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Patent code US9777008

Compile Data Set for Download or QSAR

Found 310 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343886
PNG
(US9777008, Compound 180)
Show SMILES COC(=O)c1cncc(c1)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H26N2O4/c1-30-25(29)22-11-21(13-26-14-22)19-7-4-8-24(12-19)31-17-23(28)16-27-10-9-18-5-2-3-6-20(18)15-27/h2-8,11-14,23,28H,9-10,15-17H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343890
PNG
(US9777008, Compound 184)
Show SMILES OC(COc1cccc(NC(=O)c2ccnnc2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H24N4O3/c28-21(15-27-11-9-17-4-1-2-5-19(17)14-27)16-30-22-7-3-6-20(12-22)26-23(29)18-8-10-24-25-13-18/h1-8,10,12-13,21,28H,9,11,14-16H2,(H,26,29)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343901
PNG
(US9777008, Compound 195)
Show SMILES Cn1cncc1C(=O)Nc1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C23H26N4O3/c1-26-16-24-12-22(26)23(29)25-19-7-4-8-21(11-19)30-15-20(28)14-27-10-9-17-5-2-3-6-18(17)13-27/h2-8,11-12,16,20,28H,9-10,13-15H2,1H3,(H,25,29)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343920
PNG
(US9777008, Compound 214)
Show SMILES Cn1cnc2ccc(cc12)-c1cccc(OCC(O)CN2CCc3ccc(Cl)cc3C2)c1
Show InChI InChI=1S/C26H26ClN3O2/c1-29-17-28-25-8-6-20(13-26(25)29)19-3-2-4-24(12-19)32-16-23(31)15-30-10-9-18-5-7-22(27)11-21(18)14-30/h2-8,11-13,17,23,31H,9-10,14-16H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343930
PNG
(US9777008, Compound 224)
Show SMILES Cn1cc2ccc(cc2n1)-c1cc(NCC(O)CN2CCc3ccccc3C2)ncn1
Show InChI InChI=1S/C24H26N6O/c1-29-13-20-7-6-18(10-23(20)28-29)22-11-24(27-16-26-22)25-12-21(31)15-30-9-8-17-4-2-3-5-19(17)14-30/h2-7,10-11,13,16,21,31H,8-9,12,14-15H2,1H3,(H,25,26,27)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343935
PNG
(US9777008, Compound 229)
Show SMILES OC(CNc1cc(ccn1)-c1ccc2ncn(C3CNC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C27H30N6O/c34-24(17-32-10-8-19-3-1-2-4-22(19)16-32)15-30-27-12-21(7-9-29-27)20-5-6-25-26(11-20)33(18-31-25)23-13-28-14-23/h1-7,9,11-12,18,23-24,28,34H,8,10,13-17H2,(H,29,30)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343937
PNG
(US9777008, Compound 231)
Show SMILES OC(COc1cccc(c1)-c1ncc2ccn(CC(=O)N3CCCC3)c2n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C30H33N5O3/c36-26(19-33-14-10-22-6-1-2-7-25(22)18-33)21-38-27-9-5-8-23(16-27)29-31-17-24-11-15-35(30(24)32-29)20-28(37)34-12-3-4-13-34/h1-2,5-9,11,15-17,26,36H,3-4,10,12-14,18-21H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343941
PNG
(US9777008, Compound 235)
Show SMILES OC(CNc1cccc(c1)-c1cccc2[nH]cnc12)CN1CCc2ccccc2C1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343955
PNG
(US9777008, Compound 249)
Show SMILES OC(COc1cccc(c1)-c1ccc2ncn(CC(=O)N3CCCCC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C32H36N4O3/c37-28(20-34-16-13-24-7-2-3-8-27(24)19-34)22-39-29-10-6-9-25(17-29)26-11-12-30-31(18-26)36(23-33-30)21-32(38)35-14-4-1-5-15-35/h2-3,6-12,17-18,23,28,37H,1,4-5,13-16,19-22H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343963
PNG
((R)-1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(quin...)
Show SMILES O[C@@H](COc1cccc(c1)-c1cccc2cccnc12)CN1CCc2ccccc2C1
Show InChI InChI=1S/C27H26N2O2/c30-24(18-29-15-13-20-6-1-2-7-23(20)17-29)19-31-25-11-3-9-22(16-25)26-12-4-8-21-10-5-14-28-27(21)26/h1-12,14,16,24,30H,13,15,17-19H2/t24-/m1/s1
PDB

