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Patent code US9750748

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337629
PNG
(6-Ethyl-4-hydroxypyridazin-3(2H)-one | US9750748, ...)
Show SMILES CCc1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337636
PNG
(4-Hydroxy-6-isopropylpyridazin-3(2H)-one | US97507...)
Show SMILES CC(C)c1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337631
PNG
(6-Cyclopropyl-4-hydroxypyridazin-3(2H)-one | US975...)
Show SMILES Oc1cc(n[nH]c1=O)C1CC1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337644
PNG
(6-tert-Butyl-4-hydroxypyridazin-3(2H)-one | US9750...)
Show SMILES CC(C)(C)c1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337638
PNG
(6-(Dimethylamino)-4-hydroxypyridazin-3(2H)-one | U...)
Show SMILES CN(C)c1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337630
PNG
(4-Hydroxy-6-(3-methylbutyl)pyridazin-3(2H)-one | U...)
Show SMILES CC(C)CCc1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337633
PNG
(4-Hydroxy-6-(2-methylpropyl)pyridazin-3(2H)-one | ...)
Show SMILES CC(C)Cc1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337642
PNG
(6-(Ethyl(methyl)amino)-4-hydroxypyridazin-3(2H)-on...)
Show SMILES CCN(C)c1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337641
PNG
(4-Hydroxy-6-(methyl(propyl)amino)pyridazin-3(2H)-o...)
Show SMILES CCCN(C)c1cc(O)c(=O)[nH]n1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337634
PNG
(6-Cyclopentyl-4-hydroxypyridazin-3(2H)-one | US975...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCC1
PDB
MMDB

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UniChem
US Patent
n/an/a 670n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337635
PNG
(6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one | BDBM50...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCCC1
PDB
MMDB

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UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337637
PNG
(6-(Azetidin-1-yl)-4-hydroxypyridazin-3(2H)-one | U...)
Show SMILES Oc1cc(n[nH]c1=O)N1CCC1
PDB
MMDB

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UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337643
PNG
(4-Hydroxy-6-(piperidin-1-yl)pyridazin-3(2H)-one | ...)
Show SMILES Oc1cc(n[nH]c1=O)N1CCCCC1
PDB
MMDB

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UniChem
US Patent
n/an/a 3.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (Human))
BDBM337632
PNG
(4-Hydroxy-6-(tetrahydro-2H-pyran-4-yl)pyridazin-3(...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCOCC1
PDB
MMDB

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UniChem
US Patent
n/an/a 4.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%