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Patent code US9751843

Compile Data Set for Download or QSAR
Found 148 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (Human))
BDBM337803
PNG
(2,4-Dioxo-1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(C2CCCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C25H20F3N3O6/c26-25(27,28)19-5-1-4-17-16(19)3-2-6-20(17)31-21(32)18(22(33)34)13-30(23(31)35)15-9-7-14(8-10-15)29-11-12-37-24(29)36/h1,4-5,7-10,13,20H,2-3,6,11-12H2,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337774
PNG
(1-[3,5-Dichloro-4-(2-oxoimidazolidin-1-yl)phenyl]-...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3cc(Cl)c(N4CCNC4=O)c(Cl)c3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H17Cl2F3N4O5/c1-11-12(3-2-4-15(11)23(26,27)28)9-32-19(33)14(20(34)35)10-31(22(32)37)13-7-16(24)18(17(25)8-13)30-6-5-29-21(30)36/h2-4,7-8,10H,5-6,9H2,1H3,(H,29,36)(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337767
PNG
(1-[3-Chloro-4-(2-oxoimidazolidin-1-yl)phenyl]-3-[2...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(N4CCNC4=O)c(Cl)c3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H18ClF3N4O5/c1-12-13(3-2-4-16(12)23(25,26)27)10-31-19(32)15(20(33)34)11-30(22(31)36)14-5-6-18(17(24)9-14)29-8-7-28-21(29)35/h2-6,9,11H,7-8,10H2,1H3,(H,28,35)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337796
PNG
(1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-2...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2F)N2CCOC2=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C24H17F4N3O6/c25-17-10-12(29-8-9-37-23(29)36)4-6-19(17)30-11-15(21(33)34)20(32)31(22(30)35)18-7-5-13-14(18)2-1-3-16(13)24(26,27)28/h1-4,6,10-11,18H,5,7-9H2,(H,33,34)/t18-/m1/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337766
PNG
(1-[3-Chloro-4-(2-oxoimidazolidin-1-yl)phenyl]-3-[2...)
Show SMILES OC(=O)c1cn(-c2ccc(N3CCNC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H15Cl2F3N4O5/c23-15-8-12(4-5-16(15)29-7-6-28-20(29)35)30-10-13(19(33)34)18(32)31(21(30)36)9-11-2-1-3-14(17(11)24)22(25,26)27/h1-5,8,10H,6-7,9H2,(H,28,35)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337759
PNG
(1-[3-Chloro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(N4CCOC4=O)c(Cl)c3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H17ClF3N3O6/c1-12-13(3-2-4-16(12)23(25,26)27)10-30-19(31)15(20(32)33)11-29(21(30)34)14-5-6-18(17(24)9-14)28-7-8-36-22(28)35/h2-6,9,11H,7-8,10H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337773
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[3,5-dich...)
Show SMILES OC(=O)c1cn(-c2cc(Cl)c(N3CCNC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H14Cl3F3N4O5/c23-14-6-11(7-15(24)17(14)30-5-4-29-20(30)36)31-9-12(19(34)35)18(33)32(21(31)37)8-10-2-1-3-13(16(10)25)22(26,27)28/h1-3,6-7,9H,4-5,8H2,(H,29,36)(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337758
PNG
(1-[3-Chloro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Show SMILES OC(=O)c1cn(-c2ccc(N3CCOC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H14Cl2F3N3O6/c23-15-8-12(4-5-16(15)28-6-7-36-21(28)35)29-10-13(19(32)33)18(31)30(20(29)34)9-11-2-1-3-14(17(11)24)22(25,26)27/h1-5,8,10H,6-7,9H2,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337793
PNG
(2,4-Dioxo-1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C24H18F3N3O6/c25-24(26,27)18-3-1-2-16-15(18)8-9-19(16)30-20(31)17(21(32)33)12-29(22(30)34)14-6-4-13(5-7-14)28-10-11-36-23(28)35/h1-7,12,19H,8-11H2,(H,32,33)/t19-/m1/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337755
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H15ClF3N3O6/c23-17-12(2-1-3-16(17)22(24,25)26)10-29-18(30)15(19(31)32)11-28(20(29)33)14-6-4-13(5-7-14)27-8-9-35-21(27)34/h1-7,11H,8-10H2,(H,31,32)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337788
PNG
(1-(3,4-Dimethoxyphenyl)-2,4-dioxo-3-[4-(trifluorom...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(C2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C23H19F3N2O6/c1-33-18-9-6-12(10-19(18)34-2)27-11-15(21(30)31)20(29)28(22(27)32)17-8-7-13-14(17)4-3-5-16(13)23(24,25)26/h3-6,9-11,17H,7-8H2,1-2H3,(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337770
PNG
(3-[2,3-Bis(trifluoromethyl)benzyl]-2,4-dioxo-1-[4-...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(c2C(F)(F)F)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H15F6N3O6/c24-22(25,26)16-3-1-2-12(17(16)23(27,28)29)10-32-18(33)15(19(34)35)11-31(20(32)36)14-6-4-13(5-7-14)30-8-9-38-21(30)37/h1-7,11H,8-10H2,(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337690
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCOC3=O)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H18F3N3O6/c1-13-14(3-2-4-18(13)23(24,25)26)11-29-19(30)17(20(31)32)12-28(21(29)33)16-7-5-15(6-8-16)27-9-10-35-22(27)34/h2-8,12H,9-11H2,1H3,(H,31,32)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337720
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-n3ccnn3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C22H16F3N5O4/c1-13-14(3-2-4-18(13)22(23,24)25)11-29-19(31)17(20(32)33)12-28(21(29)34)15-5-7-16(8-6-15)30-10-9-26-27-30/h2-10,12H,11H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337802
PNG
(Ethyl 2,4-dioxo-1-[4-(2-oxo-1,3-oxazolidin-3-yl)ph...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(C2CCCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C27H24F3N3O6/c1-2-38-24(35)20-15-32(17-11-9-16(10-12-17)31-13-14-39-26(31)37)25(36)33(23(20)34)22-8-4-5-18-19(22)6-3-7-21(18)27(28,29)30/h3,6-7,9-12,15,22H,2,4-5,8,13-14H2,1H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337789
PNG
(3-[2,3-Bis(trifluoromethyl)benzyl]-1-(3,4-dimethox...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C(F)(F)F)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H16F6N2O6/c1-35-15-7-6-12(8-16(15)36-2)29-10-13(19(32)33)18(31)30(20(29)34)9-11-4-3-5-14(21(23,24)25)17(11)22(26,27)28/h3-8,10H,9H2,1-2H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337683
PNG
(1-[3-Fluoro-4-(2-oxoimidazolidin-1-yl)phenyl]-3-[2...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(N4CCNC4=O)c(F)c3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H18F4N4O5/c1-12-13(3-2-4-16(12)23(25,26)27)10-31-19(32)15(20(33)34)11-30(22(31)36)14-5-6-18(17(24)9-14)29-8-7-28-21(29)35/h2-6,9,11H,7-8,10H2,1H3,(H,28,35)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337708
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)C3CCC(=O)N3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O5/c1-13-15(3-2-4-18(13)24(25,26)27)11-30-21(32)17(22(33)34)12-29(23(30)35)16-7-5-14(6-8-16)19-9-10-20(31)28-19/h2-8,12,19H,9-11H2,1H3,(H,28,31)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337764
PNG
(1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3F)N3CCOC3=O)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H17F4N3O6/c1-12-13(3-2-4-16(12)23(25,26)27)10-30-19(31)15(20(32)33)11-29(21(30)34)18-6-5-14(9-17(18)24)28-7-8-36-22(28)35/h2-6,9,11H,7-8,10H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337761
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[3-methyl...)
