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Patent code US9745283

Compile Data Set for Download or QSAR

Found 328 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336598
PNG
(US9745283, Example 32)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)n2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H25F2N5O6/c1-5-36-16(2)26(29(39)37(30(36)40)18-8-6-17(31)7-9-18)28(38)35-25-11-10-22(27(32)34-25)43-21-12-13-33-20-15-24(42-4)23(41-3)14-19(20)21/h6-15H,5H2,1-4H3,(H,34,35,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336618
PNG
(US9745283, Example 49)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H24F2N4O7/c1-41-26-14-20-23(15-27(26)42-2)33-10-9-24(20)43-25-8-5-18(13-22(25)32)34-28(38)21-16-35(11-12-37)30(40)36(29(21)39)19-6-3-17(31)4-7-19/h3-10,13-16,37H,11-12H2,1-2H3,(H,34,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336620
PNG
(US9745283, Example 51)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCCO)c(=O)n(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC
Show InChI InChI=1S/C32H28F2N4O7/c1-43-28-16-22-26(17-29(28)44-2)35-12-11-27(22)45-21-9-10-25(24(34)15-21)36-30(40)23-18-37(13-3-4-14-39)32(42)38(31(23)41)20-7-5-19(33)6-8-20/h5-12,15-18,39H,3-4,13-14H2,1-2H3,(H,36,40)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336622
PNG
(US9745283, Example 53)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)c2cc1OC
Show InChI InChI=1S/C30H25FN4O7/c1-40-26-15-22-24(16-27(26)41-2)32-12-11-25(22)42-21-9-5-19(6-10-21)33-28(37)23-17-34(13-14-36)30(39)35(29(23)38)20-7-3-18(31)4-8-20/h3-12,15-17,36H,13-14H2,1-2H3,(H,33,37)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336630
PNG
(US9745283, Example 61)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC#C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h1,5-12,14-17H,13H2,2-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336635
PNG
(US9745283, Example 65)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCC5OCCO5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H28F2N4O8/c1-43-28-16-22-25(17-29(28)44-2)36-11-9-26(22)47-27-8-5-20(15-24(27)35)37-31(40)23-18-38(12-10-30-45-13-14-46-30)33(42)39(32(23)41)21-6-3-19(34)4-7-21/h3-9,11,15-18,30H,10,12-14H2,1-2H3,(H,37,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336641
PNG
(US9745283, Example 71)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC(O)=O)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H22F2N4O8/c1-42-25-12-19-22(13-26(25)43-2)33-10-9-23(19)44-24-8-5-17(11-21(24)32)34-28(39)20-14-35(15-27(37)38)30(41)36(29(20)40)18-6-3-16(31)4-7-18/h3-14H,15H2,1-2H3,(H,34,39)(H,37,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336644
PNG
(US9745283, Example 74)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC5CCOCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H30F2N4O7/c1-44-30-16-24-27(17-31(30)45-2)37-12-9-28(24)47-29-8-5-22(15-26(29)36)38-32(41)25-19-39(18-20-10-13-46-14-11-20)34(43)40(33(25)42)23-6-3-21(35)4-7-23/h3-9,12,15-17,19-20H,10-11,13-14,18H2,1-2H3,(H,38,41)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336674
PNG
(US9745283, Example 103)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H25F2N5O6/c1-16(2)37-30(40)36(19-8-5-17(31)6-9-19)29(39)27(35-37)28(38)34-18-7-10-24(21(32)13-18)43-23-11-12-33-22-15-26(42-4)25(41-3)14-20(22)23/h5-16H,1-4H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336675
PNG
(US9745283, Example 104)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C28H21F2N5O6/c1-34-28(38)35(17-7-4-15(29)5-8-17)27(37)25(33-34)26(36)32-16-6-9-22(19(30)12-16)41-21-10-11-31-20-14-24(40-3)23(39-2)13-18(20)21/h4-14H,1-3H3,(H,32,36)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336536
