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Patent code US9763922

Compile Data Set for Download or QSAR

Found 595 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM340472
PNG
(US9763922, Example 3)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(-c3cnn(C)c3)c1F)nn2C
Show InChI InChI=1S/C19H21FN6O/c1-12(27)26-8-7-17-15(11-26)19(23-25(17)3)22-16-6-4-5-14(18(16)20)13-9-21-24(2)10-13/h4-6,9-10H,7-8,11H2,1-3H3,(H,22,23)
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n/an/a 120n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340476
PNG
(US9763922, Example 7)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(F)c1)nn2C
Show InChI InChI=1S/C19H21FN6O/c1-12(27)26-7-6-18-16(11-26)19(23-25(18)3)22-14-4-5-15(17(20)8-14)13-9-21-24(2)10-13/h4-5,8-10H,6-7,11H2,1-3H3,(H,22,23)
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340476
PNG
(US9763922, Example 7)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(F)c1)nn2C
Show InChI InChI=1S/C19H21FN6O/c1-12(27)26-7-6-18-16(11-26)19(23-25(18)3)22-14-4-5-15(17(20)8-14)13-9-21-24(2)10-13/h4-5,8-10H,6-7,11H2,1-3H3,(H,22,23)
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n/an/a 6.22E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340477
PNG
(1-(1-methyl-3-((1-methyl-1H-pyrazol-4-yl)amino)-6,...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cnn(C)c1)nn2C
Show InChI InChI=1S/C13H18N6O/c1-9(20)19-5-4-12-11(8-19)13(16-18(12)3)15-10-6-14-17(2)7-10/h6-7H,4-5,8H2,1-3H3,(H,15,16)
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n/an/a 1.43E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340485
PNG
(US9763922, Example 16)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc3n(C)ncc3c1)nn2C
Show InChI InChI=1S/C17H20N6O/c1-11(24)23-7-6-16-14(10-23)17(20-22(16)3)19-13-4-5-15-12(8-13)9-18-21(15)2/h4-5,8-9H,6-7,10H2,1-3H3,(H,19,20)
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n/an/a 190n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340485
PNG
(US9763922, Example 16)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc3n(C)ncc3c1)nn2C
Show InChI InChI=1S/C17H20N6O/c1-11(24)23-7-6-16-14(10-23)17(20-22(16)3)19-13-4-5-15-12(8-13)9-18-21(15)2/h4-5,8-9H,6-7,10H2,1-3H3,(H,19,20)
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n/an/a 1.81E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340489
PNG
(3-[(5-acetyl-1-methyl-6,7-dihydro-4H-pyrazolo[4,3-...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(cc(c1)-c1cnn(C)c1)C#N)nn2C
Show InChI InChI=1S/C20H21N7O/c1-13(28)27-5-4-19-18(12-27)20(24-26(19)3)23-17-7-14(9-21)6-15(8-17)16-10-22-25(2)11-16/h6-8,10-11H,4-5,12H2,1-3H3,(H,23,24)
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n/an/a 3.82E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340491
PNG
(US9763922, Example 22)
Show SMILES CNC1=C(CN(CC1)C(C)=O)C(=N)Nc1cc(-c2cnn(C)c2)c(F)cc1F
Show InChI InChI=1S/C19H22F2N6O/c1-11(28)27-5-4-17(23-2)14(10-27)19(22)25-18-6-13(15(20)7-16(18)21)12-8-24-26(3)9-12/h6-9,23H,4-5,10H2,1-3H3,(H2,22,25)
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n/an/a 7.80E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340499
PNG
(US9763922, Example 30)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(ccn1)-c1cnn(C)c1)nn2C
Show InChI InChI=1S/C18H21N7O/c1-12(26)25-7-5-16-15(11-25)18(22-24(16)3)21-17-8-13(4-6-19-17)14-9-20-23(2)10-14/h4,6,8-10H,5,7,11H2,1-3H3,(H,19,21,22)
