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Patent code US9758483

Compile Data Set for Download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161329
PNG
(US10087143, Compound 114 | US9051270, 114 | US9163...)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-17-6-10(22)2-3-15(17)28-16-9-14(21)13(20)8-12(16)19(26)24-11-4-5-23-18(25)7-11/h2-9H,1H3,(H2,23,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161373
PNG
(US10087143, Compound 158 | US9051270, 158 | US9758...)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-9-12(21)3-5-15(17)30-16-8-11(20(22,23)24)2-4-14(16)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 2n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161326
PNG
(US10087143, Compound 111 | US9051270, 111 | US9163...)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C21H14F6N2O4/c1-32-17-9-12(22)3-5-15(17)33-16-8-11(20(23,24)21(25,26)27)2-4-14(16)19(31)29-13-6-7-28-18(30)10-13/h2-10H,1H3,(H2,28,29,30,31)
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n/an/a 3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161369
PNG
(US10087143, Compound 154 | US9051270, 154 | US9758...)
Show SMILES COc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H13F7N2O4/c1-33-15-8-11(22)2-3-14(15)34-16-7-10(20(23,24)25)6-13(21(26,27)28)18(16)19(32)30-12-4-5-29-17(31)9-12/h2-9H,1H3,(H2,29,30,31,32)
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n/an/a 5n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161328
PNG
(US10087143, Compound 113 | US9051270, 113 | US9163...)
Show SMILES Fc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-14-8-13(18(25)23-11-5-6-22-17(24)7-11)16(9-15(14)20)26-12-3-1-10(21)2-4-12/h1-9H,(H2,22,23,24,25)
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n/an/a 6n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161330
PNG
(US10087143, Compound 115 | US9051270, 115 | US9758...)
Show SMILES COc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1F
Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-16-3-2-11(7-15(16)22)28-17-9-14(21)13(20)8-12(17)19(26)24-10-4-5-23-18(25)6-10/h2-9H,1H3,(H2,23,24,25,26)
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n/an/a 7n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161368
PNG
(US10087143, Compound 153 | US9051270, 153 | US9758...)
Show SMILES Cc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H13F7N2O3/c1-10-6-12(22)2-3-15(10)33-16-8-11(20(23,24)25)7-14(21(26,27)28)18(16)19(32)30-13-4-5-29-17(31)9-13/h2-9H,1H3,(H2,29,30,31,32)
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n/an/a 10n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161245
PNG
(US10087143, Compound 30 | US9051270, 30 | US916304...)
Show SMILES COc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-9-12(21)3-5-16(17)30-15-4-2-11(20(22,23)24)8-14(15)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 11n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161294
PNG
(US9051270, 79 | US9051270, 82 | US9163042, 5a | US...)
Show SMILES FC(F)(F)Oc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-15(18(30)28-12-7-8-27-17(29)10-12)16(9-11)31-13-2-4-14(5-3-13)32-20(24,25)26/h1-10H,(H2,27,28,29,30)
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n/an/a 11n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161370
PNG
(US10087143, Compound 155 | US9051270, 155 | US9758...)
Show SMILES Fc1ccc(Oc2cc(cc(c2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C20H11F7N2O3/c21-11-1-3-13(4-2-11)32-15-8-10(19(22,23)24)7-14(20(25,26)27)17(15)18(31)29-12-5-6-28-16(30)9-12/h1-9H,(H2,28,29,30,31)
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n/an/a 11n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161303
PNG
(US10087143, Compound 88 | US9051270, 88 | US916304...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O3/c21-12-2-4-14(5-3-12)31-16-9-11(19(22,23)20(24,25)26)1-6-15(16)18(30)28-13-7-8-27-17(29)10-13/h1-10H,(H2,27,28,29,30)
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n/an/a 12n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161287
PNG
(US10087143, Compound 72 | US9051270, 72 | US905127...)
Show SMILES FC(F)(F)Oc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-16(31-13-2-4-14(5-3-13)32-20(24,25)26)15(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)
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n/an/a 13n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161285
PNG
(US9051270, 70 | US9163042, 7a | US9758483, Compoun...)
Show SMILES COc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-16(17)27-15-4-2-11(20)8-14(15)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 13n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161225
PNG
(US10087143, Compound 10 | US9051270, 10 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-9-12(20(22,23)24)2-4-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 14n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161231
PNG
(US10087143, Compound 16 | US9051270, 16 | US975848...)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-15(17)27-16-8-11(20)2-4-14(16)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 14n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161304
PNG
(US10087143, Compound 89 | US9051270, 89 | US975848...)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)C(F)(F)F)cc1F
Show InChI InChI=1S/C21H14F6N2O4/c1-32-16-5-3-13(10-15(16)22)33-17-8-11(20(23,24)21(25,26)27)2-4-14(17)19(31)29-12-6-7-28-18(30)9-12/h2-10H,1H3,(H2,28,29,30,31)
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n/an/a 16n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161327
PNG
(BDBM288026 | US9051270, 112 | US9758483, Compound ...)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C21H14F6N2O3/c1-11-8-13(22)3-5-16(11)32-17-9-12(20(23,24)21(25,26)27)2-4-15(17)19(31)29-14-6-7-28-18(30)10-14/h2-10H,1H3,(H2,28,29,30,31)
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n/an/a 16n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161246
PNG
(US10087143, Compound 106 | US9051270, 106 | US9051...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 17n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM339990
PNG
(US9758483, Compound 63)
Show SMILES Cc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(C)c1
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n/an/a 18n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161265
PNG
(US10087143, Compound 50 | US9051270, 50 | US975848...)
Show SMILES Cc1cc(Cl)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 19n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161324
PNG
(US10087143, Compound 109 | US9051270, 109 | US9758...)
Show SMILES Fc1ccc(Oc2cc(Cl)c(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H10Cl2F2N2O3/c19-12-8-16(27-15-2-1-9(21)5-13(15)20)11(7-14(12)22)18(26)24-10-3-4-23-17(25)6-10/h1-8H,(H2,23,24,25,26)
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n/an/a 19n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161259
PNG
(US10087143, Compound 44 | US9051270, 44 | US975848...)
