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Patent code US9744172

Compile Data Set for Download or QSAR

Found 287 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336466
PNG
(US9744172, Compound UNC1265A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C30H44N8O4S/c1-3-4-16-31-30-32-20-26-28(36-38(29(26)35-30)23-7-9-24(39)10-8-23)21-5-11-25(12-6-21)43(41,42)33-17-13-27(40)34-22-14-18-37(2)19-15-22/h5-6,11-12,20,22-24,33,39H,3-4,7-10,13-19H2,1-2H3,(H,34,40)(H,31,32,35)/t23?,24-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336486
PNG
(US9744172, Compound UNC1314A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCOCC
Show InChI InChI=1S/C33H43N7O5S/c1-4-6-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(3)25-11-7-24(8-12-25)32(42)34-20-21-45-5-2/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336487
PNG
(US9744172, Compound UNC1315A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCCOC
Show InChI InChI=1S/C33H43N7O5S/c1-4-5-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(2)25-11-7-24(8-12-25)32(42)34-20-6-21-45-3/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336506
PNG
(US9744172, Compound UNC1350A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C33H40FN7O3/c1-4-5-18-35-33-36-19-27-29(40-41(30(27)39-33)25-14-16-26(42)17-15-25)21-6-8-22(9-7-21)31(43)38-28(20(2)3)32(44)37-24-12-10-23(34)11-13-24/h6-13,19-20,25-26,28,42H,4-5,14-18H2,1-3H3,(H,37,44)(H,38,43)(H,35,36,39)/t25?,26-,28-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336509
PNG
(US9744172, Compound UNC1227A)
Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCO
Show InChI InChI=1S/C23H32N6O4S/c1-2-3-12-24-23-25-15-20-21(16-4-10-19(11-5-16)34(32,33)26-13-14-30)28-29(22(20)27-23)17-6-8-18(31)9-7-17/h4-5,10-11,15,17-18,26,30-31H,2-3,6-9,12-14H2,1H3,(H,24,25,27)/t17-,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336263
PNG
(US9744172, Compound UNC582A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-10-22(11-7-20)32-13-15-34-16-14-32)31-33(25(23)30-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21H,2-5,8-9,12-16,18,27H2,1H3,(H,28,29,30)/t19?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336372
PNG
(US9744172, Compound UNC983A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC
Show InChI InChI=1S/C23H32N6O3S/c1-3-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)26-4-2)28-29(22(20)27-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,26,30H,3-5,8-11,14H2,1-2H3,(H,24,25,27)/t17?,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336383
PNG
(US9744172, Compound UNC1059A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC
Show InChI InChI=1S/C24H34N6O3S/c1-3-5-15-25-24-26-16-21-22(17-6-12-20(13-7-17)34(32,33)27-14-4-2)29-30(23(21)28-24)18-8-10-19(31)11-9-18/h6-7,12-13,16,18-19,27,31H,3-5,8-11,14-15H2,1-2H3,(H,25,26,28)/t18?,19-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336394
PNG
(US9744172, Compound UNC906A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C22H30N6O3S/c1-3-4-13-24-22-25-14-19-20(15-5-11-18(12-6-15)32(30,31)23-2)27-28(21(19)26-22)16-7-9-17(29)10-8-16/h5-6,11-12,14,16-17,23,29H,3-4,7-10,13H2,1-2H3,(H,24,25,26)/t16?,17-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336407
PNG
(US9744172, Compound UNC1084A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C26H36FN7O/c1-2-3-10-29-26-30-16-21-24(19-6-9-23(22(27)15-19)33-11-13-35-14-12-33)32-34(25(21)31-26)17-18-4-7-20(28)8-5-18/h6,9,15-16,18,20H,2-5,7-8,10-14,17,28H2,1H3,(H,29,30,31)/t18-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336410