Show SMILES Cc1cc(ccc1N1CCOC1=O)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H17ClF3N3O6/c1-12-9-14(5-6-17(12)28-7-8-36-22(28)35)29-11-15(20(32)33)19(31)30(21(29)34)10-13-3-2-4-16(18(13)24)23(25,26)27/h2-6,9,11H,7-8,10H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337805
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)N3CNC(=O)C3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H19F3N4O5/c1-13-14(3-2-4-18(13)23(24,25)26)9-30-20(32)17(21(33)34)10-29(22(30)35)16-7-5-15(6-8-16)28-11-19(31)27-12-28/h2-8,10H,9,11-12H2,1H3,(H,27,31)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337765
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[3,5-dich...)
Show SMILES OC(=O)c1cn(-c2cc(Cl)c(N3CCOC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H13Cl3F3N3O6/c23-14-6-11(7-15(24)17(14)29-4-5-37-21(29)36)30-9-12(19(33)34)18(32)31(20(30)35)8-10-2-1-3-13(16(10)25)22(26,27)28/h1-3,6-7,9H,4-5,8H2,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337760
PNG
(1-[3-Methyl-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Show SMILES Cc1cc(ccc1N1CCOC1=O)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H20F3N3O6/c1-13-10-16(6-7-19(13)28-8-9-36-23(28)35)29-12-17(21(32)33)20(31)30(22(29)34)11-15-4-3-5-18(14(15)2)24(25,26)27/h3-7,10,12H,8-9,11H2,1-2H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337739
PNG
(Ethyl 3-[2-chloro-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H19ClF3N3O6/c1-2-36-21(33)17-13-30(16-8-6-15(7-9-16)29-10-11-37-23(29)35)22(34)31(20(17)32)12-14-4-3-5-18(19(14)25)24(26,27)28/h3-9,13H,2,10-12H2,1H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337801
PNG
(3-(5-Chloro-1,2,3,4-tetrahydronaphthalen-1-yl)-2,4...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(C2CCCc3c(Cl)cccc23)c1=O
Show InChI InChI=1S/C24H20ClN3O6/c25-19-5-1-4-17-16(19)3-2-6-20(17)28-21(29)18(22(30)31)13-27(23(28)32)15-9-7-14(8-10-15)26-11-12-34-24(26)33/h1,4-5,7-10,13,20H,2-3,6,11-12H2,(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337676
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCNC3=O)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H19F3N4O5/c1-13-14(3-2-4-18(13)23(24,25)26)11-30-19(31)17(20(32)33)12-29(22(30)35)16-7-5-15(6-8-16)28-10-9-27-21(28)34/h2-8,12H,9-11H2,1H3,(H,27,34)(H,32,33)
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Bayer Pharma Aktiengesellschaft

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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337747
PNG
(Ethyl 3-[2-chloro-3-(trifluoromethyl)benzyl]-1-[3,...)
Show SMILES CCOC(=O)c1cn(-c2cc(Cl)c(N3CCNC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H18Cl3F3N4O5/c1-2-39-21(36)14-11-33(13-8-16(25)19(17(26)9-13)32-7-6-31-22(32)37)23(38)34(20(14)35)10-12-4-3-5-15(18(12)27)24(28,29)30/h3-5,8-9,11H,2,6-7,10H2,1H3,(H,31,37)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337748
PNG
(Ethyl 1-[3,5-dichloro-4-(2-oxoimidazolidin-1-yl)ph...)
Show SMILES CCOC(=O)c1cn(-c2cc(Cl)c(N3CCNC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H21Cl2F3N4O5/c1-3-39-22(36)16-12-33(15-9-18(26)20(19(27)10-15)32-8-7-31-23(32)37)24(38)34(21(16)35)11-14-5-4-6-17(13(14)2)25(28,29)30/h4-6,9-10,12H,3,7-8,11H2,1-2H3,(H,31,37)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337798
PNG
(2,4-Dioxo-1-[4-(2-oxoimidazolidin-1-yl)phenyl]-3-[...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(C2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C24H19F3N4O5/c25-24(26,27)18-3-1-2-16-15(18)8-9-19(16)31-20(32)17(21(33)34)12-30(23(31)36)14-6-4-13(5-7-14)29-11-10-28-22(29)35/h1-7,12,19H,8-11H2,(H,28,35)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337709
PNG
(3-(3-Chloro-2-nitrobenzyl)-2,4-dioxo-1-[4-(2-oxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(Cl)c2[N+]([O-])=O)c1=O
Show InChI InChI=1S/C21H15ClN4O8/c22-16-3-1-2-12(17(16)26(32)33)10-25-18(27)15(19(28)29)11-24(20(25)30)14-6-4-13(5-7-14)23-8-9-34-21(23)31/h1-7,11H,8-10H2,(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337762
PNG
(3-(2,3-Dichlorobenzyl)-1-[2-fluoro-4-(2-oxo-1,3-ox...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2F)N2CCOC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C21H14Cl2FN3O6/c22-14-3-1-2-11(17(14)23)9-27-18(28)13(19(29)30)10-26(20(27)31)16-5-4-12(8-15(16)24)25-6-7-33-21(25)32/h1-5,8,10H,6-7,9H2,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337791
PNG
(3-(4-Chloro-2,3-dihydro-1H-inden-1-yl)-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(C2CCc3c2cccc3Cl)c1=O
Show InChI InChI=1S/C23H18ClN3O6/c24-18-3-1-2-16-15(18)8-9-19(16)27-20(28)17(21(29)30)12-26(22(27)31)14-6-4-13(5-7-14)25-10-11-33-23(25)32/h1-7,12,19H,8-11H2,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337694
PNG
(1-(3,4-Dimethoxyphenyl)-3-[2-methyl-3-(trifluorome...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H19F3N2O6/c1-12-13(5-4-6-16(12)22(23,24)25)10-27-19(28)15(20(29)30)11-26(21(27)31)14-7-8-17(32-2)18(9-14)33-3/h4-9,11H,10H2,1-3H3,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337763
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[2-fluoro...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2F)N2CCOC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H14ClF4N3O6/c23-17-11(2-1-3-14(17)22(25,26)27)9-30-18(31)13(19(32)33)10-29(20(30)34)16-5-4-12(8-15(16)24)28-6-7-36-21(28)35/h1-5,8,10H,6-7,9H2,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337769
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[2-methyl...)
Show SMILES Cc1cc(ccc1-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O)N1CCOC1=O
Show InChI InChI=1S/C23H17ClF3N3O6/c1-12-9-14(28-7-8-36-22(28)35)5-6-17(12)29-11-15(20(32)33)19(31)30(21(29)34)10-13-3-2-4-16(18(13)24)23(25,26)27/h2-6,9,11H,7-8,10H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337689
PNG
(3-[3-Fluoro-2-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C22H15F4N3O6/c23-16-3-1-2-12(17(16)22(24,25)26)10-29-18(30)15(19(31)32)11-28(20(29)33)14-6-4-13(5-7-14)27-8-9-35-21(27)34/h1-7,11H,8-10H2,(H,31,32)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337757
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H16ClF3N4O5/c23-17-12(2-1-3-16(17)22(24,25)26)10-30-18(31)15(19(32)33)11-29(21(30)35)14-6-4-13(5-7-14)28-9-8-27-20(28)34/h1-7,11H,8-10H2,(H,27,34)(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337768
PNG
(1-[2-Methyl-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Show SMILES Cc1cc(ccc1-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O)N1CCOC1=O
Show InChI InChI=1S/C24H20F3N3O6/c1-13-10-16(28-8-9-36-23(28)35)6-7-19(13)29-12-17(21(32)33)20(31)30(22(29)34)11-15-4-3-5-18(14(15)2)24(25,26)27/h3-7,10,12H,8-9,11H2,1-2H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337699
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCCOC3=O)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O6/c1-14-15(4-2-5-19(14)24(25,26)27)12-30-20(31)18(21(32)33)13-29(22(30)34)17-8-6-16(7-9-17)28-10-3-11-36-23(28)35/h2,4-9,13H,3,10-12H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337795
PNG
(Ethyl 1-[2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phe...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2F)N2CCOC2=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C26H21F4N3O6/c1-2-38-23(35)17-13-32(21-8-6-14(12-19(21)27)31-10-11-39-25(31)37)24(36)33(22(17)34)20-9-7-15-16(20)4-3-5-18(15)26(28,29)30/h3-6,8,12-13,20H,2,7,9-11H2,1H3/t20-/m1/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337785
PNG
(3-(3-Chloro-2-methylbenzyl)-2,4-dioxo-1-[4-(2-oxo-...)
