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Patent code US9744172

Compile Data Set for Download or QSAR

Found 287 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384594
PNG
(CHEMBL2036630 | US9744172, Compound UNC00000356A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C20H26N6O/c1-22-20-23-11-17-18(14-5-9-16(27-2)10-6-14)25-26(19(17)24-20)12-13-3-7-15(21)8-4-13/h5-6,9-11,13,15H,3-4,7-8,12,21H2,1-2H3,(H,22,23,24)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336236
PNG
(US9744172, Compound UNC00000481A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)C(=O)OC
Show InChI InChI=1S/C21H26N6O2/c1-23-21-24-11-17-18(14-5-7-15(8-6-14)20(28)29-2)26-27(19(17)25-21)12-13-3-9-16(22)10-4-13/h5-8,11,13,16H,3-4,9-10,12,22H2,1-2H3,(H,23,24,25)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336242
PNG
(US9744172, Compound UNC00000484A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H25N7/c1-23-21-25-11-17-19(15-5-4-14-8-9-24-18(14)10-15)27-28(20(17)26-21)12-13-2-6-16(22)7-3-13/h4-5,8-11,13,16,24H,2-3,6-7,12,22H2,1H3,(H,23,25,26)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336254
PNG
(US9744172, Compound UNC00000411A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1cnc(N)nc1
Show InChI InChI=1S/C17H23N9/c1-20-17-23-8-13-14(11-6-21-16(19)22-7-11)25-26(15(13)24-17)9-10-2-4-12(18)5-3-10/h6-8,10,12H,2-5,9,18H2,1H3,(H2,19,21,22)(H,20,23,24)/t10?,12-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384580
PNG
(CHEMBL2036789 | US9744172, Compound UNC00000490A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1cccnc1
Show InChI InChI=1S/C18H23N7/c1-20-18-22-10-15-16(13-3-2-8-21-9-13)24-25(17(15)23-18)11-12-4-6-14(19)7-5-12/h2-3,8-10,12,14H,4-7,11,19H2,1H3,(H,20,22,23)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336262
PNG
(US9744172, Compound UNC583A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H38N8/c1-2-3-12-29-26-30-17-23-24(20-6-10-22(11-7-20)33-15-13-28-14-16-33)32-34(25(23)31-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21,28H,2-5,8-9,12-16,18,27H2,1H3,(H,29,30,31)/t19?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336269
PNG
(US9744172, Compound UNC595A)
Show SMILES CCCCNc1ncc2c(nn(C[C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C25H36N8O/c1-2-3-10-27-25-29-16-21-23(19-6-9-22(28-15-19)32-13-11-26-12-14-32)31-33(24(21)30-25)17-18-4-7-20(34)8-5-18/h6,9,15-16,18,20,26,34H,2-5,7-8,10-14,17H2,1H3,(H,27,29,30)/t18-,20+
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336275
PNG
(US9744172, Compound UNC606A)
Show SMILES CCCCNc1ncc2c(nn(CC3CCNCC3)c2n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C24H35N9/c1-2-3-8-27-24-29-16-20-22(19-4-5-21(28-15-19)32-13-11-26-12-14-32)31-33(23(20)30-24)17-18-6-9-25-10-7-18/h4-5,15-16,18,25-26H,2-3,6-14,17H2,1H3,(H,27,29,30)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336281
PNG
(US9744172, Compound UNC605A)
Show SMILES O[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H39N7O/c39-27-14-8-24(9-15-27)22-38-30-28(21-34-31(35-30)33-16-4-7-23-5-2-1-3-6-23)29(36-38)25-10-12-26(13-11-25)37-19-17-32-18-20-37/h1-3,5-6,10-13,21,24,27,32,39H,4,7-9,14-20,22H2,(H,33,34,35)/t24-,27-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336286
PNG
