BindingDB logo
myBDB logout

Patent code US9765056

Compile Data Set for Download or QSAR
Found 173 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341016
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)CC1
Show InChI InChI=1S/C43H43BrN6O3/c1-29-22-33(42(52)50(35-9-12-38(51)13-10-35)36-11-15-40-31(24-36)16-17-46(40)3)27-48(29)41-25-34(44)8-14-39(41)43(53)49-26-32-7-5-4-6-30(32)23-37(49)28-47-20-18-45(2)19-21-47/h4-17,22,24-25,27,37,51H,18-21,23,26,28H2,1-3H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341129
PNG
(N-(4-Fluorophenyl)-1-{4-hydroxy-5-methoxy-2-[(3S)-...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccc(O)cc2)c2ccc(F)cc2)c2ccccc12
Show InChI InChI=1S/C44H42FN5O5/c1-46-19-21-47(22-20-46)27-34-23-29-7-3-4-8-30(29)26-48(34)43(53)37-24-41(52)42(55-2)25-40(37)49-28-38(36-9-5-6-10-39(36)49)44(54)50(32-13-11-31(45)12-14-32)33-15-17-35(51)18-16-33/h3-18,24-25,28,34,51-52H,19-23,26-27H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341098
PNG
(1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C44H43N5O5/c1-45-20-22-46(23-21-45)28-34-24-30-10-6-7-11-31(30)27-47(34)43(52)37-25-41(51)42(54-2)26-40(37)48-29-38(36-14-8-9-15-39(36)48)44(53)49(32-12-4-3-5-13-32)33-16-18-35(50)19-17-33/h3-19,25-26,29,34,50-51H,20-24,27-28H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341040
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C46H43ClN6O3/c1-48-21-23-50(24-22-48)29-37-25-31-7-3-4-8-33(31)28-51(37)45(55)40-17-11-34(47)27-44(40)52-30-41(39-9-5-6-10-43(39)52)46(56)53(35-12-15-38(54)16-13-35)36-14-18-42-32(26-36)19-20-49(42)2/h3-20,26-27,30,37,54H,21-25,28-29H2,1-2H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341126
PNG
(1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc3[nH]ccc3c2)c2ccccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340980
PNG
(N-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-1-(6-{[(3S)...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(F)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H40FN5O5/c1-46-18-20-47(21-19-46)26-34-22-29-6-2-3-7-30(29)25-48(34)43(52)37-23-41-42(55-28-54-41)24-40(37)49-27-38(36-8-4-5-9-39(36)49)44(53)50(32-12-10-31(45)11-13-32)33-14-16-35(51)17-15-33/h2-17,23-24,27,34,51H,18-22,25-26,28H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340977
PNG
(N-(4-Hydroxyphenyl)-N-(4-methylphenyl)-1-(6-{[(3S)...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C45H43N5O5/c1-30-11-13-33(14-12-30)50(34-15-17-36(51)18-16-34)45(53)39-28-49(40-10-6-5-9-37(39)40)41-25-43-42(54-29-55-43)24-38(41)44(52)48-26-32-8-4-3-7-31(32)23-35(48)27-47-21-19-46(2)20-22-47/h3-18,24-25,28,35,51H,19-23,26-27,29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341037
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)CC1
Show InChI InChI=1S/C44H44N6O5/c1-29-20-33(43(52)50(34-8-11-37(51)12-9-34)35-10-13-39-31(22-35)14-15-46(39)3)26-48(29)40-24-42-41(54-28-55-42)23-38(40)44(53)49-25-32-7-5-4-6-30(32)21-36(49)27-47-18-16-45(2)17-19-47/h4-15,20,22-24,26,36,51H,16-19,21,25,27-28H2,1-3H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341032
PNG
(N-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-5-methyl-1-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C41H40ClN5O5/c1-27-19-30(40(49)47(32-9-7-31(42)8-10-32)33-11-13-35(48)14-12-33)24-45(27)37-22-39-38(51-26-52-39)21-36(37)41(50)46-23-29-6-4-3-5-28(29)20-34(46)25-44-17-15-43(2)16-18-44/h3-14,19,21-22,24,34,48H,15-18,20,23,25-26H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341030
PNG
(N,N-bis(4-Hydroxyphenyl)-5-methyl-1-(6-{[(3S)-3-[(...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C41H41N5O6/c1-27-19-30(40(49)46(31-7-11-34(47)12-8-31)32-9-13-35(48)14-10-32)24-44(27)37-22-39-38(51-26-52-39)21-36(37)41(50)45-23-29-6-4-3-5-28(29)20-33(45)25-43-17-15-42(2)16-18-43/h3-14,19,21-22,24,33,47-48H,15-18,20,23,25-26H2,1-2H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341024
PNG
(1-(5-Chloro-4-fluoro-2-{[(3S)-3-[(4-methylpiperazi...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(F)c(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C46H42ClFN6O3/c1-49-19-21-51(22-20-49)28-35-23-30-7-3-4-8-32(30)27-52(35)45(56)38-25-41(48)40(47)26-44(38)53-29-39(37-9-5-6-10-43(37)53)46(57)54(33-11-14-36(55)15-12-33)34-13-16-42-31(24-34)17-18-50(42)2/h3-18,24-26,29,35,55H,19-23,27-28H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340986
PNG
(N,N-bis(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylp...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H41N5O6/c1-45-18-20-46(21-19-45)26-33-22-29-6-2-3-7-30(29)25-47(33)43(52)37-23-41-42(55-28-54-41)24-40(37)48-27-38(36-8-4-5-9-39(36)48)44(53)49(31-10-14-34(50)15-11-31)32-12-16-35(51)17-13-32/h2-17,23-24,27,33,50-51H,18-22,25-26,28H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340982
PNG
(N-(4-Hydroxyphenyl)-N-(1H-indol-5-yl)-1-(6-{[(3S)-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4[nH]ccc4c3)c3ccccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341043
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(4-methylphenyl)-1-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(C)cc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C42H43N5O5/c1-28-8-10-33(11-9-28)47(34-12-14-36(48)15-13-34)41(49)32-20-29(2)45(25-32)38-23-40-39(51-27-52-40)22-37(38)42(50)46-24-31-7-5-4-6-30(31)21-35(46)26-44-18-16-43(3)17-19-44/h4-15,20,22-23,25,35,48H,16-19,21,24,26-27H2,1-3H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341019
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H40ClN5O4/c1-45-20-22-46(23-21-45)27-34-24-29-6-2-3-7-30(29)26-47(34)42(52)38-19-10-31(44)25-41(38)48-28-39(37-8-4-5-9-40(37)48)43(53)49(32-11-15-35(50)16-12-32)33-13-17-36(51)18-14-33/h2-19,25,28,34,50-51H,20-24,26-27H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341104
PNG
(1-{2-[(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroiso...)
Show SMILES OC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C38H31N3O4/c42-25-30-22-26-10-4-5-11-27(26)23-39(30)37(44)33-15-7-9-17-36(33)40-24-34(32-14-6-8-16-35(32)40)38(45)41(28-12-2-1-3-13-28)29-18-20-31(43)21-19-29/h1-21,24,30,42-43H,22-23,25H2/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341036
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)CC1
Show InChI InChI=1S/C43H43ClN6O3/c1-29-22-33(42(52)50(35-9-12-38(51)13-10-35)36-11-15-40-31(24-36)16-17-46(40)3)27-48(29)41-25-34(44)8-14-39(41)43(53)49-26-32-7-5-4-6-30(32)23-37(49)28-47-20-18-45(2)19-21-47/h4-17,22,24-25,27,37,51H,18-21,23,26,28H2,1-3H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341020
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H42ClN5O3/c1-30-11-14-34(15-12-30)50(35-16-18-37(51)19-17-35)44(53)40-29-49(41-10-6-5-9-38(40)41)42-26-33(45)13-20-39(42)43(52)48-27-32-8-4-3-7-31(32)25-36(48)28-47-23-21-46(2)22-24-47/h3-20,26,29,36,51H,21-25,27-28H2,1-2H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341133
PNG
(N-(4-Hydroxyphenyl)-1-{5-methoxy-2-[(3S)-3-[(4-met...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c(c1)-n1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2ccccc12
Show InChI InChI=1S/C47H46N6O4/c1-48-22-24-50(25-23-48)30-37-26-32-8-4-5-9-34(32)29-51(37)46(55)41-18-17-39(57-3)28-45(41)52-31-42(40-10-6-7-11-44(40)52)47(56)53(35-12-15-38(54)16-13-35)36-14-19-43-33(27-36)20-21-49(43)2/h4-21,27-28,31,37,54H,22-26,29-30H2,1-3H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341034
PNG
(N-(4-Hydroxyphenyl)-N-(1H-indol-5-yl)-5-methyl-1-(...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3[nH]ccc3c2)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340978
PNG
(N-Butyl-N-(4-hydroxyphenyl)-1-(6-{[(3S)-3-[(4-meth...)
Show SMILES CCCCN(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)cc1
Show InChI InChI=1S/C42H45N5O5/c1-3-4-17-45(31-13-15-33(48)16-14-31)42(50)36-27-47(37-12-8-7-11-34(36)37)38-24-40-39(51-28-52-40)23-35(38)41(49)46-25-30-10-6-5-9-29(30)22-32(46)26-44-20-18-43(2)19-21-44/h5-16,23-24,27,32,48H,3-4,17-22,25-26,28H2,1-2H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341130
PNG
(1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccc(O)cc2)c2ccc3[nH]ccc3c2)c2ccccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341057
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-...)
Show SMILES Cc1cc(cn1-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C43H41N5O6/c1-28-19-32(42(50)48(33-7-10-36(49)11-8-33)34-9-12-38-30(21-34)13-14-44(38)2)25-46(28)39-23-41-40(53-27-54-41)22-37(39)43(51)47-24-31-6-4-3-5-29(31)20-35(47)26-45-15-17-52-18-16-45/h3-14,19,21-23,25,35,49H,15-18,20,24,26-27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341018
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4[nH]ccc4c3)c3ccccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341132
PNG
(N-Cyclohexyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(C2CCCCC2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C44H49N5O5/c1-45-20-22-46(23-21-45)28-34-24-30-10-6-7-11-31(30)27-47(34)43(52)37-25-41(51)42(54-2)26-40(37)48-29-38(36-14-8-9-15-39(36)48)44(53)49(32-12-4-3-5-13-32)33-16-18-35(50)19-17-33/h6-11,14-19,25-26,29,32,34,50-51H,3-5,12-13,20-24,27-28H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341047
PNG
(N-(1-Ethyl-1H-indol-5-yl)-N-(4-hydroxyphenyl)-1-(6...)
