Compile Data Set for Download or QSAR
maximum 50k data
Found 35 Enz. Inhib. hit(s) with all data for entry = 1783
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339961(5-(6-fluoro-1H-indol-3-yl)-N- methylpyridin-2-amin...)
Affinity DataIC50:  290nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339928(6-fluoro-3-(6-methylpyridin-3- yl)-1H-indole | US9...)
Affinity DataIC50:  370nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339940(5-(6-fluoro-1H-indol-3-yl)- N,N-dimethylpyridin-2-...)
Affinity DataIC50:  380nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339957(2-((5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)amino)...)
Affinity DataIC50:  490nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339941(4-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)morphol...)
Affinity DataIC50:  540nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339955(N1-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)-N2,N2...)
Affinity DataIC50:  540nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339929(6-fluoro-3-(6-(piperidin-4- yloxy)pyridin-3-yl)-1H...)
Affinity DataIC50:  560nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339953(N-(3-((5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)ami...)
Affinity DataIC50:  620nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339950(5-(6-fluoro-1H-indol-3-yl)-N- (1-(methylsulfonyl)p...)
Affinity DataIC50:  650nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339943(2-amino-1-(4-(5-(6-fluoro-1H- indol-3-yl)pyridin-2...)
Affinity DataIC50:  650nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339956(N-(2-((5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)ami...)
Affinity DataIC50:  710nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339942(6-fluoro-3-(6-(4- methylpiperazin-1-yl)pyridin- 3-...)
Affinity DataIC50:  720nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339938(6-fluoro-3-(6-methoxypyridin- 3-yl)-1H-indole | US...)
Affinity DataIC50:  730nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339960(2-((5-(6-fluoro-1H-indol-3- yl)pyridin-2- yl)amino...)
Affinity DataIC50:  790nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339963(6-fluoro-3-(pyridin-3-yl)-1H- indole | US9758505, ...)
Affinity DataIC50:  850nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339964(6-fluoro-3-(2-methylpyridin-3- yl)-1H-indole | US9...)
Affinity DataIC50:  860nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339948(5-(6-fluoro-1H-indol-3-yl)-N- (piperidin-4-yl)pyri...)
Affinity DataIC50:  870nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339951(N-(3-((5-(6-fluoro-1H-indol-3- yl)pyridin-2- yl)am...)
Affinity DataIC50:  870nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339945(N-(1-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)pipe...)
Affinity DataIC50:  970nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339962(N-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)acetami...)
Affinity DataIC50:  1.00E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339946(5-(6-fluoro-1H-indol-3- yl)pyridin-2-amine | US975...)
Affinity DataIC50:  1.10E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339936(6-fluoro-3-(6-((1- methylpiperidin-4- yl)oxy)pyrid...)
Affinity DataIC50:  1.20E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339954(5-(6-fluoro-1H-indol-3-yl)-N- (3-(methylsulfonyl)p...)
Affinity DataIC50:  1.20E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339939(5-(6-fluoro-1H-indol-3-yl)-N- (1-(methylsulfonyl)p...)
Affinity DataIC50:  1.30E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339958(5-(6-fluoro-1H-indol-3-yl)-N- (2-(methylsulfonyl)e...)
Affinity DataIC50:  1.50E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339959(2-((5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)amino)...)
Affinity DataIC50:  1.60E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339947(5-(5,6-difluoro-1H-indol-3- yl)pyridin-2-amine | U...)
Affinity DataIC50:  1.60E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339944(2-amino-N-(1-(5-(6-fluoro- 1H-indol-3-yl)pyridin-2...)
Affinity DataIC50:  1.70E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339966(5,6-difluoro-3-(pyridin-3-yl)- 1H-indole | US97585...)
Affinity DataIC50:  2.80E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339967(6-fluoro-3-(5-methylpyridin-3- yl)-1H-indole | US9...)
Affinity DataIC50:  4.50E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339949(N-(1-ethylpiperidin-4-yl)-5-(6- fluoro-1H-indol-3-...)
Affinity DataIC50:  4.80E+3nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339968(3-(6-fluoro-1H-indol-3- yl)pyridine 1-oxide | US97...)
Affinity DataIC50:  1.10E+4nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339965(6-fluoro-3-(4-methylpyridin-3- yl)-1H-indole | US9...)
Affinity DataIC50:  1.30E+4nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339969(1-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)imidazo...)
Affinity DataIC50:  1.60E+4nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM339937(2-((5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)oxy)-N...)
Affinity DataIC50:  3.90E+4nMAssay Description:The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent