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Patent code US9751886

Compile Data Set for Download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))
BDBM338839
PNG
(US9751886, Compound 4)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C18H15ClFN7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1
PDB
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n/an/a 1.74n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338837
PNG
(US9751886, Compound 2)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C19H15FN8O/c1-19(10-28-16(9-24-27-28)17(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8-9H,10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1
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n/an/a 1.78n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338837
PNG
(US9751886, Compound 2)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C19H15FN8O/c1-19(10-28-16(9-24-27-28)17(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8-9H,10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338839
PNG
(US9751886, Compound 4)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C18H15ClFN7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338840
PNG
(N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]tria...)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F
Show InChI InChI=1S/C17H14ClF3N8O/c1-17(7-29-12(5-23-27-29)14(22)25-17)9-4-8(2-3-11(9)19)24-15(30)13-10(18)6-28(26-13)16(20)21/h2-6,16H,7H2,1H3,(H2,22,25)(H,24,30)/t17-/m0/s1
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n/an/a 1.86n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338840
PNG
(N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]tria...)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F
Show InChI InChI=1S/C17H14ClF3N8O/c1-17(7-29-12(5-23-27-29)14(22)25-17)9-4-8(2-3-11(9)19)24-15(30)13-10(18)6-28(26-13)16(20)21/h2-6,16H,7H2,1H3,(H2,22,25)(H,24,30)/t17-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338838
PNG
(US9751886, Compound 3)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)Cn2nncc2C(N)=N1
Show InChI InChI=1S/C18H17FN8O2/c1-18(9-27-14(7-23-26-27)16(20)25-18)11-5-10(3-4-12(11)19)24-17(28)13-6-22-15(29-2)8-21-13/h3-8H,9H2,1-2H3,(H2,20,25)(H,24,28)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338838
PNG
(US9751886, Compound 3)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)Cn2nncc2C(N)=N1
Show InChI InChI=1S/C18H17FN8O2/c1-18(9-27-14(7-23-26-27)16(20)25-18)11-5-10(3-4-12(11)19)24-17(28)13-6-22-15(29-2)8-21-13/h3-8H,9H2,1-2H3,(H2,20,25)(H,24,28)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338839
PNG
(US9751886, Compound 4)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C18H15ClFN7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1
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n/an/a 2.75n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338843
PNG
(N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]tria...)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)cc(F)c1F
Show InChI InChI=1S/C18H14F3N7O/c1-18(8-28-14(7-24-27-28)16(22)26-18)11-4-10(5-12(20)15(11)21)25-17(29)13-3-2-9(19)6-23-13/h2-7H,8H2,1H3,(H2,22,26)(H,25,29)/t18-/m0/s1
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n/an/a 3.02n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338842
PNG
(US9751886, Compound 7)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F
Show InChI InChI=1S/C19H17F2N7O2/c1-19(9-28-16(8-24-27-28)17(22)26-19)13-6-11(2-4-14(13)21)25-18(29)15-5-3-12(7-23-15)30-10-20/h2-8H,9-10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1
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n/an/a 3.02n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338841
PNG
(US9751886, Compound 6)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F
Show InChI InChI=1S/C19H16F4N8O2/c1-18(8-31-14(6-27-30-31)16(24)29-18)11-4-10(2-3-12(11)20)28-17(32)13-5-26-15(7-25-13)33-9-19(21,22)23/h2-7H,8-9H2,1H3,(H2,24,29)(H,28,32)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338844
PNG
(US9751886, Compound 10 | US9751886, Compound 9)
Show SMILES NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1
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n/an/a 3.24n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338836
PNG
(US9751886, Compound 1)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H15F2N7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1
PDB

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n/an/a 3.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338844
PNG
(US9751886, Compound 10 | US9751886, Compound 9)
Show SMILES NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1
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n/an/a 4.07n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338836
PNG
(US9751886, Compound 1)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H15F2N7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338843
PNG
(N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]tria...)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)cc(F)c1F
Show InChI InChI=1S/C18H14F3N7O/c1-18(8-28-14(7-24-27-28)16(22)26-18)11-4-10(5-12(20)15(11)21)25-17(29)13-3-2-9(19)6-23-13/h2-7H,8H2,1H3,(H2,22,26)(H,25,29)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338836
PNG
(US9751886, Compound 1)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H15F2N7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338837
PNG
(US9751886, Compound 2)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C19H15FN8O/c1-19(10-28-16(9-24-27-28)17(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8-9H,10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1
PDB

