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Patent code US9777000

Compile Data Set for Download or QSAR
Found 173 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343236
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-1-meth...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H15ClF2N6OS/c1-30-18(14(10-26-30)22-29-17(20(24)25)19(23)33-22)21(32)27-13-7-8-31-11-15(28-16(31)9-13)12-5-3-2-4-6-12/h2-11,20H,1H3,(H,27,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343237
PNG
(1-methyl-4-(5-methyl-1,3,4-thiadiazol-2-yl)-N-(2-p...)
Show SMILES Cc1nnc(s1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H21N7OS/c1-13-25-26-21(30-13)16-11-22-27(2)19(16)20(29)23-15-8-9-28-12-17(24-18(28)10-15)14-6-4-3-5-7-14/h3-7,11-12,15H,8-10H2,1-2H3,(H,23,29)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343244
PNG
(N-(2-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F4N6OS/c1-31-19(15(9-27-31)21-30-17(11-34-21)22(24,25)26)20(33)28-14-5-6-32-10-16(29-18(32)8-14)12-3-2-4-13(23)7-12/h2-4,7,9-11,14H,5-6,8H2,1H3,(H,28,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343245
PNG
(1-methyl-4-(6-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1cccc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O/c1-16-7-6-10-20(26-16)19-14-25-29(2)23(19)24(31)27-18-11-12-30-15-21(28-22(30)13-18)17-8-4-3-5-9-17/h3-10,14-15,18H,11-13H2,1-2H3,(H,27,31)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343237
PNG
(1-methyl-4-(5-methyl-1,3,4-thiadiazol-2-yl)-N-(2-p...)
Show SMILES Cc1nnc(s1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H21N7OS/c1-13-25-26-21(30-13)16-11-22-27(2)19(16)20(29)23-15-8-9-28-12-17(24-18(28)10-15)14-6-4-3-5-7-14/h3-7,11-12,15H,8-10H2,1-2H3,(H,23,29)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343269
PNG
(4-(2,6-dimethoxypyrimidin-4-yl)-N-(6-fluoro-2-phen...)
Show SMILES COc1cc(nc(OC)n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O3/c1-31-20(14(11-25-31)16-10-19(34-2)29-23(27-16)35-3)22(33)26-17-9-18-28-21(13-7-5-4-6-8-13)30-32(18)12-15(17)24/h4-12H,1-3H3,(H,26,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343273
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1ccc(F)cn1
Show InChI InChI=1S/C22H15F2N7O/c1-30-20(15(11-26-30)17-8-7-14(23)10-25-17)22(32)27-18-9-19-28-21(13-5-3-2-4-6-13)29-31(19)12-16(18)24/h2-12H,1H3,(H,27,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343278
PNG
(4-(3-cyanopyridin-2-yl)-N-(6-fluoro-2-phenyl-[1,2,...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1ncccc1C#N
Show InChI InChI=1S/C23H15FN8O/c1-31-21(16(12-27-31)20-15(11-25)8-5-9-26-20)23(33)28-18-10-19-29-22(14-6-3-2-4-7-14)30-32(19)13-17(18)24/h2-10,12-13H,1H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343302
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1nc(C)c(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C24H21FN8O/c1-13-14(2)27-15(3)28-21(13)17-11-26-32(4)22(17)24(34)29-19-10-20-30-23(16-8-6-5-7-9-16)31-33(20)12-18(19)25/h5-12H,1-4H3,(H,29,34)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343306
PNG
(4-(5-chloro-2-methylpyrimidin-4-yl)-N-(6-fluoro-2-...)
Show SMILES Cc1ncc(Cl)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H16ClFN8O/c1-12-25-10-15(23)19(27-12)14-9-26-31(2)20(14)22(33)28-17-8-18-29-21(13-6-4-3-5-7-13)30-32(18)11-16(17)24/h3-11H,1-2H3,(H,28,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343307
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1cncc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O2/c1-30-20(14(9-25-30)17-10-24-11-19(26-17)33-2)22(32)27-16-8-18-28-21(13-6-4-3-5-7-13)29-31(18)12-15(16)23/h3-12H,1-2H3,(H,27,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343311
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1cnnc(c1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-8-17(28-24-10-13)15-11-25-30(2)20(15)22(32)26-18-9-19-27-21(14-6-4-3-5-7-14)29-31(19)12-16(18)23/h3-12H,1-2H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343320
PNG
((S)-1-methyl-N-(2-(2-methylpyrrolidin-1-yl)-[1,2,4...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(cs3)C(F)(F)F)ccn2n1
Show InChI InChI=1S/C20H19F3N8OS/c1-11-4-3-6-30(11)19-27-15-8-12(5-7-31(15)28-19)25-17(32)16-13(9-24-29(16)2)18-26-14(10-33-18)20(21,22)23/h5,7-11H,3-4,6H2,1-2H3,(H,25,32)/t11-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343323
PNG
((S)-1-methyl-4-(4-methylpyridin-2-yl)-N-(2-(2-meth...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3cc(C)ccn3)ccn2n1
Show InChI InChI=1S/C22H24N8O/c1-14-6-8-23-18(11-14)17-13-24-28(3)20(17)21(31)25-16-7-10-30-19(12-16)26-22(27-30)29-9-4-5-15(29)2/h6-8,10-13,15H,4-5,9H2,1-3H3,(H,25,31)/t15-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343340
PNG
((S)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C19H16F4N8OS/c1-29-15(12(7-24-29)17-26-13(9-33-17)19(21,22)23)16(32)25-11-3-5-31-14(6-11)27-18(28-31)30-4-2-10(20)8-30/h3,5-7,9-10H,2,4,8H2,1H3,(H,25,32)/t10-/m0/s1
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343322
PNG
(1-methyl-4-(4-methylpyridin-2-yl)-N-(2-(pyrrolidin...)
Show SMILES Cc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C21H22N8O/c1-14-5-7-22-17(11-14)16-13-23-27(2)19(16)20(30)24-15-6-10-29-18(12-15)25-21(26-29)28-8-3-4-9-28/h5-7,10-13H,3-4,8-9H2,1-2H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343351
PNG
(4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-1-meth...)
Show SMILES Cc1sc(nc1C(F)F)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C20H20F2N8OS/c1-11-15(17(21)22)26-19(32-11)13-10-23-28(2)16(13)18(31)24-12-5-8-30-14(9-12)25-20(27-30)29-6-3-4-7-29/h5,8-10,17H,3-4,6-7H2,1-2H3,(H,24,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343353
PNG
(4-(2,5-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-(pyrr...)
Show SMILES Cc1ncc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)N1CCCC1
Show InChI InChI=1S/C21H22FN9O/c1-12-9-23-13(2)25-18(12)14-10-24-29(3)19(14)20(32)26-16-8-17-27-21(30-6-4-5-7-30)28-31(17)11-15(16)22/h8-11H,4-7H2,1-3H3,(H,26,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343361
PNG
(4-(5-bromo-4-methylthiazol-2-yl)-1-methyl-N-(2-phe...)
Show SMILES Cc1nc(sc1Br)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H20BrN7OS/c1-12-18(22)31-21(24-12)15-11-23-28(2)17(15)20(30)25-14-8-9-29-16(10-14)26-19(27-29)13-6-4-3-5-7-13/h3-7,11,14H,8-10H2,1-2H3,(H,25,30)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343231
PNG
(1-methyl-4-(4-methylthiazol-2-yl)-N-(2-phenylimida...)
Show SMILES Cc1csc(n1)-c1cnn(C)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H18N6OS/c1-14-13-30-22(24-14)17-11-23-27(2)20(17)21(29)25-16-8-9-28-12-18(26-19(28)10-16)15-6-4-3-5-7-15/h3-13H,1-2H3,(H,25,29)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343270
PNG
(4-(2,5-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-(o-to...)
Show SMILES Cc1ncc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1C
Show InChI InChI=1S/C24H21FN8O/c1-13-7-5-6-8-16(13)23-30-20-9-19(18(25)12-33(20)31-23)29-24(34)22-17(11-27-32(22)4)21-14(2)10-26-15(3)28-21/h5-12H,1-4H3,(H,29,34)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343271
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C21H13F4N7OS/c1-31-17(12(8-26-31)20-28-15(10-34-20)21(23,24)25)19(33)27-14-7-16-29-18(11-5-3-2-4-6-11)30-32(16)9-13(14)22/h2-10H,1H3,(H,27,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343279
PNG
(4-(3,6-dimethyl-pyrazin-2-yl)-N-(6-fluoro-2-phenyl...)