Show SMILES CCn1ccc2cc(ccc12)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)cc1
Show InChI InChI=1S/C48H46N6O5/c1-3-51-19-18-33-25-36(14-17-42(33)51)54(35-12-15-38(55)16-13-35)48(57)41-30-53(43-11-7-6-10-39(41)43)44-27-46-45(58-31-59-46)26-40(44)47(56)52-28-34-9-5-4-8-32(34)24-37(52)29-50-22-20-49(2)21-23-50/h4-19,25-27,30,37,55H,3,20-24,28-29,31H2,1-2H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341023
PNG
(1-(5-Chloro-4-fluoro-2-{[(3S)-3-[(4-methylpiperazi...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(F)c(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)CC1
Show InChI InChI=1S/C43H42ClFN6O3/c1-28-20-32(42(53)51(33-8-11-36(52)12-9-33)34-10-13-40-30(22-34)14-15-47(40)3)26-49(28)41-24-38(44)39(45)23-37(41)43(54)50-25-31-7-5-4-6-29(31)21-35(50)27-48-18-16-46(2)17-19-48/h4-15,20,22-24,26,35,52H,16-19,21,25,27H2,1-3H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341000
PNG
(N-(3,4-Difluorophenyl)-N-(4-hydroxyphenyl)-1-(6-{[...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(F)c(F)c3)c3ccccc23)CC1
Show InChI InChI=1S/C44H39F2N5O5/c1-47-16-18-48(19-17-47)25-32-20-28-6-2-3-7-29(28)24-49(32)43(53)35-22-41-42(56-27-55-41)23-40(35)50-26-36(34-8-4-5-9-39(34)50)44(54)51(30-10-13-33(52)14-11-30)31-12-15-37(45)38(46)21-31/h2-15,21-23,26,32,52H,16-20,24-25,27H2,1H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341010
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C40H39Cl2N5O3/c1-27-21-30(39(49)47(33-10-7-31(41)8-11-33)34-12-14-36(48)15-13-34)25-45(27)38-23-32(42)9-16-37(38)40(50)46-24-29-6-4-3-5-28(29)22-35(46)26-44-19-17-43(2)18-20-44/h3-16,21,23,25,35,48H,17-20,22,24,26H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341038
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(C)cc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C41H42ClN5O3/c1-28-8-11-34(12-9-28)47(35-13-15-37(48)16-14-35)40(49)32-22-29(2)45(26-32)39-24-33(42)10-17-38(39)41(50)46-25-31-7-5-4-6-30(31)23-36(46)27-44-20-18-43(3)19-21-44/h4-17,22,24,26,36,48H,18-21,23,25,27H2,1-3H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340997
PNG
(N-(3-Fluoro-4-methylphenyl)-N-(4-hydroxyphenyl)-1-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(C)c(F)c3)c3ccccc23)CC1
Show InChI InChI=1S/C45H42FN5O5/c1-29-11-12-33(22-39(29)46)51(32-13-15-35(52)16-14-32)45(54)38-27-50(40-10-6-5-9-36(38)40)41-24-43-42(55-28-56-43)23-37(41)44(53)49-25-31-8-4-3-7-30(31)21-34(49)26-48-19-17-47(2)18-20-48/h3-16,22-24,27,34,52H,17-21,25-26,28H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341033
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3[nH]ccc3c2)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340976
PNG
(N-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-1-(6-{[(3S)...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(Cl)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H40ClN5O5/c1-46-18-20-47(21-19-46)26-34-22-29-6-2-3-7-30(29)25-48(34)43(52)37-23-41-42(55-28-54-41)24-40(37)49-27-38(36-8-4-5-9-39(36)49)44(53)50(32-12-10-31(45)11-13-32)33-14-16-35(51)17-15-33/h2-17,23-24,27,34,51H,18-22,25-26,28H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341122
PNG
(1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc(C)cc2)c2ccccc12
Show InChI InChI=1S/C45H45N5O4/c1-31-17-19-35(20-18-31)50(34-13-5-4-6-14-34)45(53)39-30-49(40-16-10-9-15-37(39)40)41-27-43(54-3)42(51)26-38(41)44(52)48-28-33-12-8-7-11-32(33)25-36(48)29-47-23-21-46(2)22-24-47/h4-20,26-27,30,36,51H,21-25,28-29H2,1-3H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.60n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341012
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40ClN5O4/c1-27-21-30(39(49)46(32-8-12-35(47)13-9-32)33-10-14-36(48)15-11-33)25-44(27)38-23-31(41)7-16-37(38)40(50)45-24-29-6-4-3-5-28(29)22-34(45)26-43-19-17-42(2)18-20-43/h3-16,21,23,25,34,47-48H,17-20,22,24,26H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341067
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-...)
Show SMILES Cc1cc(cn1-c1cc2OCCc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C44H43N5O5/c1-29-21-34(43(51)49(35-7-10-38(50)11-8-35)36-9-12-40-31(23-36)13-15-45(40)2)27-47(29)41-25-42-32(14-18-54-42)24-39(41)44(52)48-26-33-6-4-3-5-30(33)22-37(48)28-46-16-19-53-20-17-46/h3-13,15,21,23-25,27,37,50H,14,16-20,22,26,28H2,1-2H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341044
PNG
(N-(3-Fluoro-4-hydroxyphenyl)-N-(1-methyl-1H-indol-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)c(F)c3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C47H43FN6O5/c1-49-17-19-51(20-18-49)27-35-21-30-7-3-4-8-32(30)26-52(35)46(56)37-24-44-45(59-29-58-44)25-42(37)53-28-38(36-9-5-6-10-41(36)53)47(57)54(34-12-14-43(55)39(48)23-34)33-11-13-40-31(22-33)15-16-50(40)2/h3-16,22-25,28,35,55H,17-21,26-27,29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341108
PNG
(1-{4-Hydroxy-5-methoxy-2-[(3S)-3-(piperidin-1-ylme...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCCCC1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C44H42N4O5/c1-53-42-26-40(37(25-41(42)50)43(51)46-27-31-13-7-6-12-30(31)24-34(46)28-45-22-10-3-11-23-45)47-29-38(36-16-8-9-17-39(36)47)44(52)48(32-14-4-2-5-15-32)33-18-20-35(49)21-19-33/h2,4-9,12-21,25-26,29,34,49-50H,3,10-11,22-24,27-28H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341042
PNG
(1-(5-Chloro-2-{[(3S)-3-[(dimethylamino)methyl]-3,4...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C40H38ClN5O3/c1-26-19-30(39(48)46(32-10-13-35(47)14-11-32)33-12-16-37-28(21-33)17-18-43(37)4)24-44(26)38-22-31(41)9-15-36(38)40(49)45-23-29-8-6-5-7-27(29)20-34(45)25-42(2)3/h5-19,21-22,24,34,47H,20,23,25H2,1-4H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341011
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C40H39ClFN5O3/c1-27-21-30(39(49)47(33-10-8-32(42)9-11-33)34-12-14-36(48)15-13-34)25-45(27)38-23-31(41)7-16-37(38)40(50)46-24-29-6-4-3-5-28(29)22-35(46)26-44-19-17-43(2)18-20-44/h3-16,21,23,25,35,48H,17-20,22,24,26H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341123
PNG
(N-Butyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methy...)
Show SMILES CCCCN(C(=O)c1cn(-c2cc(OC)c(O)cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C42H47N5O4/c1-4-5-19-45(32-15-7-6-8-16-32)42(50)36-29-47(37-18-12-11-17-34(36)37)38-26-40(51-3)39(48)25-35(38)41(49)46-27-31-14-10-9-13-30(31)24-33(46)28-44-22-20-43(2)21-23-44/h6-18,25-26,29,33,48H,4-5,19-24,27-28H2,1-3H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340990
PNG
(N-(4-Hydroxyphenyl)-N-(1-methyl-1H-indol-5-yl)-1-(...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C47H44N6O5/c1-48-19-21-50(22-20-48)28-36-23-31-7-3-4-8-33(31)27-51(36)46(55)39-25-44-45(58-30-57-44)26-43(39)52-29-40(38-9-5-6-10-42(38)52)47(56)53(34-11-14-37(54)15-12-34)35-13-16-41-32(24-35)17-18-49(41)2/h3-18,24-26,29,36,54H,19-23,27-28,30H2,1-2H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341031
PNG
(N-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-5-methyl-1-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C41H40FN5O5/c1-27-19-30(40(49)47(32-9-7-31(42)8-10-32)33-11-13-35(48)14-12-33)24-45(27)37-22-39-38(51-26-52-39)21-36(37)41(50)46-23-29-6-4-3-5-28(29)20-34(46)25-44-17-15-43(2)16-18-44/h3-14,19,21-22,24,34,48H,15-18,20,23,25-26H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341027
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-cyclopentylpiperazin-1-y...)
Show SMILES Cc1cc(cn1-c1cc(Br)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(CC1)C1CCCC1)C(=O)N(c1ccc(O)cc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340989
PNG
(N-(1-Benzofuran-5-yl)-N-(4-hydroxyphenyl)-1-(6-{[(...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4occc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C46H41N5O6/c1-47-17-19-48(20-18-47)27-35-22-30-6-2-3-7-32(30)26-49(35)45(53)38-24-43-44(57-29-56-43)25-41(38)50-28-39(37-8-4-5-9-40(37)50)46(54)51(33-10-13-36(52)14-11-33)34-12-15-42-31(23-34)16-21-55-42/h2-16,21,23-25,28,35,52H,17-20,22,26-27,29H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340996
PNG
(N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylpipera...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(OC(F)(F)F)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C45H40F3N5O6/c1-49-18-20-50(21-19-49)26-33-22-29-6-2-3-7-30(29)25-51(33)43(55)37-23-41-42(58-28-57-41)24-40(37)52-27-38(36-8-4-5-9-39(36)52)44(56)53(31-10-14-34(54)15-11-31)32-12-16-35(17-13-32)59-45(46,47)48/h2-17,23-24,27,33,54H,18-22,25-26,28H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341113
PNG
(1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C44H43N5O4/c1-45-21-23-46(24-22-45)29-35-25-31-13-9-10-14-32(31)28-47(35)43(51)37-26-41(50)42(53-2)27-40(37)48-30-38(36-19-11-12-20-39(36)48)44(52)49(33-15-5-3-6-16-33)34-17-7-4-8-18-34/h3-20,26-27,30,35,50H,21-25,28-29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341048
PNG
(N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylpipera...)
Show SMILES CC(C)n1ccc2cc(ccc12)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)cc1
Show InChI InChI=1S/C49H48N6O5/c1-32(2)52-19-18-34-25-37(14-17-43(34)52)55(36-12-15-39(56)16-13-36)49(58)42-30-54(44-11-7-6-10-40(42)44)45-27-47-46(59-31-60-47)26-41(45)48(57)53-28-35-9-5-4-8-33(35)24-38(53)29-51-22-20-50(3)21-23-51/h4-19,25-27,30,32,38,56H,20-24,28-29,31H2,1-3H3/t38-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341021
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(F)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H39ClFN5O3/c1-46-20-22-47(23-21-46)27-35-24-29-6-2-3-7-30(29)26-48(35)42(52)38-19-10-31(44)25-41(38)49-28-39(37-8-4-5-9-40(37)49)43(53)50(33-13-11-32(45)12-14-33)34-15-17-36(51)18-16-34/h2-19,25,28,35,51H,20-24,26-27H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340988
PNG
(N-(1-Benzothiophen-5-yl)-N-(4-hydroxyphenyl)-1-(6-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4sccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C46H41N5O5S/c1-47-17-19-48(20-18-47)27-35-22-30-6-2-3-7-32(30)26-49(35)45(53)38-24-42-43(56-29-55-42)25-41(38)50-28-39(37-8-4-5-9-40(37)50)46(54)51(33-10-13-36(52)14-11-33)34-12-15-44-31(23-34)16-21-57-44/h2-16,21,23-25,28,35,52H,17-20,22,26-27,29H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340995
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C40H39BrFN5O3/c1-27-21-30(39(49)47(33-10-8-32(42)9-11-33)34-12-14-36(48)15-13-34)25-45(27)38-23-31(41)7-16-37(38)40(50)46-24-29-6-4-3-5-28(29)22-35(46)26-44-19-17-43(2)18-20-44/h3-16,21,23,25,35,48H,17-20,22,24,26H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341007
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C40H39BrClN5O3/c1-27-21-30(39(49)47(33-10-8-32(42)9-11-33)34-12-14-36(48)15-13-34)25-45(27)38-23-31(41)7-16-37(38)40(50)46-24-29-6-4-3-5-28(29)22-35(46)26-44-19-17-43(2)18-20-44/h3-16,21,23,25,35,48H,17-20,22,24,26H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340971
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40ClN5O3/c1-28-22-31(39(48)46(33-10-4-3-5-11-33)34-13-15-36(47)16-14-34)26-44(28)38-24-32(41)12-17-37(38)40(49)45-25-30-9-7-6-8-29(30)23-35(45)27-43-20-18-42(2)19-21-43/h3-17,22,24,26,35,47H,18-21,23,25,27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341066
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-...)
Show SMILES Cc1cc(cn1-c1cc2CCCc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C45H45N5O4/c1-30-22-36(44(52)50(37-10-13-40(51)14-11-37)38-12-15-42-34(24-38)16-17-46(42)2)28-48(30)43-26-33-9-5-8-32(33)25-41(43)45(53)49-27-35-7-4-3-6-31(35)23-39(49)29-47-18-20-54-21-19-47/h3-4,6-7,10-17,22,24-26,28,39,51H,5,8-9,18-21,23,27,29H2,1-2H3/t39-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.60n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341006
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40BrN5O4/c1-27-21-30(39(49)46(32-8-12-35(47)13-9-32)33-10-14-36(48)15-11-33)25-44(27)38-23-31(41)7-16-37(38)40(50)45-24-29-6-4-3-5-28(29)22-34(45)26-43-19-17-42(2)18-20-43/h3-16,21,23,25,34,47-48H,17-20,22,24,26H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340979
PNG
(N-(3-Fluoro-4-hydroxyphenyl)-1-(6-{[(3S)-3-[(4-met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)c(F)c3)c3ccccc23)CC1
Show InChI InChI=1S/C44H40FN5O5/c1-46-17-19-47(20-18-46)26-33-21-29-9-5-6-10-30(29)25-48(33)43(52)35-23-41-42(55-28-54-41)24-39(35)49-27-36(34-13-7-8-14-38(34)49)44(53)50(31-11-3-2-4-12-31)32-15-16-40(51)37(45)22-32/h2-16,22-24,27,33,51H,17-21,25-26,28H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340985
PNG
(N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylpipera...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(CCc3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C46H45N5O5/c1-47-21-23-48(24-22-47)29-36-25-33-11-5-6-12-34(33)28-50(36)45(53)39-26-43-44(56-31-55-43)27-42(39)51-30-40(38-13-7-8-14-41(38)51)46(54)49(35-15-17-37(52)18-16-35)20-19-32-9-3-2-4-10-32/h2-18,26-27,30,36,52H,19-25,28-29,31H2,1H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341097
PNG
(N-(4-Hydroxyphenyl)-1-{6-[(3S)-3-[(4-methylpiperaz...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H41N5O5/c1-45-19-21-46(22-20-45)27-34-23-30-9-5-6-10-31(30)26-47(34)43(51)37-24-41-42(54-29-53-41)25-40(37)48-28-38(36-13-7-8-14-39(36)48)44(52)49(32-11-3-2-4-12-32)33-15-17-35(50)18-16-33/h2-18,24-25,28,34,50H,19-23,26-27,29H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341041
PNG
(1-(6-{[(3S)-3-[(Dimethylamino)methyl]-3,4-dihydroi...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C41H39N5O5/c1-26-17-30(40(48)46(31-9-12-34(47)13-10-31)32-11-14-36-28(19-32)15-16-43(36)4)23-44(26)37-21-39-38(50-25-51-39)20-35(37)41(49)45-22-29-8-6-5-7-27(29)18-33(45)24-42(2)3/h5-17,19-21,23,33,47H,18,22,24-25H2,1-4H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 7.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340974
PNG
(1-(5-Chloro-4-fluoro-2-{[(3S)-3-[(4-methylpiperazi...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(F)c(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H39ClFN5O3/c1-27-20-30(39(49)47(31-10-4-3-5-11-31)32-12-14-34(48)15-13-32)25-45(27)38-23-36(41)37(42)22-35(38)40(50)46-24-29-9-7-6-8-28(29)21-33(46)26-44-18-16-43(2)17-19-44/h3-15,20,22-23,25,33,48H,16-19,21,24,26H2,1-2H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341058
PNG
(N-(2,3-Dihydro-1H-indol-5-yl)-N-(4-hydroxyphenyl)-...)
Show SMILES Cc1cc(cn1-c1cc2CCCc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccc(O)cc1)c1ccc2NCCc2c1
Show InChI InChI=1S/C44H45N5O4/c1-29-21-35(43(51)49(36-9-12-39(50)13-10-36)37-11-14-41-33(23-37)15-16-45-41)27-47(29)42-25-32-8-4-7-31(32)24-40(42)44(52)48-26-34-6-3-2-5-30(34)22-38(48)28-46-17-19-53-20-18-46/h2-3,5-6,9-14,21,23-25,27,38,45,50H,4,7-8,15-20,22,26,28H2,1H3/t38-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341017
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(F)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H39BrFN5O3/c1-46-20-22-47(23-21-46)27-35-24-29-6-2-3-7-30(29)26-48(35)42(52)38-19-10-31(44)25-41(38)49-28-39(37-8-4-5-9-40(37)49)43(53)50(33-13-11-32(45)12-14-33)34-15-17-36(51)18-16-34/h2-19,25,28,35,51H,20-24,26-27H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341115
PNG
(1-{4,5-Dihydroxy-2-[(3S)-3-[(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(O)c(O)cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H41N5O5/c1-44-19-21-45(22-20-44)27-33-23-29-9-5-6-10-30(29)26-46(33)42(52)36-24-40(50)41(51)25-39(36)47-28-37(35-13-7-8-14-38(35)47)43(53)48(31-11-3-2-4-12-31)32-15-17-34(49)18-16-32/h2-18,24-25,28,33,49-51H,19-23,26-27H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340991
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3[nH]ccc3c2)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341050
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-cyclobutylpiperazin-1-yl...)
Show SMILES Cc1cc(cn1-c1cc(Br)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(CC1)C1CCC1)C(=O)N(c1ccc(O)cc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341022
PNG
(1-(5-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(Cl)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H39Cl2N5O3/c1-46-20-22-47(23-21-46)27-35-24-29-6-2-3-7-30(29)26-48(35)42(52)38-19-12-32(45)25-41(38)49-28-39(37-8-4-5-9-40(37)49)43(53)50(33-13-10-31(44)11-14-33)34-15-17-36(51)18-16-34/h2-19,25,28,35,51H,20-24,26-27H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 8.70n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341015
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C46H43BrN6O3/c1-48-21-23-50(24-22-48)29-37-25-31-7-3-4-8-33(31)28-51(37)45(55)40-17-11-34(47)27-44(40)52-30-41(39-9-5-6-10-43(39)52)46(56)53(35-12-15-38(54)16-13-35)36-14-18-42-32(26-36)19-20-49(42)2/h3-20,26-27,30,37,54H,21-25,28-29H2,1-2H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340998
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(C)cc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C41H42BrN5O3/c1-28-8-11-34(12-9-28)47(35-13-15-37(48)16-14-35)40(49)32-22-29(2)45(26-32)39-24-33(42)10-17-38(39)41(50)46-25-31-7-5-4-6-30(31)23-36(46)27-44-20-18-43(3)19-21-44/h4-17,22,24,26,36,48H,18-21,23,25,27H2,1-3H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340992
PNG
(N-(2,3-Dihydro-1H-indol-5-yl)-N-(4-hydroxyphenyl)-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4NCCc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C46H44N6O5/c1-48-18-20-49(21-19-48)27-35-22-30-6-2-3-7-32(30)26-50(35)45(54)38-24-43-44(57-29-56-43)25-42(38)51-28-39(37-8-4-5-9-41(37)51)46(55)52(33-10-13-36(53)14-11-33)34-12-15-40-31(23-34)16-17-47-40/h2-15,23-25,28,35,47,53H,16-22,26-27,29H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 9.20n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341039
PNG
(1-(3,5-Dichloro-2-{[(3S)-3-[(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2c(Cl)cc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3[nH]ccc3c2)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 9.60n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341125
PNG
(6-Fluoro-N-(4-hydroxyphenyl)-1-{6-[(3S)-3-[(4-meth...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccc(F)cc23)CC1
Show InChI InChI=1S/C44H40FN5O5/c1-46-17-19-47(20-18-46)26-34-21-29-7-5-6-8-30(29)25-48(34)43(52)37-23-41-42(55-28-54-41)24-40(37)49-27-38(36-16-11-31(45)22-39(36)49)44(53)50(32-9-3-2-4-10-32)33-12-14-35(51)15-13-33/h2-16,22-24,27,34,51H,17-21,25-26,28H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 9.80n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341131
PNG
(N-Butyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methy...)
