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Patent code US9775839

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339977
PNG
(5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-(5-chloro-1...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H21ClN6O/c20-11-5-6-13-10(7-11)8-15(24-13)17-18(19(22)27)23-9-16(26-17)25-14-4-2-1-3-12(14)21/h5-9,12,14,24H,1-4,21H2,(H2,22,27)(H,25,26)/t12-,14+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340000
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES CCc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C20H24N6O2/c1-2-11-3-4-14-12(7-11)8-16(24-14)18-19(20(22)27)23-9-17(26-18)25-15-5-6-28-10-13(15)21/h3-4,7-9,13,15,24H,2,5-6,10,21H2,1H3,(H2,22,27)(H,25,26)/t13-,15+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340008
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(pyridin-3-yl)-1...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cccnc1
Show InChI InChI=1S/C21H21N7O/c1-12(22)9-25-18-11-26-20(21(23)29)19(28-18)17-8-15-7-13(4-5-16(15)27-17)14-3-2-6-24-10-14/h2-8,10-12,27H,9,22H2,1H3,(H2,23,29)(H,25,28)/t12-/m0/s1
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339978
PNG
(5-{[(2S)-2- aminopropyl]amino}-3-(4- bromo-1H-indo...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(Br)cccc2[nH]1
Show InChI InChI=1/C16H17BrN6O/c1-8(18)6-20-13-7-21-15(16(19)24)14(23-13)12-5-9-10(17)3-2-4-11(9)22-12/h2-5,7-8,22H,6,18H2,1H3,(H2,19,24)(H,20,23)/t8-/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50075732
PNG
(CHEMBL3414584 | US9775839, 2.1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C19H22N6O/c20-12-6-2-4-8-14(12)24-16-10-22-18(19(21)26)17(25-16)15-9-11-5-1-3-7-13(11)23-15/h1,3,5,7,9-10,12,14,23H,2,4,6,8,20H2,(H2,21,26)(H,24,25)/t12-,14+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339999
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES COc1ccc2[nH]c(cc2c1OC)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C20H24N6O4/c1-28-15-4-3-12-10(19(15)29-2)7-14(24-12)17-18(20(22)27)23-8-16(26-17)25-13-5-6-30-9-11(13)21/h3-4,7-8,11,13,24H,5-6,9,21H2,1-2H3,(H2,22,27)(H,25,26)/t11-,13+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339979
PNG
(5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- ...)
Show SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1/C18H19ClN6O2/c19-10-2-1-3-12-9(10)6-14(23-12)16-17(18(21)26)22-7-15(25-16)24-13-4-5-27-8-11(13)20/h1-3,6-7,11,13,23H,4-5,8,20H2,(H2,21,26)(H,24,25)
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339998
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2c3OCCOc3ccc2[nH]1
Show InChI InChI=1/C20H22N6O4/c21-11-9-28-4-3-13(11)25-16-8-23-18(20(22)27)17(26-16)14-7-10-12(24-14)1-2-15-19(10)30-6-5-29-15/h1-2,7-8,11,13,24H,3-6,9,21H2,(H2,22,27)(H,25,26)/t11-,13+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339975
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(1-methyl-1H-pyr...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cnn(C)c1
Show InChI InChI=1S/C20H22N8O/c1-11(21)7-23-17-9-24-19(20(22)29)18(27-17)16-6-13-5-12(3-4-15(13)26-16)14-8-25-28(2)10-14/h3-6,8-11,26H,7,21H2,1-2H3,(H2,22,29)(H,23,27)/t11-/m0/s1