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n/an/a 1.59E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340506
PNG
(1-[1-(cyclopropylmethyl)-3-[2-fluoro-3-(1-methylpy...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(-c3cnn(C)c3)c1F)nn2CC1CC1
Show InChI InChI=1S/C22H25FN6O/c1-14(30)28-9-8-20-18(13-28)22(26-29(20)11-15-6-7-15)25-19-5-3-4-17(21(19)23)16-10-24-27(2)12-16/h3-5,10,12,15H,6-9,11,13H2,1-2H3,(H,25,26)
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n/an/a 2.84E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340510
PNG
(2-[[5-acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(-c3cnn(C)c3)c1C#N)nn2CC1CC1
Show InChI InChI=1S/C23H25N7O/c1-15(31)29-9-8-22-20(14-29)23(27-30(22)12-16-6-7-16)26-21-5-3-4-18(19(21)10-24)17-11-25-28(2)13-17/h3-5,11,13,16H,6-9,12,14H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340513
PNG
(US9763922, Example 44)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccccc1)nn2CC1CC1
Show InChI InChI=1S/C18H22N4O/c1-13(23)21-10-9-17-16(12-21)18(19-15-5-3-2-4-6-15)20-22(17)11-14-7-8-14/h2-6,14H,7-12H2,1H3,(H,19,20)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340515
PNG
(US9763922, Example 46)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)S(C)(=O)=O)nn2CC1CC1
Show InChI InChI=1S/C19H24N4O3S/c1-13(24)22-9-8-18-17(12-22)19(21-23(18)11-14-6-7-14)20-15-4-3-5-16(10-15)27(2,25)26/h3-5,10,14H,6-9,11-12H2,1-2H3,(H,20,21)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340517
PNG
(7-[[5-acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-...)
Show SMILES CN1CCc2ccc(Nc3nn(CC4CC4)c4CCN(Cc34)C(C)=O)cc2C1=O
Show InChI InChI=1S/C22H27N5O2/c1-14(28)26-10-8-20-19(13-26)21(24-27(20)12-15-3-4-15)23-17-6-5-16-7-9-25(2)22(29)18(16)11-17/h5-6,11,15H,3-4,7-10,12-13H2,1-2H3,(H,23,24)
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n/an/a 50n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340520
PNG
(US9763922, Example 51)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2C1CCOC1
Show InChI InChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340531
PNG
(1-[1-(cyclopropylmethyl)-3-[3-[3-(hydroxymethyl)ph...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccc(CO)cc1)nn2CC1CC1
Show InChI InChI=1S/C25H28N4O2/c1-17(31)28-12-11-24-23(15-28)25(27-29(24)14-18-5-6-18)26-22-4-2-3-21(13-22)20-9-7-19(16-30)8-10-20/h2-4,7-10,13,18,30H,5-6,11-12,14-16H2,1H3,(H,26,27)
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n/an/a 1.02E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50200430
PNG
(CHEMBL3893541 | US9763922, Example 63)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cccnc1)nn2CC1CC1
Show InChI InChI=1S/C23H25N5O/c1-16(29)27-11-9-22-21(15-27)23(26-28(22)14-17-7-8-17)25-20-6-2-4-18(12-20)19-5-3-10-24-13-19/h2-6,10,12-13,17H,7-9,11,14-15H2,1H3,(H,25,26)
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n/an/a 1.16E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340535
PNG
(US9763922, Example 66)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cccc(c1)C(C)(C)O)nn2CC1CC1
Show InChI InChI=1S/C27H32N4O2/c1-18(32)30-13-12-25-24(17-30)26(29-31(25)16-19-10-11-19)28-23-9-5-7-21(15-23)20-6-4-8-22(14-20)27(2,3)33/h4-9,14-15,19,33H,10-13,16-17H2,1-3H3,(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50200429
PNG
(CHEMBL3981511 | US9763922, Example 67)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2CC1CC1
