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Patent code US9745310

Compile Data Set for Download or QSAR
Found 199 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292168
PNG
(US10100057, Example 23 | US9745310, Example 23)
Show SMILES COc1cc(ccc1-c1cnc2nc(COc3ccccc3)cn2c1)C#N
Show InChI InChI=1S/C21H16N4O2/c1-26-20-9-15(10-22)7-8-19(20)16-11-23-21-24-17(13-25(21)12-16)14-27-18-5-3-2-4-6-18/h2-9,11-13H,14H2,1H3
PDB
MMDB

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UniProtKB/SwissProt

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292170
PNG
(US10100057, Example 25 | US9745310, Example 25)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H16FN3O2/c21-16-6-7-19(14(8-16)12-25)15-9-22-20-23-17(11-24(20)10-15)13-26-18-4-2-1-3-5-18/h1-11,25H,12-13H2
PDB
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292177
PNG
(US10100057, Example 32 | US9745310, Example 32)
Show SMILES Cc1ccncc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H16N4O/c1-14-7-8-20-10-18(14)15-9-21-19-22-16(12-23(19)11-15)13-24-17-5-3-2-4-6-17/h2-12H,13H2,1H3
PDB
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292181
PNG
(US10100057, Example 36 | US9745310, Example 36)
Show SMILES Clc1cnccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H13ClN4O/c19-17-9-20-7-6-16(17)13-8-21-18-22-14(11-23(18)10-13)12-24-15-4-2-1-3-5-15/h1-11H,12H2
PDB
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292183
PNG
(US10100057, Example 38 | US9745310, Example 38)
Show SMILES Cc1cc(F)ncc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-7-18(20)21-9-17(13)14-8-22-19-23-15(11-24(19)10-14)12-25-16-5-3-2-4-6-16/h2-11H,12H2,1H3
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292187
PNG
(US10100057, Example 42 | US9745310, Example 42)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C20H15F2N3O2/c1-26-19-8-15(22)5-6-18(19)13-9-23-20-24-16(11-25(20)10-13)12-27-17-4-2-3-14(21)7-17/h2-11H,12H2,1H3
PDB
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292191
PNG
(US10100057, Example 46 | US9745310, Example 46)
Show SMILES Cc1ccncc1-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-5-6-21-9-18(13)14-8-22-19-23-16(11-24(19)10-14)12-25-17-4-2-3-15(20)7-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292197
PNG
(US10100057, Example 52 | US9745310, Example 52)
Show SMILES Oc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H14FN3O2/c20-15-3-1-13(2-4-15)14-9-21-19-22-16(11-23(19)10-14)12-25-18-7-5-17(24)6-8-18/h1-11,24H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292229
PNG
(US10100057, Example 84 | US9745310, Example 84)
Show SMILES COc1ccc(cc1N)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H17FN4O2/c1-26-19-7-2-13(8-18(19)22)14-9-23-20-24-16(11-25(20)10-14)12-27-17-5-3-15(21)4-6-17/h2-11H,12,22H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292249
PNG
(US10100057, Example 104 | US9745310, Example 104)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-17-8-14(20)5-6-16(17)13-9-22-19-23-15(11-24(19)10-13)12-26-18-4-2-3-7-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292251
PNG
(US10100057, Example 106 | US9745310, Example 106)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-8-15(20)5-6-17(13)14-9-22-19-23-16(11-24(19)10-14)12-25-18-4-2-3-7-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292252
PNG
(US10100057, Example 107 | US9745310, Example 107)
Show SMILES Fc1cccc(c1F)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-15-5-3-4-14(17(15)20)12-8-22-18-23-13(10-24(18)9-12)11-25-16-6-1-2-7-21-16/h1-10H,11H2
PDB
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292276
PNG
(US10100057, Example 131 | US9745310, Example 131)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(nc2)C(F)(F)F)nc1
Show InChI InChI=1S/C18H11F4N5O/c19-13-2-4-16(24-7-13)28-10-14-9-27-8-12(6-25-17(27)26-14)11-1-3-15(23-5-11)18(20,21)22/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292280
PNG
(US10100057, Example 135 | US9745310, Example 135)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c20-15-4-5-17(13(7-15)11-25)14-8-22-19-23-16(10-24(19)9-14)12-26-18-3-1-2-6-21-18/h1-10,25H,11-12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292281
PNG
(US10100057, Example 136 | US9745310, Example 136)
Show SMILES COc1cc(ccc1-c1cnc2nc(COc3ccccn3)cn2c1)C#N
Show InChI InChI=1S/C20H15N5O2/c1-26-18-8-14(9-21)5-6-17(18)15-10-23-20-24-16(12-25(20)11-15)13-27-19-4-2-3-7-22-19/h2-8,10-12H,13H2,1H3
PDB
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292282
PNG
(US10100057, Example 137 | US9745310, Example 137)
Show SMILES COc1cc(ccc1-c1cnc2nc(COc3ccc(F)cn3)cn2c1)C#N
Show InChI InChI=1S/C20H14FN5O2/c1-27-18-6-13(7-22)2-4-17(18)14-8-24-20-25-16(11-26(20)10-14)12-28-19-5-3-15(21)9-23-19/h2-6,8-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292304
PNG
(US10100057, Example 159 | US9745310, Example 159)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3cccnc3F)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-7-14(20)4-5-16(12)13-8-23-19-24-15(10-25(19)9-13)11-26-17-3-2-6-22-18(17)21/h2-10H,11H2,1H3
PDB
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292325
PNG
(US10100057, Example 180 | US9745310, Example 180)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C17H11F2N5O/c18-11-4-5-13(14(19)7-11)15-8-21-17-22-12(9-24(17)23-15)10-25-16-3-1-2-6-20-16/h1-9H,10H2
PDB
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292328
PNG
(US10100057, Example 183 | US9745310, Example 183)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccnc(F)c3)cn2n1
Show InChI InChI=1S/C17H10F3N5O/c18-10-1-2-13(14(19)5-10)15-7-22-17-23-11(8-25(17)24-15)9-26-12-3-4-21-16(20)6-12/h1-8H,9H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292329
PNG
(US10100057, Example 184 | US9745310, Example 184)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2n1
Show InChI InChI=1S/C18H13F2N5O/c1-11-6-12(19)2-3-15(11)16-8-22-18-23-13(9-25(18)24-16)10-26-14-4-5-21-17(20)7-14/h2-9H,10H2,1H3
PDB
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292331
PNG
(US10100057, Example 186 | US9745310, Example 186)
Show SMILES Fc1ccc(-c2cnc3nc(COc4ccccn4)cn3n2)c(c1)C(F)(F)F
Show InChI InChI=1S/C18H11F4N5O/c19-11-4-5-13(14(7-11)18(20,21)22)15-8-24-17-25-12(9-27(17)26-15)10-28-16-3-1-2-6-23-16/h1-9H,10H2
PDB
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292333
PNG
(US10100057, Example 188 | US9745310, Example 188)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C18H14FN5O/c1-12-8-13(19)5-6-15(12)16-9-21-18-22-14(10-24(18)23-16)11-25-17-4-2-3-7-20-17/h2-10H,11H2,1H3
PDB
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292146
PNG
(US10100057, Example 1 | US9745310, Example 1)
Show SMILES Fc1ccccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H14FN3O/c20-18-9-5-4-8-17(18)14-10-21-19-22-15(12-23(19)11-14)13-24-16-6-2-1-3-7-16/h1-12H,13H2
PDB
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292158
PNG
(US10100057, Example 13 | US9745310, Example 13)
Show SMILES Fc1ccc(cc1Cl)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H13ClFN3O/c20-17-8-13(6-7-18(17)21)14-9-22-19-23-15(11-24(19)10-14)12-25-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292167
PNG
