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Patent code US9751850

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337806
PNG
((1E,3E)-1-(6-fluoropyridin-3-yl)-2-methylpent-1-en...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1ccc(F)nc1
Show InChI InChI=1S/C11H13FN2O/c1-3-10(14-15)8(2)6-9-4-5-11(12)13-7-9/h4-7,15H,3H2,1-2H3/b8-6+,14-10+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.25E+3n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337809
PNG
((1E,3E)-2-methyl-1-thien-3-ylpent-1-en-3-one oxime...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1ccsc1
Show InChI InChI=1S/C10H13NOS/c1-3-10(11-12)8(2)6-9-4-5-13-7-9/h4-7,12H,3H2,1-2H3/b8-6+,11-10+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.32E+3n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337811
PNG
((1E,3E)-2-methyl-1-pyridin-4-ylpent-1-en-3-one oxi...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1ccncc1
Show InChI InChI=1S/C11H14N2O/c1-3-11(13-14)9(2)8-10-4-6-12-7-5-10/h4-8,14H,3H2,1-2H3/b9-8+,13-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.61E+3n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337807
PNG
((1E,3E)-2-methyl-1-thien-2-ylpent-1-en-3-one oxime...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1cccs1
Show InChI InChI=1S/C10H13NOS/c1-3-10(11-12)8(2)7-9-5-4-6-13-9/h4-7,12H,3H2,1-2H3/b8-7+,11-10+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+4n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337810
PNG
((1E,3E)-2-methyl-1-pyridin-3-ylpent-1-en-3-one oxi...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1cccnc1
Show InChI InChI=1S/C11H14N2O/c1-3-11(13-14)9(2)7-10-5-4-6-12-8-10/h4-8,14H,3H2,1-2H3/b9-7+,13-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70E+4n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337808
PNG
((1E,3E)-1-(6-methoxypyridin-3-yl)-2-methylpent-1-e...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1ccc(OC)nc1
Show InChI InChI=1S/C12H16N2O2/c1-4-11(14-15)9(2)7-10-5-6-12(16-3)13-8-10/h5-8,15H,4H2,1-3H3/b9-7+,14-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.34E+4n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337815
PNG
((1E,3E)-2-methyl-1-[6-(trifluoromethyl)pyridin-3-y...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C12H13F3N2O/c1-3-10(17-18)8(2)6-9-4-5-11(16-7-9)12(13,14)15/h4-7,18H,3H2,1-2H3/b8-6+,17-10+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337813
PNG
((1E,3E)-2-methyl-1-quinolin-3-ylpent-1-en-3-one ox...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1cnc2ccccc2c1
Show InChI InChI=1S/C15H16N2O/c1-3-14(17-18)11(2)8-12-9-13-6-4-5-7-15(13)16-10-12/h4-10,18H,3H2,1-2H3/b11-8+,17-14+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337816
PNG
((1E,3E)-1-(isoquinolin-4-yl)-2-methylpent-1-en-3-o...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1cncc2ccccc12
Show InChI InChI=1S/C15H16N2O/c1-3-15(17-18)11(2)8-13-10-16-9-12-6-4-5-7-14(12)13/h4-10,18H,3H2,1-2H3/b11-8+,17-15+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337814
PNG
((1E,3E)-2-methyl-1-(4-methylpyridin-3-yl)pent-1-en...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1cnccc1C
Show InChI InChI=1S/C12H16N2O/c1-4-12(14-15)10(3)7-11-8-13-6-5-9(11)2/h5-8,15H,4H2,1-3H3/b10-7+,14-12+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM337812
PNG
((1E,3E)-2-methyl-1-(6-methylpyridin-3-yl)pent-1-en...)
Show SMILES CC\C(=N/O)\C(\C)=C\c1ccc(C)nc1
Show InChI InChI=1S/C12H16N2O/c1-4-12(14-15)9(2)7-11-6-5-10(3)13-8-11/h5-8,15H,4H2,1-3H3/b9-7+,14-12+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



ABBVIE INC.

US Patent


Assay Description
Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...


US Patent US9751850 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%