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Patent code US9745283

Compile Data Set for Download or QSAR

Found 328 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336620
PNG
(US9745283, Example 51)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCCO)c(=O)n(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC
Show InChI InChI=1S/C32H28F2N4O7/c1-43-28-16-22-26(17-29(28)44-2)35-12-11-27(22)45-21-9-10-25(24(34)15-21)36-30(40)23-18-37(13-3-4-14-39)32(42)38(31(23)41)20-7-5-19(33)6-8-20/h5-12,15-18,39H,3-4,13-14H2,1-2H3,(H,36,40)
PDB
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US Patent
n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336622
PNG
(US9745283, Example 53)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)c2cc1OC
Show InChI InChI=1S/C30H25FN4O7/c1-40-26-15-22-24(16-27(26)41-2)32-12-11-25(22)42-21-9-5-19(6-10-21)33-28(37)23-17-34(13-14-36)30(39)35(29(23)38)20-7-3-18(31)4-8-20/h3-12,15-17,36H,13-14H2,1-2H3,(H,33,37)
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US Patent
n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336627
PNG
(US9745283, Example 58)
Show SMILES COc1cc2nccc(Cc3ccc(NC(=O)c4cn(C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H24F2N4O5/c1-35-16-23(29(38)36(30(35)39)21-8-5-19(31)6-9-21)28(37)34-20-7-4-18(24(32)13-20)12-17-10-11-33-25-15-27(41-3)26(40-2)14-22(17)25/h4-11,13-16H,12H2,1-3H3,(H,34,37)
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US Patent
n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336630
PNG
(US9745283, Example 61)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC#C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h1,5-12,14-17H,13H2,2-3H3,(H,35,38)
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US Patent
n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336631
PNG
(US9745283, Example 62)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCn5ccnc5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H26F2N6O6/c1-45-29-16-23-26(17-30(29)46-2)37-10-9-27(23)47-28-8-5-21(15-25(28)35)38-31(42)24-18-40(14-13-39-12-11-36-19-39)33(44)41(32(24)43)22-6-3-20(34)4-7-22/h3-12,15-19H,13-14H2,1-2H3,(H,38,42)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336641
PNG
(US9745283, Example 71)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC(O)=O)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H22F2N4O8/c1-42-25-12-19-22(13-26(25)43-2)33-10-9-23(19)44-24-8-5-17(11-21(24)32)34-28(39)20-14-35(15-27(37)38)30(41)36(29(20)40)18-6-3-16(31)4-7-18/h3-14H,15H2,1-2H3,(H,34,39)(H,37,38)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336643
PNG
(US9745283, Example 73)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC5CCCO5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H28F2N4O7/c1-43-29-15-23-26(16-30(29)44-2)36-12-11-27(23)46-28-10-7-20(14-25(28)35)37-31(40)24-18-38(17-22-4-3-13-45-22)33(42)39(32(24)41)21-8-5-19(34)6-9-21/h5-12,14-16,18,22H,3-4,13,17H2,1-2H3,(H,37,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336645
PNG
(US9745283, Example 75)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(Cc5csc(C)n5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H25F2N5O6S/c1-18-37-21(17-47-18)15-39-16-24(32(42)40(33(39)43)22-7-4-19(34)5-8-22)31(41)38-20-6-9-28(25(35)12-20)46-27-10-11-36-26-14-30(45-3)29(44-2)13-23(26)27/h4-14,16-17H,15H2,1-3H3,(H,38,41)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336669
PNG