(US10100057, Example 22 | US9745310, Example 22)
Show SMILES COc1cc(Cl)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H16ClN3O2/c1-25-19-9-15(21)7-8-18(19)14-10-22-20-23-16(12-24(20)11-14)13-26-17-5-3-2-4-6-17/h2-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292185
PNG
(US10100057, Example 40 | US9745310, Example 40)
Show SMILES Fc1ccc(nc1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H13FN4O/c19-14-6-7-17(20-9-14)13-8-21-18-22-15(11-23(18)10-13)12-24-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292212
PNG
(US10100057, Example 67 | US9745310, Example 67)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2Cl)cc1
Show InChI InChI=1S/C19H12ClF2N3O/c20-18-7-14(22)3-6-17(18)12-8-23-19-24-15(10-25(19)9-12)11-26-16-4-1-13(21)2-5-16/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292213
PNG
(US10100057, Example 68 | US9745310, Example 68)
Show SMILES COc1cc(ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1)C#N
Show InChI InChI=1S/C21H15FN4O2/c1-27-20-8-14(9-23)2-7-19(20)15-10-24-21-25-17(12-26(21)11-15)13-28-18-5-3-16(22)4-6-18/h2-8,10-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292220
PNG
(US10100057, Example 75 | US9745310, Example 75)
Show SMILES Nc1cc(Cl)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H14ClFN4O/c20-13-1-6-17(18(22)7-13)12-8-23-19-24-15(10-25(19)9-12)11-26-16-4-2-14(21)3-5-16/h1-10H,11,22H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292226
PNG
(US10100057, Example 81 | US9745310, Example 81)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccc(F)nc2)c1
Show InChI InChI=1S/C18H12F2N4O/c19-14-2-1-3-16(6-14)25-11-15-10-24-9-13(8-22-18(24)23-15)12-4-5-17(20)21-7-12/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292230
PNG
(US10100057, Example 85 | US9745310, Example 85)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cn2)cc1
Show InChI InChI=1S/C18H12F2N4O/c19-13-1-4-16(5-2-13)25-11-15-10-24-9-12(7-22-18(24)23-15)17-6-3-14(20)8-21-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292231
PNG
(US10100057, Example 86 | US9745310, Example 86)
Show SMILES COc1ccc(nc1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-17-6-7-18(21-9-17)13-8-22-19-23-15(11-24(19)10-13)12-26-16-4-2-14(20)3-5-16/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292239
PNG
(US10100057, Example 94 | US9745310, Example 94)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2C(F)(F)F)c1
Show InChI InChI=1S/C20H12F5N3O/c21-13-2-1-3-16(6-13)29-11-15-10-28-9-12(8-26-19(28)27-15)17-5-4-14(22)7-18(17)20(23,24)25/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292241
PNG
(US10100057, Example 96 | US9745310, Example 96)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C20H15F2N3O2/c21-15-2-1-3-18(7-15)27-12-17-10-25-9-14(8-23-20(25)24-17)19-5-4-16(22)6-13(19)11-26/h1-10,26H,11-12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292248
PNG
(US10100057, Example 103 | US9745310, Example 103)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H16N4O/c1-14-6-2-3-7-17(14)15-10-21-19-22-16(12-23(19)11-15)13-24-18-8-4-5-9-20-18/h2-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292253
PNG
(US10100057, Example 108 | US9745310, Example 108)
Show SMILES Cc1ccc(F)cc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-5-6-15(20)8-17(13)14-9-22-19-23-16(11-24(19)10-14)12-25-18-4-2-3-7-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292260
PNG
(US10100057, Example 115 | US9745310, Example 115)
Show SMILES CCc1ccccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C20H18N4O/c1-2-15-7-3-4-8-18(15)16-11-22-20-23-17(13-24(20)12-16)14-25-19-9-5-6-10-21-19/h3-13H,2,14H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292264
PNG
(US10100057, Example 119 | US9745310, Example 119)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2C(F)(F)F)nc1
Show InChI InChI=1S/C19H11F5N4O/c20-12-1-3-15(16(5-12)19(22,23)24)11-6-26-18-27-14(9-28(18)8-11)10-29-17-4-2-13(21)7-25-17/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292271
PNG
(US10100057, Example 126 | US9745310, Example 126)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-4-2-3-5-17(13)14-8-22-19-23-16(11-24(19)10-14)12-25-18-7-6-15(20)9-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292283
PNG
(US10100057, Example 138 | US9745310, Example 138)
Show SMILES CSc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4OS/c1-26-17-8-14(20)5-6-16(17)13-9-22-19-23-15(11-24(19)10-13)12-25-18-4-2-3-7-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292295
PNG
(US10100057, Example 150 | US9745310, Example 150)
Show SMILES Oc1cc(F)ccc1-c1cnc2nc(COc3cccnc3)cn2c1
Show InChI InChI=1S/C18H13FN4O2/c19-13-3-4-16(17(24)6-13)12-7-21-18-22-14(10-23(18)9-12)11-25-15-2-1-5-20-8-15/h1-10,24H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292296
PNG
(US10100057, Example 151 | US9745310, Example 151)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3ccncc3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-18-8-14(20)2-3-17(18)13-9-22-19-23-15(11-24(19)10-13)12-26-16-4-6-21-7-5-16/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292299
PNG
(US10100057, Example 154 | US9745310, Example 154)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-4-14(20)2-3-18(12)13-6-23-19-24-16(10-25(19)9-13)11-26-17-5-15(21)7-22-8-17/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292301
PNG
(US10100057, Example 156 | US9745310, Example 156)
Show SMILES Oc1cc(F)ccc1-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C18H12F2N4O2/c19-12-1-2-16(17(25)4-12)11-5-22-18-23-14(9-24(18)8-11)10-26-15-3-13(20)6-21-7-15/h1-9,25H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292309
PNG
(US10100057, Example 164 | US9745310, Example 164)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-14-3-1-12(2-4-14)13-8-22-18-23-15(10-24(18)9-13)11-25-16-5-6-21-17(20)7-16/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292323
PNG
(US10100057, Example 178 | US9745310, Example 178)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccccc3)cn2n1
Show InChI InChI=1S/C18H12F2N4O/c19-12-6-7-15(16(20)8-12)17-9-21-18-22-13(10-24(18)23-17)11-25-14-4-2-1-3-5-14/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292343
PNG
(US10100057, Example 198 | US9745310, Example 198)
Show SMILES FCc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c20-8-13-7-15(21)4-5-17(13)14-9-23-19-24-16(11-25(19)10-14)12-26-18-3-1-2-6-22-18/h1-7,9-11H,8,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292152
PNG
(US10100057, Example 7 | US9745310, Example 7)
Show SMILES Fc1cccc(c1F)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H13F2N3O/c20-17-8-4-7-16(18(17)21)13-9-22-19-23-14(11-24(19)10-13)12-25-15-5-2-1-3-6-15/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292172
PNG
(US10100057, Example 27 | US9745310, Example 27)
Show SMILES Nc1cc(F)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c20-14-6-7-17(18(21)8-14)13-9-22-19-23-15(11-24(19)10-13)12-25-16-4-2-1-3-5-16/h1-11H,12,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292182
PNG
(US10100057, Example 37 | US9745310, Example 37)
Show SMILES Clc1ccc(cc1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H14ClN3O/c20-16-8-6-14(7-9-16)15-10-21-19-22-17(12-23(19)11-15)13-24-18-4-2-1-3-5-18/h1-12H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292200
