(CC1)n1nc(-c2ccc(cc2)N2CCOCC2)c2cnc(NCCC(F)(F)F)nc12
Show InChI InChI=1S/C24H29F3N6O2/c25-24(26,27)9-10-28-23-29-15-20-21(16-1-3-17(4-2-16)32-11-13-35-14-12-32)31-33(22(20)30-23)18-5-7-19(34)8-6-18/h1-4,15,18-19,34H,5-14H2,(H,28,29,30)/t18?,19-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336286
PNG
(US9744172, Compound UNC783A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@@H](CC3)NS(C)(=O)=O)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H31FN6O2S/c1-3-4-13-25-23-26-14-20-21(17-7-9-18(24)10-8-17)28-30(22(20)27-23)15-16-5-11-19(12-6-16)29-33(2,31)32/h7-10,14,16,19,29H,3-6,11-13,15H2,1-2H3,(H,25,26,27)/t16?,19-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336290
PNG
(US9744172, Compound UNC00000544A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C19H24N6/c1-21-19-22-11-16-17(14-5-3-2-4-6-14)24-25(18(16)23-19)12-13-7-9-15(20)10-8-13/h2-6,11,13,15H,7-10,12,20H2,1H3,(H,21,22,23)/t13?,15-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336300
PNG
(US9744172, Compound UNC00000516A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@@H](CC3)N(C)C)c2n1)-c1ccccc1
Show InChI InChI=1S/C21H28N6/c1-22-21-23-13-18-19(16-7-5-4-6-8-16)25-27(20(18)24-21)14-15-9-11-17(12-10-15)26(2)3/h4-8,13,15,17H,9-12,14H2,1-3H3,(H,22,23,24)/t15?,17-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336303
PNG
(US9744172, Compound UNC00000547A)
Show SMILES CNc1ncc2c(nn(CCCCCN)c2n1)-c1ccccc1
Show InChI InChI=1S/C17H22N6/c1-19-17-20-12-14-15(13-8-4-2-5-9-13)22-23(16(14)21-17)11-7-3-6-10-18/h2,4-5,8-9,12H,3,6-7,10-11,18H2,1H3,(H,19,20,21)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336316
PNG
(US9744172, Compound UNC00000345A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCN4CCOCC4)nc23)CC1
Show InChI InChI=1S/C24H33N7O/c25-20-8-6-18(7-9-20)17-31-23-21(22(29-31)19-4-2-1-3-5-19)16-27-24(28-23)26-10-11-30-12-14-32-15-13-30/h1-5,16,18,20H,6-15,17,25H2,(H,26,27,28)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336318
PNG
(US9744172, Compound UNC00000261A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@H](O)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5O/c1-20-19-21-11-16-17(14-5-3-2-4-6-14)23-24(18(16)22-19)12-13-7-9-15(25)10-8-13/h2-6,11,13,15,25H,7-10,12H2,1H3,(H,20,21,22)/t13?,15-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336324
PNG
(US9744172, Compound UNC00000464A)
Show SMILES CCCCCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C25H36N6/c1-2-3-4-5-9-16-27-25-28-17-22-23(20-10-7-6-8-11-20)30-31(24(22)29-25)18-19-12-14-21(26)15-13-19/h6-8,10-11,17,19,21H,2-5,9,12-16,18,26H2,1H3,(H,27,28,29)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336325
PNG
(US9744172, Compound UNC00000467A)
Show SMILES COCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C22H30N6O/c1-29-13-5-12-24-22-25-14-19-20(17-6-3-2-4-7-17)27-28(21(19)26-22)15-16-8-10-18(23)11-9-16/h2-4,6-7,14,16,18H,5,8-13,15,23H2,1H3,(H,24,25,26)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384609
PNG
