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Patent code US9765068

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337029
PNG
(US9745291, Compound 75 | US9765068, Compound 75)
Show SMILES OC(CNC(=O)COc1cccc(CN2CCOCC2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O4/c29-23(18-28-9-8-21-5-1-2-6-22(21)17-28)15-26-25(30)19-32-24-7-3-4-20(14-24)16-27-10-12-31-13-11-27/h1-7,14,23,29H,8-13,15-19H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337030
PNG
(US9745291, Compound 76 | US9765068, Compound 76)
Show SMILES C[C@H](Oc1cccc2cccnc12)C(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337031
PNG
(US9745291, Compound 77 | US9765068, Compound 77)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O4/c28-21(17-26-10-9-19-5-1-2-6-20(19)16-26)15-25-24(29)18-31-23-8-4-3-7-22(23)27-11-13-30-14-12-27/h1-8,21,28H,9-18H2,(H,25,29)/t21-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337062
PNG
(US9745291, Compound 108 | US9765068, Compound 108)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H34N4O5S/c1-27-12-14-29(15-13-27)35(32,33)24-9-5-4-8-23(24)34-19-25(31)26-16-22(30)18-28-11-10-20-6-2-3-7-21(20)17-28/h2-9,22,30H,10-19H2,1H3,(H,26,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337064
PNG
(US9745291, Compound 110 | US9765068, Compound 110)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O5S/c28-21(17-26-14-11-19-7-1-2-8-20(19)16-26)15-25-24(29)18-32-22-9-3-4-10-23(22)33(30,31)27-12-5-6-13-27/h1-4,7-10,21,28H,5-6,11-18H2,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337065
PNG
(US9745291, Compound 111 | US9765068, Compound 111)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCC(O)C1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O6S/c28-20-10-12-27(16-20)34(31,32)23-8-4-3-7-22(23)33-17-24(30)25-13-21(29)15-26-11-9-18-5-1-2-6-19(18)14-26/h1-8,20-21,28-29H,9-17H2,(H,25,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336980
PNG
(US9745291, Compound 26 | US9765068, Compound 26)
Show SMILES Cc1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H26N2O3/c1-16-5-4-8-20(11-16)26-15-21(25)22-12-19(24)14-23-10-9-17-6-2-3-7-18(17)13-23/h2-8,11,19,24H,9-10,12-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336997
PNG
(US9745291, Compound 43 | US9765068, Compound 43)
Show SMILES CC(C)(Oc1cccc2cccnc12)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H29N3O3/c1-25(2,31-22-11-5-9-19-10-6-13-26-23(19)22)24(30)27-15-21(29)17-28-14-12-18-7-3-4-8-20(18)16-28/h3-11,13,21,29H,12,14-17H2,1-2H3,(H,27,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337035
PNG
(US9745291, Compound 81 | US9765068, Compound 81)
Show SMILES CN1CCOc2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C23H29N3O4/c1-25-11-12-29-20-7-4-8-21(23(20)25)30-16-22(28)24-13-19(27)15-26-10-9-17-5-2-3-6-18(17)14-26/h2-8,19,27H,9-16H2,1H3,(H,24,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337117
PNG
(US9745291, Compound 163 | US9765068, Compound 163)
Show SMILES Cc1cn(C)c2cccc(OCC(=O)NC[C@H](O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C24H29N3O3/c1-17-13-26(2)21-8-5-9-22(24(17)21)30-16-23(29)25-12-20(28)15-27-11-10-18-6-3-4-7-19(18)14-27/h3-9,13,20,28H,10-12,14-16H2,1-2H3,(H,25,29)/t20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337122
PNG
(US9745291, Compound 168 | US9765068, Compound 168)
Show SMILES Nc1ncnc2c(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cccc12
Show InChI InChI=1S/C22H25N5O3/c23-22-18-6-3-7-19(21(18)25-14-26-22)30-13-20(29)24-10-17(28)12-27-9-8-15-4-1-2-5-16(15)11-27/h1-7,14,17,28H,8-13H2,(H,24,29)(H2,23,25,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337135
PNG
(US9745291, Compound 181 | US9765068, Compound 181)
Show SMILES OC(CNC(=O)COc1cccc2cncnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c27-19(13-26-9-8-16-4-1-2-5-18(16)12-26)11-24-21(28)14-29-20-7-3-6-17-10-23-15-25-22(17)20/h1-7,10,15,19,27H,8-9,11-14H2,(H,24,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336958
PNG
(US9745291, Compound 4 | US9765068, Compound 4)
Show SMILES OC(CNC(=O)COc1cccc2N(Cc3ccccc3)CCCc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C30H35N3O3/c34-26(21-32-17-15-24-10-4-5-11-25(24)20-32)18-31-30(35)22-36-29-14-6-13-28-27(29)12-7-16-33(28)19-23-8-2-1-3-9-23/h1-6,8-11,13-14,26,34H,7,12,15-22H2,(H,31,35)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336973
PNG
(US9745291, Compound 19 | US9765068, Compound 19)
Show SMILES CC(Oc1ccccc1)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O3/c1-16(26-20-9-3-2-4-10-20)21(25)22-13-19(24)15-23-12-11-17-7-5-6-8-18(17)14-23/h2-10,16,19,24H,11-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336974
PNG
(US9745291, Compound 20 | US9765068, Compound 20)
Show SMILES COc1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H26N2O4/c1-26-19-7-4-8-20(11-19)27-15-21(25)22-12-18(24)14-23-10-9-16-5-2-3-6-17(16)13-23/h2-8,11,18,24H,9-10,12-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336981
PNG
(US9745291, Compound 27 | US9765068, Compound 27)
Show SMILES CN(C)c1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C22H29N3O3/c1-24(2)19-8-5-9-21(12-19)28-16-22(27)23-13-20(26)15-25-11-10-17-6-3-4-7-18(17)14-25/h3-9,12,20,26H,10-11,13-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337020
PNG
(US9745291, Compound 66 | US9765068, Compound 66)
Show SMILES OC(CNC(=O)COc1cccc2ccccc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H26N2O3/c27-21(16-26-13-12-18-6-1-2-8-20(18)15-26)14-25-24(28)17-29-23-11-5-9-19-7-3-4-10-22(19)23/h1-11,21,27H,12-17H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337036
PNG
(US9745291, Compound 82 | US9765068, Compound 82)
Show SMILES Cn1ncc2c(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cccc12
Show InChI InChI=1S/C22H26N4O3/c1-25-20-7-4-8-21(19(20)12-24-25)29-15-22(28)23-11-18(27)14-26-10-9-16-5-2-3-6-17(16)13-26/h2-8,12,18,27H,9-11,13-15H2,1H3,(H,23,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337045
PNG
(US9745291, Compound 91 | US9765068, Compound 91)
Show SMILES OC(CNC(=O)COc1cccc2CNCCc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-20(15-26-11-9-17-4-1-2-5-19(17)14-26)13-25-23(28)16-29-22-7-3-6-18-12-24-10-8-21(18)22/h1-7,20,24,27H,8-16H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337046
PNG
(US9745291, Compound 92 | US9765068, Compound 92)
Show SMILES OC(CNC(=O)COc1cccc2nccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c27-18(14-26-11-8-16-4-1-2-5-17(16)13-26)12-25-21(28)15-29-20-7-3-6-19-22(20)24-10-9-23-19/h1-7,9-10,18,27H,8,11-15H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337057
PNG
(US9745291, Compound 103 | US9765068, Compound 103)
Show SMILES OC(CNC(=O)COc1ccccc1C1CCNCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O3/c29-22(17-28-14-11-19-5-1-2-6-21(19)16-28)15-27-25(30)18-31-24-8-4-3-7-23(24)20-9-12-26-13-10-20/h1-8,20,22,26,29H,9-18H2,(H,27,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337063
PNG
(US9745291, Compound 109 | US9765068, Compound 109)
Show SMILES CN(C)S(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H29N3O5S/c1-24(2)31(28,29)21-10-6-5-9-20(21)30-16-22(27)23-13-19(26)15-25-12-11-17-7-3-4-8-18(17)14-25/h3-10,19,26H,11-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337113
PNG
(US9745291, Compound 159 | US9765068, Compound 159)
Show SMILES Cn1ncc2ccc(OCC(=O)NC[C@H](O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C22H26N4O3/c1-25-21-10-20(7-6-17(21)11-24-25)29-15-22(28)23-12-19(27)14-26-9-8-16-4-2-3-5-18(16)13-26/h2-7,10-11,19,27H,8-9,12-15H2,1H3,(H,23,28)/t19-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336977
PNG
(US9745291, Compound 23 | US9765068, Compound 23)
Show SMILES Cn1ncc2ccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C22H26N4O3/c1-25-21-10-20(7-6-17(21)11-24-25)29-15-22(28)23-12-19(27)14-26-9-8-16-4-2-3-5-18(16)13-26/h2-7,10-11,19,27H,8-9,12-15H2,1H3,(H,23,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337001
PNG
(US9745291, Compound 47 | US9765068, Compound 47)