Show SMILES CCCCN(C(=O)c1cn(-c2cc(OC)c(O)cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)cc1
Show InChI InChI=1S/C42H47N5O5/c1-4-5-18-45(31-14-16-33(48)17-15-31)42(51)36-28-47(37-13-9-8-12-34(36)37)38-25-40(52-3)39(49)24-35(38)41(50)46-26-30-11-7-6-10-29(30)23-32(46)27-44-21-19-43(2)20-22-44/h6-17,24-25,28,32,48-49H,4-5,18-23,26-27H2,1-3H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341095
PNG
(1-{5-Chloro-2-[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H40ClN5O3/c1-45-21-23-46(24-22-45)28-35-25-30-9-5-6-10-31(30)27-47(35)42(51)38-20-15-32(44)26-41(38)48-29-39(37-13-7-8-14-40(37)48)43(52)49(33-11-3-2-4-12-33)34-16-18-36(50)19-17-34/h2-20,26,29,35,50H,21-25,27-28H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 10.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341076
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN)-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C38H33N5O4/c1-47-35-22-33(31(21-34(35)44)37(45)41-24-26-13-9-8-12-25(26)20-29(41)23-39)43-32-19-11-10-18-30(32)36(40-43)38(46)42(27-14-4-2-5-15-27)28-16-6-3-7-17-28/h2-19,21-22,29,44H,20,23-24,39H2,1H3/t29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 10.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340993
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4[nH]ccc4c3)c3ccccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 10.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340966
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40BrN5O3/c1-28-22-31(39(48)46(33-10-4-3-5-11-33)34-13-15-36(47)16-14-34)26-44(28)38-24-32(41)12-17-37(38)40(49)45-25-30-9-7-6-8-29(30)23-35(45)27-43-20-18-42(2)19-21-43/h3-17,22,24,26,35,47H,18-21,23,25,27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 10.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341112
PNG
(1-{6-[(3S)-3-[(Dimethylamino)methyl]-1,2,3,4-tetra...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C41H36N4O5/c1-42(2)24-31-20-27-10-6-7-11-28(27)23-43(31)40(47)34-21-38-39(50-26-49-38)22-37(34)44-25-35(33-14-8-9-15-36(33)44)41(48)45(29-12-4-3-5-13-29)30-16-18-32(46)19-17-30/h3-19,21-22,25,31,46H,20,23-24,26H2,1-2H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341100
PNG
(N-(4-Hydroxyphenyl)-1-{5-methoxy-2-[(3S)-3-[(4-met...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c(c1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C44H43N5O4/c1-45-22-24-46(25-23-45)29-35-26-31-10-6-7-11-32(31)28-47(35)43(51)39-21-20-37(53-2)27-42(39)48-30-40(38-14-8-9-15-41(38)48)44(52)49(33-12-4-3-5-13-33)34-16-18-36(50)19-17-34/h3-21,27,30,35,50H,22-26,28-29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 11.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340875
PNG
(1-(5-Hydroxy-2-{[(3S)-3-[(4-methylpiperazin-1-yl)m...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(O)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H41N5O4/c1-28-22-31(39(48)45(32-10-4-3-5-11-32)33-12-14-35(46)15-13-33)26-43(28)38-24-36(47)16-17-37(38)40(49)44-25-30-9-7-6-8-29(30)23-34(44)27-42-20-18-41(2)19-21-42/h3-17,22,24,26,34,46-47H,18-21,23,25,27H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 11.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341092
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C38H31ClN4O3/c39-27-14-19-33(37(45)41-23-26-9-5-4-8-25(26)20-30(41)22-40)36(21-27)42-24-34(32-12-6-7-13-35(32)42)38(46)43(28-10-2-1-3-11-28)29-15-17-31(44)18-16-29/h1-19,21,24,30,44H,20,22-23,40H2/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 11.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341059
PNG
(N-(4-Hydroxyphenyl)-5-methyl-1-(6-{[(3R)-3-methyl-...)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1cccc(c1)N1CCN(C)CC1
Show InChI InChI=1S/C41H41N5O5/c1-27-20-31(40(48)46(32-11-13-35(47)14-12-32)34-10-6-9-33(21-34)43-17-15-42(3)16-18-43)25-44(27)37-23-39-38(50-26-51-39)22-36(37)41(49)45-24-30-8-5-4-7-29(30)19-28(45)2/h4-14,20-23,25,28,47H,15-19,24,26H2,1-3H3/t28-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 11.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341065
PNG
(N-(4-Hydroxyphenyl)-5-methyl-1-(6-{[(3R)-3-methyl-...)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2n(CCN3CCOCC3)ccc2c1
Show InChI InChI=1S/C44H43N5O6/c1-29-22-34(27-47(29)40-25-42-41(54-28-55-42)24-38(40)44(52)48-26-33-6-4-3-5-31(33)21-30(48)2)43(51)49(35-7-10-37(50)11-8-35)36-9-12-39-32(23-36)13-14-46(39)16-15-45-17-19-53-20-18-45/h3-14,22-25,27,30,50H,15-21,26,28H2,1-2H3/t30-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 12.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341083
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C39H34N4O5/c1-48-37-21-35(32(20-36(37)45)38(46)41-23-26-10-6-5-9-25(26)19-29(41)22-40)42-24-33(31-13-7-8-14-34(31)42)39(47)43(27-11-3-2-4-12-27)28-15-17-30(44)18-16-28/h2-18,20-21,24,29,44-45H,19,22-23,40H2,1H3/t29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 12.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340984
PNG
(N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylpipera...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3cccc(Oc4ccccc4)c3)c3ccccc23)CC1
Show InChI InChI=1S/C50H45N5O6/c1-51-22-24-52(25-23-51)31-38-26-34-10-5-6-11-35(34)30-53(38)49(57)43-28-47-48(60-33-59-47)29-46(43)54-32-44(42-16-7-8-17-45(42)54)50(58)55(36-18-20-39(56)21-19-36)37-12-9-15-41(27-37)61-40-13-3-2-4-14-40/h2-21,27-29,32,38,56H,22-26,30-31,33H2,1H3/t38-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 12.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340994
PNG
(N-(4-Hydroxyphenyl)-N-(4-methoxyphenyl)-1-(6-{[(3S...)
Show SMILES COc1ccc(cc1)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)cc1
Show InChI InChI=1S/C45H43N5O6/c1-46-19-21-47(22-20-46)27-34-23-30-7-3-4-8-31(30)26-48(34)44(52)38-24-42-43(56-29-55-42)25-41(38)49-28-39(37-9-5-6-10-40(37)49)45(53)50(32-11-15-35(51)16-12-32)33-13-17-36(54-2)18-14-33/h3-18,24-25,28,34,51H,19-23,26-27,29H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 13.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341091
PNG
(N-(4-Hydroxyphenyl)-1-{2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccccc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H41N5O3/c1-44-23-25-45(26-24-44)29-35-27-31-11-5-6-12-32(31)28-46(35)42(50)38-16-8-10-18-41(38)47-30-39(37-15-7-9-17-40(37)47)43(51)48(33-13-3-2-4-14-33)34-19-21-36(49)22-20-34/h2-22,30,35,49H,23-29H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 13.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341001
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H42BrN5O3/c1-30-11-14-34(15-12-30)50(35-16-18-37(51)19-17-35)44(53)40-29-49(41-10-6-5-9-38(40)41)42-26-33(45)13-20-39(42)43(52)48-27-32-8-4-3-7-31(32)25-36(48)28-47-23-21-46(2)22-24-47/h3-20,26,29,36,51H,21-25,27-28H2,1-2H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 13.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341121
PNG
(N-(4-Fluorophenyl)-1-{4-hydroxy-5-methoxy-2-[(3S)-...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc(F)cc2)c2ccccc12
Show InChI InChI=1S/C44H42FN5O4/c1-46-20-22-47(23-21-46)28-35-24-30-10-6-7-11-31(30)27-48(35)43(52)37-25-41(51)42(54-2)26-40(37)49-29-38(36-14-8-9-15-39(36)49)44(53)50(33-12-4-3-5-13-33)34-18-16-32(45)17-19-34/h3-19,25-26,29,35,51H,20-24,27-28H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 13.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341053
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-...)
Show SMILES Cc1cc(cn1-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCCC1)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C43H41N5O5/c1-28-19-32(42(50)48(33-9-12-36(49)13-10-33)34-11-14-38-30(21-34)15-18-44(38)2)25-46(28)39-23-41-40(52-27-53-41)22-37(39)43(51)47-24-31-8-4-3-7-29(31)20-35(47)26-45-16-5-6-17-45/h3-4,7-15,18-19,21-23,25,35,49H,5-6,16-17,20,24,26-27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 13.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341116
PNG
(N-(4-Hydroxyphenyl)-1-{6-[(3S)-3-(morpholin-4-ylme...)