UniProtKB/SwissProt

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DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343974
PNG
(US9777008, Compound 268)
Show SMILES OC(COc1cccc(c1)C(=O)Nc1cccnc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H25N3O3/c28-22(16-27-12-10-18-5-1-2-6-20(18)15-27)17-30-23-9-3-7-19(13-23)24(29)26-21-8-4-11-25-14-21/h1-9,11,13-14,22,28H,10,12,15-17H2,(H,26,29)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM344010
PNG
(US9777008, Compound 304)
Show SMILES OC(COCC1CCCCO1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C18H27NO3/c20-17(13-21-14-18-7-3-4-10-22-18)12-19-9-8-15-5-1-2-6-16(15)11-19/h1-2,5-6,17-18,20H,3-4,7-14H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>4.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM344016
PNG
(US9777008, Compound 310)
Show SMILES OC(COC1CCOCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C17H25NO3/c19-16(13-21-17-6-9-20-10-7-17)12-18-8-5-14-3-1-2-4-15(14)11-18/h1-4,16-17,19H,5-13H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.50E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343715
PNG
(US9777008, Compound 9)
Show SMILES OC(COc1ccc(cc1)-n1cncn1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C20H22N4O2/c25-19(12-23-10-9-16-3-1-2-4-17(16)11-23)13-26-20-7-5-18(6-8-20)24-15-21-14-22-24/h1-8,14-15,19,25H,9-13H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343725
PNG
(US9777008, Compound 19)
Show SMILES OC(COc1ccc(OCc2ccccc2)cc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H27NO3/c27-23(17-26-15-14-21-8-4-5-9-22(21)16-26)19-29-25-12-10-24(11-13-25)28-18-20-6-2-1-3-7-20/h1-13,23,27H,14-19H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343740
PNG
(US9777008, Compound 34)
Show SMILES OC(COc1ccc(cc1)-c1ccn(Cc2ccc(cc2)C(=O)N2CCCC2)n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C33H36N4O3/c38-30(23-35-19-15-26-5-1-2-6-29(26)22-35)24-40-31-13-11-27(12-14-31)32-16-20-37(34-32)21-25-7-9-28(10-8-25)33(39)36-17-3-4-18-36/h1-2,5-14,16,20,30,38H,3-4,15,17-19,21-24H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343752
PNG
(US9777008, Compound 46)
Show SMILES OC(COCc1ccc(CN2CCOCC2)cc1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H32N2O3/c27-24(17-26-10-9-22-3-1-2-4-23(22)16-26)19-29-18-21-7-5-20(6-8-21)15-25-11-13-28-14-12-25/h1-8,24,27H,9-19H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343753
PNG
(US9777008, Compound 47)
Show SMILES OC(COc1ccc(cc1)C1CCCNC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H30N2O2/c26-22(16-25-13-11-18-4-1-2-5-21(18)15-25)17-27-23-9-7-19(8-10-23)20-6-3-12-24-14-20/h1-2,4-5,7-10,20,22,24,26H,3,6,11-17H2
PDB