Show SMILES CS(=O)(=O)c1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H26N2O5S/c1-29(26,27)20-8-4-7-19(11-20)28-15-21(25)22-12-18(24)14-23-10-9-16-5-2-3-6-17(16)13-23/h2-8,11,18,24H,9-10,12-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337025
PNG
(US9745291, Compound 71 | US9765068, Compound 71)
Show SMILES CN1CCC(CC1)n1ncc2ccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C27H35N5O3/c1-30-11-9-23(10-12-30)32-26-14-25(7-6-21(26)15-29-32)35-19-27(34)28-16-24(33)18-31-13-8-20-4-2-3-5-22(20)17-31/h2-7,14-15,23-24,33H,8-13,16-19H2,1H3,(H,28,34)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337027
PNG
(US9745291, Compound 73 | US9765068, Compound 73)
Show SMILES C[C@@H](Oc1cccc2cccnc12)C(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21+/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337048
PNG
(US9745291, Compound 94 | US9765068, Compound 94)
Show SMILES O[C@@H](CNC(=O)COc1c(CN2CCOCC2)ccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C28H34N4O4/c33-25(19-32-11-9-21-4-1-2-5-23(21)17-32)16-30-26(34)20-36-28-24(18-31-12-14-35-15-13-31)8-7-22-6-3-10-29-27(22)28/h1-8,10,25,33H,9,11-20H2,(H,30,34)/t25-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337049
PNG
(US9745291, Compound 95 | US9765068, Compound 95)
Show SMILES OC(CNC(=O)COc1ccc2n(ncc2c1)C1CCNC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N5O3/c31-22(16-29-10-8-18-3-1-2-4-19(18)15-29)14-27-25(32)17-33-23-5-6-24-20(11-23)12-28-30(24)21-7-9-26-13-21/h1-6,11-12,21-22,26,31H,7-10,13-17H2,(H,27,32)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337050
PNG
(US9745291, Compound 96 | US9765068, Compound 96)
Show SMILES CN1CCC(C1)n1ncc2cc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)ccc12
Show InChI InChI=1S/C26H33N5O3/c1-29-10-9-22(16-29)31-25-7-6-24(12-21(25)13-28-31)34-18-26(33)27-14-23(32)17-30-11-8-19-4-2-3-5-20(19)15-30/h2-7,12-13,22-23,32H,8-11,14-18H2,1H3,(H,27,33)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337052
PNG
(US9745291, Compound 98 | US9765068, Compound 98)
Show SMILES COc1ccc2cccc(OCC(=O)NC[C@@H](O)CN3CCc4ccccc4C3)c2n1
Show InChI InChI=1S/C24H27N3O4/c1-30-23-10-9-18-7-4-8-21(24(18)26-23)31-16-22(29)25-13-20(28)15-27-12-11-17-5-2-3-6-19(17)14-27/h2-10,20,28H,11-16H2,1H3,(H,25,29)/t20-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337053
PNG
(US9745291, Compound 99 | US9765068, Compound 99)
Show SMILES CN1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O3/c1-26-11-10-22-20(14-26)7-4-8-23(22)30-17-24(29)25-13-21(28)16-27-12-9-18-5-2-3-6-19(18)15-27/h2-8,21,28H,9-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337055
PNG
(US9745291, Compound 101 | US9765068, Compound 101)
Show SMILES CC(=O)N1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N3O4/c1-18(29)28-12-10-23-21(15-28)7-4-8-24(23)32-17-25(31)26-13-22(30)16-27-11-9-19-5-2-3-6-20(19)14-27/h2-8,22,30H,9-17H2,1H3,(H,26,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337103
PNG
(US9745291, Compound 149 | US9765068, Compound 149)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O6S/c28-21(17-26-10-9-19-5-1-2-6-20(19)16-26)15-25-24(29)18-33-22-7-3-4-8-23(22)34(30,31)27-11-13-32-14-12-27/h1-8,21,28H,9-18H2,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337112
PNG
(US9745291, Compound 158 | US9765068, Compound 158)
Show SMILES Cc1nn(C)c2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C23H28N4O3/c1-16-23-20(26(2)25-16)8-5-9-21(23)30-15-22(29)24-12-19(28)14-27-11-10-17-6-3-4-7-18(17)13-27/h3-9,19,28H,10-15H2,1-2H3,(H,24,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337118
PNG
(US9745291, Compound 164 | US9765068, Compound 164)
Show SMILES Cc1cn(C)c2cccc(OCC(=O)NC[C@@H](O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C24H29N3O3/c1-17-13-26(2)21-8-5-9-22(24(17)21)30-16-23(29)25-12-20(28)15-27-11-10-18-6-3-4-7-19(18)14-27/h3-9,13,20,28H,10-12,14-16H2,1-2H3,(H,25,29)/t20-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336976
PNG
(US9745291, Compound 22 | US9765068, Compound 22)
Show SMILES COc1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O4/c1-26-19-8-4-5-9-20(19)27-15-21(25)22-12-18(24)14-23-11-10-16-6-2-3-7-17(16)13-23/h2-9,18,24H,10-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336982
PNG
(US9745291, Compound 28 | US9765068, Compound 28)
Show SMILES CS(=O)(=O)Nc1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H27N3O5S/c1-30(27,28)23-18-7-4-8-20(11-18)29-15-21(26)22-12-19(25)14-24-10-9-16-5-2-3-6-17(16)13-24/h2-8,11,19,23,25H,9-10,12-15H2,1H3,(H,22,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337002
PNG
(US9745291, Compound 48 | US9765068, Compound 48)
Show SMILES OC(CNC(=O)COc1cccc2ccc(nc12)N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C27H32N4O4/c32-23(18-30-11-10-20-4-1-2-5-22(20)17-30)16-28-26(33)19-35-24-7-3-6-21-8-9-25(29-27(21)24)31-12-14-34-15-13-31/h1-9,23,32H,10-19H2,(H,28,33)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337003
PNG
(US9745291, Compound 49 | US9765068, Compound 49)
Show SMILES OC(CNC(=O)COc1ccccc1N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O4/c28-21(17-26-10-9-19-5-1-2-6-20(19)16-26)15-25-24(29)18-31-23-8-4-3-7-22(23)27-11-13-30-14-12-27/h1-8,21,28H,9-18H2,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337019
PNG
(US9745291, Compound 65 | US9765068, Compound 65)
Show SMILES NS(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H25N3O5S/c21-29(26,27)19-8-4-3-7-18(19)28-14-20(25)22-11-17(24)13-23-10-9-15-5-1-2-6-16(15)12-23/h1-8,17,24H,9-14H2,(H,22,25)(H2,21,26,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337047
PNG
(US9745291, Compound 93 | US9765068, Compound 93)
Show SMILES OC(CNC(=O)COc1cccc(NC2CCOCC2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O4/c29-23(17-28-11-8-19-4-1-2-5-20(19)16-28)15-26-25(30)18-32-24-7-3-6-22(14-24)27-21-9-12-31-13-10-21/h1-7,14,21,23,27,29H,8-13,15-18H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337059
PNG
(US9745291, Compound 105 | US9765068, Compound 105)
Show SMILES CN(C)c1ccc2cccc(OCC(=O)NC[C@@H](O)CN3CCc4ccccc4C3)c2n1
Show InChI InChI=1S/C25H30N4O3/c1-28(2)23-11-10-19-8-5-9-22(25(19)27-23)32-17-24(31)26-14-21(30)16-29-13-12-18-6-3-4-7-20(18)15-29/h3-11,21,30H,12-17H2,1-2H3,(H,26,31)/t21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337061
PNG
(US9745291, Compound 107 | US9765068, Compound 107)
Show SMILES OC(CNC(=O)COc1ccccc1S(=O)(=O)N1CCNCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N4O5S/c29-21(17-27-12-9-19-5-1-2-6-20(19)16-27)15-26-24(30)18-33-22-7-3-4-8-23(22)34(31,32)28-13-10-25-11-14-28/h1-8,21,25,29H,9-18H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337073
PNG
(US9745291, Compound 119 | US9765068, Compound 119)
Show SMILES OC(CNC(=O)COc1cccc2CCNCc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-20(15-26-11-9-17-4-1-2-5-19(17)14-26)12-25-23(28)16-29-22-7-3-6-18-8-10-24-13-21(18)22/h1-7,20,24,27H,8-16H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337077
PNG
(US9745291, Compound 123 | US9765068, Compound 123)
Show SMILES CNS(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H27N3O5S/c1-22-30(27,28)20-9-5-4-8-19(20)29-15-21(26)23-12-18(25)14-24-11-10-16-6-2-3-7-17(16)13-24/h2-9,18,22,25H,10-15H2,1H3,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337107
PNG
(US9745291, Compound 153 | US9765068, Compound 153)
Show SMILES Cn1cnc(c1)-c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O3/c1-27-15-22(26-17-27)21-8-4-5-9-23(21)31-16-24(30)25-12-20(29)14-28-11-10-18-6-2-3-7-19(18)13-28/h2-9,15,17,20,29H,10-14,16H2,1H3,(H,25,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337109
PNG
(US9745291, Compound 155 | US9765068, Compound 155)
Show SMILES CN(c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1)S(C)(=O)=O
Show InChI InChI=1S/C22H29N3O5S/c1-24(31(2,28)29)20-9-5-6-10-21(20)30-16-22(27)23-13-19(26)15-25-12-11-17-7-3-4-8-18(17)14-25/h3-10,19,26H,11-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337124
PNG
(US9745291, Compound 170 | US9765068, Compound 170)
Show SMILES CC(NC(=O)COc1ccccc1S(N)(=O)=O)C(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H27N3O5S/c1-15(18(25)13-24-11-10-16-6-2-3-7-17(16)12-24)23-21(26)14-29-19-8-4-5-9-20(19)30(22,27)28/h2-9,15,18,25H,10-14H2,1H3,(H,23,26)(H2,22,27,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337145