(US9745283, Example 98)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC#C)c(=O)n(CC#C)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C28H21FN4O6/c1-5-11-32-16-19(27(35)33(12-6-2)28(32)36)26(34)31-17-7-8-23(20(29)13-17)39-22-9-10-30-21-15-25(38-4)24(37-3)14-18(21)22/h1-2,7-10,13-16H,11-12H2,3-4H3,(H,31,34)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336675
PNG
(US9745283, Example 104)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C28H21F2N5O6/c1-34-28(38)35(17-7-4-15(29)5-8-17)27(37)25(33-34)26(36)32-16-6-9-22(19(30)12-16)41-21-10-11-31-20-14-24(40-3)23(39-2)13-18(20)21/h4-14H,1-3H3,(H,32,36)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336539
PNG
(US9745283, Example 102 | US9745283, Example 11)
Show SMILES CCCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h5-12,14-17H,4,13H2,1-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336698
PNG
(US9745283, Example 127)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(CC(C)C)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C26H26FN5O6/c1-14(2)13-32-25(34)23(30-31(3)26(32)35)24(33)29-15-6-7-20(17(27)10-15)38-19-8-9-28-18-12-22(37-5)21(36-4)11-16(18)19/h6-12,14H,13H2,1-5H3,(H,29,33)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336720
PNG
(US9745283, Example 149)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c[nH]c(=O)n(-c5ccc(F)cc5)c4=O)cc3C)c2cc1OC
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US Patent
n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336742
PNG
(US9745283, Example 171)
Show SMILES CCn1nc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H21F2N5O5/c1-3-34-28(38)35(18-7-4-16(29)5-8-18)27(37)25(33-34)26(36)32-17-6-11-24(21(30)14-17)40-23-12-13-31-22-15-19(39-2)9-10-20(22)23/h4-15H,3H2,1-2H3,(H,32,36)
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336536
PNG
(US9745283, Example 9)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC=C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H24F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h4-12,14-17H,1,13H2,2-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336539
PNG
(US9745283, Example 102 | US9745283, Example 11)
Show SMILES CCCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h5-12,14-17H,4,13H2,1-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336545
PNG
(US9745283, Example 14)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC=C(F)F)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F4N4O6/c1-43-26-14-20-23(15-27(26)44-2)36-11-9-24(20)45-25-8-5-18(13-22(25)33)37-29(40)21-16-38(12-10-28(34)35)31(42)39(30(21)41)19-6-3-17(32)4-7-19/h3-11,13-16H,12H2,1-2H3,(H,37,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336582
PNG
(US9745283, Example 20)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H29F2N5O6/c1-37(2)13-14-38-18-23(31(41)39(32(38)42)21-8-5-19(33)6-9-21)30(40)36-20-7-10-27(24(34)15-20)45-26-11-12-35-25-17-29(44-4)28(43-3)16-22(25)26/h5-12,15-18H,13-14H2,1-4H3,(H,36,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336583
PNG
(US9745283, Example 21)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCOCc5ccccc5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)c2cc1OC
Show InChI InChI=1S/C38H33FN4O7/c1-47-34-21-30-32(22-35(34)48-2)40-18-17-33(30)50-29-15-11-27(12-16-29)41-36(44)31-23-42(19-6-20-49-24-25-7-4-3-5-8-25)38(46)43(37(31)45)28-13-9-26(39)10-14-28/h3-5,7-18,21-23H,6,19-20,24H2,1-2H3,(H,41,44)
UniProtKB/TrEMBL