Show SMILES Cc1cnc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O/c1-13-10-25-14(2)20(27-13)16-11-26-31(3)21(16)23(33)28-18-9-19-29-22(15-7-5-4-6-8-15)30-32(19)12-17(18)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343280
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-1-methyl-N-(2-p...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C21H15F2N7OS/c1-29-17(14(10-24-29)21-26-15(11-32-21)18(22)23)20(31)25-13-7-8-30-16(9-13)27-19(28-30)12-5-3-2-4-6-12/h2-11,18H,1H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343267
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-1-meth...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C21H14ClF2N7OS/c1-30-16(13(10-25-30)21-28-15(18(23)24)17(22)33-21)20(32)26-12-7-8-31-14(9-12)27-19(29-31)11-5-3-2-4-6-11/h2-10,18H,1H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343291
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1nccc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O2/c1-30-19(14(11-25-30)16-8-9-24-22(27-16)33-2)21(32)26-17-10-18-28-20(13-6-4-3-5-7-13)29-31(18)12-15(17)23/h3-12H,1-2H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343292
PNG
(4-(5-fluoro-2-methoxypyrimidin-4-yl)-N-(6-fluoro-2...)
Show SMILES COc1ncc(F)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H16F2N8O2/c1-31-19(13(9-26-31)18-14(23)10-25-22(29-18)34-2)21(33)27-16-8-17-28-20(12-6-4-3-5-7-12)30-32(17)11-15(16)24/h3-11H,1-2H3,(H,27,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343312
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1cccnn1
Show InChI InChI=1S/C21H15FN8O/c1-29-19(14(11-24-29)16-8-5-9-23-27-16)21(31)25-17-10-18-26-20(13-6-3-2-4-7-13)28-30(18)12-15(17)22/h2-12H,1H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343314
PNG
(4-(2,5-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-(pyri...)
Show SMILES Cc1ncc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1cccnc1
Show InChI InChI=1S/C22H18FN9O/c1-12-8-25-13(2)27-19(12)15-10-26-31(3)20(15)22(33)28-17-7-18-29-21(14-5-4-6-24-9-14)30-32(18)11-16(17)23/h4-11H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343317
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H18FN7O2/c1-30-21(16(12-26-30)18-10-15(33-2)8-9-25-18)23(32)27-19-11-20-28-22(14-6-4-3-5-7-14)29-31(20)13-17(19)24/h3-13H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343325
PNG
((S)-1-methyl-4-(6-methylpyrazin-2-yl)-N-(2-(2-meth...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3cncc(C)n3)ccn2n1
Show InChI InChI=1S/C21H23N9O/c1-13-10-22-12-17(24-13)16-11-23-28(3)19(16)20(31)25-15-6-8-30-18(9-15)26-21(27-30)29-7-4-5-14(29)2/h6,8-12,14H,4-5,7H2,1-3H3,(H,25,31)/t14-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343326
PNG
((S)-1-methyl-4-(6-methylpyridin-2-yl)-N-(2-(2-meth...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3cccc(C)n3)ccn2n1
Show InChI InChI=1S/C22H24N8O/c1-14-6-4-8-18(24-14)17-13-23-28(3)20(17)21(31)25-16-9-11-30-19(12-16)26-22(27-30)29-10-5-7-15(29)2/h4,6,8-9,11-13,15H,5,7,10H2,1-3H3,(H,25,31)/t15-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343330
PNG
((R)-N-(6-fluoro-2-(2trifluoromethyl)pyrrolidin-1-y...)
Show SMILES Cc1cccc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)N1CCC[C@@H]1C(F)(F)F
Show InChI InChI=1S/C22H20F4N8O/c1-12-5-3-6-15(28-12)13-10-27-32(2)19(13)20(35)29-16-9-18-30-21(31-34(18)11-14(16)23)33-8-4-7-17(33)22(24,25)26/h3,5-6,9-11,17H,4,7-8H2,1-2H3,(H,29,35)/t17-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343333
PNG
((S)-4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(3-flu...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C19H17F3N8OS/c1-28-15(12(7-23-28)18-25-13(9-32-18)16(21)22)17(31)24-11-3-5-30-14(6-11)26-19(27-30)29-4-2-10(20)8-29/h3,5-7,9-10,16H,2,4,8H2,1H3,(H,24,31)/t10-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343321
PNG
((S)-4-(4,6-dimethylpyridin-2-yl)-N-(2-(3-fluoropyr...)
Show SMILES Cc1cc(C)nc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C22H23FN8O/c1-13-8-14(2)25-18(9-13)17-11-24-29(3)20(17)21(32)26-16-5-7-31-19(10-16)27-22(28-31)30-6-4-15(23)12-30/h5,7-11,15H,4,6,12H2,1-3H3,(H,26,32)/t15-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343343
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-1-methyl-N-(2-(...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C19H18F2N8OS/c1-27-15(12(9-22-27)18-24-13(10-31-18)16(20)21)17(30)23-11-4-7-29-14(8-11)25-19(26-29)28-5-2-3-6-28/h4,7-10,16H,2-3,5-6H2,1H3,(H,23,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343357
PNG
(4-(5-acetyl-2-methylthiazol-4-yl)-1-methyl-N-(2-ph...)
Show SMILES CC(=O)c1sc(C)nc1-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O2S/c1-13(31)21-19(25-14(2)33-21)17-12-24-29(3)20(17)23(32)26-16-9-10-30-18(11-16)27-22(28-30)15-7-5-4-6-8-15/h4-8,12,16H,9-11H2,1-3H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343359
PNG
(4-(4-(difluoromethyl)-5-vinylthiazol-2-yl)-1-methy...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(C=C)s2)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H21F2N7OS/c1-3-16-18(20(24)25)29-23(34-16)15-12-26-31(2)19(15)22(33)27-14-9-10-32-17(11-14)28-21(30-32)13-7-5-4-6-8-13/h3-8,12,14,20H,1,9-11H2,2H3,(H,27,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343360
PNG
(4-(4-(difluoromethyl)-5-ethylthiazol-2-yl)-1-methy...)
Show SMILES CCc1sc(nc1C(F)F)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23F2N7OS/c1-3-16-18(20(24)25)29-23(34-16)15-12-26-31(2)19(15)22(33)27-14-9-10-32-17(11-14)28-21(30-32)13-7-5-4-6-8-13/h4-8,12,14,20H,3,9-11H2,1-2H3,(H,27,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343400
PNG
(1-methyl-N-(2-(pyrrolidin-1-yl)-5,6,7,8-tetrahydro...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)NC1CCn2nc(nc2C1)N1CCCC1
Show InChI InChI=1S/C19H21F3N8OS/c1-28-15(12(9-23-28)17-25-13(10-32-17)19(20,21)22)16(31)24-11-4-7-30-14(8-11)26-18(27-30)29-5-2-3-6-29/h9-11H,2-8H2,1H3,(H,24,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343235
PNG
(1-methyl-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)-4-...)
Show SMILES Cn1ncc(c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C24H17F3N6O/c1-32-22(17(13-28-32)18-8-5-9-20(30-18)24(25,26)27)23(34)29-16-10-11-33-14-19(31-21(33)12-16)15-6-3-2-4-7-15/h2-14H,1H3,(H,29,34)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343255
PNG
(N-(3-fluoro-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)NC1CCn2c(C1)nc(c2F)-c1ccccc1
Show InChI InChI=1S/C22H18F4N6OS/c1-31-18(14(10-27-31)21-29-15(11-34-21)22(24,25)26)20(33)28-13-7-8-32-16(9-13)30-17(19(32)23)12-5-3-2-4-6-12/h2-6,10-11,13H,7-9H2,1H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343238
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(3-fluorop...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C22H19F3N6OS/c1-30-19(15(9-26-30)22-29-17(11-33-22)20(24)25)21(32)27-14-5-6-31-10-16(28-18(31)8-14)12-3-2-4-13(23)7-12/h2-4,7,9-11,14,20H,5-6,8H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343266
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C23H15F4N7O/c1-33-20(14(11-28-33)16-8-5-9-18(29-16)23(25,26)27)22(35)30-17-10-19-31-21(13-6-3-2-4-7-13)32-34(19)12-15(17)24/h2-12H,1H3,(H,30,35)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343268
PNG
(4-(2,6-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-pheny...)