PNG
(US9745291, Compound 191 | US9765068, Compound 191)
Show SMILES CN(C)CCN(C)S(=O)(=O)c1ccccc1OCC(=O)NC[C@@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H36N4O5S/c1-27(2)14-15-28(3)35(32,33)24-11-7-6-10-23(24)34-19-25(31)26-16-22(30)18-29-13-12-20-8-4-5-9-21(20)17-29/h4-11,22,30H,12-19H2,1-3H3,(H,26,31)/t22-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336960
PNG
(US9745291, Compound 6 | US9765068, Compound 6)
Show SMILES OC(CNC(=O)COc1cccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H25N3O3/c27-20(15-26-12-10-17-5-1-2-6-19(17)14-26)13-25-22(28)16-29-21-9-3-7-18-8-4-11-24-23(18)21/h1-9,11,20,27H,10,12-16H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337004
PNG
(US9745291, Compound 50 | US9765068, Compound 50)
Show SMILES OC(CNC(=O)COc1ccccc1-c1cc[nH]n1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337038
PNG
(US9745291, Compound 84 | US9765068, Compound 84)
Show SMILES CN1CCN(CC1)c1ccccc1OCC(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H34N4O3/c1-27-12-14-29(15-13-27)23-8-4-5-9-24(23)32-19-25(31)26-16-22(30)18-28-11-10-20-6-2-3-7-21(20)17-28/h2-9,22,30H,10-19H2,1H3,(H,26,31)/t22-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337044
PNG
(US9745291, Compound 90 | US9765068, Compound 90)
Show SMILES CC(=O)N1CCN(CC1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H34N4O4/c1-20(31)29-12-14-30(15-13-29)24-8-4-5-9-25(24)34-19-26(33)27-16-23(32)18-28-11-10-21-6-2-3-7-22(21)17-28/h2-9,23,32H,10-19H2,1H3,(H,27,33)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337056
PNG
(US9745291, Compound 102 | US9765068, Compound 102)
Show SMILES CS(=O)(=O)N1CCc2c(C1)cccc2OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O5S/c1-33(30,31)27-12-10-22-20(15-27)7-4-8-23(22)32-17-24(29)25-13-21(28)16-26-11-9-18-5-2-3-6-19(18)14-26/h2-8,21,28H,9-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337084
PNG
(US9745291, Compound 130 | US9765068, Compound 130)
Show SMILES CN1CCCC(C1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H35N3O3/c1-28-13-6-9-22(16-28)24-10-4-5-11-25(24)32-19-26(31)27-15-23(30)18-29-14-12-20-7-2-3-8-21(20)17-29/h2-5,7-8,10-11,22-23,30H,6,9,12-19H2,1H3,(H,27,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337100
PNG
(US9745291, Compound 146 | US9765068, Compound 146)
Show SMILES Cc1cn(C)c2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C24H29N3O3/c1-17-13-26(2)21-8-5-9-22(24(17)21)30-16-23(29)25-12-20(28)15-27-11-10-18-6-3-4-7-19(18)14-27/h3-9,13,20,28H,10-12,14-16H2,1-2H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337123
PNG
(US9745291, Compound 169 | US9765068, Compound 169)
Show SMILES CN(C)c1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1S(N)(=O)=O
Show InChI InChI=1S/C22H30N4O5S/c1-25(2)19-8-5-9-20(22(19)32(23,29)30)31-15-21(28)24-12-18(27)14-26-11-10-16-6-3-4-7-17(16)13-26/h3-9,18,27H,10-15H2,1-2H3,(H,24,28)(H2,23,29,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336994
PNG
(US9745291, Compound 40 | US9765068, Compound 40)
Show SMILES OC(CNC(=O)COc1ccccc1C1CCCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H34N2O3/c29-23(18-28-15-14-20-8-4-5-11-22(20)17-28)16-27-26(30)19-31-25-13-7-6-12-24(25)21-9-2-1-3-10-21/h4-8,11-13,21,23,29H,1-3,9-10,14-19H2,(H,27,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337018
PNG
(US9745291, Compound 64 | US9765068, Compound 64)
Show SMILES OC(CNC(=O)COc1cccc2CCCCc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H30N2O3/c27-21(16-26-13-12-18-6-1-2-8-20(18)15-26)14-25-24(28)17-29-23-11-5-9-19-7-3-4-10-22(19)23/h1-2,5-6,8-9,11,21,27H,3-4,7,10,12-17H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337022
PNG
(US9745291, Compound 68 | US9765068, Compound 68)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1-c1cc[nH]n1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337034
PNG
(US9745291, Compound 80 | US9765068, Compound 80)
Show SMILES CN1C(=O)COc2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c12
Show InChI InChI=1S/C23H27N3O5/c1-25-22(29)15-31-20-8-4-7-19(23(20)25)30-14-21(28)24-11-18(27)13-26-10-9-16-5-2-3-6-17(16)12-26/h2-8,18,27H,9-15H2,1H3,(H,24,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337040
PNG
(US9745291, Compound 86 | US9765068, Compound 86)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1OCCN1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H35N3O5/c30-23(19-29-10-9-21-5-1-2-6-22(21)18-29)17-27-26(31)20-34-25-8-4-3-7-24(25)33-16-13-28-11-14-32-15-12-28/h1-8,23,30H,9-20H2,(H,27,31)/t23-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337042
PNG
(US9745291, Compound 88 | US9765068, Compound 88)
Show SMILES CN(C)CCOc1ccccc1OCC(=O)NC[C@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H33N3O4/c1-26(2)13-14-30-22-9-5-6-10-23(22)31-18-24(29)25-15-21(28)17-27-12-11-19-7-3-4-8-20(19)16-27/h3-10,21,28H,11-18H2,1-2H3,(H,25,29)/t21-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337144
PNG
(US9745291, Compound 190 | US9765068, Compound 190)
Show SMILES CN1CCN(CC1)c1cccc(OCC(=O)NC[C@@H](O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H34N4O3/c1-27-11-13-29(14-12-27)22-7-4-8-24(15-22)32-19-25(31)26-16-23(30)18-28-10-9-20-5-2-3-6-21(20)17-28/h2-8,15,23,30H,9-14,16-19H2,1H3,(H,26,31)/t23-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336991
PNG
(US9745291, Compound 37 | US9765068, Compound 37)
Show SMILES CS(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O5S/c1-29(26,27)20-9-5-4-8-19(20)28-15-21(25)22-12-18(24)14-23-11-10-16-6-2-3-7-17(16)13-23/h2-9,18,24H,10-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336992
PNG
(US9745291, Compound 38 | US9765068, Compound 38)
Show SMILES CN(C)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H29N3O3/c1-24(2)20-9-5-6-10-21(20)28-16-22(27)23-13-19(26)15-25-12-11-17-7-3-4-8-18(17)14-25/h3-10,19,26H,11-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336999
PNG
(US9745291, Compound 269 | US9745291, Compound 45 |...)
Show SMILES O[C@H](CNC(=O)COc1cccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H25N3O3/c27-20(15-26-12-10-17-5-1-2-6-19(17)14-26)13-25-22(28)16-29-21-9-3-7-18-8-4-11-24-23(18)21/h1-9,11,20,27H,10,12-16H2,(H,25,28)/t20-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337007
PNG
(US9745291, Compound 53 | US9765068, Compound 53)
Show SMILES CS(=O)(=O)Nc1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H27N3O5S/c1-30(27,28)23-19-8-4-5-9-20(19)29-15-21(26)22-12-18(25)14-24-11-10-16-6-2-3-7-17(16)13-24/h2-9,18,23,25H,10-15H2,1H3,(H,22,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337021
PNG
(US9745291, Compound 67 | US9765068, Compound 67)
Show SMILES O[C@H](CNC(=O)COc1ccccc1-c1cc[nH]n1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337024
PNG
(US9745291, Compound 70 | US9765068, Compound 70)
Show SMILES OC(CNC(=O)COc1ccc2cnn(C3CCNCC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H33N5O3/c32-23(17-30-12-9-19-3-1-2-4-21(19)16-30)15-28-26(33)18-34-24-6-5-20-14-29-31(25(20)13-24)22-7-10-27-11-8-22/h1-6,13-14,22-23,27,32H,7-12,15-18H2,(H,28,33)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337028
PNG
(US9745291, Compound 74 | US9765068, Compound 74)
Show SMILES C[C@@H](Oc1cccc2cccnc12)C(=O)NC[C@@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337033
PNG
(US9745291, Compound 79 | US9765068, Compound 79)
Show SMILES OC(CNC(=O)COc1ccccc1N1CCNCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N4O3/c29-21(17-27-12-9-19-5-1-2-6-20(19)16-27)15-26-24(30)18-31-23-8-4-3-7-22(23)28-13-10-25-11-14-28/h1-8,21,25,29H,9-18H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337054
PNG
(US9745291, Compound 100 | US9765068, Compound 100)
Show SMILES OC(CNC(=O)COc1cccc2OCCOc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H26N2O5/c25-18(14-24-9-8-16-4-1-2-5-17(16)13-24)12-23-21(26)15-29-20-7-3-6-19-22(20)28-11-10-27-19/h1-7,18,25H,8-15H2,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337129
PNG
(US9745291, Compound 175 | US9745291, Compound 251 ...)