PNG
(US9744172, Compound UNC1168A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(Br)cc1
Show InChI InChI=1S/C22H29BrN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15-,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336417
PNG
(US9744172, Compound UNC1062A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C25H34N6O4S/c1-2-3-12-26-25-27-17-22-23(29-31(24(22)28-25)19-6-8-20(32)9-7-19)18-4-10-21(11-5-18)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17,19-20,32H,2-3,6-9,12-16H2,1H3,(H,26,27,28)/t19?,20-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336421
PNG
(US9744172, Compound UNC1170A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H37N7O2/c1-2-3-12-29-27-30-17-23-24(32-34(25(23)31-27)18-19-4-10-22(28)11-5-19)20-6-8-21(9-7-20)26(35)33-13-15-36-16-14-33/h6-9,17,19,22H,2-5,10-16,18,28H2,1H3,(H,29,30,31)/t19?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336422
PNG
(US9744172, Compound UNC1179A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)NC
Show InChI InChI=1S/C24H33N7O/c1-3-4-13-27-24-28-14-20-21(17-7-9-18(10-8-17)23(32)26-2)30-31(22(20)29-24)15-16-5-11-19(25)12-6-16/h7-10,14,16,19H,3-6,11-13,15,25H2,1-2H3,(H,26,32)(H,27,28,29)/t16?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336443
PNG
(US9744172, Compound UNC1185A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NC1CCCC1
Show InChI InChI=1S/C28H39N7O4S/c1-2-3-16-29-28-30-17-24-26(34-35(27(24)33-28)21-10-12-22(36)13-11-21)19-8-14-23(15-9-19)40(38,39)31-18-25(37)32-20-6-4-5-7-20/h8-9,14-15,17,20-22,31,36H,2-7,10-13,16,18H2,1H3,(H,32,37)(H,29,30,33)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336452
PNG
(US9744172, Compound UNC1222A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NC2CCCC2)cc1
Show InChI InChI=1S/C27H37N7O2/c1-2-3-16-28-26-29-17-23-24(33-34(25(23)32-26)21-12-14-22(35)15-13-21)18-8-10-20(11-9-18)31-27(36)30-19-6-4-5-7-19/h8-11,17,19,21-22,35H,2-7,12-16H2,1H3,(H,28,29,32)(H2,30,31,36)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336461
PNG
(US9744172, Compound UNC1149A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C25H33FN6O2/c1-2-3-10-27-25-28-16-20-23(30-32(24(20)29-25)18-5-7-19(33)8-6-18)17-4-9-22(21(26)15-17)31-11-13-34-14-12-31/h4,9,15-16,18-19,33H,2-3,5-8,10-14H2,1H3,(H,27,28,29)/t18?,19-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336470
PNG
(US9744172, Compound UNC1269A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCCCC1
Show InChI InChI=1S/C30H43N7O4S/c1-2-3-18-31-30-32-20-26-28(36-37(29(26)35-30)23-11-13-24(38)14-12-23)21-9-15-25(16-10-21)42(40,41)33-19-17-27(39)34-22-7-5-4-6-8-22/h9-10,15-16,20,22-24,33,38H,2-8,11-14,17-19H2,1H3,(H,34,39)(H,31,32,35)/t23?,24-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336472
PNG
(US9744172, Compound UNC1234A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C21H28N6O/c1-2-3-12-23-21-24-13-18-19(14-4-6-15(22)7-5-14)26-27(20(18)25-21)16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12,22H2,1H3,(H,23,24,25)/t16?,17-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336478
PNG
(US9744172, Compound UNC1284A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCCCC1
Show InChI InChI=1S/C29H41N7O4S/c1-2-3-16-30-29-31-20-25-27(34-36(28(25)33-29)22-9-11-23(37)12-10-22)21-7-13-24(14-8-21)41(39,40)32-17-15-26(38)35-18-5-4-6-19-35/h7-8,13-14,20,22-23,32,37H,2-6,9-12,15-19H2,1H3,(H,30,31,33)/t22?,23-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336512
PNG
(US9744172, Compound UNC1285A)
Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCN(CC)CC2)c(F)c1
Show InChI InChI=1S/C27H38FN7O/c1-3-5-12-29-27-30-18-22-25(32-35(26(22)31-27)20-7-9-21(36)10-8-20)19-6-11-24(23(28)17-19)34-15-13-33(4-2)14-16-34/h6,11,17-18,20-21,36H,3-5,7-10,12-16H2,1-2H3,(H,29,30,31)/t20-,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336260
PNG
(US9744172, Compound UNC00000569A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15?,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336262
PNG
(US9744172, Compound UNC583A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H38N8/c1-2-3-12-29-26-30-17-23-24(20-6-10-22(11-7-20)33-15-13-28-14-16-33)32-34(25(23)31-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21,28H,2-5,8-9,12-16,18,27H2,1H3,(H,29,30,31)/t19?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336281
PNG
(US9744172, Compound UNC605A)
Show SMILES O[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H39N7O/c39-27-14-8-24(9-15-27)22-38-30-28(21-34-31(35-30)33-16-4-7-23-5-2-1-3-6-23)29(36-38)25-10-12-26(13-11-25)37-19-17-32-18-20-37/h1-3,5-6,10-13,21,24,27,32,39H,4,7-9,14-20,22H2,(H,33,34,35)/t24-,27-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336323
PNG
(US9744172, Compound UNC00000475A)
Show SMILES CCCCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C24H34N6/c1-2-3-4-8-15-26-24-27-16-21-22(19-9-6-5-7-10-19)29-30(23(21)28-24)17-18-11-13-20(25)14-12-18/h5-7,9-10,16,18,20H,2-4,8,11-15,17,25H2,1H3,(H,26,27,28)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336366
PNG
(US9744172, Compound UNC973A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCC
Show InChI InChI=1S/C25H36N6O3S/c1-3-5-15-26-25-27-17-22-23(30-31(24(22)29-25)19-9-11-20(32)12-10-19)18-7-13-21(14-8-18)35(33,34)28-16-6-4-2/h7-8,13-14,17,19-20,28,32H,3-6,9-12,15-16H2,1-2H3,(H,26,27,29)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336408
PNG
(US9744172, Compound UNC1085A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(CN2CCOCC2)c(F)c1
Show InChI InChI=1S/C27H38FN7O/c1-2-3-10-30-27-31-16-23-25(33-35(26(23)32-27)17-19-4-8-22(29)9-5-19)20-6-7-21(24(28)15-20)18-34-11-13-36-14-12-34/h6-7,15-16,19,22H,2-5,8-14,17-18,29H2,1H3,(H,30,31,32)/t19-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336430
PNG
(US9744172, Compound UNC1095A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C28H41N7O4S/c1-2-3-13-29-28-30-20-25-26(33-35(27(25)32-28)22-7-9-23(36)10-8-22)21-5-11-24(12-6-21)40(37,38)31-14-4-15-34-16-18-39-19-17-34/h5-6,11-12,20,22-23,31,36H,2-4,7-10,13-19H2,1H3,(H,29,30,32)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336437
PNG
(US9744172, Compound UNC1174A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C32H47N7O5S/c1-5-6-17-33-30-34-21-27-28(37-39(29(27)36-30)24-9-11-25(40)12-10-24)23-7-13-26(14-8-23)45(42,43)35-20-22-15-18-38(19-16-22)31(41)44-32(2,3)4/h7-8,13-14,21-22,24-25,35,40H,5-6,9-12,15-20H2,1-4H3,(H,33,34,36)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336450
PNG
(US9744172, Compound UNC1192A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NCCC)cc1
Show InChI InChI=1S/C25H35N7O2/c1-3-5-15-26-24-28-16-21-22(17-6-8-18(9-7-17)29-25(34)27-14-4-2)31-32(23(21)30-24)19-10-12-20(33)13-11-19/h6-9,16,19-20,33H,3-5,10-15H2,1-2H3,(H,26,28,30)(H2,27,29,34)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336457
PNG
(US9744172, Compound UNC1145A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H43N7O4S/c1-2-3-14-31-30-32-21-27-28(34-37(29(27)33-30)24-6-8-25(38)9-7-24)22-4-10-26(11-5-22)42(39,40)36-15-12-23(13-16-36)35-17-19-41-20-18-35/h4-5,10-11,21,23-25,38H,2-3,6-9,12-20H2,1H3,(H,31,32,33)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336477