Show SMILES Cc1cc(nc(C)n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O/c1-13-9-18(27-14(2)26-13)16-11-25-31(3)21(16)23(33)28-19-10-20-29-22(15-7-5-4-6-8-15)30-32(20)12-17(19)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343266
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C23H15F4N7O/c1-33-20(14(11-28-33)16-8-5-9-18(29-16)23(25,26)27)22(35)30-17-10-19-31-21(13-6-3-2-4-7-13)32-34(19)12-15(17)24/h2-12H,1H3,(H,30,35)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343296
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1ncnc(-c2cnn(C)c2C(=O)Nc2cc3nc(nn3cc2F)-c2ccccc2)c1C
Show InChI InChI=1S/C23H19FN8O2/c1-13-19(25-12-26-23(13)34-3)15-10-27-31(2)20(15)22(33)28-17-9-18-29-21(14-7-5-4-6-8-14)30-32(18)11-16(17)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343299
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1cncnc1-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O2/c1-30-20(14(9-26-30)19-17(33-2)10-24-12-25-19)22(32)27-16-8-18-28-21(13-6-4-3-5-7-13)29-31(18)11-15(16)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343304
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1cc(ncn1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-8-17(25-12-24-13)15-10-26-30(2)20(15)22(32)27-18-9-19-28-21(14-6-4-3-5-7-14)29-31(19)11-16(18)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343308
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1ccnc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-8-9-24-21(26-13)15-11-25-30(2)19(15)22(32)27-17-10-18-28-20(14-6-4-3-5-7-14)29-31(18)12-16(17)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343322
PNG
(1-methyl-4-(4-methylpyridin-2-yl)-N-(2-(pyrrolidin...)
Show SMILES Cc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C21H22N8O/c1-14-5-7-22-17(11-14)16-13-23-27(2)19(16)20(30)24-15-6-10-29-18(12-15)25-21(26-29)28-8-3-4-9-28/h5-7,10-13H,3-4,8-9H2,1-2H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343320
PNG
((S)-1-methyl-N-(2-(2-methylpyrrolidin-1-yl)-[1,2,4...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(cs3)C(F)(F)F)ccn2n1
Show InChI InChI=1S/C20H19F3N8OS/c1-11-4-3-6-30(11)19-27-15-8-12(5-7-31(15)28-19)25-17(32)16-13(9-24-29(16)2)18-26-14(10-33-18)20(21,22)23/h5,7-11H,3-4,6H2,1-2H3,(H,25,32)/t11-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343336
PNG
((S)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES COc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C21H21FN8O2/c1-28-19(16(11-24-28)17-10-15(32-2)3-6-23-17)20(31)25-14-5-8-30-18(9-14)26-21(27-30)29-7-4-13(22)12-29/h3,5-6,8-11,13H,4,7,12H2,1-2H3,(H,25,31)/t13-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343341
PNG
((S)-4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-N-...)
Show SMILES Cc1sc(nc1C(F)F)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C20H19F3N8OS/c1-10-15(17(22)23)27-19(33-10)13-8-24-29(2)16(13)18(32)25-12-4-6-31-14(7-12)26-20(28-31)30-5-3-11(21)9-30/h4,6-8,11,17H,3,5,9H2,1-2H3,(H,25,32)/t11-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343345
PNG
(1-methyl-N-(2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,...)
Show SMILES Cn1ncc(c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N8O/c1-30-18(14(12-25-30)15-5-4-6-16(27-15)21(22,23)24)19(33)26-13-7-10-32-17(11-13)28-20(29-32)31-8-2-3-9-31/h4-7,10-12H,2-3,8-9H2,1H3,(H,26,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343399
PNG
(4-(4,5-dimethylthiazol-2-yl)-1-methyl-N-(2-(pyrrol...)
Show SMILES Cc1nc(sc1C)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)N1CCCC1
Show InChI InChI=1S/C20H26N8OS/c1-12-13(2)30-19(22-12)15-11-21-26(3)17(15)18(29)23-14-6-9-28-16(10-14)24-20(25-28)27-7-4-5-8-27/h11,14H,4-10H2,1-3H3,(H,23,29)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343232
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-1-methyl-N-(2-p...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H16F2N6OS/c1-29-19(15(10-25-29)22-28-17(12-32-22)20(23)24)21(31)26-14-7-8-30-11-16(27-18(30)9-14)13-5-3-2-4-6-13/h2-12,20H,1H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343243
PNG
(4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-N-(2-(...)
Show SMILES Cc1sc(nc1CF)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22F2N6OS/c1-13-18(10-24)29-23(33-13)17-11-26-30(2)21(17)22(32)27-16-6-7-31-12-19(28-20(31)9-16)14-4-3-5-15(25)8-14/h3-5,8,11-12,16H,6-7,9-10H2,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343264
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(4-fluorop...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19F3N6OS/c1-30-19(15(9-26-30)22-29-17(11-33-22)20(24)25)21(32)27-14-6-7-31-10-16(28-18(31)8-14)12-2-4-13(23)5-3-12/h2-5,9-11,14,20H,6-8H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343267
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-1-meth...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C21H14ClF2N7OS/c1-30-16(13(10-25-30)21-28-15(18(23)24)17(22)33-21)20(32)26-12-7-8-31-14(9-12)27-19(29-31)11-5-3-2-4-6-11/h2-10,18H,1H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343281
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(2-methoxy...)
Show SMILES COc1ccccc1-c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(cs3)C(F)F)ccn2n1
Show InChI InChI=1S/C22H17F2N7O2S/c1-30-18(14(10-25-30)22-27-15(11-34-22)19(23)24)21(32)26-12-7-8-31-17(9-12)28-20(29-31)13-5-3-4-6-16(13)33-2/h3-11,19H,1-2H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343283
PNG
(4-(4-ethylthiazol-2-yl)-1-methyl-N-(2-phenyl-[1,2,...)
Show SMILES CCc1csc(n1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H19N7OS/c1-3-15-13-31-22(25-15)17-12-23-28(2)19(17)21(30)24-16-9-10-29-18(11-16)26-20(27-29)14-7-5-4-6-8-14/h4-13H,3H2,1-2H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343297
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1nccnc1-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-19(25-9-8-24-13)15-11-26-30(2)20(15)22(32)27-17-10-18-28-21(14-6-4-3-5-7-14)29-31(18)12-16(17)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343301
PNG
(4-(5-fluoro-2-methylpyrimidin-4-yl)-N-(6-fluoro-2-...)
Show SMILES Cc1ncc(F)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H16F2N8O/c1-12-25-10-15(23)19(27-12)14-9-26-31(2)20(14)22(33)28-17-8-18-29-21(13-6-4-3-5-7-13)30-32(18)11-16(17)24/h3-11H,1-2H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343324
PNG
((S)-4-(4-methoxypyridin-2-yl)-1-methyl-N-(2-(2-met...)
Show SMILES COc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCC[C@@H]1C
Show InChI InChI=1S/C22H24N8O2/c1-14-5-4-9-29(14)22-26-19-11-15(7-10-30(19)27-22)25-21(31)20-17(13-24-28(20)2)18-12-16(32-3)6-8-23-18/h6-8,10-14H,4-5,9H2,1-3H3,(H,25,31)/t14-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343327
PNG
((S)-4-(4,6-dimethylpyridin-2-yl)-1-methyl-N-(2-(2-...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3cc(C)cc(C)n3)ccn2n1
Show InChI InChI=1S/C23H26N8O/c1-14-10-15(2)25-19(11-14)18-13-24-29(4)21(18)22(32)26-17-7-9-31-20(12-17)27-23(28-31)30-8-5-6-16(30)3/h7,9-13,16H,5-6,8H2,1-4H3,(H,26,32)/t16-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343352
PNG
(1-methyl-N-(2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C19H17F3N8OS/c1-28-15(12(9-23-28)17-25-13(10-32-17)19(20,21)22)16(31)24-11-4-7-30-14(8-11)26-18(27-30)29-5-2-3-6-29/h4,7-10H,2-3,5-6H2,1H3,(H,24,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343371
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-1-methyl-N-(2-p...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H19F2N7OS/c1-29-17(14(10-24-29)21-26-15(11-32-21)18(22)23)20(31)25-13-7-8-30-16(9-13)27-19(28-30)12-5-3-2-4-6-12/h2-6,10-11,13,18H,7-9H2,1H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343233
PNG
(4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-1-meth...)