Show SMILES O[C@@H](CNC(=O)CCc1nc2ccccc2[nH]1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336993
PNG
(US9745291, Compound 39 | US9765068, Compound 39)
Show SMILES CC(Oc1cccc2cccnc12)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336955
PNG
(US9745291, Compound 1 | US9765068, Compound 1)
Show SMILES OC(CNC(=O)COc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H24N2O3/c23-18(12-21-20(24)15-25-19-8-2-1-3-9-19)14-22-11-10-16-6-4-5-7-17(16)13-22/h1-9,18,23H,10-15H2,(H,21,24)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337119
PNG
(US9745291, Compound 165 | US9765068, Compound 165)
Show SMILES OC(CNC(=O)C(O)c1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H24N2O3/c23-18(12-21-20(25)19(24)16-7-2-1-3-8-16)14-22-11-10-15-6-4-5-9-17(15)13-22/h1-9,18-19,23-24H,10-14H2,(H,21,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336975
PNG
(US9745291, Compound 21 | US9765068, Compound 21)
Show SMILES CC(=O)Nc1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C22H27N3O4/c1-16(26)24-19-6-8-21(9-7-19)29-15-22(28)23-12-20(27)14-25-11-10-17-4-2-3-5-18(17)13-25/h2-9,20,27H,10-15H2,1H3,(H,23,28)(H,24,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336990
PNG
(US9745291, Compound 36 | US9765068, Compound 36)
Show SMILES CC(=O)Nc1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H27N3O4/c1-16(26)24-20-8-4-5-9-21(20)29-15-22(28)23-12-19(27)14-25-11-10-17-6-2-3-7-18(17)13-25/h2-9,19,27H,10-15H2,1H3,(H,23,28)(H,24,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336998
PNG
(US9745291, Compound 44 | US9765068, Compound 44)
Show SMILES O[C@@H](CNC(=O)COc1cccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H25N3O3/c27-20(15-26-12-10-17-5-1-2-6-19(17)14-26)13-25-22(28)16-29-21-9-3-7-18-8-4-11-24-23(18)21/h1-9,11,20,27H,10,12-16H2,(H,25,28)/t20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337008
PNG
(US9745291, Compound 54 | US9765068, Compound 54)
Show SMILES Cn1nccc1-c1cccc(CC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C24H28N4O2/c1-27-23(9-11-26-27)20-8-4-5-18(13-20)14-24(30)25-15-22(29)17-28-12-10-19-6-2-3-7-21(19)16-28/h2-9,11,13,22,29H,10,12,14-17H2,1H3,(H,25,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337074
PNG
(US9745291, Compound 120 | US9765068, Compound 120)
Show SMILES CN1CCc2cccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)c2C1
Show InChI InChI=1S/C24H31N3O3/c1-26-11-9-19-7-4-8-23(22(19)16-26)30-17-24(29)25-13-21(28)15-27-12-10-18-5-2-3-6-20(18)14-27/h2-8,21,28H,9-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337076
PNG
(US9745291, Compound 122 | US9765068, Compound 122)
Show SMILES CC(=O)N1CCN(CC1)S(=O)(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H34N4O6S/c1-20(31)29-12-14-30(15-13-29)37(34,35)25-9-5-4-8-24(25)36-19-26(33)27-16-23(32)18-28-11-10-21-6-2-3-7-22(21)17-28/h2-9,23,32H,10-19H2,1H3,(H,27,33)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337136
PNG
(US9745291, Compound 182 | US9765068, Compound 182)
Show SMILES O[C@@H](CNC(=O)Cc1c[nH]c2ccccc12)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337137
PNG
(US9745291, Compound 183 | US9765068, Compound 183)
Show SMILES O[C@@H](CNC(=O)C1COc2ccccc2O1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H24N2O4/c24-17(13-23-10-9-15-5-1-2-6-16(15)12-23)11-22-21(25)20-14-26-18-7-3-4-8-19(18)27-20/h1-8,17,20,24H,9-14H2,(H,22,25)/t17-,20?/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336962
PNG
(US9745291, Compound 8 | US9765068, Compound 8)
Show SMILES OC(CNC(=O)COc1cccc(c1)C#N)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23N3O3/c22-11-16-4-3-7-20(10-16)27-15-21(26)23-12-19(25)14-24-9-8-17-5-1-2-6-18(17)13-24/h1-7,10,19,25H,8-9,12-15H2,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336965
PNG
(US9745291, Compound 11 | US9765068, Compound 11)
Show SMILES OC(CNC(=O)COc1ccc(cc1)C#N)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23N3O3/c22-11-16-5-7-20(8-6-16)27-15-21(26)23-12-19(25)14-24-10-9-17-3-1-2-4-18(17)13-24/h1-8,19,25H,9-10,12-15H2,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336971
PNG
(US9745291, Compound 17 | US9765068, Compound 17)
Show SMILES OC(CNC(=O)COc1ccccc1C#N)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H23N3O3/c22-11-17-6-3-4-8-20(17)27-15-21(26)23-12-19(25)14-24-10-9-16-5-1-2-7-18(16)13-24/h1-8,19,25H,9-10,12-15H2,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337043
PNG
(US9745291, Compound 89 | US9765068, Compound 89)
Show SMILES CN(C)CCOc1ccccc1OCC(=O)NC[C@@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H33N3O4/c1-26(2)13-14-30-22-9-5-6-10-23(22)31-18-24(29)25-15-21(28)17-27-12-11-19-7-3-4-8-20(19)16-27/h3-10,21,28H,11-18H2,1-2H3,(H,25,29)/t21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337067
PNG
(US9745291, Compound 113 | US9765068, Compound 113)
Show SMILES CN(C)C(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O4/c1-25(2)23(29)20-9-5-6-10-21(20)30-16-22(28)24-13-19(27)15-26-12-11-17-7-3-4-8-18(17)14-26/h3-10,19,27H,11-16H2,1-2H3,(H,24,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337081
PNG
(US9745291, Compound 127 | US9765068, Compound 127)
Show SMILES CN(C)c1ncccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H28N4O3/c1-24(2)21-19(8-5-10-22-21)28-15-20(27)23-12-18(26)14-25-11-9-16-6-3-4-7-17(16)13-25/h3-8,10,18,26H,9,11-15H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337126
PNG
(US9745291, Compound 172 | US9765068, Compound 172)
Show SMILES OC(CNC(=O)COc1cncc(CN2CCOCC2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N4O4/c29-22(17-28-6-5-20-3-1-2-4-21(20)16-28)13-26-24(30)18-32-23-11-19(12-25-14-23)15-27-7-9-31-10-8-27/h1-4,11-12,14,22,29H,5-10,13,15-18H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336963
PNG
(US9745291, Compound 9 | US9765068, Compound 9)
Show SMILES Cc1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C21H26N2O3/c1-16-6-8-20(9-7-16)26-15-21(25)22-12-19(24)14-23-11-10-17-4-2-3-5-18(17)13-23/h2-9,19,24H,10-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336986
PNG
(US9745291, Compound 32 | US9765068, Compound 32)
Show SMILES O[C@@H](CNC(=O)COc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H24N2O3/c23-18(12-21-20(24)15-25-19-8-2-1-3-9-19)14-22-11-10-16-6-4-5-7-17(16)13-22/h1-9,18,23H,10-15H2,(H,21,24)/t18-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336989
PNG
(US9745291, Compound 35 | US9765068, Compound 35)
Show SMILES CN(C)c1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C22H29N3O3/c1-24(2)19-7-9-21(10-8-19)28-16-22(27)23-13-20(26)15-25-12-11-17-5-3-4-6-18(17)14-25/h3-10,20,26H,11-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337014
PNG
(US9745291, Compound 60 | US9765068, Compound 60)
Show SMILES OC(CNC(=O)Cc1cccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H25N3O2/c27-21(16-26-12-10-17-5-1-2-6-20(17)15-26)14-25-22(28)13-19-8-3-7-18-9-4-11-24-23(18)19/h1-9,11,21,27H,10,12-16H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337037
PNG
(US9745291, Compound 83 | US9765068, Compound 83)
Show SMILES OC(CNC(=O)COc1cccc(c1)C(=O)N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H31N3O5/c29-22(17-27-9-8-19-4-1-2-5-21(19)16-27)15-26-24(30)18-33-23-7-3-6-20(14-23)25(31)28-10-12-32-13-11-28/h1-7,14,22,29H,8-13,15-18H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337060
PNG
(US9745291, Compound 106 | US9765068, Compound 106)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H34N4O5S/c1-35(32,33)29-14-12-28(13-15-29)23-8-4-5-9-24(23)34-19-25(31)26-16-22(30)18-27-11-10-20-6-2-3-7-21(20)17-27/h2-9,22,30H,10-19H2,1H3,(H,26,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337114
PNG
(US9745291, Compound 160 | US9765068, Compound 160)