(CHEMBL2036802 | US9744172, Compound UNC00000546A)
Show SMILES COc1ccc(CNc2ncc3c(nn(CC4CCC(N)CC4)c3n2)-c2ccccc2)cc1
Show InChI InChI=1S/C26H30N6O/c1-33-22-13-9-18(10-14-22)15-28-26-29-16-23-24(20-5-3-2-4-6-20)31-32(25(23)30-26)17-19-7-11-21(27)12-8-19/h2-6,9-10,13-14,16,19,21H,7-8,11-12,15,17,27H2,1H3,(H,28,29,30)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336334
PNG
(US9744172, Compound UNC00000554A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4ccc(cc4)-c4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H32N6/c32-27-17-13-23(14-18-27)21-37-30-28(29(36-37)26-9-5-2-6-10-26)20-34-31(35-30)33-19-22-11-15-25(16-12-22)24-7-3-1-4-8-24/h1-12,15-16,20,23,27H,13-14,17-19,21,32H2,(H,33,34,35)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336357
PNG
(US9744172, Compound UNC707A)
Show SMILES CCCNc1ncc2c(nn(CC3CCN(CC3)C(=O)OC(C)(C)C)c2n1)-c1ccccc1OC
Show InChI InChI=1S/C26H36N6O3/c1-6-13-27-24-28-16-20-22(19-9-7-8-10-21(19)34-5)30-32(23(20)29-24)17-18-11-14-31(15-12-18)25(33)35-26(2,3)4/h7-10,16,18H,6,11-15,17H2,1-5H3,(H,27,28,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336376
PNG
(US9744172, Compound UNC1029A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C27H31FN6O3S/c1-2-3-16-29-27-30-17-24-25(32-34(26(24)31-27)21-10-12-22(35)13-11-21)18-4-14-23(15-5-18)38(36,37)33-20-8-6-19(28)7-9-20/h4-9,14-15,17,21-22,33,35H,2-3,10-13,16H2,1H3,(H,29,30,31)/t21?,22-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336380
PNG
(US9744172, Compound UNC1035A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C26H36N6O3S/c1-2-3-16-27-26-28-17-23-24(30-32(25(23)29-26)20-10-12-21(33)13-11-20)18-8-14-22(15-9-18)36(34,35)31-19-6-4-5-7-19/h8-9,14-15,17,19-21,31,33H,2-7,10-13,16H2,1H3,(H,27,28,29)/t20?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336392
PNG
(US9744172, Compound UNC904A)
Show SMILES CCCCNc1ncc2c(nn(C3CCCCC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C22H30N6O2S/c1-3-4-14-24-22-25-15-19-20(16-10-12-18(13-11-16)31(29,30)23-2)27-28(21(19)26-22)17-8-6-5-7-9-17/h10-13,15,17,23H,3-9,14H2,1-2H3,(H,24,25,26)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336398
PNG
(US9744172, Compound UNC910A)
Show SMILES CCCCNc1ncc2c(nn(CCCN3CCOCC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C23H33N7O3S/c1-3-4-10-25-23-26-17-20-21(18-6-8-19(9-7-18)34(31,32)24-2)28-30(22(20)27-23)12-5-11-29-13-15-33-16-14-29/h6-9,17,24H,3-5,10-16H2,1-2H3,(H,25,26,27)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336399
PNG
(US9744172, Compound UNC911A)
Show SMILES CCCCNc1ncc2c(nn(CCC3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C24H34N6O3S/c1-3-4-14-26-24-27-16-21-22(18-7-11-20(12-8-18)34(32,33)25-2)29-30(23(21)28-24)15-13-17-5-9-19(31)10-6-17/h7-8,11-12,16-17,19,25,31H,3-6,9-10,13-15H2,1-2H3,(H,26,27,28)/t17?,19-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336406
PNG
(US9744172, Compound UNC990A)