PNG
(US10100057, Example 55 | US9745310, Example 55)
Show SMILES Oc1cc(ccc1F)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H13F2N3O2/c20-14-2-4-16(5-3-14)26-11-15-10-24-9-13(8-22-19(24)23-15)12-1-6-17(21)18(25)7-12/h1-10,25H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292235
PNG
(US10100057, Example 90 | US9745310, Example 90)
Show SMILES Oc1ccc(cn1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C18H13FN4O2/c19-14-2-4-16(5-3-14)25-11-15-10-23-9-13(8-21-18(23)22-15)12-1-6-17(24)20-7-12/h1-10H,11H2,(H,20,24)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292242
PNG
(US10100057, Example 97 | US9745310, Example 97)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H15F2N3O2/c21-15-1-4-18(5-2-15)27-12-17-10-25-9-14(8-23-20(25)24-17)19-6-3-16(22)7-13(19)11-26/h1-10,26H,11-12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292266
PNG
(US10100057, Example 121 | US9745310, Example 121)
Show SMILES COc1c(F)cccc1-c1cnc2nc(COc3cc(F)ccn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c1-26-18-15(3-2-4-16(18)21)12-8-23-19-24-14(10-25(19)9-12)11-27-17-7-13(20)5-6-22-17/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292267
PNG
(US10100057, Example 122 | US9745310, Example 122)
Show SMILES Fc1ccnc(OCc2cn3cc(cnc3n2)-c2cccc(F)c2F)c1
Show InChI InChI=1S/C18H11F3N4O/c19-12-4-5-22-16(6-12)26-10-13-9-25-8-11(7-23-18(25)24-13)14-2-1-3-15(20)17(14)21/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292269
PNG
(US10100057, Example 124 | US9745310, Example 124)
Show SMILES Cc1c(F)cccc1-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-16(3-2-4-17(12)21)13-7-23-19-24-15(10-25(19)9-13)11-26-18-6-5-14(20)8-22-18/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292270
PNG
(US10100057, Example 125 | US9745310, Example 125)
Show SMILES Fc1ccnc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2C(F)(F)F)c1
Show InChI InChI=1S/C19H11F5N4O/c20-12-1-2-15(16(5-12)19(22,23)24)11-7-26-18-27-14(9-28(18)8-11)10-29-17-6-13(21)3-4-25-17/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292273
PNG
(US10100057, Example 128 | US9745310, Example 128)
Show SMILES Cc1ccc(c(C)c1)-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C20H17FN4O/c1-13-3-5-18(14(2)7-13)15-8-23-20-24-17(11-25(20)10-15)12-26-19-6-4-16(21)9-22-19/h3-11H,12H2,1-2H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292294
PNG
(US10100057, Example 149 | US9745310, Example 149)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3cccnc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-7-15(20)4-5-18(13)14-8-22-19-23-16(11-24(19)10-14)12-25-17-3-2-6-21-9-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292300
PNG
(US10100057, Example 155 | US9745310, Example 155)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c1-26-18-5-13(20)2-3-17(18)12-6-23-19-24-15(10-25(19)9-12)11-27-16-4-14(21)7-22-8-16/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292303
PNG
(US10100057, Example 158 | US9745310, Example 158)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)nc3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-6-14(20)2-4-17(12)13-7-23-19-24-15(10-25(19)9-13)11-26-16-3-5-18(21)22-8-16/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292338
PNG
(US10100057, Example 193 | US9745310, Example 193)
Show SMILES NC(=O)OCc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C21H16F2N4O3/c22-15-1-4-18(5-2-15)29-12-17-10-27-9-14(8-25-21(27)26-17)19-6-3-16(23)7-13(19)11-30-20(24)28/h1-10H,11-12H2,(H2,24,28)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292341
PNG
(US10100057, Example 196 | US9745310, Example 196)
Show SMILES CC(=O)OCc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C21H17FN4O3/c1-14(27)28-12-15-8-17(22)5-6-19(15)16-9-24-21-25-18(11-26(21)10-16)13-29-20-4-2-3-7-23-20/h2-11H,12-13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292344
PNG
(US10100057, Example 199 | US9745310, Example 199)
Show SMILES FCc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H14F3N3O/c21-8-13-7-16(23)3-6-19(13)14-9-24-20-25-17(11-26(20)10-14)12-27-18-4-1-15(22)2-5-18/h1-7,9-11H,8,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292148
PNG
(US10100057, Example 3 | US9745310, Example 3)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H13F2N3O/c20-14-6-7-17(18(21)8-14)13-9-22-19-23-15(11-24(19)10-13)12-25-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292149
PNG
(US10100057, Example 4 | US9745310, Example 4)
Show SMILES COc1ccccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H17N3O2/c1-24-19-10-6-5-9-18(19)15-11-21-20-22-16(13-23(20)12-15)14-25-17-7-3-2-4-8-17/h2-13H,14H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292151
PNG
(US10100057, Example 6 | US9745310, Example 6)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H16FN3O/c1-14-9-16(21)7-8-19(14)15-10-22-20-23-17(12-24(20)11-15)13-25-18-5-3-2-4-6-18/h2-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292161
PNG
(US10100057, Example 16 | US9745310, Example 16)
Show SMILES Oc1ccccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H15N3O2/c23-18-9-5-4-8-17(18)14-10-20-19-21-15(12-22(19)11-14)13-24-16-6-2-1-3-7-16/h1-12,23H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292163
PNG
(US10100057, Example 18 | US9745310, Example 18)
Show SMILES Fc1ccc(-c2cnc3nc(COc4ccccc4)cn3c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H13F4N3O/c21-14-6-7-17(18(8-14)20(22,23)24)13-9-25-19-26-15(11-27(19)10-13)12-28-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292165
PNG
(US10100057, Example 20 | US9745310, Example 20)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H16FN3O2/c1-25-19-9-15(21)7-8-18(19)14-10-22-20-23-16(12-24(20)11-14)13-26-17-5-3-2-4-6-17/h2-12H,13H2,1H3
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292166
PNG
(US10100057, Example 21 | US9745310, Example 21)
Show SMILES COc1cc(ccc1F)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H16FN3O2/c1-25-19-9-14(7-8-18(19)21)15-10-22-20-23-16(12-24(20)11-15)13-26-17-5-3-2-4-6-17/h2-12H,13H2,1H3
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292173
PNG
(US10100057, Example 28 | US9745310, Example 28)
Show SMILES COc1cc(c(F)cc1F)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H15F2N3O2/c1-26-19-7-16(17(21)8-18(19)22)13-9-23-20-24-14(11-25(20)10-13)12-27-15-5-3-2-4-6-15/h2-11H,12H2,1H3
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292180
PNG
(US10100057, Example 35 | US9745310, Example 35)
Show SMILES Fc1cc(ccn1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H13FN4O/c19-17-8-13(6-7-20-17)14-9-21-18-22-15(11-23(18)10-14)12-24-16-4-2-1-3-5-16/h1-11H,12H2
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292192
PNG
(US10100057, Example 47 | US9745310, Example 47)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C19H12F3N3O/c20-13-1-4-16(5-2-13)26-11-15-10-25-9-12(8-23-19(25)24-15)17-6-3-14(21)7-18(17)22/h1-10H,11H2
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292203
PNG
(US10100057, Example 58 | US9745310, Example 58)
