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Patent code US9745311

Compile Data Set for Download or QSAR

Found 266 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337265
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-ethylpipe...)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C28H33N5O2/c1-4-32-11-13-33(14-12-32)23-9-6-21(7-10-23)26-18-27-28(31-26)29-19-22(30-27)8-5-20-15-24(34-2)17-25(16-20)35-3/h6-7,9-10,15-19H,4-5,8,11-14H2,1-3H3,(H,29,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337270
PNG
(N-(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(NC(C)=O)cc2)cc(OC)c1
Show InChI InChI=1S/C24H24N4O3/c1-15(29)26-18-8-5-17(6-9-18)22-13-23-24(28-22)25-14-19(27-23)7-4-16-10-20(30-2)12-21(11-16)31-3/h5-6,8-14H,4,7H2,1-3H3,(H,25,28)(H,26,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337276
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(piperidin-1...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CN3CCCCC3)cc2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-33-24-14-21(15-25(16-24)34-2)8-11-23-18-29-28-27(30-23)17-26(31-28)22-9-6-20(7-10-22)19-32-12-4-3-5-13-32/h6-7,9-10,14-18H,3-5,8,11-13,19H2,1-2H3,(H,29,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337284
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[5-(morpholin-4...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cncc(c2)C(=O)N2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C26H27N5O4/c1-33-21-9-17(10-22(12-21)34-2)3-4-20-16-28-25-24(29-20)13-23(30-25)18-11-19(15-27-14-18)26(32)31-5-7-35-8-6-31/h9-16H,3-8H2,1-2H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337285
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(s2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C21H19N3O4S/c1-27-14-7-12(8-15(9-14)28-2)3-4-13-11-22-20-17(23-13)10-16(24-20)18-5-6-19(29-18)21(25)26/h5-11H,3-4H2,1-2H3,(H,22,24)(H,25,26)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337302
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(1H-pyrazol-4-y...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cn[nH]c2)cc(OC)c1
Show InChI InChI=1S/C19H19N5O2/c1-25-15-5-12(6-16(7-15)26-2)3-4-14-11-20-19-18(23-14)8-17(24-19)13-9-21-22-10-13/h5-11H,3-4H2,1-2H3,(H,20,24)(H,21,22)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337305
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[1-(tetrahydro-...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(c2)C2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C24H27N5O3/c1-30-20-9-16(10-21(11-20)31-2)3-4-18-14-25-24-23(27-18)12-22(28-24)17-13-26-29(15-17)19-5-7-32-8-6-19/h9-15,19H,3-8H2,1-2H3,(H,25,28)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337308
PNG
(3-cyclopentyl-3-(4-{2-[2-(3,5-dimethoxyphenyl)ethy...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(c2)C(CC#N)C2CCCC2)cc(OC)c1
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337313
PNG
(1-[2-(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrro...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(CCN3CCC(O)CC3)c2)cc(OC)c1
Show InChI InChI=1S/C26H32N6O3/c1-34-22-11-18(12-23(13-22)35-2)3-4-20-16-27-26-25(29-20)14-24(30-26)19-15-28-32(17-19)10-9-31-7-5-21(33)6-8-31/h11-17,21,33H,3-10H2,1-2H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337314
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[1-(2-piperidin...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(CCN3CCCCC3)c2)cc(OC)c1
Show InChI InChI=1S/C26H32N6O2/c1-33-22-12-19(13-23(14-22)34-2)6-7-21-17-27-26-25(29-21)15-24(30-26)20-16-28-32(18-20)11-10-31-8-4-3-5-9-31/h12-18H,3-11H2,1-2H3,(H,27,30)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337317
PNG
(2-(4-(2-(3,5-dimethoxyphenethyl)-5H-pyrrolo[2,3-b]...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(CC(=O)N3CCN(C)CC3)c2)cc(OC)c1
Show InChI InChI=1S/C26H31N7O3/c1-31-6-8-32(9-7-31)25(34)17-33-16-19(14-28-33)23-13-24-26(30-23)27-15-20(29-24)5-4-18-10-21(35-2)12-22(11-18)36-3/h10-16H,4-9,17H2,1-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337321
PNG
(2-[2-(2-chloro-3,5-dimethoxyphenyl)ethyl]-6-[4-(4-...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2)c(Cl)c(OC)c1
Show InChI InChI=1S/C27H30ClN5O2/c1-32-10-12-33(13-11-32)21-8-5-18(6-9-21)23-16-24-27(31-23)29-17-20(30-24)7-4-19-14-22(34-2)15-25(35-3)26(19)28/h5-6,8-9,14-17H,4,7,10-13H2,1-3H3,(H,29,31)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337323
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-N-methyl-6-[4-(4-...)