Show SMILES CCOc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H17F3N2O4/c1-2-29-15-4-6-16(7-5-15)30-18-8-3-13(21(22,23)24)11-17(18)20(28)26-14-9-10-25-19(27)12-14/h3-12H,2H2,1H3,(H2,25,26,27,28)
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n/an/a 20n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161264
PNG
(US9051270, 49 | US9758483, Compound 49)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H14ClF3N2O4/c1-29-13-3-5-17(15(21)10-13)30-16-4-2-11(20(22,23)24)8-14(16)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 24n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161305
PNG
(US10087143, Compound 90 | US9051270, 90 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C19H10F6N2O3/c20-12-2-4-14(17(22)16(12)21)30-13-3-1-9(19(23,24)25)7-11(13)18(29)27-10-5-6-26-15(28)8-10/h1-8H,(H2,26,27,28,29)
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n/an/a 26n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161296
PNG
(US10087143, Compound 81 | US9051270, 81 | US975848...)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-16-5-3-13(10-15(16)21)30-17-8-11(20(22,23)24)2-4-14(17)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 26n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161302
PNG
(US10087143, Compound 87 | US9051270, 87 | US975848...)
Show SMILES COc1c(F)cccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-18-14(21)3-2-4-15(18)30-16-9-11(20(22,23)24)5-6-13(16)19(28)26-12-7-8-25-17(27)10-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 27n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161244
PNG
(US10087143, Compound 29 | US9051270, 29 | US916304...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N2O3/c20-14-8-11(21)2-4-16(14)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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n/an/a 28n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161292
PNG
(US10087143, Compound 77 | US9051270, 77 | US975848...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N2O3/c20-14-8-11(21)2-4-15(14)29-16-7-10(19(22,23)24)1-3-13(16)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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n/an/a 29n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161235
PNG
(US10087143, Compound 20 | US9051270, 20 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-9-12(20)2-4-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 30n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161283
PNG
(US10087143, Compound 68 | US9051270, 68 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 30n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161269
PNG
(US10087143, Compound 54 | US9051270, 54 | US975848...)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-18-14(21)3-2-4-16(18)30-15-6-5-11(20(22,23)24)9-13(15)19(28)26-12-7-8-25-17(27)10-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 30n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161293
PNG
(US10087143, Compound 78 | US9051270, 78 | US975848...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H12ClF3N2O3/c20-12-2-4-14(5-3-12)28-16-9-11(19(21,22)23)1-6-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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n/an/a 31n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161274
PNG
(US10087143, Compound 59 | US9051270, 59 | US975848...)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-5-3-13(10-15(17)21)30-16-4-2-11(20(22,23)24)8-14(16)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 32n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161277
PNG
(US10087143, Compound 62 | US9051270, 62 | US975848...)
Show SMILES CCCOc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N2O4/c1-2-11-30-18-5-3-4-6-19(18)31-17-8-7-14(22(23,24)25)12-16(17)21(29)27-15-9-10-26-20(28)13-15/h3-10,12-13H,2,11H2,1H3,(H2,26,27,28,29)
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n/an/a 34n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287987
PNG
(US10087143, Compound 73 | US9758483, Compound 73)
Show SMILES FC(F)Oc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H13F5N2O4/c21-19(22)31-14-4-2-13(3-5-14)30-16-6-1-11(20(23,24)25)9-15(16)18(29)27-12-7-8-26-17(28)10-12/h1-10,19H,(H2,26,27,28,29)
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n/an/a 35n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287996
PNG
(US10087143, Compound 82 | US9758483, Compound 82)
Show SMILES FC(F)Oc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H13F5N2O4/c21-19(22)31-14-4-2-13(3-5-14)30-16-9-11(20(23,24)25)1-6-15(16)18(29)27-12-7-8-26-17(28)10-12/h1-10,19H,(H2,26,27,28,29)
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n/an/a 36n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161281
PNG
(US10087143, Compound 66 | US9051270, 66 | US916304...)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-15(26-16-4-2-11(21)8-14(16)20)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)
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n/an/a 37n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161220
PNG
(US10087143, Compound 5 | US9051270, 5 | US9758483,...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-4-14(5-3-12)28-16-9-11(19(21,22)23)1-6-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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n/an/a 39n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161255
PNG
(US10087143, Compound 40 | US9051270, 40 | US975848...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-11-8-12(21)2-4-16(11)29-17-5-3-14(30-20(22,23)24)10-15(17)19(28)26-13-6-7-25-18(27)9-13/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 40n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161243
PNG
(US10087143, Compound 28 | US9051270, 28 | US916304...)
Show SMILES Cc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N2O3/c1-12-4-2-3-5-16(12)28-17-7-6-13(20(21,22)23)10-15(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161367
PNG
(US10087143, Compound 152 | US9051270, 152 | US9758...)
Show SMILES Fc1ccc(Oc2cc(cc(c2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H10F8N2O3/c21-10-1-2-14(13(22)7-10)33-15-6-9(19(23,24)25)5-12(20(26,27)28)17(15)18(32)30-11-3-4-29-16(31)8-11/h1-8H,(H2,29,30,31,32)
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n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161298
PNG
(US10087143, Compound 83 | US9051270, 83 | US975848...)
Show SMILES FC(F)Oc1ccccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H13F5N2O4/c21-19(22)31-15-4-2-1-3-14(15)30-16-9-11(20(23,24)25)5-6-13(16)18(29)27-12-7-8-26-17(28)10-12/h1-10,19H,(H2,26,27,28,29)
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n/an/a 46n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161299
PNG
(US10087143, Compound 84 | US9051270, 84 | US975848...)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-29-13-3-5-16(15(21)10-13)30-17-8-11(20(22,23)24)2-4-14(17)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 46n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161268
PNG
(US10087143, Compound 53 | US9051270, 53 | US975848...)
Show SMILES CCCOc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H19F3N2O4/c1-2-11-30-16-4-6-17(7-5-16)31-19-8-3-14(22(23,24)25)12-18(19)21(29)27-15-9-10-26-20(28)13-15/h3-10,12-13H,2,11H2,1H3,(H2,26,27,28,29)
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n/an/a 47n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161222
PNG
(US10087143, Compound 7 | US9051270, 7 | US9163042,...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H11F5N2O3/c20-11-2-4-15(14(21)8-11)29-16-7-10(19(22,23)24)1-3-13(16)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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n/an/a 50n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161290
PNG
(US10087143, Compound 75 | US9051270, 75 | US916304...)
Show SMILES FC(F)(F)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-5-6-14(31-15-3-1-2-4-16(15)32-20(24,25)26)13(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)
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n/an/a 51n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161252
PNG
(US10087143, Compound 37 | US9051270, 37 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N2O4/c20-14-7-10(21)1-3-16(14)29-15-4-2-12(30-19(22,23)24)9-13(15)18(28)26-11-5-6-25-17(27)8-11/h1-9H,(H2,25,26,27,28)
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n/an/a 51n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161371
PNG
(US10087143, Compound 156 | US9051270, 156 | US9758...)