Show SMILES Oc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H13F2N3O2/c20-13-1-4-16(5-2-13)26-11-15-10-24-9-12(8-22-19(24)23-15)17-6-3-14(21)7-18(17)25/h1-10,25H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292206
PNG
(US10100057, Example 61 | US9745310, Example 61)
Show SMILES Cc1ccc(F)cc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H15F2N3O/c1-13-2-3-16(22)8-19(13)14-9-23-20-24-17(11-25(20)10-14)12-26-18-6-4-15(21)5-7-18/h2-11H,12H2,1H3
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292209
PNG
(US10100057, Example 64 | US9745310, Example 64)
Show SMILES Cc1ccc(c(F)c1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H15F2N3O/c1-13-2-7-18(19(22)8-13)14-9-23-20-24-16(11-25(20)10-14)12-26-17-5-3-15(21)4-6-17/h2-11H,12H2,1H3
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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292210
PNG
(US10100057, Example 65 | US9745310, Example 65)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(nc2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N4O/c20-14-2-4-16(5-3-14)28-11-15-10-27-9-13(8-25-18(27)26-15)12-1-6-17(24-7-12)19(21,22)23/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292211
PNG
(US10100057, Example 66 | US9745310, Example 66)
Show SMILES Nc1ccccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c20-14-5-7-16(8-6-14)25-12-15-11-24-10-13(9-22-19(24)23-15)17-3-1-2-4-18(17)21/h1-11H,12,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292216
PNG
(US10100057, Example 71 | US9745310, Example 71)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccc(F)nc2F)c1
Show InChI InChI=1S/C18H11F3N4O/c19-12-2-1-3-14(6-12)26-10-13-9-25-8-11(7-22-18(25)23-13)15-4-5-16(20)24-17(15)21/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292222
PNG
(US10100057, Example 77 | US9745310, Example 77)
Show SMILES Nc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c20-13-1-4-16(5-2-13)26-11-15-10-25-9-12(8-23-19(25)24-15)17-6-3-14(21)7-18(17)22/h1-10H,11,22H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292225
PNG
(US10100057, Example 80 | US9745310, Example 80)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C19H12F4N4O/c20-14-2-1-3-16(6-14)28-11-15-10-27-9-13(8-25-18(27)26-15)12-4-5-17(24-7-12)19(21,22)23/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292228
PNG
(US10100057, Example 83 | US9745310, Example 83)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2cnc(F)c(F)c2)cc1
Show InChI InChI=1S/C18H11F3N4O/c19-13-1-3-15(4-2-13)26-10-14-9-25-8-12(7-23-18(25)24-14)11-5-16(20)17(21)22-6-11/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292232
PNG
(US10100057, Example 87 | US9745310, Example 87)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2cnccc2Cl)cc1
Show InChI InChI=1S/C18H12ClFN4O/c19-17-5-6-21-8-16(17)12-7-22-18-23-14(10-24(18)9-12)11-25-15-3-1-13(20)2-4-15/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292238
PNG
(US10100057, Example 93 | US9745310, Example 93)
Show SMILES Fc1ccc(nc1)-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-13-2-1-3-16(6-13)25-11-15-10-24-9-12(7-22-18(24)23-15)17-5-4-14(20)8-21-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292246
PNG
(US10100057, Example 101 | US9745310, Example 101)
Show SMILES Nc1cc(F)ccc1-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c20-13-2-1-3-16(6-13)26-11-15-10-25-9-12(8-23-19(25)24-15)17-5-4-14(21)7-18(17)22/h1-10H,11,22H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292256
PNG
(US10100057, Example 111 | US9745310, Example 111)
Show SMILES COc1cc(Cl)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15ClN4O2/c1-25-17-8-14(20)5-6-16(17)13-9-22-19-23-15(11-24(19)10-13)12-26-18-4-2-3-7-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292286
PNG
(US10100057, Example 141 | US9745310, Example 141)
Show SMILES COCc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C20H17FN4O2/c1-26-12-14-8-16(21)5-6-18(14)15-9-23-20-24-17(11-25(20)10-15)13-27-19-4-2-3-7-22-19/h2-11H,12-13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292291
PNG
(US10100057, Example 146 | US9745310, Example 146)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3cccnc3)cn2c1
Show InChI InChI=1S/C18H13FN4O/c19-15-5-3-13(4-6-15)14-8-21-18-22-16(11-23(18)10-14)12-24-17-2-1-7-20-9-17/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292292
PNG
(US10100057, Example 147 | US9745310, Example 147)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3cccnc3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-18-7-14(20)4-5-17(18)13-8-22-19-23-15(11-24(19)10-13)12-26-16-3-2-6-21-9-16/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292293
PNG
(US10100057, Example 148 | US9745310, Example 148)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3cccnc3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-13-3-4-16(17(20)6-13)12-7-22-18-23-14(10-24(18)9-12)11-25-15-2-1-5-21-8-15/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292297
PNG
(US10100057, Example 152 | US9745310, Example 152)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccncc3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-13-1-2-16(17(20)7-13)12-8-22-18-23-14(10-24(18)9-12)11-25-15-3-5-21-6-4-15/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292302
PNG
(US10100057, Example 157 | US9745310, Example 157)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccc(F)nc3)cn2c1
Show InChI InChI=1S/C18H11F3N4O/c19-12-1-3-15(16(20)5-12)11-6-23-18-24-13(9-25(18)8-11)10-26-14-2-4-17(21)22-7-14/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292326
PNG
(US10100057, Example 181 | US9745310, Example 181)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C17H12FN5O/c18-13-6-4-12(5-7-13)15-9-20-17-21-14(10-23(17)22-15)11-24-16-3-1-2-8-19-16/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292327
PNG
(US10100057, Example 182 | US9745310, Example 182)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C18H15N5O/c1-13-6-2-3-7-15(13)16-10-20-18-21-14(11-23(18)22-16)12-24-17-8-4-5-9-19-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292335
PNG
(US10100057, Example 190 | US9745310, Example 190)
Show SMILES Cc1cc(Cl)ccc1-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C18H14ClN5O/c1-12-8-13(19)5-6-15(12)16-9-21-18-22-14(10-24(18)23-16)11-25-17-4-2-3-7-20-17/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292162
PNG
(US10100057, Example 17 | US9745310, Example 17)
Show SMILES Oc1cccc(c1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H15N3O2/c23-17-6-4-5-14(9-17)15-10-20-19-21-16(12-22(19)11-15)13-24-18-7-2-1-3-8-18/h1-12,23H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292169
PNG
(US10100057, Example 24 | US9745310, Example 24)
Show SMILES Fc1ccc(c2OCOc12)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H14FN3O3/c21-17-7-6-16(18-19(17)27-12-26-18)13-8-22-20-23-14(10-24(20)9-13)11-25-15-4-2-1-3-5-15/h1-10H,11-12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292179
PNG
(US10100057, Example 34 | US9745310, Example 34)
Show SMILES Clc1ccc(cn1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H13ClN4O/c19-17-7-6-13(8-20-17)14-9-21-18-22-15(11-23(18)10-14)12-24-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292186
PNG
(US10100057, Example 41 | US9745310, Example 41)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2F)c1
