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Found 36 Enz. Inhib. hit(s) with all data for entry = 1715
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336803((S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((...)
Affinity DataKi:  41nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336823(6-(((2S,3R)-2-carbamoyl-3- hydroxypyrrolidin-1-yl)...)
Affinity DataKi:  46nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336819(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluo...)
Affinity DataKi:  59nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336814(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluo...)
Affinity DataKi:  80nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336815(6-((((R)-2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-...)
Affinity DataKi:  117nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336808((S)-6-(((1-amino-3-hydroxy-1- oxopropan-2-yl)amino...)
Affinity DataKi:  145nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336811(6-((((S)-1-amino-1-oxopropan- 2-yl)amino)methyl)-2...)
Affinity DataKi:  175nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336807((S)-6-(((1-amino-3-methyl-1- oxobutan-2-yl)amino)m...)
Affinity DataKi:  220nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336809(6-(((2S, 4R)-2-carbamoyl-4- hydroxypyrrolidin-1-yl...)
Affinity DataKi:  342nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336813(6-((((S)-1-amino-3-hydroxy-1- oxopropan-2-yl)amino...)
Affinity DataKi:  524nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336810((S)-6-(((2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-...)
Affinity DataKi:  662nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336817((S)-4-((6-(1,2-dihydroxyethyl)- 2-(4-(4-(trifluoro...)
Affinity DataKi:  875nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336744((S)-2-(4-((5-cyclopropylpyridin- 2-yl)oxy)phenyl)-...)
Affinity DataKi:  1.41E+3nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336816((S)-3-(((6-((S)-1,2- dihydroxyethyl)-2-(4-(4- (tri...)
Affinity DataKi:  2.68E+3nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336806((S)-6-(((1-amino-1-oxopropan- 2-yl)amino)methyl)-2...)
Affinity DataIC50:  42nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336803((S)-2-(4-(4-chloro-2-fluoro- phenoxy)phenyl)-6-(((...)
Affinity DataIC50:  65nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336819(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluo...)
Affinity DataIC50:  70nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336814(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluo...)
Affinity DataIC50:  72nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336804((S)-6-((2-carbamoylpyrrolidin- 1-yl)methyl)-2-(4-(...)
Affinity DataIC50:  85nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336823(6-(((2S,3R)-2-carbamoyl-3- hydroxypyrrolidin-1-yl)...)
Affinity DataIC50:  94nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336808((S)-6-(((1-amino-3-hydroxy-1- oxopropan-2-yl)amino...)
Affinity DataIC50:  200nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336807((S)-6-(((1-amino-3-methyl-1- oxobutan-2-yl)amino)m...)
Affinity DataIC50:  200nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336822(6-((3,5-dioxopiperazin-1- yl)methyl)-2-(4-(4-(trif...)
Affinity DataIC50:  205nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336812(6-(hydroxymethyl)-2-(4-(4- (trifluoromethyl)phenox...)
Affinity DataIC50:  242nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336805((S)-6-(((2-oxopyrrolidin- 3-yl)amino)methyl)-2-(4-...)
Affinity DataIC50:  439nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336815(6-((((R)-2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-...)
Affinity DataIC50:  544nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336811(6-((((S)-1-amino-1-oxopropan- 2-yl)amino)methyl)-2...)
Affinity DataIC50:  557nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336809(6-(((2S, 4R)-2-carbamoyl-4- hydroxypyrrolidin-1-yl...)
Affinity DataIC50:  583nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336821(6-((2,2-dimethyl-3- oxopiperazin-1-yl)methyl)-2-(4...)
Affinity DataIC50:  627nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336817((S)-4-((6-(1,2-dihydroxyethyl)- 2-(4-(4-(trifluoro...)
Affinity DataIC50:  1.19E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336813(6-((((S)-1-amino-3-hydroxy-1- oxopropan-2-yl)amino...)
Affinity DataIC50:  1.47E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336816((S)-3-(((6-((S)-1,2- dihydroxyethyl)-2-(4-(4- (tri...)
Affinity DataIC50:  1.56E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336810((S)-6-(((2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-...)
Affinity DataIC50:  1.75E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336818(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-((5-(triflu...)
Affinity DataIC50:  2.45E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336744((S)-2-(4-((5-cyclopropylpyridin- 2-yl)oxy)phenyl)-...)
Affinity DataIC50:  3.39E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336820(6-((2,2-dimethyl-3- oxopiperazin-1-yl)methyl)-2-(4...)
Affinity DataIC50: >2.00E+4nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent