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Patent code US9775839

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340011
PNG
((R)-5-((1-amino-3-methoxypropan-2-yl)amino)-3-(1H-...)
Show SMILES COC[C@@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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n/an/a 21.6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50075733
PNG
(CHEMBL3415610 | US9775839, 8.5)
Show SMILES COc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
Show InChI InChI=1S/C19H22N6O3/c1-27-15-4-2-3-12-10(15)7-14(23-12)17-18(19(21)26)22-8-16(25-17)24-13-5-6-28-9-11(13)20/h2-4,7-8,11,13,23H,5-6,9,20H2,1H3,(H2,21,26)(H,24,25)/t11-,13+/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50201711
PNG
(CHEMBL3951922 | US9775839, 2.2)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C16H18N6O/c1-9(17)7-19-13-8-20-15(16(18)23)14(22-13)12-6-10-4-2-3-5-11(10)21-12/h2-6,8-9,21H,7,17H2,1H3,(H2,18,23)(H,19,22)/t9-/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339979
PNG
(5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- ...)
Show SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1
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n/an/a 5.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339984
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)cnc1C(N)=O
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n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339988
PNG
(5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@@H]1CCS(=O)(=O)C[C@@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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n/an/a 124n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339989
PNG
(5-{[(1R,2S)-2- aminocyclohexyl]amino}- 3-(4-methyl...)
Show SMILES Cc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCCC[C@@H]2N)cnc1C(N)=O
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50075944
PNG
(CHEMBL3415609 | US9775839, 3.1)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H20N6O3S/c19-11-5-6-28(26,27)9-14(11)23-15-8-21-17(18(20)25)16(24-15)13-7-10-3-1-2-4-12(10)22-13/h1-4,7-8,11,14,22H,5-6,9,19H2,(H2,20,25)(H,23,24)/t11-,14+/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339975
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(1-methyl-1H-pyr...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cnn(C)c1
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n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339976
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(2-(2-oxopyrroli...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(CCN3CCCC3=O)ccc2[nH]1
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n/an/a 3.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339978
PNG
(5-{[(2S)-2- aminopropyl]amino}-3-(4- bromo-1H-indo...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(Br)cccc2[nH]1
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n/an/a 0.400n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339979
PNG
(5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- ...)
Show SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1
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n/an/a 0.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340005
PNG
((S)-5-((2-Aminopropyl)amino)-3-(phenylethynyl)pyra...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)C#Cc1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-11(17)9-19-14-10-20-15(16(18)22)13(21-14)8-7-12-5-3-2-4-6-12/h2-6,10-11H,9,17H2,1H3,(H2,18,22)(H,19,21)/t11-/m0/s1
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n/an/a 992n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340007
PNG
((2-(6-(((3S,4S)-4-amino-1,1-dioxidotetrahydro-2H-t...)
Show SMILES C[S+](C)c1c([nH]c2ccccc12)-c1nc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)cnc1C(N)=O
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n/an/a 2.47E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339985
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1
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n/an/a 3.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339993
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340000
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES CCc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
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n/an/a 0.200n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340001
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES CCc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
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n/an/a 4.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340002
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cnccc2[nH]1
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n/an/a 4.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339987
PNG
((R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol...)
Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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n/an/a 6.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339995
PNG
(5-[(2-Aminoethyl)amino]-3-(5-fluoro-1H-indol-2-yl)...)
Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1
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n/an/a 13.4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339998
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2c3OCCOc3ccc2[nH]1
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n/an/a 0.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339999
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES COc1ccc2[nH]c(cc2c1OC)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
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n/an/a 0.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339982
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccc(F)cc2[nH]1
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n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340003
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ncccc2[nH]1
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n/an/a 1.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340008
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(pyridin-3-yl)-1...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cccnc1
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n/an/a 0.300n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340012
PNG
((S)-5-((1-amino-3- methoxypropan-2- yl)amino)-3-(1...)
Show SMILES COC[C@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339970
PNG
((R)-tert-butyl (1-((6-chloro-5-cyanopyrazin-2-yl)a...)
Show SMILES COC[C@@H](CNc1cnc(C#N)c(Cl)n1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C14H20ClN5O3/c1-14(2,3)23-13(21)19-9(8-22-4)6-18-11-7-17-10(5-16)12(15)20-11/h7,9H,6,8H2,1-4H3,(H,18,20)(H,19,21)/t9-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339977
PNG
(5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-(5-chloro-1...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(Cl)ccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339986
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(Cl)ccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340004
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccncc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340006
PNG
(5-(((3S,4S)-4-Amino-1,1-dioxidotetrahydro-2H-thiop...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1[nH]c2ccccc2c1Cl
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340010
PNG
(5-{[2-Amino-3-(methylsulfonyl)propyl]amino}-3-(1H-...)
Show SMILES CS(=O)(=O)CC(N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339994
PNG
(5-{[(2R)-2-amino-3- methoxypropyl]amino}-3- (4-met...)
Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(OC)cccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339996
PNG
(5-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)...)
Show SMILES COc1cncc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339997
PNG
(5-(((3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)C(F)(F)F
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50075732
PNG
(CHEMBL3414584 | US9775839, 2.1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H22N6O/c20-12-6-2-4-8-14(12)24-16-10-22-18(19(21)26)17(25-16)15-9-11-5-1-3-7-13(11)23-15/h1,3,5,7,9-10,12,14,23H,2,4,6,8,20H2,(H2,21,26)(H,24,25)/t12-,14+/m0/s1
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US Patent
n/an/a 0.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339974
PNG
((S)-5-((2-aminopropyl)amino)-3-(5-bromo-1H-indol-2...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(Br)ccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339981
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340009
PNG
(5-(2-Aminoethylamino)-3-(1H-indol-2-yl)pyrazine-2-...)
Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339991
PNG
(5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...)
Show SMILES Cc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339983
PNG
(5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%