Show SMILES Cc1c(Cl)cccc1Cn1c(=O)c(cn(-c2ccc(cc2)N2CCOC2=O)c1=O)C(O)=O
Show InChI InChI=1S/C22H18ClN3O6/c1-13-14(3-2-4-18(13)23)11-26-19(27)17(20(28)29)12-25(21(26)30)16-7-5-15(6-8-16)24-9-10-32-22(24)31/h2-8,12H,9-11H2,1H3,(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337790
PNG
(3-(4-Chloro-2,3-dihydro-1H-inden-1-yl)-1-(3,4-dime...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(C2CCc3c2cccc3Cl)c1=O
Show InChI InChI=1S/C22H19ClN2O6/c1-30-18-9-6-12(10-19(18)31-2)24-11-15(21(27)28)20(26)25(22(24)29)17-8-7-13-14(17)4-3-5-16(13)23/h3-6,9-11,17H,7-8H2,1-2H3,(H,27,28)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337794
PNG
(1-[3-Chloro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-2...)
Show SMILES OC(=O)c1cn(-c2ccc(N3CCOC3=O)c(Cl)c2)c(=O)n(C2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C24H17ClF3N3O6/c25-17-10-12(4-6-19(17)29-8-9-37-23(29)36)30-11-15(21(33)34)20(32)31(22(30)35)18-7-5-13-14(18)2-1-3-16(13)24(26,27)28/h1-4,6,10-11,18H,5,7-9H2,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337682
PNG
(1-[3-Fluoro-4-(2-oxoimidazolidin-1-yl)phenyl]-3-(2...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(N4CCNC4=O)c(F)c3)c2=O)C(O)=O)cccc1N([O-])=O
Show InChI InChI=1S/C22H18FN5O7/c1-12-13(3-2-4-17(12)28(34)35)10-27-19(29)15(20(30)31)11-26(22(27)33)14-5-6-18(16(23)9-14)25-8-7-24-21(25)32/h2-6,9,11H,7-8,10H2,1H3,(H2-,24,30,31,32,34,35)/q-1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337685
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxo-2,3-d...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)-n2cc[nH]c2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337777
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(CCN4CCOC4=O)cc3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O6/c1-15-17(3-2-4-20(15)25(26,27)28)13-31-21(32)19(22(33)34)14-30(23(31)35)18-7-5-16(6-8-18)9-10-29-11-12-37-24(29)36/h2-8,14H,9-13H2,1H3,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337743
PNG
(Ethyl 1-[2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phe...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2F)N2CCOC2=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H21F4N3O6/c1-3-37-22(34)17-13-31(20-8-7-16(11-19(20)26)30-9-10-38-24(30)36)23(35)32(21(17)33)12-15-5-4-6-18(14(15)2)25(27,28)29/h4-8,11,13H,3,9-10,12H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337688
PNG
(3-(2-Methyl-3-nitrobenzyl)-2,4-dioxo-1-[4-(2-oxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCOC3=O)c2=O)C(O)=O)cccc1N([O-])=O
Show InChI InChI=1S/C22H18N4O8/c1-13-14(3-2-4-18(13)26(32)33)11-25-19(27)17(20(28)29)12-24(21(25)30)16-7-5-15(6-8-16)23-9-10-34-22(23)31/h2-8,12H,9-11H2,1H3,(H-,28,29,32,33)/q-1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337734
PNG
(3-[(3-Chloro-4-methyl-2-thienyl)methyl]-2,4-dioxo-...)
Show SMILES Cc1csc(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCOC3=O)c2=O)C(O)=O)c1Cl
Show InChI InChI=1S/C20H16ClN3O6S/c1-11-10-31-15(16(11)21)9-24-17(25)14(18(26)27)8-23(19(24)28)13-4-2-12(3-5-13)22-6-7-30-20(22)29/h2-5,8,10H,6-7,9H2,1H3,(H,26,27)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337742
PNG
(Ethyl 1-[3-chloro-4-(2-oxo-1,3-oxazolidin-3-yl)phe...)
Show SMILES CCOC(=O)c1cn(-c2ccc(N3CCOC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H21ClF3N3O6/c1-3-37-22(34)17-13-31(16-7-8-20(19(26)11-16)30-9-10-38-24(30)36)23(35)32(21(17)33)12-15-5-4-6-18(14(15)2)25(27,28)29/h4-8,11,13H,3,9-10,12H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337674
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-(4-methox...)
Show SMILES COc1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C20H14ClF3N2O5/c1-31-13-7-5-12(6-8-13)25-10-14(18(28)29)17(27)26(19(25)30)9-11-3-2-4-15(16(11)21)20(22,23)24/h2-8,10H,9H2,1H3,(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337651
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CNC(=O)C2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H23F3N4O5/c1-3-37-23(35)19-12-31(18-9-7-17(8-10-18)30-13-21(33)29-14-30)24(36)32(22(19)34)11-16-5-4-6-20(15(16)2)25(26,27)28/h4-10,12H,3,11,13-14H2,1-2H3,(H,29,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337715
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCOCC3=O)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O6/c1-14-15(3-2-4-19(14)24(25,26)27)11-30-21(32)18(22(33)34)12-29(23(30)35)17-7-5-16(6-8-17)28-9-10-36-13-20(28)31/h2-8,12H,9-11,13H2,1H3,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337775
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(CN4CCOC4=O)cc3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O6/c1-14-16(3-2-4-19(14)24(25,26)27)12-30-20(31)18(21(32)33)13-29(22(30)34)17-7-5-15(6-8-17)11-28-9-10-36-23(28)35/h2-8,13H,9-12H2,1H3,(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337753
PNG
(Ethyl 2,4-dioxo-1-[4-(2-oxo-1,3-oxazolidin-3-yl)ph...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C26H22F3N3O6/c1-2-37-23(34)19-14-31(16-8-6-15(7-9-16)30-12-13-38-25(30)36)24(35)32(22(19)33)21-11-10-17-18(21)4-3-5-20(17)26(27,28)29/h3-9,14,21H,2,10-13H2,1H3/t21-/m1/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337745
PNG
(Ethyl 1-[3-chloro-4-(2-oxoimidazolidin-1-yl)phenyl...)
