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Patent code US9763922

Compile Data Set for Download or QSAR

Found 595 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM340748
PNG
(US9763922, Example 274)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H31F3N8O2/c1-15(38)35-7-4-17(5-8-35)37-23-6-9-36(26(39)30-2)14-20(23)25(33-37)32-22-11-19(24(28)29)18(10-21(22)27)16-12-31-34(3)13-16/h10-13,17,24H,4-9,14H2,1-3H3,(H,30,39)(H,32,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340734
PNG
(3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C24H28F3N7O2/c1-28-24(35)33-6-3-21-18(13-33)23(31-34(21)15-4-7-36-8-5-15)30-20-10-17(22(26)27)16(9-19(20)25)14-11-29-32(2)12-14/h9-12,15,22H,3-8,13H2,1-2H3,(H,28,35)(H,30,31)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340747
PNG
(3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H28F3N7O3S/c1-28-24(35)33-6-3-21-18(13-33)23(31-34(21)15-4-7-38(36,37)8-5-15)30-20-10-17(22(26)27)16(9-19(20)25)14-11-29-32(2)12-14/h9-12,15,22H,3-8,13H2,1-2H3,(H,28,35)(H,30,31)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340716
PNG
(1-[3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyraz...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C24H27F3N6O2/c1-14(34)32-6-3-22-19(13-32)24(30-33(22)16-4-7-35-8-5-16)29-21-10-18(23(26)27)17(9-20(21)25)15-11-28-31(2)12-15/h9-12,16,23H,3-8,13H2,1-2H3,(H,29,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340746
PNG
(US9763922, Example 272)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccc(nc1)C(=O)NC)nn2C1CCOCC1
Show InChI InChI=1S/C27H30F3N7O3/c1-31-26(38)21-4-3-15(13-33-21)17-11-20(28)22(12-18(17)24(29)30)34-25-19-14-36(27(39)32-2)8-5-23(19)37(35-25)16-6-9-40-10-7-16/h3-4,11-13,16,24H,5-10,14H2,1-2H3,(H,31,38)(H,32,39)(H,34,35)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340740
PNG
(US9763922, Example 266)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccnc(OC)c1)nn2C1CCOCC1
Show InChI InChI=1S/C26H29F3N6O3/c1-30-26(36)34-8-4-22-19(14-34)25(33-35(22)16-5-9-38-10-6-16)32-21-13-18(24(28)29)17(12-20(21)27)15-3-7-31-23(11-15)37-2/h3,7,11-13,16,24H,4-6,8-10,14H2,1-2H3,(H,30,36)(H,32,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340730
PNG
(3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(F)c(Nc2nn(C3CCOCC3)c3CCN(Cc23)C(N)=O)cc1C(F)F
Show InChI InChI=1S/C23H26F3N7O2/c1-31-11-13(10-28-31)15-8-18(24)19(9-16(15)21(25)26)29-22-17-12-32(23(27)34)5-2-20(17)33(30-22)14-3-6-35-7-4-14/h8-11,14,21H,2-7,12H2,1H3,(H2,27,34)(H,29,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340731
PNG
(US9763922, Example 257)
Show SMILES Cn1cc(cn1)-c1cc(F)c(Nc2nn([C@H]3CCOC3)c3CCN(Cc23)C(N)=O)cc1C(F)F
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-12(8-27-30)14-6-17(23)18(7-15(14)20(24)25)28-21-16-10-31(22(26)33)4-2-19(16)32(29-21)13-3-5-34-11-13/h6-9,13,20H,2-5,10-11H2,1H3,(H2,26,33)(H,28,29)/t13-/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340745
PNG
(US9763922, Example 271)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(cc(c1)S(=O)(=O)N(C)C)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C25H34N8O4S/c1-26-25(34)32-8-5-23-22(16-32)24(29-33(23)20-6-9-37-10-7-20)28-19-11-17(18-14-27-31(4)15-18)12-21(13-19)38(35,36)30(2)3/h11-15,20H,5-10,16H2,1-4H3,(H,26,34)(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340735
PNG
(US9763922, Example 261)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2[C@H]1CCOC1
Show InChI InChI=1S/C23H26F3N7O2/c1-27-23(34)32-5-3-20-17(11-32)22(30-33(20)14-4-6-35-12-14)29-19-8-16(21(25)26)15(7-18(19)24)13-9-28-31(2)10-13/h7-10,14,21H,3-6,11-12H2,1-2H3,(H,27,34)(H,29,30)/t14-/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340742
PNG
(US9763922, Example 268)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C23H27F2N7O2/c1-26-23(33)31-6-3-21-17(13-31)22(29-32(21)15-4-7-34-8-5-15)28-20-10-18(24)16(9-19(20)25)14-11-27-30(2)12-14/h9-12,15H,3-8,13H2,1-2H3,(H,26,33)(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340726
PNG
(1-[3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyraz...)