Show SMILES FC(F)(F)c1cc(Oc2ccccc2)c(C(=O)Nc2cc[nH]c(=O)c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O3/c21-19(22,23)11-8-14(20(24,25)26)17(15(9-11)31-13-4-2-1-3-5-13)18(30)28-12-6-7-27-16(29)10-12/h1-10H,(H2,27,28,29,30)
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n/an/a 52n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161217
PNG
(US10087143, Compound 2 | US9051270, 2 | US9163042,...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-4-14(5-3-12)28-16-6-1-11(19(21,22)23)9-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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n/an/a 54n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161273
PNG
(US10087143, Compound 58 | US9051270, 58 | US975848...)
Show SMILES FC(F)(F)c1ccc(Oc2ccc(Cl)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H12ClF3N2O3/c20-12-2-4-14(5-3-12)28-16-6-1-11(19(21,22)23)9-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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n/an/a 54n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161291
PNG
(US10087143, Compound 76 | US9051270, 76 | US975848...)
Show SMILES FC(F)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H13F5N2O4/c21-19(22)31-16-4-2-1-3-15(16)30-14-6-5-11(20(23,24)25)9-13(14)18(29)27-12-7-8-26-17(28)10-12/h1-10,19H,(H2,26,27,28,29)
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n/an/a 54n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161226
PNG
(US10087143, Compound 11 | US9051270, 11 | US975848...)
Show SMILES Cc1ccccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N2O3/c1-12-4-2-3-5-16(12)28-17-10-13(20(21,22)23)6-7-15(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 56n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161372
PNG
(US10087143, Compound 157 | US9051270, 157 | US9758...)
Show SMILES OCc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c21-13-2-4-16(11(7-13)10-27)30-17-8-12(20(22,23)24)1-3-15(17)19(29)26-14-5-6-25-18(28)9-14/h1-9,27H,10H2,(H2,25,26,28,29)
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n/an/a 58n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161239
PNG
(US10087143, Compound 24 | US9051270, 24 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H11F5N2O3/c20-11-2-4-16(14(21)8-11)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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n/an/a 58n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161260
PNG
(US10087143, Compound 45 | US9051270, 45 | US975848...)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N2O4/c1-28-14-3-5-15(6-4-14)29-17-7-2-12(20(21,22)23)10-16(17)19(27)25-13-8-9-24-18(26)11-13/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 64n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161261
PNG
(US10087143, Compound 46 | US9051270, 46 | US975848...)
Show SMILES CCOc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N2O4/c1-2-29-17-5-3-4-6-18(17)30-16-8-7-13(21(22,23)24)11-15(16)20(28)26-14-9-10-25-19(27)12-14/h3-12H,2H2,1H3,(H2,25,26,27,28)
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n/an/a 64n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161229
PNG
(US10087143, Compound 14 | US9051270, 14 | US975848...)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(21)8-14(15)20/h1-9H,(H2,22,23,24,25)
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n/an/a 65n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161257
PNG
(US10087143, Compound 42 | US9051270, 42 | US975848...)
Show SMILES COc1cc(F)ccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O5/c1-29-17-8-11(21)2-4-16(17)30-15-5-3-13(31-20(22,23)24)10-14(15)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 68n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161282
PNG
(US10087143, Compound 67 | US9051270, 67 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-16(25-14-4-2-12(20)3-5-14)15(9-11)18(24)22-13-7-8-21-17(23)10-13/h1-10H,(H2,21,22,23,24)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161271
PNG
(US10087143, Compound 56 | US9051270, 56 | US975848...)
Show SMILES Cc1ccc(F)cc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-2-4-13(21)9-17(11)29-16-5-3-12(20(22,23)24)8-15(16)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161253
PNG
(US10087143, Compound 38 | US9051270, 38 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C19H12F4N2O4/c20-11-1-3-13(4-2-11)28-16-6-5-14(29-19(21,22)23)10-15(16)18(27)25-12-7-8-24-17(26)9-12/h1-10H,(H2,24,25,26,27)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161270
PNG
(US10087143, Compound 55 | US9051270, 55 | US975848...)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-29-13-3-5-17(15(21)10-13)30-16-4-2-11(20(22,23)24)8-14(16)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 70n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161230
PNG
(US10087143, Compound 15 | US9051270, 15 | US975848...)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-15(18(24)22-13-7-8-21-17(23)10-13)16(9-11)25-14-4-2-12(20)3-5-14/h1-10H,(H2,21,22,23,24)
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n/an/a 76n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161356
PNG
(US10087143, Compound 141 | US9051270, 141 | US9758...)
Show SMILES CC(C)(C)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-21(2,3)13-4-6-16(20(30)28-14-8-9-26-19(29)11-14)17(10-13)31-15-5-7-18(27-12-15)22(23,24)25/h4-12H,1-3H3,(H2,26,28,29,30)
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n/an/a 78n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161266
PNG
(US10087143, Compound 51 | US9051270, 51 | US975848...)
Show SMILES Fc1cc(Cl)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H11ClF4N2O3/c20-11-2-4-16(14(21)8-11)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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n/an/a 87n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161286
PNG
(US10087143, Compound 71 | US9051270, 71 | US975848...)
Show SMILES COc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1F
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-5-3-13(10-15(17)21)27-16-4-2-11(20)8-14(16)19(25)23-12-6-7-22-18(24)9-12/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 92n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161224
PNG
(US10087143, Compound 9 | US9051270, 9 | US9758483,...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccccc2)c1
Show InChI InChI=1S/C19H13F3N2O3/c20-19(21,22)12-6-7-15(16(10-12)27-14-4-2-1-3-5-14)18(26)24-13-8-9-23-17(25)11-13/h1-11H,(H2,23,24,25,26)
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n/an/a 93n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161267
PNG
(US10087143, Compound 52 | US9051270, 52 | US975848...)
Show SMILES COc1ccc(F)cc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-16-5-3-12(21)9-17(16)30-15-4-2-11(20(22,23)24)8-14(15)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 94n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161248
PNG
(US10087143, Compound 33 | US9051270, 33 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C19H11F5N2O4/c20-10-1-3-16(14(21)7-10)29-15-4-2-12(30-19(22,23)24)9-13(15)18(28)26-11-5-6-25-17(27)8-11/h1-9H,(H2,25,26,27,28)
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n/an/a 95n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161246
PNG
(US10087143, Compound 106 | US9051270, 106 | US9051...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 99n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161237
PNG
(US10087143, Compound 22 | US9051270, 22 | US975848...)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C#N
Show InChI InChI=1S/C20H14FN3O4/c1-27-18-9-13(21)3-5-16(18)28-17-8-12(11-22)2-4-15(17)20(26)24-14-6-7-23-19(25)10-14/h2-10H,1H3,(H2,23,24,25,26)
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n/an/a 100n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161251
PNG
(US10087143, Compound 36 | US9051270, 36 | US975848...)