PNG
(US9745283, Example 9)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC=C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H24F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h4-12,14-17H,1,13H2,2-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336549
PNG
(US9745283, Example 17)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c[nH]c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C28H20F2N4O6/c1-38-24-12-18-21(13-25(24)39-2)31-10-9-22(18)40-23-8-5-16(11-20(23)30)33-26(35)19-14-32-28(37)34(27(19)36)17-6-3-15(29)4-7-17/h3-14H,1-2H3,(H,32,37)(H,33,35)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336582
PNG
(US9745283, Example 20)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H29F2N5O6/c1-37(2)13-14-38-18-23(31(41)39(32(38)42)21-8-5-19(33)6-9-21)30(40)36-20-7-10-27(24(34)15-20)45-26-11-12-35-25-17-29(44-4)28(43-3)16-22(25)26/h5-12,15-18H,13-14H2,1-4H3,(H,36,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336593
PNG
(US9745283, Example 27)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN5CCCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C35H33F2N5O6/c1-46-31-19-25-28(20-32(31)47-2)38-13-12-29(25)48-30-11-8-23(18-27(30)37)39-33(43)26-21-41(17-16-40-14-4-3-5-15-40)35(45)42(34(26)44)24-9-6-22(36)7-10-24/h6-13,18-21H,3-5,14-17H2,1-2H3,(H,39,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336594
PNG
(US9745283, Example 28)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H25FN4O6/c1-4-34-17-23(29(37)35(30(34)38)20-9-5-18(31)6-10-20)28(36)33-19-7-11-21(12-8-19)41-25-13-14-32-24-16-27(40-3)26(39-2)15-22(24)25/h5-17H,4H2,1-3H3,(H,33,36)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336595
PNG
(US9745283, Example 29)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H26F2N4O6/c1-42-28-15-22-25(16-29(28)43-2)35-13-12-26(22)44-27-11-8-19(14-24(27)34)36-30(39)23-17-37(20-4-3-5-20)32(41)38(31(23)40)21-9-6-18(33)7-10-21/h6-17,20H,3-5H2,1-2H3,(H,36,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336619
PNG
(US9745283, Example 50)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H26F2N4O7/c1-42-27-15-21-24(16-28(27)43-2)34-11-10-25(21)44-26-9-6-19(14-23(26)33)35-29(39)22-17-36(12-3-13-38)31(41)37(30(22)40)20-7-4-18(32)5-8-20/h4-11,14-17,38H,3,12-13H2,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336619
PNG
(US9745283, Example 50)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H26F2N4O7/c1-42-27-15-21-24(16-28(27)43-2)34-11-10-25(21)44-26-9-6-19(14-23(26)33)35-29(39)22-17-36(12-3-13-38)31(41)37(30(22)40)20-7-4-18(32)5-8-20/h4-11,14-17,38H,3,12-13H2,1-2H3,(H,35,39)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336630
PNG
(US9745283, Example 61)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC#C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h1,5-12,14-17H,13H2,2-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336631
PNG
(US9745283, Example 62)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCn5ccnc5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H26F2N6O6/c1-45-29-16-23-26(17-30(29)46-2)37-10-9-27(23)47-28-8-5-21(15-25(28)35)38-31(42)24-18-40(14-13-39-12-11-36-19-39)33(44)41(32(24)43)22-6-3-20(34)4-7-22/h3-12,15-19H,13-14H2,1-2H3,(H,38,42)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336636
PNG
(US9745283, Example 66)