Show SMILES Cn1ncc2ccc(OCC(=O)NC[C@@H](O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C22H26N4O3/c1-25-21-10-20(7-6-17(21)11-24-25)29-15-22(28)23-12-19(27)14-26-9-8-16-4-2-3-5-18(16)13-26/h2-7,10-11,19,27H,8-9,12-15H2,1H3,(H,23,28)/t19-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337133
PNG
(US9745291, Compound 179 | US9765068, Compound 179)
Show SMILES O[C@@H](CNC(=O)CC1Cc2ccccc2C1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H28N2O2/c26-22(16-25-10-9-18-5-1-4-8-21(18)15-25)14-24-23(27)13-17-11-19-6-2-3-7-20(19)12-17/h1-8,17,22,26H,9-16H2,(H,24,27)/t22-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337139
PNG
(US9745291, Compound 185 | US9765068, Compound 185)
Show SMILES O[C@@H](CNC(=O)[C@H]1Cc2ccccc2CN1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H27N3O2/c26-20(15-25-10-9-16-5-1-4-8-19(16)14-25)13-24-22(27)21-11-17-6-2-3-7-18(17)12-23-21/h1-8,20-21,23,26H,9-15H2,(H,24,27)/t20-,21+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336961
PNG
(US9745291, Compound 7 | US9765068, Compound 7)
Show SMILES OC(CNC(=O)COc1cccc(F)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H23FN2O3/c21-17-6-3-7-19(10-17)26-14-20(25)22-11-18(24)13-23-9-8-15-4-1-2-5-16(15)12-23/h1-7,10,18,24H,8-9,11-14H2,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336988
PNG
(US9745291, Compound 34 | US9765068, Compound 34)
Show SMILES NC(=O)c1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H25N3O4/c22-21(27)16-6-3-7-19(10-16)28-14-20(26)23-11-18(25)13-24-9-8-15-4-1-2-5-17(15)12-24/h1-7,10,18,25H,8-9,11-14H2,(H2,22,27)(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337058
PNG
(US9745291, Compound 104 | US9765068, Compound 104)
Show SMILES CN(C)c1ccc2cccc(OCC(=O)NC[C@H](O)CN3CCc4ccccc4C3)c2n1
Show InChI InChI=1S/C25H30N4O3/c1-28(2)23-11-10-19-8-5-9-22(25(19)27-23)32-17-24(31)26-14-21(30)16-29-13-12-18-6-3-4-7-20(18)15-29/h3-11,21,30H,12-17H2,1-2H3,(H,26,31)/t21-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337066
PNG
(US9745291, Compound 112 | US9765068, Compound 112)
Show SMILES CNC(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H27N3O4/c1-23-22(28)19-8-4-5-9-20(19)29-15-21(27)24-12-18(26)14-25-11-10-16-6-2-3-7-17(16)13-25/h2-9,18,26H,10-15H2,1H3,(H,23,28)(H,24,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337096
PNG
(US9745291, Compound 142 | US9765068, Compound 142)
Show SMILES CN(c1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1)S(C)(=O)=O
Show InChI InChI=1S/C22H29N3O5S/c1-24(31(2,28)29)19-8-5-9-21(12-19)30-16-22(27)23-13-20(26)15-25-11-10-17-6-3-4-7-18(17)14-25/h3-9,12,20,26H,10-11,13-16H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337143
PNG
(US9745291, Compound 189 | US9765068, Compound 189)
Show SMILES O[C@H](CNC(=O)COc1cccc(c1)C(=O)NCCc1c[nH]cn1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336969
PNG
(US9745291, Compound 15 | US9765068, Compound 15)
Show SMILES Cc1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O3/c1-16-6-2-5-9-20(16)26-15-21(25)22-12-19(24)14-23-11-10-17-7-3-4-8-18(17)13-23/h2-9,19,24H,10-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337009
PNG
(US9745291, Compound 55 | US9765068, Compound 55)
Show SMILES O[C@@H](CNC(=O)Cc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H24N2O2/c23-19(13-21-20(24)12-16-6-2-1-3-7-16)15-22-11-10-17-8-4-5-9-18(17)14-22/h1-9,19,23H,10-15H2,(H,21,24)/t19-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337071
PNG
(US9745291, Compound 117 | US9765068, Compound 117)
Show SMILES OC(CNC(=O)COc1ccccc1C1CCCNC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O3/c29-22(17-28-13-11-19-6-1-2-7-21(19)16-28)15-27-25(30)18-31-24-10-4-3-9-23(24)20-8-5-12-26-14-20/h1-4,6-7,9-10,20,22,26,29H,5,8,11-18H2,(H,27,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337088
PNG
(US9745291, Compound 134 | US9765068, Compound 134)
Show SMILES CN1CCC(CC1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H35N3O3/c1-28-13-10-21(11-14-28)24-8-4-5-9-25(24)32-19-26(31)27-16-23(30)18-29-15-12-20-6-2-3-7-22(20)17-29/h2-9,21,23,30H,10-19H2,1H3,(H,27,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337091
PNG
(US9745291, Compound 137 | US9765068, Compound 137)
Show SMILES OC(CNC(=O)COc1ccccc1-c1ncc[nH]1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337105
PNG
(US9745291, Compound 151 | US9765068, Compound 151)
Show SMILES CN1CCCc2c(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cccc12
Show InChI InChI=1S/C24H31N3O3/c1-26-12-5-8-21-22(26)9-4-10-23(21)30-17-24(29)25-14-20(28)16-27-13-11-18-6-2-3-7-19(18)15-27/h2-4,6-7,9-10,20,28H,5,8,11-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337128
PNG
(US9745291, Compound 174 | US9765068, Compound 174)
Show SMILES O[C@@H](CNC(=O)Cc1ccc2OCOc2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H24N2O4/c24-18(13-23-8-7-16-3-1-2-4-17(16)12-23)11-22-21(25)10-15-5-6-19-20(9-15)27-14-26-19/h1-6,9,18,24H,7-8,10-14H2,(H,22,25)/t18-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336984
PNG
(US9745291, Compound 30 | US9765068, Compound 30)
Show SMILES Cn1cnc2ccc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C22H26N4O3/c1-25-15-24-20-7-6-19(10-21(20)25)29-14-22(28)23-11-18(27)13-26-9-8-16-4-2-3-5-17(16)12-26/h2-7,10,15,18,27H,8-9,11-14H2,1H3,(H,23,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337032
PNG
(US9745291, Compound 78 | US9765068, Compound 78)
Show SMILES O[C@H](CNC(=O)COc1ccccc1N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O4/c28-21(17-26-10-9-19-5-1-2-6-20(19)16-26)15-25-24(29)18-31-23-8-4-3-7-22(23)27-11-13-30-14-12-27/h1-8,21,28H,9-18H2,(H,25,29)/t21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337083
PNG
(US9745291, Compound 129 | US9765068, Compound 129)
Show SMILES OC(CNC(=O)COc1cccc2ncc(=O)[nH]c12)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337131
PNG
(US9745291, Compound 177 | US9765068, Compound 177)
Show SMILES O[C@@H](CNC(=O)C1CNc2ccccc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H25N3O2/c25-17(14-24-10-9-15-5-1-2-6-16(15)13-24)11-23-21(26)19-12-22-20-8-4-3-7-18(19)20/h1-8,17,19,22,25H,9-14H2,(H,23,26)/t17-,19?/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337132
PNG
(US9745291, Compound 178 | US9765068, Compound 178)
Show SMILES O[C@@H](CNC(=O)CC1CCc2ccccc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H28N2O2/c26-21(16-25-12-11-17-5-1-2-7-20(17)15-25)14-24-23(27)13-19-10-9-18-6-3-4-8-22(18)19/h1-8,19,21,26H,9-16H2,(H,24,27)/t19?,21-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337146
PNG
(US9745291, Compound 192 | US9765068, Compound 192)
Show SMILES O[C@H](CNC(=O)CCc1nc2ccccc2[nH]1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336970
PNG
(US9745291, Compound 16 | US9765068, Compound 16)
Show SMILES OC(CNC(=O)COc1ccccc1F)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H23FN2O3/c21-18-7-3-4-8-19(18)26-14-20(25)22-11-17(24)13-23-10-9-15-5-1-2-6-16(15)12-23/h1-8,17,24H,9-14H2,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336979
PNG
(US9745291, Compound 25 | US9765068, Compound 25)
Show SMILES CC(C)(Oc1ccccc1)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H28N2O3/c1-22(2,27-20-10-4-3-5-11-20)21(26)23-14-19(25)16-24-13-12-17-8-6-7-9-18(17)15-24/h3-11,19,25H,12-16H2,1-2H3,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336983
PNG
(US9745291, Compound 29 | US9765068, Compound 29)
Show SMILES NC(=O)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H25N3O4/c22-21(27)18-7-3-4-8-19(18)28-14-20(26)23-11-17(25)13-24-10-9-15-5-1-2-6-16(15)12-24/h1-8,17,25H,9-14H2,(H2,22,27)(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337000
PNG
(US9745291, Compound 46 | US9765068, Compound 46)