Show InChI InChI=1S/C22H26N6O/c1-15(29)27-9-8-21-20(14-27)22(25-28(21)12-16-6-7-16)24-19-5-3-4-17(10-19)18-11-23-26(2)13-18/h3-5,10-11,13,16H,6-9,12,14H2,1-2H3,(H,24,25)
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n/an/a 2.11E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340538
PNG
(US9763922, Example 69)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccccc1F)nn2CC1CC1
Show InChI InChI=1S/C24H25FN4O/c1-16(30)28-12-11-23-21(15-28)24(27-29(23)14-17-9-10-17)26-19-6-4-5-18(13-19)20-7-2-3-8-22(20)25/h2-8,13,17H,9-12,14-15H2,1H3,(H,26,27)
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n/an/a 1.97E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50200390
PNG
(CHEMBL3892467 | US9763922, Example 70)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn[nH]c1)nn2CC1CC1
Show InChI InChI=1S/C21H24N6O/c1-14(28)26-8-7-20-19(13-26)21(25-27(20)12-15-5-6-15)24-18-4-2-3-16(9-18)17-10-22-23-11-17/h2-4,9-11,15H,5-8,12-13H2,1H3,(H,22,23)(H,24,25)
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n/an/a 2.63E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340550
PNG
(1-[1-methyl-3-(3-thiazol-5-yl-anilino)-6,7-dihydro...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cncs1)nn2C
Show InChI InChI=1S/C18H19N5OS/c1-12(24)23-7-6-16-15(10-23)18(21-22(16)2)20-14-5-3-4-13(8-14)17-9-19-11-25-17/h3-5,8-9,11H,6-7,10H2,1-2H3,(H,20,21)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340551
PNG
(US9763922, Example 81)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2C
Show InChI InChI=1S/C19H22N6O/c1-13(26)25-8-7-18-17(12-25)19(22-24(18)3)21-16-6-4-5-14(9-16)15-10-20-23(2)11-15/h4-6,9-11H,7-8,12H2,1-3H3,(H,21,22)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340552
PNG
(US9763922, Example 82)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn[nH]c1)nn2C
Show InChI InChI=1S/C18H20N6O/c1-12(25)24-7-6-17-16(11-24)18(22-23(17)2)21-15-5-3-4-13(8-15)14-9-19-20-10-14/h3-5,8-10H,6-7,11H2,1-2H3,(H,19,20)(H,21,22)
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n/an/a 5.38E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340554
PNG
(US9763922, Example 84)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2CCC(F)(F)F
Show InChI InChI=1S/C21H23F3N6O/c1-14(31)29-8-6-19-18(13-29)20(27-30(19)9-7-21(22,23)24)26-17-5-3-4-15(10-17)16-11-25-28(2)12-16/h3-5,10-12H,6-9,13H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340556
PNG
(US9763922, Example 86)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2CC1COC1
Show InChI InChI=1S/C22H26N6O2/c1-15(29)27-7-6-21-20(12-27)22(25-28(21)10-16-13-30-14-16)24-19-5-3-4-17(8-19)18-9-23-26(2)11-18/h3-5,8-9,11,16H,6-7,10,12-14H2,1-2H3,(H,24,25)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340567
PNG
(US9763922, Example 96)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1ccnn1C)nn2CC1CC1
Show InChI InChI=1S/C22H26N6O/c1-15(29)27-12-10-21-19(14-27)22(25-28(21)13-16-3-4-16)24-18-7-5-17(6-8-18)20-9-11-23-26(20)2/h5-9,11,16H,3-4,10,12-14H2,1-2H3,(H,24,25)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340567
PNG
(US9763922, Example 96)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1ccnn1C)nn2CC1CC1
Show InChI InChI=1S/C22H26N6O/c1-15(29)27-12-10-21-19(14-27)22(25-28(21)13-16-3-4-16)24-18-7-5-17(6-8-18)20-9-11-23-26(20)2/h5-9,11,16H,3-4,10,12-14H2,1-2H3,(H,24,25)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340586
