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Patent code US9771353

Compile Data Set for Download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342101
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)
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n/an/a 5n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342101
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)
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n/an/a 5n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342102
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C37H45N7O7/c1-37(2,3)32-24-33(44(4)43-32)41-36(45)40-30-11-12-31(29-10-8-7-9-28(29)30)51-34-13-14-38-35(42-34)39-25-21-26(47-6)23-27(22-25)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-24H,15-20H2,1-6H3,(H,38,39,42)(H2,40,41,45)
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TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342108
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...)
Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)
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n/an/a 5n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342107
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C39H44N8O6/c1-7-26-22-27(36(48)40-16-17-51-20-21-52-19-18-50-6)24-28(23-26)42-37-41-15-14-35(45-37)53-32-13-12-31(29-10-8-9-11-30(29)32)43-38(49)44-34-25-33(39(2,3)4)46-47(34)5/h1,8-15,22-25H,16-21H2,2-6H3,(H,40,48)(H,41,42,45)(H2,43,44,49)
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TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342110
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)n(C)n1
Show InChI InChI=1S/C37H39N9O4/c1-5-25-20-26(35(47)38-14-15-46-16-18-49-19-17-46)22-27(21-25)40-36-39-13-12-34(43-36)50-32-11-10-30(28-8-6-7-9-29(28)32)41-37(48)42-33-23-31(24(2)3)44-45(33)4/h1,6-13,20-24H,14-19H2,2-4H3,(H,38,47)(H,39,40,43)(H2,41,42,48)
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n/an/a 8n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342110
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)n(C)n1
Show InChI InChI=1S/C37H39N9O4/c1-5-25-20-26(35(47)38-14-15-46-16-18-49-19-17-46)22-27(21-25)40-36-39-13-12-34(43-36)50-32-11-10-30(28-8-6-7-9-29(28)32)41-37(48)42-33-23-31(24(2)3)44-45(33)4/h1,6-13,20-24H,14-19H2,2-4H3,(H,38,47)(H,39,40,43)(H2,41,42,48)
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n/an/a 9n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342111
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C38H42N8O6/c1-6-26-21-27(36(47)39-15-16-50-19-20-51-18-17-49-5)23-28(22-26)41-37-40-14-13-35(44-37)52-33-12-11-31(29-9-7-8-10-30(29)33)42-38(48)43-34-24-32(25(2)3)45-46(34)4/h1,7-14,21-25H,15-20H2,2-5H3,(H,39,47)(H,40,41,44)(H2,42,43,48)
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n/an/a 9n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342102
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C37H45N7O7/c1-37(2,3)32-24-33(44(4)43-32)41-36(45)40-30-11-12-31(29-10-8-7-9-28(29)30)51-34-13-14-38-35(42-34)39-25-21-26(47-6)23-27(22-25)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-24H,15-20H2,1-6H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 10n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342105
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C38H46N6O7/c1-38(2,3)34-25-36(44(4)43-34)42-37(45)41-32-11-12-33(31-10-8-7-9-30(31)32)51-27-13-14-39-35(24-27)40-26-21-28(47-6)23-29(22-26)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-25H,15-20H2,1-6H3,(H,39,40)(H2,41,42,45)
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TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342107
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C39H44N8O6/c1-7-26-22-27(36(48)40-16-17-51-20-21-52-19-18-50-6)24-28(23-26)42-37-41-15-14-35(45-37)53-32-13-12-31(29-10-8-9-11-30(29)32)43-38(49)44-34-25-33(39(2,3)4)46-47(34)5/h1,8-15,22-25H,16-21H2,2-6H3,(H,40,48)(H,41,42,45)(H2,43,44,49)
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TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342111
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C38H42N8O6/c1-6-26-21-27(36(47)39-15-16-50-19-20-51-18-17-49-5)23-28(22-26)41-37-40-14-13-35(44-37)52-33-12-11-31(29-9-7-8-10-30(29)33)42-38(48)43-34-24-32(25(2)3)45-46(34)4/h1,7-14,21-25H,15-20H2,2-5H3,(H,39,47)(H,40,41,44)(H2,42,43,48)
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TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342108
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...)
Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)
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TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342103
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C33H35N7O5S/c1-33(2,3)28-19-29(40(4)39-28)37-32(41)36-26-12-13-27(25-9-7-6-8-24(25)26)45-30-14-15-34-31(38-30)35-20-16-21(44-5)18-23(17-20)46(42,43)22-10-11-22/h6-9,12-19,22H,10-11H2,1-5H3,(H,34,35,38)(H2,36,37,41)
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n/an/a 36n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM342109
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C40H45N7O6/c1-7-27-22-28(38(48)42-16-17-51-20-21-52-19-18-50-6)24-29(23-27)43-36-25-30(14-15-41-36)53-34-13-12-33(31-10-8-9-11-32(31)34)44-39(49)45-37-26-35(40(2,3)4)46-47(37)5/h1,8-15,22-26H,16-21H2,2-6H3,(H,41,43)(H,42,48)(H2,44,45,49)
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n/an/a 53n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342109
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C40H45N7O6/c1-7-27-22-28(38(48)42-16-17-51-20-21-52-19-18-50-6)24-29(23-27)43-36-25-30(14-15-41-36)53-34-13-12-33(31-10-8-9-11-32(31)34)44-39(49)45-37-26-35(40(2,3)4)46-47(37)5/h1,8-15,22-26H,16-21H2,2-6H3,(H,41,43)(H,42,48)(H2,44,45,49)
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n/an/a 66n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342101
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)
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n/an/a 149n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 12


(Homo sapiens (Human))
BDBM342105
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C38H46N6O7/c1-38(2,3)34-25-36(44(4)43-34)42-37(45)41-32-11-12-33(31-10-8-7-9-30(31)32)51-27-13-14-39-35(24-27)40-26-21-28(47-6)23-29(22-26)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-25H,15-20H2,1-6H3,(H,39,40)(H2,41,42,45)
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n/an/a 160n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342101
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)
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n/an/a 499n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342102
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C37H45N7O7/c1-37(2,3)32-24-33(44(4)43-32)41-36(45)40-30-11-12-31(29-10-8-7-9-28(29)30)51-34-13-14-38-35(42-34)39-25-21-26(47-6)23-27(22-25)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-24H,15-20H2,1-6H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 543n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342110
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)n(C)n1
Show InChI InChI=1S/C37H39N9O4/c1-5-25-20-26(35(47)38-14-15-46-16-18-49-19-17-46)22-27(21-25)40-36-39-13-12-34(43-36)50-32-11-10-30(28-8-6-7-9-29(28)32)41-37(48)42-33-23-31(24(2)3)44-45(33)4/h1,6-13,20-24H,14-19H2,2-4H3,(H,38,47)(H,39,40,43)(H2,41,42,48)
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n/an/a 819n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342109
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C40H45N7O6/c1-7-27-22-28(38(48)42-16-17-51-20-21-52-19-18-50-6)24-29(23-27)43-36-25-30(14-15-41-36)53-34-13-12-33(31-10-8-9-11-32(31)34)44-39(49)45-37-26-35(40(2,3)4)46-47(37)5/h1,8-15,22-26H,16-21H2,2-6H3,(H,41,43)(H,42,48)(H2,44,45,49)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342111
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C38H42N8O6/c1-6-26-21-27(36(47)39-15-16-50-19-20-51-18-17-49-5)23-28(22-26)41-37-40-14-13-35(44-37)52-33-12-11-31(29-9-7-8-10-30(29)33)42-38(48)43-34-24-32(25(2)3)45-46(34)4/h1,7-14,21-25H,15-20H2,2-5H3,(H,39,47)(H,40,41,44)(H2,42,43,48)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342108
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...)
Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342107
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C39H44N8O6/c1-7-26-22-27(36(48)40-16-17-51-20-21-52-19-18-50-6)24-28(23-26)42-37-41-15-14-35(45-37)53-32-13-12-31(29-10-8-9-11-30(29)32)43-38(49)44-34-25-33(39(2,3)4)46-47(34)5/h1,8-15,22-25H,16-21H2,2-6H3,(H,40,48)(H,41,42,45)(H2,43,44,49)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM342105
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C38H46N6O7/c1-38(2,3)34-25-36(44(4)43-34)42-37(45)41-32-11-12-33(31-10-8-7-9-30(31)32)51-27-13-14-39-35(24-27)40-26-21-28(47-6)23-29(22-26)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-25H,15-20H2,1-6H3,(H,39,40)(H2,41,42,45)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342104
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C37H40N8O5/c1-7-24-20-25(34(46)38-16-17-49-19-18-48-6)22-26(21-24)40-35-39-15-14-33(43-35)50-30-13-12-29(27-10-8-9-11-28(27)30)41-36(47)42-32-23-31(37(2,3)4)44-45(32)5/h1,8-15,20-23H,16-19H2,2-6H3,(H,38,46)(H,39,40,43)(H2,41,42,47)
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n/an/a 1.01E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342106
PNG
(1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C45H61N7O11/c1-45(2,3)40-32-41(52(4)51-40)49-44(53)48-38-11-12-39(37-10-8-7-9-36(37)38)63-42-13-14-46-43(50-42)47-33-29-34(55-6)31-35(30-33)62-28-27-61-26-25-60-24-23-59-22-21-58-20-19-57-18-17-56-16-15-54-5/h7-14,29-32H,15-28H2,1-6H3,(H,46,47,50)(H2,48,49,53)
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n/an/a 1.23E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342107
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C39H44N8O6/c1-7-26-22-27(36(48)40-16-17-51-20-21-52-19-18-50-6)24-28(23-26)42-37-41-15-14-35(45-37)53-32-13-12-31(29-10-8-9-11-30(29)32)43-38(49)44-34-25-33(39(2,3)4)46-47(34)5/h1,8-15,22-25H,16-21H2,2-6H3,(H,40,48)(H,41,42,45)(H2,43,44,49)
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n/an/a 1.85E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342103
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C33H35N7O5S/c1-33(2,3)28-19-29(40(4)39-28)37-32(41)36-26-12-13-27(25-9-7-6-8-24(25)26)45-30-14-15-34-31(38-30)35-20-16-21(44-5)18-23(17-20)46(42,43)22-10-11-22/h6-9,12-19,22H,10-11H2,1-5H3,(H,34,35,38)(H2,36,37,41)
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n/an/a 1.94E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342108
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...)
Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)
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n/an/a 3.07E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342102
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C37H45N7O7/c1-37(2,3)32-24-33(44(4)43-32)41-36(45)40-30-11-12-31(29-10-8-7-9-28(29)30)51-34-13-14-38-35(42-34)39-25-21-26(47-6)23-27(22-25)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-24H,15-20H2,1-6H3,(H,38,39,42)(H2,40,41,45)
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n/an/a 5.23E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342105
PNG
(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C38H46N6O7/c1-38(2,3)34-25-36(44(4)43-34)42-37(45)41-32-11-12-33(31-10-8-7-9-30(31)32)51-27-13-14-39-35(24-27)40-26-21-28(47-6)23-29(22-26)50-20-19-49-18-17-48-16-15-46-5/h7-14,21-25H,15-20H2,1-6H3,(H,39,40)(H2,41,42,45)
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n/an/a 7.49E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342113
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-isopropyl-1H-pyrazo...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C(C)C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C41H48N8O6/c1-8-28-23-29(38(50)42-17-18-53-21-22-54-20-19-52-7)25-30(24-28)44-39-43-16-15-37(47-39)55-34-14-13-33(31-11-9-10-12-32(31)34)45-40(51)46-36-26-35(41(4,5)6)48-49(36)27(2)3/h1,9-16,23-27H,17-22H2,2-7H3,(H,42,50)(H,43,44,47)(H2,45,46,51)
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n/an/a 8.61E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342111
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C38H42N8O6/c1-6-26-21-27(36(47)39-15-16-50-19-20-51-18-17-49-5)23-28(22-26)41-37-40-14-13-35(44-37)52-33-12-11-31(29-9-7-8-10-30(29)33)42-38(48)43-34-24-32(25(2)3)45-46(34)4/h1,7-14,21-25H,15-20H2,2-5H3,(H,39,47)(H,40,41,44)(H2,42,43,48)
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n/an/a 9.52E+3n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342109
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C40H45N7O6/c1-7-27-22-28(38(48)42-16-17-51-20-21-52-19-18-50-6)24-29(23-27)43-36-25-30(14-15-41-36)53-34-13-12-33(31-10-8-9-11-32(31)34)44-39(49)45-37-26-35(40(2,3)4)46-47(37)5/h1,8-15,22-26H,16-21H2,2-6H3,(H,41,43)(H,42,48)(H2,44,45,49)
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n/an/a 1.24E+4n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342112
PNG
(3-((4-((4-(3-(1,3-Di-tert-butyl-1H-pyrazol-5-yl)ur...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C(C)(C)C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C42H50N8O6/c1-9-28-24-29(38(51)43-18-19-54-22-23-55-21-20-53-8)26-30(25-28)45-39-44-17-16-37(48-39)56-34-15-14-33(31-12-10-11-13-32(31)34)46-40(52)47-36-27-35(41(2,3)4)49-50(36)42(5,6)7/h1,10-17,24-27H,18-23H2,2-8H3,(H,43,51)(H,44,45,48)(H2,46,47,52)
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n/an/a 1.31E+4n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342114
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-propyl-1H-pyrazol-5...)
Show SMILES CCCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C41H48N8O6/c1-7-18-49-36(27-35(48-49)41(3,4)5)46-40(51)45-33-13-14-34(32-12-10-9-11-31(32)33)55-37-15-16-43-39(47-37)44-30-25-28(8-2)24-29(26-30)38(50)42-17-19-53-22-23-54-21-20-52-6/h2,9-16,24-27H,7,17-23H2,1,3-6H3,(H,42,50)(H,43,44,47)(H2,45,46,51)
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n/an/a 1.31E+4n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM342110
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(cc(c4)C(=O)NCCN4CCOCC4)C#C)n3)c3ccccc23)n(C)n1
Show InChI InChI=1S/C37H39N9O4/c1-5-25-20-26(35(47)38-14-15-46-16-18-49-19-17-46)22-27(21-25)40-36-39-13-12-34(43-36)50-32-11-10-30(28-8-6-7-9-29(28)32)41-37(48)42-33-23-31(24(2)3)44-45(33)4/h1,6-13,20-24H,14-19H2,2-4H3,(H,38,47)(H,39,40,43)(H2,41,42,48)
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n/an/a 1.41E+4n/an/an/an/an/an/a



TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9771353 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%