Show SMILES CNC(=O)c1c([nH]c2ncc(CCc3cc(OC)cc(OC)c3)nc12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C29H34N6O3/c1-30-29(36)25-26(20-6-9-22(10-7-20)35-13-11-34(2)12-14-35)33-28-27(25)32-21(18-31-28)8-5-19-15-23(37-3)17-24(16-19)38-4/h6-7,9-10,15-18H,5,8,11-14H2,1-4H3,(H,30,36)(H,31,33)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337325
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-7-ethyl-6-[4-(4-m...)
Show SMILES CCc1c([nH]c2ncc(CCc3cc(OC)cc(OC)c3)nc12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C29H35N5O2/c1-5-26-27(21-7-10-23(11-8-21)34-14-12-33(2)13-15-34)32-29-28(26)31-22(19-30-29)9-6-20-16-24(35-3)18-25(17-20)36-4/h7-8,10-11,16-19H,5-6,9,12-15H2,1-4H3,(H,30,32)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337327
PNG
(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(F)c(c2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C25H25FN4O3/c1-30(2)25(31)20-11-16(6-8-21(20)26)22-13-23-24(29-22)27-14-17(28-23)7-5-15-9-18(32-3)12-19(10-15)33-4/h6,8-14H,5,7H2,1-4H3,(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337329
PNG
(2-Chloro-4-(2-(3,5-dimethoxyphenethyl)-5H-pyrrolo[...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(C(=O)N(C)C)c(Cl)c2)cc(OC)c1
Show InChI InChI=1S/C25H25ClN4O3/c1-30(2)25(31)20-8-6-16(11-21(20)26)22-13-23-24(29-22)27-14-17(28-23)7-5-15-9-18(32-3)12-19(10-15)33-4/h6,8-14H,5,7H2,1-4H3,(H,27,29)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337329
PNG
(2-Chloro-4-(2-(3,5-dimethoxyphenethyl)-5H-pyrrolo[...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(C(=O)N(C)C)c(Cl)c2)cc(OC)c1
Show InChI InChI=1S/C25H25ClN4O3/c1-30(2)25(31)20-8-6-16(11-21(20)26)22-13-23-24(29-22)27-14-17(28-23)7-5-15-9-18(32-3)12-19(10-15)33-4/h6,8-14H,5,7H2,1-4H3,(H,27,29)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337339
PNG
(7-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnc3nccnc3c2)cc(OC)c1
Show InChI InChI=1S/C23H20N6O2/c1-30-17-7-14(8-18(10-17)31-2)3-4-16-13-27-23-21(28-16)11-19(29-23)15-9-20-22(26-12-15)25-6-5-24-20/h5-13H,3-4H2,1-2H3,(H,27,29)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337342
PNG
(4-(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cncc(c2)N2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C25H27N5O3/c1-31-21-9-17(10-22(12-21)32-2)3-4-19-15-27-25-24(28-19)13-23(29-25)18-11-20(16-26-14-18)30-5-7-33-8-6-30/h9-16H,3-8H2,1-2H3,(H,27,29)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337346
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES CNC(=O)c1cc(ccn1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H23N5O3/c1-24-23(29)21-10-15(6-7-25-21)19-12-20-22(28-19)26-13-16(27-20)5-4-14-8-17(30-2)11-18(9-14)31-3/h6-13H,4-5H2,1-3H3,(H,24,29)(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337346
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES CNC(=O)c1cc(ccn1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H23N5O3/c1-24-23(29)21-10-15(6-7-25-21)19-12-20-22(28-19)26-13-16(27-20)5-4-14-8-17(30-2)11-18(9-14)31-3/h6-13H,4-5H2,1-3H3,(H,24,29)(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337347