Show SMILES Cc1ccccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H15F3N2O4/c1-12-4-2-3-5-16(12)28-17-7-6-14(29-20(21,22)23)11-15(17)19(27)25-13-8-9-24-18(26)10-13/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 101n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161295
PNG
(US10087143, Compound 80 | US9051270, 80 | US975848...)
Show SMILES FC(F)(F)Oc1ccccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-5-6-13(18(30)28-12-7-8-27-17(29)10-12)16(9-11)31-14-3-1-2-4-15(14)32-20(24,25)26/h1-10H,(H2,27,28,29,30)
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n/an/a 105n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161227
PNG
(US10087143, Compound 12 | US9051270, 12 | US975848...)
Show SMILES Cc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N2O3/c1-12-2-5-15(6-3-12)28-17-10-13(20(21,22)23)4-7-16(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 106n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161228
PNG
(US10087143, Compound 13 | US9051270, 13 | US975848...)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(20)8-14(15)21/h1-9H,(H2,22,23,24,25)
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n/an/a 106n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161280
PNG
(US10087143, Compound 65 | US9051270, 65 | US975848...)
Show SMILES FC(F)(F)c1ccc(Oc2ccccc2Cl)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H12ClF3N2O3/c20-14-3-1-2-4-16(14)28-15-6-5-11(19(21,22)23)9-13(15)18(27)25-12-7-8-24-17(26)10-12/h1-10H,(H2,24,25,26,27)
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n/an/a 107n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161279
PNG
(US10087143, Compound 64 | US9051270, 64 | US975848...)
Show SMILES CC(C)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N2O4/c1-13(2)30-18-5-3-4-6-19(18)31-17-8-7-14(22(23,24)25)11-16(17)21(29)27-15-9-10-26-20(28)12-15/h3-13H,1-2H3,(H2,26,27,28,29)
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n/an/a 108n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161284
PNG
(US10087143, Compound 69 | US9051270, 69 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-15(26-16-4-2-11(20)8-14(16)21)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)
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n/an/a 112n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161276
PNG
(US10087143, Compound 61 | US9051270, 61 | US975848...)
Show SMILES Cc1cc(NC(=O)c2cc(ccc2Oc2ccc(F)cc2C)C(F)(F)F)cc(=O)[nH]1
Show InChI InChI=1S/C21H16F4N2O3/c1-11-7-14(22)4-6-17(11)30-18-5-3-13(21(23,24)25)9-16(18)20(29)27-15-8-12(2)26-19(28)10-15/h3-10H,1-2H3,(H2,26,27,28,29)
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n/an/a 113n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161316
PNG
(US10087143, Compound 101 | US9051270, 101 | US9758...)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H12F4N2O4/c20-11-1-6-16(28-13-2-4-14(5-3-13)29-19(21,22)23)15(9-11)18(27)25-12-7-8-24-17(26)10-12/h1-10H,(H2,24,25,26,27)
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n/an/a 120n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161275
PNG
(US10087143, Compound 60 | US9051270, 60 | US975848...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc(Cl)[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H13ClF4N2O3/c1-10-6-12(22)3-5-15(10)30-16-4-2-11(20(23,24)25)7-14(16)19(29)26-13-8-17(21)27-18(28)9-13/h2-9H,1H3,(H2,26,27,28,29)
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n/an/a 126n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161262
PNG
(US10087143, Compound 47 | US9051270, 47 | US975848...)
Show SMILES COc1cc(C)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N2O4/c1-12-3-5-17(18(9-12)29-2)30-16-6-4-13(21(22,23)24)10-15(16)20(28)26-14-7-8-25-19(27)11-14/h3-11H,1-2H3,(H2,25,26,27,28)
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n/an/a 135n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161307
PNG
(US10087143, Compound 92 | US9051270, 92 | US975848...)
Show SMILES Cc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C20H13F5N2O3/c1-10-2-4-15(18(22)17(10)21)30-14-5-3-11(20(23,24)25)8-13(14)19(29)27-12-6-7-26-16(28)9-12/h2-9H,1H3,(H2,26,27,28,29)
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n/an/a 135n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161335
PNG
(US10087143, Compound 120 | US9051270, 120 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OCC2CCCC2)c1
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)13-5-6-15(16(9-13)27-11-12-3-1-2-4-12)18(26)24-14-7-8-23-17(25)10-14/h5-10,12H,1-4,11H2,(H2,23,24,25,26)
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n/an/a 150n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161315
PNG
(US10087143, Compound 100 | US9051270, 100 | US9758...)
Show SMILES CCCOc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C21H19FN2O4/c1-2-11-27-16-4-6-17(7-5-16)28-19-8-3-14(22)12-18(19)21(26)24-15-9-10-23-20(25)13-15/h3-10,12-13H,2,11H2,1H3,(H2,23,24,25,26)
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n/an/a 155n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161247
PNG
(US10087143, Compound 32 | US9051270, 32 | US975848...)
Show SMILES FC(F)(F)c1ccc(Oc2ccccc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13F3N2O3/c20-19(21,22)12-6-7-16(27-14-4-2-1-3-5-14)15(10-12)18(26)24-13-8-9-23-17(25)11-13/h1-11H,(H2,23,24,25,26)
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n/an/a 205n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161221
PNG
(US10087143, Compound 6 | US9051270, 6 | US9758483,...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2ccc(=O)[nH]c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-5-14(6-3-12)28-16-9-11(19(21,22)23)1-7-15(16)18(27)25-13-4-8-17(26)24-10-13/h1-10H,(H,24,26)(H,25,27)
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n/an/a 245n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161256
PNG
(US10087143, Compound 41 | US9051270, 41 | US975848...)
Show SMILES FC(F)(F)Oc1ccc(Oc2ccccc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13F3N2O4/c20-19(21,22)28-14-6-7-16(27-13-4-2-1-3-5-13)15(11-14)18(26)24-12-8-9-23-17(25)10-12/h1-11H,(H2,23,24,25,26)
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n/an/a 260n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161323
PNG
(US10087143, Compound 108 | US9051270, 108 | US9758...)
Show SMILES Fc1ccc(Oc2ccc(OCC3CC3)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C22H19FN2O4/c23-15-3-8-20(19(11-15)22(27)25-16-9-10-24-21(26)12-16)29-18-6-4-17(5-7-18)28-13-14-1-2-14/h3-12,14H,1-2,13H2,(H2,24,25,26,27)
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n/an/a 285n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161313
PNG
(US10087143, Compound 98 | US9051270, 98 | US975848...)