Show SMILES Cc1sc(nc1C(F)F)-c1cnn(C)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H18F2N6OS/c1-13-19(21(24)25)29-23(33-13)16-11-26-30(2)20(16)22(32)27-15-8-9-31-12-17(28-18(31)10-15)14-6-4-3-5-7-14/h3-12,21H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343234
PNG
(1-methyl-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)-4-...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H15F3N6OS/c1-30-19(15(10-26-30)21-29-17(12-33-21)22(23,24)25)20(32)27-14-7-8-31-11-16(28-18(31)9-14)13-5-3-2-4-6-13/h2-12H,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343239
PNG
(1-methyl-N-(2-phenyl-5,6,7,8-tetrahydroimidazo[1,2...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H19F3N6OS/c1-30-19(15(10-26-30)21-29-17(12-33-21)22(23,24)25)20(32)27-14-7-8-31-11-16(28-18(31)9-14)13-5-3-2-4-6-13/h2-6,10-12,14H,7-9H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343240
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-1-methyl-N-(2-p...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H20F2N6OS/c1-29-19(15(10-25-29)22-28-17(12-32-22)20(23)24)21(31)26-14-7-8-30-11-16(27-18(30)9-14)13-5-3-2-4-6-13/h2-6,10-12,14,20H,7-9H2,1H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343250
PNG
(4-(3-isopropyl-1,2,4-thiadiazol-5-yl)-1-methyl-N-(...)
Show SMILES CC(C)c1nsc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H25N7OS/c1-14(2)21-27-23(32-28-21)17-12-24-29(3)20(17)22(31)25-16-9-10-30-13-18(26-19(30)11-16)15-7-5-4-6-8-15/h4-8,12-14,16H,9-11H2,1-3H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343251
PNG
(1-methyl-4-(5-methylthiazol-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1cnc(s1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H22N6OS/c1-14-11-23-22(30-14)17-12-24-27(2)20(17)21(29)25-16-8-9-28-13-18(26-19(28)10-16)15-6-4-3-5-7-15/h3-7,11-13,16H,8-10H2,1-2H3,(H,25,29)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343282
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(3-fluorop...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1ccn2nc(nc2c1)-c1cccc(F)c1
Show InChI InChI=1S/C21H14F3N7OS/c1-30-17(14(9-25-30)21-27-15(10-33-21)18(23)24)20(32)26-13-5-6-31-16(8-13)28-19(29-31)11-3-2-4-12(22)7-11/h2-10,18H,1H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343288
PNG
(4-(5-cyanopyridin-2-yl)-N-(6-fluoro-2-phenyl-[1,2,...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1ccc(cn1)C#N
Show InChI InChI=1S/C23H15FN8O/c1-31-21(16(12-27-31)18-8-7-14(10-25)11-26-18)23(33)28-19-9-20-29-22(15-5-3-2-4-6-15)30-32(20)13-17(19)24/h2-9,11-13H,1H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343300
PNG
(4-(5,6-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-pheny...)
Show SMILES Cc1ncnc(-c2cnn(C)c2C(=O)Nc2cc3nc(nn3cc2F)-c2ccccc2)c1C
Show InChI InChI=1S/C23H19FN8O/c1-13-14(2)25-12-26-20(13)16-10-27-31(3)21(16)23(33)28-18-9-19-29-22(15-7-5-4-6-8-15)30-32(19)11-17(18)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343310
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1ccc(nn1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-8-9-17(28-27-13)15-11-24-30(2)20(15)22(32)25-18-10-19-26-21(14-6-4-3-5-7-14)29-31(19)12-16(18)23/h3-12H,1-2H3,(H,25,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343270
PNG
(4-(2,5-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-(o-to...)
Show SMILES Cc1ncc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1C
Show InChI InChI=1S/C24H21FN8O/c1-13-7-5-6-8-16(13)23-30-20-9-19(18(25)12-33(20)31-23)29-24(34)22-17(11-27-32(22)4)21-14(2)10-26-15(3)28-21/h5-12H,1-4H3,(H,29,34)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343321
PNG
((S)-4-(4,6-dimethylpyridin-2-yl)-N-(2-(3-fluoropyr...)
Show SMILES Cc1cc(C)nc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C22H23FN8O/c1-13-8-14(2)25-18(9-13)17-11-24-29(3)20(17)21(32)26-16-5-7-31-19(10-16)27-22(28-31)30-6-4-15(23)12-30/h5,7-11,15H,4,6,12H2,1-3H3,(H,26,32)/t15-/m0/s1
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343342
PNG
((S)-4-(4,6dimethylpyridin-2-yl)-N-(6-fluoro-2-(3-f...)
Show SMILES Cc1cc(C)nc(c1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)N1CC[C@H](F)C1
Show InChI InChI=1S/C22H22F2N8O/c1-12-6-13(2)26-17(7-12)15-9-25-30(3)20(15)21(33)27-18-8-19-28-22(29-32(19)11-16(18)24)31-5-4-14(23)10-31/h6-9,11,14H,4-5,10H2,1-3H3,(H,27,33)/t14-/m0/s1
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343347
PNG
(1-methyl-4-(6-methylpyrazin-2-yl)-N-(2-(pyrrolidin...)
Show SMILES Cc1cncc(n1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C20H21N9O/c1-13-10-21-12-16(23-13)15-11-22-27(2)18(15)19(30)24-14-5-8-29-17(9-14)25-20(26-29)28-6-3-4-7-28/h5,8-12H,3-4,6-7H2,1-2H3,(H,24,30)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343383
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-1-meth...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H18ClF2N7OS/c1-30-16(13(10-25-30)21-28-15(18(23)24)17(22)33-21)20(32)26-12-7-8-31-14(9-12)27-19(29-31)11-5-3-2-4-6-11/h2-6,10,12,18H,7-9H2,1H3,(H,26,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343388
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(2-methoxy...)
Show SMILES COc1ccccc1-c1nc2CC(CCn2n1)NC(=O)c1c(cnn1C)-c1nc(cs1)C(F)F
Show InChI InChI=1S/C22H21F2N7O2S/c1-30-18(14(10-25-30)22-27-15(11-34-22)19(23)24)21(32)26-12-7-8-31-17(9-12)28-20(29-31)13-5-3-4-6-16(13)33-2/h3-6,10-12,19H,7-9H2,1-2H3,(H,26,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343249
PNG
(1-methyl-4-(6-methylpyrazin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1cncc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-11-24-13-19(26-15)18-12-25-29(2)22(18)23(31)27-17-8-9-30-14-20(28-21(30)10-17)16-6-4-3-5-7-16/h3-7,11-14,17H,8-10H2,1-2H3,(H,27,31)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343265
PNG
(N-(2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H18F4N6OS/c1-31-19(15(9-27-31)21-30-17(11-34-21)22(24,25)26)20(33)28-14-6-7-32-10-16(29-18(32)8-14)12-2-4-13(23)5-3-12/h2-5,9-11,14H,6-8H2,1H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343272
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1cccnc1-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H18FN7O2/c1-30-21(15(12-26-30)20-18(33-2)9-6-10-25-20)23(32)27-17-11-19-28-22(14-7-4-3-5-8-14)29-31(19)13-16(17)24/h3-13H,1-2H3,(H,27,32)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343276
PNG
(4-(4,6-dimethylpyridin-2-yl)-N-(6-fluoro-2-phenyl-...)
Show SMILES Cc1cc(C)nc(c1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C24H20FN7O/c1-14-9-15(2)27-19(10-14)17-12-26-31(3)22(17)24(33)28-20-11-21-29-23(16-7-5-4-6-8-16)30-32(21)13-18(20)25/h4-13H,1-3H3,(H,28,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343287
PNG
(4-(2,5-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-pheny...)
Show SMILES Cc1ncc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O/c1-13-10-25-14(2)27-20(13)16-11-26-31(3)21(16)23(33)28-18-9-19-29-22(15-7-5-4-6-8-15)30-32(19)12-17(18)24/h4-12H,1-3H3,(H,28,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343318
PNG
(4-(4,6-dimethylpyridin-2-yl)-N-(6-fluoro-2-phenyl-...)
Show SMILES Cc1cc(C)nc(c1)-c1cn[nH]c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343335
PNG
((S)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES Cc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C21H21FN8O/c1-13-3-6-23-17(9-13)16-11-24-28(2)19(16)20(31)25-15-5-8-30-18(10-15)26-21(27-30)29-7-4-14(22)12-29/h3,5-6,8-11,14H,4,7,12H2,1-2H3,(H,25,31)/t14-/m0/s1
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343337
PNG
((S)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES Cc1cncc(n1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C20H20FN9O/c1-12-8-22-10-16(24-12)15-9-23-28(2)18(15)19(31)25-14-4-6-30-17(7-14)26-20(27-30)29-5-3-13(21)11-29/h4,6-10,13H,3,5,11H2,1-2H3,(H,25,31)/t13-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343230
PNG
(1-methyl-4-(5-methylpyridin-2-yl)-N-(2-phenylimida...)