Show SMILES Oc1ccc(cc1)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C43H38N4O6/c48-34-16-14-32(15-17-34)47(31-10-2-1-3-11-31)43(50)37-27-46(38-13-7-6-12-35(37)38)39-24-41-40(52-28-53-41)23-36(39)42(49)45-25-30-9-5-4-8-29(30)22-33(45)26-44-18-20-51-21-19-44/h1-17,23-24,27,33,48H,18-22,25-26,28H2/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 14.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341063
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-2,3-dihyd...)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2N(C)CCc2c1
Show InChI InChI=1S/C39H36N4O5/c1-24-17-29(38(45)43(30-8-11-32(44)12-9-30)31-10-13-34-27(18-31)14-15-40(34)3)22-41(24)35-20-37-36(47-23-48-37)19-33(35)39(46)42-21-28-7-5-4-6-26(28)16-25(42)2/h4-13,17-20,22,25,44H,14-16,21,23H2,1-3H3/t25-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 14.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340968
PNG
(N-(4-Hydroxyphenyl)-5-methyl-1-(6-{[(3S)-3-[(4-met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C41H41N5O5/c1-28-20-31(40(48)46(32-10-4-3-5-11-32)33-12-14-35(47)15-13-33)25-44(28)37-23-39-38(50-27-51-39)22-36(37)41(49)45-24-30-9-7-6-8-29(30)21-34(45)26-43-18-16-42(2)17-19-43/h3-15,20,22-23,25,34,47H,16-19,21,24,26-27H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 15.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341093
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc(NC(=O)CSc2ccccc2)ccc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C46H39N5O4S/c47-27-36-25-31-11-7-8-12-32(31)28-49(36)45(54)40-26-33(48-44(53)30-56-38-15-5-2-6-16-38)19-24-43(40)50-29-41(39-17-9-10-18-42(39)50)46(55)51(34-13-3-1-4-14-34)35-20-22-37(52)23-21-35/h1-24,26,29,36,52H,25,27-28,30,47H2,(H,48,53)/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 16.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340860
PNG
(1-(5-Chloro-2-{[(3S)-3-[(dimethylamino)methyl]-3,4...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-n1cc(cc1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C37H35ClN4O3/c1-25-19-28(36(44)42(30-11-5-4-6-12-30)31-14-16-33(43)17-15-31)23-40(25)35-21-29(38)13-18-34(35)37(45)41-22-27-10-8-7-9-26(27)20-32(41)24-39(2)3/h4-19,21,23,32,43H,20,22,24H2,1-3H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 16.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341120
PNG
(1-[(2S)-2-[(Benzyloxy)methyl]-7-[(3S)-3-[(4-methyl...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3O[C@@H](COCc4ccccc4)COc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C53H51N5O6/c1-54-24-26-55(27-25-54)32-42-28-38-14-8-9-15-39(38)31-56(42)52(60)46-29-51-50(63-36-44(64-51)35-62-34-37-12-4-2-5-13-37)30-49(46)57-33-47(45-18-10-11-19-48(45)57)53(61)58(40-16-6-3-7-17-40)41-20-22-43(59)23-21-41/h2-23,29-30,33,42,44,59H,24-28,31-32,34-36H2,1H3/t42-,44-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 16.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341102
PNG
(N-(4-Hydroxyphenyl)-1-{7-[(3S)-3-[(4-methylpiperaz...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C45H43N5O5/c1-46-19-21-47(22-20-46)29-35-25-31-9-5-6-10-32(31)28-48(35)44(52)38-26-42-43(55-24-23-54-42)27-41(38)49-30-39(37-13-7-8-14-40(37)49)45(53)50(33-11-3-2-4-12-33)34-15-17-36(51)18-16-34/h2-18,26-27,30,35,51H,19-25,28-29H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 16.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341084
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN)c(c1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C39H34N4O4/c1-47-32-19-20-34(38(45)41-24-27-10-6-5-9-26(27)21-30(41)23-40)37(22-32)42-25-35(33-13-7-8-14-36(33)42)39(46)43(28-11-3-2-4-12-28)29-15-17-31(44)18-16-29/h2-20,22,25,30,44H,21,23-24,40H2,1H3/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 17.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341117
PNG
(1-{2-Ethyl-7-[(3S)-3-[(4-methylpiperazin-1-yl)meth...)
Show SMILES CCC1COc2cc(c(cc2O1)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C47H47N5O5/c1-3-38-31-56-44-27-43(40(26-45(44)57-38)46(54)50-28-33-12-8-7-11-32(33)25-36(50)29-49-23-21-48(2)22-24-49)51-30-41(39-15-9-10-16-42(39)51)47(55)52(34-13-5-4-6-14-34)35-17-19-37(53)20-18-35/h4-20,26-27,30,36,38,53H,3,21-25,28-29,31H2,1-2H3/t36-,38?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 17.3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341051
PNG
(N-(2,3-Dihydro-1H-indol-5-yl)-N-(4-hydroxyphenyl)-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3NCCc3c2)CC1
Show InChI InChI=1S/C43H44N6O5/c1-28-19-32(42(51)49(33-7-10-36(50)11-8-33)34-9-12-38-30(21-34)13-14-44-38)25-47(28)39-23-41-40(53-27-54-41)22-37(39)43(52)48-24-31-6-4-3-5-29(31)20-35(48)26-46-17-15-45(2)16-18-46/h3-12,19,21-23,25,35,44,50H,13-18,20,24,26-27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 17.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341110
PNG
(1-{5-Chloro-2-[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(C(=O)N(c3ccccc3)c3ccccc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H40ClN5O2/c1-45-22-24-46(25-23-45)29-36-26-31-12-8-9-13-32(31)28-47(36)42(50)38-21-20-33(44)27-41(38)48-30-39(37-18-10-11-19-40(37)48)43(51)49(34-14-4-2-5-15-34)35-16-6-3-7-17-35/h2-21,27,30,36H,22-26,28-29H2,1H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 17.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341029
PNG
(N-(3-Chloro-4-hydroxyphenyl)-N-(1H-indol-5-yl)-1-(...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)c(Cl)c3)c3ccc4[nH]ccc4c3)c3ccccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 17.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341111
PNG
(1-{5-Chloro-2-[(3S)-3-[(dimethylamino)methyl]-1,2,...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C40H35ClN4O3/c1-42(2)25-32-22-27-10-6-7-11-28(27)24-43(32)39(47)35-21-16-29(41)23-38(35)44-26-36(34-14-8-9-15-37(34)44)40(48)45(30-12-4-3-5-13-30)31-17-19-33(46)20-18-31/h3-21,23,26,32,46H,22,24-25H2,1-2H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 18.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341052
PNG
(1-(5-Bromo-2-{[(3S)-3-(pyrrolidin-1-ylmethyl)-3,4-...)
Show SMILES Cc1cc(cn1-c1cc(Br)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCCC1)C(=O)N(c1ccc(O)cc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 18.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341109
PNG
(1-{6-[(3S)-3-[(4-Methylpiperazin-1-yl)methyl]-1,2,...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccccc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H41N5O4/c1-45-20-22-46(23-21-45)28-35-24-31-12-8-9-13-32(31)27-47(35)43(50)37-25-41-42(53-30-52-41)26-40(37)48-29-38(36-18-10-11-19-39(36)48)44(51)49(33-14-4-2-5-15-33)34-16-6-3-7-17-34/h2-19,25-26,29,35H,20-24,27-28,30H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 18.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341134
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C38H32N4O3/c39-23-30-22-26-10-4-5-11-27(26)24-40(30)37(44)33-15-7-9-17-36(33)41-25-34(32-14-6-8-16-35(32)41)38(45)42(28-12-2-1-3-13-28)29-18-20-31(43)21-19-29/h1-21,25,30,43H,22-24,39H2/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 18.9n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341003
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(Cl)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C43H39BrClN5O3/c1-46-20-22-47(23-21-46)27-35-24-29-6-2-3-7-30(29)26-48(35)42(52)38-19-10-31(44)25-41(38)49-28-39(37-8-4-5-9-40(37)49)43(53)50(33-13-11-32(45)12-14-33)34-15-17-36(51)18-16-34/h2-19,25,28,35,51H,20-24,26-27H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 19.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341060
PNG
(N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-(morpholin-4-ylm...)
Show SMILES Oc1ccc(cc1)N(C(=O)c1cn(c2CCCCc12)-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)c1ccccc1
Show InChI InChI=1S/C43H42N4O6/c48-34-16-14-32(15-17-34)47(31-10-2-1-3-11-31)43(50)37-27-46(38-13-7-6-12-35(37)38)39-24-41-40(52-28-53-41)23-36(39)42(49)45-25-30-9-5-4-8-29(30)22-33(45)26-44-18-20-51-21-19-44/h1-5,8-11,14-17,23-24,27,33,48H,6-7,12-13,18-22,25-26,28H2/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 19.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341035
PNG
(5-Chloro-N-(4-hydroxyphenyl)-N-(1H-indol-5-yl)-1-(...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4[nH]ccc4c3)c3cc(Cl)ccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 19.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341054
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(4-methylphenyl)-1-...)
Show SMILES Cc1cc(cn1-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccc(C)cc1)c1ccc(O)cc1
Show InChI InChI=1S/C41H40N4O6/c1-27-7-9-32(10-8-27)45(33-11-13-35(46)14-12-33)40(47)31-19-28(2)43(24-31)37-22-39-38(50-26-51-39)21-36(37)41(48)44-23-30-6-4-3-5-29(30)20-34(44)25-42-15-17-49-18-16-42/h3-14,19,21-22,24,34,46H,15-18,20,23,25-26H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 19.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340972
PNG
(N-(3-Chloro-4-hydroxyphenyl)-1-(5-chloro-2-{[(3S)-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)c(Cl)c2)CC1
Show InChI InChI=1S/C40H39Cl2N5O3/c1-27-20-30(39(49)47(32-10-4-3-5-11-32)33-13-15-38(48)36(42)23-33)25-45(27)37-22-31(41)12-14-35(37)40(50)46-24-29-9-7-6-8-28(29)21-34(46)26-44-18-16-43(2)17-19-44/h3-15,20,22-23,25,34,48H,16-19,21,24,26H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 20.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341002
PNG
(N-(3-Chloro-4-fluorophenyl)-N-(4-hydroxyphenyl)-1-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(F)c(Cl)c3)c3ccccc23)CC1
Show InChI InChI=1S/C44H39ClFN5O5/c1-47-16-18-48(19-17-47)25-32-20-28-6-2-3-7-29(28)24-49(32)43(53)35-22-41-42(56-27-55-41)23-40(35)50-26-36(34-8-4-5-9-39(34)50)44(54)51(30-10-13-33(52)14-11-30)31-12-15-38(46)37(45)21-31/h2-15,21-23,26,32,52H,16-20,24-25,27H2,1H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 20.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341119
PNG
(N-Cyclohexyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(C2CCCCC2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C44H49N5O4/c1-45-21-23-46(24-22-45)29-35-25-31-13-9-10-14-32(31)28-47(35)43(51)37-26-41(50)42(53-2)27-40(37)48-30-38(36-19-11-12-20-39(36)48)44(52)49(33-15-5-3-6-16-33)34-17-7-4-8-18-34/h3,5-6,9-16,19-20,26-27,30,34-35,50H,4,7-8,17-18,21-25,28-29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 21.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341087
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc(NC(=O)CSc2ccccc2)ccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C45H38N6O3S/c46-28-36-26-31-14-10-11-15-32(31)29-49(36)44(53)39-27-33(47-42(52)30-55-37-20-8-3-9-21-37)24-25-41(39)51-40-23-13-12-22-38(40)43(48-51)45(54)50(34-16-4-1-5-17-34)35-18-6-2-7-19-35/h1-25,27,36H,26,28-30,46H2,(H,47,52)/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 21.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340870
PNG
(1-(5-Hydroxy-2-{[(3S)-3-(morpholin-4-ylmethyl)-3,4...)