(US9744172, Compound UNC783A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@@H](CC3)NS(C)(=O)=O)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H31FN6O2S/c1-3-4-13-25-23-26-14-20-21(17-7-9-18(24)10-8-17)28-30(22(20)27-23)15-16-5-11-19(12-6-16)29-33(2,31)32/h7-10,14,16,19,29H,3-6,11-13,15H2,1-2H3,(H,25,26,27)/t16?,19-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336293
PNG
(US9744172, Compound UNC00000264A)
Show SMILES CNc1ncc2c(nn(CC3CCCN3)c2n1)-c1ccccc1
Show InChI InChI=1S/C17H20N6/c1-18-17-20-10-14-15(12-6-3-2-4-7-12)22-23(16(14)21-17)11-13-8-5-9-19-13/h2-4,6-7,10,13,19H,5,8-9,11H2,1H3,(H,18,20,21)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336298
PNG
(US9744172, Compound UNC00000514A)
Show SMILES CN[C@H]1CCC(Cn2nc(-c3ccccc3)c3cnc(NC)nc23)CC1
Show InChI InChI=1S/C20H26N6/c1-21-16-10-8-14(9-11-16)13-26-19-17(12-23-20(22-2)24-19)18(25-26)15-6-4-3-5-7-15/h3-7,12,14,16,21H,8-11,13H2,1-2H3,(H,22,23,24)/t14?,16-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336299
PNG
(US9744172, Compound UNC00000515A)
Show SMILES CN[C@H]1CCC(Cn2nc(-c3ccccc3)c3cnc(NC)nc23)CC1
Show InChI InChI=1S/C20H26N6/c1-21-16-10-8-14(9-11-16)13-26-19-17(12-23-20(22-2)24-19)18(25-26)15-6-4-3-5-7-15/h3-7,12,14,16,21H,8-11,13H2,1-2H3,(H,22,23,24)/t14?,16-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336300
PNG
(US9744172, Compound UNC00000516A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@@H](CC3)N(C)C)c2n1)-c1ccccc1
Show InChI InChI=1S/C21H28N6/c1-22-21-23-13-18-19(16-7-5-4-6-8-16)25-27(20(18)24-21)14-15-9-11-17(12-10-15)26(2)3/h4-8,13,15,17H,9-12,14H2,1-3H3,(H,22,23,24)/t15?,17-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384601
PNG
(CHEMBL2036793 | US9744172, Compound UNC00000349A)
Show SMILES CN(C)c1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C20H26N6/c1-25(2)20-22-12-17-18(15-6-4-3-5-7-15)24-26(19(17)23-20)13-14-8-10-16(21)11-9-14/h3-7,12,14,16H,8-11,13,21H2,1-2H3
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336309
PNG
(US9744172, Compound UNC00000351A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(nc23)N2CCCC2)CC1
Show InChI InChI=1S/C22H28N6/c23-18-10-8-16(9-11-18)15-28-21-19(20(26-28)17-6-2-1-3-7-17)14-24-22(25-21)27-12-4-5-13-27/h1-3,6-7,14,16,18H,4-5,8-13,15,23H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384607
PNG
(CHEMBL2036800 | US9744172, Compound UNC00000470A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCCN4CCOCC4)nc23)CC1
Show InChI InChI=1S/C25H35N7O/c26-21-9-7-19(8-10-21)18-32-24-22(23(30-32)20-5-2-1-3-6-20)17-28-25(29-24)27-11-4-12-31-13-15-33-16-14-31/h1-3,5-6,17,19,21H,4,7-16,18,26H2,(H,27,28,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336343
PNG
(US9744172, Compound UNC00000266A)
Show SMILES CNc1ncc2c(nn(CC3CC[C@H](O)CC3)c2n1)C(C)=C
Show InChI InChI=1S/C16H23N5O/c1-10(2)14-13-8-18-16(17-3)19-15(13)21(20-14)9-11-4-6-12(22)7-5-11/h8,11-12,22H,1,4-7,9H2,2-3H3,(H,17,18,19)/t11?,12-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336357
PNG
(US9744172, Compound UNC707A)
Show SMILES CCCNc1ncc2c(nn(CC3CCN(CC3)C(=O)OC(C)(C)C)c2n1)-c1ccccc1OC
Show InChI InChI=1S/C26H36N6O3/c1-6-13-27-24-28-16-20-22(19-9-7-8-10-21(19)34-5)30-32(23(20)29-24)17-18-11-14-31(15-12-18)25(33)35-26(2,3)4/h7-10,16,18H,6,11-15,17H2,1-5H3,(H,27,28,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336367
PNG
(US9744172, Compound UNC974A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCC