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C24H25N5O3/c1-29(2)24(30)22-11-16(7-8-25-22)20-13-21-23(28-20)26-14-17(27-21)6-5-15-9-18(31-3)12-19(10-15)32-4/h7-14H,5-6H2,1-4H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337348
PNG
((4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]py...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C(=O)N2CC(O)C2)cc(OC)c1
Show InChI InChI=1S/C25H25N5O4/c1-33-19-7-15(8-20(10-19)34-2)3-4-17-12-27-24-22(28-17)11-21(29-24)16-5-6-26-23(9-16)25(32)30-13-18(31)14-30/h5-12,18,31H,3-4,13-14H2,1-2H3,(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337349
PNG
(1-(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2=O)cc(OC)c1
Show InChI InChI=1S/C27H29N5O3/c1-31-10-11-32(26(33)17-31)21-8-5-19(6-9-21)24-15-25-27(30-24)28-16-20(29-25)7-4-18-12-22(34-2)14-23(13-18)35-3/h5-6,8-9,12-16H,4,7,10-11,17H2,1-3H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337353
PNG
(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc3NC(=O)Cc3c2)cc(OC)c1
Show InChI InChI=1S/C24H22N4O3/c1-30-18-7-14(8-19(11-18)31-2)3-5-17-13-25-24-22(26-17)12-21(28-24)15-4-6-20-16(9-15)10-23(29)27-20/h4,6-9,11-13H,3,5,10H2,1-2H3,(H,25,28)(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337354
PNG
(4-(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)C(=O)C2)cc(OC)c1
Show InChI InChI=1S/C27H29N5O3/c1-31-10-11-32(17-26(31)33)21-8-5-19(6-9-21)24-15-25-27(30-24)28-16-20(29-25)7-4-18-12-22(34-2)14-23(13-18)35-3/h5-6,8-9,12-16H,4,7,10-11,17H2,1-3H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337355
PNG
(2-(2-Fluoro-3,5-dimethoxyphenethyl)-6-(4-(4-methyl...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2)c(F)c(OC)c1
Show InChI InChI=1S/C27H30FN5O2/c1-32-10-12-33(13-11-32)21-8-5-18(6-9-21)23-16-24-27(31-23)29-17-20(30-24)7-4-19-14-22(34-2)15-25(35-3)26(19)28/h5-6,8-9,14-17H,4,7,10-13H2,1-3H3,(H,29,31)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337359
PNG
(2-(2,6-difluoro-3,5-dimethoxyphenethyl)-6-(2-metho...)
Show SMILES COc1cc(OC)c(F)c(CCc2cnc3[nH]c(cc3n2)-c2cccnc2OC)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-29-17-10-18(30-2)20(24)14(19(17)23)7-6-12-11-26-21-16(27-12)9-15(28-21)13-5-4-8-25-22(13)31-3/h4-5,8-11H,6-7H2,1-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337264
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C27H31N5O2/c1-31-10-12-32(13-11-31)22-8-5-20(6-9-22)25-17-26-27(30-25)28-18-21(29-26)7-4-19-14-23(33-2)16-24(15-19)34-3/h5-6,8-9,14-18H,4,7,10-13H2,1-3H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337272
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C25H26N4O3/c1-29(2)25(30)18-8-6-17(7-9-18)22-14-23-24(28-22)26-15-19(27-23)10-5-16-11-20(31-3)13-21(12-16)32-4/h6-9,11-15H,5,10H2,1-4H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337277
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(methoxymeth...)