Show SMILES Cc1cc(cn1-c1cc(O)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C39H38N4O5/c1-27-21-30(38(46)43(31-9-3-2-4-10-31)32-11-13-34(44)14-12-32)25-41(27)37-23-35(45)15-16-36(37)39(47)42-24-29-8-6-5-7-28(29)22-33(42)26-40-17-19-48-20-18-40/h2-16,21,23,25,33,44-45H,17-20,22,24,26H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 22.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341085
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN)c(c1)-n1cc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C39H34N4O3/c1-46-32-20-21-34(38(44)41-25-28-13-9-8-12-27(28)22-31(41)24-40)37(23-32)42-26-35(33-18-10-11-19-36(33)42)39(45)43(29-14-4-2-5-15-29)30-16-6-3-7-17-30/h2-21,23,26,31H,22,24-25,40H2,1H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 22.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341096
PNG
(N-(4-Hydroxyphenyl)-1-{2-[(3S)-3-[(4-methylpiperaz...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(NC(=O)CSc3ccccc3)ccc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C51H48N6O4S/c1-53-26-28-54(29-27-53)33-41-30-36-12-8-9-13-37(36)32-55(41)50(60)45-31-38(52-49(59)35-62-43-16-6-3-7-17-43)20-25-48(45)56-34-46(44-18-10-11-19-47(44)56)51(61)57(39-14-4-2-5-15-39)40-21-23-42(58)24-22-40/h2-25,31,34,41,58H,26-30,32-33,35H2,1H3,(H,52,59)/t41-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 22.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340987
PNG
(1-(5-Bromo-2-{[(3S)-3-(morpholin-4-ylmethyl)-3,4-d...)
Show SMILES Cc1cc(cn1-c1cc(Br)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C39H37BrN4O4/c1-27-21-30(38(46)44(32-9-3-2-4-10-32)33-12-14-35(45)15-13-33)25-42(27)37-23-31(40)11-16-36(37)39(47)43-24-29-8-6-5-7-28(29)22-34(43)26-41-17-19-48-20-18-41/h2-16,21,23,25,34,45H,17-20,22,24,26H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 23.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341118
PNG
(1-{5-Chloro-2-[(3S)-3-(morpholin-4-ylmethyl)-1,2,3...)
Show SMILES Oc1ccc(cc1)N(C(=O)c1cn(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C42H37ClN4O4/c43-31-14-19-37(41(49)45-26-30-9-5-4-8-29(30)24-34(45)27-44-20-22-51-23-21-44)40(25-31)46-28-38(36-12-6-7-13-39(36)46)42(50)47(32-10-2-1-3-11-32)33-15-17-35(48)18-16-33/h1-19,25,28,34,48H,20-24,26-27H2/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 23.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341061
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(2-methyl-2,3-dihyd...)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2CN(C)Cc2c1
Show InChI InChI=1S/C39H36N4O5/c1-24-15-30(38(45)43(31-10-12-33(44)13-11-31)32-9-8-28-19-40(3)20-29(28)16-32)22-41(24)35-18-37-36(47-23-48-37)17-34(35)39(46)42-21-27-7-5-4-6-26(27)14-25(42)2/h4-13,15-18,22,25,44H,14,19-21,23H2,1-3H3/t25-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 23.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340965
PNG
(1-(5-fluoro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(F)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40FN5O3/c1-28-22-31(39(48)46(33-10-4-3-5-11-33)34-13-15-36(47)16-14-34)26-44(28)38-24-32(41)12-17-37(38)40(49)45-25-30-9-7-6-8-29(30)23-35(45)27-43-20-18-42(2)19-21-43/h3-17,22,24,26,35,47H,18-21,23,25,27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 24.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340866
PNG
(1-(2-{[(3S)-3-[(Dimethylamino)methyl]-3,4-dihydroi...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(F)cc1-n1cc(cc1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C37H35FN4O3/c1-25-19-28(36(44)42(30-11-5-4-6-12-30)31-14-16-33(43)17-15-31)23-40(25)35-21-29(38)13-18-34(35)37(45)41-22-27-10-8-7-9-26(27)20-32(41)24-39(2)3/h4-19,21,23,32,43H,20,22,24H2,1-3H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 24.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341078
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES CNc1ccc(c(c1)C(=O)N1Cc2ccccc2C[C@H]1CN)-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C38H34N6O2/c1-40-28-20-21-35(33(23-28)37(45)42-25-27-13-9-8-12-26(27)22-31(42)24-39)44-34-19-11-10-18-32(34)36(41-44)38(46)43(29-14-4-2-5-15-29)30-16-6-3-7-17-30/h2-21,23,31,40H,22,24-25,39H2,1H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341107
PNG
(1-{2-[(3S)-3-[(Dimethylamino)methyl]-1,2,3,4-tetra...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN(C)C)c(c1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C41H38N4O4/c1-42(2)26-32-23-28-11-7-8-12-29(28)25-43(32)40(47)36-22-21-34(49-3)24-39(36)44-27-37(35-15-9-10-16-38(35)44)41(48)45(30-13-5-4-6-14-30)31-17-19-33(46)20-18-31/h4-22,24,27,32,46H,23,25-26H2,1-3H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 25.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340967
PNG
(1-(2-{[(3S)-3-[(Dimethylamino)methyl]-3,4-dihydroi...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 26.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341086
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C37H31N5O3/c38-23-29-22-25-10-4-5-11-26(25)24-40(29)36(44)32-15-7-9-17-34(32)42-33-16-8-6-14-31(33)35(39-42)37(45)41(27-12-2-1-3-13-27)28-18-20-30(43)21-19-28/h1-21,29,43H,22-24,38H2/t29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 28.3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341068
PNG
(N-(4-Hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-...)
Show SMILES Cc1cc(cn1-c1cc2occc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C44H41N5O5/c1-29-21-34(43(51)49(35-7-10-38(50)11-8-35)36-9-12-40-31(23-36)13-15-45(40)2)27-47(29)41-25-42-32(14-18-54-42)24-39(41)44(52)48-26-33-6-4-3-5-30(33)22-37(48)28-46-16-19-53-20-17-46/h3-15,18,21,23-25,27,37,50H,16-17,19-20,22,26,28H2,1-2H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 28.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340872
PNG
(1-(4,5-Dibromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(Br)c(Br)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H39Br2N5O3/c1-27-20-30(39(49)47(31-10-4-3-5-11-31)32-12-14-34(48)15-13-32)25-45(27)38-23-37(42)36(41)22-35(38)40(50)46-24-29-9-7-6-8-28(29)21-33(46)26-44-18-16-43(2)17-19-44/h3-15,20,22-23,25,33,48H,16-19,21,24,26H2,1-2H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 29.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341124
PNG
(5-Fluoro-N-(4-hydroxyphenyl)-1-{6-[(3S)-3-[(4-meth...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3cc(F)ccc23)CC1
Show InChI InChI=1S/C44H40FN5O5/c1-46-17-19-47(20-18-46)26-34-21-29-7-5-6-8-30(29)25-48(34)43(52)37-23-41-42(55-28-54-41)24-40(37)49-27-38(36-22-31(45)11-16-39(36)49)44(53)50(32-9-3-2-4-10-32)33-12-14-35(51)15-13-33/h2-16,22-24,27,34,51H,17-21,25-26,28H2,1H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 31.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341073
PNG
(1-{6-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C38H31N5O4/c39-22-29-19-25-11-7-8-12-26(25)23-41(29)37(44)31-20-34-35(47-24-46-34)21-33(31)43-32-18-10-9-17-30(32)36(40-43)38(45)42(27-13-3-1-4-14-27)28-15-5-2-6-16-28/h1-18,20-21,29H,19,22-24,39H2/t29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 31.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341082
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc(NC(=O)COc2ccccc2)ccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C45H38N6O4/c46-28-36-26-31-14-10-11-15-32(31)29-49(36)44(53)39-27-33(47-42(52)30-55-37-20-8-3-9-21-37)24-25-41(39)51-40-23-13-12-22-38(40)43(48-51)45(54)50(34-16-4-1-5-17-34)35-18-6-2-7-19-35/h1-25,27,36H,26,28-30,46H2,(H,47,52)/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341056
PNG
(N-(4-Hydroxyphenyl)-5-methyl-1-(6-{[(3S)-3-(morpho...)
Show SMILES Cc1cc(cn1-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C40H38N4O6/c1-27-19-30(39(46)44(31-9-3-2-4-10-31)32-11-13-34(45)14-12-32)24-42(27)36-22-38-37(49-26-50-38)21-35(36)40(47)43-23-29-8-6-5-7-28(29)20-33(43)25-41-15-17-48-18-16-41/h2-14,19,21-22,24,33,45H,15-18,20,23,25-26H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 35.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341099
PNG
(1-{5-Chloro-4-methoxy-2-[(3S)-3-[(4-methylpiperazi...)
Show SMILES COc1cc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c(cc1Cl)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C44H42ClN5O4/c1-46-20-22-47(23-21-46)28-34-24-30-10-6-7-11-31(30)27-48(34)43(52)37-25-42(54-2)39(45)26-41(37)49-29-38(36-14-8-9-15-40(36)49)44(53)50(32-12-4-3-5-13-32)33-16-18-35(51)19-17-33/h3-19,25-26,29,34,51H,20-24,27-28H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 37.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341106
PNG
(N-(4-Hydroxyphenyl)-N-phenyl-1-{6-[(3S)-3-(piperid...)