Show SMILES CCC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C25H29F3N6O2/c1-3-23(35)33-7-4-22-19(14-33)25(31-34(22)16-5-8-36-9-6-16)30-21-11-18(24(27)28)17(10-20(21)26)15-12-29-32(2)13-15/h10-13,16,24H,3-9,14H2,1-2H3,(H,30,31)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340743
PNG
(US9763922, Example 269)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C#N)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C24H27FN8O2/c1-27-24(34)32-6-3-22-19(14-32)23(30-33(22)17-4-7-35-8-5-17)29-21-9-15(11-26)18(10-20(21)25)16-12-28-31(2)13-16/h9-10,12-13,17H,3-8,14H2,1-2H3,(H,27,34)(H,29,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340739
PNG
(US9763922, Example 265)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C1CCOCC1
Show InChI InChI=1S/C24H27F4N7O2/c1-29-23(36)34-8-5-20-17(13-34)22(32-35(20)15-6-9-37-10-7-15)30-19-4-3-14(11-18(19)25)16-12-33(2)31-21(16)24(26,27)28/h3-4,11-12,15H,5-10,13H2,1-2H3,(H,29,36)(H,30,32)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340715
PNG
(US9763922, Example 241)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOC1
Show InChI InChI=1S/C23H25F3N6O2/c1-13(33)31-5-3-21-18(11-31)23(29-32(21)15-4-6-34-12-15)28-20-8-17(22(25)26)16(7-19(20)24)14-9-27-30(2)10-14/h7-10,15,22H,3-6,11-12H2,1-2H3,(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340698
PNG
(1-[3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyraz...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1COC1
Show InChI InChI=1S/C22H23F3N6O2/c1-12(32)30-4-3-20-17(9-30)22(28-31(20)14-10-33-11-14)27-19-6-16(21(24)25)15(5-18(19)23)13-7-26-29(2)8-13/h5-8,14,21H,3-4,9-11H2,1-2H3,(H,27,28)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340763
PNG
(US9763922, Example 289)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(c1)C(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H26F2N6O2/c1-14(32)30-7-5-21-20(12-30)23(28-31(21)17-6-8-33-13-17)27-16-3-4-18(19(9-16)22(24)25)15-10-26-29(2)11-15/h3-4,9-11,17,22H,5-8,12-13H2,1-2H3,(H,27,28)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM341774
PNG
(US9763922, Example 310)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1c[nH]nc1C(F)(F)F)nn2C1CCOC1
Show InChI InChI=1S/C22H22F4N6O2/c1-12(33)31-6-4-19-16(10-31)21(30-32(19)14-5-7-34-11-14)28-18-3-2-13(8-17(18)23)15-9-27-29-20(15)22(24,25)26/h2-3,8-9,14H,4-7,10-11H2,1H3,(H,27,29)(H,28,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340529
PNG
(US9763922, Example 60)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2C1CC1
Show InChI InChI=1S/C21H24N6O/c1-14(28)26-10-9-20-19(13-26)21(24-27(20)18-7-8-18)23-17-5-3-15(4-6-17)16-11-22-25(2)12-16/h3-6,11-12,18H,7-10,13H2,1-2H3,(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340546
PNG
(1-(1-(cyclopropylmethyl)-3-((2′,3′,4&#...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)C1=CCCCC1)nn2CC1CC1
Show InChI InChI=1S/C24H30N4O/c1-17(29)27-13-12-23-22(16-27)24(26-28(23)15-18-10-11-18)25-21-9-5-8-20(14-21)19-6-3-2-4-7-19/h5-6,8-9,14,18H,2-4,7,10-13,15-16H2,1H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340773
PNG
(US9763922, Example 297)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2[C@@H]1CCOC1
Show InChI InChI=1S/C23H24F4N6O2/c1-13(34)32-7-5-20-17(11-32)22(30-33(20)15-6-8-35-12-15)28-19-4-3-14(9-18(19)24)16-10-31(2)29-21(16)23(25,26)27/h3-4,9-10,15H,5-8,11-12H2,1-2H3,(H,28,30)/t15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340509