Show SMILES CCN(CC)C(=O)Cn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H31F2N5O7/c1-5-39(6-2)31(42)19-40-18-24(33(44)41(34(40)45)22-10-7-20(35)8-11-22)32(43)38-21-9-12-28(25(36)15-21)48-27-13-14-37-26-17-30(47-4)29(46-3)16-23(26)27/h7-18H,5-6,19H2,1-4H3,(H,38,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336638
PNG
(US9745283, Example 68)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN5CCCC5=O)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H29F2N5O7/c1-46-29-17-23-26(18-30(29)47-2)37-12-11-27(23)48-28-10-7-21(16-25(28)36)38-32(43)24-19-40(15-14-39-13-3-4-31(39)42)34(45)41(33(24)44)22-8-5-20(35)6-9-22/h5-12,16-19H,3-4,13-15H2,1-2H3,(H,38,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336639
PNG
(US9745283, Example 69)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCF)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H23F3N4O6/c1-41-26-14-20-23(15-27(26)42-2)34-11-9-24(20)43-25-8-5-18(13-22(25)33)35-28(38)21-16-36(12-10-31)30(40)37(29(21)39)19-6-3-17(32)4-7-19/h3-9,11,13-16H,10,12H2,1-2H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336671
PNG
(US9745283, Example 100)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C30H25FN4O6/c1-4-34-17-21(29(37)35(30(34)38)19-8-6-5-7-9-19)28(36)33-18-10-11-25(22(31)14-18)41-24-12-13-32-23-16-27(40-3)26(39-2)15-20(23)24/h5-17H,4H2,1-3H3,(H,33,36)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336672
PNG
(US9745283, Example 101)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccccc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H27FN4O6/c1-18(2)35-17-22(30(38)36(31(35)39)20-8-6-5-7-9-20)29(37)34-19-10-11-26(23(32)14-19)42-25-12-13-33-24-16-28(41-4)27(40-3)15-21(24)25/h5-18H,1-4H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336539
PNG
(US9745283, Example 102 | US9745283, Example 11)
Show SMILES CCCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h5-12,14-17H,4,13H2,1-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336682
PNG
(US9745283, Example 111)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4nn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C29H23F2N5O5/c1-16(2)36-29(39)35(19-7-4-17(30)5-8-19)28(38)26(34-36)27(37)33-18-6-11-25(22(31)14-18)41-24-12-13-32-23-15-20(40-3)9-10-21(23)24/h4-16H,1-3H3,(H,33,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336720
PNG
(US9745283, Example 149)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c[nH]c(=O)n(-c5ccc(F)cc5)c4=O)cc3C)c2cc1OC
Show InChI InChI=1S/C29H23FN4O6/c1-16-12-18(33-27(35)21-15-32-29(37)34(28(21)36)19-7-4-17(30)5-8-19)6-9-23(16)40-24-10-11-31-22-14-26(39-3)25(38-2)13-20(22)24/h4-15H,1-3H3,(H,32,37)(H,33,35)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336723
PNG
(US9745283, Example 152)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(Cl)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H24ClFN4O6/c1-4-35-16-21(29(38)36(30(35)39)19-8-5-17(32)6-9-19)28(37)34-18-7-10-25(22(31)13-18)42-24-11-12-33-23-15-27(41-3)26(40-2)14-20(23)24/h5-16H,4H2,1-3H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336742
PNG
(US9745283, Example 171)
Show SMILES CCn1nc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H21F2N5O5/c1-3-34-28(38)35(18-7-4-16(29)5-8-18)27(37)25(33-34)26(36)32-17-6-11-24(21(30)14-17)40-23-12-13-31-22-15-19(39-2)9-10-20(22)23/h4-15H,3H2,1-2H3,(H,32,36)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336529
PNG
(US9745283, Example 3)
Show SMILES COCCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26F2N4O7/c1-41-13-12-36-17-22(30(39)37(31(36)40)20-7-4-18(32)5-8-20)29(38)35-19-6-9-26(23(33)14-19)44-25-10-11-34-24-16-28(43-3)27(42-2)15-21(24)25/h4-11,14-17H,12-13H2,1-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336530
