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Patent code US9758517

Compile Data Set for Download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340045
PNG
(2-(5-Cyclopropyl-2-methyl-2H-indazol-3-yl)-1H-pyrr...)
Show SMILES Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C1CC1
PDB

UniProtKB/SwissProt

GoogleScholar
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UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340055
PNG
(2-(6-Chloro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(Cl)cc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340053
PNG
(2-(1-Methyl-1H-indazol-3-yl)-1H-pyrrolo[3,2-b]pyri...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340056
PNG
(2-(6-Fluoro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(F)cc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340042
PNG
(2-(6-Chloro-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc2cc(Cl)ccc2c1-c1cc2nccc(C(O)=O)c2[nH]1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340050
PNG
(2-{5-Chloro-2-[2-(pyrrolidin-1-yl)ethyl]-2H-indazo...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1n(CCN2CCCC2)nc2ccc(Cl)cc12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340041
PNG
(2-(5-Methoxy-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[...)
Show SMILES COc1ccc2nn(C)c(-c3cc4nccc(C(O)=O)c4[nH]3)c2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340040
PNG
(2-(6-Methoxy-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[...)
Show SMILES COc1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340060
PNG
(2-{5-Chloro-1-[2-(pyrrolidin-1-yl)ethyl]-1H-indazo...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CCN2CCCC2)c2ccc(Cl)cc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340054
PNG
(2-(5-Fluoro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2cc(F)ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340051
PNG
(2-{2-Methyl-6-[methyl(phenyl)amino]-2H-indazol-3-y...)
Show SMILES CN(c1ccccc1)c1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340047
PNG
(2-(6-Chloro-2-ethyl-2H-indazol-3-yl)-1H-pyrrolo[3,...)
Show SMILES CCn1nc2cc(Cl)ccc2c1-c1cc2nccc(C(O)=O)c2[nH]1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340044
PNG
(2-[2-Methyl-5-(trifluoromethoxy)-2H-indazol-3-yl]-...)
Show SMILES Cn1nc2ccc(OC(F)(F)F)cc2c1-c1cc2nccc(C(O)=O)c2[nH]1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340061
PNG
(2-{5-Fluoro-1-[2-(morpholin-4-yl)ethyl]-1H-indazol...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CCN2CCOCC2)c2ccc(F)cc12
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340043
PNG
(2-[2-Methyl-5-(trifluoromethyl)-2H-indazol-3-yl]-1...)
Show SMILES Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340046
PNG
(2-(5-Chloro-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc2ccc(Cl)cc2c1-c1cc2nccc(C(O)=O)c2[nH]1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340049
PNG
(2-[6-Chloro-2-(cyclopropylmethyl)-2H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1n(CC2CC2)nc2cc(Cl)ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340052
PNG
(2-{2-Methyl-7-[methyl(phenyl)amino]-2H-indazol-3-y...)
Show SMILES CN(c1ccccc1)c1cccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340059
PNG
(2-[6-Chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC(F)(F)F)c2cc(Cl)ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340058
PNG
(2-[6-Chloro-1-(cyclopropylmethyl)-1H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC2CC2)c2cc(Cl)ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340057
PNG
(2-(6-Chloro-1-ethyl-1H-indazol-3-yl)-1H-pyrrolo[3,...)
Show SMILES CCn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(Cl)cc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%