Show SMILES CCOc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C20H17FN2O4/c1-2-26-15-4-6-16(7-5-15)27-18-8-3-13(21)11-17(18)20(25)23-14-9-10-22-19(24)12-14/h3-12H,2H2,1H3,(H2,22,23,24,25)
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n/an/a 300n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161347
PNG
(US10087143, Compound 132 | US9051270, 132 | US9758...)
Show SMILES FC(F)(F)CCOc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C16H12F6N2O3/c17-15(18,19)4-6-27-12-2-1-9(16(20,21)22)7-11(12)14(26)24-10-3-5-23-13(25)8-10/h1-3,5,7-8H,4,6H2,(H2,23,24,25,26)
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n/an/a 330n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM339935
PNG
(US9758483, Compound 8)
Show SMILES COCCOc1ccc(Oc2cc(CF)ccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
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n/an/a 330n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161318
PNG
(US10087143, Compound 103 | US9051270, 103 | US9758...)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-13-3-5-17(15(20)10-13)27-16-4-2-11(21)8-14(16)19(25)23-12-6-7-22-18(24)9-12/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 330n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161242
PNG
(US10087143, Compound 27 | US9051270, 27 | US975848...)
Show SMILES Cc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N2O3/c1-12-2-5-15(6-3-12)28-17-7-4-13(20(21,22)23)10-16(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 340n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161219
PNG
(US10087143, Compound 4 | US9051270, 4 | US9758483,...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2ccc(=O)[nH]c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-5-14(6-3-12)28-16-7-1-11(19(21,22)23)9-15(16)18(27)25-13-4-8-17(26)24-10-13/h1-10H,(H,24,26)(H,25,27)
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n/an/a 350n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161338
PNG
(US10087143, Compound 123 | US9051270, 123 | US9758...)
Show SMILES FC(F)(F)CCCOc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)5-1-7-28-13-8-10(17(21,22)23)2-3-12(13)15(27)25-11-4-6-24-14(26)9-11/h2-4,6,8-9H,1,5,7H2,(H2,24,25,26,27)
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n/an/a 355n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161258
PNG
(US10087143, Compound 43 | US9051270, 43 | US975848...)
Show SMILES Fc1ccc(Oc2cccc(c2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-11-4-6-13(7-5-11)28-15-3-1-2-14(19(21,22)23)17(15)18(27)25-12-8-9-24-16(26)10-12/h1-10H,(H2,24,25,26,27)
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n/an/a 380n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161322
PNG
(US10087143, Compound 107 | US9051270, 107 | US9758...)
Show SMILES Fc1ccc(Oc2ccc(OCC(F)(F)F)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O4/c21-12-1-6-17(16(9-12)19(28)26-13-7-8-25-18(27)10-13)30-15-4-2-14(3-5-15)29-11-20(22,23)24/h1-10H,11H2,(H2,25,26,27,28)
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n/an/a 390n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161311
PNG
(US10087143, Compound 96 | US9051270, 96 | US975848...)
Show SMILES Fc1ccc(Oc2ccc(cc2)C2CC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C21H17FN2O3/c22-15-5-8-19(27-17-6-3-14(4-7-17)13-1-2-13)18(11-15)21(26)24-16-9-10-23-20(25)12-16/h3-13H,1-2H2,(H2,23,24,25,26)
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n/an/a 400n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161306
PNG
(US10087143, Compound 91 | US9051270, 91 | US975848...)
Show SMILES Cc1cc(C)c(C)c(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H19F3N2O3/c1-12-8-13(2)14(3)19(9-12)30-18-5-4-15(22(23,24)25)10-17(18)21(29)27-16-6-7-26-20(28)11-16/h4-11H,1-3H3,(H2,26,27,28,29)
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n/an/a 420n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161363
PNG
(US10087143, Compound 148 | US9051270, 148 | US9758...)
Show SMILES Cn1ccc(NC(=O)c2ccc(cc2Oc2ccc(nc2)C(F)(F)F)C(C)(C)C)cc1=O
Show InChI InChI=1S/C23H22F3N3O3/c1-22(2,3)14-5-7-17(21(31)28-15-9-10-29(4)20(30)12-15)18(11-14)32-16-6-8-19(27-13-16)23(24,25)26/h5-13H,1-4H3,(H,28,31)
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n/an/a 450n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161250
PNG
(US10087143, Compound 35 | US9051270, 35 | US975848...)
Show SMILES Cc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C20H15F3N2O4/c1-12-2-4-14(5-3-12)28-17-7-6-15(29-20(21,22)23)11-16(17)19(27)25-13-8-9-24-18(26)10-13/h2-11H,1H3,(H2,24,25,26,27)
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n/an/a 470n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161339
PNG
(US10087143, Compound 124 | US9051270, 124 | US9758...)
Show SMILES CC1(C)CC1COc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O3/c1-18(2)9-12(18)10-27-15-7-11(19(20,21)22)3-4-14(15)17(26)24-13-5-6-23-16(25)8-13/h3-8,12H,9-10H2,1-2H3,(H2,23,24,25,26)
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n/an/a 485n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161331
PNG
(US10087143, Compound 116 | US9051270, 116 | US9758...)
Show SMILES CC(C)CCOc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N2O3/c1-11(2)6-8-26-15-9-12(18(19,20)21)3-4-14(15)17(25)23-13-5-7-22-16(24)10-13/h3-5,7,9-11H,6,8H2,1-2H3,(H2,22,23,24,25)
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n/an/a 488n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161343
PNG
(US10087143, Compound 128 | US9051270, 128 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2CCCCC2)c1
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)12-6-7-15(16(10-12)27-14-4-2-1-3-5-14)18(26)24-13-8-9-23-17(25)11-13/h6-11,14H,1-5H2,(H2,23,24,25,26)
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n/an/a 560n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161359
PNG
(US10087143, Compound 144 | US9051270, 144 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C19H11F6N3O3/c20-18(21,22)10-1-3-13(17(30)28-11-5-6-26-16(29)8-11)14(7-10)31-12-2-4-15(27-9-12)19(23,24)25/h1-9H,(H2,26,28,29,30)
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n/an/a 615n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161357
PNG
(US10087143, Compound 142 | US9051270, 142 | US9758...)
Show SMILES CC(C)(C)c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-21(2,3)13-4-7-16(20(30)28-14-5-9-19(29)27-11-14)17(10-13)31-15-6-8-18(26-12-15)22(23,24)25/h4-12H,1-3H3,(H,27,29)(H,28,30)
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n/an/a 653n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161254
PNG
(US10087143, Compound 39 | US9051270, 39 | US975848...)