UniProtKB/SwissProt

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DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343757
PNG
(US9777008, Compound 51)
Show SMILES CC1Cc2ccccc2CN1CC(O)COc1cccc(CNC2CCCC2)c1
Show InChI InChI=1S/C25H34N2O2/c1-19-13-21-8-2-3-9-22(21)16-27(19)17-24(28)18-29-25-12-6-7-20(14-25)15-26-23-10-4-5-11-23/h2-3,6-9,12,14,19,23-24,26,28H,4-5,10-11,13,15-18H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>4.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343763
PNG
(US9777008, Compound 57)
Show SMILES OC(COc1cccc(c1)C1=CCCCC1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H29NO2/c26-23(17-25-14-13-20-9-4-5-10-22(20)16-25)18-27-24-12-6-11-21(15-24)19-7-2-1-3-8-19/h4-7,9-12,15,23,26H,1-3,8,13-14,16-18H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343772
PNG
(US9777008, Compound 66)
Show SMILES Cn1cnc2ccc(cc12)N1CCCC(C1)OCC(O)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H32N4O2/c1-27-18-26-24-9-8-21(13-25(24)27)29-11-4-7-23(16-29)31-17-22(30)15-28-12-10-19-5-2-3-6-20(19)14-28/h2-3,5-6,8-9,13,18,22-23,30H,4,7,10-12,14-17H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343776
PNG
(US9777008, Compound 70)
Show SMILES OC(COc1cccc(c1)-c1ccc(O)c(F)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H24FNO3/c25-23-13-19(8-9-24(23)28)18-6-3-7-22(12-18)29-16-21(27)15-26-11-10-17-4-1-2-5-20(17)14-26/h1-9,12-13,21,27-28H,10-11,14-16H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343780
PNG
(US9777008, Compound 74)
Show SMILES COc1cccc(c1)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H27NO3/c1-28-24-10-4-8-20(14-24)21-9-5-11-25(15-21)29-18-23(27)17-26-13-12-19-6-2-3-7-22(19)16-26/h2-11,14-15,23,27H,12-13,16-18H2,1H3
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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343786
PNG
(US9777008, Compound 80)
Show SMILES CC1N(CC(O)COc2cccc(c2)-c2ccc3ncn(C)c3c2)CCc2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-25-9-4-3-6-20(25)12-13-30(19)16-23(31)17-32-24-8-5-7-21(14-24)22-10-11-26-27(15-22)29(2)18-28-26/h3-11,14-15,18-19,23,31H,12-13,16-17H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343788
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(4-met...)
Show SMILES COc1ccc(Cn2cnc3ccc(cc23)-c2cccc(OCC(O)CN3CCc4ccccc4C3)c2)cc1
Show InChI InChI=1S/C33H33N3O3/c1-38-30-12-9-24(10-13-30)19-36-23-34-32-14-11-27(18-33(32)36)26-7-4-8-31(17-26)39-22-29(37)21-35-16-15-25-5-2-3-6-28(25)20-35/h2-14,17-18,23,29,37H,15-16,19-22H2,1H3
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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343796
PNG
(US9777008, Compound 90)
Show SMILES COc1ccc(c(C)c1)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C26H29NO3/c1-19-14-24(29-2)10-11-26(19)21-8-5-9-25(15-21)30-18-23(28)17-27-13-12-20-6-3-4-7-22(20)16-27/h3-11,14-15,23,28H,12-13,16-18H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343798
PNG
(US9777008, Compound 92)
Show SMILES OC(COc1cccc(c1)-c1ccccc1Cl)CN1CCc2ccccc2C1
Show InChI InChI=1S/C24H24ClNO2/c25-24-11-4-3-10-23(24)19-8-5-9-22(14-19)28-17-21(27)16-26-13-12-18-6-1-2-7-20(18)15-26/h1-11,14,21,27H,12-13,15-17H2
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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343809
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(tetra...)
Show SMILES OC(COc1cccc(c1)-c1ccc2ncn(C3CCOCC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C30H33N3O3/c34-27(19-32-13-10-22-4-1-2-5-25(22)18-32)20-36-28-7-3-6-23(16-28)24-8-9-29-30(17-24)33(21-31-29)26-11-14-35-15-12-26/h1-9,16-17,21,26-27,34H,10-15,18-20H2
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343815
PNG
(5-(3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydrox...)
Show SMILES OC(COc1cccc(c1)-c1ccc2[nH]c(=O)[nH]c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H23N3O3/c29-21(15-28-11-10-17-4-1-2-5-20(17)14-28)16-31-22-7-3-6-18(12-22)19-8-9-23-24(13-19)27-25(30)26-23/h1-9,12-13,21,29H,10-11,14-16H2
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343824
PNG
(1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((4-(1-methy...)
Show SMILES Cn1cnc2ccc(cc12)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H27N5O/c1-29-17-28-23-7-6-19(12-24(23)29)20-8-10-26-25(13-20)27-14-22(31)16-30-11-9-18-4-2-3-5-21(18)15-30/h2-8,10,12-13,17,22,31H,9,11,14-16H2,1H3,(H,26,27)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343819
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-methyl...)
Show SMILES Cc1ccncc1-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C24H26N2O2/c1-18-9-11-25-14-24(18)20-7-4-8-23(13-20)28-17-22(27)16-26-12-10-19-5-2-3-6-21(19)15-26/h2-9,11,13-14,22,27H,10,12,15-17H2,1H3
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343843
PNG
(US9777008, Compound 137)
Show SMILES CC(=O)c1ccc(cc1)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C26H27NO3/c1-19(28)20-9-11-22(12-10-20)23-7-4-8-26(15-23)30-18-25(29)17-27-14-13-21-5-2-3-6-24(21)16-27/h2-12,15,25,29H,13-14,16-18H2,1H3
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343847
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(7-methyl...)
Show SMILES Cn1ccc2cnc(nc12)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H26N4O2/c1-28-11-9-20-14-26-24(27-25(20)28)19-7-4-8-23(13-19)31-17-22(30)16-29-12-10-18-5-2-3-6-21(18)15-29/h2-9,11,13-14,22,30H,10,12,15-17H2,1H3
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343853
PNG
(US9777008, Compound 147)
Show SMILES Cn1ccc2ccc(cc12)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C27H28N2O2/c1-28-13-11-21-9-10-23(16-27(21)28)22-7-4-8-26(15-22)31-19-25(30)18-29-14-12-20-5-2-3-6-24(20)17-29/h2-11,13,15-16,25,30H,12,14,17-19H2,1H3
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343856
PNG
(US9777008, Compound 150)
Show SMILES CC(C)(C)OCc1cccc(c1)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C29H35NO3/c1-29(2,3)33-20-22-8-6-11-24(16-22)25-12-7-13-28(17-25)32-21-27(31)19-30-15-14-23-9-4-5-10-26(23)18-30/h4-13,16-17,27,31H,14-15,18-21H2,1-3H3
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343857
PNG
(US9777008, Compound 151)
Show SMILES CN(C)c1ccc(cc1)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C26H30N2O2/c1-27(2)24-12-10-21(11-13-24)22-8-5-9-26(16-22)30-19-25(29)18-28-15-14-20-6-3-4-7-23(20)17-28/h3-13,16,25,29H,14-15,17-19H2,1-2H3
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343867
PNG
(US9777008, Compound 161)
Show SMILES OC(COc1cccc(NC(=O)c2cncnc2)c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C23H24N4O3/c28-21(14-27-9-8-17-4-1-2-5-18(17)13-27)15-30-22-7-3-6-20(10-22)26-23(29)19-11-24-16-25-12-19/h1-7,10-12,16,21,28H,8-9,13-15H2,(H,26,29)
PDB