Show SMILES Cn1cnc2cc(OCC(=O)NCC(O)CN3CCc4ccccc4C3)ccc12
Show InChI InChI=1S/C22H26N4O3/c1-25-15-24-20-10-19(6-7-21(20)25)29-14-22(28)23-11-18(27)13-26-9-8-16-4-2-3-5-17(16)12-26/h2-7,10,15,18,27H,8-9,11-14H2,1H3,(H,23,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337115
PNG
(US9745291, Compound 161 | US9765068, Compound 161)
Show SMILES OC(CNC(=O)COc1cncc(c1)C(=O)N1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H30N4O5/c29-21(16-27-6-5-18-3-1-2-4-19(18)15-27)13-26-23(30)17-33-22-11-20(12-25-14-22)24(31)28-7-9-32-10-8-28/h1-4,11-12,14,21,29H,5-10,13,15-17H2,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336978
PNG
(US9745291, Compound 24 | US9765068, Compound 24)
Show SMILES OC(CNC(=O)COC1CCCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H30N2O3/c23-18(12-21-20(24)15-25-19-8-2-1-3-9-19)14-22-11-10-16-6-4-5-7-17(16)13-22/h4-7,18-19,23H,1-3,8-15H2,(H,21,24)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336996
PNG
(US9745291, Compound 42 | US9765068, Compound 42)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C21H27N3O5S/c1-30(27,28)23-18-6-8-20(9-7-18)29-15-21(26)22-12-19(25)14-24-11-10-16-4-2-3-5-17(16)13-24/h2-9,19,23,25H,10-15H2,1H3,(H,22,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337023
PNG
(US9745291, Compound 69 | US9765068, Compound 69)
Show SMILES Cn1cnc2ccc(NCC(=O)NCC(O)CN3CCc4ccccc4C3)cc12
Show InChI InChI=1S/C22H27N5O2/c1-26-15-25-20-7-6-18(10-21(20)26)23-12-22(29)24-11-19(28)14-27-9-8-16-4-2-3-5-17(16)13-27/h2-7,10,15,19,23,28H,8-9,11-14H2,1H3,(H,24,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337051
PNG
(US9745291, Compound 97 | US9765068, Compound 97)
Show SMILES COc1ccc2cccc(OCC(=O)NC[C@H](O)CN3CCc4ccccc4C3)c2n1
Show InChI InChI=1S/C24H27N3O4/c1-30-23-10-9-18-7-4-8-21(24(18)26-23)31-16-22(29)25-13-20(28)15-27-12-11-17-5-2-3-6-19(17)14-27/h2-10,20,28H,11-16H2,1H3,(H,25,29)/t20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337068
PNG
(US9745291, Compound 114 | US9765068, Compound 114)
Show SMILES CC(Oc1ccccc1S(C)(=O)=O)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H28N2O5S/c1-16(29-20-9-5-6-10-21(20)30(2,27)28)22(26)23-13-19(25)15-24-12-11-17-7-3-4-8-18(17)14-24/h3-10,16,19,25H,11-15H2,1-2H3,(H,23,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337072
PNG
(US9745291, Compound 118 | US9765068, Compound 118)
Show SMILES Cn1cc2c(OCC(=O)NCC(O)CN3CCc4ccccc4C3)cccc2n1
Show InChI InChI=1S/C22H26N4O3/c1-25-14-19-20(24-25)7-4-8-21(19)29-15-22(28)23-11-18(27)13-26-10-9-16-5-2-3-6-17(16)12-26/h2-8,14,18,27H,9-13,15H2,1H3,(H,23,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337092
PNG
(US9745291, Compound 138 | US9765068, Compound 138)
Show SMILES Cn1ccnc1-c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O3/c1-27-13-11-25-24(27)21-8-4-5-9-22(21)31-17-23(30)26-14-20(29)16-28-12-10-18-6-2-3-7-19(18)15-28/h2-9,11,13,20,29H,10,12,14-17H2,1H3,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337104
PNG
(US9745291, Compound 150 | US9765068, Compound 150)
Show SMILES OC(CNC(=O)COc1cccc2NCCCc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-19(15-26-12-10-17-5-1-2-6-18(17)14-26)13-25-23(28)16-29-22-9-3-8-21-20(22)7-4-11-24-21/h1-3,5-6,8-9,19,24,27H,4,7,10-16H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336966
PNG
(US9745291, Compound 12 | US9765068, Compound 12)
Show SMILES COc1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C21H26N2O4/c1-26-19-6-8-20(9-7-19)27-15-21(25)22-12-18(24)14-23-11-10-16-4-2-3-5-17(16)13-23/h2-9,18,24H,10-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336956
PNG
(US9745291, Compound 2 | US9765068, Compound 2)
Show SMILES OC(CNC(=O)CCc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N2O2/c24-20(14-22-21(25)11-10-17-6-2-1-3-7-17)16-23-13-12-18-8-4-5-9-19(18)15-23/h1-9,20,24H,10-16H2,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337078
PNG
(US9745291, Compound 124 | US9765068, Compound 124)
Show SMILES OC(CNC(=O)COc1cccc2NC(=O)COc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H25N3O5/c26-17(12-25-9-8-15-4-1-2-5-16(15)11-25)10-23-20(27)13-29-19-7-3-6-18-22(19)30-14-21(28)24-18/h1-7,17,26H,8-14H2,(H,23,27)(H,24,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337094
PNG
(US9745291, Compound 140 | US9765068, Compound 140)
Show SMILES CS(=O)(=O)Nc1cccnc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H26N4O5S/c1-30(27,28)23-18-7-4-9-21-20(18)29-14-19(26)22-11-17(25)13-24-10-8-15-5-2-3-6-16(15)12-24/h2-7,9,17,23,25H,8,10-14H2,1H3,(H,22,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337106
PNG
(US9745291, Compound 152 | US9765068, Compound 152)
Show SMILES OC(CNC(=O)COCc1cccnc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H25N3O3/c24-19(13-23-9-7-17-5-1-2-6-18(17)12-23)11-22-20(25)15-26-14-16-4-3-8-21-10-16/h1-6,8,10,19,24H,7,9,11-15H2,(H,22,25)
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337108
PNG
(US9745291, Compound 154 | US9765068, Compound 154)
Show SMILES OC(CNC(=O)COc1cccc2cnncc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H24N4O3/c27-19(14-26-9-8-16-4-1-2-5-18(16)13-26)11-23-22(28)15-29-21-7-3-6-17-10-24-25-12-20(17)21/h1-7,10,12,19,27H,8-9,11,13-15H2,(H,23,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337125
PNG
(US9745291, Compound 171 | US9765068, Compound 171)
Show SMILES OC(CNC(=O)COC1CCOC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C18H26N2O4/c21-16(9-19-18(22)13-24-17-6-8-23-12-17)11-20-7-5-14-3-1-2-4-15(14)10-20/h1-4,16-17,21H,5-13H2,(H,19,22)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337130
PNG
(US9745291, Compound 176 | US9765068, Compound 176)
Show SMILES CN1CCN(CCOCC(=O)NCC(O)CN2CCc3ccccc3C2)CC1
Show InChI InChI=1S/C21H34N4O3/c1-23-8-10-24(11-9-23)12-13-28-17-21(27)22-14-20(26)16-25-7-6-18-4-2-3-5-19(18)15-25/h2-5,20,26H,6-17H2,1H3,(H,22,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336985
PNG
(US9745291, Compound 31 | US9765068, Compound 31)
Show SMILES CC(=O)Nc1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C22H27N3O4/c1-16(26)24-19-7-4-8-21(11-19)29-15-22(28)23-12-20(27)14-25-10-9-17-5-2-3-6-18(17)13-25/h2-8,11,20,27H,9-10,12-15H2,1H3,(H,23,28)(H,24,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337075
PNG
(US9745291, Compound 121 | US9765068, Compound 121)
Show SMILES OC(CNC(=O)COc1cccc(NC2CCOCC2)n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N4O4/c29-21(16-28-11-8-18-4-1-2-5-19(18)15-28)14-25-23(30)17-32-24-7-3-6-22(27-24)26-20-9-12-31-13-10-20/h1-7,20-21,29H,8-17H2,(H,25,30)(H,26,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337086
PNG
(US9745291, Compound 132 | US9765068, Compound 132)
Show SMILES OC(CNC(=O)COc1ccccc1C1CNC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H29N3O3/c27-20(15-26-10-9-17-5-1-2-6-18(17)14-26)13-25-23(28)16-29-22-8-4-3-7-21(22)19-11-24-12-19/h1-8,19-20,24,27H,9-16H2,(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337089
PNG
(US9745291, Compound 135 | US9765068, Compound 135)
Show SMILES CN1CC(C1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O3/c1-26-13-20(14-26)22-8-4-5-9-23(22)30-17-24(29)25-12-21(28)16-27-11-10-18-6-2-3-7-19(18)15-27/h2-9,20-21,28H,10-17H2,1H3,(H,25,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337095
PNG
(US9745291, Compound 141 | US9765068, Compound 141)
Show SMILES CC(C)(C)OC(=O)Nc1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O5/c1-25(2,3)33-24(31)27-21-10-6-7-11-22(21)32-17-23(30)26-14-20(29)16-28-13-12-18-8-4-5-9-19(18)15-28/h4-11,20,29H,12-17H2,1-3H3,(H,26,30)(H,27,31)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337097
PNG
(US9745291, Compound 143 | US9765068, Compound 143)