Show SMILES CCOC(=O)c1cn(-c2ccc(N3CCNC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H22ClF3N4O5/c1-3-38-22(35)17-13-32(16-7-8-20(19(26)11-16)31-10-9-30-23(31)36)24(37)33(21(17)34)12-15-5-4-6-18(14(15)2)25(27,28)29/h4-8,11,13H,3,9-10,12H2,1-2H3,(H,30,36)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337782
PNG
(3-(3-Chloro-2-methylbenzyl)-1-(3,4-dimethoxyphenyl...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2C)c1=O
Show InChI InChI=1S/C21H19ClN2O6/c1-12-13(5-4-6-16(12)22)10-24-19(25)15(20(26)27)11-23(21(24)28)14-7-8-17(29-2)18(9-14)30-3/h4-9,11H,10H2,1-3H3,(H,26,27)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337691
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxo-1,3-o...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C21H15Cl2N3O6/c22-16-3-1-2-12(17(16)23)10-26-18(27)15(19(28)29)11-25(20(26)30)14-6-4-13(5-7-14)24-8-9-32-21(24)31/h1-7,11H,8-10H2,(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337800
PNG
(Ethyl 3-(5-chloro-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(C2CCCc3c(Cl)cccc23)c1=O
Show InChI InChI=1S/C26H24ClN3O6/c1-2-35-24(32)20-15-29(17-11-9-16(10-12-17)28-13-14-36-26(28)34)25(33)30(23(20)31)22-8-4-5-18-19(22)6-3-7-21(18)27/h3,6-7,9-12,15,22H,2,4-5,8,13-14H2,1H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337804
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(4-oxoimidaz...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CNC(=O)C2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C21H16Cl2N4O5/c22-16-3-1-2-12(18(16)23)8-27-19(29)15(20(30)31)9-26(21(27)32)14-6-4-13(5-7-14)25-10-17(28)24-11-25/h1-7,9H,8,10-11H2,(H,24,28)(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337704
PNG
(1-[3,5-Difluoro-4-(2-oxoimidazolidin-1-yl)phenyl]-...)
Show SMILES OC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C22H14F6N4O5/c23-13-3-1-2-10(16(13)22(26,27)28)8-32-18(33)12(19(34)35)9-31(21(32)37)11-6-14(24)17(15(25)7-11)30-5-4-29-20(30)36/h1-3,6-7,9H,4-5,8H2,(H,29,36)(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337703
PNG
(3-(2-Chloro-3-(trifluoromethyl)benzyl)-1-[3,5-difl...)
Show SMILES OC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H14ClF5N4O5/c23-16-10(2-1-3-13(16)22(26,27)28)8-32-18(33)12(19(34)35)9-31(21(32)37)11-6-14(24)17(15(25)7-11)30-5-4-29-20(30)36/h1-3,6-7,9H,4-5,8H2,(H,29,36)(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337678
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxoimidaz...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C21H16Cl2N4O5/c22-16-3-1-2-12(17(16)23)10-27-18(28)15(19(29)30)11-26(21(27)32)14-6-4-13(5-7-14)25-9-8-24-20(25)31/h1-7,11H,8-10H2,(H,24,31)(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337713
PNG
(1-(3-Fluoro-4-{[(2-methoxyethyl)carbamoyl]amino}ph...)
Show SMILES COCCNC(=O)Nc1ccc(cc1F)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H22F4N4O6/c1-13-14(4-3-5-17(13)24(26,27)28)11-32-20(33)16(21(34)35)12-31(23(32)37)15-6-7-19(18(25)10-15)30-22(36)29-8-9-38-2/h3-7,10,12H,8-9,11H2,1-2H3,(H,34,35)(H2,29,30,36)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337701
PNG
(1-[3,5-Difluoro-4-(2-oxoimidazolidin-1-yl)phenyl]-...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3cc(F)c(N4CCNC4=O)c(F)c3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H17F5N4O5/c1-11-12(3-2-4-15(11)23(26,27)28)9-32-19(33)14(20(34)35)10-31(22(32)37)13-7-16(24)18(17(25)8-13)30-6-5-29-21(30)36/h2-4,7-8,10H,5-6,9H2,1H3,(H,29,36)(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337669
PNG
(Ethyl 1-(3,4-dimethoxyphenyl)-3-[2-methyl-3-(trifl...)
Show SMILES CCOC(=O)c1cn(-c2ccc(OC)c(OC)c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H23F3N2O6/c1-5-35-22(31)17-13-28(16-9-10-19(33-3)20(11-16)34-4)23(32)29(21(17)30)12-15-7-6-8-18(14(15)2)24(25,26)27/h6-11,13H,5,12H2,1-4H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337681
PNG
(3-(2,3-Dichlorobenzyl)-1-[3-fluoro-4-(2-oxoimidazo...)
Show SMILES OC(=O)c1cn(-c2ccc(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C21H15Cl2FN4O5/c22-14-3-1-2-11(17(14)23)9-28-18(29)13(19(30)31)10-27(21(28)33)12-4-5-16(15(24)8-12)26-7-6-25-20(26)32/h1-5,8,10H,6-7,9H2,(H,25,32)(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337771
PNG
(3-[3-(Difluoromethyl)-2-methylbenzyl]-1-(3,4-dimet...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2cccc(C(F)F)c2C)c1=O
Show InChI InChI=1S/C22H20F2N2O6/c1-12-13(5-4-6-15(12)19(23)24)10-26-20(27)16(21(28)29)11-25(22(26)30)14-7-8-17(31-2)18(9-14)32-3/h4-9,11,19H,10H2,1-3H3,(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337735
PNG
(3-[(3-Chloro-4-methyl-2-thienyl)methyl]-1-(3,4-dim...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2scc(C)c2Cl)c1=O
Show InChI InChI=1S/C19H17ClN2O6S/c1-10-9-29-15(16(10)20)8-22-17(23)12(18(24)25)7-21(19(22)26)11-4-5-13(27-2)14(6-11)28-3/h4-7,9H,8H2,1-3H3,(H,24,25)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337797
PNG
(Ethyl 2,4-dioxo-1-[4-(2-oxoimidazolidin-1-yl)pheny...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C26H23F3N4O5/c1-2-38-23(35)19-14-32(16-8-6-15(7-9-16)31-13-12-30-24(31)36)25(37)33(22(19)34)21-11-10-17-18(21)4-3-5-20(17)26(27,28)29/h3-9,14,21H,2,10-13H2,1H3,(H,30,36)/t21-/m1/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337714
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(3-oxomorpho...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOCC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C22H17Cl2N3O6/c23-17-3-1-2-13(19(17)24)10-27-20(29)16(21(30)31)11-26(22(27)32)15-6-4-14(5-7-15)25-8-9-33-12-18(25)28/h1-7,11H,8-10,12H2,(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337783
PNG
(1-(3,4-Dimethoxyphenyl)-3-(3-fluoro-2-methylbenzyl...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2cccc(F)c2C)c1=O
Show InChI InChI=1S/C21H19FN2O6/c1-12-13(5-4-6-16(12)22)10-24-19(25)15(20(26)27)11-23(21(24)28)14-7-8-17(29-2)18(9-14)30-3/h4-9,11H,10H2,1-3H3,(H,26,27)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337711
PNG
(1-[4-(2-Amino-2-oxoethoxy)phenyl]-3-(2-methyl-3-ni...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(OCC(N)=O)cc3)c2=O)C(O)=O)cccc1[N+]([O-])=O
Show InChI InChI=1S/C21H18N4O8/c1-12-13(3-2-4-17(12)25(31)32)9-24-19(27)16(20(28)29)10-23(21(24)30)14-5-7-15(8-6-14)33-11-18(22)26/h2-8,10H,9,11H2,1H3,(H2,22,26)(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337677
PNG
(3-(2,3-Dimethylbenzyl)-2,4-dioxo-1-[4-(2-oxoimidaz...)
Show SMILES Cc1cccc(Cn2c(=O)c(cn(-c3ccc(cc3)N3CCNC3=O)c2=O)C(O)=O)c1C
Show InChI InChI=1S/C23H22N4O5/c1-14-4-3-5-16(15(14)2)12-27-20(28)19(21(29)30)13-26(23(27)32)18-8-6-17(7-9-18)25-11-10-24-22(25)31/h3-9,13H,10-12H2,1-2H3,(H,24,31)(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337744
PNG
(Ethyl 3-[2-chloro-3-(trifluoromethyl)benzyl]-1-[3,...)
Show SMILES CCOC(=O)c1cn(-c2cc(Cl)c(N3CCOC3=O)c(Cl)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H17Cl3F3N3O6/c1-2-38-21(35)14-11-32(13-8-16(25)19(17(26)9-13)31-6-7-39-23(31)37)22(36)33(20(14)34)10-12-4-3-5-15(18(12)27)24(28,29)30/h3-5,8-9,11H,2,6-7,10H2,1H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337712
PNG
(1-[4-(2-Amino-2-oxoethoxy)phenyl]-3-(2,3-dichlorob...)