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n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343878
PNG
(US9777008, Compound 172)
Show SMILES OC(COc1cccc(c1)-c1cccc(c1)C#N)CN1CCc2ccccc2C1
Show InChI InChI=1S/C25H24N2O2/c26-15-19-5-3-8-21(13-19)22-9-4-10-25(14-22)29-18-24(28)17-27-12-11-20-6-1-2-7-23(20)16-27/h1-10,13-14,24,28H,11-12,16-18H2
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343884
PNG
(US9777008, Compound 178)
Show SMILES Cn1cnc2ccc(cc12)-c1cccc(OCC(O)CN2CCc3ccccc3C2COc2ccccc2)c1
Show InChI InChI=1S/C33H33N3O3/c1-35-23-34-31-15-14-26(19-32(31)35)25-9-7-12-29(18-25)38-21-27(37)20-36-17-16-24-8-5-6-13-30(24)33(36)22-39-28-10-3-2-4-11-28/h2-15,18-19,23,27,33,37H,16-17,20-22H2,1H3
PDB

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n/an/a>4.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343903
PNG
(US9777008, Compound 197)
Show SMILES CN(C(=O)c1cn(C)cn1)c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C24H28N4O3/c1-26-15-23(25-17-26)24(30)27(2)20-8-5-9-22(12-20)31-16-21(29)14-28-11-10-18-6-3-4-7-19(18)13-28/h3-9,12,15,17,21,29H,10-11,13-14,16H2,1-2H3
PDB

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n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343904
PNG
(US9777008, Compound 198)
Show SMILES CN(C(=O)c1cocn1)c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C23H25N3O4/c1-25(23(28)22-15-29-16-24-22)19-7-4-8-21(11-19)30-14-20(27)13-26-10-9-17-5-2-3-6-18(17)12-26/h2-8,11,15-16,20,27H,9-10,12-14H2,1H3
PDB

