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Patent code US9771376

Compile Data Set for Download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145281
PNG
(US8952169, 60 | US9771376, Example 60)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-21(25)18-7-17(16-2-3-16)20(8-19(18)23)28-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,24,25)
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n/an/a 0.300n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145285
PNG
(US8952169, 64 | US9771376, Example 64)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)
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n/an/a 0.400n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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n/an/a 1.31n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145369
PNG
(US8952169, 148 | US9771376, Example 148)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H30FNO4S/c25-21-9-22(30-13-24-10-14-5-15(11-24)7-16(6-14)12-24)19(17-1-2-17)8-20(21)23(27)26-31(28,29)18-3-4-18/h8-9,14-18H,1-7,10-13H2,(H,26,27)
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n/an/a 1.40n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342473
PNG
(Cyclopropanesulfonic acid 4-(bicyclo[4.1.0]hept-1-...)
Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H26FNO4S/c22-18-10-19(27-12-21-8-2-1-3-14(21)11-21)16(13-4-5-13)9-17(18)20(24)23-28(25,26)15-6-7-15/h9-10,13-15H,1-8,11-12H2,(H,23,24)
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n/an/a 2n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145284
PNG
(US8952169, 63 | US9771376, Example 63)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H29FN2O4S/c1-24-30(27,28)25-21(26)18-7-17(16-2-3-16)20(8-19(18)23)29-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16,24H,2-6,9-12H2,1H3,(H,25,26)
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 3.60n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145229
PNG
(US8952169, 8 | US9771376, Example 8)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)CC2
Show InChI InChI=1S/C18H23ClFNO4S/c1-18(2)11-5-4-10(13(18)6-11)9-25-16-8-15(20)12(7-14(16)19)17(22)21-26(3,23)24/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,21,22)/t10-,11+,13+/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145387
PNG
(US8952169, 166 | US9771376, Example 166)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-8-13(12-2-3-12)16(9-15(14)19)26-10-11-4-6-18(20,21)7-5-11/h8-9,11-12H,2-7,10H2,1H3,(H,22,23)
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n/an/a 4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145371
PNG
(US8952169, 150 | US9771376, Example 150)
Show SMILES FC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H30F2N2O4S/c25-18-11-28(12-18)33(30,31)27-23(29)20-6-19(17-1-2-17)22(7-21(20)26)32-13-24-8-14-3-15(9-24)5-16(4-14)10-24/h6-7,14-18H,1-5,8-13H2,(H,27,29)
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n/an/a 4.30n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145230
PNG
(US8952169, 9 | US9771376, Example 9)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C18H21ClFNO4S/c1-26(23,24)21-18(22)13-7-14(19)16(8-15(13)20)25-17-11-3-9-2-10(5-11)6-12(17)4-9/h7-12,17H,2-6H2,1H3,(H,21,22)
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n/an/a 5.20n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145227
PNG
(US8952169, 6 | US9771376, Example 6)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)
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n/an/a 5.5n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145391
PNG
(US8952169, 170 | US8952169, 251 | US9771376, Examp...)
Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H29F3N2O4S/c25-20-9-21(33-13-23-10-14-6-16(11-23)24(26,27)17(7-14)12-23)18(15-2-3-15)8-19(20)22(30)28-34(31,32)29-4-1-5-29/h8-9,14-17H,1-7,10-13H2,(H,28,30)
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n/an/a 6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145368
PNG
(US8952169, 147 | US9771376, Example 147)
Show SMILES O[C@H]1CCN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H33FN2O5S/c26-22-9-23(33-14-25-10-15-5-16(11-25)7-17(6-15)12-25)20(18-1-2-18)8-21(22)24(30)27-34(31,32)28-4-3-19(29)13-28/h8-9,15-19,29H,1-7,10-14H2,(H,27,30)/t15?,16?,17?,19-,25?/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145233
PNG
(US8952169, 12 | US9771376, Example 13)
Show SMILES CC1(C)C2CCC1(C)C(C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)
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n/an/a 6.90n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145318
PNG
(US8952169, 97 | US9771376, Example 97)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25)
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n/an/a 7.30n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145257
PNG
(US8952169, 36 | US9771376, Example 36)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC2CCCCC2)cc1F
Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-9-13(17)15(10-14(12)18)23-8-7-11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)
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n/an/a 7.70n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145231
PNG
(US8952169, 10 | US9771376, Example 10)
Show SMILES C[C@@H]1[C@H]2C[C@@H](C[C@H]1Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C2(C)C
Show InChI InChI=1S/C18H23ClFNO4S/c1-9-12-5-10(18(12,2)3)6-15(9)25-16-8-14(20)11(7-13(16)19)17(22)21-26(4,23)24/h7-10,12,15H,5-6H2,1-4H3,(H,21,22)/t9-,10+,12-,15-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145232
PNG
(US8952169, 11 | US9771376, Example 11)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C20H25ClFNO4S/c1-28(25,26)23-19(24)15-7-16(21)18(8-17(15)22)27-3-2-20-9-12-4-13(10-20)6-14(5-12)11-20/h7-8,12-14H,2-6,9-11H2,1H3,(H,23,24)
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n/an/a 8.70n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145389
PNG
(US8952169, 168 | US9771376, Example 168)
Show SMILES OCCCNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H33FN2O5S/c25-21-10-22(32-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(29)27-33(30,31)26-4-1-5-28/h9-10,15-18,26,28H,1-8,11-14H2,(H,27,29)
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n/an/a 9.20n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
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n/an/a 9.90n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145373
PNG
(US8952169, 152 | US9771376, Example 152)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C19H21ClF3NO4S/c1-29(26,27)24-17(25)13-4-14(20)16(5-15(13)21)28-9-18-6-10-2-11(7-18)19(22,23)12(3-10)8-18/h4-5,10-12H,2-3,6-9H2,1H3,(H,24,25)
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n/an/a 10.6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145261
PNG
(US8952169, 40 | US9771376, Example 41)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(O[C@H]2C3CC4CC2CC(Cl)(C4)C3)cc1F
Show InChI InChI=1S/C18H20Cl2FNO4S/c1-27(24,25)22-17(23)12-4-13(19)15(5-14(12)21)26-16-10-2-9-3-11(16)8-18(20,6-9)7-10/h4-5,9-11,16H,2-3,6-8H2,1H3,(H,22,23)/t9?,10?,11?,16-,18?
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145261
PNG
(US8952169, 40 | US9771376, Example 41)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(O[C@H]2C3CC4CC2CC(Cl)(C4)C3)cc1F
Show InChI InChI=1S/C18H20Cl2FNO4S/c1-27(24,25)22-17(23)12-4-13(19)15(5-14(12)21)26-16-10-2-9-3-11(16)8-18(20,6-9)7-10/h4-5,9-11,16H,2-3,6-8H2,1H3,(H,22,23)/t9?,10?,11?,16-,18?
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145243
PNG
(US8952169, 22 | US9771376, Example 22)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3CCCCc3c2)cc1F
Show InChI InChI=1S/C18H17ClFNO4S/c1-26(23,24)21-18(22)14-9-15(19)17(10-16(14)20)25-13-7-6-11-4-2-3-5-12(11)8-13/h6-10H,2-5H2,1H3,(H,21,22)
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n/an/a 13.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145367
PNG
(US8952169, 146 | US9771376, Example 146)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C21H25ClFNO4S/c22-17-6-16(20(25)24-29(26,27)15-1-2-15)18(23)7-19(17)28-11-21-8-12-3-13(9-21)5-14(4-12)10-21/h6-7,12-15H,1-5,8-11H2,(H,24,25)
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n/an/a 15.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145293
PNG
(US8952169, 72 | US9771376, Example 72)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C21H27ClFNO5S/c1-28-2-3-30(26,27)24-20(25)16-7-17(22)19(8-18(16)23)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,2-6,9-12H2,1H3,(H,24,25)
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n/an/a 15.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145278
PNG
(US8952169, 57 | US9771376, Example 57)
Show SMILES CC1(C)CCc2cc(OCc3cc(F)c(cc3Cl)C(=O)NS(=O)(=O)N3CCC3)ccc2O1
Show InChI InChI=1S/C22H24ClFN2O5S/c1-22(2)7-6-14-10-16(4-5-20(14)31-22)30-13-15-11-19(24)17(12-18(15)23)21(27)25-32(28,29)26-8-3-9-26/h4-5,10-12H,3,6-9,13H2,1-2H3,(H,25,27)
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n/an/a 15.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145226
PNG
(US8952169, 5 | US9771376, Example 5)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H23F2NO4S/c1-27(24,25)22-18(23)14-5-16(21)17(6-15(14)20)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)
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n/an/a 20.1n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145244
PNG
(US8952169, 23 | US9771376, Example 23)
Show SMILES CC12CC3CC(C)(C1)CC(COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)(C3)C2
Show InChI InChI=1S/C21H27ClFNO4S/c1-19-6-13-7-20(2,9-19)11-21(8-13,10-19)12-28-17-5-16(23)14(4-15(17)22)18(25)24-29(3,26)27/h4-5,13H,6-12H2,1-3H3,(H,24,25)
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n/an/a 22.9n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145390