Show SMILES Cc1cccc(F)c1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-11-3-2-4-15(21)18(11)29-16-6-5-13(30-20(22,23)24)10-14(16)19(28)26-12-7-8-25-17(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 690n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161312
PNG
(US10087143, Compound 97 | US9051270, 97 | US975848...)
Show SMILES CC(C)(C)Oc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C22H21FN2O4/c1-22(2,3)29-17-7-5-16(6-8-17)28-19-9-4-14(23)12-18(19)21(27)25-15-10-11-24-20(26)13-15/h4-13H,1-3H3,(H2,24,25,26,27)
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n/an/a 745n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161333
PNG
(US10087143, Compound 118 | US9051270, 118 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2C[C@H]3CCC2C3)c1
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)13-3-4-15(19(27)25-14-5-6-24-18(26)10-14)17(9-13)28-16-8-11-1-2-12(16)7-11/h3-6,9-12,16H,1-2,7-8H2,(H2,24,25,26,27)/t11-,12?,16?/m0/s1
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n/an/a 765n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161236
PNG
(US10087143, Compound 21 | US9051270, 21 | US975848...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C#N)cc1
Show InChI InChI=1S/C19H12FN3O3/c20-13-2-4-15(5-3-13)26-17-9-12(11-21)1-6-16(17)19(25)23-14-7-8-22-18(24)10-14/h1-10H,(H2,22,23,24,25)
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n/an/a 843n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161325
PNG
(US10087143, Compound 110 | US9051270, 110 | US9758...)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1F
Show InChI InChI=1S/C20H13ClF4N2O4/c1-30-14-5-4-13(17(21)18(14)22)31-15-8-10(20(23,24)25)2-3-12(15)19(29)27-11-6-7-26-16(28)9-11/h2-9H,1H3,(H2,26,27,28,29)
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n/an/a 890n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161344
PNG
(US10087143, Compound 129 | US9051270, 129 | US9758...)
Show SMILES FC(F)(F)CCCOc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C16H14ClF3N2O3/c17-10-2-3-12(13(8-10)25-7-1-5-16(18,19)20)15(24)22-11-4-6-21-14(23)9-11/h2-4,6,8-9H,1,5,7H2,(H2,21,22,23,24)
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n/an/a 940n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161216
PNG
(US10087143, Compound 1 | US9051270, 1 | US9758483,...)
Show SMILES Fc1ccc(Oc2ccccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H13FN2O3/c19-12-5-7-14(8-6-12)24-16-4-2-1-3-15(16)18(23)21-13-9-10-20-17(22)11-13/h1-11H,(H2,20,21,22,23)
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n/an/a 1.09E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM339952
PNG
(US9758483, Compound 25)
Show SMILES FC(F)(F)c1ccc(Oc2ccc(cc2)C#N)c(c1)C(=O)Nc1cc[nH]c(=O)c1
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n/an/a 1.10E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161332
PNG
(US10087143, Compound 117 | US9051270, 117 | US9758...)
Show SMILES CC(C)COc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N2O3/c1-10(2)9-25-14-7-11(17(18,19)20)3-4-13(14)16(24)22-12-5-6-21-15(23)8-12/h3-8,10H,9H2,1-2H3,(H2,21,22,23,24)
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n/an/a 1.15E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161319
PNG
(US10087143, Compound 104 | US9051270, 104 | US9758...)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C19H15FN2O4/c1-25-14-3-5-15(6-4-14)26-17-7-2-12(20)10-16(17)19(24)22-13-8-9-21-18(23)11-13/h2-11H,1H3,(H2,21,22,23,24)
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n/an/a 1.15E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161342
PNG
(US10087143, Compound 127 | US9051270, 127 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2CC3CCC2C3)c1
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)13-3-4-15(19(27)25-14-5-6-24-18(26)10-14)17(9-13)28-16-8-11-1-2-12(16)7-11/h3-6,9-12,16H,1-2,7-8H2,(H2,24,25,26,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161375
PNG
(US10087143, Compound 160 | US9051270, 160 | US9758...)
Show SMILES Fc1ccc(Oc2ccc(OCCCC(F)(F)F)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C22H18F4N2O4/c23-14-2-7-19(18(12-14)21(30)28-15-8-10-27-20(29)13-15)32-17-5-3-16(4-6-17)31-11-1-9-22(24,25)26/h2-8,10,12-13H,1,9,11H2,(H2,27,28,29,30)
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n/an/a 1.39E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161309
PNG
(US10087143, Compound 94 | US9051270, 94 | US975848...)
Show SMILES Cc1cc(C)c(C)c(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c1
Show InChI InChI=1S/C21H19FN2O3/c1-12-8-13(2)14(3)19(9-12)27-18-5-4-15(22)10-17(18)21(26)24-16-6-7-23-20(25)11-16/h4-11H,1-3H3,(H2,23,24,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161341
PNG
(US10087143, Compound 126 | US9051270, 126 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OCC2CC2(F)F)c1
Show InChI InChI=1S/C17H13F5N2O3/c18-16(19)7-10(16)8-27-13-5-9(17(20,21)22)1-2-12(13)15(26)24-11-3-4-23-14(25)6-11/h1-6,10H,7-8H2,(H2,23,24,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161353
PNG
(US10087143, Compound 138 | US9051270, 138 | US9758...)
Show SMILES FC(F)(F)CCOc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C16H12F6N2O4/c17-15(18,19)4-6-27-12-2-1-10(28-16(20,21)22)8-11(12)14(26)24-9-3-5-23-13(25)7-9/h1-3,5,7-8H,4,6H2,(H2,23,24,25,26)
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n/an/a 1.45E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161308
PNG
(US10087143, Compound 93 | US9051270, 93 | US975848...)
Show SMILES Cc1cc(C)c(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1C
Show InChI InChI=1S/C22H19F3N2O3/c1-12-8-14(3)19(9-13(12)2)30-18-5-4-15(22(23,24)25)10-17(18)21(29)27-16-6-7-26-20(28)11-16/h4-11H,1-3H3,(H2,26,27,28,29)
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n/an/a 1.45E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161238
PNG
(US10087143, Compound 23 | US9051270, 23 | US975848...)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C#N
Show InChI InChI=1S/C20H14FN3O3/c1-12-8-14(21)3-5-17(12)27-18-9-13(11-22)2-4-16(18)20(26)24-15-6-7-23-19(25)10-15/h2-10H,1H3,(H2,23,24,25,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161346
PNG
(US10087143, Compound 131 | US9051270, 131 | US9758...)
