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Patent code US9758517

Compile Data Set for Download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340040
PNG
(2-(6-Methoxy-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[...)
Show SMILES COc1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1
Show InChI InChI=1S/C17H14N4O3/c1-21-16(10-4-3-9(24-2)7-12(10)20-21)14-8-13-15(19-14)11(17(22)23)5-6-18-13/h3-8,19H,1-2H3,(H,22,23)
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US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340057
PNG
(2-(6-Chloro-1-ethyl-1H-indazol-3-yl)-1H-pyrrolo[3,...)
Show SMILES CCn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(Cl)cc12
Show InChI InChI=1S/C17H13ClN4O2/c1-2-22-14-7-9(18)3-4-10(14)16(21-22)13-8-12-15(20-13)11(17(23)24)5-6-19-12/h3-8,20H,2H2,1H3,(H,23,24)
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340045
PNG
(2-(5-Cyclopropyl-2-methyl-2H-indazol-3-yl)-1H-pyrr...)
Show SMILES Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-23-18(13-8-11(10-2-3-10)4-5-14(13)22-23)16-9-15-17(21-16)12(19(24)25)6-7-20-15/h4-10,21H,2-3H2,1H3,(H,24,25)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340051
PNG
(2-{2-Methyl-6-[methyl(phenyl)amino]-2H-indazol-3-y...)
Show SMILES CN(c1ccccc1)c1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1
Show InChI InChI=1S/C23H19N5O2/c1-27(14-6-4-3-5-7-14)15-8-9-16-18(12-15)26-28(2)22(16)20-13-19-21(25-20)17(23(29)30)10-11-24-19/h3-13,25H,1-2H3,(H,29,30)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340052
PNG
(2-{2-Methyl-7-[methyl(phenyl)amino]-2H-indazol-3-y...)
Show SMILES CN(c1ccccc1)c1cccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc12
Show InChI InChI=1S/C23H19N5O2/c1-27(14-7-4-3-5-8-14)19-10-6-9-15-21(19)26-28(2)22(15)18-13-17-20(25-18)16(23(29)30)11-12-24-17/h3-13,25H,1-2H3,(H,29,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340053
PNG
(2-(1-Methyl-1H-indazol-3-yl)-1H-pyrrolo[3,2-b]pyri...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccccc12
Show InChI InChI=1S/C16H12N4O2/c1-20-13-5-3-2-4-9(13)15(19-20)12-8-11-14(18-12)10(16(21)22)6-7-17-11/h2-8,18H,1H3,(H,21,22)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340054
PNG
(2-(5-Fluoro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2cc(F)ccc12
Show InChI InChI=1S/C16H11FN4O2/c1-21-13-3-2-8(17)6-10(13)15(20-21)12-7-11-14(19-12)9(16(22)23)4-5-18-11/h2-7,19H,1H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340059
PNG
(2-[6-Chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC(F)(F)F)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H10ClF3N4O2/c18-8-1-2-9-13(5-8)25(7-17(19,20)21)24-15(9)12-6-11-14(23-12)10(16(26)27)3-4-22-11/h1-6,23H,7H2,(H,26,27)
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n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340042
PNG
(2-(6-Chloro-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc2cc(Cl)ccc2c1-c1cc2nccc(C(O)=O)c2[nH]1
Show InChI InChI=1S/C16H11ClN4O2/c1-21-15(9-3-2-8(17)6-11(9)20-21)13-7-12-14(19-13)10(16(22)23)4-5-18-12/h2-7,19H,1H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340043
PNG
(2-[2-Methyl-5-(trifluoromethyl)-2H-indazol-3-yl]-1...)