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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336595
PNG
(US9745283, Example 29)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C32H26F2N4O6/c1-42-28-15-22-25(16-29(28)43-2)35-13-12-26(22)44-27-11-8-19(14-24(27)34)36-30(39)23-17-37(20-4-3-5-20)32(41)38(31(23)40)21-9-6-18(33)7-10-21/h6-17,20H,3-5H2,1-2H3,(H,36,39)
UniProtKB/TrEMBL

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UniChem
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n/an/a<10n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336596
PNG
(US9745283, Example 30)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C5CCOCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H28F2N4O7/c1-43-29-16-23-26(17-30(29)44-2)36-12-9-27(23)46-28-8-5-20(15-25(28)35)37-31(40)24-18-38(21-10-13-45-14-11-21)33(42)39(32(24)41)22-6-3-19(34)4-7-22/h3-9,12,15-18,21H,10-11,13-14H2,1-2H3,(H,37,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336598
PNG
(US9745283, Example 32)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)n2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H25F2N5O6/c1-5-36-16(2)26(29(39)37(30(36)40)18-8-6-17(31)7-9-18)28(38)35-25-11-10-22(27(32)34-25)43-21-12-13-33-20-15-24(42-4)23(41-3)14-19(20)21/h6-15H,5H2,1-4H3,(H,34,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336607
PNG
(US9745283, Example 39)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)cc(OC)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H24F2N4O6/c1-4-35-16-21(29(38)36(30(35)39)19-8-5-17(31)6-9-19)28(37)34-18-7-10-24(22(32)13-18)42-25-11-12-33-23-14-20(40-2)15-26(41-3)27(23)25/h5-16H,4H2,1-3H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336618
PNG
(US9745283, Example 49)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H24F2N4O7/c1-41-26-14-20-23(15-27(26)42-2)33-10-9-24(20)43-25-8-5-18(13-22(25)32)34-28(38)21-16-35(11-12-37)30(40)36(29(21)39)19-6-3-17(31)4-7-19/h3-10,13-16,37H,11-12H2,1-2H3,(H,34,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336630
PNG
(US9745283, Example 61)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC#C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h1,5-12,14-17H,13H2,2-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336635
PNG
(US9745283, Example 65)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCC5OCCO5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H28F2N4O8/c1-43-28-16-22-25(17-29(28)44-2)36-11-9-26(22)47-27-8-5-20(15-24(27)35)37-31(40)23-18-38(12-10-30-45-13-14-46-30)33(42)39(32(23)41)21-6-3-19(34)4-7-21/h3-9,11,15-18,30H,10,12-14H2,1-2H3,(H,37,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336636
PNG
(US9745283, Example 66)
Show SMILES CCN(CC)C(=O)Cn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H31F2N5O7/c1-5-39(6-2)31(42)19-40-18-24(33(44)41(34(40)45)22-10-7-20(35)8-11-22)32(43)38-21-9-12-28(25(36)15-21)48-27-13-14-37-26-17-30(47-4)29(46-3)16-23(26)27/h7-18H,5-6,19H2,1-4H3,(H,38,43)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336638
PNG
(US9745283, Example 68)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN5CCCC5=O)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H29F2N5O7/c1-46-29-17-23-26(18-30(29)47-2)37-12-11-27(23)48-28-10-7-21(16-25(28)36)38-32(43)24-19-40(15-14-39-13-3-4-31(39)42)34(45)41(33(24)44)22-8-5-20(35)6-9-22/h5-12,16-19H,3-4,13-15H2,1-2H3,(H,38,43)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336648
PNG
(US9745283, Example 78)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCc5ccccc5F)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C36H27F3N4O6/c1-47-32-18-25-29(19-33(32)48-2)40-15-13-30(25)49-31-12-9-23(17-28(31)39)41-34(44)26-20-42(16-14-21-5-3-4-6-27(21)38)36(46)43(35(26)45)24-10-7-22(37)8-11-24/h3-13,15,17-20H,14,16H2,1-2H3,(H,41,44)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336658
PNG
(US9745283, Example 87)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H24F2N4O6/c1-4-35-16-21(29(38)36(30(35)39)18-7-5-17(31)6-8-18)28(37)34-23-10-9-19(13-22(23)32)42-25-11-12-33-24-15-27(41-3)26(40-2)14-20(24)25/h5-16H,4H2,1-3H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336662
