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Patent code US9771369

Compile Data Set for Download or QSAR

Found 502 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342222
PNG
(4-[4-[5-(4-methoxy-3-methyl-phenyl)-4- methyl-1H-i...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(C)c1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342225
PNG
(6-(4-fluorophenyl)-4-[4-[5-(4- fluorophenyl)-4-met...)
Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342225
PNG
(6-(4-fluorophenyl)-4-[4-[5-(4- fluorophenyl)-4-met...)
Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342231
PNG
(4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol-2-...)
Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(C)cc12
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342235
PNG
(4-[4-[5-(4-ethoxy-3-methyl-phenyl)-4- methyl-1H-im...)
Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342237
PNG
(4-[4-[4-[5-(1,3-benzodioxol-5-yl)-4- methyl-1H-imi...)
Show SMILES Cc1nc([nH]c1-c1ccc2OCOc2c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342241
PNG
(6-(1,3-dimethylpyrazol-4-yl)-4-[4-(4- methyl-5-phe...)
Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342241
PNG
(6-(1,3-dimethylpyrazol-4-yl)-4-[4-(4- methyl-5-phe...)
Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342244
PNG
(4-[4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1...)
Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(c1)N1CCOCC1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342253
PNG
(6-(4-fluorophenyl)-4-[4-[4-methyl-5-[4- (trifluoro...)
Show SMILES Cc1nc([nH]c1-c1ccc(OC(F)(F)F)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342263
PNG
(4-[4-[4-[5-(3-ethoxy-4-methyl-phenyl)- 4-methyl-1H...)
Show SMILES CCOc1cc(ccc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342264
PNG
(4-[4-[5-(3-ethoxy-4-methyl-phenyl)-4- methyl-1H-im...)
Show SMILES CCOc1cc(ccc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342274
PNG
(4-[4-[4-[5-(3-methoxy-4-methyl- phenyl)-4-methyl-1...)
Show SMILES COc1cc(ccc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342282
PNG
(6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- [5-(3-met...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342292
PNG
(4-[4-[4-[5-(3-methoxyphenyl)-4- (trifluoromethyl)-...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C(F)(F)F)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342299
PNG
(4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol-2-...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(C)cc12
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342300
PNG
(4-[4-[4-[5-(2,3-dihydro-1,4- benzodioxin-6-yl)-4-m...)
Show SMILES Cc1nc([nH]c1-c1ccc2OCCOc2c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342304
PNG
(6-(4-fluorophenyl)-4-[4-[4-methyl-5-[4- (trifluoro...)
Show SMILES Cc1nc([nH]c1-c1ccc(cc1)C(F)(F)F)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342321
PNG
(6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- [5-(4-met...)
Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342326
PNG
(4-[4-[5-(1,3-benzodioxol-5-yl)-4- methyl-1H-imidaz...)
Show SMILES COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc2OCOc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342328
PNG
(4-[4-[4-[5-(4-ethoxy-3-methyl-phenyl)- 4-methyl-1H...)
Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342333
PNG
(6-methyl-4-[4-methyl-4-[4-methyl-5-[4- (trifluorom...)
Show SMILES Cc1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccc(cc1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342342
PNG
(4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...)
Show SMILES Cc1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(Cl)cc1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342343
PNG
(4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...)
Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342344
PNG
(4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...)
Show SMILES COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(Cl)cc1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342346
PNG
(6-(6-methoxy-3-pyridyl)-4-[4-methyl-4- [4-methyl-5...)
Show SMILES COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(cc1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342349
PNG
(4-[4-[4-[5-(5-fluoro-6-methoxy-3- pyridyl)-4-methy...)
Show SMILES COc1ncc(cc1F)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342355
PNG
(6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- [5-(3-flu...)
Show SMILES COc1ccc(cc1F)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342356
PNG
(4-[4-[5-(3-fluoro-4-methoxy-phenyl)-4- methyl-1H-i...)
Show SMILES COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(F)c1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342359
PNG
(4-[4-[5-[3-(difluoromethoxy)phenyl]-4- methyl-1H-i...)
Show SMILES Cc1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1cccc(OC(F)F)c1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342384
PNG
(2-[4-[4-[4-[5-(3-methoxyphenyl)-4- methyl-1H-imida...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(OCC(O)=O)cc1
PDB

GoogleScholar
AffyNet 
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342387
PNG
(2-[4-[4-[4-[5-(4-ethoxyphenyl)-4- methyl-1H-imidaz...)
Show SMILES CCOc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(OCC(O)=O)cc1
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342394
PNG
(4-[4-[4-[5-[3-(difluoromethoxy)phenyl]- 4-methyl-1...)
Show SMILES Cc1nc([nH]c1-c1cccc(OC(F)F)c1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C(N)=O
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342398
PNG
(5-[4-[4-[5-[4-(difluoromethyl)phenyl]-4- methyl-1H...)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(cc1)C(F)F
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342411
PNG
(4-[5-[4-[4-[5-[4- (difluoromethoxy)phenyl]-4-methy...)
Show SMILES Cc1nc([nH]c1-c1ccc(OC(F)F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(nc1)N1CCOCC1
PDB

UniProtKB/SwissProt

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342413
PNG
(5-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...)
Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(nc1)C#N
PDB

UniProtKB/SwissProt

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342416
PNG
(4-[4-[4-[5-[4-(difluoromethoxy)phenyl]- 4-methyl-1...)
Show SMILES Cc1nc([nH]c1-c1ccc(OC(F)F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C(N)=O
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342419
PNG
(5-[4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(nc1)C#N
PDB

UniProtKB/SwissProt

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342152
PNG
(4-[4-(5-methyl-4-phenyl-1H-imidazol-2- yl)-1-piper...)
Show SMILES Cc1[nH]c(nc1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccncc1
PDB

UniProtKB/SwissProt

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342154
PNG
(6-(2-methoxy-4-pyridyl)-4-[4-(4- methyl-5-phenyl-1...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1
PDB

UniProtKB/SwissProt

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342154
PNG
(6-(2-methoxy-4-pyridyl)-4-[4-(4- methyl-5-phenyl-1...)
Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342165
PNG
(4-[4-[5-[3-(difluoromethoxy)phenyl]- 4H-1,2,4-tria...)
Show SMILES FC(F)Oc1cccc(c1)-c1nnc([nH]1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342181
PNG
(4-[4-[4-[5-(4-fluorophenyl)-4-methyl- 1H-imidazol-...)
Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342182
PNG
(4-[4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342183
PNG
(4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol-2-...)
Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342192
PNG
(4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...)
Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

UniProtKB/SwissProt

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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342201
PNG
(4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...)
Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

UniProtKB/SwissProt

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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342201
PNG
(4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...)
Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM342204
PNG
(4-[4-[4-[5-(4-chlorophenyl)-4-methyl- 1H-imidazol-...)
Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
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US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM342216
PNG
(4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...)
Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)S(N)(=O)=O
PDB

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500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US9771369 (2017)

More data for this
Ligand-Target Pair
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