Show SMILES Cc1ccc(nc1)-c1cnn(C)c1C(=O)Nc1ccn2cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C24H20N6O/c1-16-8-9-20(25-13-16)19-14-26-29(2)23(19)24(31)27-18-10-11-30-15-21(28-22(30)12-18)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,27,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343238
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(3-fluorop...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2cc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C22H19F3N6OS/c1-30-19(15(9-26-30)22-29-17(11-33-22)20(24)25)21(32)27-14-5-6-31-10-16(28-18(31)8-14)12-3-2-4-13(23)7-12/h2-4,7,9-11,14,20H,5-6,8H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343241
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-1-meth...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H19ClF2N6OS/c1-30-18(14(10-26-30)22-29-17(20(24)25)19(23)33-22)21(32)27-13-7-8-31-11-15(28-16(31)9-13)12-5-3-2-4-6-12/h2-6,10-11,13,20H,7-9H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343242
PNG
(4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-1-meth...)
Show SMILES Cc1sc(nc1C(F)F)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H22F2N6OS/c1-13-19(21(24)25)29-23(33-13)16-11-26-30(2)20(16)22(32)27-15-8-9-31-12-17(28-18(31)10-15)14-6-4-3-5-7-14/h3-7,11-12,15,21H,8-10H2,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343277
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(6-fluoro-2-p...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C21H14F3N7OS/c1-30-17(12(8-25-30)21-27-15(10-33-21)18(23)24)20(32)26-14-7-16-28-19(11-5-3-2-4-6-11)29-31(16)9-13(14)22/h2-10,18H,1H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343290
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1nccc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-24-9-8-17(26-13)15-11-25-30(2)20(15)22(32)27-18-10-19-28-21(14-6-4-3-5-7-14)29-31(19)12-16(18)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343303
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1ncnc(-c2cnn(C)c2C(=O)Nc2cc3nc(nn3cc2F)-c2ccccc2)c1F
Show InChI InChI=1S/C22H16F2N8O/c1-12-18(24)19(26-11-25-12)14-9-27-31(2)20(14)22(33)28-16-8-17-29-21(13-6-4-3-5-7-13)30-32(17)10-15(16)23/h3-11H,1-2H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343269
PNG
(4-(2,6-dimethoxypyrimidin-4-yl)-N-(6-fluoro-2-phen...)
Show SMILES COc1cc(nc(OC)n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O3/c1-31-20(14(11-25-31)16-10-19(34-2)29-23(27-16)35-3)22(33)26-17-9-18-28-21(13-7-5-4-6-8-13)30-32(18)12-15(17)24/h4-12H,1-3H3,(H,26,33)
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n/an/a<5n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343313
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cn1cnc(c1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C21H17FN8O/c1-28-11-17(23-12-28)14-9-24-29(2)19(14)21(31)25-16-8-18-26-20(13-6-4-3-5-7-13)27-30(18)10-15(16)22/h3-12H,1-2H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343316
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1ccc(nc1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H18FN7O/c1-14-8-9-18(25-11-14)16-12-26-30(2)21(16)23(32)27-19-10-20-28-22(15-6-4-3-5-7-15)29-31(20)13-17(19)24/h3-13H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343328
PNG
((S)-4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-1-...)
Show SMILES C[C@H]1CCCN1c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(C(F)F)c(C)s3)ccn2n1
Show InChI InChI=1S/C21H22F2N8OS/c1-11-5-4-7-30(11)21-26-15-9-13(6-8-31(15)28-21)25-19(32)17-14(10-24-29(17)3)20-27-16(18(22)23)12(2)33-20/h6,8-11,18H,4-5,7H2,1-3H3,(H,25,32)/t11-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343332
PNG
((R)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)(F)F)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@@H](F)C1
Show InChI InChI=1S/C19H16F4N8OS/c1-29-15(12(7-24-29)17-26-13(9-33-17)19(21,22)23)16(32)25-11-3-5-31-14(6-11)27-18(28-31)30-4-2-10(20)8-30/h3,5-7,9-10H,2,4,8H2,1H3,(H,25,32)/t10-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343279
PNG
(4-(3,6-dimethyl-pyrazin-2-yl)-N-(6-fluoro-2-phenyl...)
Show SMILES Cc1cnc(C)c(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O/c1-13-10-25-14(2)20(27-13)16-11-26-31(3)21(16)23(33)28-18-9-19-29-22(15-7-5-4-6-8-15)30-32(19)12-17(18)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343334
PNG
((S)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES Cn1ncc(c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C21H18F4N8O/c1-31-18(14(10-26-31)15-3-2-4-16(28-15)21(23,24)25)19(34)27-13-6-8-33-17(9-13)29-20(30-33)32-7-5-12(22)11-32/h2-4,6,8-10,12H,5,7,11H2,1H3,(H,27,34)/t12-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343339
PNG
((S)-N-(2-(3-fluoropyrrolidin-1-yl)-[1,2,4]triazolo...)
Show SMILES Cc1cccc(n1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@H](F)C1
Show InChI InChI=1S/C21H21FN8O/c1-13-4-3-5-17(24-13)16-11-23-28(2)19(16)20(31)25-15-7-9-30-18(10-15)26-21(27-30)29-8-6-14(22)12-29/h3-5,7,9-11,14H,6,8,12H2,1-2H3,(H,25,31)/t14-/m0/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343344
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-1-meth...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C19H17ClF2N8OS/c1-28-14(11(9-23-28)18-26-13(16(21)22)15(20)32-18)17(31)24-10-4-7-30-12(8-10)25-19(27-30)29-5-2-3-6-29/h4,7-9,16H,2-3,5-6H2,1H3,(H,24,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343346
PNG
(4-(4-methoxypyridin-2-yl)-1-methyl-N-(2-(pyrrolidi...)
Show SMILES COc1ccnc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C21H22N8O2/c1-27-19(16(13-23-27)17-12-15(31-2)5-7-22-17)20(30)24-14-6-10-29-18(11-14)25-21(26-29)28-8-3-4-9-28/h5-7,10-13H,3-4,8-9H2,1-2H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343349
PNG
(1-methyl-4-(6-methylpyridin-2-yl)-N-(2-(pyrrolidin...)
Show SMILES Cc1cccc(n1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C21H22N8O/c1-14-6-5-7-17(23-14)16-13-22-27(2)19(16)20(30)24-15-8-11-29-18(12-15)25-21(26-29)28-9-3-4-10-28/h5-8,11-13H,3-4,9-10H2,1-2H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343355
PNG
(4-(4-cyanothiazol-2-yl)-1-methyl-N-(2-phenyl-5,6,7...)
Show SMILES Cn1ncc(-c2nc(cs2)C#N)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H18N8OS/c1-28-18(16(11-23-28)21-25-15(10-22)12-31-21)20(30)24-14-7-8-29-17(9-14)26-19(27-29)13-5-3-2-4-6-13/h2-6,11-12,14H,7-9H2,1H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343358
PNG
(4-(6-cyanopyridin-2-yl)-1-methyl-N-(2-phenyl-5,6,7...)
Show SMILES Cn1ncc(c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1)-c1cccc(n1)C#N
Show InChI InChI=1S/C23H20N8O/c1-30-21(18(14-25-30)19-9-5-8-17(13-24)26-19)23(32)27-16-10-11-31-20(12-16)28-22(29-31)15-6-3-2-4-7-15/h2-9,14,16H,10-12H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343247
PNG
(4-(6-methoxypyridin-2-yl)-1-methyl-N-(2-phenyl-5,6...)