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339981
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C19H22N6O3/c1-27-11-2-3-13-10(6-11)7-15(23-13)17-18(19(21)26)22-8-16(25-17)24-14-4-5-28-9-12(14)20/h2-3,6-8,12,14,23H,4-5,9,20H2,1H3,(H2,21,26)(H,24,25)/t12-,14+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50075733
PNG
(CHEMBL3415610 | US9775839, 8.5)
Show SMILES COc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C19H22N6O3/c1-27-15-4-2-3-12-10(15)7-14(23-12)17-18(19(21)26)22-8-16(25-17)24-13-5-6-28-9-11(13)20/h2-4,7-8,11,13,23H,5-6,9,20H2,1H3,(H2,21,26)(H,24,25)/t11-,13+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339997
PNG
(5-(((3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)C(F)(F)F
Show InChI InChI=1/C19H19F3N6O3S/c20-19(21,22)10-1-2-12-9(5-10)6-13(26-12)16-17(18(24)29)25-7-15(28-16)27-14-8-32(30,31)4-3-11(14)23/h1-2,5-7,11,14,26H,3-4,8,23H2,(H2,24,29)(H,27,28)/t11-,14+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339974
PNG
((S)-5-((2-aminopropyl)amino)-3-(5-bromo-1H-indol-2...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C16H17BrN6O/c1-8(18)6-20-13-7-21-15(16(19)24)14(23-13)12-5-9-4-10(17)2-3-11(9)22-12/h2-5,7-8,22H,6,18H2,1H3,(H2,19,24)(H,20,23)/t8-/m0/s1
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339984
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C19H22N6O4S/c1-29-11-2-3-13-10(6-11)7-14(23-13)17-18(19(21)26)22-8-16(25-17)24-15-9-30(27,28)5-4-12(15)20/h2-3,6-8,12,15,23H,4-5,9,20H2,1H3,(H2,21,26)(H,24,25)/t12-,15+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339994
PNG
(5-{[(2R)-2-amino-3- methoxypropyl]amino}-3- (4-met...)
Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(OC)cccc2[nH]1
Show InChI InChI=1/C18H22N6O3/c1-26-9-10(19)7-21-15-8-22-17(18(20)25)16(24-15)13-6-11-12(23-13)4-3-5-14(11)27-2/h3-6,8,10,23H,7,9,19H2,1-2H3,(H2,20,25)(H,21,24)/t10-/s2
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339986
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C18H19ClN6O3S/c19-10-1-2-12-9(5-10)6-13(23-12)16-17(18(21)26)22-7-15(25-16)24-14-8-29(27,28)4-3-11(14)20/h1-2,5-7,11,14,23H,3-4,8,20H2,(H2,21,26)(H,24,25)/t11-,14+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339982
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccc(F)cc2[nH]1
Show InChI InChI=1/C18H19FN6O2/c19-10-2-1-9-5-14(23-13(9)6-10)16-17(18(21)26)22-7-15(25-16)24-12-3-4-27-8-11(12)20/h1-2,5-7,11-12,23H,3-4,8,20H2,(H2,21,26)(H,24,25)/t11-,12+/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339983
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1/C18H19ClN6O3S/c19-10-2-1-3-12-9(10)6-13(23-12)16-17(18(21)26)22-7-15(25-16)24-14-8-29(27,28)5-4-11(14)20/h1-3,6-7,11,14,23H,4-5,8,20H2,(H2,21,26)(H,24,25)/t11-,14+/s2
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339993
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C18H20N6O2/c19-11-9-26-6-5-13(11)23-15-8-21-17(18(20)25)16(24-15)14-7-10-3-1-2-4-12(10)22-14/h1-4,7-8,11,13,22H,5-6,9,19H2,(H2,20,25)(H,23,24)/t11-,13+/s2
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339989
PNG
(5-{[(1R,2S)-2- aminocyclohexyl]amino}- 3-(4-methyl...)