PNG
(US9745283, Example 4)
Show SMILES CCOCCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H28F2N4O7/c1-4-44-14-13-37-18-23(31(40)38(32(37)41)21-8-5-19(33)6-9-21)30(39)36-20-7-10-27(24(34)15-20)45-26-11-12-35-25-17-29(43-3)28(42-2)16-22(25)26/h5-12,15-18H,4,13-14H2,1-3H3,(H,36,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336584
PNG
(US9745283, Example 22)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCOCc5ccccc5)c(=O)n(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC
Show InChI InChI=1S/C38H32F2N4O7/c1-48-34-20-28-32(21-35(34)49-2)41-16-15-33(28)51-27-13-14-31(30(40)19-27)42-36(45)29-22-43(17-6-18-50-23-24-7-4-3-5-8-24)38(47)44(37(29)46)26-11-9-25(39)10-12-26/h3-5,7-16,19-22H,6,17-18,23H2,1-2H3,(H,42,45)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336586
PNG
(US9745283, Example 23)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)c2cc1OC
Show InChI InChI=1S/C31H27FN4O6/c1-18(2)35-17-24(30(38)36(31(35)39)21-9-5-19(32)6-10-21)29(37)34-20-7-11-22(12-8-20)42-26-13-14-33-25-16-28(41-4)27(40-3)15-23(25)26/h5-18H,1-4H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336598
PNG
(US9745283, Example 32)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)n2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H25F2N5O6/c1-5-36-16(2)26(29(39)37(30(36)40)18-8-6-17(31)7-9-18)28(38)35-25-11-10-22(27(32)34-25)43-21-12-13-33-20-15-24(42-4)23(41-3)14-19(20)21/h6-15H,5H2,1-4H3,(H,34,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336620
PNG
(US9745283, Example 51)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCCO)c(=O)n(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC
Show InChI InChI=1S/C32H28F2N4O7/c1-43-28-16-22-26(17-29(28)44-2)35-12-11-27(22)45-21-9-10-25(24(34)15-21)36-30(40)23-18-37(13-3-4-14-39)32(42)38(31(23)41)20-7-5-19(33)6-8-20/h5-12,15-18,39H,3-4,13-14H2,1-2H3,(H,36,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336633
PNG
(US9745283, Example 64)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCc5ccccc5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C36H28F2N4O6/c1-46-32-19-26-29(20-33(32)47-2)39-16-14-30(26)48-31-13-10-24(18-28(31)38)40-34(43)27-21-41(17-15-22-6-4-3-5-7-22)36(45)42(35(27)44)25-11-8-23(37)9-12-25/h3-14,16,18-21H,15,17H2,1-2H3,(H,40,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336637
PNG
(US9745283, Example 67)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC(=O)N5CCOCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H29F2N5O8/c1-46-29-16-23-26(17-30(29)47-2)37-10-9-27(23)49-28-8-5-21(15-25(28)36)38-32(43)24-18-40(19-31(42)39-11-13-48-14-12-39)34(45)41(33(24)44)22-6-3-20(35)4-7-22/h3-10,15-18H,11-14,19H2,1-2H3,(H,38,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336642
PNG
(US9745283, Example 72)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(Cc5ncco5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H23F2N5O7/c1-43-27-14-21-24(15-28(27)44-2)35-10-9-25(21)46-26-8-5-19(13-23(26)34)37-30(40)22-16-38(17-29-36-11-12-45-29)32(42)39(31(22)41)20-6-3-18(33)4-7-20/h3-16H,17H2,1-2H3,(H,37,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336652
PNG
(US9745283, Example 82)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC(=O)N5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H29F2N5O7/c1-46-29-16-23-26(17-30(29)47-2)37-12-11-27(23)48-28-10-7-21(15-25(28)36)38-32(43)24-18-40(19-31(42)39-13-3-4-14-39)34(45)41(33(24)44)22-8-5-20(35)6-9-22/h5-12,15-18H,3-4,13-14,19H2,1-2H3,(H,38,43)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336662