Show InChI InChI=1S/C19H12F3N3O/c20-13-2-1-3-16(6-13)26-11-15-10-25-9-12(8-23-19(25)24-15)17-5-4-14(21)7-18(17)22/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292188
PNG
(US10100057, Example 43 | US9745310, Example 43)
Show SMILES Oc1cc(ccc1F)-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C19H13F2N3O2/c20-14-2-1-3-16(7-14)26-11-15-10-24-9-13(8-22-19(24)23-15)12-4-5-17(21)18(25)6-12/h1-10,25H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292189
PNG
(US10100057, Example 44 | US9745310, Example 44)
Show SMILES Nc1ccccc1-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c20-14-4-3-5-16(8-14)25-12-15-11-24-10-13(9-22-19(24)23-15)17-6-1-2-7-18(17)21/h1-11H,12,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292190
PNG
(US10100057, Example 45 | US9745310, Example 45)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccncc2Cl)c1
Show InChI InChI=1S/C18H12ClFN4O/c19-17-8-21-5-4-16(17)12-7-22-18-23-14(10-24(18)9-12)11-25-15-3-1-2-13(20)6-15/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292194
PNG
(US10100057, Example 49 | US9745310, Example 49)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccncc2Cl)cc1
Show InChI InChI=1S/C18H12ClFN4O/c19-17-8-21-6-5-16(17)12-7-22-18-23-14(10-24(18)9-12)11-25-15-3-1-13(20)2-4-15/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292195
PNG
(US10100057, Example 50 | US9745310, Example 50)
Show SMILES Cc1cccc(C)c1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C21H18FN3O/c1-14-4-3-5-15(2)20(14)16-10-23-21-24-18(12-25(21)11-16)13-26-19-8-6-17(22)7-9-19/h3-12H,13H2,1-2H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292208
PNG
(US10100057, Example 63 | US9745310, Example 63)
Show SMILES Oc1ccccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H14FN3O2/c20-14-5-7-16(8-6-14)25-12-15-11-23-10-13(9-21-19(23)22-15)17-3-1-2-4-18(17)24/h1-11,24H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292219
PNG
(US10100057, Example 74 | US9745310, Example 74)
Show SMILES Cc1ccc(c(N)c1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H17FN4O/c1-13-2-7-18(19(22)8-13)14-9-23-20-24-16(11-25(20)10-14)12-26-17-5-3-15(21)4-6-17/h2-11H,12,22H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292233
PNG
(US10100057, Example 88 | US9745310, Example 88)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2cncc(Cl)c2)cc1
Show InChI InChI=1S/C18H12ClFN4O/c19-14-5-12(6-21-8-14)13-7-22-18-23-16(10-24(18)9-13)11-25-17-3-1-15(20)2-4-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292236
PNG
(US10100057, Example 91 | US9745310, Example 91)
Show SMILES Cc1cc(cnc1F)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-6-13(7-22-18(12)21)14-8-23-19-24-16(10-25(19)9-14)11-26-17-4-2-15(20)3-5-17/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292244
PNG
(US10100057, Example 99 | US9745310, Example 99)
Show SMILES COc1cc(ccn1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-18-8-13(6-7-21-18)14-9-22-19-23-16(11-24(19)10-14)12-26-17-4-2-15(20)3-5-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292250
PNG
(US10100057, Example 105 | US9745310, Example 105)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-13-4-5-15(16(20)7-13)12-8-22-18-23-14(10-24(18)9-12)11-25-17-3-1-2-6-21-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292257
PNG
(US10100057, Example 112 | US9745310, Example 112)
Show SMILES COc1c(F)cccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-18-15(5-4-6-16(18)20)13-9-22-19-23-14(11-24(19)10-13)12-26-17-7-2-3-8-21-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292258
PNG
(US10100057, Example 113 | US9745310, Example 113)
Show SMILES Fc1ccc(-c2cnc3nc(COc4ccccn4)cn3c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C19H12F4N4O/c20-13-4-5-15(16(7-13)19(21,22)23)12-8-25-18-26-14(10-27(18)9-12)11-28-17-3-1-2-6-24-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292261
PNG
(US10100057, Example 116 | US9745310, Example 116)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3cc(F)ccn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-6-14(20)2-3-17(12)13-8-23-19-24-16(10-25(19)9-13)11-26-18-7-15(21)4-5-22-18/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292262
PNG
(US10100057, Example 117 | US9745310, Example 117)
Show SMILES Cc1ccc(c(F)c1)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-5-6-16(17(20)8-13)14-9-22-19-23-15(11-24(19)10-14)12-25-18-4-2-3-7-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292263
PNG
(US10100057, Example 118 | US9745310, Example 118)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3cc(F)ccn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c1-26-17-6-13(20)2-3-16(17)12-8-23-19-24-15(10-25(19)9-12)11-27-18-7-14(21)4-5-22-18/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292278
PNG
(US10100057, Example 133 | US9745310, Example 133)
Show SMILES Nc1cc(ccc1F)-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C18H13F2N5O/c19-13-2-4-17(22-7-13)26-10-14-9-25-8-12(6-23-18(25)24-14)11-1-3-15(20)16(21)5-11/h1-9H,10,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292284
PNG
(US10100057, Example 139 | US9745310, Example 139)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c20-14-1-3-17(12(5-14)10-26)13-6-23-19-24-16(9-25(19)8-13)11-27-18-4-2-15(21)7-22-18/h1-9,26H,10-11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292288
PNG
(US10100057, Example 143 | US9745310, Example 143)
Show SMILES CC(C)c1ccccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C21H20N4O/c1-15(2)18-7-3-4-8-19(18)16-11-23-21-24-17(13-25(21)12-16)14-26-20-9-5-6-10-22-20/h3-13,15H,14H2,1-2H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292289
PNG
(US10100057, Example 144 | US9745310, Example 144)
Show SMILES FC(F)(F)c1cc(C=O)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C20H13F3N4O2/c21-20(22,23)17-7-13(11-28)4-5-16(17)14-8-25-19-26-15(10-27(19)9-14)12-29-18-3-1-2-6-24-18/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292307
PNG
(US10100057, Example 162 | US9745310, Example 162)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-6-14(20)2-3-17(12)13-8-23-19-24-15(10-25(19)9-13)11-26-16-4-5-22-18(21)7-16/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292312
PNG
(US10100057, Example 167 | US9745310, Example 167)
Show SMILES Oc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C18H12F2N4O2/c19-12-1-2-15(16(25)5-12)11-7-22-18-23-13(9-24(18)8-11)10-26-14-3-4-21-17(20)6-14/h1-9,25H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292315
PNG
(US10100057, Example 170 | US9745310, Example 170)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c20-14-1-2-17(12(5-14)10-26)13-7-23-19-24-15(9-25(19)8-13)11-27-16-3-4-22-18(21)6-16/h1-9,26H,10-11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292317
PNG
(US10100057, Example 172 | US9745310, Example 172)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccnc(Cl)c3)cn2c1
Show InChI InChI=1S/C18H12ClFN4O/c19-17-7-16(5-6-21-17)25-11-15-10-24-9-13(8-22-18(24)23-15)12-1-3-14(20)4-2-12/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292320
PNG
(US10100057, Example 175 | US9745310, Example 175)