Show SMILES NC(=O)COc1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C20H15Cl2N3O6/c21-15-3-1-2-11(17(15)22)8-25-18(27)14(19(28)29)9-24(20(25)30)12-4-6-13(7-5-12)31-10-16(23)26/h1-7,9H,8,10H2,(H2,23,26)(H,28,29)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337687
PNG
(3-[3-Fluoro-2-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCCC2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C23H17F4N3O5/c24-17-4-1-3-13(19(17)23(25,26)27)11-30-20(32)16(21(33)34)12-29(22(30)35)15-8-6-14(7-9-15)28-10-2-5-18(28)31/h1,3-4,6-9,12H,2,5,10-11H2,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337731
PNG
(1-[4-(5-Amino-1,3,4-oxadiazol-2-yl)phenyl]-3-[2-ch...)
Show SMILES Nc1nnc(o1)-c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C21H13ClF3N5O5/c22-15-11(2-1-3-14(15)21(23,24)25)8-30-17(31)13(18(32)33)9-29(20(30)34)12-6-4-10(5-7-12)16-27-28-19(26)35-16/h1-7,9H,8H2,(H2,26,28)(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337741
PNG
(Ethyl 3-[2-chloro-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H20ClF3N4O5/c1-2-37-21(34)17-13-31(16-8-6-15(7-9-16)30-11-10-29-22(30)35)23(36)32(20(17)33)12-14-4-3-5-18(19(14)25)24(26,27)28/h3-9,13H,2,10-12H2,1H3,(H,29,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337779
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[4-(4-met...)
Show SMILES CC1CN(C(=O)N1)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H18ClF3N4O5/c1-12-9-29(21(35)28-12)14-5-7-15(8-6-14)30-11-16(20(33)34)19(32)31(22(30)36)10-13-3-2-4-17(18(13)24)23(25,26)27/h2-8,11-12H,9-10H2,1H3,(H,28,35)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337756
PNG
(1-{4-[(5S)-5-(Acetamidomethyl)-2-oxo-1,3-oxazolidi...)
Show SMILES CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H20ClF3N4O7/c1-13(34)30-9-17-11-32(24(39)40-17)16-7-5-15(6-8-16)31-12-18(22(36)37)21(35)33(23(31)38)10-14-3-2-4-19(20(14)26)25(27,28)29/h2-8,12,17H,9-11H2,1H3,(H,30,34)(H,36,37)/t17-/m0/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337650
PNG
(Ethyl 3-[3-fluoro-2-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CNC(=O)C2)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C24H20F4N4O5/c1-2-37-22(35)17-11-31(16-8-6-15(7-9-16)30-12-19(33)29-13-30)23(36)32(21(17)34)10-14-4-3-5-18(25)20(14)24(26,27)28/h3-9,11H,2,10,12-13H2,1H3,(H,29,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337653
PNG
(Ethyl 1-[3-fluoro-4-(2-oxoimidazolidin-1-yl)phenyl...)
Show SMILES CCOC(=O)c1cn(-c2ccc(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H22F4N4O5/c1-3-38-22(35)17-13-32(16-7-8-20(19(26)11-16)31-10-9-30-23(31)36)24(37)33(21(17)34)12-15-5-4-6-18(14(15)2)25(27,28)29/h4-8,11,13H,3,9-10,12H2,1-2H3,(H,30,36)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337717
PNG
(1-[4-(2-Hydroxyethoxy)phenyl]-3-[2-methyl-3-(trifl...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(OCCO)cc3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C22H19F3N2O6/c1-13-14(3-2-4-18(13)22(23,24)25)11-27-19(29)17(20(30)31)12-26(21(27)32)15-5-7-16(8-6-15)33-10-9-28/h2-8,12,28H,9-11H2,1H3,(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337786
PNG
(3-(4-Methyl-2,3-dihydro-1H-inden-1-yl)-2,4-dioxo-1...)
Show SMILES Cc1cccc2C(CCc12)n1c(=O)c(cn(-c2ccc(cc2)N2CCOC2=O)c1=O)C(O)=O
Show InChI InChI=1S/C24H21N3O6/c1-14-3-2-4-18-17(14)9-10-20(18)27-21(28)19(22(29)30)13-26(23(27)31)16-7-5-15(6-8-16)25-11-12-33-24(25)32/h2-8,13,20H,9-12H2,1H3,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337646
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H23F3N4O5/c1-3-37-22(34)19-14-31(18-9-7-17(8-10-18)30-12-11-29-23(30)35)24(36)32(21(19)33)13-16-5-4-6-20(15(16)2)25(26,27)28/h4-10,14H,3,11-13H2,1-2H3,(H,29,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337656
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOCC2=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C26H24F3N3O6/c1-3-38-24(35)20-14-31(19-9-7-18(8-10-19)30-11-12-37-15-22(30)33)25(36)32(23(20)34)13-17-5-4-6-21(16(17)2)26(27,28)29/h4-10,14H,3,11-13,15H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337658
PNG
(Ethyl 1-[3,5-difluoro-4-(2-oxoimidazolidin-1-yl)ph...)
Show SMILES CCOC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H21F5N4O5/c1-3-39-22(36)16-12-33(15-9-18(26)20(19(27)10-15)32-8-7-31-23(32)37)24(38)34(21(16)35)11-14-5-4-6-17(13(14)2)25(28,29)30/h4-6,9-10,12H,3,7-8,11H2,1-2H3,(H,31,37)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337667
PNG
(Ethyl 3-(2-methyl-3-nitrobenzyl)-2,4-dioxo-1-[4-(2...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(c2C)[N+]([O-])=O)c1=O
Show InChI InChI=1S/C24H22N4O8/c1-3-35-22(30)19-14-26(18-9-7-17(8-10-18)25-11-12-36-24(25)32)23(31)27(21(19)29)13-16-5-4-6-20(15(16)2)28(33)34/h4-10,14H,3,11-13H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337799
PNG
(1-{4-[(Methoxycarbonyl)amino]phenyl}-3-[2-methyl-3...)
Show SMILES COC(=O)Nc1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H18F3N3O6/c1-12-13(4-3-5-17(12)22(23,24)25)10-28-18(29)16(19(30)31)11-27(21(28)33)15-8-6-14(7-9-15)26-20(32)34-2/h3-9,11H,10H2,1-2H3,(H,26,32)(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337700
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxo-1,3-o...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCCOC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C22H17Cl2N3O6/c23-17-4-1-3-13(18(17)24)11-27-19(28)16(20(29)30)12-26(21(27)31)15-7-5-14(6-8-15)25-9-2-10-33-22(25)32/h1,3-8,12H,2,9-11H2,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337732
PNG
(1-[4-(5-Amino-1,3,4-oxadiazol-2-yl)phenyl]-3-[2-me...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-c3nnc(N)o3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C22H16F3N5O5/c1-11-13(3-2-4-16(11)22(23,24)25)9-30-18(31)15(19(32)33)10-29(21(30)34)14-7-5-12(6-8-14)17-27-28-20(26)35-17/h2-8,10H,9H2,1H3,(H2,26,28)(H,32,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337684
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-n3cc[nH]c3=O)c2=O)C(O)=O)cccc1C(F)(F)F
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337754
PNG
(Ethyl 1-[3-chloro-4-(2-oxo-1,3-oxazolidin-3-yl)phe...)