Show InChI InChI=1S/C25H36N6O3S/c1-3-5-15-26-25-27-17-22-23(30-31(24(22)29-25)19-9-11-20(32)12-10-19)18-7-13-21(14-8-18)35(33,34)28-16-6-4-2/h7-8,13-14,17,19-20,28,32H,3-6,9-12,15-16H2,1-2H3,(H,26,27,29)/t19?,20-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336371
PNG
(US9744172, Compound UNC980A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C28H34N6O3S/c1-3-4-17-29-28-30-18-25-26(32-34(27(25)31-28)22-11-13-23(35)14-12-22)20-7-9-21(10-8-20)33-38(36,37)24-15-5-19(2)6-16-24/h5-10,15-16,18,22-23,33,35H,3-4,11-14,17H2,1-2H3,(H,29,30,31)/t22?,23-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336376
PNG
(US9744172, Compound UNC1029A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C27H31FN6O3S/c1-2-3-16-29-27-30-17-24-25(32-34(26(24)31-27)21-10-12-22(35)13-11-21)18-4-14-23(15-5-18)38(36,37)33-20-8-6-19(28)7-9-20/h4-9,14-15,17,21-22,33,35H,2-3,10-13,16H2,1H3,(H,29,30,31)/t21?,22-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336378
PNG
(US9744172, Compound UNC1032A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-2-3-16-30-28-31-18-25-26(34-35(27(25)33-28)22-10-12-23(36)13-11-22)20-6-14-24(15-7-20)39(37,38)32-17-19-4-8-21(29)9-5-19/h4-9,14-15,18,22-23,32,36H,2-3,10-13,16-17H2,1H3,(H,30,31,33)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336379
PNG
(US9744172, Compound UNC1033A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-2-3-16-30-28-31-18-25-26(34-35(27(25)33-28)22-10-12-23(36)13-11-22)20-6-14-24(15-7-20)39(37,38)32-17-19-4-8-21(29)9-5-19/h4-9,14-15,18,22-23,32,36H,2-3,10-13,16-17H2,1H3,(H,30,31,33)/t22?,23-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336399
PNG
(US9744172, Compound UNC911A)
Show SMILES CCCCNc1ncc2c(nn(CCC3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C24H34N6O3S/c1-3-4-14-26-24-27-16-21-22(18-7-11-20(12-8-18)34(32,33)25-2)29-30(23(21)28-24)15-13-17-5-9-19(31)10-6-17/h7-8,11-12,16-17,19,25,31H,3-6,9-10,13-15H2,1-2H3,(H,26,27,28)/t17?,19-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336401
PNG
(US9744172, Compound UNC913A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C23H33N7O2S/c1-3-4-13-26-23-27-14-20-21(17-7-11-19(12-8-17)33(31,32)25-2)29-30(22(20)28-23)15-16-5-9-18(24)10-6-16/h7-8,11-12,14,16,18,25H,3-6,9-10,13,15,24H2,1-2H3,(H,26,27,28)/t16-,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336421
PNG
(US9744172, Compound UNC1170A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H37N7O2/c1-2-3-12-29-27-30-17-23-24(32-34(25(23)31-27)18-19-4-10-22(28)11-5-19)20-6-8-21(9-7-20)26(35)33-13-15-36-16-14-33/h6-9,17,19,22H,2-5,10-16,18,28H2,1H3,(H,29,30,31)/t19?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336430
PNG
(US9744172, Compound UNC1095A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C28H41N7O4S/c1-2-3-13-29-28-30-20-25-26(33-35(27(25)32-28)22-7-9-23(36)10-8-22)21-5-11-24(12-6-21)40(37,38)31-14-4-15-34-16-18-39-19-17-34/h5-6,11-12,20,22-23,31,36H,2-4,7-10,13-19H2,1H3,(H,29,30,32)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336437
PNG
(US9744172, Compound UNC1174A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C32H47N7O5S/c1-5-6-17-33-30-34-21-27-28(37-39(29(27)36-30)24-9-11-25(40)12-10-24)23-7-13-26(14-8-23)45(42,43)35-20-22-15-18-38(19-16-22)31(41)44-32(2,3)4/h7-8,13-14,21-22,24-25,35,40H,5-6,9-12,15-20H2,1-4H3,(H,33,34,36)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336447
PNG