Show SMILES Nc1cc(F)ccc1-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C18H13F2N5O/c19-12-1-2-16(17(21)4-12)11-5-23-18-24-14(9-25(18)8-11)10-26-15-3-13(20)6-22-7-15/h1-9H,10,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292324
PNG
(US10100057, Example 179 | US9745310, Example 179)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccncc3)cn2n1
Show InChI InChI=1S/C17H11F2N5O/c18-11-1-2-14(15(19)7-11)16-8-21-17-22-12(9-24(17)23-16)10-25-13-3-5-20-6-4-13/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292332
PNG
(US10100057, Example 187 | US9745310, Example 187)
Show SMILES Cc1c(F)cccc1-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C18H14FN5O/c1-12-14(5-4-6-15(12)19)16-9-21-18-22-13(10-24(18)23-16)11-25-17-7-2-3-8-20-17/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292340
PNG
(US10100057, Example 195 | US9745310, Example 195)
Show SMILES NC(=O)OCc1cc(F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C20H16FN5O3/c21-15-4-5-17(13(7-15)11-29-19(22)27)14-8-24-20-25-16(10-26(20)9-14)12-28-18-3-1-2-6-23-18/h1-10H,11-12H2,(H2,22,27)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292150
PNG
(US10100057, Example 5 | US9745310, Example 5)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H17N3O/c1-15-7-5-6-10-19(15)16-11-21-20-22-17(13-23(20)12-16)14-24-18-8-3-2-4-9-18/h2-13H,14H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292153
PNG
(US10100057, Example 59 | US10100057, Example 8 | U...)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H14FN3O/c20-16-8-6-14(7-9-16)15-10-21-19-22-17(12-23(19)11-15)13-24-18-4-2-1-3-5-18/h1-12H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292160
PNG
(US10100057, Example 15 | US9745310, Example 15)
Show SMILES Fc1ccc(c(Cl)c1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H13ClFN3O/c20-18-8-14(21)6-7-17(18)13-9-22-19-23-15(11-24(19)10-13)12-25-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292171
PNG
(US10100057, Example 26 | US9745310, Example 26)
Show SMILES CSc1cc(F)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H16FN3OS/c1-26-19-9-15(21)7-8-18(19)14-10-22-20-23-16(12-24(20)11-14)13-25-17-5-3-2-4-6-17/h2-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292174
PNG
(US10100057, Example 29 | US9745310, Example 29)
Show SMILES Fc1ncccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H13FN4O/c19-17-16(7-4-8-20-17)13-9-21-18-22-14(11-23(18)10-13)12-24-15-5-2-1-3-6-15/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292175
PNG
(US10100057, Example 30 | US9745310, Example 30)
Show SMILES COc1ccc(cn1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H16N4O2/c1-24-18-8-7-14(9-20-18)15-10-21-19-22-16(12-23(19)11-15)13-25-17-5-3-2-4-6-17/h2-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292176
PNG
(US10100057, Example 31 | US9745310, Example 31)
Show SMILES Fc1ccc(cn1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H13FN4O/c19-17-7-6-13(8-20-17)14-9-21-18-22-15(11-23(18)10-14)12-24-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292178
PNG
(US10100057, Example 33 | US9745310, Example 33)
Show SMILES Fc1ccc(c(F)n1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-16-7-6-15(17(20)23-16)12-8-21-18-22-13(10-24(18)9-12)11-25-14-4-2-1-3-5-14/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292196
PNG
(US10100057, Example 51 | US9745310, Example 51)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)nc2)cc1
Show InChI InChI=1S/C18H12F2N4O/c19-14-2-4-16(5-3-14)25-11-15-10-24-9-13(8-22-18(24)23-15)12-1-6-17(20)21-7-12/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292198
PNG
(US10100057, Example 53 | US9745310, Example 53)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H13F2N3O/c20-15-3-1-13(2-4-15)14-9-22-19-23-17(11-24(19)10-14)12-25-18-7-5-16(21)6-8-18/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292202
PNG
(US10100057, Example 57 | US9745310, Example 57)
Show SMILES Oc1cc(F)ccc1-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C19H13F2N3O2/c20-13-2-1-3-16(6-13)26-11-15-10-24-9-12(8-22-19(24)23-15)17-5-4-14(21)7-18(17)25/h1-10,25H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292205
PNG
(US10100057, Example 60 | US9745310, Example 60)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H16FN3O/c1-14-4-2-3-5-19(14)15-10-22-20-23-17(12-24(20)11-15)13-25-18-8-6-16(21)7-9-18/h2-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292207
PNG
(US10100057, Example 62 | US9745310, Example 62)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccnc(F)c2)cc1
Show InChI InChI=1S/C18H12F2N4O/c19-14-1-3-16(4-2-14)25-11-15-10-24-9-13(8-22-18(24)23-15)12-5-6-21-17(20)7-12/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292218
PNG
(US10100057, Example 73 | US9745310, Example 73)
Show SMILES Nc1cc(F)c(F)cc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H13F3N4O/c20-12-1-3-14(4-2-12)27-10-13-9-26-8-11(7-24-19(26)25-13)15-5-16(21)17(22)6-18(15)23/h1-9H,10,23H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292221
PNG
(US10100057, Example 76 | US9745310, Example 76)
Show SMILES Cc1ccc(N)c(c1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H17FN4O/c1-13-2-7-19(22)18(8-13)14-9-23-20-24-16(11-25(20)10-14)12-26-17-5-3-15(21)4-6-17/h2-11H,12,22H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292223
PNG
(US10100057, Example 78 | US9745310, Example 78)
Show SMILES Cc1ccncc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-6-7-21-9-18(13)14-8-22-19-23-16(11-24(19)10-14)12-25-17-4-2-15(20)3-5-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292224
PNG
(US10100057, Example 79 | US9745310, Example 79)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccnc(F)c2)c1
Show InChI InChI=1S/C18H12F2N4O/c19-14-2-1-3-16(7-14)25-11-15-10-24-9-13(8-22-18(24)23-15)12-4-5-21-17(20)6-12/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292240
PNG
(US10100057, Example 95 | US9745310, Example 95)
Show SMILES COc1cc(ccc1-c1cnc2nc(COc3cccc(F)c3)cn2c1)C#N
Show InChI InChI=1S/C21H15FN4O2/c1-27-20-7-14(9-23)5-6-19(20)15-10-24-21-25-17(12-26(21)11-15)13-28-18-4-2-3-16(22)8-18/h2-8,10-12H,13H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292245
PNG
(US10100057, Example 100 | US9745310, Example 100)
Show SMILES Cc1ccc(N)c(c1)-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C20H17FN4O/c1-13-5-6-19(22)18(7-13)14-9-23-20-24-16(11-25(20)10-14)12-26-17-4-2-3-15(21)8-17/h2-11H,12,22H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292254
PNG
(US10100057, Example 109 | US9745310, Example 109)
Show SMILES Cc1c(F)cccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-16(5-4-6-17(13)20)14-9-22-19-23-15(11-24(19)10-14)12-25-18-7-2-3-8-21-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292277
PNG
(US10100057, Example 132 | US9745310, Example 132)
Show SMILES Fc1ccc(nc1)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C17H12FN5O/c18-13-4-5-15(20-8-13)12-7-21-17-22-14(10-23(17)9-12)11-24-16-3-1-2-6-19-16/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292298
PNG
(US10100057, Example 153 | US9745310, Example 153)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-4-2-3-5-18(13)14-7-22-19-23-16(11-24(19)10-14)12-25-17-6-15(20)8-21-9-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292305
PNG