Show SMILES CN(C)c1cncc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H28N4O3/c1-24(2)18-9-20(12-22-10-18)28-15-21(27)23-11-19(26)14-25-8-7-16-5-3-4-6-17(16)13-25/h3-6,9-10,12,19,26H,7-8,11,13-15H2,1-2H3,(H,23,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337099
PNG
(US9745291, Compound 145 | US9765068, Compound 145)
Show SMILES Nc1ncccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C19H24N4O3/c20-19-17(6-3-8-21-19)26-13-18(25)22-10-16(24)12-23-9-7-14-4-1-2-5-15(14)11-23/h1-6,8,16,24H,7,9-13H2,(H2,20,21)(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337111
PNG
(US9745291, Compound 157 | US9765068, Compound 157)
Show SMILES CC(Oc1ccccc1NS(C)(=O)=O)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H29N3O5S/c1-16(30-21-10-6-5-9-20(21)24-31(2,28)29)22(27)23-13-19(26)15-25-12-11-17-7-3-4-8-18(17)14-25/h3-10,16,19,24,26H,11-15H2,1-2H3,(H,23,27)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337116
PNG
(US9745291, Compound 162 | US9765068, Compound 162)
Show SMILES CC(=O)Nc1ccncc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N4O4/c1-15(26)24-19-6-8-22-11-20(19)29-14-21(28)23-10-18(27)13-25-9-7-16-4-2-3-5-17(16)12-25/h2-6,8,11,18,27H,7,9-10,12-14H2,1H3,(H,23,28)(H,22,24,26)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336964
PNG
(US9745291, Compound 10 | US9765068, Compound 10)
Show SMILES OC(CNC(=O)COc1ccc(F)cc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H23FN2O3/c21-17-5-7-19(8-6-17)26-14-20(25)22-11-18(24)13-23-10-9-15-3-1-2-4-16(15)12-23/h1-8,18,24H,9-14H2,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336972
PNG
(US9745291, Compound 18 | US9765068, Compound 18)
Show SMILES OC(CNC(=O)CNc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H25N3O2/c24-19(12-22-20(25)13-21-18-8-2-1-3-9-18)15-23-11-10-16-6-4-5-7-17(16)14-23/h1-9,19,21,24H,10-15H2,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337013
PNG
(US9745291, Compound 59 | US9765068, Compound 59)
Show SMILES N[C@@H](C(=O)NC[C@H](O)CN1CCc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C20H25N3O2/c21-19(16-7-2-1-3-8-16)20(25)22-12-18(24)14-23-11-10-15-6-4-5-9-17(15)13-23/h1-9,18-19,24H,10-14,21H2,(H,22,25)/t18-,19+/m0/s1
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337141
PNG
(US9745291, Compound 187 | US9765068, Compound 187)
Show SMILES Cn1ccnc1-c1cccc(OCC(=O)NC[C@@H](O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C24H28N4O3/c1-27-12-10-25-24(27)19-7-4-8-22(13-19)31-17-23(30)26-14-21(29)16-28-11-9-18-5-2-3-6-20(18)15-28/h2-8,10,12-13,21,29H,9,11,14-17H2,1H3,(H,26,30)/t21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336967
PNG
(US9745291, Compound 13 | US9765068, Compound 13)
Show SMILES NC(=O)c1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C21H25N3O4/c22-21(27)16-5-7-19(8-6-16)28-14-20(26)23-11-18(25)13-24-10-9-15-3-1-2-4-17(15)12-24/h1-8,18,25H,9-14H2,(H2,22,27)(H,23,26)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337039
PNG
(US9745291, Compound 85 | US9765068, Compound 85)
Show SMILES CN1CCN(CC1)c1ccccc1OCC(=O)NC[C@@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H34N4O3/c1-27-12-14-29(15-13-27)23-8-4-5-9-24(23)32-19-25(31)26-16-22(30)18-28-11-10-20-6-2-3-7-21(20)17-28/h2-9,22,30H,10-19H2,1H3,(H,26,31)/t22-/m1/s1
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337085
PNG
(US9745291, Compound 131 | US9765068, Compound 131)
Show SMILES NS(=O)(=O)c1cccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C20H25N3O5S/c21-29(26,27)19-7-3-6-18(10-19)28-14-20(25)22-11-17(24)13-23-9-8-15-4-1-2-5-16(15)12-23/h1-7,10,17,24H,8-9,11-14H2,(H,22,25)(H2,21,26,27)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337147
PNG
(US9745291, Compound 193 | US9765068, Compound 193)
Show SMILES O[C@H](CNC(=O)CCc1nc2ccccc2s1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C22H25N3O2S/c26-18(15-25-12-11-16-5-1-2-6-17(16)14-25)13-23-21(27)9-10-22-24-19-7-3-4-8-20(19)28-22/h1-8,18,26H,9-15H2,(H,23,27)/t18-/m1/s1
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336957
PNG
(US9745291, Compound 3 | US9765068, Compound 3)
Show SMILES CN(CC(O)CN1CCc2ccccc2C1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C22H28N2O2/c1-23(22(26)12-11-18-7-3-2-4-8-18)16-21(25)17-24-14-13-19-9-5-6-10-20(19)15-24/h2-10,21,25H,11-17H2,1H3
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337090
PNG
(US9745291, Compound 136 | US9765068, Compound 136)
Show SMILES CN1CCC(C1)c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H33N3O3/c1-27-12-10-21(15-27)23-8-4-5-9-24(23)31-18-25(30)26-14-22(29)17-28-13-11-19-6-2-3-7-20(19)16-28/h2-9,21-22,29H,10-18H2,1H3,(H,26,30)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337120
PNG
(US9745291, Compound 166 | US9765068, Compound 166)
Show SMILES OC(CNC(=O)COC1CCCOC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C19H28N2O4/c22-17(10-20-19(23)14-25-18-6-3-9-24-13-18)12-21-8-7-15-4-1-2-5-16(15)11-21/h1-2,4-5,17-18,22H,3,6-14H2,(H,20,23)
PDB

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n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337121
PNG
(US9745291, Compound 167 | US9765068, Compound 167)
Show SMILES OC(CNC(=O)COCCN1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H31N3O4/c24-19(15-23-6-5-17-3-1-2-4-18(17)14-23)13-21-20(25)16-27-12-9-22-7-10-26-11-8-22/h1-4,19,24H,5-16H2,(H,21,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337134
PNG
(US9745291, Compound 180 | US9765068, Compound 180)
Show SMILES O[C@@H](CNC(=O)C1CCCc2ccccc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H28N2O2/c26-20(16-25-13-12-17-6-1-2-8-19(17)15-25)14-24-23(27)22-11-5-9-18-7-3-4-10-21(18)22/h1-4,6-8,10,20,22,26H,5,9,11-16H2,(H,24,27)/t20-,22?/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337140
PNG
(US9745291, Compound 186 | US9765068, Compound 186)
Show SMILES O[C@H](CNC(=O)COc1cccc(c1)-c1ncc[nH]1)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336987
PNG
(US9745291, Compound 33 | US9765068, Compound 33)
Show SMILES O[C@H](CNC(=O)COc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H24N2O3/c23-18(12-21-20(24)15-25-19-8-2-1-3-9-19)14-22-11-10-16-6-4-5-7-17(16)13-22/h1-9,18,23H,10-15H2,(H,21,24)/t18-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337010
PNG
(US9745291, Compound 56 | US9765068, Compound 56)
Show SMILES O[C@@H](CNC(=O)CC1CCCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H30N2O2/c23-19(13-21-20(24)12-16-6-2-1-3-7-16)15-22-11-10-17-8-4-5-9-18(17)14-22/h4-5,8-9,16,19,23H,1-3,6-7,10-15H2,(H,21,24)/t19-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337015
PNG
(US9745291, Compound 61 | US9765068, Compound 61)
Show SMILES N[C@@H](C(=O)NC[C@@H](O)CN1CCc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C20H25N3O2/c21-19(16-7-2-1-3-8-16)20(25)22-12-18(24)14-23-11-10-15-6-4-5-9-17(15)13-23/h1-9,18-19,24H,10-14,21H2,(H,22,25)/t18-,19-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337079
PNG
(US9745291, Compound 125 | US9765068, Compound 125)
Show SMILES OC(CNC(=O)COc1cccc2[nH]c(=O)cnc12)CN1CCc2ccccc2C1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337110
PNG
(US9745291, Compound 156 | US9765068, Compound 156)
Show SMILES Cn1cncc1-c1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H28N4O3/c1-27-17-25-13-22(27)21-8-4-5-9-23(21)31-16-24(30)26-12-20(29)15-28-11-10-18-6-2-3-7-19(18)14-28/h2-9,13,17,20,29H,10-12,14-16H2,1H3,(H,26,30)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336995
PNG
(US9745291, Compound 41 | US9765068, Compound 41)
Show SMILES OC(CNC(=O)COC1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C19H28N2O4/c22-17(11-20-19(23)14-25-18-6-9-24-10-7-18)13-21-8-5-15-3-1-2-4-16(15)12-21/h1-4,17-18,22H,5-14H2,(H,20,23)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337016