Show SMILES CCOC(=O)c1cn(-c2ccc(N3CCOC3=O)c(Cl)c2)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1S/C26H21ClF3N3O6/c1-2-38-23(35)17-13-32(14-6-8-21(19(27)12-14)31-10-11-39-25(31)37)24(36)33(22(17)34)20-9-7-15-16(20)4-3-5-18(15)26(28,29)30/h3-6,8,12-13,20H,2,7,9-11H2,1H3/t20-/m1/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337680
PNG
(3-[3-Fluoro-2-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCCNC2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C23H18F4N4O5/c24-17-4-1-3-13(18(17)23(25,26)27)11-31-19(32)16(20(33)34)12-30(22(31)36)15-7-5-14(6-8-15)29-10-2-9-28-21(29)35/h1,3-8,12H,2,9-11H2,(H,28,35)(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337696
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-c3cc[nH]n3)c2=O)C(O)=O)cccc1C(F)(F)F
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337672
PNG
(1-[4-(Methylsulfinyl)phenyl]-2,4-dioxo-3-[3-(trifl...)
Show SMILES CS(=O)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C20H15F3N2O5S/c1-31(30)15-7-5-14(6-8-15)24-11-16(18(27)28)17(26)25(19(24)29)10-12-3-2-4-13(9-12)20(21,22)23/h2-9,11H,10H2,1H3,(H,27,28)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337727
PNG
(1-[4-(4-Methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-c3noc(=O)n3C)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O6/c1-12-14(4-3-5-17(12)23(24,25)26)10-30-19(31)16(20(32)33)11-29(21(30)34)15-8-6-13(7-9-15)18-27-36-22(35)28(18)2/h3-9,11H,10H2,1-2H3,(H,32,33)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337746
PNG
(Ethyl 1-[2-methyl-4-(2-oxo-1,3-oxazolidin-3-yl)phe...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2C)N2CCOC2=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C26H24F3N3O6/c1-4-37-23(34)19-14-31(21-9-8-18(12-15(21)2)30-10-11-38-25(30)36)24(35)32(22(19)33)13-17-6-5-7-20(16(17)3)26(27,28)29/h5-9,12,14H,4,10-11,13H2,1-3H3
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337718
PNG
(1-{4-[(2-Hydroxyethyl)amino]phenyl}-3-[2-methyl-3-...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(NCCO)cc3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C22H20F3N3O5/c1-13-14(3-2-4-18(13)22(23,24)25)11-28-19(30)17(20(31)32)12-27(21(28)33)16-7-5-15(6-8-16)26-9-10-29/h2-8,12,26,29H,9-11H2,1H3,(H,31,32)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337781
PNG
(1-{4-[(Methoxycarbonyl)(methyl)amino]phenyl}-3-[2-...)
Show SMILES COC(=O)N(C)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H20F3N3O6/c1-13-14(5-4-6-18(13)23(24,25)26)11-29-19(30)17(20(31)32)12-28(21(29)33)16-9-7-15(8-10-16)27(2)22(34)35-3/h4-10,12H,11H2,1-3H3,(H,31,32)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337671
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)C2CCC(=O)N2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C26H24F3N3O5/c1-3-37-24(35)19-14-31(18-9-7-16(8-10-18)21-11-12-22(33)30-21)25(36)32(23(19)34)13-17-5-4-6-20(15(17)2)26(27,28)29/h4-10,14,21H,3,11-13H2,1-2H3,(H,30,33)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337693
PNG
(1-(4-Methoxyphenyl)-3-[2-methyl-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C21H17F3N2O5/c1-12-13(4-3-5-17(12)21(22,23)24)10-26-18(27)16(19(28)29)11-25(20(26)30)14-6-8-15(31-2)9-7-14/h3-9,11H,10H2,1-2H3,(H,28,29)
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337792
PNG
(3-[3-Chloro-2-(trifluoromethyl)benzyl]-1-[4-(3,5-d...)
Show SMILES Cc1cc(C)n(n1)-c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C24H18ClF3N4O4/c1-13-10-14(2)32(29-13)17-8-6-16(7-9-17)30-12-18(22(34)35)21(33)31(23(30)36)11-15-4-3-5-19(25)20(15)24(26,27)28/h3-10,12H,11H2,1-2H3,(H,34,35)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337652
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCCOC2=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C26H24F3N3O6/c1-3-37-23(34)20-15-31(19-10-8-18(9-11-19)30-12-5-13-38-25(30)36)24(35)32(22(20)33)14-17-6-4-7-21(16(17)2)26(27,28)29/h4,6-11,15H,3,5,12-14H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337668
PNG
(Ethyl 3-[3-fluoro-2-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C24H19F4N3O6/c1-2-36-21(33)17-13-30(16-8-6-15(7-9-16)29-10-11-37-23(29)35)22(34)31(20(17)32)12-14-4-3-5-18(25)19(14)24(26,27)28/h3-9,13H,2,10-12H2,1H3
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337649
PNG
(Ethyl 3-(2,3-dichlorobenzyl)-2,4-dioxo-1-[4-(4-oxo...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CNC(=O)C2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C23H20Cl2N4O5/c1-2-34-22(32)17-11-28(16-8-6-15(7-9-16)27-12-19(30)26-13-27)23(33)29(21(17)31)10-14-4-3-5-18(24)20(14)25/h3-9,11H,2,10,12-13H2,1H3,(H,26,30)
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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337695
PNG
(1-(4-Ethoxyphenyl)-3-[3-fluoro-2-(trifluoromethyl)...)
Show SMILES CCOc1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C21H16F4N2O5/c1-2-32-14-8-6-13(7-9-14)26-11-15(19(29)30)18(28)27(20(26)31)10-12-4-3-5-16(22)17(12)21(23,24)25/h3-9,11H,2,10H2,1H3,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337660
PNG
(Ethyl 3-(2-chloro-3-(trifluoromethyl)benzyl)-1-[3,...)
Show SMILES CCOC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H18ClF5N4O5/c1-2-39-21(36)14-11-33(13-8-16(26)19(17(27)9-13)32-7-6-31-22(32)37)23(38)34(20(14)35)10-12-4-3-5-15(18(12)25)24(28,29)30/h3-5,8-9,11H,2,6-7,10H2,1H3,(H,31,37)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337787
PNG
(3-(2-Chloro-3,6-difluorobenzyl)-2,4-dioxo-1-[4-(2-...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2c(F)ccc(F)c2Cl)c1=O
Show InChI InChI=1S/C21H14ClF2N3O6/c22-17-13(15(23)5-6-16(17)24)9-27-18(28)14(19(29)30)10-26(20(27)31)12-3-1-11(2-4-12)25-7-8-33-21(25)32/h1-6,10H,7-9H2,(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337733
PNG
(1-[4-(5-Amino-1,3,4-oxadiazol-2-yl)phenyl]-3-(2,3-...)
Show SMILES Nc1nnc(o1)-c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C20H13Cl2N5O5/c21-14-3-1-2-11(15(14)22)8-27-17(28)13(18(29)30)9-26(20(27)31)12-6-4-10(5-7-12)16-24-25-19(23)32-16/h1-7,9H,8H2,(H2,23,25)(H,29,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337706
PNG
(3-[3-Chloro-2-(methylsulfanyl)benzyl]-1-(3,4-dimet...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2SC)c1=O
Show InChI InChI=1S/C21H19ClN2O6S/c1-29-16-8-7-13(9-17(16)30-2)23-11-14(20(26)27)19(25)24(21(23)28)10-12-5-4-6-15(22)18(12)31-3/h4-9,11H,10H2,1-3H3,(H,26,27)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337749
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(CCN3CCOC3=O)cc2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C27H26F3N3O6/c1-3-38-24(35)21-16-32(20-9-7-18(8-10-20)11-12-31-13-14-39-26(31)37)25(36)33(23(21)34)15-19-5-4-6-22(17(19)2)27(28,29)30/h4-10,16H,3,11-15H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337647
PNG
(Ethyl 3-(2,3-dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxo...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C23H20Cl2N4O5/c1-2-34-21(31)17-13-28(16-8-6-15(7-9-16)27-11-10-26-22(27)32)23(33)29(20(17)30)12-14-4-3-5-18(24)19(14)25/h3-9,13H,2,10-12H2,1H3,(H,26,32)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337705
PNG
(3-(2-Chloro-3-methylbenzyl)-1-[3,5-difluoro-4-(2-o...)