(US10100057, Example 160 | US9745310, Example 160)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3cncc(Cl)c3)cn2c1
Show InChI InChI=1S/C19H14ClFN4O/c1-12-4-15(21)2-3-18(12)13-6-23-19-24-16(10-25(19)9-13)11-26-17-5-14(20)7-22-8-17/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292308
PNG
(US10100057, Example 163 | US9745310, Example 163)
Show SMILES COc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c1-26-17-6-13(20)2-3-16(17)12-8-23-19-24-14(10-25(19)9-12)11-27-15-4-5-22-18(21)7-15/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292311
PNG
(US10100057, Example 166 | US9745310, Example 166)
Show SMILES Fc1cc(OCc2cn3cc(cnc3n2)-c2ccccc2F)ccn1
Show InChI InChI=1S/C18H12F2N4O/c19-16-4-2-1-3-15(16)12-8-22-18-23-13(10-24(18)9-12)11-25-14-5-6-21-17(20)7-14/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292321
PNG
(US10100057, Example 176 | US9745310, Example 176)
Show SMILES Nc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C18H13F2N5O/c19-12-1-2-15(16(21)5-12)11-7-23-18-24-13(9-25(18)8-11)10-26-14-3-4-22-17(20)6-14/h1-9H,10,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292330
PNG
(US10100057, Example 185 | US9745310, Example 185)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccnc(F)c3)cn2n1
Show InChI InChI=1S/C18H14FN5O/c1-12-4-2-3-5-15(12)16-9-21-18-22-13(10-24(18)23-16)11-25-14-6-7-20-17(19)8-14/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292147
PNG
(US10100057, Example 2 | US9745310, Example 2)
Show SMILES C(Oc1ccccc1)c1cn2cc(cnc2n1)-c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-3-7-15(8-4-1)16-11-20-19-21-17(13-22(19)12-16)14-23-18-9-5-2-6-10-18/h1-13H,14H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292154
PNG
(US10100057, Example 9 | US9745310, Example 9)
Show SMILES Nc1cccc(c1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H16N4O/c20-16-6-4-5-14(9-16)15-10-21-19-22-17(12-23(19)11-15)13-24-18-7-2-1-3-8-18/h1-12H,13,20H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292155
PNG
(US10100057, Example 10 | US9745310, Example 10)
Show SMILES Nc1ccccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H16N4O/c20-18-9-5-4-8-17(18)14-10-21-19-22-15(12-23(19)11-14)13-24-16-6-2-1-3-7-16/h1-12H,13,20H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292156
PNG
(US10100057, Example 11 | US9745310, Example 11)
Show SMILES Cc1ccc(N)cc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C20H18N4O/c1-14-7-8-16(21)9-19(14)15-10-22-20-23-17(12-24(20)11-15)13-25-18-5-3-2-4-6-18/h2-12H,13,21H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292159
PNG
(US10100057, Example 14 | US9745310, Example 14)
Show SMILES CN(C)c1ccccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C21H20N4O/c1-24(2)20-11-7-6-10-19(20)16-12-22-21-23-17(14-25(21)13-16)15-26-18-8-4-3-5-9-18/h3-14H,15H2,1-2H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292164
PNG
(US10100057, Example 19 | US9745310, Example 19)
Show SMILES Fc1ccc(cc1F)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H13F2N3O/c20-17-7-6-13(8-18(17)21)14-9-22-19-23-15(11-24(19)10-14)12-25-16-4-2-1-3-5-16/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292215
PNG
(US10100057, Example 70 | US9745310, Example 70)
Show SMILES Nc1cc(ccc1F)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c20-14-2-4-16(5-3-14)26-11-15-10-25-9-13(8-23-19(25)24-15)12-1-6-17(21)18(22)7-12/h1-10H,11,22H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292227
PNG
(US10100057, Example 82 | US9745310, Example 82)
Show SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2cccnc2F)c1
Show InChI InChI=1S/C18H12F2N4O/c19-13-3-1-4-15(7-13)25-11-14-10-24-9-12(8-22-18(24)23-14)16-5-2-6-21-17(16)20/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292234
PNG
(US10100057, Example 89 | US9745310, Example 89)
Show SMILES COc1cncc(c1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H15FN4O2/c1-25-18-6-13(7-21-9-18)14-8-22-19-23-16(11-24(19)10-14)12-26-17-4-2-15(20)3-5-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292237
PNG
(US10100057, Example 92 | US9745310, Example 92)
Show SMILES Cc1ccc(cn1)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-2-3-14(8-21-13)15-9-22-19-23-17(11-24(19)10-15)12-25-18-6-4-16(20)5-7-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292247
PNG
(US10100057, Example 102 | US9745310, Example 102)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C18H13FN4O/c19-15-6-4-13(5-7-15)14-9-21-18-22-16(11-23(18)10-14)12-24-17-3-1-2-8-20-17/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292265
PNG
(US10100057, Example 120 | US9745310, Example 120)
Show SMILES Fc1ccnc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2F)c1
Show InChI InChI=1S/C18H11F3N4O/c19-12-1-2-15(16(21)5-12)11-7-23-18-24-14(9-25(18)8-11)10-26-17-6-13(20)3-4-22-17/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292268
PNG
(US10100057, Example 123 | US9745310, Example 123)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3cc(F)ccn3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-14-3-1-12(2-4-14)13-8-22-18-23-16(10-24(18)9-13)11-25-17-7-15(20)5-6-21-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292272
PNG
(US10100057, Example 127 | US9745310, Example 127)
Show SMILES Cc1cc(Cl)ccc1-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C19H14ClFN4O/c1-12-6-14(20)2-4-17(12)13-7-23-19-24-16(10-25(19)9-13)11-26-18-5-3-15(21)8-22-18/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292275
PNG
(US10100057, Example 130 | US9745310, Example 130)
Show SMILES FC(F)(F)c1ccc(cn1)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C18H12F3N5O/c19-18(20,21)15-5-4-12(7-23-15)13-8-24-17-25-14(10-26(17)9-13)11-27-16-3-1-2-6-22-16/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292279
PNG
(US10100057, Example 134 | US9745310, Example 134)
Show SMILES Nc1cc(ccc1F)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C18H14FN5O/c19-15-5-4-12(7-16(15)20)13-8-22-18-23-14(10-24(18)9-13)11-25-17-3-1-2-6-21-17/h1-10H,11,20H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292313
PNG
(US10100057, Example 168 | US9745310, Example 168)
Show SMILES Cc1ccccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-4-2-3-5-17(13)14-9-22-19-23-15(11-24(19)10-14)12-25-16-6-7-21-18(20)8-16/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292314
PNG
(US10100057, Example 169 | US9745310, Example 169)
Show SMILES Oc1ccccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C18H13FN4O2/c19-17-7-14(5-6-20-17)25-11-13-10-23-9-12(8-21-18(23)22-13)15-3-1-2-4-16(15)24/h1-10,24H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292316
PNG
(US10100057, Example 171 | US9745310, Example 171)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-14-3-1-12(2-4-14)13-6-22-18-23-16(10-24(18)9-13)11-25-17-5-15(20)7-21-8-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292319
PNG
(US10100057, Example 174 | US9745310, Example 174)
Show SMILES Fc1ccc(-c2cnc3nc(COc4ccnc(F)c4)cn3c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C19H11F5N4O/c20-12-1-2-15(16(5-12)19(22,23)24)11-7-26-18-27-13(9-28(18)8-11)10-29-14-3-4-25-17(21)6-14/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292337
PNG
(US10100057, Example 192 | US9745310, Example 192)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cn3)cn2n1