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n/an/a 5.37n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338844
PNG
(US9751886, Compound 10 | US9751886, Compound 9)
Show SMILES NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1
PDB
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n/an/a 8.32n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338844
PNG
(US9751886, Compound 10 | US9751886, Compound 9)
Show SMILES NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1
PDB

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UniChem
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n/an/a 8.32n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338838
PNG
(US9751886, Compound 3)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)Cn2nncc2C(N)=N1
Show InChI InChI=1S/C18H17FN8O2/c1-18(9-27-14(7-23-26-27)16(20)25-18)11-5-10(3-4-12(11)19)24-17(28)13-6-22-15(29-2)8-21-13/h3-8H,9H2,1-2H3,(H2,20,25)(H,24,28)/t18-/m0/s1
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n/an/a 15.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338842
PNG
(US9751886, Compound 7)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F
Show InChI InChI=1S/C19H17F2N7O2/c1-19(9-28-16(8-24-27-28)17(22)26-19)13-6-11(2-4-14(13)21)25-18(29)15-5-3-12(7-23-15)30-10-20/h2-8H,9-10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1
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n/an/a 16.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338841
PNG
(US9751886, Compound 6)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F
Show InChI InChI=1S/C19H16F4N8O2/c1-18(8-31-14(6-27-30-31)16(24)29-18)11-4-10(2-3-12(11)20)28-17(32)13-5-26-15(7-25-13)33-9-19(21,22)23/h2-7H,8-9H2,1H3,(H2,24,29)(H,28,32)/t18-/m0/s1
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n/an/a 60.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM338846
PNG
((rac)-N-{3-[4-amino-6-(fluoromethyl)-6,7-dihydro[1...)
Show SMILES NC1=N[C@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ┐Swedish┐ Lys-Met/Asn-Leu ...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338846
PNG
((rac)-N-{3-[4-amino-6-(fluoromethyl)-6,7-dihydro[1...)
Show SMILES NC1=N[C@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338844
PNG
(US9751886, Compound 10 | US9751886, Compound 9)
Show SMILES NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338844
PNG
(US9751886, Compound 10 | US9751886, Compound 9)
Show SMILES NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338846
PNG
((rac)-N-{3-[4-amino-6-(fluoromethyl)-6,7-dihydro[1...)
Show SMILES NC1=N[C@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338841
PNG
(US9751886, Compound 6)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F
Show InChI InChI=1S/C19H16F4N8O2/c1-18(8-31-14(6-27-30-31)16(24)29-18)11-4-10(2-3-12(11)20)28-17(32)13-5-26-15(7-25-13)33-9-19(21,22)23/h2-7H,8-9H2,1H3,(H2,24,29)(H,28,32)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338843
PNG
(N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]tria...)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)cc(F)c1F
Show InChI InChI=1S/C18H14F3N7O/c1-18(8-28-14(7-24-27-28)16(22)26-18)11-4-10(5-12(20)15(11)21)25-17(29)13-3-2-9(19)6-23-13/h2-7H,8H2,1H3,(H2,22,26)(H,25,29)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338840
PNG
(N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]tria...)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F
Show InChI InChI=1S/C17H14ClF3N8O/c1-17(7-29-12(5-23-27-29)14(22)25-17)9-4-8(2-3-11(9)19)24-15(30)13-10(18)6-28(26-13)16(20)21/h2-6,16H,7H2,1H3,(H2,22,25)(H,24,30)/t17-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM338842
PNG
(US9751886, Compound 7)
Show SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F
Show InChI InChI=1S/C19H17F2N7O2/c1-19(9-28-16(8-24-27-28)17(22)26-19)13-6-11(2-4-14(13)21)25-18(29)15-5-3-12(7-23-15)30-10-20/h2-8H,9-10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...


US Patent US9751886 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%