BindingDB logo
myBDB logout

Patent code US9758523

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304046
PNG
(4-{5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-y...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2n[nH]c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5O2/c1-16-2-6-20(7-3-16)23-21(19-8-4-17(13-26)5-9-19)12-22(24-28-29-25(31)30(23)24)32-15-18-10-11-27-14-18/h2-9,12,18,27H,10-11,14-15H2,1H3,(H,29,31)/t18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304056
PNG
(4-{5-(4-methylphenyl)-3-oxo-2-(piperidin-4-ylmethy...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC3CCNCC3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C31H34N6O2/c1-21-2-6-26(7-3-21)29-27(25-8-4-22(17-32)5-9-25)16-28(39-20-24-12-15-34-18-24)30-35-36(31(38)37(29)30)19-23-10-13-33-14-11-23/h2-9,16,23-24,33-34H,10-15,18-20H2,1H3/t24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304050
PNG
(4-{2-(cyclopentylmethyl)-5-(4-methylphenyl)-3-oxo-...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC3CCCC3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C31H33N5O2/c1-21-6-10-26(11-7-21)29-27(25-12-8-22(17-32)9-13-25)16-28(38-20-24-14-15-33-18-24)30-34-35(31(37)36(29)30)19-23-4-2-3-5-23/h6-13,16,23-24,33H,2-5,14-15,18-20H2,1H3/t24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304059
PNG
(4-{2-benzyl-5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrro...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(Cc3ccccc3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C32H29N5O2/c1-22-7-11-27(12-8-22)30-28(26-13-9-23(18-33)10-14-26)17-29(39-21-25-15-16-34-19-25)31-35-36(32(38)37(30)31)20-24-5-3-2-4-6-24/h2-14,17,25,34H,15-16,19-21H2,1H3/t25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304058
PNG
(4-{2-[2-(dimethylamino)ethyl]-5-(4-methylphenyl)-3...)
Show SMILES CN(C)CCn1nc2c(OC[C@@H]3CCNC3)cc(-c3ccc(cc3)C#N)c(-c3ccc(C)cc3)n2c1=O
Show InChI InChI=1S/C29H32N6O2/c1-20-4-8-24(9-5-20)27-25(23-10-6-21(17-30)7-11-23)16-26(37-19-22-12-13-31-18-22)28-32-34(15-14-33(2)3)29(36)35(27)28/h4-11,16,22,31H,12-15,18-19H2,1-3H3/t22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304048
PNG
((R)-4-(2-(cyanomethyl)-3-oxo-8-(pyrrolidin-3-ylmet...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC#N)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H24N6O2/c1-18-2-6-22(7-3-18)25-23(21-8-4-19(15-29)5-9-21)14-24(35-17-20-10-12-30-16-20)26-31-32(13-11-28)27(34)33(25)26/h2-9,14,20,30H,10,12-13,16-17H2,1H3/t20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304057
PNG
(4-{5-(4-methylphenyl)-3-oxo-2-(2-phenoxyethyl)-8-[...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CCOc3ccccc3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C33H31N5O3/c1-23-7-11-27(12-8-23)31-29(26-13-9-24(20-34)10-14-26)19-30(41-22-25-15-16-35-21-25)32-36-37(33(39)38(31)32)17-18-40-28-5-3-2-4-6-28/h2-14,19,25,35H,15-18,21-22H2,1H3/t25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304049
PNG
(4-{2-(2-cyanoethyl)-5-(4-methylphenyl)-3-oxo-8-[(3...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CCC#N)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H26N6O2/c1-19-3-7-23(8-4-19)26-24(22-9-5-20(16-30)6-10-22)15-25(36-18-21-11-13-31-17-21)27-32-33(14-2-12-29)28(35)34(26)27/h3-10,15,21,31H,2,11,13-14,17-18H2,1H3/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM340063
PNG
(2-fluoro-4-{5-(4-methylphenyl)-8-[(3R)-pyrrolidin-...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCN(C2)C(=O)OC(C)(C)C)c2nncn12)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C30H30FN5O3/c1-19-5-7-21(8-6-19)27-24(22-9-10-23(15-32)25(31)13-22)14-26(28-34-33-18-36(27)28)38-17-20-11-12-35(16-20)29(37)39-30(2,3)4/h5-10,13-14,18,20H,11-12,16-17H2,1-4H3/t20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304044
PNG
(4-{5-(4-methylphenyl)-8-[(3R)-pyrrolidin-3-ylmetho...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nncn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5O/c1-17-2-6-21(7-3-17)24-22(20-8-4-18(13-26)5-9-20)12-23(25-29-28-16-30(24)25)31-15-19-10-11-27-14-19/h2-9,12,16,19,27H,10-11,14-15H2,1H3/t19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304060