(US9744172, Compound UNC1189A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)N2CCCC2)cc1
Show InChI InChI=1S/C26H35N7O2/c1-2-3-14-27-25-28-17-22-23(31-33(24(22)30-25)20-10-12-21(34)13-11-20)18-6-8-19(9-7-18)29-26(35)32-15-4-5-16-32/h6-9,17,20-21,34H,2-5,10-16H2,1H3,(H,29,35)(H,27,28,30)/t20?,21-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336454
PNG
(US9744172, Compound UNC1142A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C27H39N7O3S/c1-3-5-14-28-27-29-19-24-25(31-34(26(24)30-27)21-8-10-22(35)11-9-21)20-6-12-23(13-7-20)38(36,37)33-17-15-32(4-2)16-18-33/h6-7,12-13,19,21-22,35H,3-5,8-11,14-18H2,1-2H3,(H,28,29,30)/t21?,22-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336457
PNG
(US9744172, Compound UNC1145A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H43N7O4S/c1-2-3-14-31-30-32-21-27-28(34-37(29(27)33-30)24-6-8-25(38)9-7-24)22-4-10-26(11-5-22)42(39,40)36-15-12-23(13-16-36)35-17-19-41-20-18-35/h4-5,10-11,21,23-25,38H,2-3,6-9,12-20H2,1H3,(H,31,32,33)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336459
PNG
(US9744172, Compound UNC1147A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C23H32N6O3S/c1-4-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)28(2)3)27-29(22(20)26-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,30H,4-5,8-11,14H2,1-3H3,(H,24,25,26)/t17?,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336470
PNG
(US9744172, Compound UNC1269A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCCCC1
Show InChI InChI=1S/C30H43N7O4S/c1-2-3-18-31-30-32-20-26-28(36-37(29(26)35-30)23-11-13-24(38)14-12-23)21-9-15-25(16-10-21)42(40,41)33-19-17-27(39)34-22-7-5-4-6-8-22/h9-10,15-16,20,22-24,33,38H,2-8,11-14,17-19H2,1H3,(H,34,39)(H,31,32,35)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336473
PNG
(US9744172, Compound UNC1235A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C21H28N6O/c1-2-3-12-23-21-24-13-18-19(14-4-6-15(22)7-5-14)26-27(20(18)25-21)16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12,22H2,1H3,(H,23,24,25)/t16?,17-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336483
PNG
(US9744172, Compound UNC1311A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)C2CC2)cc1
Show InChI InChI=1S/C25H32N6O2/c1-2-3-14-26-25-27-15-21-22(16-6-8-18(9-7-16)28-24(33)17-4-5-17)30-31(23(21)29-25)19-10-12-20(32)13-11-19/h6-9,15,17,19-20,32H,2-5,10-14H2,1H3,(H,28,33)(H,26,27,29)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336485
PNG
(US9744172, Compound UNC1313A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCOCC
Show InChI InChI=1S/C33H43N7O5S/c1-4-6-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(3)25-11-7-24(8-12-25)32(42)34-20-21-45-5-2/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336486
PNG
(US9744172, Compound UNC1314A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCOCC
Show InChI InChI=1S/C33H43N7O5S/c1-4-6-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(3)25-11-7-24(8-12-25)32(42)34-20-21-45-5-2/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336498
PNG
(US9744172, Compound UNC1326A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(C)=O
Show InChI InChI=1S/C28H35N7O3/c1-4-5-14-29-27-30-15-22-24(34-35(26(22)33-27)20-10-12-21(37)13-11-20)18-6-8-19(9-7-18)25-23(17(3)36)16(2)31-28(38)32-25/h6-9,15,20-21,25,37H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t20?,21-,25?