Show SMILES Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C17H11F3N4O2/c1-24-15(10-6-8(17(18,19)20)2-3-11(10)23-24)13-7-12-14(22-13)9(16(25)26)4-5-21-12/h2-7,22H,1H3,(H,25,26)
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340046
PNG
(2-(5-Chloro-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc2ccc(Cl)cc2c1-c1cc2nccc(C(O)=O)c2[nH]1
Show InChI InChI=1S/C16H11ClN4O2/c1-21-15(10-6-8(17)2-3-11(10)20-21)13-7-12-14(19-13)9(16(22)23)4-5-18-12/h2-7,19H,1H3,(H,22,23)
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340056
PNG
(2-(6-Fluoro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(F)cc12
Show InChI InChI=1S/C16H11FN4O2/c1-21-13-6-8(17)2-3-9(13)15(20-21)12-7-11-14(19-12)10(16(22)23)4-5-18-11/h2-7,19H,1H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340058
PNG
(2-[6-Chloro-1-(cyclopropylmethyl)-1H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC2CC2)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN4O2/c20-11-3-4-12-16(7-11)24(9-10-1-2-10)23-18(12)15-8-14-17(22-15)13(19(25)26)5-6-21-14/h3-8,10,22H,1-2,9H2,(H,25,26)
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n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340041
PNG
(2-(5-Methoxy-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[...)
Show SMILES COc1ccc2nn(C)c(-c3cc4nccc(C(O)=O)c4[nH]3)c2c1
Show InChI InChI=1S/C17H14N4O3/c1-21-16(11-7-9(24-2)3-4-12(11)20-21)14-8-13-15(19-14)10(17(22)23)5-6-18-13/h3-8,19H,1-2H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340060
PNG
(2-{5-Chloro-1-[2-(pyrrolidin-1-yl)ethyl]-1H-indazo...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CCN2CCCC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C21H20ClN5O2/c22-13-3-4-18-15(11-13)20(25-27(18)10-9-26-7-1-2-8-26)17-12-16-19(24-17)14(21(28)29)5-6-23-16/h3-6,11-12,24H,1-2,7-10H2,(H,28,29)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340047
PNG
(2-(6-Chloro-2-ethyl-2H-indazol-3-yl)-1H-pyrrolo[3,...)
Show SMILES CCn1nc2cc(Cl)ccc2c1-c1cc2nccc(C(O)=O)c2[nH]1
Show InChI InChI=1S/C17H13ClN4O2/c1-2-22-16(10-4-3-9(18)7-12(10)21-22)14-8-13-15(20-14)11(17(23)24)5-6-19-13/h3-8,20H,2H2,1H3,(H,23,24)
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340049
PNG
(2-[6-Chloro-2-(cyclopropylmethyl)-2H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1n(CC2CC2)nc2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN4O2/c20-11-3-4-12-14(7-11)23-24(9-10-1-2-10)18(12)16-8-15-17(22-16)13(19(25)26)5-6-21-15/h3-8,10,22H,1-2,9H2,(H,25,26)
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340061
PNG
(2-{5-Fluoro-1-[2-(morpholin-4-yl)ethyl]-1H-indazol...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CCN2CCOCC2)c2ccc(F)cc12
Show InChI InChI=1S/C21H20FN5O3/c22-13-1-2-18-15(11-13)20(25-27(18)6-5-26-7-9-30-10-8-26)17-12-16-19(24-17)14(21(28)29)3-4-23-16/h1-4,11-12,24H,5-10H2,(H,28,29)
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n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340050
PNG
(2-{5-Chloro-2-[2-(pyrrolidin-1-yl)ethyl]-2H-indazo...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1n(CCN2CCCC2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H20ClN5O2/c22-13-3-4-16-15(11-13)20(27(25-16)10-9-26-7-1-2-8-26)18-12-17-19(24-18)14(21(28)29)5-6-23-17/h3-6,11-12,24H,1-2,7-10H2,(H,28,29)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340055
PNG
(2-(6-Chloro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(Cl)cc12
Show InChI InChI=1S/C16H11ClN4O2/c1-21-13-6-8(17)2-3-9(13)15(20-21)12-7-11-14(19-12)10(16(22)23)4-5-18-11/h2-7,19H,1H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340044
PNG
(2-[2-Methyl-5-(trifluoromethoxy)-2H-indazol-3-yl]-...)
Show SMILES Cn1nc2ccc(OC(F)(F)F)cc2c1-c1cc2nccc(C(O)=O)c2[nH]1
Show InChI InChI=1S/C17H11F3N4O3/c1-24-15(10-6-8(27-17(18,19)20)2-3-11(10)23-24)13-7-12-14(22-13)9(16(25)26)4-5-21-12/h2-7,22H,1H3,(H,25,26)
PDB

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UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%