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Patent code US9757369

Compile Data Set for Download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294083
PNG
(6-Bromo-N′-dodecanoyl-1-ethyl-4-hydroxy-2-ox...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Br)ccc2n(CC)c1=O
Show InChI InChI=1S/C24H34BrN3O4/c1-3-5-6-7-8-9-10-11-12-13-20(29)26-27-23(31)21-22(30)18-16-17(25)14-15-19(18)28(4-2)24(21)32/h14-16,30H,3-13H2,1-2H3,(H,26,29)(H,27,31)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294091
PNG
(7-Chloro-N′-dodecanoyl-1-ethyl-4-hydroxy-2-o...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(CC)c1=O
Show InChI InChI=1S/C24H34ClN3O4/c1-3-5-6-7-8-9-10-11-12-13-20(29)26-27-23(31)21-22(30)18-15-14-17(25)16-19(18)28(4-2)24(21)32/h14-16,30H,3-13H2,1-2H3,(H,26,29)(H,27,31)
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n/an/a 2.48E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM50384798
PNG
(CHEMBL2037482 | US9585879, 6 | US9757369, 6)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(CC)c1=O
Show InChI InChI=1S/C24H35N3O4/c1-3-5-6-7-8-9-10-11-12-17-20(28)25-26-23(30)21-22(29)18-15-13-14-16-19(18)27(4-2)24(21)31/h13-16,29H,3-12,17H2,1-2H3,(H,25,28)(H,26,30)
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US Patent
n/an/a 2.85E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339879
PNG
(7-Chloro-N′-dodecanoyl-4-hydroxy-2-oxo-2-hyd...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2[nH]c1=O
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n/an/a 3.12E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294087
PNG
(6-Chloro-N′-dodecanoyl-1-ethyl-4-hydroxy-2-o...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Cl)ccc2n(CC)c1=O
Show InChI InChI=1S/C24H34ClN3O4/c1-3-5-6-7-8-9-10-11-12-13-20(29)26-27-23(31)21-22(30)18-16-17(25)14-15-19(18)28(4-2)24(21)32/h14-16,30H,3-13H2,1-2H3,(H,26,29)(H,27,31)
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n/an/a 3.18E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339885
PNG
(6-Bromo-N′-dodecanoyl-4-hydroxy-2-oxo-2-hydr...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Br)ccc2[nH]c1=O
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n/an/a 3.54E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339886
PNG
(6-Chloro-N′-dodecanoyl-4-hydroxy-2-oxo-2-hyd...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Cl)ccc2[nH]c1=O
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n/an/a 3.81E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294089
PNG
(7-Chloro-N′-dodecanoyl-4-hydroxy-1-methyl-2-...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(C)c1=O
Show InChI InChI=1S/C23H32ClN3O4/c1-3-4-5-6-7-8-9-10-11-12-19(28)25-26-22(30)20-21(29)17-14-13-16(24)15-18(17)27(2)23(20)31/h13-15,29H,3-12H2,1-2H3,(H,25,28)(H,26,30)
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n/an/a 4.03E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294081
PNG
(6-Bromo-N′-dodecanoyl-4-hydroxy-1-methyl-2-o...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Br)ccc2n(C)c1=O
Show InChI InChI=1S/C23H32BrN3O4/c1-3-4-5-6-7-8-9-10-11-12-19(28)25-26-22(30)20-21(29)17-15-16(24)13-14-18(17)27(2)23(20)31/h13-15,29H,3-12H2,1-2H3,(H,25,28)(H,26,30)
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n/an/a 4.28E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339875
PNG
(N′-Dodecanoyl-4-hydroxy-1-methyl-2-oxo-1,2-d...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(C)c1=O
Show InChI InChI=1S/C23H33N3O4/c1-3-4-5-6-7-8-9-10-11-16-19(27)24-25-22(29)20-21(28)17-14-12-13-15-18(17)26(2)23(20)30/h12-15,28H,3-11,16H2,1-2H3,(H,24,27)(H,25,29)
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n/an/a 4.47E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294090