PNG
(US9745283, Example 91)
Show SMILES CCn1c(=O)c(cn(-c2ccc(F)cc2)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
Show InChI InChI=1S/C30H24F2N4O6/c1-4-35-29(38)21(16-36(30(35)39)19-8-5-17(31)6-9-19)28(37)34-18-7-10-25(22(32)13-18)42-24-11-12-33-23-15-27(41-3)26(40-2)14-20(23)24/h5-16H,4H2,1-3H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336669
PNG
(US9745283, Example 98)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC#C)c(=O)n(CC#C)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C28H21FN4O6/c1-5-11-32-16-19(27(35)33(12-6-2)28(32)36)26(34)31-17-7-8-23(20(29)13-17)39-22-9-10-30-21-15-25(38-4)24(37-3)14-18(21)22/h1-2,7-10,13-16H,11-12H2,3-4H3,(H,31,34)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336701
PNG
(US9745283, Example 130)
Show SMILES CCC(C)Cn1c(=O)c(nn(C)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
Show InChI InChI=1S/C27H28FN5O6/c1-6-15(2)14-33-26(35)24(31-32(3)27(33)36)25(34)30-16-7-8-21(18(28)11-16)39-20-9-10-29-19-13-23(38-5)22(37-4)12-17(19)20/h7-13,15H,6,14H2,1-5H3,(H,30,34)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336718
PNG
(US9745283, Example 147)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2F)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H23F3N4O6/c1-4-36-15-19(29(39)37(30(36)40)17-7-5-16(31)6-8-17)28(38)35-20-9-10-23(27(33)26(20)32)43-22-11-12-34-21-14-25(42-3)24(41-2)13-18(21)22/h5-15H,4H2,1-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336722
PNG
(US9745283, Example 151)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(OC)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H27FN4O7/c1-5-35-17-22(30(38)36(31(35)39)20-9-6-18(32)7-10-20)29(37)34-19-8-11-25(26(14-19)40-2)43-24-12-13-33-23-16-28(42-4)27(41-3)15-21(23)24/h6-17H,5H2,1-4H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336735
PNG
(US9745283, Example 164)
Show SMILES CCn1nc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H23FN6O6/c1-4-34-28(38)35(17-7-5-16(29)6-8-17)27(37)25(33-34)26(36)32-24-10-9-18(15-31-24)41-21-11-12-30-20-14-23(40-3)22(39-2)13-19(20)21/h5-15H,4H2,1-3H3,(H,31,32,36)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336527
PNG
(US9745283, Example 2)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C29H22F2N4O6/c1-34-15-20(28(37)35(29(34)38)18-7-4-16(30)5-8-18)27(36)33-17-6-9-24(21(31)12-17)41-23-10-11-32-22-14-26(40-3)25(39-2)13-19(22)23/h4-15H,1-3H3,(H,33,36)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336533
PNG
(US9745283, Example 6)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H26F2N4O6/c1-42-28-14-22-25(15-29(28)43-2)35-12-11-26(22)44-27-10-7-20(13-24(27)34)36-30(39)23-17-37(16-18-3-4-18)32(41)38(31(23)40)21-8-5-19(33)6-9-21/h5-15,17-18H,3-4,16H2,1-2H3,(H,36,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336535
PNG
(US9745283, Example 8)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H28F2N4O6/c1-18(2)16-37-17-23(31(40)38(32(37)41)21-8-5-19(33)6-9-21)30(39)36-20-7-10-27(24(34)13-20)44-26-11-12-35-25-15-29(43-4)28(42-3)14-22(25)26/h5-15,17-18H,16H2,1-4H3,(H,36,39)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336592
PNG
(US9745283, Example 26)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H31F2N5O6/c1-45-30-18-24-27(19-31(30)46-2)37-12-11-28(24)47-29-10-7-22(17-26(29)36)38-32(42)25-20-40(16-15-39-13-3-4-14-39)34(44)41(33(25)43)23-8-5-21(35)6-9-23/h5-12,17-20H,3-4,13-16H2,1-2H3,(H,38,42)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 328 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%