PNG
(US9744172, Compound UNC1283A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCCCC1
Show InChI InChI=1S/C29H41N7O4S/c1-2-3-16-30-29-31-20-25-27(34-36(28(25)33-29)22-9-11-23(37)12-10-22)21-7-13-24(14-8-21)41(39,40)32-17-15-26(38)35-18-5-4-6-19-35/h7-8,13-14,20,22-23,32,37H,2-6,9-12,15-19H2,1H3,(H,30,31,33)/t22?,23-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336500
PNG
(US9744172, Compound UNC1344A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(CC)=C1C(=O)OC
Show InChI InChI=1S/C29H37N7O4/c1-4-6-15-30-28-31-16-21-24(35-36(26(21)34-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-3)22(5-2)32-29(39)33-25/h7-10,16,19-20,25,37H,4-6,11-15H2,1-3H3,(H,30,31,34)(H2,32,33,39)/t19?,20-,25?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336503
PNG
(US9744172, Compound UNC1347A)
Show SMILES CCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(CC)=C1C(=O)OC
Show InChI InChI=1S/C29H37N7O4/c1-5-15-30-28-31-16-21-24(34-36(26(21)33-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-4)22(6-2)35(3)29(39)32-25/h7-10,16,19-20,25,37H,5-6,11-15H2,1-4H3,(H,32,39)(H,30,31,33)/t19?,20-,25?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336505
PNG
(US9744172, Compound UNC1349A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(=O)OC
Show InChI InChI=1S/C28H35N7O4/c1-4-5-14-29-27-30-15-21-23(34-35(25(21)33-27)19-10-12-20(36)13-11-19)17-6-8-18(9-7-17)24-22(26(37)39-3)16(2)31-28(38)32-24/h6-9,15,19-20,24,36H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t19?,20-,24?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336511
PNG
(US9744172, Compound UNC1229A)
Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC[C@@H](O)CO
Show InChI InChI=1S/C24H34N6O5S/c1-2-3-12-25-24-26-14-21-22(29-30(23(21)28-24)17-6-8-18(32)9-7-17)16-4-10-20(11-5-16)36(34,35)27-13-19(33)15-31/h4-5,10-11,14,17-19,27,31-33H,2-3,6-9,12-13,15H2,1H3,(H,25,26,28)/t17-,18-,19-/m1/s1
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336265
PNG
(US9744172, Compound UNC580A)
Show SMILES N[C@H]1CCC(Cn2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C27H31FN6/c28-22-12-10-21(11-13-22)25-24-17-31-27(30-16-4-7-19-5-2-1-3-6-19)32-26(24)34(33-25)18-20-8-14-23(29)15-9-20/h1-3,5-6,10-13,17,20,23H,4,7-9,14-16,18,29H2,(H,30,31,32)/t20?,23-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336270
PNG
(US9744172, Compound UNC593A)
Show SMILES CCCCNc1ncc2c(nn(C[C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-8-21(9-7-20)32-15-13-27-14-16-32)31-33(25(23)30-26)18-19-4-10-22(34)11-5-19/h6-9,17,19,22,27,34H,2-5,10-16,18H2,1H3,(H,28,29,30)/t19-,22+
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384602
PNG
(CHEMBL2036795 | US9744172, Compound UNC00000344A)
Show SMILES CCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C22H30N6/c1-2-3-13-24-22-25-14-19-20(17-7-5-4-6-8-17)27-28(21(19)26-22)15-16-9-11-18(23)12-10-16/h4-8,14,16,18H,2-3,9-13,15,23H2,1H3,(H,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336364
PNG
(US9744172, Compound UNC971A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCCC1
Show InChI InChI=1S/C27H38N6O3S/c1-2-3-17-28-27-29-18-24-25(31-33(26(24)30-27)21-11-13-22(34)14-12-21)19-9-15-23(16-10-19)37(35,36)32-20-7-5-4-6-8-20/h9-10,15-16,18,20-22,32,34H,2-8,11-14,17H2,1H3,(H,28,29,30)/t21?,22-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336381
PNG