PNG
(4-{2-(4-cyanobenzyl)-5-(4-methylphenyl)-3-oxo-8-[(...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(Cc3ccc(cc3)C#N)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C33H28N6O2/c1-22-2-10-28(11-3-22)31-29(27-12-8-24(18-35)9-13-27)16-30(41-21-26-14-15-36-19-26)32-37-38(33(40)39(31)32)20-25-6-4-23(17-34)5-7-25/h2-13,16,26,36H,14-15,19-21H2,1H3/t26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304055
PNG
(4-[5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-y...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC(O)C(F)(F)F)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H26F3N5O3/c1-17-2-6-21(7-3-17)25-22(20-8-4-18(13-32)5-9-20)12-23(39-16-19-10-11-33-14-19)26-34-35(27(38)36(25)26)15-24(37)28(29,30)31/h2-9,12,19,24,33,37H,10-11,14-16H2,1H3/t19-,24?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304061
PNG
(4-{2-(2-hydroxyethyl)-5-(4-methylphenyl)-3-oxo-8-[...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CCO)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H27N5O3/c1-18-2-6-22(7-3-18)25-23(21-8-4-19(15-28)5-9-21)14-24(35-17-20-10-11-29-16-20)26-30-31(12-13-33)27(34)32(25)26/h2-9,14,20,29,33H,10-13,16-17H2,1H3/t20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304053
PNG
(4-{5-(4-methylphenyl)-2-(2-morpholin-4-ylethyl)-3-...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CCN3CCOCC3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C31H34N6O3/c1-22-2-6-26(7-3-22)29-27(25-8-4-23(19-32)5-9-25)18-28(40-21-24-10-11-33-20-24)30-34-36(31(38)37(29)30)13-12-35-14-16-39-17-15-35/h2-9,18,24,33H,10-17,20-21H2,1H3/t24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304063
PNG
(4-{5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-y...)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2n[nH]c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H22N6O2/c1-15-2-6-19(7-3-15)21-20(18-8-4-16(12-25)5-9-18)27-23(22-28-29-24(31)30(21)22)32-14-17-10-11-26-13-17/h2-9,17,26H,10-11,13-14H2,1H3,(H,29,31)/t17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304052
PNG
(4-{5-(4-methylphenyl)-2-[(1-methyl-1H-pyrazol-3-yl...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(Cc3ccn(C)n3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H29N7O2/c1-20-3-7-24(8-4-20)28-26(23-9-5-21(16-31)6-10-23)15-27(39-19-22-11-13-32-17-22)29-34-36(30(38)37(28)29)18-25-12-14-35(2)33-25/h3-10,12,14-15,22,32H,11,13,17-19H2,1-2H3/t22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304054
PNG
(2-[6-(4-cyanophenyl)-5-(4-methylphenyl)-3-oxo-8-[(...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC(N)=O)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H26N6O3/c1-17-2-6-21(7-3-17)25-22(20-8-4-18(13-28)5-9-20)12-23(36-16-19-10-11-30-14-19)26-31-32(15-24(29)34)27(35)33(25)26/h2-9,12,19,30H,10-11,14-16H2,1H3,(H2,29,34)/t19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304062
PNG
(4-{5-(4-methylphenyl)-8-[(3R)-pyrrolidin-3-ylmetho...)
Show SMILES Cc1ccc(cc1)-c1c(nc(OC[C@@H]2CCNC2)c2nncn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H22N6O/c1-16-2-6-20(7-3-16)22-21(19-8-4-17(12-25)5-9-19)28-24(23-29-27-15-30(22)23)31-14-18-10-11-26-13-18/h2-9,15,18,26H,10-11,13-14H2,1H3/t18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304051
PNG
(4-[5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-y...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC3CCCO3)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C30H31N5O3/c1-20-4-8-24(9-5-20)28-26(23-10-6-21(16-31)7-11-23)15-27(38-19-22-12-13-32-17-22)29-33-34(30(36)35(28)29)18-25-3-2-14-37-25/h4-11,15,22,25,32H,2-3,12-14,17-19H2,1H3/t22-,25?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM304047
PNG
(4-{2-methyl-5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrro...)
Show SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(C)c(=O)n12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5O2/c1-17-3-7-21(8-4-17)24-22(20-9-5-18(14-27)6-10-20)13-23(33-16-19-11-12-28-15-19)25-29-30(2)26(32)31(24)25/h3-10,13,19,28H,11-12,15-16H2,1-2H3/t19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9758523 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%