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384598
PNG
(CHEMBL2036788 | US9744172, Compound UNC00000393A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H28N6/c1-27-25-28-15-22-23(20-11-9-19(10-12-20)18-5-3-2-4-6-18)30-31(24(22)29-25)16-17-7-13-21(26)14-8-17/h2-6,9-12,15,17,21H,7-8,13-14,16,26H2,1H3,(H,27,28,29)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336246
PNG
(US9744172, Compound UNC00000395A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccco1
Show InChI InChI=1S/C17H22N6O/c1-19-17-20-9-13-15(14-3-2-8-24-14)22-23(16(13)21-17)10-11-4-6-12(18)7-5-11/h2-3,8-9,11-12H,4-7,10,18H2,1H3,(H,19,20,21)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336248
PNG
(US9744172, Compound UNC00000398A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1cccs1
Show InChI InChI=1S/C17H22N6S/c1-19-17-20-9-13-15(14-3-2-8-24-14)22-23(16(13)21-17)10-11-4-6-12(18)7-5-11/h2-3,8-9,11-12H,4-7,10,18H2,1H3,(H,19,20,21)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384600
PNG
(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C23H32N8/c1-25-23-27-14-20-21(17-4-8-19(9-5-17)30-12-10-26-11-13-30)29-31(22(20)28-23)15-16-2-6-18(24)7-3-16/h4-5,8-9,14,16,18,26H,2-3,6-7,10-13,15,24H2,1H3,(H,25,27,28)
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336272
PNG
(US9744172, Compound UNC602A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H28FN5O/c1-2-3-12-24-22-25-13-19-20(16-6-8-17(23)9-7-16)27-28(21(19)26-22)14-15-4-10-18(29)11-5-15/h6-9,13,15,18,29H,2-5,10-12,14H2,1H3,(H,24,25,26)/t15-,18-
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336277
PNG
(US9744172, Compound UNC599A)
Show SMILES O[C@H]1CC[C@@H](Cn2nc(-c3ccc(nc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C30H38N8O/c39-25-11-8-23(9-12-25)21-38-29-26(20-34-30(35-29)32-14-4-7-22-5-2-1-3-6-22)28(36-38)24-10-13-27(33-19-24)37-17-15-31-16-18-37/h1-3,5-6,10,13,19-20,23,25,31,39H,4,7-9,11-12,14-18,21H2,(H,32,34,35)/t23-,25+
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n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336285
PNG
(US9744172, Compound UNC782A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@@H](CC3)NC(C)=O)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H31FN6O/c1-3-4-13-26-24-27-14-21-22(18-7-9-19(25)10-8-18)30-31(23(21)29-24)15-17-5-11-20(12-6-17)28-16(2)32/h7-10,14,17,20H,3-6,11-13,15H2,1-2H3,(H,28,32)(H,26,27,29)/t17?,20-
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336292
PNG
(US9744172, Compound UNC00000263A)
Show SMILES CNc1ncc2c(nn(CC3CCCNC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C18H22N6/c1-19-18-21-11-15-16(14-7-3-2-4-8-14)23-24(17(15)22-18)12-13-6-5-9-20-10-13/h2-4,7-8,11,13,20H,5-6,9-10,12H2,1H3,(H,19,21,22)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336302
PNG
(US9744172, Compound UNC00000556A)
Show SMILES CNc1ncc2c(nn(CCOCCN)c2n1)-c1ccccc1
Show InChI InChI=1S/C16H20N6O/c1-18-16-19-11-13-14(12-5-3-2-4-6-12)21-22(15(13)20-16)8-10-23-9-7-17/h2-6,11H,7-10,17H2,1H3,(H,18,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336304
PNG
(US9744172, Compound UNC00000585A)
Show SMILES CNc1ncc2c(nn(CCCCN)c2n1)-c1ccccc1
Show InChI InChI=1S/C16H20N6/c1-18-16-19-11-13-14(12-7-3-2-4-8-12)21-22(15(13)20-16)10-6-5-9-17/h2-4,7-8,11H,5-6,9-10,17H2,1H3,(H,18,19,20)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336335
PNG
(US9744172, Compound UNC00000550A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4ccc(cc4)C(F)(F)F)nc23)CC1
Show InChI InChI=1S/C26H27F3N6/c27-26(28,29)20-10-6-17(7-11-20)14-31-25-32-15-22-23(19-4-2-1-3-5-19)34-35(24(22)33-25)16-18-8-12-21(30)13-9-18/h1-7,10-11,15,18,21H,8-9,12-14,16,30H2,(H,31,32,33)
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n/an/a 550n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 287 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%