BindingDB logo
myBDB logout

Patent code US9776995

Compile Data Set for Download or QSAR

Found 524 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343170
PNG
(4-(3'-chloro-2,5'-difluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(F)cc1-c1c2ccc(cc2c[nH]c1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343014
PNG
(4-(2,3'-dichloro-4'-fluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C24H15Cl2FN4O4S/c1-34-22-11-16(13-2-5-20(27)19(26)8-13)18(25)10-17(22)24-15-4-3-14(9-21(15)28-12-29-24)36(32,33)31-23-6-7-35-30-23/h2-12H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 7.80n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343169
PNG
(4-(4'-chloro-2-fluoro-5-methoxy-3'-methyl-4-biphen...)
Show SMILES COc1cc(c(F)cc1-c1c2ccc(cc2c[nH]c1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342889
PNG
(4-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Show SMILES COc1cc(c(F)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C24H16ClFN4O4S/c1-33-22-12-18(14-3-2-4-15(25)9-14)20(26)11-19(22)24-17-6-5-16(10-21(17)27-13-28-24)35(31,32)30-23-7-8-34-29-23/h2-13H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343034
PNG
(1-(3'-chloro-2-cyano-4'-fluoro-5-methoxy-4-bipheny...)
Show SMILES COc1cc(-c2ccc(F)c(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C25H15ClFN5O3S2/c1-35-23-11-19(14-2-5-22(27)21(26)10-14)16(12-28)9-20(23)24-18-4-3-17(8-15(18)6-7-29-24)37(33,34)32-25-31-30-13-36-25/h2-11,13H,1H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 9.20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343040
PNG
(1-(3'-chloro-2-cyano-5-methoxy-5'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2cc(C)cc(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H18ClN5O3S2/c1-15-7-17(9-19(27)8-15)22-12-24(35-2)23(11-18(22)13-28)25-21-4-3-20(10-16(21)5-6-29-25)37(33,34)32-26-31-30-14-36-26/h3-12,14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 11.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343041
PNG
(4-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphen...)
Show SMILES COc1cc(-c2cccc(c2)C(F)(F)F)c(cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C25H15F3N6O3S2/c1-37-22-10-19(14-3-2-4-16(7-14)25(26,27)28)15(11-29)8-20(22)23-18-6-5-17(9-21(18)30-12-31-23)39(35,36)34-24-33-32-13-38-24/h2-10,12-13H,1H3,(H,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 11.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343092
PNG
(4-(3'-chloro-5-methoxy-2-methyl-4-biphenylyl)-N-3-...)
Show SMILES COc1cc(c(C)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C25H19ClN4O4S/c1-15-10-21(23(33-2)13-20(15)16-4-3-5-17(26)11-16)25-19-7-6-18(12-22(19)27-14-28-25)35(31,32)30-24-8-9-34-29-24/h3-14H,1-2H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 12.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343046
PNG
(1-(2-cyano-4'-fluoro-5-methoxy-3'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2ccc(F)c(C)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H18FN5O3S2/c1-15-9-16(3-6-23(15)27)21-12-24(35-2)22(11-18(21)13-28)25-20-5-4-19(10-17(20)7-8-29-25)37(33,34)32-26-31-30-14-36-26/h3-12,14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 12.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343044
PNG
(1-(4'-chloro-2-cyano-5-methoxy-3'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2ccc(Cl)c(C)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H18ClN5O3S2/c1-15-9-16(3-6-23(15)27)21-12-24(35-2)22(11-18(21)13-28)25-20-5-4-19(10-17(20)7-8-29-25)37(33,34)32-26-31-30-14-36-26/h3-12,14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 13.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342904
PNG
(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Show SMILES COc1cc(c(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H17F4N3O4S/c1-36-23-14-20(15-3-2-4-17(11-15)26(28,29)30)22(27)13-21(23)25-19-6-5-18(12-16(19)7-9-31-25)38(34,35)33-24-8-10-37-32-24/h2-14H,1H3,(H,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 13.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342956
PNG
(1-(3'-chloro-2-cyano-5-methoxy-5'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2cc(C)cc(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C#N