(US9744172, Compound UNC1036A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C26H36N6O3S/c1-2-3-16-27-26-28-17-23-24(30-32(25(23)29-26)20-10-12-21(33)13-11-20)18-8-14-22(15-9-18)36(34,35)31-19-6-4-5-7-19/h8-9,14-15,17,19-21,31,33H,2-7,10-13,16H2,1H3,(H,27,28,29)/t20?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336401
PNG
(US9744172, Compound UNC913A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C23H33N7O2S/c1-3-4-13-26-23-27-14-20-21(17-7-11-19(12-8-17)33(31,32)25-2)29-30(22(20)28-23)15-16-5-9-18(24)10-6-16/h7-8,11-12,14,16,18,25H,3-6,9-10,13,15,24H2,1-2H3,(H,26,27,28)/t16-,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336423
PNG
(US9744172, Compound UNC1171A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H37N7O/c1-2-3-14-29-27-30-17-23-24(20-8-10-21(11-9-20)26(35)33-15-4-5-16-33)32-34(25(23)31-27)18-19-6-12-22(28)13-7-19/h8-11,17,19,22H,2-7,12-16,18,28H2,1H3,(H,29,30,31)/t19-,22-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336434
PNG
(US9744172, Compound UNC1125A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCc1ccc(F)cc1
Show InChI InChI=1S/C29H35FN6O3S/c1-2-3-17-31-29-32-19-26-27(35-36(28(26)34-29)23-10-12-24(37)13-11-23)21-6-14-25(15-7-21)40(38,39)33-18-16-20-4-8-22(30)9-5-20/h4-9,14-15,19,23-24,33,37H,2-3,10-13,16-18H2,1H3,(H,31,32,34)/t23?,24-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336440
PNG
(US9744172, Compound UNC1177A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C27H36N6O5S/c1-2-3-14-28-27-29-17-23-24(31-33(25(23)30-27)20-6-8-21(34)9-7-20)18-4-10-22(11-5-18)39(37,38)32-15-12-19(13-16-32)26(35)36/h4-5,10-11,17,19-21,34H,2-3,6-9,12-16H2,1H3,(H,35,36)(H,28,29,30)/t20?,21-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336441
PNG
(US9744172, Compound UNC1178A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)C(=O)OC
Show InChI InChI=1S/C28H38N6O5S/c1-3-4-15-29-28-30-18-24-25(32-34(26(24)31-28)21-7-9-22(35)10-8-21)19-5-11-23(12-6-19)40(37,38)33-16-13-20(14-17-33)27(36)39-2/h5-6,11-12,18,20-22,35H,3-4,7-10,13-17H2,1-2H3,(H,29,30,31)/t21?,22-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336445
PNG
(US9744172, Compound UNC1187A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C28H34N6O3S/c1-3-4-17-29-28-30-18-25-26(32-34(27(25)31-28)22-11-13-23(35)14-12-22)20-7-15-24(16-8-20)38(36,37)33-21-9-5-19(2)6-10-21/h5-10,15-16,18,22-23,33,35H,3-4,11-14,17H2,1-2H3,(H,29,30,31)/t22?,23-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336456
PNG
(US9744172, Compound UNC1144A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C31H45N7O3S/c1-2-3-17-32-31-33-22-28-29(35-38(30(28)34-31)25-9-11-26(39)12-10-25)23-7-13-27(14-8-23)42(40,41)37-20-15-24(16-21-37)36-18-5-4-6-19-36/h7-8,13-14,22,24-26,39H,2-6,9-12,15-21H2,1H3,(H,32,33,34)/t25?,26-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336475
PNG
(US9744172, Compound UNC1281A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCOCC1
Show InChI InChI=1S/C28H39N7O5S/c1-2-3-13-29-28-30-19-24-26(33-35(27(24)32-28)21-6-8-22(36)9-7-21)20-4-10-23(11-5-20)41(38,39)31-14-12-25(37)34-15-17-40-18-16-34/h4-5,10-11,19,21-22,31,36H,2-3,6-9,12-18H2,1H3,(H,29,30,32)/t21?,22-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336498
PNG
(US9744172, Compound UNC1326A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(C)=O
Show InChI InChI=1S/C28H35N7O3/c1-4-5-14-29-27-30-15-22-24(34-35(26(22)33-27)20-10-12-21(37)13-11-20)18-6-8-19(9-7-18)25-23(17(3)36)16(2)31-28(38)32-25/h6-9,15,20-21,25,37H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t20?,21-,25?
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%