PNG
(US9745283, Example 91)
Show SMILES CCn1c(=O)c(cn(-c2ccc(F)cc2)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
Show InChI InChI=1S/C30H24F2N4O6/c1-4-35-29(38)21(16-36(30(35)39)19-8-5-17(31)6-9-19)28(37)34-18-7-10-25(22(32)13-18)42-24-11-12-33-23-15-27(41-3)26(40-2)14-20(23)24/h5-16H,4H2,1-3H3,(H,34,37)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336675
PNG
(US9745283, Example 104)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C28H21F2N5O6/c1-34-28(38)35(17-7-4-15(29)5-8-17)27(37)25(33-34)26(36)32-16-6-9-22(19(30)12-16)41-21-10-11-31-20-14-24(40-3)23(39-2)13-18(20)21/h4-14H,1-3H3,(H,32,36)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336699
PNG
(US9745283, Example 128)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(CC5CCC5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C27H26FN5O6/c1-32-27(36)33(14-15-5-4-6-15)26(35)24(31-32)25(34)30-16-7-8-21(18(28)11-16)39-20-9-10-29-19-13-23(38-3)22(37-2)12-17(19)20/h7-13,15H,4-6,14H2,1-3H3,(H,30,34)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336701
PNG
(US9745283, Example 130)
Show SMILES CCC(C)Cn1c(=O)c(nn(C)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
Show InChI InChI=1S/C27H28FN5O6/c1-6-15(2)14-33-26(35)24(31-32(3)27(33)36)25(34)30-16-7-8-21(18(28)11-16)39-20-9-10-29-19-13-23(38-5)22(37-4)12-17(19)20/h7-13,15H,6,14H2,1-5H3,(H,30,34)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336703
PNG
(US9745283, Example 132)
Show SMILES CCn1nc(C(=O)Nc2ccc(Oc3ccnc4cc5OCCOc5cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H21F2N5O6/c1-2-35-29(39)36(18-6-3-16(30)4-7-18)28(38)26(34-35)27(37)33-17-5-8-23(20(31)13-17)42-22-9-10-32-21-15-25-24(14-19(21)22)40-11-12-41-25/h3-10,13-15H,2,11-12H2,1H3,(H,33,37)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336716
PNG
(US9745283, Example 145)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)c1cn(C(C)C)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H29FN4O7/c1-18(2)36-17-23(31(39)37(32(36)40)20-8-6-19(33)7-9-20)30(38)35-24-11-10-21(14-27(24)41-3)44-26-12-13-34-25-16-29(43-5)28(42-4)15-22(25)26/h6-18H,1-5H3,(H,35,38)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336718
PNG
(US9745283, Example 147)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2F)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H23F3N4O6/c1-4-36-15-19(29(39)37(30(36)40)17-7-5-16(31)6-8-17)28(38)35-20-9-10-23(27(33)26(20)32)43-22-11-12-34-21-14-25(42-3)24(41-2)13-18(21)22/h5-15H,4H2,1-3H3,(H,35,38)
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IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336730
PNG
(US9745283, Example 159)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(c2)C(F)(F)F)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H24F4N4O6/c1-4-38-16-21(29(41)39(30(38)42)19-8-5-17(32)6-9-19)28(40)37-18-7-10-25(22(13-18)31(33,34)35)45-24-11-12-36-23-15-27(44-3)26(43-2)14-20(23)24/h5-16H,4H2,1-3H3,(H,37,40)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336548
PNG
(US9745283, Example 16)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCN5CCOCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H31F2N5O7/c1-45-30-18-24-27(19-31(30)46-2)37-10-9-28(24)48-29-8-5-22(17-26(29)36)38-32(42)25-20-40(12-11-39-13-15-47-16-14-39)34(44)41(33(25)43)23-6-3-21(35)4-7-23/h3-10,17-20H,11-16H2,1-2H3,(H,38,42)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336586
PNG
(US9745283, Example 23)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)c2cc1OC
Show InChI InChI=1S/C31H27FN4O6/c1-18(2)35-17-24(30(38)36(31(35)39)21-9-5-19(32)6-10-21)29(37)34-20-7-11-22(12-8-20)42-26-13-14-33-25-16-28(41-4)27(40-3)15-23(25)26/h5-18H,1-4H3,(H,34,37)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336597
PNG
(US9745283, Example 31)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C29H24FN5O6/c1-4-34-16-21(28(37)35(29(34)38)18-7-5-17(30)6-8-18)27(36)33-26-10-9-19(15-32-26)41-23-11-12-31-22-14-25(40-3)24(39-2)13-20(22)23/h5-16H,4H2,1-3H3,(H,32,33,36)
UniProtKB/TrEMBL