Show InChI InChI=1S/C28H20ClN5O3S/c1-17-9-19(11-21(29)10-17)24-14-26(37-2)25(13-20(24)15-30)28-23-4-3-22(12-18(23)5-8-32-28)38(35,36)34-27-6-7-31-16-33-27/h3-14,16H,1-2H3,(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 13.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343228
PNG
(1-(2,4'-dichloro-5-methoxy-3'-methyl-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18Cl2N4O3S2/c1-14-9-15(3-6-21(14)26)19-12-23(34-2)20(11-22(19)27)24-18-5-4-17(10-16(18)7-8-28-24)36(32,33)31-25-30-29-13-35-25/h3-13H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343017
PNG
(4-(2-chloro-3',5'-difluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H15ClF2N4O4S/c1-34-22-11-18(13-6-14(26)8-15(27)7-13)20(25)10-19(22)24-17-3-2-16(9-21(17)28-12-29-24)36(32,33)31-23-4-5-35-30-23/h2-12H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 14.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342868
PNG
(1-(3'-chloro-2-cyano-4'-fluoro-5-methoxy-4-bipheny...)
Show SMILES COc1cc(-c2ccc(F)c(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N
Show InChI InChI=1S/C26H16ClFN4O4S/c1-35-24-13-20(15-2-5-23(28)22(27)12-15)17(14-29)11-21(24)26-19-4-3-18(10-16(19)6-8-30-26)37(33,34)32-25-7-9-36-31-25/h2-13H,1H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 14.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343068
PNG
(1-(2,4'-dichloro-5-methoxy-3'-methyl-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1nncc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18Cl2N4O4S/c1-14-9-15(3-6-21(14)26)19-12-23(34-2)20(11-22(19)27)25-18-5-4-17(10-16(18)13-28-29-25)36(32,33)31-24-7-8-35-30-24/h3-13H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 15.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343168
PNG
(1-(4'-chloro-2-fluoro-5-methoxy-3'-methyl-4-biphen...)
Show SMILES COc1cc(c(F)cc1-c1[nH]c(=O)cc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342905
PNG
(1-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Show SMILES COc1cc(c(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C25H17ClFN3O4S/c1-33-23-14-20(15-3-2-4-17(26)11-15)22(27)13-21(23)25-19-6-5-18(12-16(19)7-9-28-25)35(31,32)30-24-8-10-34-29-24/h2-14H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 16.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343110
PNG
(1-(5'-chloro-2',5-dimethoxy-2-methyl-4-biphenylyl)...)
Show SMILES COc1ccc(Cl)cc1-c1cc(OC)c(cc1C)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C27H22ClN3O5S/c1-16-12-23(25(35-3)15-21(16)22-14-18(28)4-7-24(22)34-2)27-20-6-5-19(13-17(20)8-10-29-27)37(32,33)31-26-9-11-36-30-26/h4-15H,1-3H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 16.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343022
PNG
(4-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphen...)
Show SMILES COc1cc(-c2cccc(c2)C(F)(F)F)c(cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N
Show InChI InChI=1S/C26H16F3N5O4S/c1-37-23-12-20(15-3-2-4-17(9-15)26(27,28)29)16(13-30)10-21(23)25-19-6-5-18(11-22(19)31-14-32-25)39(35,36)34-24-7-8-38-33-24/h2-12,14H,1H3,(H,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 16.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343069
PNG
(1-(2,3'-dichloro-5-methoxy-4'-methyl-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1nncc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C25H18Cl2N4O4S/c1-14-3-4-15(10-21(14)26)19-12-23(34-2)20(11-22(19)27)25-18-6-5-17(9-16(18)13-28-29-25)36(32,33)31-24-7-8-35-30-24/h3-13H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 17.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342958
PNG
(1-(4'-chloro-2-cyano-5-methoxy-3'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2ccc(Cl)c(C)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C#N
Show InChI InChI=1S/C28H20ClN5O3S/c1-17-11-18(3-6-25(17)29)23-14-26(37-2)24(13-20(23)15-30)28-22-5-4-21(12-19(22)7-10-32-28)38(35,36)34-27-8-9-31-16-33-27/h3-14,16H,1-2H3,(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 17.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343094
PNG
(4-(5'-chloro-2',5-dimethoxy-2-methyl-4-biphenylyl)...)