Show SMILES COc1cccc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O2/c1-29-23(18(14-25-29)19-9-6-10-22(28-19)32-2)24(31)26-17-11-12-30-15-20(27-21(30)13-17)16-7-4-3-5-8-16/h3-10,14-15,17H,11-13H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343248
PNG
(1-methyl-4-(2-methylthiazol-4-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1nc(cs1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H22N6OS/c1-14-24-19(13-30-14)17-11-23-27(2)21(17)22(29)25-16-8-9-28-12-18(26-20(28)10-16)15-6-4-3-5-7-15/h3-7,11-13,16H,8-10H2,1-2H3,(H,25,29)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343258
PNG
(1-methyl-4-(4-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1ccnc(c1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O/c1-16-8-10-25-20(12-16)19-14-26-29(2)23(19)24(31)27-18-9-11-30-15-21(28-22(30)13-18)17-6-4-3-5-7-17/h3-8,10,12,14-15,18H,9,11,13H2,1-2H3,(H,27,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343274
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1cncc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-9-24-11-18(26-13)15-10-25-30(2)20(15)22(32)27-17-8-19-28-21(14-6-4-3-5-7-14)29-31(19)12-16(17)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343284
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-((2S,6R)-2...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(cs3)C(F)F)ccn2n1
Show InChI InChI=1S/C21H22F2N8O2S/c1-11-8-30(9-12(2)33-11)21-27-16-6-13(4-5-31(16)28-21)25-19(32)17-14(7-24-29(17)3)20-26-15(10-34-20)18(22)23/h4-7,10-12,18H,8-9H2,1-3H3,(H,25,32)/t11-,12+
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343289
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1ccnnc1-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-8-9-24-28-19(13)15-11-25-30(2)20(15)22(32)26-17-10-18-27-21(14-6-4-3-5-7-14)29-31(18)12-16(17)23/h3-12H,1-2H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343293
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES COc1nccnc1-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O2/c1-30-19(14(11-26-30)18-22(33-2)25-9-8-24-18)21(32)27-16-10-17-28-20(13-6-4-3-5-7-13)29-31(17)12-15(16)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343294
PNG
(4-(5-chloropyrimidin-4-yl)-N-(6-fluoro-2-phenyl-[1...)
Show SMILES Cn1ncc(c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1)-c1ncncc1Cl
Show InChI InChI=1S/C21H14ClFN8O/c1-30-19(13(8-26-30)18-14(22)9-24-11-25-18)21(32)27-16-7-17-28-20(12-5-3-2-4-6-12)29-31(17)10-15(16)23/h2-11H,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343268
PNG
(4-(2,6-dimethylpyrimidin-4-yl)-N-(6-fluoro-2-pheny...)
Show SMILES Cc1cc(nc(C)n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O/c1-13-9-18(27-14(2)26-13)16-11-25-31(3)21(16)23(33)28-19-10-20-29-22(15-7-5-4-6-8-15)30-32(20)12-17(19)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343298
PNG
(N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin...)
Show SMILES Cc1cncnc1-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C22H17FN8O/c1-13-9-24-12-25-19(13)15-10-26-30(2)20(15)22(32)27-17-8-18-28-21(14-6-4-3-5-7-14)29-31(18)11-16(17)23/h3-12H,1-2H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343309
PNG
(4-(4,6-dimethylpyrimidin-2-yl)-N-(6-fluoro-2-pheny...)
Show SMILES Cc1cc(C)nc(n1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccccc1
Show InChI InChI=1S/C23H19FN8O/c1-13-9-14(2)27-22(26-13)16-11-25-31(3)20(16)23(33)28-18-10-19-29-21(15-7-5-4-6-8-15)30-32(19)12-17(18)24/h4-12H,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343319
PNG
(4-(4,6-dimethylpyridin-2-yl)-N-(6-fluoro-2-(4-fluo...)
Show SMILES Cc1cc(C)nc(c1)-c1cnn(C)c1C(=O)Nc1cc2nc(nn2cc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C24H19F2N7O/c1-13-8-14(2)28-19(9-13)17-11-27-32(3)22(17)24(34)29-20-10-21-30-23(31-33(21)12-18(20)26)15-4-6-16(25)7-5-15/h4-12H,1-3H3,(H,29,34)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343331
PNG
((R)-4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(3-flu...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)Nc1ccn2nc(nc2c1)N1CC[C@@H](F)C1
Show InChI InChI=1S/C19H17F3N8OS/c1-28-15(12(7-23-28)18-25-13(9-32-18)16(21)22)17(31)24-11-3-5-30-14(6-11)26-19(27-30)29-4-2-10(20)8-29/h3,5-7,9-10,16H,2,4,8H2,1H3,(H,24,31)/t10-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343350
PNG
(4-(4,6-dimethylpyridin-2-yl)-1-methyl-N-(2-(pyrrol...)
Show SMILES Cc1cc(C)nc(c1)-c1cnn(C)c1C(=O)Nc1ccn2nc(nc2c1)N1CCCC1
Show InChI InChI=1S/C22H24N8O/c1-14-10-15(2)24-18(11-14)17-13-23-28(3)20(17)21(31)25-16-6-9-30-19(12-16)26-22(27-30)29-7-4-5-8-29/h6,9-13H,4-5,7-8H2,1-3H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343390
PNG
(4-(4-(difluoromethyl)-5-methylthiazol-2-yl)-N-(2-(...)
Show SMILES Cc1sc(nc1C(F)F)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20F3N7OS/c1-11-17(19(24)25)29-22(34-11)15-10-26-31(2)18(15)21(33)27-14-7-8-32-16(9-14)28-20(30-32)12-3-5-13(23)6-4-12/h3-6,10,14,19H,7-9H2,1-2H3,(H,27,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343252
PNG
(1-methyl-4-(4-methylpyrimidin-2-yl)-N-(2-phenyl-5,...)
Show SMILES Cc1ccnc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-8-10-24-22(26-15)18-13-25-29(2)21(18)23(31)27-17-9-11-30-14-19(28-20(30)12-17)16-6-4-3-5-7-16/h3-8,10,13-14,17H,9,11-12H2,1-2H3,(H,27,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343401
PNG
(1-methyl-4-(6-methylpyridin-2-yl)-N-(2-(pyrrolidin...)
Show SMILES Cc1cccc(n1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)N1CCCC1
Show InChI InChI=1S/C21H26N8O/c1-14-6-5-7-17(23-14)16-13-22-27(2)19(16)20(30)24-15-8-11-29-18(12-15)25-21(26-29)28-9-3-4-10-28/h5-7,13,15H,3-4,8-12H2,1-2H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343363
PNG
((1-methyl-N-(2-phenyl-5,6,7,8-tetrahydro-[1,2,4]tr...)
Show SMILES CS1C=C(N(C1n1nccc1C(N)=O)C1CCn2nc(nc2C1)-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N7OS/c1-33-12-16(21(22,23)24)30(20(33)31-15(18(25)32)7-9-26-31)14-8-10-29-17(11-14)27-19(28-29)13-5-3-2-4-6-13/h2-7,9,12,14,20H,8,10-11H2,1H3,(H2,25,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343365
PNG
(4-(5-(2-ethoxyethyl)-4-methylthiazol-2-yl)-1-methy...)
Show SMILES CCOCCc1sc(nc1C)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C25H29N7O2S/c1-4-34-13-11-20-16(2)27-25(35-20)19-15-26-31(3)22(19)24(33)28-18-10-12-32-21(14-18)29-23(30-32)17-8-6-5-7-9-17/h5-9,15,18H,4,10-14H2,1-3H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343366
PNG
(4-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-methyl-N-(2-ph...)
Show SMILES CCc1nnc(s1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H22N8OS/c1-3-17-25-26-21(31-17)15-12-22-28(2)18(15)20(30)23-14-9-10-29-16(11-14)24-19(27-29)13-7-5-4-6-8-13/h4-8,12,14H,3,9-11H2,1-2H3,(H,23,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343389
PNG
(4-(5-cyclopropyl-4-(difluoromethyl)thiazol-2-yl)-N...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(s2)C2CC2)c1C(=O)NC1CCn2nc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H22F3N7OS/c1-33-19(16(11-28-33)24-31-18(21(26)27)20(36-24)12-2-3-12)23(35)29-15-8-9-34-17(10-15)30-22(32-34)13-4-6-14(25)7-5-13/h4-7,11-12,15,21H,2-3,8-10H2,1H3,(H,29,35)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343393
PNG
(4-(2,5-dimethylthiazol-4-yl)-1-methyl-N-(2-phenyl-...)
Show SMILES Cc1nc(c(C)s1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H23N7OS/c1-13-19(24-14(2)31-13)17-12-23-28(3)20(17)22(30)25-16-9-10-29-18(11-16)26-21(27-29)15-7-5-4-6-8-15/h4-8,12,16H,9-11H2,1-3H3,(H,25,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343395
PNG
(4-(4-cyanothiazol-2-yl)-N-(2-(4-fluorophenyl)-5,6,...)
Show SMILES Cn1ncc(-c2nc(cs2)C#N)c1C(=O)NC1CCn2nc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN8OS/c1-29-18(16(10-24-29)21-26-15(9-23)11-32-21)20(31)25-14-6-7-30-17(8-14)27-19(28-30)12-2-4-13(22)5-3-12/h2-5,10-11,14H,6-8H2,1H3,(H,25,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343261
PNG
(1-methyl-N-(2-phenyl-5,6,7,8-tetrahydroimidazo[1,2...)