PNG
(1-[3-[4-(2-fluorophenyl)anilino]-1-methyl-6,7-dihy...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1ccccc1F)nn2C
Show InChI InChI=1S/C21H21FN4O/c1-14(27)26-12-11-20-18(13-26)21(24-25(20)2)23-16-9-7-15(8-10-16)17-5-3-4-6-19(17)22/h3-10H,11-13H2,1-2H3,(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340590
PNG
(US9763922, Example 119)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cccnc1)nn2C
Show InChI InChI=1S/C20H21N5O/c1-14(26)25-11-9-19-18(13-25)20(23-24(19)2)22-17-7-5-15(6-8-17)16-4-3-10-21-12-16/h3-8,10,12H,9,11,13H2,1-2H3,(H,22,23)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340594
PNG
(US9763922, Example 123)
Show SMILES CCn1cc(cn1)-c1ccc(Nc2nn(C)c3CCN(Cc23)C(C)=O)cc1
Show InChI InChI=1S/C20H24N6O/c1-4-26-12-16(11-21-26)15-5-7-17(8-6-15)22-20-18-13-25(14(2)27)10-9-19(18)24(3)23-20/h5-8,11-12H,4,9-10,13H2,1-3H3,(H,22,23)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340596
PNG
(US9763922, Example 125)
Show SMILES COc1ccc(cc1)-c1ccc(Nc2nn(C)c3CCN(Cc23)C(C)=O)cc1
Show InChI InChI=1S/C22H24N4O2/c1-15(27)26-13-12-21-20(14-26)22(24-25(21)2)23-18-8-4-16(5-9-18)17-6-10-19(28-3)11-7-17/h4-11H,12-14H2,1-3H3,(H,23,24)
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n/an/a 3.53E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340603
PNG
(US9763922, Example 132)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cccc(Cl)c1)nn2C
Show InChI InChI=1S/C21H21ClN4O/c1-14(27)26-11-10-20-19(13-26)21(24-25(20)2)23-18-8-6-15(7-9-18)16-4-3-5-17(22)12-16/h3-9,12H,10-11,13H2,1-2H3,(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340606
PNG
(US9763922, Example 135)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1ccc(cc1)C(N)=O)nn2C
Show InChI InChI=1S/C22H23N5O2/c1-14(28)27-12-11-20-19(13-27)22(25-26(20)2)24-18-9-7-16(8-10-18)15-3-5-17(6-4-15)21(23)29/h3-10H,11-13H2,1-2H3,(H2,23,29)(H,24,25)
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n/an/a 4.66E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340612
PNG
(US9763922, Example 141)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cccc(OC(F)(F)F)c1)nn2C
Show InChI InChI=1S/C22H21F3N4O2/c1-14(30)29-11-10-20-19(13-29)21(27-28(20)2)26-17-8-6-15(7-9-17)16-4-3-5-18(12-16)31-22(23,24)25/h3-9,12H,10-11,13H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340615
PNG
(US9763922, Example 144)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1ccc(NS(C)(=O)=O)cc1)nn2C
Show InChI InChI=1S/C22H25N5O3S/c1-15(28)27-13-12-21-20(14-27)22(24-26(21)2)23-18-8-4-16(5-9-18)17-6-10-19(11-7-17)25-31(3,29)30/h4-11,25H,12-14H2,1-3H3,(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340628
PNG
(US9763922, Example 157)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1ccc(N)nc1)nn2C
Show InChI InChI=1S/C20H22N6O/c1-13(27)26-10-9-18-17(12-26)20(24-25(18)2)23-16-6-3-14(4-7-16)15-5-8-19(21)22-11-15/h3-8,11H,9-10,12H2,1-2H3,(H2,21,22)(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340629
PNG
(US9763922, Example 158)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cncc(c1)S(C)(=O)=O)nn2C
Show InChI InChI=1S/C21H23N5O3S/c1-14(27)26-9-8-20-19(13-26)21(24-25(20)2)23-17-6-4-15(5-7-17)16-10-18(12-22-11-16)30(3,28)29/h4-7,10-12H,8-9,13H2,1-3H3,(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340639
PNG
(1-[1-methyl-3-[4-[1-[2-(methylamino)ethyl]pyrazol-...)