Show SMILES COc1ccc(Cl)cc1-c1cc(OC)c(cc1C)-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C26H21ClN4O5S/c1-15-10-21(24(35-3)13-19(15)20-11-16(27)4-7-23(20)34-2)26-18-6-5-17(12-22(18)28-14-29-26)37(32,33)31-25-8-9-36-30-25/h4-14H,1-3H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 18.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343093
PNG
(N-3-isoxazolyl-4-(5-methoxy-2-methyl-3'-(trifluoro...)
Show SMILES COc1cc(c(C)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H19F3N4O4S/c1-15-10-21(23(36-2)13-20(15)16-4-3-5-17(11-16)26(27,28)29)25-19-7-6-18(12-22(19)30-14-31-25)38(34,35)33-24-8-9-37-32-24/h3-14H,1-2H3,(H,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 18.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343038
PNG
(1-(4'-chloro-2-cyano-3'-fluoro-5-methoxy-4-bipheny...)
Show SMILES COc1cc(-c2ccc(Cl)c(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C25H15ClFN5O3S2/c1-35-23-11-19(14-2-5-21(26)22(27)10-14)16(12-28)9-20(23)24-18-4-3-17(8-15(18)6-7-29-24)37(33,34)32-25-31-30-13-36-25/h2-11,13H,1H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 18.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343229
PNG
(1-(2-chloro-3',5'-difluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H15ClF2N4O3S2/c1-34-22-11-19(14-6-15(26)9-16(27)7-14)21(25)10-20(22)23-18-3-2-17(8-13(18)4-5-28-23)36(32,33)31-24-30-29-12-35-24/h2-12H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342954
PNG
(1-(3'-chloro-2-cyano-4'-fluoro-5-methoxy-4-bipheny...)
Show SMILES COc1cc(-c2ccc(F)c(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C#N
Show InChI InChI=1S/C27H17ClFN5O3S/c1-37-25-13-21(16-2-5-24(29)23(28)12-16)18(14-30)11-22(25)27-20-4-3-19(10-17(20)6-9-32-27)38(35,36)34-26-7-8-31-15-33-26/h2-13,15H,1H3,(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 19.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343025
PNG
(4-(5-chloro-4-(5-fluoro-2-methoxy-3-pyridinyl)-2-m...)
Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cc(F)cnc1OC
Show InChI InChI=1S/C24H17ClFN5O5S/c1-34-21-10-16(17-7-13(26)11-27-24(17)35-2)19(25)9-18(21)23-15-4-3-14(8-20(15)28-12-29-23)37(32,33)31-22-5-6-36-30-22/h3-12H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 19.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343167
PNG
(1-(3'-chloro-2,5'-difluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(F)cc1-c1[nH]c(=O)cc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343045
PNG
(1-(3'-chloro-2-cyano-5-methoxy-4'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2ccc(C)c(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H18ClN5O3S2/c1-15-3-4-16(11-23(15)27)21-12-24(35-2)22(10-18(21)13-28)25-20-6-5-19(9-17(20)7-8-29-25)37(33,34)32-26-31-30-14-36-26/h3-12,14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 20.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342907
PNG
(1-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphen...)
Show SMILES COc1cc(-c2cccc(c2)C(F)(F)F)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncon1)C#N
Show InChI InChI=1S/C26H16F3N5O4S/c1-37-23-12-21(15-3-2-4-18(9-15)26(27,28)29)17(13-30)11-22(23)24-20-6-5-19(10-16(20)7-8-31-24)39(35,36)34-25-32-14-38-33-25/h2-12,14H,1H3,(H,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343016
PNG
(4-(2,4'-dichloro-5-methoxy-3'-methyl-4-biphenylyl)...)
Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18Cl2N4O4S/c1-14-9-15(3-6-20(14)26)18-12-23(34-2)19(11-21(18)27)25-17-5-4-16(10-22(17)28-13-29-25)36(32,33)31-24-7-8-35-30-24/h3-13H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 21.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342899
PNG
(1-(3'-chloro-2-cyano-5-methoxy-4-biphenylyl)-N-3-i...)
Show SMILES COc1cc(-c2cccc(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N
Show InChI InChI=1S/C26H17ClN4O4S/c1-34-24-14-22(16-3-2-4-19(27)11-16)18(15-28)13-23(24)26-21-6-5-20(12-17(21)7-9-29-26)36(32,33)31-25-8-10-35-30-25/h2-14H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 21.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343036
PNG
(1-(2-cyano-3'-fluoro-5-methoxy-5'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2cc(C)cc(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H18FN5O3S2/c1-15-7-17(9-19(27)8-15)22-12-24(35-2)23(11-18(22)13-28)25-21-4-3-20(10-16(21)5-6-29-25)37(33,34)32-26-31-30-14-36-26/h3-12,14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 21.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343132
PNG
(4-(3'-chloro-2,5'-difluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(F)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C24H15ClF2N4O4S/c1-34-22-11-18(13-6-14(25)8-15(26)7-13)20(27)10-19(22)24-17-3-2-16(9-21(17)28-12-29-24)36(32,33)31-23-4-5-35-30-23/h2-12H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343029
PNG
(1-(2-cyano-5-methoxy-3'-methyl-4-biphenylyl)-N-1,3...)
Show SMILES COc1cc(-c2cccc(C)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H19N5O3S2/c1-16-4-3-5-17(10-16)22-13-24(34-2)23(12-19(22)14-27)25-21-7-6-20(11-18(21)8-9-28-25)36(32,33)31-26-30-29-15-35-26/h3-13,15H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 22.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343113
PNG
(1-(3'-chloro-4'-fluoro-5-methoxy-2-methyl-4-biphen...)
Show SMILES COc1cc(c(C)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H19ClFN3O4S/c1-15-11-21(24(34-2)14-20(15)16-3-6-23(28)22(27)13-16)26-19-5-4-18(12-17(19)7-9-29-26)36(32,33)31-25-8-10-35-30-25/h3-14H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 22.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342886
PNG
(4-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Show SMILES COc1cc(c(F)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H16F4N4O4S/c1-36-22-12-18(14-3-2-4-15(9-14)25(27,28)29)20(26)11-19(22)24-17-6-5-16(10-21(17)30-13-31-24)38(34,35)33-23-7-8-37-32-23/h2-13H,1H3,(H,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 22.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343030
PNG
(1-(2-cyano-3'-fluoro-5-methoxy-4'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2ccc(C)c(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H18FN5O3S2/c1-15-3-4-16(11-23(15)27)21-12-24(35-2)22(10-18(21)13-28)25-20-6-5-19(9-17(20)7-8-29-25)37(33,34)32-26-31-30-14-36-26/h3-12,14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 22.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343096
PNG
(4-(3'-chloro-5-methoxy-2,5'-dimethyl-4-biphenylyl)...)
Show SMILES COc1cc(c(C)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cc(C)cc(Cl)c1
Show InChI InChI=1S/C26H21ClN4O4S/c1-15-8-17(11-18(27)9-15)21-13-24(34-3)22(10-16(21)2)26-20-5-4-19(12-23(20)28-14-29-26)36(32,33)31-25-6-7-35-30-25/h4-14H,1-3H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 23.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342888
PNG
(4-(4'-chloro-2-fluoro-5-methoxy-3'-methyl-4-biphen...)