Show SMILES Cn1ncc(-c2cscn2)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H20N6OS/c1-26-20(16(10-23-26)18-12-29-13-22-18)21(28)24-15-7-8-27-11-17(25-19(27)9-15)14-5-3-2-4-6-14/h2-6,10-13,15H,7-9H2,1H3,(H,24,28)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343286
PNG
(N-(5-chloro-2-(2-methoxyphenyl)-[1,2,4]triazolo[1,...)
Show SMILES COc1ccccc1-c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(C(F)F)c(Cl)s3)cc(Cl)n2n1
Show InChI InChI=1S/C22H15Cl2F2N7O2S/c1-32-17(12(9-27-32)22-30-16(19(25)26)18(24)36-22)21(34)28-10-7-14(23)33-15(8-10)29-20(31-33)11-5-3-4-6-13(11)35-2/h3-9,19H,1-2H3,(H,28,34)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343354
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-N-(2-(...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc2cc(NC(=O)c3c(cnn3C)-c3nc(C(F)F)c(Cl)s3)ccn2n1
Show InChI InChI=1S/C21H21ClF2N8O2S/c1-10-8-31(9-11(2)34-10)21-27-14-6-12(4-5-32(14)29-21)26-19(33)16-13(7-25-30(16)3)20-28-15(18(23)24)17(22)35-20/h4-7,10-11,18H,8-9H2,1-3H3,(H,26,33)/t10-,11+
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n/an/a 52n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343398
PNG
(4-(5-acetyl-2-methylthiazol-4-yl)-N-(2-(3-fluoroph...)
Show SMILES CC(=O)c1sc(C)nc1-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22FN7O2S/c1-12(32)21-19(26-13(2)34-21)17-11-25-30(3)20(17)23(33)27-16-7-8-31-18(10-16)28-22(29-31)14-5-4-6-15(24)9-14/h4-6,9,11,16H,7-8,10H2,1-3H3,(H,27,33)
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n/an/a 52n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343254
PNG
(N-(2-(2,5-difluorophenyl)-5,6,7,8-tetrahydroimidaz...)
Show SMILES Cc1nnc(s1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1cc(F)ccc1F
Show InChI InChI=1S/C21H19F2N7OS/c1-11-27-28-21(32-11)15-9-24-29(2)19(15)20(31)25-13-5-6-30-10-17(26-18(30)8-13)14-7-12(22)3-4-16(14)23/h3-4,7,9-10,13H,5-6,8H2,1-2H3,(H,25,31)
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n/an/a 52n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343257
PNG
(1-methyl-4-(5-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1ccc(nc1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O/c1-16-8-9-20(25-13-16)19-14-26-29(2)23(19)24(31)27-18-10-11-30-15-21(28-22(30)12-18)17-6-4-3-5-7-17/h3-9,13-15,18H,10-12H2,1-2H3,(H,27,31)
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n/an/a 52n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343380
PNG
(1-methyl-4-(5-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1ccc(nc1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-8-9-19(24-13-15)18-14-25-29(2)21(18)23(31)26-17-10-11-30-20(12-17)27-22(28-30)16-6-4-3-5-7-16/h3-9,13-14,17H,10-12H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343392
PNG
(4-(5-cyclopropyl-4-methylthiazol-2-yl)-1-methyl-N-...)
Show SMILES Cc1nc(sc1C1CC1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C24H25N7OS/c1-14-21(15-8-9-15)33-24(26-14)18-13-25-30(2)20(18)23(32)27-17-10-11-31-19(12-17)28-22(29-31)16-6-4-3-5-7-16/h3-7,13,15,17H,8-12H2,1-2H3,(H,27,32)
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n/an/a 52n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343260
PNG
(N-(2-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,...)
Show SMILES Cc1cncc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22FN7O/c1-14-10-25-12-19(27-14)18-11-26-30(2)22(18)23(32)28-17-6-7-31-13-20(29-21(31)9-17)15-4-3-5-16(24)8-15/h3-5,8,10-13,17H,6-7,9H2,1-2H3,(H,28,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343372
PNG
(1-methyl-4-(4-methylthiazol-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1csc(n1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H21N7OS/c1-13-12-30-21(23-13)16-11-22-27(2)18(16)20(29)24-15-8-9-28-17(10-15)25-19(26-28)14-6-4-3-5-7-14/h3-7,11-12,15H,8-10H2,1-2H3,(H,24,29)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343378
PNG
(4-(5-fluoropyridin-2-yl)-1-methyl-N-(2-phenyl-5,6,...)
Show SMILES Cn1ncc(c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1)-c1ccc(F)cn1
Show InChI InChI=1S/C22H20FN7O/c1-29-20(17(13-25-29)18-8-7-15(23)12-24-18)22(31)26-16-9-10-30-19(11-16)27-21(28-30)14-5-3-2-4-6-14/h2-8,12-13,16H,9-11H2,1H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343357
PNG
(4-(5-acetyl-2-methylthiazol-4-yl)-1-methyl-N-(2-ph...)
Show SMILES CC(=O)c1sc(C)nc1-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O2S/c1-13(31)21-19(25-14(2)33-21)17-12-24-29(3)20(17)23(32)26-16-9-10-30-18(11-16)27-22(28-30)15-7-5-4-6-8-15/h4-8,12,16H,9-11H2,1-3H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343387
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(3-fluorop...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2nc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C21H18F3N7OS/c1-30-17(14(9-25-30)21-27-15(10-33-21)18(23)24)20(32)26-13-5-6-31-16(8-13)28-19(29-31)11-3-2-4-12(22)7-11/h2-4,7,9-10,13,18H,5-6,8H2,1H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343397
PNG
(4-(5-cyclopropyl-4-methylthiazol-2-yl)-N-(2-(4-flu...)
Show SMILES Cc1nc(sc1C1CC1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN7OS/c1-13-21(14-3-4-14)34-24(27-13)18-12-26-31(2)20(18)23(33)28-17-9-10-32-19(11-17)29-22(30-32)15-5-7-16(25)8-6-15/h5-8,12,14,17H,3-4,9-11H2,1-2H3,(H,28,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343362
PNG
(4-(5-cyclopropyl-4-(difluoromethyl)thiazol-2-yl)-1...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(s2)C2CC2)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C24H23F2N7OS/c1-32-19(16(12-27-32)24-30-18(21(25)26)20(35-24)13-7-8-13)23(34)28-15-9-10-33-17(11-15)29-22(31-33)14-5-3-2-4-6-14/h2-6,12-13,15,21H,7-11H2,1H3,(H,28,34)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343367
PNG
(4-(5-bromo-2-methylthiazol-4-yl)-1-methyl-N-(2-phe...)
Show SMILES Cc1nc(c(Br)s1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H20BrN7OS/c1-12-24-17(19(22)31-12)15-11-23-28(2)18(15)21(30)25-14-8-9-29-16(10-14)26-20(27-29)13-6-4-3-5-7-13/h3-7,11,14H,8-10H2,1-2H3,(H,25,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343370
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-((R)-2-(me...)
Show SMILES COC[C@H]1CCCN1c1nc2CC(CCn2n1)NC(=O)c1c(cnn1C)-c1nc(cs1)C(F)F
Show InChI InChI=1S/C21H26F2N8O2S/c1-29-17(14(9-24-29)20-26-15(11-34-20)18(22)23)19(32)25-12-5-7-31-16(8-12)27-21(28-31)30-6-3-4-13(30)10-33-2/h9,11-13,18H,3-8,10H2,1-2H3,(H,25,32)/t12?,13-/m1/s1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343376
PNG
(1-methyl-4-(3-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1cccnc1-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-7-6-11-24-20(15)18-14-25-29(2)21(18)23(31)26-17-10-12-30-19(13-17)27-22(28-30)16-8-4-3-5-9-16/h3-9,11,14,17H,10,12-13H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343381
PNG
(4-(3-cyanopyridin-2-yl)-1-methyl-N-(2-phenyl-5,6,7...)
Show SMILES Cn1ncc(c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1)-c1ncccc1C#N
Show InChI InChI=1S/C23H20N8O/c1-30-21(18(14-26-30)20-16(13-24)8-5-10-25-20)23(32)27-17-9-11-31-19(12-17)28-22(29-31)15-6-3-2-4-7-15/h2-8,10,14,17H,9,11-12H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343358
PNG
(4-(6-cyanopyridin-2-yl)-1-methyl-N-(2-phenyl-5,6,7...)
Show SMILES Cn1ncc(c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1)-c1cccc(n1)C#N
Show InChI InChI=1S/C23H20N8O/c1-30-21(18(14-25-30)19-9-5-8-17(13-24)26-19)23(32)27-16-10-11-31-20(12-16)28-22(29-31)15-6-3-2-4-7-15/h2-9,14,16H,10-12H2,1H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343262
PNG
(1-methyl-N-(2-phenyl-5,6,7,8-tetrahydroimidazo[1,2...)