Show SMILES CCCCNc1ncc2c(nn(CCCO)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C19H26N6O3S/c1-3-4-10-21-19-22-13-16-17(24-25(11-5-12-26)18(16)23-19)14-6-8-15(9-7-14)29(27,28)20-2/h6-9,13,20,26H,3-5,10-12H2,1-2H3,(H,21,22,23)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336425
PNG
(US9744172, Compound UNC1172A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H34N6O3/c1-2-3-12-27-26-28-17-22-23(30-32(24(22)29-26)20-8-10-21(33)11-9-20)18-4-6-19(7-5-18)25(34)31-13-15-35-16-14-31/h4-7,17,20-21,33H,2-3,8-16H2,1H3,(H,27,28,29)/t20?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336428
PNG
(US9744172, Compound UNC1182A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCOCC1=O
Show InChI InChI=1S/C26H35N7O2/c1-2-3-12-28-26-29-15-22-24(19-6-10-21(11-7-19)32-13-14-35-17-23(32)34)31-33(25(22)30-26)16-18-4-8-20(27)9-5-18/h6-7,10-11,15,18,20H,2-5,8-9,12-14,16-17,27H2,1H3,(H,28,29,30)/t18?,20-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336429
PNG
(US9744172, Compound UNC1183A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C26H34N6O2/c1-2-3-14-27-26-28-17-22-23(30-32(24(22)29-26)20-10-12-21(33)13-11-20)18-6-8-19(9-7-18)25(34)31-15-4-5-16-31/h6-9,17,20-21,33H,2-5,10-16H2,1H3,(H,27,28,29)/t20?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336453
PNG
(US9744172, Compound UNC1223A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NC2CCCC2)cc1
Show InChI InChI=1S/C27H37N7O2/c1-2-3-16-28-26-29-17-23-24(33-34(25(23)32-26)21-12-14-22(35)15-13-21)18-8-10-20(11-9-18)31-27(36)30-19-6-4-5-7-19/h8-11,17,19,21-22,35H,2-7,12-16H2,1H3,(H,28,29,32)(H2,30,31,36)/t21?,22-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336454
PNG
(US9744172, Compound UNC1142A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C27H39N7O3S/c1-3-5-14-28-27-29-19-24-25(31-34(26(24)30-27)21-8-10-22(35)11-9-21)20-6-12-23(13-7-20)38(36,37)33-17-15-32(4-2)16-18-33/h6-7,12-13,19,21-22,35H,3-5,8-11,14-18H2,1-2H3,(H,28,29,30)/t21?,22-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336462
PNG
(US9744172, Compound UNC1150A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(N)CC1
Show InChI InChI=1S/C26H37N7O3S/c1-2-3-14-28-26-29-17-23-24(31-33(25(23)30-26)20-6-8-21(34)9-7-20)18-4-10-22(11-5-18)37(35,36)32-15-12-19(27)13-16-32/h4-5,10-11,17,19-21,34H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336474
PNG
(US9744172, Compound UNC1236A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(O)=O
Show InChI InChI=1S/C24H32N6O5S/c1-2-3-13-25-24-26-15-20-22(29-30(23(20)28-24)17-6-8-18(31)9-7-17)16-4-10-19(11-5-16)36(34,35)27-14-12-21(32)33/h4-5,10-11,15,17-18,27,31H,2-3,6-9,12-14H2,1H3,(H,32,33)(H,25,26,28)/t17?,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336491
PNG
(US9744172, Compound UNC1319A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C36H40FN7O4S/c1-3-4-21-38-36-40-23-32-33(42-44(34(32)41-36)29-15-17-30(45)18-16-29)25-9-19-31(20-10-25)49(47,48)43(2)28-13-7-26(8-14-28)35(46)39-22-24-5-11-27(37)12-6-24/h5-14,19-20,23,29-30,45H,3-4,15-18,21-22H2,1-2H3,(H,39,46)(H,38,40,41)/t29?,30-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336495