Show SMILES COCc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C24H25N3O3/c1-28-15-16-4-7-18(8-5-16)22-13-23-24(27-22)25-14-19(26-23)9-6-17-10-20(29-2)12-21(11-17)30-3/h4-5,7-8,10-14H,6,9,15H2,1-3H3,(H,25,27)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337290
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(1-methyl-1,2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)C2=CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C22H26N4O2/c1-26-8-6-16(7-9-26)20-13-21-22(25-20)23-14-17(24-21)5-4-15-10-18(27-2)12-19(11-15)28-3/h6,10-14H,4-5,7-9H2,1-3H3,(H,23,25)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337300
PNG
(3-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES CCN(CC)CC#Cc1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H28N4O2/c1-5-27(6-2)11-7-8-18-14-22-23(26-18)24-16-19(25-22)10-9-17-12-20(28-3)15-21(13-17)29-4/h12-16H,5-6,9-11H2,1-4H3,(H,24,26)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337308
PNG
(3-cyclopentyl-3-(4-{2-[2-(3,5-dimethoxyphenyl)ethy...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(c2)C(CC#N)C2CCCC2)cc(OC)c1
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337311
PNG
(2-(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(CCO)c2)cc(OC)c1
Show InChI InChI=1S/C21H23N5O3/c1-28-17-7-14(8-18(9-17)29-2)3-4-16-12-22-21-20(24-16)10-19(25-21)15-11-23-26(13-15)5-6-27/h7-13,27H,3-6H2,1-2H3,(H,22,25)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337315
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-{1-[2-(4-methyl...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(CCN3CCN(C)CC3)c2)cc(OC)c1
Show InChI InChI=1S/C26H33N7O2/c1-31-6-8-32(9-7-31)10-11-33-18-20(16-28-33)24-15-25-26(30-24)27-17-21(29-25)5-4-19-12-22(34-2)14-23(13-19)35-3/h12-18H,4-11H2,1-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337317
PNG
(2-(4-(2-(3,5-dimethoxyphenethyl)-5H-pyrrolo[2,3-b]...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnn(CC(=O)N3CCN(C)CC3)c2)cc(OC)c1
Show InChI InChI=1S/C26H31N7O3/c1-31-6-8-32(9-7-31)25(34)17-33-16-19(14-28-33)23-13-24-26(30-23)27-15-20(29-24)5-4-18-10-21(35-2)12-22(11-18)36-3/h10-16H,4-9,17H2,1-3H3,(H,27,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337320
PNG
(7-chloro-2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-...)
Show SMILES COc1cc(CCc2cnc3[nH]c(c(Cl)c3n2)-c2ccc(cc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C27H30ClN5O2/c1-32-10-12-33(13-11-32)21-8-5-19(6-9-21)25-24(28)26-27(31-25)29-17-20(30-26)7-4-18-14-22(34-2)16-23(15-18)35-3/h5-6,8-9,14-17H,4,7,10-13H2,1-3H3,(H,29,31)
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US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337328
PNG
(2-(3,5-Dimethoxyphenethyl)-6-(2-(4-methylpiperazin...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C26H30N6O2/c1-31-8-10-32(11-9-31)25-14-19(6-7-27-25)23-16-24-26(30-23)28-17-20(29-24)5-4-18-12-21(33-2)15-22(13-18)34-3/h6-7,12-17H,4-5,8-11H2,1-3H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337332
PNG
(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(nc2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C24H25N5O3/c1-29(2)24(30)20-8-6-16(13-25-20)21-12-22-23(28-21)26-14-17(27-22)7-5-15-9-18(31-3)11-19(10-15)32-4/h6,8-14H,5,7H2,1-4H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337332
PNG
(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(nc2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C24H25N5O3/c1-29(2)24(30)20-8-6-16(13-25-20)21-12-22-23(28-21)26-14-17(27-22)7-5-15-9-18(31-3)11-19(10-15)32-4/h6,8-14H,5,7H2,1-4H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337333
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C#N)cc(OC)c1
Show InChI InChI=1S/C22H19N5O2/c1-28-18-7-14(8-19(10-18)29-2)3-4-16-13-25-22-21(26-16)11-20(27-22)15-5-6-24-17(9-15)12-23/h5-11,13H,3-4H2,1-2H3,(H,25,27)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337334
PNG
(2-(3,5-Dimethoxyphenethyl)-6-(6-methoxypyridin-3-y...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(OC)nc2)cc(OC)c1
Show InChI InChI=1S/C22H22N4O3/c1-27-17-8-14(9-18(10-17)28-2)4-6-16-13-24-22-20(25-16)11-19(26-22)15-5-7-21(29-3)23-12-15/h5,7-13H,4,6H2,1-3H3,(H,24,26)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337334
PNG
(2-(3,5-Dimethoxyphenethyl)-6-(6-methoxypyridin-3-y...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(OC)nc2)cc(OC)c1
Show InChI InChI=1S/C22H22N4O3/c1-27-17-8-14(9-18(10-17)28-2)4-6-16-13-24-22-20(25-16)11-19(26-22)15-5-7-21(29-3)23-12-15/h5,7-13H,4,6H2,1-3H3,(H,24,26)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM337338
PNG
(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(F)c(c2)C#N)cc(OC)c1
Show InChI InChI=1S/C23H19FN4O2/c1-29-18-7-14(8-19(10-18)30-2)3-5-17-13-26-23-22(27-17)11-21(28-23)15-4-6-20(24)16(9-15)12-25/h4,6-11,13H,3,5H2,1-2H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337341
PNG
(1-(5-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(nc2)N2CCCC2=O)cc(OC)c1
Show InChI InChI=1S/C25H25N5O3/c1-32-19-10-16(11-20(12-19)33-2)5-7-18-15-27-25-22(28-18)13-21(29-25)17-6-8-23(26-14-17)30-9-3-4-24(30)31/h6,8,10-15H,3-5,7,9H2,1-2H3,(H,27,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337346
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES CNC(=O)c1cc(ccn1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H23N5O3/c1-24-23(29)21-10-15(6-7-25-21)19-12-20-22(28-19)26-13-16(27-20)5-4-14-8-17(30-2)11-18(9-14)31-3/h6-13H,4-5H2,1-3H3,(H,24,29)(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337351
PNG
(2-(3,5-Dimethoxyphenethyl)-6-(3-(piperazin-1-yl)ph...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cccc(c2)N2CCNCC2)cc(OC)c1
Show InChI InChI=1S/C26H29N5O2/c1-32-22-12-18(13-23(15-22)33-2)6-7-20-17-28-26-25(29-20)16-24(30-26)19-4-3-5-21(14-19)31-10-8-27-9-11-31/h3-5,12-17,27H,6-11H2,1-2H3,(H,28,30)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM337357
PNG
(2-(2,6-difluoro-3,5-dimethoxyphenethyl)-6-(1-methy...)
Show SMILES COc1cc(OC)c(F)c(CCc2cnc3[nH]c(cc3n2)-c2cnn(C)c2)c1F
Show InChI InChI=1S/C20H19F2N5O2/c1-27-10-11(8-24-27)14-6-15-20(26-14)23-9-12(25-15)4-5-13-18(21)16(28-2)7-17(29-3)19(13)22/h6-10H,4-5H2,1-3H3,(H,23,26)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM337359
PNG
(2-(2,6-difluoro-3,5-dimethoxyphenethyl)-6-(2-metho...)
Show SMILES COc1cc(OC)c(F)c(CCc2cnc3[nH]c(cc3n2)-c2cccnc2OC)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-29-17-10-18(30-2)20(24)14(19(17)23)7-6-12-11-26-21-16(27-12)9-15(28-21)13-5-4-8-25-22(13)31-3/h4-5,8-11H,6-7H2,1-3H3,(H,26,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...

US Patent US9745311 (2017)


BindingDB Entry DOI: 10.7270/Q2125VS5
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%