PNG
(7-Chloro-1-ethyl-4-hydroxy-N′-octanoyl-2-oxo...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(CC)c1=O
Show InChI InChI=1S/C20H26ClN3O4/c1-3-5-6-7-8-9-16(25)22-23-19(27)17-18(26)14-11-10-13(21)12-15(14)24(4-2)20(17)28/h10-12,26H,3-9H2,1-2H3,(H,22,25)(H,23,27)
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n/an/a 4.83E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294076
PNG
(1-(cyclopropylmethyl)-N′-dodecanoyl-4-hydrox...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(CC2CC2)c1=O
Show InChI InChI=1S/C26H37N3O4/c1-2-3-4-5-6-7-8-9-10-15-22(30)27-28-25(32)23-24(31)20-13-11-12-14-21(20)29(26(23)33)18-19-16-17-19/h11-14,19,31H,2-10,15-18H2,1H3,(H,27,30)(H,28,32)
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n/an/a 5.25E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294077
PNG
(1-Benzyl-N′-dodecanoyl-4-hydroxy-2-oxo-1,2-d...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C29H37N3O4/c1-2-3-4-5-6-7-8-9-13-20-25(33)30-31-28(35)26-27(34)23-18-14-15-19-24(23)32(29(26)36)21-22-16-11-10-12-17-22/h10-12,14-19,34H,2-9,13,20-21H2,1H3,(H,30,33)(H,31,35)
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n/an/a 5.51E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339880
PNG
(6-Fluoro-N′-dodecanoyl-4-hydroxy-2-oxo-2-hyd...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(F)ccc2[nH]c1=O
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n/an/a 5.81E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294085
PNG
(6-Chloro-N′-dodecanoyl-4-hydroxy-1-methyl-2-...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Cl)ccc2n(C)c1=O
Show InChI InChI=1S/C23H32ClN3O4/c1-3-4-5-6-7-8-9-10-11-12-19(28)25-26-22(30)20-21(29)17-15-16(24)13-14-18(17)27(2)23(20)31/h13-15,29H,3-12H2,1-2H3,(H,25,28)(H,26,30)
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n/an/a 5.95E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294092
PNG
(1-Benzyl-7-chloro-4-hydroxy-N′-octanoyl-2-ox...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C25H28ClN3O4/c1-2-3-4-5-9-12-21(30)27-28-24(32)22-23(31)19-14-13-18(26)15-20(19)29(25(22)33)16-17-10-7-6-8-11-17/h6-8,10-11,13-15,31H,2-5,9,12,16H2,1H3,(H,27,30)(H,28,32)
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n/an/a 5.96E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294093
PNG
(1-Benzyl-7-chloro-N′dodecanoyl-4-hydroxy-2-o...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C29H36ClN3O4/c1-2-3-4-5-6-7-8-9-13-16-25(34)31-32-28(36)26-27(35)23-18-17-22(30)19-24(23)33(29(26)37)20-21-14-11-10-12-15-21/h10-12,14-15,17-19,35H,2-9,13,16,20H2,1H3,(H,31,34)(H,32,36)
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n/an/a 5.99E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294080
PNG
(6-Bromo-4-hydroxy-1-methyl-N′-octanoyl-2-oxo...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Br)ccc2n(C)c1=O
Show InChI InChI=1S/C19H24BrN3O4/c1-3-4-5-6-7-8-15(24)21-22-18(26)16-17(25)13-11-12(20)9-10-14(13)23(2)19(16)27/h9-11,25H,3-8H2,1-2H3,(H,21,24)(H,22,26)
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n/an/a 6.28E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294088
PNG
(7-Chloro-4-hydroxy-1-methyl-N′-octanoyl-2-ox...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2n(C)c1=O
Show InChI InChI=1S/C19H24ClN3O4/c1-3-4-5-6-7-8-15(24)21-22-18(26)16-17(25)13-10-9-12(20)11-14(13)23(2)19(16)27/h9-11,25H,3-8H2,1-2H3,(H,21,24)(H,22,26)
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n/an/a 6.66E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294094
PNG
(N′,1-Dibenzyl-N′-dodecanoyl-4-hydroxy-...)