PNG
(US9744172, Compound UNC1323A)
Show SMILES CCCCCNC(=O)c1ccc(cc1)N(C)S(=O)(=O)c1ccc(cc1)-c1nn(C2CC[C@H](O)CC2)c2nc(NCCCC)ncc12
Show InChI InChI=1S/C34H45N7O4S/c1-4-6-8-22-35-33(43)25-9-13-26(14-10-25)40(3)46(44,45)29-19-11-24(12-20-29)31-30-23-37-34(36-21-7-5-2)38-32(30)41(39-31)27-15-17-28(42)18-16-27/h9-14,19-20,23,27-28,42H,4-8,15-18,21-22H2,1-3H3,(H,35,43)(H,36,37,38)/t27?,28-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336514
PNG
(US9744172, Compound UNC1287A)
Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCNCC2)c(F)c1
Show InChI InChI=1S/C25H34FN7O/c1-2-3-10-28-25-29-16-20-23(31-33(24(20)30-25)18-5-7-19(34)8-6-18)17-4-9-22(21(26)15-17)32-13-11-27-12-14-32/h4,9,15-16,18-19,27,34H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t18-,19-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336229
PNG
(US9744172, Compound UNC00000354A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H23FN6/c1-22-19-23-10-16-17(13-4-6-14(20)7-5-13)25-26(18(16)24-19)11-12-2-8-15(21)9-3-12/h4-7,10,12,15H,2-3,8-9,11,21H2,1H3,(H,22,23,24)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336237
PNG
(US9744172, Compound UNC00000482A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H23N7/c1-23-20-24-11-17-18(15-6-2-13(10-21)3-7-15)26-27(19(17)25-20)12-14-4-8-16(22)9-5-14/h2-3,6-7,11,14,16H,4-5,8-9,12,22H2,1H3,(H,23,24,25)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336239
PNG
(US9744172, Compound UNC00000487A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C26H30N6O/c1-28-26-29-15-23-24(31-32(25(23)30-26)16-18-7-11-21(27)12-8-18)20-9-13-22(14-10-20)33-17-19-5-3-2-4-6-19/h2-6,9-10,13-15,18,21H,7-8,11-12,16-17,27H2,1H3,(H,28,29,30)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336240
PNG
(US9744172, Compound UNC00000394A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C20H24N6O2/c1-22-20-23-9-15-18(13-4-7-16-17(8-13)28-11-27-16)25-26(19(15)24-20)10-12-2-5-14(21)6-3-12/h4,7-9,12,14H,2-3,5-6,10-11,21H2,1H3,(H,22,23,24)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336245
PNG
(US9744172, Compound UNC00000483A)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)-c1nn(CC2CCC(N)CC2)c2nc(NC)ncc12
Show InChI InChI=1S/C27H32N6O/c1-3-34-23-14-10-20(11-15-23)19-6-8-21(9-7-19)25-24-16-30-27(29-2)31-26(24)33(32-25)17-18-4-12-22(28)13-5-18/h6-11,14-16,18,22H,3-5,12-13,17,28H2,1-2H3,(H,29,30,31)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336264
PNG
(US9744172, Compound UNC00000548A)
Show SMILES CNc1ncc2c(Cc3ccccc3)nn(CC3CCC(N)CC3)c2n1
Show InChI InChI=1S/C20H26N6/c1-22-20-23-12-17-18(11-14-5-3-2-4-6-14)25-26(19(17)24-20)13-15-7-9-16(21)10-8-15/h2-6,12,15-16H,7-11,13,21H2,1H3,(H,22,23,24)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384584
PNG
(CHEMBL2036807 | US9744172, Compound UNC607A)
Show SMILES N[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H40N8/c32-26-12-8-24(9-13-26)22-39-30-28(21-35-31(36-30)34-16-4-7-23-5-2-1-3-6-23)29(37-39)25-10-14-27(15-11-25)38-19-17-33-18-20-38/h1-3,5-6,10-11,14-15,21,24,26,33H,4,7-9,12-13,16-20,22,32H2,(H,34,35,36)/t24-,26-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336273