Show SMILES Cc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCCC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C20H24N6O/c1-11-5-4-8-14-12(11)9-16(24-14)18-19(20(22)27)23-10-17(26-18)25-15-7-3-2-6-13(15)21/h4-5,8-10,13,15,24H,2-3,6-7,21H2,1H3,(H2,22,27)(H,25,26)/t13-,15+/s2
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340003
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ncccc2[nH]1
Show InChI InChI=1/C17H19N7O2/c18-9-8-26-5-3-10(9)23-14-7-21-16(17(19)25)15(24-14)13-6-12-11(22-13)2-1-4-20-12/h1-2,4,6-7,9-10,22H,3,5,8,18H2,(H2,19,25)(H,23,24)/t9-,10+/s2
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n/an/a 1.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339991
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES Cc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C19H22N6O2/c1-10-3-2-4-13-11(10)7-15(23-13)17-18(19(21)26)22-8-16(25-17)24-14-5-6-27-9-12(14)20/h2-4,7-8,12,14,23H,5-6,9,20H2,1H3,(H2,21,26)(H,24,25)/t12-,14+/s2
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340006
PNG
(5-(((3S,4S)-4-Amino-1,1-dioxidotetrahydro-2H-thiop...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1[nH]c2ccccc2c1Cl
Show InChI InChI=1S/C18H19ClN6O3S/c19-14-9-3-1-2-4-11(9)24-15(14)16-17(18(21)26)22-7-13(25-16)23-12-8-29(27,28)6-5-10(12)20/h1-4,7,10,12,24H,5-6,8,20H2,(H2,21,26)(H,23,25)/t10-,12+/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50075944
PNG
(CHEMBL3415609 | US9775839, 3.1)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C18H20N6O3S/c19-11-5-6-28(26,27)9-14(11)23-15-8-21-17(18(20)25)16(24-15)13-7-10-3-1-2-4-12(10)22-13/h1-4,7-8,11,14,22H,5-6,9,19H2,(H2,20,25)(H,23,24)/t11-,14+/s2
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US Patent
n/an/a 2.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339996
PNG
(5-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)...)
Show SMILES COc1cncc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1S/C18H21N7O3/c1-27-14-6-21-5-13-9(14)4-12(23-13)16-17(18(20)26)22-7-15(25-16)24-11-2-3-28-8-10(11)19/h4-7,10-11,23H,2-3,8,19H2,1H3,(H2,20,26)(H,24,25)/t10-,11+/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339985
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1/C18H19FN6O3S/c19-10-1-2-12-9(5-10)6-13(23-12)16-17(18(21)26)22-7-15(25-16)24-14-8-29(27,28)4-3-11(14)20/h1-2,5-7,11,14,23H,3-4,8,20H2,(H2,21,26)(H,24,25)/t11-,14+/s2
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n/an/a 3.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339976
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(2-(2-oxopyrroli...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(CCN3CCCC3=O)ccc2[nH]1
Show InChI InChI=1S/C22H27N7O2/c1-13(23)11-25-18-12-26-21(22(24)31)20(28-18)17-10-15-9-14(4-5-16(15)27-17)6-8-29-7-2-3-19(29)30/h4-5,9-10,12-13,27H,2-3,6-8,11,23H2,1H3,(H2,24,31)(H,25,28)/t13-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340002
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cnccc2[nH]1
Show InChI InChI=1/C17H19N7O2/c18-10-8-26-4-2-12(10)23-14-7-21-16(17(19)25)15(24-14)13-5-9-6-20-3-1-11(9)22-13/h1,3,5-7,10,12,22H,2,4,8,18H2,(H2,19,25)(H,23,24)/t10-,12+/s2
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n/an/a 4.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340001
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES CCc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1/C20H24N6O2/c1-2-11-4-3-5-14-12(11)8-16(24-14)18-19(20(22)27)23-9-17(26-18)25-15-6-7-28-10-13(15)21/h3-5,8-9,13,15,24H,2,6-7,10,21H2,1H3,(H2,22,27)(H,25,26)/t13-,15+/s2
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n/an/a 4.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340004
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccncc2[nH]1
Show InChI InChI=1/C17H19N7O2/c18-10-8-26-4-2-11(10)23-14-7-21-16(17(19)25)15(24-14)12-5-9-1-3-20-6-13(9)22-12/h1,3,5-7,10-11,22H,2,4,8,18H2,(H2,19,25)(H,23,24)/t10-,11+/s2
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n/an/a 5.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50201711
PNG
(CHEMBL3951922 | US9775839, 2.2)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C16H18N6O/c1-9(17)7-19-13-8-20-15(16(18)23)14(22-13)12-6-10-4-2-3-5-11(10)21-12/h2-6,8-9,21H,7,17H2,1H3,(H2,18,23)(H,19,22)/t9-/s2
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n/an/a 5.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339979
PNG
(5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- ...)