Show SMILES CC(C)COc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N2O3/c1-10(2)9-25-14-4-3-11(17(18,19)20)7-13(14)16(24)22-12-5-6-21-15(23)8-12/h3-8,10H,9H2,1-2H3,(H2,21,22,23,24)
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161350
PNG
(US10087143, Compound 135 | US9051270, 135 | US9758...)
Show SMILES FC(F)(F)c1ccc(OC2C[C@@H]3C[C@@H]3C2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)12-1-2-16(27-14-6-10-5-11(10)7-14)15(8-12)18(26)24-13-3-4-23-17(25)9-13/h1-4,8-11,14H,5-7H2,(H2,23,24,25,26)/t10-,11+,14?
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n/an/a 1.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161364
PNG
(US10087143, Compound 149 | US9051270, 149 | US9758...)
Show SMILES Cn1cc(NC(=O)c2ccc(cc2Oc2ccc(nc2)C(F)(F)F)C(C)(C)C)ccc1=O
Show InChI InChI=1S/C23H22F3N3O3/c1-22(2,3)14-5-8-17(21(31)28-15-6-10-20(30)29(4)13-15)18(11-14)32-16-7-9-19(27-12-16)23(24,25)26/h5-13H,1-4H3,(H,28,31)
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n/an/a 1.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161232
PNG
(US10087143, Compound 17 | US9051270, 17 | US975848...)
Show SMILES Cc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-3-2-4-15(21)18(11)26-16-9-12(20)5-6-14(16)19(25)23-13-7-8-22-17(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM340086
PNG
(US9758483, Compound 159)
Show SMILES Oc1ccc(F)c(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c1
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n/an/a 2.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161351
PNG
(US10087143, Compound 136 | US9051270, 136 | US9758...)
Show SMILES FC(F)(F)Oc1ccc(OCC2CCCC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O4/c20-19(21,22)28-14-5-6-16(27-11-12-3-1-2-4-12)15(10-14)18(26)24-13-7-8-23-17(25)9-13/h5-10,12H,1-4,11H2,(H2,23,24,25,26)
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n/an/a 2.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161263
PNG
(US10087143, Compound 48 | US9051270, 48 | US975848...)
Show SMILES COc1cccc(F)c1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-16-4-2-3-14(21)18(16)30-15-6-5-11(20(22,23)24)9-13(15)19(28)26-12-7-8-25-17(27)10-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 2.70E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161300
PNG
(US10087143, Compound 85 | US9051270, 85 | US975848...)
Show SMILES OCCn1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C21H16F4N2O4/c22-14-2-4-16(5-3-14)31-18-11-13(21(23,24)25)1-6-17(18)20(30)26-15-7-8-27(9-10-28)19(29)12-15/h1-8,11-12,28H,9-10H2,(H,26,30)
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n/an/a 2.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161354
PNG
(US10087143, Compound 139 | US9051270, 139 | US9758...)
Show SMILES FC(F)(F)CCCOc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C17H14F6N2O4/c18-16(19,20)5-1-7-28-13-3-2-11(29-17(21,22)23)9-12(13)15(27)25-10-4-6-24-14(26)8-10/h2-4,6,8-9H,1,5,7H2,(H2,24,25,26,27)
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n/an/a 3.05E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161358
PNG
(US10087143, Compound 143 | US9051270, 143 | US9758...)
Show SMILES FC(F)(F)c1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)cn1
Show InChI InChI=1S/C18H11ClF3N3O3/c19-10-1-3-13(17(27)25-11-5-6-23-16(26)8-11)14(7-10)28-12-2-4-15(24-9-12)18(20,21)22/h1-9H,(H2,23,25,26,27)
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n/an/a 3.35E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161310
PNG
(US10087143, Compound 95 | US9051270, 95 | US975848...)
Show SMILES Fc1ccc(Oc2ccccc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H13FN2O3/c19-12-6-7-16(24-14-4-2-1-3-5-14)15(10-12)18(23)21-13-8-9-20-17(22)11-13/h1-11H,(H2,20,21,22,23)
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n/an/a 3.45E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161301
PNG
(US10087143, Compound 86 | US9051270, 86 | US975848...)
Show SMILES Cc1c[nH]c(=O)cc1NC(=O)c1ccc(cc1Oc1ccc(F)cc1C)C(F)(F)F
Show InChI InChI=1S/C21H16F4N2O3/c1-11-7-14(22)4-6-17(11)30-18-8-13(21(23,24)25)3-5-15(18)20(29)27-16-9-19(28)26-10-12(16)2/h3-10H,1-2H3,(H2,26,27,28,29)
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n/an/a 3.55E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161320
PNG
(US10087143, Compound 105 | US9051270, 105 | US9758...)
Show SMILES Cc1cc(C)c(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1C
Show InChI InChI=1S/C21H19FN2O3/c1-12-8-14(3)19(9-13(12)2)27-18-5-4-15(22)10-17(18)21(26)24-16-6-7-23-20(25)11-16/h4-11H,1-3H3,(H2,23,24,25,26)
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n/an/a 3.55E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161362
PNG
(US10087143, Compound 147 | US9051270, 147 | US9758...)
Show SMILES Cc1ncccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H14F3N3O3/c1-11-15(3-2-7-23-11)28-16-9-12(19(20,21)22)4-5-14(16)18(27)25-13-6-8-24-17(26)10-13/h2-10H,1H3,(H2,24,25,26,27)
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n/an/a 3.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161337
PNG
(US10087143, Compound 122 | US9051270, 122 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2CCC2)c1
Show InChI InChI=1S/C17H15F3N2O3/c18-17(19,20)10-4-5-13(14(8-10)25-12-2-1-3-12)16(24)22-11-6-7-21-15(23)9-11/h4-9,12H,1-3H2,(H2,21,22,23,24)
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n/an/a 4.20E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161361
PNG
(US10087143, Compound 146 | US9051270, 146 | US9758...)
Show SMILES Cc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cn1
Show InChI InChI=1S/C19H14F3N3O3/c1-11-2-4-14(10-24-11)28-16-8-12(19(20,21)22)3-5-15(16)18(27)25-13-6-7-23-17(26)9-13/h2-10H,1H3,(H2,23,25,26,27)
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n/an/a 4.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161360
PNG
(US10087143, Compound 145 | US9051270, 145 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C19H11F6N3O3/c20-18(21,22)10-1-4-13(17(30)28-11-2-6-16(29)27-8-11)14(7-10)31-12-3-5-15(26-9-12)19(23,24)25/h1-9H,(H,27,29)(H,28,30)
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n/an/a 5.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161345
PNG
(US10087143, Compound 130 | US9051270, 130 | US9758...)