Show SMILES Oc1ccc(cc1)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCCCC2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C44H40N4O5/c49-35-19-17-33(18-20-35)48(32-13-3-1-4-14-32)44(51)38-28-47(39-16-8-7-15-36(38)39)40-25-42-41(52-29-53-42)24-37(40)43(50)46-26-31-12-6-5-11-30(31)23-34(46)27-45-21-9-2-10-22-45/h1,3-8,11-20,24-25,28,34,49H,2,9-10,21-23,26-27,29H2/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 41.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341055
PNG
(N-(4-Hydroxyphenyl)-5-methyl-1-(6-{[(3S)-3-(morpho...)
Show SMILES Cc1cc(cn1-c1cc2CCCc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C42H42N4O4/c1-29-22-34(41(48)46(35-12-3-2-4-13-35)36-14-16-38(47)17-15-36)27-44(29)40-25-32-11-7-10-31(32)24-39(40)42(49)45-26-33-9-6-5-8-30(33)23-37(45)28-43-18-20-50-21-19-43/h2-6,8-9,12-17,22,24-25,27,37,47H,7,10-11,18-21,23,26,28H2,1H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340975
PNG
(1-(4-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(Br)ccc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40BrN5O3/c1-28-22-31(39(48)46(33-10-4-3-5-11-33)34-13-15-36(47)16-14-34)26-44(28)38-17-12-32(41)24-37(38)40(49)45-25-30-9-7-6-8-29(30)23-35(45)27-43-20-18-42(2)19-21-43/h3-17,22,24,26,35,47H,18-21,23,25,27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 44.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340878
PNG
(1-(3-Chloro-2-{[(3S)-3-[(dimethylamino)methyl]-3,4...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1c(Cl)cccc1-n1cc(cc1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C37H35ClN4O3/c1-25-20-28(36(44)42(29-12-5-4-6-13-29)30-16-18-32(43)19-17-30)23-40(25)34-15-9-14-33(38)35(34)37(45)41-22-27-11-8-7-10-26(27)21-31(41)24-39(2)3/h4-20,23,31,43H,21-22,24H2,1-3H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 44.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340854
PNG
(1-(2-{[(3S)-3-(Aminomethyl)-3,4-dihydroisoquinolin...)
Show SMILES Cc1cc(cn1-c1cc(O)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN)C(=O)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H32N4O3/c1-24-18-27(34(41)39(28-12-4-2-5-13-28)29-14-6-3-7-15-29)23-37(24)33-20-31(40)16-17-32(33)35(42)38-22-26-11-9-8-10-25(26)19-30(38)21-36/h2-18,20,23,30,40H,19,21-22,36H2,1H3/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 50.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341088
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN)c(c1)-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C38H33N5O3/c1-46-31-20-21-33(37(44)41-25-27-13-9-8-12-26(27)22-30(41)24-39)35(23-31)43-34-19-11-10-18-32(34)36(40-43)38(45)42(28-14-4-2-5-15-28)29-16-6-3-7-17-29/h2-21,23,30H,22,24-25,39H2,1H3/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341077
PNG
(1-{4-Amino-2-[(3S)-3-(aminomethyl)-1,2,3,4-tetrahy...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc(N)ccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C37H32N6O2/c38-23-30-21-25-11-7-8-12-26(25)24-41(30)36(44)32-22-27(39)19-20-34(32)43-33-18-10-9-17-31(33)35(40-43)37(45)42(28-13-3-1-4-14-28)29-15-5-2-6-16-29/h1-20,22,30H,21,23-24,38-39H2/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 52.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341070
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C37H31N5O2/c38-24-30-23-26-13-7-8-14-27(26)25-40(30)36(43)32-20-10-12-22-34(32)42-33-21-11-9-19-31(33)35(39-42)37(44)41(28-15-3-1-4-16-28)29-17-5-2-6-18-29/h1-22,30H,23-25,38H2/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 53.3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341094
PNG
(1-{6-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES CC(C)CC1Oc2cc(C(=O)N3Cc4ccccc4C[C@H]3CN)c(cc2O1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C43H40N4O5/c1-27(2)20-41-51-39-22-35(42(49)45-25-29-11-7-6-10-28(29)21-32(45)24-44)38(23-40(39)52-41)46-26-36(34-14-8-9-15-37(34)46)43(50)47(30-12-4-3-5-13-30)31-16-18-33(48)19-17-31/h3-19,22-23,26-27,32,41,48H,20-21,24-25,44H2,1-2H3/t32-,41?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 54.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341079
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES CN(C)c1ccc(c(c1)C(=O)N1Cc2ccccc2C[C@H]1CN)-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C39H36N6O2/c1-42(2)31-21-22-36(34(24-31)38(46)43-26-28-14-10-9-13-27(28)23-32(43)25-40)45-35-20-12-11-19-33(35)37(41-45)39(47)44(29-15-5-3-6-16-29)30-17-7-4-8-18-30/h3-22,24,32H,23,25-26,40H2,1-2H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 56.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340999
PNG
(N-(1H-Indol-5-yl)-N-(4-methylphenyl)-1-(6-{[(3S)-3...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc4[nH]ccc4c3)c3ccccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 57.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341127
PNG
(N,N-Dibutyl-1-{2-[(3S)-3-[(4-methylpiperazin-1-yl)...)
Show SMILES CCCCN(CCCC)C(=O)c1cn(-c2ccc(NC(=O)CSc3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C47H56N6O3S/c1-4-6-23-51(24-7-5-2)46(55)42-33-53(43-20-14-13-19-40(42)43)44-22-21-37(48-45(54)34-57-39-17-9-8-10-18-39)30-41(44)47(56)52-31-36-16-12-11-15-35(36)29-38(52)32-50-27-25-49(3)26-28-50/h8-22,30,33,38H,4-7,23-29,31-32,34H2,1-3H3,(H,48,54)/t38-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 57.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341080
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc(NCc2ccccc2)ccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C44H38N6O2/c45-28-37-26-32-16-10-11-17-33(32)30-48(37)43(51)39-27-34(46-29-31-14-4-1-5-15-31)24-25-41(39)50-40-23-13-12-22-38(40)42(47-50)44(52)49(35-18-6-2-7-19-35)36-20-8-3-9-21-36/h1-25,27,37,46H,26,28-30,45H2/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 70.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341081
PNG
(1-{2-[(3S)-3-[(Dimethylamino)methyl]-1,2,3,4-tetra...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C40H36N4O3/c1-41(2)26-32-24-28-12-6-7-13-29(28)25-42(32)39(46)35-17-9-11-19-38(35)43-27-36(34-16-8-10-18-37(34)43)40(47)44(30-14-4-3-5-15-30)31-20-22-33(45)23-21-31/h3-23,27,32,45H,24-26H2,1-2H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 71.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341103
PNG
(1-{5-Chloro-2-[(3S)-3-(piperidin-1-ylmethyl)-1,2,3...)
Show SMILES Oc1ccc(cc1)N(C(=O)c1cn(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCCCC2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C43H39ClN4O3/c44-32-17-22-38(42(50)46-27-31-12-6-5-11-30(31)25-35(46)28-45-23-9-2-10-24-45)41(26-32)47-29-39(37-15-7-8-16-40(37)47)43(51)48(33-13-3-1-4-14-33)34-18-20-36(49)21-19-34/h1,3-8,11-22,26,29,35,49H,2,9-10,23-25,27-28H2/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 71.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340953
PNG
(1-(4,5-Difluoro-2-{[(3S)-3-[(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(F)c(F)cc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H39F2N5O3/c1-27-20-30(39(49)47(31-10-4-3-5-11-31)32-12-14-34(48)15-13-32)25-45(27)38-23-37(42)36(41)22-35(38)40(50)46-24-29-9-7-6-8-28(29)21-33(46)26-44-18-16-43(2)17-19-44/h3-15,20,22-23,25,33,48H,16-19,21,24,26H2,1-2H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 74.3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341014
PNG
(N-(1H-Indazol-5-yl)-N-(4-methylphenyl)-1-(6-{[(3S)...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc4[nH]ncc4c3)c3ccccc23)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 79.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341028
PNG
(N-(3-Chloro-4-hydroxyphenyl)-N-(1-methyl-1H-indol-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)c(Cl)c3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1
Show InChI InChI=1S/C47H43ClN6O5/c1-49-17-19-51(20-18-49)27-35-21-30-7-3-4-8-32(30)26-52(35)46(56)37-24-44-45(59-29-58-44)25-42(37)53-28-38(36-9-5-6-10-41(36)53)47(57)54(34-12-14-43(55)39(48)23-34)33-11-13-40-31(22-33)15-16-50(40)2/h3-16,22-25,28,35,55H,17-21,26-27,29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 83.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341025
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4,4-difluoropiperidin-1-yl...)
Show SMILES Cc1cc(cn1-c1cc(Br)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCC(F)(F)CC1)C(=O)N(c1ccc(O)cc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 85.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340970
PNG
(1-(4-Chloro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)me...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(Cl)ccc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C40H40ClN5O3/c1-28-22-31(39(48)46(33-10-4-3-5-11-33)34-13-15-36(47)16-14-34)26-44(28)38-17-12-32(41)24-37(38)40(49)45-25-30-9-7-6-8-29(30)23-35(45)27-43-20-18-42(2)19-21-43/h3-17,22,24,26,35,47H,18-21,23,25,27H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 87.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341071
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1cc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C38H32N4O2/c39-24-31-23-27-13-7-8-14-28(27)25-40(31)37(43)33-20-10-12-22-36(33)41-26-34(32-19-9-11-21-35(32)41)38(44)42(29-15-3-1-4-16-29)30-17-5-2-6-18-30/h1-22,26,31H,23-25,39H2/t31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341049
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)car...)
Show SMILES CN1CCN(CC1)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Br)cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 99.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341101
PNG
(N-(4-Hydroxyphenyl)-1-{5-methoxy-2-[(3S)-3-(piperi...)
Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCCCC2)c(c1)-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C44H42N4O4/c1-52-37-22-23-39(43(50)46-28-32-13-7-6-12-31(32)26-35(46)29-45-24-10-3-11-25-45)42(27-37)47-30-40(38-16-8-9-17-41(38)47)44(51)48(33-14-4-2-5-15-33)34-18-20-36(49)21-19-34/h2,4-9,12-23,27,30,35,49H,3,10-11,24-26,28-29H2,1H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 108n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341114
PNG
(1-{2,2-Difluoro-6-[(3S)-3-[(4-methylpiperazin-1-yl...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OC(F)(F)Oc3cc2-n2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H39F2N5O5/c1-47-19-21-48(22-20-47)27-33-23-29-9-5-6-10-30(29)26-49(33)42(53)36-24-40-41(56-44(45,46)55-40)25-39(36)50-28-37(35-13-7-8-14-38(35)50)43(54)51(31-11-3-2-4-12-31)32-15-17-34(52)18-16-32/h2-18,24-25,28,33,52H,19-23,26-27H2,1H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 111n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340858
PNG
(1-[2-{[(3S)-3-[(Dimethylamino)methyl]-3,4-dihydroi...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(cc1-n1cc(cc1C)C(=O)N(c1ccccc1)c1ccc(O)cc1)C(F)(F)F
Show InChI InChI=1S/C38H35F3N4O3/c1-25-19-28(36(47)45(30-11-5-4-6-12-30)31-14-16-33(46)17-15-31)23-43(25)35-21-29(38(39,40)41)13-18-34(35)37(48)44-22-27-10-8-7-9-26(27)20-32(44)24-42(2)3/h4-19,21,23,32,46H,20,22,24H2,1-3H3/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340857
PNG
(1-(2-{[(3S)-3-[(Dimethylamino)methyl]-3,4-dihydroi...)
Show SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1cc(cc1C)C(=O)N(c1ccccc1)c1ccc2[nH]ccc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 146n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341128
PNG
(N,N-Dibutyl-1-{2-[(3S)-3-[(4-methylpiperazin-1-yl)...)
Show SMILES CCCCN(CCCC)C(=O)c1cn(-c2ccc(NC(=O)COc3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C47H56N6O4/c1-4-6-23-51(24-7-5-2)46(55)42-33-53(43-20-14-13-19-40(42)43)44-22-21-37(48-45(54)34-57-39-17-9-8-10-18-39)30-41(44)47(56)52-31-36-16-12-11-15-35(36)29-38(52)32-50-27-25-49(3)26-28-50/h8-22,30,33,38H,4-7,23-29,31-32,34H2,1-3H3,(H,48,54)/t38-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 155n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341008
PNG
(N-(3-Chloro-4-hydroxyphenyl)-N-(4-methylphenyl)-1-...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(O)c(Cl)c3)c3ccccc23)CC1
Show InChI InChI=1S/C45H42ClN5O5/c1-29-11-13-32(14-12-29)51(33-15-16-41(52)38(46)22-33)45(54)37-27-50(39-10-6-5-9-35(37)39)40-24-43-42(55-28-56-43)23-36(40)44(53)49-25-31-8-4-3-7-30(31)21-34(49)26-48-19-17-47(2)18-20-48/h3-16,22-24,27,34,52H,17-21,25-26,28H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 168n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341105
PNG
(N-(4-Hydroxyphenyl)-N-phenyl-1-{2-[(3S)-3-(piperid...)
Show SMILES Oc1ccc(cc1)N(C(=O)c1cn(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCCCC2)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C43H40N4O3/c48-36-23-21-34(22-24-36)47(33-15-3-1-4-16-33)43(50)39-30-46(40-19-9-7-17-37(39)40)41-20-10-8-18-38(41)42(49)45-28-32-14-6-5-13-31(32)27-35(45)29-44-25-11-2-12-26-44/h1,3-10,13-24,30,35,48H,2,11-12,25-29H2/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 168n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341004
PNG
(4-[(4-Methylphenyl){[1-(6-{[(3S)-3-[(4-methylpiper...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(OC(C)=O)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C47H45N5O6/c1-31-12-14-35(15-13-31)52(36-16-18-38(19-17-36)58-32(2)53)47(55)41-29-51(42-11-7-6-10-39(41)42)43-26-45-44(56-30-57-45)25-40(43)46(54)50-27-34-9-5-4-8-33(34)24-37(50)28-49-22-20-48(3)21-23-49/h4-19,25-26,29,37H,20-24,27-28,30H2,1-3H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 206n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340852
PNG
(1-(2-{[(3S)-3-(Aminomethyl)-3,4-dihydroisoquinolin...)
Show SMILES Cc1cc(cn1-c1ccccc1C(=O)N1Cc2ccccc2C[C@H]1CN)C(=O)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H32N4O2/c1-25-20-28(34(40)39(29-14-4-2-5-15-29)30-16-6-3-7-17-30)24-37(25)33-19-11-10-18-32(33)35(41)38-23-27-13-9-8-12-26(27)21-31(38)22-36/h2-20,24,31H,21-23,36H2,1H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 213n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341089
PNG
(1-{4-Amino-2-[(3S)-3-(aminomethyl)-1,2,3,4-tetrahy...)
Show SMILES COc1cc(c(cc1N)C(=O)N1Cc2ccccc2C[C@H]1CN)-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C38H34N6O3/c1-47-35-22-34(31(21-32(35)40)37(45)42-24-26-13-9-8-12-25(26)20-29(42)23-39)44-33-19-11-10-18-30(33)36(41-44)38(46)43(27-14-4-2-5-15-27)28-16-6-3-7-17-28/h2-19,21-22,29H,20,23-24,39-40H2,1H3/t29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 218n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340983
PNG
(1-(5-Bromo-2-{[(3S)-3-[(3aR,6aS)-hexahydrocyclopen...)
Show SMILES Cc1cc(cn1-c1cc(Br)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1C[C@@H]2CCC[C@@H]2C1)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C42H41BrN4O3/c1-28-20-33(41(49)47(35-12-3-2-4-13-35)36-15-17-38(48)18-16-36)26-45(28)40-22-34(43)14-19-39(40)42(50)46-25-32-9-6-5-8-29(32)21-37(46)27-44-23-30-10-7-11-31(30)24-44/h2-6,8-9,12-20,22,26,30-31,37,48H,7,10-11,21,23-25,27H2,1H3/t30-,31+,37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 238n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340915
PNG
(N-(4-Hydroxyphenyl)-5-methyl-1-[2-{[(3S)-3-[(4-met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(OC(F)(F)F)ccc2-n2cc(cc2C)C(=O)N(c2ccccc2)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C41H40F3N5O4/c1-28-22-31(39(51)49(32-10-4-3-5-11-32)33-12-14-35(50)15-13-33)26-47(28)38-17-16-36(53-41(42,43)44)24-37(38)40(52)48-25-30-9-7-6-8-29(30)23-34(48)27-46-20-18-45(2)19-21-46/h3-17,22,24,26,34,50H,18-21,23,25,27H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 245n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341090
PNG
(1-{6-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-n1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2ccccc12
Show InChI InChI=1S/C39H32N4O5/c40-21-29-18-25-8-4-5-9-26(25)22-41(29)38(45)32-19-36-37(48-24-47-36)20-35(32)42-23-33(31-12-6-7-13-34(31)42)39(46)43(27-10-2-1-3-11-27)28-14-16-30(44)17-15-28/h1-17,19-20,23,29,44H,18,21-22,24,40H2/t29-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 286n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341009
PNG
(N-(3-Chloro-4-hydroxyphenyl)-1-(6-{[(3S)-3-[(4-met...)
Show SMILES CC(C)c1ccc(cc1)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C47H46ClN5O5/c1-30(2)31-12-14-34(15-13-31)53(35-16-17-43(54)40(48)23-35)47(56)39-28-52(41-11-7-6-10-37(39)41)42-25-45-44(57-29-58-45)24-38(42)46(55)51-26-33-9-5-4-8-32(33)22-36(51)27-50-20-18-49(3)19-21-50/h4-17,23-25,28,30,36,54H,18-22,26-27,29H2,1-3H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 296n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341069
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES CCCCN(CCCC)C(=O)c1nn(-c2ccccc2C(=O)N2Cc3ccccc3C[C@H]2CN)c2ccccc12
Show InChI InChI=1S/C33H39N5O2/c1-3-5-19-36(20-6-4-2)33(40)31-27-15-9-11-17-29(27)38(35-31)30-18-12-10-16-28(30)32(39)37-23-25-14-8-7-13-24(25)21-26(37)22-34/h7-18,26H,3-6,19-23,34H2,1-2H3/t26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 448n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341074
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES NC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(cc12)C(O)=O
Show InChI InChI=1S/C38H31N5O4/c39-23-30-21-25-11-7-8-12-27(25)24-41(30)36(44)32-17-9-10-18-33(32)43-34-22-26(38(46)47)19-20-31(34)35(40-43)37(45)42(28-13-3-1-4-14-28)29-15-5-2-6-16-29/h1-20,22,30H,21,23-24,39H2,(H,46,47)/t30-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 841n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM340981
PNG
(N-(4-Chlorophenyl)-1-(6-{[(3S)-3-[(4-methylpiperaz...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(CCc3ccccc3)c3ccc(Cl)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C46H44ClN5O4/c1-48-21-23-49(24-22-48)29-37-25-33-11-5-6-12-34(33)28-51(37)45(53)39-26-43-44(56-31-55-43)27-42(39)52-30-40(38-13-7-8-14-41(38)52)46(54)50(36-17-15-35(47)16-18-36)20-19-32-9-3-2-4-10-32/h2-18,26-27,30,37H,19-25,28-29,31H2,1H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 1.11E+3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341046
PNG
(N-(4-Methylphenyl)-1-(6-{[(3S)-3-[(4-methylpiperaz...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(C3CCNCC3)c3ccc(C)cc3)c3ccccc23)CC1
Show InChI InChI=1S/C44H48N6O4/c1-30-11-13-33(14-12-30)50(34-15-17-45-18-16-34)44(52)38-28-49(39-10-6-5-9-36(38)39)40-25-42-41(53-29-54-42)24-37(40)43(51)48-26-32-8-4-3-7-31(32)23-35(48)27-47-21-19-46(2)20-22-47/h3-14,24-25,28,34-35,45H,15-23,26-27,29H2,1-2H3/t35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM341075
PNG
(1-{2-[(3S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoqu...)
Show SMILES COc1cc(c(cc1OCc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1CN)-n1nc(C(=O)N(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C45H39N5O4/c1-53-41-27-40(50-39-24-14-13-23-37(39)43(47-50)45(52)49(34-19-7-3-8-20-34)35-21-9-4-10-22-35)38(26-42(41)54-30-31-15-5-2-6-16-31)44(51)48-29-33-18-12-11-17-32(33)25-36(48)28-46/h2-24,26-27,36H,25,28-30,46H2,1H3/t36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a 2.22E+4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...


US Patent US9765056 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%