Show SMILES COc1cc(c(F)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18ClFN4O4S/c1-14-9-15(3-6-20(14)26)18-12-23(34-2)19(11-21(18)27)25-17-5-4-16(10-22(17)28-13-29-25)36(32,33)31-24-7-8-35-30-24/h3-13H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342870
PNG
(1-(3'-chloro-2-cyano-5'-fluoro-5-methoxy-4-bipheny...)
Show SMILES COc1cc(-c2cc(F)cc(Cl)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N
Show InChI InChI=1S/C26H16ClFN4O4S/c1-35-24-13-22(16-8-18(27)12-19(28)9-16)17(14-29)11-23(24)26-21-3-2-20(10-15(21)4-6-30-26)37(33,34)32-25-5-7-36-31-25/h2-13H,1H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 24.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343097
PNG
(4-(3'-chloro-4'-fluoro-5-methoxy-2-methyl-4-biphen...)
Show SMILES COc1cc(c(C)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C25H18ClFN4O4S/c1-14-9-19(23(34-2)12-18(14)15-3-6-21(27)20(26)10-15)25-17-5-4-16(11-22(17)28-13-29-25)36(32,33)31-24-7-8-35-30-24/h3-13H,1-2H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 25.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343031
PNG
(1-(2-cyano-5-methoxy-4'-(trifluoromethyl)-4-biphen...)
Show SMILES COc1cc(-c2ccc(cc2)C(F)(F)F)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C26H16F3N5O3S2/c1-37-23-12-21(15-2-4-18(5-3-15)26(27,28)29)17(13-30)11-22(23)24-20-7-6-19(10-16(20)8-9-31-24)39(35,36)34-25-33-32-14-38-25/h2-12,14H,1H3,(H,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 25.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343130
PNG
(4-(3',5'-dichloro-2-fluoro-5-methoxy-4-biphenylyl)...)
Show SMILES COc1cc(c(F)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C24H15Cl2FN4O4S/c1-34-22-11-18(13-6-14(25)8-15(26)7-13)20(27)10-19(22)24-17-3-2-16(9-21(17)28-12-29-24)36(32,33)31-23-4-5-35-30-23/h2-12H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342866
PNG
(1-(4'-chloro-2-cyano-5-methoxy-3'-methyl-4-bipheny...)
Show SMILES COc1cc(-c2ccc(Cl)c(C)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N
Show InChI InChI=1S/C27H19ClN4O4S/c1-16-11-17(3-6-24(16)28)22-14-25(35-2)23(13-19(22)15-29)27-21-5-4-20(12-18(21)7-9-30-27)37(33,34)32-26-8-10-36-31-26/h3-14H,1-2H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 26.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM342945
PNG
(1-(2,3''-difluoro-5-methoxy-4-biphenylyl)-N-3-isox...)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
Show InChI InChI=1S/C25H17F2N3O5S/c1-34-23-13-19(15-3-2-4-17(26)11-15)20(27)14-22(23)30-21-7-6-18(12-16(21)5-8-25(30)31)36(32,33)29-24-9-10-35-28-24/h2-14H,1H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343165
PNG
(4-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Show SMILES COc1cc(c(Cl)cc1-c1c2ccc(cc2c[nH]c1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343171
PNG
((P)-1-(2-fluoro-5-methoxy-3''-(trifluoromethyl)-4-...)
Show SMILES COc1cc(c(F)cc1-c1n(C)c(=O)cc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H19F4N3O5S/c1-34-25(35)12-16-11-18(40(36,37)33-24-8-9-39-32-24)6-7-19(16)26(34)21-13-22(28)20(14-23(21)38-2)15-4-3-5-17(10-15)27(29,30)31/h3-14H,1-2H3,(H,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM343225
PNG
(4-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-1,...)
Show SMILES COc1cc(c(F)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ncon1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H15ClFN5O4S/c1-33-21-10-17(13-3-2-4-14(24)7-13)19(25)9-18(21)22-16-6-5-15(8-20(16)26-11-27-22)35(31,32)30-23-28-12-34-29-23/h2-12H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9776995 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 524 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%