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n/an/a 2.50E+4n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343912
PNG
(US9777008, Compound 206)
Show SMILES CNC(=O)Cn1ccc2cnc(nc12)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C27H29N5O3/c1-28-25(34)17-32-12-10-21-14-29-26(30-27(21)32)20-7-4-8-24(13-20)35-18-23(33)16-31-11-9-19-5-2-3-6-22(19)15-31/h2-8,10,12-14,23,33H,9,11,15-18H2,1H3,(H,28,34)
PDB

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n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343913
PNG
(US9777008, Compound 207)
Show SMILES Cn1cnc2ccc(cc12)-c1cc(NCC(O)CN2CCc3ccccc3C2)ncn1
Show InChI InChI=1S/C24H26N6O/c1-29-16-28-21-7-6-18(10-23(21)29)22-11-24(27-15-26-22)25-12-20(31)14-30-9-8-17-4-2-3-5-19(17)13-30/h2-7,10-11,15-16,20,31H,8-9,12-14H2,1H3,(H,25,26,27)
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343915
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(pyrro...)
Show SMILES OC(COc1cccc(c1)-c1ccc2ncn(C3CCNC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C29H32N4O2/c34-26(18-32-13-11-21-4-1-2-5-24(21)17-32)19-35-27-7-3-6-22(14-27)23-8-9-28-29(15-23)33(20-31-28)25-10-12-30-16-25/h1-9,14-15,20,25-26,30,34H,10-13,16-19H2
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343923
PNG
(US9777008, Compound 217)
Show SMILES Cn1cnc2ccc(cc12)-c1cc(NCC(O)CN2CCc3ccccc3C2)ccn1
Show InChI InChI=1S/C25H27N5O/c1-29-17-28-23-7-6-19(12-25(23)29)24-13-21(8-10-26-24)27-14-22(31)16-30-11-9-18-4-2-3-5-20(18)15-30/h2-8,10,12-13,17,22,31H,9,11,14-16H2,1H3,(H,26,27)
PDB

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n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343926
PNG
(US9777008, Compound 220)
Show SMILES OC(COc1cccc(c1)-c1ccc2ncn(C3CCNCC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C30H34N4O2/c35-27(19-33-15-12-22-4-1-2-5-25(22)18-33)20-36-28-7-3-6-23(16-28)24-8-9-29-30(17-24)34(21-32-29)26-10-13-31-14-11-26/h1-9,16-17,21,26-27,31,35H,10-15,18-20H2
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343927
PNG
(US9777008, Compound 221)
Show SMILES CN1CCC(CC1)n1cnc2ccc(cc12)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C31H36N4O2/c1-33-14-12-27(13-15-33)35-22-32-30-10-9-25(18-31(30)35)24-7-4-8-29(17-24)37-21-28(36)20-34-16-11-23-5-2-3-6-26(23)19-34/h2-10,17-18,22,27-28,36H,11-16,19-21H2,1H3
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343940
PNG
(2-(2-(2-((3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hy...)
Show SMILES OC(CNc1cc(ccn1)-c1ncc2ccn(CC(=O)N3CCOCC3)c2n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C29H33N7O3/c37-25(19-34-9-6-21-3-1-2-4-24(21)18-34)17-31-26-15-22(5-8-30-26)28-32-16-23-7-10-36(29(23)33-28)20-27(38)35-11-13-39-14-12-35/h1-5,7-8,10,15-16,25,37H,6,9,11-14,17-20H2,(H,30,31)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343945
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4-(7-methy...)
Show SMILES Cn1ccc2cnc(nc12)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C24H26N6O/c1-29-10-7-19-13-27-23(28-24(19)29)18-6-9-25-22(12-18)26-14-21(31)16-30-11-8-17-4-2-3-5-20(17)15-30/h2-7,9-10,12-13,21,31H,8,11,14-16H2,1H3,(H,25,26)
PDB

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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343946
PNG
(US9777008, Compound 240)
Show SMILES OC(CNc1cc(ccn1)-c1ccc2ncn(C3CCNC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C28H32N6O/c35-25(18-33-12-9-20-3-1-2-4-23(20)17-33)16-31-28-14-22(7-11-30-28)21-5-6-26-27(13-21)34(19-32-26)24-8-10-29-15-24/h1-7,11,13-14,19,24-25,29,35H,8-10,12,15-18H2,(H,30,31)
PDB

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PC cid
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%