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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336620
PNG
(US9745283, Example 51)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCCO)c(=O)n(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC
Show InChI InChI=1S/C32H28F2N4O7/c1-43-28-16-22-26(17-29(28)44-2)35-12-11-27(22)45-21-9-10-25(24(34)15-21)36-30(40)23-18-37(13-3-4-14-39)32(42)38(31(23)41)20-7-5-19(33)6-8-20/h5-12,15-18,39H,3-4,13-14H2,1-2H3,(H,36,40)
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IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336621
PNG
(US9745283, Example 52)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCCO)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)c2cc1OC
Show InChI InChI=1S/C31H27FN4O7/c1-41-27-16-23-25(17-28(27)42-2)33-13-12-26(23)43-22-10-6-20(7-11-22)34-29(38)24-18-35(14-3-15-37)31(40)36(30(24)39)21-8-4-19(32)5-9-21/h4-13,16-18,37H,3,14-15H2,1-2H3,(H,34,38)
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IGNYTA, INC.

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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336639
PNG
(US9745283, Example 69)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CCF)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C30H23F3N4O6/c1-41-26-14-20-23(15-27(26)42-2)34-11-9-24(20)43-25-8-5-18(13-22(25)33)35-28(38)21-16-36(12-10-31)30(40)37(29(21)39)19-6-3-17(32)4-7-19/h3-9,11,13-16H,10,12H2,1-2H3,(H,35,38)
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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336644
PNG
(US9745283, Example 74)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC5CCOCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C34H30F2N4O7/c1-44-30-16-24-27(17-31(30)45-2)37-12-9-28(24)47-29-8-5-22(15-26(29)36)38-32(41)25-19-39(18-20-10-13-46-14-11-20)34(43)40(33(25)42)23-6-3-21(35)4-7-23/h3-9,12,15-17,19-20H,10-11,13-14,18H2,1-2H3,(H,38,41)
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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336646
PNG
(US9745283, Example 76)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C33H28F2N4O6/c1-43-29-16-23-26(17-30(29)44-2)36-14-13-27(23)45-28-12-9-20(15-25(28)35)37-31(40)24-18-38(21-5-3-4-6-21)33(42)39(32(24)41)22-10-7-19(34)8-11-22/h7-18,21H,3-6H2,1-2H3,(H,37,40)
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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336659
PNG
(US9745283, Example 88)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC=C)c(=O)n(-c5ccc(F)cc5)c4=O)c(F)c3)c2cc1OC
Show InChI InChI=1S/C31H24F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)19-7-5-18(32)6-8-19)29(38)35-24-10-9-20(14-23(24)33)43-26-11-12-34-25-16-28(42-3)27(41-2)15-21(25)26/h4-12,14-17H,1,13H2,2-3H3,(H,35,38)
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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336672
PNG
(US9745283, Example 101)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccccc5)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C31H27FN4O6/c1-18(2)35-17-22(30(38)36(31(35)39)20-8-6-5-7-9-20)29(37)34-19-10-11-26(23(32)14-19)42-25-12-13-33-24-16-28(41-4)27(40-3)15-21(24)25/h5-18H,1-4H3,(H,34,37)
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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor (cMet)


(Homo sapiens (Human))
BDBM336539
PNG
(US9745283, Example 102 | US9745283, Example 11)
Show SMILES CCCn1cc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H26F2N4O6/c1-4-13-36-17-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)14-19)43-25-11-12-34-24-16-28(42-3)27(41-2)15-21(24)25/h5-12,14-17H,4,13H2,1-3H3,(H,35,38)
PDB
MMDB

KEGG

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Assay Description
The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (AXL)


(Homo sapiens (Human))
BDBM336700
PNG
(US9745283, Example 129)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(CC(C)(C)C)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C27H28FN5O6/c1-27(2,3)14-33-25(35)23(31-32(4)26(33)36)24(34)30-15-7-8-20(17(28)11-15)39-19-9-10-29-18-13-22(38-6)21(37-5)12-16(18)19/h7-13H,14H2,1-6H3,(H,30,34)
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Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%