PNG
(US8952169, 169 | US9771376, Example 169)
Show SMILES COC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H33FN2O5S/c1-32-19-12-28(13-19)34(30,31)27-24(29)21-7-20(18-2-3-18)23(8-22(21)26)33-14-25-9-15-4-16(10-25)6-17(5-15)11-25/h7-8,15-19H,2-6,9-14H2,1H3,(H,27,29)
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n/an/a 25n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342437
PNG
(5-chloro-2-fluoro-N-(methyl- sulfonyl)-4-(((1R,2S,...)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)N[C](C)(=O)=O
Show InChI InChI=1S/C19H23ClFNO4/c1-17(2)10-5-6-18(17,3)15(7-10)26-14-9-13(21)11(8-12(14)20)16(23)22-19(4,24)25/h8-10,15H,5-7H2,1-4H3,(H,22,23,24,25)/t10-,15+,18+/m1/s1
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n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145247
PNG
(US8952169, 26 | US9771376, Example 26)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-19(25)15-6-16(21)18(7-17(15)22)28-11-20-8-12-3-13(9-20)5-14(4-12)10-20/h6-7,12-14H,3-5,8-11H2,1-2H3,(H,23,25)
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n/an/a 28.1n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145347
PNG
(US8952169, 126 | US8952169, 128 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H16ClF4NO4S/c1-26(23,24)21-14(22)10-6-11(16)13(7-12(10)17)25-9-4-2-8(3-5-9)15(18,19)20/h6-9H,2-5H2,1H3,(H,21,22)
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n/an/a 30.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145356
PNG
(US8952169, 135 | US9771376, Example 135)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC2CC3CC2C2CCCC32)cc1F
Show InChI InChI=1S/C19H24ClFN2O4S/c1-23(2)28(25,26)22-19(24)14-8-15(20)18(9-16(14)21)27-17-7-10-6-13(17)12-5-3-4-11(10)12/h8-13,17H,3-7H2,1-2H3,(H,22,24)
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n/an/a 30.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145237
PNG
(US8952169, 16 | US9771376, Example 16)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-17(24)13-3-14(20)16(4-15(13)21)27-10-18-5-11-2-12(6-18)8-19(22,7-11)9-18/h3-4,11-12H,2,5-10H2,1H3,(H,23,24)
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n/an/a 31.2n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145290
PNG
(US8952169, 69 | US9771376, Example 69)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H24ClFN2O4S/c1-22-28(25,26)23-18(24)14-5-15(20)17(6-16(14)21)27-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13,22H,2-4,7-10H2,1H3,(H,23,24)
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n/an/a 34.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145291
PNG
(US8952169, 70 | US9771376, Example 70)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C21H26ClFN2O4S/c22-17-7-16(20(26)24-30(27,28)25-2-1-3-25)18(23)8-19(17)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,1-6,9-12H2,(H,24,26)
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n/an/a 36.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145235
PNG
(US8952169, 14 | US9771376, Example 14)
Show SMILES C[C@H]1[C@@H]2C[C@H](C[C@@H]1Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C2(C)C
Show InChI InChI=1S/C18H23ClFNO4S/c1-9-12-5-10(18(12,2)3)6-15(9)25-16-8-14(20)11(7-13(16)19)17(22)21-26(4,23)24/h7-10,12,15H,5-6H2,1-4H3,(H,21,22)/t9-,10+,12-,15-/m0/s1
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n/an/a 37.7n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145240
PNG
(US8952169, 19 | US9771376, Example 19)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1
Show InChI InChI=1S/C19H24ClNO4S/c1-26(23,24)21-18(22)15-2-3-17(16(20)7-15)25-11-19-8-12-4-13(9-19)6-14(5-12)10-19/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,22)
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n/an/a 38.6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145303
PNG
(US8952169, 82 | US9771376, Example 82)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CCC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H17ClF4N2O4S/c1-22(2)27(24,25)21-13(23)9-6-10(16)12(7-11(9)17)26-8-14(4-3-5-14)15(18,19)20/h6-7H,3-5,8H2,1-2H3,(H,21,23)
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n/an/a 41.6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145241
PNG
(US8952169, 20 | US9771376, Example 20)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCCC23CC4CC(CC(C4)C2)C3)c(Cl)c1
Show InChI InChI=1S/C20H26ClNO4S/c1-27(24,25)22-19(23)16-2-3-18(17(21)9-16)26-5-4-20-10-13-6-14(11-20)8-15(7-13)12-20/h2-3,9,13-15H,4-8,10-12H2,1H3,(H,22,23)
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n/an/a 56.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145255
PNG
(US8952169, 34 | US9771376, Example 34)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F
Show InChI InChI=1S/C19H26ClFN2O4S/c1-19(2)12-6-5-11(14(19)7-12)10-27-17-9-16(21)13(8-15(17)20)18(24)22-28(25,26)23(3)4/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,22,24)/t11-,12+,14+/m1/s1