Show InChI InChI=1S/C18H13F2N5O/c1-11-6-12(19)2-4-15(11)16-8-22-18-23-14(9-25(18)24-16)10-26-17-5-3-13(20)7-21-17/h2-9H,10H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292342
PNG
(US10100057, Example 197 | US9745310, Example 197)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccc(F)cc2CCl)cc1
Show InChI InChI=1S/C20H14ClF2N3O/c21-8-13-7-16(23)3-6-19(13)14-9-24-20-25-17(11-26(20)10-14)12-27-18-4-1-15(22)2-5-18/h1-7,9-11H,8,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292157
PNG
(US10100057, Example 12 | US9745310, Example 12)
Show SMILES Nc1cc(ccc1F)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c20-17-7-6-13(8-18(17)21)14-9-22-19-23-15(11-24(19)10-14)12-25-16-4-2-1-3-5-16/h1-11H,12,21H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292184
PNG
(US10100057, Example 39 | US9745310, Example 39)
Show SMILES Cc1cc(cnc1F)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H15FN4O/c1-13-7-14(8-21-18(13)20)15-9-22-19-23-16(11-24(19)10-15)12-25-17-5-3-2-4-6-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292193
PNG
(US10100057, Example 48 | US9745310, Example 48)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H15F2N3O/c1-13-8-16(22)4-7-19(13)14-9-23-20-24-17(11-25(20)10-14)12-26-18-5-2-15(21)3-6-18/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292199
PNG
(US10100057, Example 54 | US9745310, Example 54)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3cccc(F)c3)cn2c1
Show InChI InChI=1S/C19H13F2N3O/c20-15-6-4-13(5-7-15)14-9-22-19-23-17(11-24(19)10-14)12-25-18-3-1-2-16(21)8-18/h1-11H,12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292201
PNG
(US10100057, Example 56 | US9745310, Example 56)
Show SMILES Fc1ccc(OCc2cn3cc(cnc3n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H14FN3O/c20-16-6-8-18(9-7-16)24-13-17-12-23-11-15(10-21-19(23)22-17)14-4-2-1-3-5-14/h1-12H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292153
PNG
(US10100057, Example 59 | US10100057, Example 8 | U...)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C19H14FN3O/c20-16-8-6-14(7-9-16)15-10-21-19-22-17(12-23(19)11-15)13-24-18-4-2-1-3-5-18/h1-12H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292214
PNG
(US10100057, Example 69 | US9745310, Example 69)
Show SMILES COc1cc(Cl)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H15ClFN3O2/c1-26-19-8-14(21)2-7-18(19)13-9-23-20-24-16(11-25(20)10-13)12-27-17-5-3-15(22)4-6-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292217
PNG
(US10100057, Example 72 | US9745310, Example 72)
Show SMILES Cc1ccc(cc1N)-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H17FN4O/c1-13-2-3-14(8-19(13)22)15-9-23-20-24-17(11-25(20)10-15)12-26-18-6-4-16(21)5-7-18/h2-11H,12,22H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292243
PNG
(US10100057, Example 98 | US9745310, Example 98)
Show SMILES CSc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1
Show InChI InChI=1S/C20H15F2N3OS/c1-27-19-8-15(22)4-7-18(19)13-9-23-20-24-16(11-25(20)10-13)12-26-17-5-2-14(21)3-6-17/h2-11H,12H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292255
PNG
(US10100057, Example 110 | US9745310, Example 110)
Show SMILES Fc1ccc(c2OCOc12)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H13FN4O3/c20-15-5-4-14(17-18(15)27-11-26-17)12-7-22-19-23-13(9-24(19)8-12)10-25-16-3-1-2-6-21-16/h1-9H,10-11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292259
PNG
(US10100057, Example 114 | US9745310, Example 114)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C19H14F2N4O/c1-12-6-14(20)2-4-17(12)13-7-23-19-24-16(10-25(19)9-13)11-26-18-5-3-15(21)8-22-18/h2-10H,11H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292274
PNG
(US10100057, Example 129 | US9745310, Example 129)
Show SMILES Fc1ccc(cc1)-c1cnc2nc(COc3ccc(F)cn3)cn2c1
Show InChI InChI=1S/C18H12F2N4O/c19-14-3-1-12(2-4-14)13-7-22-18-23-16(10-24(18)9-13)11-25-17-6-5-15(20)8-21-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292285
PNG
(US10100057, Example 140 | US9745310, Example 140)
Show SMILES N#Cc1ccc(cc1)-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H13N5O/c20-9-14-4-6-15(7-5-14)16-10-22-19-23-17(12-24(19)11-16)13-25-18-3-1-2-8-21-18/h1-8,10-12H,13H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292287
PNG
(US10100057, Example 142 | US9745310, Example 142)
Show SMILES OCc1cc(ccc1-c1cnc2nc(COc3ccccn3)cn2c1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O2/c21-20(22,23)15-4-5-17(13(7-15)11-28)14-8-25-19-26-16(10-27(19)9-14)12-29-18-3-1-2-6-24-18/h1-10,28H,11-12H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292290
PNG
(US10100057, Example 145 | US9745310, Example 145)
Show SMILES FC(F)(F)c1cc(Cl)ccc1-c1cnc2nc(COc3ccccn3)cn2c1
Show InChI InChI=1S/C19H12ClF3N4O/c20-13-4-5-15(16(7-13)19(21,22)23)12-8-25-18-26-14(10-27(18)9-12)11-28-17-3-1-2-6-24-17/h1-10H,11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292306
PNG
(US10100057, Example 161 | US9745310, Example 161)
Show SMILES Fc1ccc(c(F)c1)-c1cnc2nc(COc3ccnc(F)c3)cn2c1
Show InChI InChI=1S/C18H11F3N4O/c19-12-1-2-15(16(20)5-12)11-7-23-18-24-13(9-25(18)8-11)10-26-14-3-4-22-17(21)6-14/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292310
PNG
(US10100057, Example 165 | US9745310, Example 165)
Show SMILES Fc1cc(OCc2cn3cc(cnc3n2)-c2cccc(F)c2F)ccn1
Show InChI InChI=1S/C18H11F3N4O/c19-15-3-1-2-14(17(15)21)11-7-23-18-24-12(9-25(18)8-11)10-26-13-4-5-22-16(20)6-13/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292318
PNG
(US10100057, Example 173 | US9745310, Example 173)
Show SMILES Fc1ccc(-c2cnc3nc(COc4cncc(F)c4)cn3c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C19H11F5N4O/c20-12-1-2-16(17(4-12)19(22,23)24)11-5-26-18-27-14(9-28(18)8-11)10-29-15-3-13(21)6-25-7-15/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292322
PNG
(US10100057, Example 177 | US9745310, Example 177)
Show SMILES OCc1cc(F)ccc1-c1cnc2nc(COc3cncc(F)c3)cn2c1
Show InChI InChI=1S/C19H14F2N4O2/c20-14-1-2-18(12(3-14)10-26)13-5-23-19-24-16(9-25(19)8-13)11-27-17-4-15(21)6-22-7-17/h1-9,26H,10-11H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292334
PNG
(US10100057, Example 189 | US9745310, Example 189)
Show SMILES FC(F)(F)c1cc(Cl)ccc1-c1cnc2nc(COc3ccccn3)cn2n1
Show InChI InChI=1S/C18H11ClF3N5O/c19-11-4-5-13(14(7-11)18(20,21)22)15-8-24-17-25-12(9-27(17)26-15)10-28-16-3-1-2-6-23-16/h1-9H,10H2
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292336
PNG
(US10100057, Example 191 | US9745310, Example 191)
Show SMILES Cc1cc(F)ccc1-c1cnc2nc(COc3cccc(F)n3)cn2n1
Show InChI InChI=1S/C18H13F2N5O/c1-11-7-12(19)5-6-14(11)15-8-21-18-22-13(9-25(18)24-15)10-26-17-4-2-3-16(20)23-17/h2-9H,10H2,1H3
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM292339
PNG
(US10100057, Example 194 | US9745310, Example 194)
Show SMILES NC(=O)OCc1cc(F)ccc1-c1cnc2nc(COc3ccccc3)cn2c1
Show InChI InChI=1S/C21H17FN4O3/c22-16-6-7-19(14(8-16)12-29-20(23)27)15-9-24-21-25-17(11-26(21)10-15)13-28-18-4-2-1-3-5-18/h1-11H,12-13H2,(H2,23,27)
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SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...


US Patent US9745310 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%