PNG
(US9763922, Example 40)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(ccc1F)-c1cnn(C)c1)nn2CC1CC1
Show InChI InChI=1S/C22H25FN6O/c1-14(30)28-8-7-21-18(13-28)22(26-29(21)11-15-3-4-15)25-20-9-16(5-6-19(20)23)17-10-24-27(2)12-17/h5-6,9-10,12,15H,3-4,7-8,11,13H2,1-2H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340545
PNG
(US9763922, Example 76)
Show SMILES CCC(O)c1cccc(c1)-c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1
Show InChI InChI=1S/C27H32N4O2/c1-3-26(33)22-8-4-6-20(14-22)21-7-5-9-23(15-21)28-27-24-17-30(18(2)32)13-12-25(24)31(29-27)16-19-10-11-19/h4-9,14-15,19,26,33H,3,10-13,16-17H2,1-2H3,(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340555
PNG
(US9763922, Example 85)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2CC1CC1(F)F
Show InChI InChI=1S/C22H24F2N6O/c1-14(31)29-7-6-20-19(13-29)21(27-30(20)12-17-9-22(17,23)24)26-18-5-3-4-15(8-18)16-10-25-28(2)11-16/h3-5,8,10-11,17H,6-7,9,12-13H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340504
PNG
(US9763922, Example 35)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn(C)nc1C(C)(F)F)nn2C
Show InChI InChI=1S/C21H24F2N6O/c1-13(30)29-9-8-18-17(12-29)20(26-28(18)4)24-15-7-5-6-14(10-15)16-11-27(3)25-19(16)21(2,22)23/h5-7,10-11H,8-9,12H2,1-4H3,(H,24,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340528
PNG
(1-(1-cyclopropyl-3-((3-(1-methyl-1H-pyrazol-4-yl)p...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2C1CC1
Show InChI InChI=1S/C21H24N6O/c1-14(28)26-9-8-20-19(13-26)21(24-27(20)18-6-7-18)23-17-5-3-4-15(10-17)16-11-22-25(2)12-16/h3-5,10-12,18H,6-9,13H2,1-2H3,(H,23,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340531
PNG
(1-[1-(cyclopropylmethyl)-3-[3-[3-(hydroxymethyl)ph...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccc(CO)cc1)nn2CC1CC1
Show InChI InChI=1S/C25H28N4O2/c1-17(31)28-12-11-24-23(15-28)25(27-29(24)14-18-5-6-18)26-22-4-2-3-21(13-22)20-9-7-19(16-30)8-10-20/h2-4,7-10,13,18,30H,5-6,11-12,14-16H2,1H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50200377
PNG
(CHEMBL3962542 | US9763922, Example 64)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccncc1)nn2CC1CC1
Show InChI InChI=1S/C23H25N5O/c1-16(29)27-12-9-22-21(15-27)23(26-28(22)14-17-5-6-17)25-20-4-2-3-19(13-20)18-7-10-24-11-8-18/h2-4,7-8,10-11,13,17H,5-6,9,12,14-15H2,1H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340583
PNG
(US9763922, Example 112)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cn(C)nc1C(F)(F)F)nn2C
Show InChI InChI=1S/C20H21F3N6O/c1-12(30)29-9-8-17-16(11-29)19(26-28(17)3)24-14-6-4-13(5-7-14)15-10-27(2)25-18(15)20(21,22)23/h4-7,10H,8-9,11H2,1-3H3,(H,24,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340507
PNG
(US9763922, Example 38)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(F)c(c1)-c1cnn(C)c1)nn2CC1CC1
Show InChI InChI=1S/C22H25FN6O/c1-14(30)28-8-7-21-19(13-28)22(26-29(21)11-15-3-4-15)25-17-5-6-20(23)18(9-17)16-10-24-27(2)12-16/h5-6,9-10,12,15H,3-4,7-8,11,13H2,1-2H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340521
PNG
(US9763922, Example 52)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(F)c1)nn2C1CCOC1
Show InChI InChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-19(12-28)22(26-29(21)17-6-8-31-13-17)25-16-3-4-18(20(23)9-16)15-10-24-27(2)11-15/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340524
PNG