Show SMILES CNCCn1cc(cn1)-c1ccc(Nc2nn(C)c3CCN(Cc23)C(C)=O)cc1
Show InChI InChI=1S/C21H27N7O/c1-15(29)27-10-8-20-19(14-27)21(25-26(20)3)24-18-6-4-16(5-7-18)17-12-23-28(13-17)11-9-22-2/h4-7,12-13,22H,8-11,14H2,1-3H3,(H,24,25)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340645
PNG
(US9763922, Example 172)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2CCC(F)(F)F
Show InChI InChI=1S/C21H23F3N6O/c1-14(31)29-9-7-19-18(13-29)20(27-30(19)10-8-21(22,23)24)26-17-5-3-15(4-6-17)16-11-25-28(2)12-16/h3-6,11-12H,7-10,13H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340647
PNG
(US9763922, Example 174)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2CC(F)(F)F
Show InChI InChI=1S/C20H21F3N6O/c1-13(30)28-8-7-18-17(11-28)19(26-29(18)12-20(21,22)23)25-16-5-3-14(4-6-16)15-9-24-27(2)10-15/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340649
PNG
(US9763922, Example 176)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2CC1CC1(F)F
Show InChI InChI=1S/C22H24F2N6O/c1-14(31)29-8-7-20-19(13-29)21(27-30(20)12-17-9-22(17,23)24)26-18-5-3-15(4-6-18)16-10-25-28(2)11-16/h3-6,10-11,17H,7-9,12-13H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50200427
PNG
(CHEMBL3924330 | US9763922, Example 179)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2[C@H]1CCOC1
Show InChI InChI=1S/C22H26N6O2/c1-15(29)27-9-7-21-20(13-27)22(25-28(21)19-8-10-30-14-19)24-18-5-3-16(4-6-18)17-11-23-26(2)12-17/h3-6,11-12,19H,7-10,13-14H2,1-2H3,(H,24,25)/t19-/m0/s1
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n/an/a 5.18E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340659
PNG
(1-[3-[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]an...)
Show SMILES CN(C)CCn1cc(cn1)-c1ccc(Nc2nn(C)c3CCN(Cc23)C(C)=O)cc1
Show InChI InChI=1S/C22H29N7O/c1-16(30)28-10-9-21-20(15-28)22(25-27(21)4)24-19-7-5-17(6-8-19)18-13-23-29(14-18)12-11-26(2)3/h5-8,13-14H,9-12,15H2,1-4H3,(H,24,25)
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n/an/a 6.75E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340662
PNG
(US9763922, Example 189)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1cnco1
Show InChI InChI=1S/C19H21N5O2/c1-13-4-3-5-15(8-13)21-19-17-11-23(14(2)25)7-6-18(17)24(22-19)10-16-9-20-12-26-16/h3-5,8-9,12H,6-7,10-11H2,1-2H3,(H,21,22)
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n/an/a 200n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340666
PNG
(US9763922, Example 193)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CCc1ccncc1
Show InChI InChI=1S/C22H25N5O/c1-16-4-3-5-19(14-16)24-22-20-15-26(17(2)28)12-9-21(20)27(25-22)13-8-18-6-10-23-11-7-18/h3-7,10-11,14H,8-9,12-13,15H2,1-2H3,(H,24,25)
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n/an/a 1.25E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50200433
PNG
(CHEMBL3916599 | US9763922, Example 202)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1ccncc1
Show InChI InChI=1S/C21H23N5O/c1-15-4-3-5-18(12-15)23-21-19-14-25(16(2)27)11-8-20(19)26(24-21)13-17-6-9-22-10-7-17/h3-7,9-10,12H,8,11,13-14H2,1-2H3,(H,23,24)
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n/an/a 5.19E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340680
PNG
(US9763922, Example 207)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CCCC#N
Show InChI InChI=1S/C19H23N5O/c1-14-6-5-7-16(12-14)21-19-17-13-23(15(2)25)11-8-18(17)24(22-19)10-4-3-9-20/h5-7,12H,3-4,8,10-11,13H2,1-2H3,(H,21,22)
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n/an/a>1.97E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340697
PNG
(1-(1-(cyclopropylmethyl)-3-((3-(trifluoromethyl)ph...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)C(F)(F)F)nn2CC1CC1
Show InChI InChI=1S/C19H21F3N4O/c1-12(27)25-8-7-17-16(11-25)18(24-26(17)10-13-5-6-13)23-15-4-2-3-14(9-15)19(20,21)22/h2-4,9,13H,5-8,10-11H2,1H3,(H,23,24)
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM340697
PNG
(1-(1-(cyclopropylmethyl)-3-((3-(trifluoromethyl)ph...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)C(F)(F)F)nn2CC1CC1
Show InChI InChI=1S/C19H21F3N4O/c1-12(27)25-8-7-17-16(11-25)18(24-26(17)10-13-5-6-13)23-15-4-2-3-14(9-15)19(20,21)22/h2-4,9,13H,5-8,10-11H2,1H3,(H,23,24)
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n/an/a 5.11E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
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