Show SMILES Cc1cccc(Cn2c(=O)c(cn(-c3cc(F)c(N4CCNC4=O)c(F)c3)c2=O)C(O)=O)c1Cl
Show InChI InChI=1S/C22H17ClF2N4O5/c1-11-3-2-4-12(17(11)23)9-29-19(30)14(20(31)32)10-28(22(29)34)13-7-15(24)18(16(25)8-13)27-6-5-26-21(27)33/h2-4,7-8,10H,5-6,9H2,1H3,(H,26,33)(H,31,32)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337716
PNG
(1-[4-(2-Hydroxyethoxy)phenyl]-3-(2-methyl-3-nitrob...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(OCCO)cc3)c2=O)C(O)=O)cccc1[N+]([O-])=O
Show InChI InChI=1S/C21H19N3O8/c1-13-14(3-2-4-18(13)24(30)31)11-23-19(26)17(20(27)28)12-22(21(23)29)15-5-7-16(8-6-15)32-10-9-25/h2-8,12,25H,9-11H2,1H3,(H,27,28)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337778
PNG
(3-[2-Chloro-3-(trifluoromethyl)benzyl]-1-[4-(3-met...)
Show SMILES CN1CCN(C1=O)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H18ClF3N4O5/c1-28-9-10-29(21(28)35)14-5-7-15(8-6-14)30-12-16(20(33)34)19(32)31(22(30)36)11-13-3-2-4-17(18(13)24)23(25,26)27/h2-8,12H,9-11H2,1H3,(H,33,34)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337719
PNG
(1-{4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]phen...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-n3cc(CO)nn3)c2=O)C(O)=O)cccc1C(F)(F)F
Show InChI InChI=1S/C23H18F3N5O5/c1-13-14(3-2-4-19(13)23(24,25)26)9-30-20(33)18(21(34)35)11-29(22(30)36)16-5-7-17(8-6-16)31-10-15(12-32)27-28-31/h2-8,10-11,32H,9,12H2,1H3,(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337673
PNG
(Ethyl 1-[4-(1,1-dioxido-1,2,5-thiadiazolidin-2-yl)...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCNS2(=O)=O)c(=O)n(Cc2cccc(c2C)[N+]([O-])=O)c1=O
Show InChI InChI=1S/C23H23N5O8S/c1-3-36-22(30)19-14-25(17-7-9-18(10-8-17)27-12-11-24-37(27,34)35)23(31)26(21(19)29)13-16-5-4-6-20(15(16)2)28(32)33/h4-10,14,24H,3,11-13H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337784
PNG
(1-(3,4-Dimethoxyphenyl)-2,4-dioxo-3-{1-[3-(trifluo...)
Show SMILES CCC(c1cccc(c1)C(F)(F)F)n1c(=O)c(cn(-c2ccc(OC)c(OC)c2)c1=O)C(O)=O
Show InChI InChI=1S/C23H21F3N2O6/c1-4-17(13-6-5-7-14(10-13)23(24,25)26)28-20(29)16(21(30)31)12-27(22(28)32)15-8-9-18(33-2)19(11-15)34-3/h5-12,17H,4H2,1-3H3,(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337679
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxotetrah...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCCNC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C22H18Cl2N4O5/c23-17-4-1-3-13(18(17)24)11-28-19(29)16(20(30)31)12-27(22(28)33)15-7-5-14(6-8-15)26-10-2-9-25-21(26)32/h1,3-8,12H,2,9-11H2,(H,25,32)(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337675
PNG
(3-(2,3-Dichlorobenzyl)-1-(4-methoxyphenyl)-2,4-dio...)
Show SMILES COc1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C19H14Cl2N2O5/c1-28-13-7-5-12(6-8-13)22-10-14(18(25)26)17(24)23(19(22)27)9-11-3-2-4-15(20)16(11)21/h2-8,10H,9H2,1H3,(H,25,26)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337697
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(1H-pyrazol-...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)-c2cc[nH]n2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337686
PNG
(3-(2,3-Dichlorobenzyl)-2,4-dioxo-1-[4-(2-oxopyrrol...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)N2CCCC2=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C22H17Cl2N3O5/c23-17-4-1-3-13(19(17)24)11-27-20(29)16(21(30)31)12-26(22(27)32)15-8-6-14(7-9-15)25-10-2-5-18(25)28/h1,3-4,6-9,12H,2,5,10-11H2,(H,30,31)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337655
PNG
(Ethyl 3-(2,3-dichlorobenzyl)-1-[3-fluoro-4-(2-oxoi...)
Show SMILES CCOC(=O)c1cn(-c2ccc(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C23H19Cl2FN4O5/c1-2-35-21(32)15-12-29(14-6-7-18(17(26)10-14)28-9-8-27-22(28)33)23(34)30(20(15)31)11-13-4-3-5-16(24)19(13)25/h3-7,10,12H,2,8-9,11H2,1H3,(H,27,33)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337780
PNG
(1-[4-(4,4-Dimethyl-2-oxoimidazolidin-1-yl)phenyl]-...)
Show SMILES CC1(C)CN(C(=O)N1)c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C24H20F4N4O5/c1-23(2)12-32(21(36)29-23)15-8-6-14(7-9-15)30-11-16(20(34)35)19(33)31(22(30)37)10-13-4-3-5-17(25)18(13)24(26,27)28/h3-9,11H,10,12H2,1-2H3,(H,29,36)(H,34,35)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337772
PNG
(3-(2,3-Dihydro-1H-inden-1-yl)-1-(3,4-dimethoxyphen...)
Show SMILES COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(C2CCc3ccccc23)c1=O
Show InChI InChI=1S/C22H20N2O6/c1-29-18-10-8-14(11-19(18)30-2)23-12-16(21(26)27)20(25)24(22(23)28)17-9-7-13-5-3-4-6-15(13)17/h3-6,8,10-12,17H,7,9H2,1-2H3,(H,26,27)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337730
PNG
(Ethyl 3-[(3-chloro-4-methyl-2-thienyl)methyl]-1-(3...)
Show SMILES CCOC(=O)c1cn(-c2ccc(OC)c(OC)c2)c(=O)n(Cc2scc(C)c2Cl)c1=O
Show InChI InChI=1S/C21H21ClN2O6S/c1-5-30-20(26)14-9-23(13-6-7-15(28-3)16(8-13)29-4)21(27)24(19(14)25)10-17-18(22)12(2)11-31-17/h6-9,11H,5,10H2,1-4H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337648
PNG
(Ethyl 3-(2,3-dimethylbenzyl)-2,4-dioxo-1-[4-(2-oxo...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCNC2=O)c(=O)n(Cc2cccc(C)c2C)c1=O
Show InChI InChI=1S/C25H26N4O5/c1-4-34-23(31)21-15-28(20-10-8-19(9-11-20)27-13-12-26-24(27)32)25(33)29(22(21)30)14-18-7-5-6-16(2)17(18)3/h5-11,15H,4,12-14H2,1-3H3,(H,26,32)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337740
PNG
(Ethyl 1-{4-[(5S)-5-(acetamidomethyl)-2-oxo-1,3-oxa...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2C[C@H](CNC(C)=O)OC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C27H24ClF3N4O7/c1-3-41-24(38)20-14-33(17-7-9-18(10-8-17)34-13-19(42-26(34)40)11-32-15(2)36)25(39)35(23(20)37)12-16-5-4-6-21(22(16)28)27(29,30)31/h4-10,14,19H,3,11-13H2,1-2H3,(H,32,36)/t19-/m0/s1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337729
PNG
(Ethyl 3-[(3-chloro-4-methyl-2-thienyl)methyl]-2,4-...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CCOC2=O)c(=O)n(Cc2scc(C)c2Cl)c1=O
Show InChI InChI=1S/C22H20ClN3O6S/c1-3-31-20(28)16-10-25(15-6-4-14(5-7-15)24-8-9-32-22(24)30)21(29)26(19(16)27)11-17-18(23)13(2)12-33-17/h4-7,10,12H,3,8-9,11H2,1-2H3
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337750
PNG
(Ethyl 3-[2-chloro-3-(trifluoromethyl)benzyl]-1-[4-...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CC(C)NC2=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H22ClF3N4O5/c1-3-38-22(35)18-13-32(17-9-7-16(8-10-17)31-11-14(2)30-23(31)36)24(37)33(21(18)34)12-15-5-4-6-19(20(15)26)25(27,28)29/h4-10,13-14H,3,11-12H2,1-2H3,(H,30,36)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337722
PNG
(Ethyl 1-[4-(5-amino-1,3,4-oxadiazol-2-yl)phenyl]-3...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)-c2nnc(N)o2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H20F3N5O5/c1-3-36-21(34)17-12-31(16-9-7-14(8-10-16)19-29-30-22(28)37-19)23(35)32(20(17)33)11-15-5-4-6-18(13(15)2)24(25,26)27/h4-10,12H,3,11H2,1-2H3,(H2,28,30)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337654
PNG
(Ethyl 1-[3-fluoro-4-(2-oxoimidazolidin-1-yl)phenyl...)