(1-(3-((2-fluoro-4-(1-methyl-3-(trifluoromethyl)-1H...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H24F4N6O2/c1-13(34)32-7-5-20-17(11-32)22(30-33(20)15-6-8-35-12-15)28-19-4-3-14(9-18(19)24)16-10-31(2)29-21(16)23(25,26)27/h3-4,9-10,15H,5-8,11-12H2,1-2H3,(H,28,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340700
PNG
(US9763922, Example 226)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(c1)C(F)F)nn2C1COC1
Show InChI InChI=1S/C22H24F2N6O2/c1-13(31)29-6-5-20-19(10-29)22(27-30(20)16-11-32-12-16)26-15-3-4-17(18(7-15)21(23)24)14-8-25-28(2)9-14/h3-4,7-9,16,21H,5-6,10-12H2,1-2H3,(H,26,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340490
PNG
(US9763922, Example 21)
Show SMILES CNC1=C(CN(CC1)C(C)=O)C(=N)Nc1cc(C)cc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C20H26N6O/c1-13-7-15(16-10-23-25(4)11-16)9-17(8-13)24-20(21)18-12-26(14(2)27)6-5-19(18)22-3/h7-11,22H,5-6,12H2,1-4H3,(H2,21,24)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340503
PNG
(1-[3-[2-fluoro-4-[1-methyl-3-(trifluoromethyl)pyra...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C
Show InChI InChI=1S/C20H20F4N6O/c1-11(31)30-7-6-17-14(10-30)19(27-29(17)3)25-16-5-4-12(8-15(16)21)13-9-28(2)26-18(13)20(22,23)24/h4-5,8-9H,6-7,10H2,1-3H3,(H,25,27)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340756
PNG
(US9763922, Example 282)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(cc(c1)C(F)(F)F)-c1cnn(C)c1)nn2C1CCOC1
Show InChI InChI=1S/C23H25F3N6O2/c1-14(33)31-5-3-21-20(12-31)22(29-32(21)19-4-6-34-13-19)28-18-8-15(16-10-27-30(2)11-16)7-17(9-18)23(24,25)26/h7-11,19H,3-6,12-13H2,1-2H3,(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340534
PNG
(US9763922, Example 65)
Show SMILES CC(O)c1cccc(c1)-c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1
Show InChI InChI=1S/C26H30N4O2/c1-17(31)20-5-3-6-21(13-20)22-7-4-8-23(14-22)27-26-24-16-29(18(2)32)12-11-25(24)30(28-26)15-19-9-10-19/h3-8,13-14,17,19,31H,9-12,15-16H2,1-2H3,(H,27,28)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340535
PNG
(US9763922, Example 66)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cccc(c1)C(C)(C)O)nn2CC1CC1
Show InChI InChI=1S/C27H32N4O2/c1-18(32)30-13-12-25-24(17-30)26(29-31(25)16-19-10-11-19)28-23-9-5-7-21(15-23)20-6-4-8-22(14-20)27(2,3)33/h4-9,14-15,19,33H,10-13,16-17H2,1-3H3,(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50200390
PNG
(CHEMBL3892467 | US9763922, Example 70)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn[nH]c1)nn2CC1CC1
Show InChI InChI=1S/C21H24N6O/c1-14(28)26-8-7-20-19(13-26)21(25-27(20)12-15-5-6-15)24-18-4-2-3-16(9-18)17-10-22-23-11-17/h2-4,9-11,15H,5-8,12-13H2,1H3,(H,22,23)(H,24,25)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340525
PNG
(US9763922, Example 56)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cn(C)nc1C(F)(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H25F3N6O2/c1-14(33)31-9-7-20-19(12-31)22(29-32(20)17-8-10-34-13-17)27-16-5-3-15(4-6-16)18-11-30(2)28-21(18)23(24,25)26/h3-6,11,17H,7-10,12-13H2,1-2H3,(H,27,29)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340526
PNG
(US9763922, Example 57)
Show SMILES CN\C=C(/C(=N)C(F)(F)F)c1ccc(NC(=N)C2=C(CCN(C2)C(C)=O)NC2CCOC2)cn1
Show InChI InChI=1S/C22H28F3N7O2/c1-13(33)32-7-5-19(30-15-6-8-34-12-15)17(11-32)21(27)31-14-3-4-18(29-9-14)16(10-28-2)20(26)22(23,24)25/h3-4,9-10,15,26,28,30H,5-8,11-12H2,1-2H3,(H2,27,31)/b16-10-,26-20?