Show SMILES FC(F)(F)c1ccc(OCC2CCCC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)13-5-6-16(27-11-12-3-1-2-4-12)15(9-13)18(26)24-14-7-8-23-17(25)10-14/h5-10,12H,1-4,11H2,(H2,23,24,25,26)
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n/an/a 5.10E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161314
PNG
(US10087143, Compound 99 | US9051270, 99 | US975848...)
Show SMILES CC(C)c1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C21H19FN2O3/c1-13(2)14-3-6-17(7-4-14)27-19-8-5-15(22)11-18(19)21(26)24-16-9-10-23-20(25)12-16/h3-13H,1-2H3,(H2,23,24,25,26)
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n/an/a 5.15E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161289
PNG
(US10087143, Compound 74 | US9051270, 74 | US975848...)
Show SMILES FC(F)(F)c1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O3/c21-19(22,23)11-1-4-14(5-2-11)31-16-6-3-12(20(24,25)26)9-15(16)18(30)28-13-7-8-27-17(29)10-13/h1-10H,(H2,27,28,29,30)
PDB

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n/an/a 5.18E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161348
PNG
(US10087143, Compound 133 | US9051270, 133 | US9758...)
Show SMILES FC(F)(F)CCCOc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)5-1-7-28-13-3-2-10(17(21,22)23)8-12(13)15(27)25-11-4-6-24-14(26)9-11/h2-4,6,8-9H,1,5,7H2,(H2,24,25,26,27)
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n/an/a 5.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161234
PNG
(US10087143, Compound 19 | US9051270, 19 | US975848...)
Show SMILES Fc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 6.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161365
PNG
(US10087143, Compound 150 | US9051270, 150 | US9758...)
Show SMILES Cc1ncccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H14F3N3O3/c1-11-15(3-2-7-23-11)28-16-5-4-12(19(20,21)22)9-14(16)18(27)25-13-6-8-24-17(26)10-13/h2-10H,1H3,(H2,24,25,26,27)
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n/an/a 6.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161272
PNG
(US10087143, Compound 57 | US9051270, 57 | US975848...)
Show SMILES COc1cc(F)cc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-29-14-7-12(21)8-15(10-14)30-17-3-2-11(20(22,23)24)6-16(17)19(28)26-13-4-5-25-18(27)9-13/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 6.90E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161366
PNG
(US10087143, Compound 151 | US9051270, 151 | US9758...)
Show SMILES Cc1ncccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14F3N3O4/c1-11-15(3-2-7-23-11)28-16-5-4-13(29-19(20,21)22)10-14(16)18(27)25-12-6-8-24-17(26)9-12/h2-10H,1H3,(H2,24,25,26,27)
PDB

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n/an/a 8.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161241
PNG
(US10087143, Compound 26 | US9051270, 26 | US975848...)
Show SMILES Fc1cccc(F)c1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H11F5N2O3/c20-13-2-1-3-14(21)17(13)29-15-5-4-10(19(22,23)24)8-12(15)18(28)26-11-6-7-25-16(27)9-11/h1-9H,(H2,25,26,27,28)
PDB

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n/an/a 9.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161233
PNG
(US10087143, Compound 18 | US9051270, 18 | US975848...)
Show SMILES Fc1cccc(Cl)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 1.20E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161249
PNG
(US10087143, Compound 34 | US9051270, 34 | US975848...)
Show SMILES Fc1cccc(F)c1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H11F5N2O4/c20-13-2-1-3-14(21)17(13)29-15-5-4-11(30-19(22,23)24)9-12(15)18(28)26-10-6-7-25-16(27)8-10/h1-9H,(H2,25,26,27,28)
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n/an/a 1.20E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161352
PNG
(US10087143, Compound 137 | US9051270, 137 | US9758...)
Show SMILES FC(F)(F)Oc1ccc(OC2CCCCC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O4/c20-19(21,22)28-14-6-7-16(27-13-4-2-1-3-5-13)15(11-14)18(26)24-12-8-9-23-17(25)10-12/h6-11,13H,1-5H2,(H2,23,24,25,26)
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n/an/a 1.27E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161218
PNG
(US10087143, Compound 3 | US9051270, 3 | US9758483,...)
Show SMILES Fc1ccc(Oc2ccccc2C(=O)Nc2ccc(=O)[nH]c2)cc1
Show InChI InChI=1S/C18H13FN2O3/c19-12-5-8-14(9-6-12)24-16-4-2-1-3-15(16)18(23)21-13-7-10-17(22)20-11-13/h1-11H,(H,20,22)(H,21,23)
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n/an/a 1.35E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161334
PNG
(US10087143, Compound 119 | US9051270, 119 | US9758...)
Show SMILES CC1(COc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H17F3N2O3/c1-17(5-6-17)10-26-14-8-11(18(19,20)21)2-3-13(14)16(25)23-12-4-7-22-15(24)9-12/h2-4,7-9H,5-6,10H2,1H3,(H2,22,23,24,25)
PDB

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n/an/a 1.40E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161355
PNG
(US9051270, 140 | US9758483, Compound 140)
Show SMILES CC1(C)CC1COc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O4/c1-18(2)9-11(18)10-27-15-4-3-13(28-19(20,21)22)8-14(15)17(26)24-12-5-6-23-16(25)7-12/h3-8,11H,9-10H2,1-2H3,(H2,23,24,25,26)
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n/an/a 1.50E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161317
PNG
(US10087143, Compound 102 | US9051270, 102 | US9758...)
Show SMILES COCCc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C21H19FN2O4/c1-27-11-9-14-2-5-17(6-3-14)28-19-7-4-15(22)12-18(19)21(26)24-16-8-10-23-20(25)13-16/h2-8,10,12-13H,9,11H2,1H3,(H2,23,24,25,26)
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n/an/a 1.71E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161340
PNG
(US10087143, Compound 125 | US9051270, 125 | US9758...)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2C[C@@H]3C[C@@H]3C2)c1
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)12-1-2-15(18(26)24-13-3-4-23-17(25)9-13)16(8-12)27-14-6-10-5-11(10)7-14/h1-4,8-11,14H,5-7H2,(H2,23,24,25,26)/t10-,11+,14?
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n/an/a 1.75E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM340048
PNG
(US9758483, Compound 121)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OCC2CCCO2)c1
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n/an/a 1.90E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161349
PNG
(US10087143, Compound 140 | US9051270, 134 | US9758...)
Show SMILES CC1(C)CC1COc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O3/c1-18(2)9-12(18)10-27-15-4-3-11(19(20,21)22)7-14(15)17(26)24-13-5-6-23-16(25)8-13/h3-8,12H,9-10H2,1-2H3,(H2,23,24,25,26)
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n/an/a 2.10E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...


US Patent US9758483 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%