Show SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1/C18H19ClN6O2/c19-10-2-1-3-12-9(10)6-14(23-12)16-17(18(21)26)22-7-15(25-16)24-13-4-5-27-8-11(13)20/h1-3,6-7,11,13,23H,4-5,8,20H2,(H2,21,26)(H,24,25)
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n/an/a 5.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339987
PNG
((R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol...)
Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H20N6O2/c1-25-9-11(18)7-20-14-8-21-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,20,23)/t11-/m1/s1
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n/an/a 6.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339995
PNG
(5-[(2-Aminoethyl)amino]-3-(5-fluoro-1H-indol-2-yl)...)
Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C15H15FN6O/c16-9-1-2-10-8(5-9)6-11(21-10)13-14(15(18)23)20-7-12(22-13)19-4-3-17/h1-2,5-7,21H,3-4,17H2,(H2,18,23)(H,19,22)
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n/an/a 13.4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340009
PNG
(5-(2-Aminoethylamino)-3-(1H-indol-2-yl)pyrazine-2-...)
Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C15H16N6O/c16-5-6-18-12-8-19-14(15(17)22)13(21-12)11-7-9-3-1-2-4-10(9)20-11/h1-4,7-8,20H,5-6,16H2,(H2,17,22)(H,18,21)
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n/an/a 13.9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340011
PNG
((R)-5-((1-amino-3-methoxypropan-2-yl)amino)-3-(1H-...)
Show SMILES COC[C@@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H20N6O2/c1-25-9-11(7-18)21-14-8-20-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,21,23)/t11-/m1/s1
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n/an/a 21.6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340012
PNG
((S)-5-((1-amino-3- methoxypropan-2- yl)amino)-3-(1...)
Show SMILES COC[C@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C17H20N6O2/c1-25-9-11(7-18)21-14-8-20-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,21,23)/t11-/s2
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n/an/a 27.2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340010
PNG
(5-{[2-Amino-3-(methylsulfonyl)propyl]amino}-3-(1H-...)
Show SMILES CS(=O)(=O)CC(N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C17H20N6O3S/c1-27(25,26)9-11(18)7-20-14-8-21-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,20,23)
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n/an/a 29.1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339988
PNG
(5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@@H]1CCS(=O)(=O)C[C@@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1/C18H20N6O3S/c19-11-5-6-28(26,27)9-14(11)23-15-8-21-17(18(20)25)16(24-15)13-7-10-3-1-2-4-12(10)22-13/h1-4,7-8,11,14,22H,5-6,9,19H2,(H2,20,25)(H,23,24)/t11-,14+/s2
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n/an/a 124n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339970
PNG
((R)-tert-butyl (1-((6-chloro-5-cyanopyrazin-2-yl)a...)
Show SMILES COC[C@@H](CNc1cnc(C#N)c(Cl)n1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C14H20ClN5O3/c1-14(2,3)23-13(21)19-9(8-22-4)6-18-11-7-17-10(5-16)12(15)20-11/h7,9H,6,8H2,1-4H3,(H,18,20)(H,19,21)/t9-/m1/s1
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n/an/a 528n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340005
PNG
((S)-5-((2-Aminopropyl)amino)-3-(phenylethynyl)pyra...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)C#Cc1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-11(17)9-19-14-10-20-15(16(18)22)13(21-14)8-7-12-5-3-2-4-6-12/h2-6,10-11H,9,17H2,1H3,(H2,18,22)(H,19,21)/t11-/m0/s1
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n/an/a 992n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340007
PNG
((2-(6-(((3S,4S)-4-amino-1,1-dioxidotetrahydro-2H-t...)
Show SMILES C[S+](C)c1c([nH]c2ccccc12)-c1nc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1S/C20H24N6O3S2/c1-30(2)19-11-5-3-4-6-13(11)25-17(19)16-18(20(22)27)23-9-15(26-16)24-14-10-31(28,29)8-7-12(14)21/h3-6,9,12,14H,7-8,10,21H2,1-2H3,(H3-,22,24,25,26,27)/p+1/t12-,14+/m0/s1
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n/an/a 2.47E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)


Article DOI: 10.1021/jm030603w
BindingDB Entry DOI: 10.7270/Q2MG7RN9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%