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50200429
PNG
(CHEMBL3981511 | US9763922, Example 67)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2CC1CC1
Show InChI InChI=1S/C22H26N6O/c1-15(29)27-9-8-21-20(14-27)22(25-28(21)12-16-6-7-16)24-19-5-3-4-17(10-19)18-11-23-26(2)13-18/h3-5,10-11,13,16H,6-9,12,14H2,1-2H3,(H,24,25)
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US Patent
n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340741
PNG
(US9763922, Example 267)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1C)nn2C1CCOCC1
Show InChI InChI=1S/C24H30FN7O2/c1-15-18(13-27-30(15)3)16-4-5-21(20(25)12-16)28-23-19-14-31(24(33)26-2)9-6-22(19)32(29-23)17-7-10-34-11-8-17/h4-5,12-13,17H,6-11,14H2,1-3H3,(H,26,33)(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340777
PNG
(US9763922, Example 301)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C1COC1
Show InChI InChI=1S/C22H22F4N6O2/c1-12(33)31-6-5-19-16(9-31)21(29-32(19)14-10-34-11-14)27-18-4-3-13(7-17(18)23)15-8-30(2)28-20(15)22(24,25)26/h3-4,7-8,14H,5-6,9-11H2,1-2H3,(H,27,29)
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n/an/a 12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340717
PNG
(US9763922, Example 243)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)F)nn2C1CCOCC1
Show InChI InChI=1S/C24H27F3N6O2/c1-14(34)32-8-5-21-18(13-32)24(30-33(21)16-6-9-35-10-7-16)28-20-4-3-15(11-19(20)25)17-12-31(2)29-22(17)23(26)27/h3-4,11-12,16,23H,5-10,13H2,1-2H3,(H,28,30)
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340771
PNG
(US9763922, Example 295)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1C(F)(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H25F3N6O2/c1-14(33)31-9-7-20-19(12-31)22(29-32(20)17-8-10-34-13-17)28-16-5-3-15(4-6-16)18-11-27-30(2)21(18)23(24,25)26/h3-6,11,17H,7-10,12-13H2,1-2H3,(H,28,29)
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340713
PNG
(US9763922, Example 239)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C#N)c(cc1F)-c1cnn(C)c1)nn2C1CCOC1
Show InChI InChI=1S/C23H24FN7O2/c1-14(32)30-5-3-22-19(12-30)23(28-31(22)17-4-6-33-13-17)27-21-7-15(9-25)18(8-20(21)24)16-10-26-29(2)11-16/h7-8,10-11,17H,3-6,12-13H2,1-2H3,(H,27,28)
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n/an/a 15n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340738
PNG
(US9763922, Example 264)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(F)c1F)nn2C1CCOCC1
Show InChI InChI=1S/C23H27F2N7O2/c1-26-23(33)31-8-5-19-17(13-31)22(29-32(19)15-6-9-34-10-7-15)28-18-4-3-16(20(24)21(18)25)14-11-27-30(2)12-14/h3-4,11-12,15H,5-10,13H2,1-2H3,(H,26,33)(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340774
PNG
(US9763922, Example 298)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2[C@H]1CCOC1
Show InChI InChI=1S/C23H24F4N6O2/c1-13(34)32-7-5-20-17(11-32)22(30-33(20)15-6-8-35-12-15)28-19-4-3-14(9-18(19)24)16-10-31(2)29-21(16)23(25,26)27/h3-4,9-10,15H,5-8,11-12H2,1-2H3,(H,28,30)/t15-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340770
PNG
(US9763922, Example 294)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(Cl)c1)nn2C1CCOC1
Show InChI InChI=1S/C22H25ClN6O2/c1-14(30)28-7-5-21-19(12-28)22(26-29(21)17-6-8-31-13-17)25-16-3-4-18(20(23)9-16)15-10-24-27(2)11-15/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)
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n/an/a 15n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%