PNG
(US9744172, Compound UNC603A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-8-21(9-7-20)32-15-13-27-14-16-32)31-33(25(23)30-26)18-19-4-10-22(34)11-5-19/h6-9,17,19,22,27,34H,2-5,10-16,18H2,1H3,(H,28,29,30)/t19-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336275
PNG
(US9744172, Compound UNC606A)
Show SMILES CCCCNc1ncc2c(nn(CC3CCNCC3)c2n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C24H35N9/c1-2-3-8-27-24-29-16-20-22(19-4-5-21(28-15-19)32-13-11-26-12-14-32)31-33(23(20)30-24)17-18-6-9-25-10-7-18/h4-5,15-16,18,25-26H,2-3,6-14,17H2,1H3,(H,27,29,30)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336284
PNG
(US9744172, Compound UNC1067A)
Show SMILES O[C@H]1CCC(CC1)n1nc(-c2ccc(cc2)N2CCOCC2)c2cnc(NCC(F)(F)F)nc12
Show InChI InChI=1S/C23H27F3N6O2/c24-23(25,26)14-28-22-27-13-19-20(15-1-3-16(4-2-15)31-9-11-34-12-10-31)30-32(21(19)29-22)17-5-7-18(33)8-6-17/h1-4,13,17-18,33H,5-12,14H2,(H,27,28,29)/t17?,18-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336292
PNG
(US9744172, Compound UNC00000263A)
Show SMILES CNc1ncc2c(nn(CC3CCCNC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C18H22N6/c1-19-18-21-11-15-16(14-7-3-2-4-8-14)23-24(17(15)22-18)12-13-6-5-9-20-10-13/h2-4,7-8,11,13,20H,5-6,9-10,12H2,1H3,(H,19,21,22)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336296
PNG
(US9744172, Compound UNC00000415A)
Show SMILES CNc1ncc2c(nn(Cc3cccc(N)c3)c2n1)-c1ccccc1
Show InChI InChI=1S/C19H18N6/c1-21-19-22-11-16-17(14-7-3-2-4-8-14)24-25(18(16)23-19)12-13-6-5-9-15(20)10-13/h2-11H,12,20H2,1H3,(H,21,22,23)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336299
PNG
(US9744172, Compound UNC00000515A)
Show SMILES CN[C@H]1CCC(Cn2nc(-c3ccccc3)c3cnc(NC)nc23)CC1
Show InChI InChI=1S/C20H26N6/c1-21-16-10-8-14(9-11-16)13-26-19-17(12-23-20(22-2)24-19)18(25-26)15-6-4-3-5-7-15/h3-7,12,14,16,21H,8-11,13H2,1-2H3,(H,22,23,24)/t14?,16-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336304
PNG
(US9744172, Compound UNC00000585A)
Show SMILES CNc1ncc2c(nn(CCCCN)c2n1)-c1ccccc1
Show InChI InChI=1S/C16H20N6/c1-18-16-19-11-13-14(12-7-3-2-4-8-12)21-22(15(13)20-16)10-6-5-9-17/h2-4,7-8,11H,5-6,9-10,17H2,1H3,(H,18,19,20)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336348
PNG
(US9744172, Compound UNC00000268A | US9744172, Comp...)
Show SMILES CNc1ncc2c(nn(CC3CCCN3)c2n1)C(C)=C
Show InChI InChI=1S/C14H20N6/c1-9(2)12-11-7-17-14(15-3)18-13(11)20(19-12)8-10-5-4-6-16-10/h7,10,16H,1,4-6,8H2,2-3H3,(H,15,17,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336354
PNG
(US9744172, Compound UNC705A)
Show SMILES CCCNc1ncc2c(nn(C3CCCCC3)c2n1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H25N5O2/c1-2-12-22-21-23-13-17-18(14-8-10-15(11-9-14)20(27)28)25-26(19(17)24-21)16-6-4-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,27,28)(H,22,23,24)
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%