Show SMILES CCCCCCCCCCCC(=O)N(Cc1ccccc1)NC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C36H43N3O4/c1-2-3-4-5-6-7-8-9-16-25-32(40)39(27-29-21-14-11-15-22-29)37-35(42)33-34(41)30-23-17-18-24-31(30)38(36(33)43)26-28-19-12-10-13-20-28/h10-15,17-24,41H,2-9,16,25-27H2,1H3,(H,37,42)
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Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294074
PNG
(4-Hydroxy-1-(isoprenyl)-N′-octanoyl-2-oxo-1,...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(C=CC(C)=C)c1=O
Show InChI InChI=1S/C23H29N3O4/c1-4-5-6-7-8-13-19(27)24-25-22(29)20-21(28)17-11-9-10-12-18(17)26(23(20)30)15-14-16(2)3/h9-12,14-15,28H,2,4-8,13H2,1,3H3,(H,24,27)(H,25,29)
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n/an/a 7.11E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294082
PNG
(6-Bromo-1-ethyl-4-hydroxy-N′-octanoyl-2-oxo-...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Br)ccc2n(CC)c1=O
Show InChI InChI=1S/C20H26BrN3O4/c1-3-5-6-7-8-9-16(25)22-23-19(27)17-18(26)14-12-13(21)10-11-15(14)24(4-2)20(17)28/h10-12,26H,3-9H2,1-2H3,(H,22,25)(H,23,27)
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n/an/a 7.34E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339875
PNG
(N′-Dodecanoyl-4-hydroxy-1-methyl-2-oxo-1,2-d...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(C)c1=O
Show InChI InChI=1S/C23H33N3O4/c1-3-4-5-6-7-8-9-10-11-16-19(27)24-25-22(29)20-21(28)17-14-12-13-15-18(17)26(2)23(20)30/h12-15,28H,3-11,16H2,1-2H3,(H,24,27)(H,25,29)
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n/an/a 7.35E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294075
PNG
(N′-Dodecanoyl-4-hydroxy-1-(isoprenyl)-2-oxo-...)
Show SMILES CCCCCCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(C=CC(C)=C)c1=O
Show InChI InChI=1S/C27H37N3O4/c1-4-5-6-7-8-9-10-11-12-17-23(31)28-29-26(33)24-25(32)21-15-13-14-16-22(21)30(27(24)34)19-18-20(2)3/h13-16,18-19,32H,2,4-12,17H2,1,3H3,(H,28,31)(H,29,33)
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n/an/a 7.78E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294084
PNG
(6-Chloro-4-hydroxy-1-methyl-N′-octanoyl-2-ox...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Cl)ccc2n(C)c1=O
Show InChI InChI=1S/C19H24ClN3O4/c1-3-4-5-6-7-8-15(24)21-22-18(26)16-17(25)13-11-12(20)9-10-14(13)23(2)19(16)27/h9-11,25H,3-8H2,1-2H3,(H,21,24)(H,22,26)
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n/an/a 8.48E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294067
PNG
(4-Hydroxy-1-methyl-N′-octanoyl-2-oxo-1,2-dih...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(C)c1=O
Show InChI InChI=1S/C19H25N3O4/c1-3-4-5-6-7-12-15(23)20-21-18(25)16-17(24)13-10-8-9-11-14(13)22(2)19(16)26/h8-11,24H,3-7,12H2,1-2H3,(H,20,23)(H,21,25)
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n/an/a 8.67E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM339878
PNG
(7-Chloro-4-hydroxy-N′-octanoyl-2-oxo-2-hydro...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2ccc(Cl)cc2[nH]c1=O
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n/an/a 9.00E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta (GSK3B)


(Homo sapiens (Human))
BDBM294086
PNG
(6-Chloro-1-ethyl-4-hydroxy-N′-octanoyl-2-oxo...)
Show SMILES CCCCCCCC(=O)NNC(=O)c1c(O)c2cc(Cl)ccc2n(CC)c1=O
Show InChI InChI=1S/C20H26ClN3O4/c1-3-5-6-7-8-9-16(25)22-23-19(27)17-18(26)14-12-13(21)10-11-15(14)24(4-2)20(17)28/h10-12,26H,3-9H2,1-2H3,(H,22,25)(H,23,27)
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n/an/a 9.42E+3n/an/an/an/an/an/a



Consejo Superior de Investigaciones Cientificas (CSIC)

US Patent


Assay Description
The enzyme inhibition assays were performed using the luminometric methodology of Kinase-GloŽ. The recombinant human GSK3 enzyme (catalogue no. 14-30...


US Patent US9757369 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%