Show SMILES Cn1ncc(-c2nccs2)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H20N6OS/c1-26-19(16(12-23-26)21-22-8-10-29-21)20(28)24-15-7-9-27-13-17(25-18(27)11-15)14-5-3-2-4-6-14/h2-6,8,10,12-13,15H,7,9,11H2,1H3,(H,24,28)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343356
PNG
(1-methyl-4-(4-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1ccnc(c1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-8-10-24-19(12-15)18-14-25-29(2)21(18)23(31)26-17-9-11-30-20(13-17)27-22(28-30)16-6-4-3-5-7-16/h3-8,10,12,14,17H,9,11,13H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343377
PNG
(4-(4-fluoropyridin-2-yl)-1-methyl-N-(2-phenyl-5,6,...)
Show SMILES Cn1ncc(c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1)-c1cc(F)ccn1
Show InChI InChI=1S/C22H20FN7O/c1-29-20(17(13-25-29)18-11-15(23)7-9-24-18)22(31)26-16-8-10-30-19(12-16)27-21(28-30)14-5-3-2-4-6-14/h2-7,9,11,13,16H,8,10,12H2,1H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343259
PNG
(N-(2-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,...)
Show SMILES Cc1ccnc(n1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22FN7O/c1-14-6-8-25-22(27-14)18-12-26-30(2)21(18)23(32)28-17-7-9-31-13-19(29-20(31)11-17)15-4-3-5-16(24)10-15/h3-6,8,10,12-13,17H,7,9,11H2,1-2H3,(H,28,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343263
PNG
(4-(4-(tert-butyl)thiazol-2-yl)-1-methyl-N-(2-pheny...)
Show SMILES Cn1ncc(-c2nc(cs2)C(C)(C)C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C25H28N6OS/c1-25(2,3)20-15-33-24(29-20)18-13-26-30(4)22(18)23(32)27-17-10-11-31-14-19(28-21(31)12-17)16-8-6-5-7-9-16/h5-9,13-15,17H,10-12H2,1-4H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343375
PNG
(1-methyl-N-(2-phenyl-5,6,7,8-tetrahydro-[1,2,4]tri...)
Show SMILES Cn1ncc(c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N7O/c1-32-20(16(13-27-32)17-8-5-9-18(29-17)23(24,25)26)22(34)28-15-10-11-33-19(12-15)30-21(31-33)14-6-3-2-4-7-14/h2-9,13,15H,10-12H2,1H3,(H,28,34)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343379
PNG
(4-(4-methoxypyridin-2-yl)-1-methyl-N-(2-phenyl-5,6...)
Show SMILES COc1ccnc(c1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O2/c1-29-21(18(14-25-29)19-13-17(32-2)8-10-24-19)23(31)26-16-9-11-30-20(12-16)27-22(28-30)15-6-4-3-5-7-15/h3-8,10,13-14,16H,9,11-12H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343385
PNG
(4-(5-(1-hydroxyethyl)-2-methylthiazol-4-yl)-1-meth...)
Show SMILES CC(O)c1sc(C)nc1-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H25N7O2S/c1-13(31)21-19(25-14(2)33-21)17-12-24-29(3)20(17)23(32)26-16-9-10-30-18(11-16)27-22(28-30)15-7-5-4-6-8-15/h4-8,12-13,16,31H,9-11H2,1-3H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343386
PNG
(4-(4-(difluoromethyl)thiazol-2-yl)-N-(2-(2-fluorop...)
Show SMILES Cn1ncc(-c2nc(cs2)C(F)F)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1F
Show InChI InChI=1S/C21H18F3N7OS/c1-30-17(13(9-25-30)21-27-15(10-33-21)18(23)24)20(32)26-11-6-7-31-16(8-11)28-19(29-31)12-4-2-3-5-14(12)22/h2-5,9-11,18H,6-8H2,1H3,(H,26,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343396
PNG
(4-(5-cyclopropyl-4-(difluoromethyl)thiazol-2-yl)-N...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(s2)C2CC2)c1C(=O)NC1CCn2nc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C24H22F3N7OS/c1-33-19(16(11-28-33)24-31-18(21(26)27)20(36-24)12-5-6-12)23(35)29-15-7-8-34-17(10-15)30-22(32-34)13-3-2-4-14(25)9-13/h2-4,9,11-12,15,21H,5-8,10H2,1H3,(H,29,35)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343253
PNG
(1-methyl-4-(1-methyl-1H-imidazol-4-yl)-N-(2-phenyl...)
Show SMILES Cn1cnc(c1)-c1cnn(C)c1C(=O)NC1CCn2cc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C22H23N7O/c1-27-12-19(23-14-27)17-11-24-28(2)21(17)22(30)25-16-8-9-29-13-18(26-20(29)10-16)15-6-4-3-5-7-15/h3-7,11-14,16H,8-10H2,1-2H3,(H,25,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343355
PNG
(4-(4-cyanothiazol-2-yl)-1-methyl-N-(2-phenyl-5,6,7...)
Show SMILES Cn1ncc(-c2nc(cs2)C#N)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C21H18N8OS/c1-28-18(16(11-23-28)21-25-15(10-22)12-31-21)20(30)24-14-7-8-29-17(9-14)26-19(27-29)13-5-3-2-4-6-13/h2-6,11-12,14H,7-9H2,1H3,(H,24,30)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343368
PNG
(4-(3,6-dimethylpyrazin-2-yl)-1-methyl-N-(2-phenyl-...)
Show SMILES Cc1cnc(C)c(n1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H24N8O/c1-14-12-24-15(2)20(26-14)18-13-25-30(3)21(18)23(32)27-17-9-10-31-19(11-17)28-22(29-31)16-7-5-4-6-8-16/h4-8,12-13,17H,9-11H2,1-3H3,(H,27,32)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343369
PNG
(1-methyl-4-(3-methyl-1,2,4-thiadiazol-5-yl)-N-(2-p...)
Show SMILES Cc1nsc(n1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C20H20N8OS/c1-12-22-20(30-26-12)15-11-21-27(2)17(15)19(29)23-14-8-9-28-16(10-14)24-18(25-28)13-6-4-3-5-7-13/h3-7,11,14H,8-10H2,1-2H3,(H,23,29)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343373
PNG
(1-methyl-4-(6-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1cccc(n1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-7-6-10-19(25-15)18-14-24-29(2)21(18)23(31)26-17-11-12-30-20(13-17)27-22(28-30)16-8-4-3-5-9-16/h3-10,14,17H,11-13H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343382
PNG
(4-(2,5-dimethylthiazol-4-yl)-N-(2-(4-fluorophenyl)...)
Show SMILES Cc1nc(c(C)s1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FN7OS/c1-12-19(25-13(2)32-12)17-11-24-29(3)20(17)22(31)26-16-8-9-30-18(10-16)27-21(28-30)14-4-6-15(23)7-5-14/h4-7,11,16H,8-10H2,1-3H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343391
PNG
(4-(5-chloro-4-(difluoromethyl)thiazol-2-yl)-N-(2-(...)
Show SMILES Cn1ncc(-c2nc(C(F)F)c(Cl)s2)c1C(=O)NC1CCn2nc(nc2C1)-c1cccc(F)c1
Show InChI InChI=1S/C21H17ClF3N7OS/c1-31-16(13(9-26-31)21-29-15(18(24)25)17(22)34-21)20(33)27-12-5-6-32-14(8-12)28-19(30-32)10-3-2-4-11(23)7-10/h2-4,7,9,12,18H,5-6,8H2,1H3,(H,27,33)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase (PDE10)


(Homo sapiens (Human))
BDBM343356
PNG
(1-methyl-4-(4-methylpyridin-2-yl)-N-(2-phenyl-5,6,...)
Show SMILES Cc1ccnc(c1)-c1cnn(C)c1C(=O)NC1CCn2nc(nc2C1)-c1ccccc1
Show InChI InChI=1S/C23H23N7O/c1-15-8-10-24-19(12-15)18-14-25-29(2)21(18)23(31)26-17-9-11-30-20(13-17)27-22(28-30)16-6-4-3-5-7-16/h3-8,10,12,14,17H,9,11,13H2,1-2H3,(H,26,31)
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IMAP TR-FRET Phosphodiersterase Evaluation Assay Kit (Molecular Device) was used for the measurement. Ten μL of a diluted test compound having e...


US Patent US9777000 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%