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n/an/a 65.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145327
PNG
(US8952169, 106 | US9771376, Example 106)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@@H](CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H18ClF4NO4S/c1-27(24,25)22-15(23)11-6-12(17)14(7-13(11)18)26-8-9-2-4-10(5-3-9)16(19,20)21/h6-7,9-10H,2-5,8H2,1H3,(H,22,23)/t9-,10-
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n/an/a 84.7n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342455
PNG
(Synthesis of 5-chloro-N-(N,N-dimethylsulfamoyl)-2-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC5(C[C](Cl)(C5)(C4)C2)C3)cc1F
Show InChI InChI=1S/C21H26Cl2FN2O4S/c1-26(2)31(28,29)25-18(27)14-3-15(22)17(4-16(14)24)30-12-20-6-13-5-19(8-20)9-21(23,7-13,10-19)11-20/h3-4,13H,5-12H2,1-2H3,(H,25,27)
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n/an/a 85.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145254
PNG
(US8952169, 33 | US9771376, Example 33)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C19H24ClFN2O4S/c1-23(2)28(25,26)22-19(24)14-8-15(20)17(9-16(14)21)27-18-12-4-10-3-11(6-12)7-13(18)5-10/h8-13,18H,3-7H2,1-2H3,(H,22,24)
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n/an/a 93.7n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342434
PNG
(Synthesis of 5-chloro-4-(cyclohexylmethoxy)-2-fluo...)
Show SMILES CS(=O)(=O)NC(=O)c1cnc(OCC23CC4CC5(CC(C5)(C4)C2)C3)c(Cl)c1
Show InChI InChI=1S/C19H23ClN2O4S/c1-27(24,25)22-15(23)13-2-14(20)16(21-6-13)26-11-19-5-12-3-17(9-19)7-18(4-12,8-17)10-19/h2,6,12H,3-5,7-11H2,1H3,(H,22,23)
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n/an/a 106n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145233
PNG
(US8952169, 12 | US9771376, Example 13)
Show SMILES CC1(C)C2CCC1(C)C(C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)
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n/an/a 123n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145252
PNG
(US8952169, 31 | US9771376, Example 31)
Show SMILES CC(Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H25ClFNO4S/c1-11(20-8-12-3-13(9-20)5-14(4-12)10-20)27-18-7-17(22)15(6-16(18)21)19(24)23-28(2,25)26/h6-7,11-14H,3-5,8-10H2,1-2H3,(H,23,24)
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n/an/a 146n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145236
PNG
(US8952169, 15 | US9771376, Example 15)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC2CC2)cc1F
Show InChI InChI=1S/C13H15ClFNO4S/c1-21(18,19)16-13(17)9-6-10(14)12(7-11(9)15)20-5-4-8-2-3-8/h6-8H,2-5H2,1H3,(H,16,17)
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n/an/a 170n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145239
PNG
(US8952169, 18 | US9771376, Example 18)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(NCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H24ClFN2O3S/c1-27(25,26)23-18(24)14-5-15(20)17(6-16(14)21)22-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13,22H,2-4,7-10H2,1H3,(H,23,24)
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n/an/a 356n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145247
PNG
(US8952169, 26 | US9771376, Example 26)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-19(25)15-6-16(21)18(7-17(15)22)28-11-20-8-12-3-13(9-20)5-14(4-12)10-20/h6-7,12-14H,3-5,8-11H2,1-2H3,(H,23,25)
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n/an/a 772n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145229
PNG
(US8952169, 8 | US9771376, Example 8)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)CC2
Show InChI InChI=1S/C18H23ClFNO4S/c1-18(2)11-5-4-10(13(18)6-11)9-25-16-8-15(20)12(7-14(16)19)17(22)21-26(3,23)24/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,21,22)/t10-,11+,13+/m1/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145227
PNG
(US8952169, 6 | US9771376, Example 6)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)
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n/an/a 1.91E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145249
PNG
(US8952169, 28 | US9771376, Example 28)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(O)(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H23ClFNO5S/c1-28(25,26)22-17(23)13-3-14(20)16(4-15(13)21)27-10-18-5-11-2-12(6-18)8-19(24,7-11)9-18/h3-4,11-12,24H,2,5-10H2,1H3,(H,22,23)
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n/an/a 2.25E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145248
PNG
(US8952169, 27 | US9771376, Example 27)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(cc1F)C(=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C19H22ClFN2O4S/c1-28(26,27)23-18(25)14-5-15(20)13(6-16(14)21)17(24)22-19-7-10-2-11(8-19)4-12(3-10)9-19/h5-6,10-12H,2-4,7-9H2,1H3,(H,22,24)(H,23,25)
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n/an/a 1.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%