Show SMILES CCOC(=O)c1cn(-c2ccc(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(c2C)N([O-])=O)c1=O
Show InChI InChI=1S/C24H22FN5O7/c1-3-37-22(32)17-13-28(16-7-8-20(18(25)11-16)27-10-9-26-23(27)33)24(34)29(21(17)31)12-15-5-4-6-19(14(15)2)30(35)36/h4-8,11,13H,3,9-10,12H2,1-2H3,(H-,26,33,35,36)/q-1
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337662
PNG
(Ethyl 1-[3,5-difluoro-4-(2-oxoimidazolidin-1-yl)ph...)
Show SMILES CCOC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C24H18F6N4O5/c1-2-39-21(36)14-11-33(13-8-16(26)19(17(27)9-13)32-7-6-31-22(32)37)23(38)34(20(14)35)10-12-4-3-5-15(25)18(12)24(28,29)30/h3-5,8-9,11H,2,6-7,10H2,1H3,(H,31,37)
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Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337659
PNG
(Ethyl 3-(2,3-dichlorobenzyl)-1-[3,5-difluoro-4-(2-...)
Show SMILES CCOC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C23H18Cl2F2N4O5/c1-2-36-21(33)14-11-30(13-8-16(26)19(17(27)9-13)29-7-6-28-22(29)34)23(35)31(20(14)32)10-12-4-3-5-15(24)18(12)25/h3-5,8-9,11H,2,6-7,10H2,1H3,(H,28,34)
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n/an/a 625n/an/an/an/an/an/a



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US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337752
PNG
(Ethyl 1-{4-[(methoxycarbonyl)(methyl)amino]phenyl}...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N(C)C(=O)OC)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H24F3N3O6/c1-5-37-22(33)19-14-30(18-11-9-17(10-12-18)29(3)24(35)36-4)23(34)31(21(19)32)13-16-7-6-8-20(15(16)2)25(26,27)28/h6-12,14H,5,13H2,1-4H3
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US Patent
n/an/a 630n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337698
PNG
(3-[3-Fluoro-2-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES OC(=O)c1cn(-c2ccc(cc2)-n2cn[nH]c2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
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n/an/a 632n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337702
PNG
(3-(2,3-Dichlorobenzyl)-1-[3,5-difluoro-4-(2-oxoimi...)
Show SMILES OC(=O)c1cn(-c2cc(F)c(N3CCNC3=O)c(F)c2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C21H14Cl2F2N4O5/c22-13-3-1-2-10(16(13)23)8-29-18(30)12(19(31)32)9-28(21(29)34)11-6-14(24)17(15(25)7-11)27-5-4-26-20(27)33/h1-3,6-7,9H,4-5,8H2,(H,26,33)(H,31,32)
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337738
PNG
(1-[4-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl]-3-[2-m...)
Show SMILES Cc1nnc(o1)-c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H17F3N4O5/c1-12-15(4-3-5-18(12)23(24,25)26)10-30-20(31)17(21(32)33)11-29(22(30)34)16-8-6-14(7-9-16)19-28-27-13(2)35-19/h3-9,11H,10H2,1-2H3,(H,32,33)
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337721
PNG
(Ethyl 1-[4-(5-amino-1,3,4-oxadiazol-2-yl)phenyl]-3...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)-c2nnc(N)o2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C23H17ClF3N5O5/c1-2-36-20(34)15-11-31(14-8-6-12(7-9-14)18-29-30-21(28)37-18)22(35)32(19(15)33)10-13-4-3-5-16(17(13)24)23(25,26)27/h3-9,11H,2,10H2,1H3,(H2,28,30)
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337736
PNG
(1-[4-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl]-3-[2-c...)
Show SMILES Cc1nnc(o1)-c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H14ClF3N4O5/c1-11-27-28-18(35-11)12-5-7-14(8-6-12)29-10-15(20(32)33)19(31)30(21(29)34)9-13-3-2-4-16(17(13)23)22(24,25)26/h2-8,10H,9H2,1H3,(H,32,33)
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337726
PNG
(Ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-d...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)-c2noc(=O)[nH]2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
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US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337728
PNG
(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Show SMILES Cc1c(Cn2c(=O)c(cn(-c3ccc(cc3)-c3noc(=O)[nH]3)c2=O)C(O)=O)cccc1C(F)(F)F
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n/an/a 1.70E+3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337751
PNG
(Ethyl 1-[4-(4,4-dimethyl-2-oxoimidazolidin-1-yl)ph...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)N2CC(C)(C)NC2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Show InChI InChI=1S/C26H24F4N4O5/c1-4-39-22(36)18-13-32(16-8-10-17(11-9-16)34-14-25(2,3)31-23(34)37)24(38)33(21(18)35)12-15-6-5-7-19(27)20(15)26(28,29)30/h5-11,13H,4,12,14H2,1-3H3,(H,31,37)
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337724
PNG
(Ethyl 1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)-c2nnc(C)o2)c(=O)n(Cc2cccc(c2Cl)C(F)(F)F)c1=O
Show InChI InChI=1S/C24H18ClF3N4O5/c1-3-36-22(34)17-12-31(16-9-7-14(8-10-16)20-30-29-13(2)37-20)23(35)32(21(17)33)11-15-5-4-6-18(19(15)25)24(26,27)28/h4-10,12H,3,11H2,1-2H3
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337723
PNG
(Ethyl 1-[4-(5-amino-1,3,4-oxadiazol-2-yl)phenyl]-3...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)-c2nnc(N)o2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O
Show InChI InChI=1S/C22H17Cl2N5O5/c1-2-33-20(31)15-11-28(14-8-6-12(7-9-14)18-26-27-21(25)34-18)22(32)29(19(15)30)10-13-4-3-5-16(23)17(13)24/h3-9,11H,2,10H2,1H3,(H2,25,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM337725
PNG
(Ethyl 1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-...)
Show SMILES CCOC(=O)c1cn(-c2ccc(cc2)-c2nnc(C)o2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O
Show InChI InChI=1S/C25H21F3N4O5/c1-4-36-23(34)19-13-31(18-10-8-16(9-11-18)21-30-29-15(3)37-21)24(35)32(22(19)33)12-17-6-5-7-20(14(17)2)25(26,27)28/h5-11,13H,4,12H2,1-3H3
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...


US Patent US9751843 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%