PNG
(US9745291, Compound 62 | US9765068, Compound 62)
Show SMILES N[C@H](C(=O)NC[C@H](O)CN1CCc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C20H25N3O2/c21-19(16-7-2-1-3-8-16)20(25)22-12-18(24)14-23-11-10-15-6-4-5-9-17(15)13-23/h1-9,18-19,24H,10-14,21H2,(H,22,25)/t18-,19-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337026
PNG
(US9745291, Compound 72 | US9765068, Compound 72)
Show SMILES C[C@H](Oc1cccc2cccnc12)C(=O)NC[C@@H](O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H27N3O3/c1-17(30-22-10-4-8-19-9-5-12-25-23(19)22)24(29)26-14-21(28)16-27-13-11-18-6-2-3-7-20(18)15-27/h2-10,12,17,21,28H,11,13-16H2,1H3,(H,26,29)/t17-,21+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337070
PNG
(US9745291, Compound 116 | US9765068, Compound 116)
Show SMILES OC(CNC(=O)COc1ccccc1C1CCNC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H31N3O3/c28-21(16-27-12-10-18-5-1-2-6-20(18)15-27)14-26-24(29)17-30-23-8-4-3-7-22(23)19-9-11-25-13-19/h1-8,19,21,25,28H,9-17H2,(H,26,29)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337127
PNG
(US9745291, Compound 173 | US9765068, Compound 173)
Show SMILES CC(O)(C(=O)NCC(O)CN1CCc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C21H26N2O3/c1-21(26,18-9-3-2-4-10-18)20(25)22-13-19(24)15-23-12-11-16-7-5-6-8-17(16)14-23/h2-10,19,24,26H,11-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337138
PNG
(US9745291, Compound 184 | US9765068, Compound 184)
Show SMILES O[C@@H](CNC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H31N3O2/c25-18(14-24-10-9-15-5-1-2-7-17(15)13-24)12-22-21(26)20-11-16-6-3-4-8-19(16)23-20/h1-2,5,7,16,18-20,23,25H,3-4,6,8-14H2,(H,22,26)/t16-,18-,19-,20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336968
PNG
(US9745291, Compound 14 | US9765068, Compound 14)
Show SMILES CS(=O)(=O)c1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C21H26N2O5S/c1-29(26,27)20-8-6-19(7-9-20)28-15-21(25)22-12-18(24)14-23-11-10-16-4-2-3-5-17(16)13-23/h2-9,18,24H,10-15H2,1H3,(H,22,25)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337006
PNG
(US9745291, Compound 52 | US9765068, Compound 52)
Show SMILES NS(=O)(=O)c1ccc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C20H25N3O5S/c21-29(26,27)19-7-5-18(6-8-19)28-14-20(25)22-11-17(24)13-23-10-9-15-3-1-2-4-16(15)12-23/h1-8,17,24H,9-14H2,(H,22,25)(H2,21,26,27)
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337041
PNG
(US9745291, Compound 87 | US9765068, Compound 87)
Show SMILES O[C@H](CNC(=O)COc1ccccc1OCCN1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C26H35N3O5/c30-23(19-29-10-9-21-5-1-2-6-22(21)18-29)17-27-26(31)20-34-25-8-4-3-7-24(25)33-16-13-28-11-14-32-15-12-28/h1-8,23,30H,9-20H2,(H,27,31)/t23-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337142
PNG
(US9745291, Compound 188 | US9765068, Compound 188)
Show SMILES O[C@H](CNC(=O)COc1cccc(c1)C(=O)NCCN1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C27H36N4O5/c32-24(19-31-10-8-21-4-1-2-5-23(21)18-31)17-29-26(33)20-36-25-7-3-6-22(16-25)27(34)28-9-11-30-12-14-35-15-13-30/h1-7,16,24,32H,8-15,17-20H2,(H,28,34)(H,29,33)/t24-/m1/s1
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337102
PNG
(US9745291, Compound 148 | US9765068, Compound 148)
Show SMILES CC(=O)Nc1cncc(OCC(=O)NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C21H26N4O4/c1-15(26)24-18-8-20(11-22-9-18)29-14-21(28)23-10-19(27)13-25-7-6-16-4-2-3-5-17(16)12-25/h2-5,8-9,11,19,27H,6-7,10,12-14H2,1H3,(H,23,28)(H,24,26)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337093
PNG
(US9745291, Compound 139 | US9765068, Compound 139)
Show SMILES CS(=O)(=O)Nc1ncccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H26N4O5S/c1-30(27,28)23-20-18(7-4-9-21-20)29-14-19(26)22-11-17(25)13-24-10-8-15-5-2-3-6-16(15)12-24/h2-7,9,17,25H,8,10-14H2,1H3,(H,21,23)(H,22,26)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337087
PNG
(US9745291, Compound 133 | US9765068, Compound 133)
Show SMILES CN(C)c1cccnc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H28N4O3/c1-24(2)19-8-5-10-22-21(19)28-15-20(27)23-12-18(26)14-25-11-9-16-6-3-4-7-17(16)13-25/h3-8,10,18,26H,9,11-15H2,1-2H3,(H,23,27)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337098
PNG
(US9745291, Compound 144 | US9765068, Compound 144)
Show SMILES OC(CNC(=O)COc1cccc2cccnc12)CN1Cc2ccccc2C(F)(F)C1
Show InChI InChI=1S/C23H23F2N3O3/c24-23(25)15-28(12-17-5-1-2-8-19(17)23)13-18(29)11-27-21(30)14-31-20-9-3-6-16-7-4-10-26-22(16)20/h1-10,18,29H,11-15H2,(H,27,30)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337101
PNG
(US9745291, Compound 147 | US9765068, Compound 147)
Show SMILES CC(=O)Nc1ncccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N4O4/c1-15(26)24-21-19(7-4-9-22-21)29-14-20(28)23-11-18(27)13-25-10-8-16-5-2-3-6-17(16)12-25/h2-7,9,18,27H,8,10-14H2,1H3,(H,23,28)(H,22,24,26)
PDB

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Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337069
PNG
(US9745291, Compound 115 | US9765068, Compound 115)
Show SMILES OC(CNC(=O)COc1ccccc1-c1c[nH]cn1)CN1CCc2ccccc2C1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337017
PNG
(US9745291, Compound 63 | US9765068, Compound 63)
Show SMILES N[C@H](C(=O)NC[C@@H](O)CN1CCc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C20H25N3O2/c21-19(16-7-2-1-3-8-16)20(25)22-12-18(24)14-23-11-10-15-6-4-5-9-17(15)13-23/h1-9,18-19,24H,10-14,21H2,(H,22,25)/t18-,19+/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337011
PNG
(US9745291, Compound 57 | US9765068, Compound 57)
Show SMILES O[C@H](CNC(=O)Cc1ccccc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H24N2O2/c23-19(13-21-20(24)12-16-6-2-1-3-7-16)15-22-11-10-17-8-4-5-9-18(17)14-22/h1-9,19,23H,10-15H2,(H,21,24)/t19-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337005
PNG
(US9745291, Compound 51 | US9765068, Compound 51)
Show SMILES OC(CNC(=O)Cc1ccncc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C19H23N3O2/c23-18(12-21-19(24)11-15-5-8-20-9-6-15)14-22-10-7-16-3-1-2-4-17(16)13-22/h1-6,8-9,18,23H,7,10-14H2,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337012
PNG
(US9745291, Compound 58 | US9765068, Compound 58)
Show SMILES O[C@H](CNC(=O)CC1CCCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H30N2O2/c23-19(13-21-20(24)12-16-6-2-1-3-7-16)15-22-11-10-17-8-4-5-9-18(17)14-22/h4-5,8-9,16,19,23H,1-3,6-7,10-15H2,(H,21,24)/t19-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM336959
PNG
(US9745291, Compound 5 | US9765068, Compound 5)
Show SMILES CN(CC(O)CN1CCc2ccccc2C1)C(=O)COc1ccccc1
Show InChI InChI=1S/C21H26N2O3/c1-22(21(25)16-26-20-9-3-2-4-10-20)14-19(24)15-23-12-11-17-7-5-6-8-18(17)13-23/h2-10,19,24H,11-16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 3.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337080
PNG
(US9745291, Compound 126 | US9765068, Compound 126)
Show SMILES CC(Oc1ccccc1S(N)(=O)=O)C(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H27N3O5S/c1-15(29-19-8-4-5-9-20(19)30(22,27)28)21(26)23-12-18(25)14-24-11-10-16-6-2-3-7-17(16)13-24/h2-9,15,18,25H,10-14H2,1H3,(H,23,26)(H2,22,27,28)
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM337082
PNG
(US9745291, Compound 128 | US9765068, Compound 128)
Show SMILES CC(=O)Nc1cccnc1OCC(=O)NCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C21H26N4O4/c1-15(26)24-19-7-4-9-22-21(19)29-14-20(28)23-11-18(27)13-25-10-8-16-5-2-3-6-17(16)12-25/h2-7,9,18,27H,8,10-14H2,1H3,(H,23,28)(H,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a>5.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...


US Patent US9765068 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%