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Patent code US9783488

Compile Data Set for Download or QSAR
Found 107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344295
PNG
((1R*,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- ...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@@H](C1)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C19H20FNO2/c1-13-16(8-5-9-17(13)20)19(18(22)21-23)11-10-15(12-19)14-6-3-2-4-7-14/h2-9,15,23H,10-12H2,1H3,(H,21,22)/t15-,19+/m0/s1
PDB
MMDB

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US Patent
n/an/a 40n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344365
PNG
((1S,3S*)-3-(1- (Difluoromethyl)-1H- indazol-6-yl)-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2cnn(C(F)F)c2c1)C(=O)NO
Show InChI InChI=1S/C21H20F3N3O2/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)8-7-14(10-21)13-5-6-15-11-25-27(20(23)24)18(15)9-13/h2-6,9,11,14,20,29H,7-8,10H2,1H3,(H,26,28)/t14-,21-/m0/s1
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n/an/a 46n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345231
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2ncccc2c1)C(=O)NO
Show InChI InChI=1S/C22H21FN2O2/c1-14-18(5-2-6-19(14)23)22(21(26)25-27)10-9-17(13-22)15-7-8-20-16(12-15)4-3-11-24-20/h2-8,11-12,17,27H,9-10,13H2,1H3,(H,25,26)/t17-,22-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344298
PNG
((1R*,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- ...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@H](C1)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C19H20FNO2/c1-13-16(8-5-9-17(13)20)19(18(22)21-23)11-10-15(12-19)14-6-3-2-4-7-14/h2-9,15,23H,10-12H2,1H3,(H,21,22)/t15-,19-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345230
PNG
((1S,3R*)-3-(7-Fluoro-1- methyl-1H-indazol-6-yl)-1-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2cnn(C)c2c1F)C(=O)NO
Show InChI InChI=1S/C21H21F2N3O2/c1-12-16(4-3-5-17(12)22)21(20(27)25-28)9-8-13(10-21)15-7-6-14-11-24-26(2)19(14)18(15)23/h3-7,11,13,28H,8-10H2,1-2H3,(H,25,27)/t13-,21+/m1/s1
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n/an/a 55n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345218
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2ncn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-16(4-3-5-17(13)22)21(20(26)24-27)9-8-15(11-21)14-6-7-18-19(10-14)25(2)12-23-18/h3-7,10,12,15,27H,8-9,11H2,1-2H3,(H,24,26)/t15-,21-/m0/s1
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n/an/a 59n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345232
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2ncccc2c1)C(=O)NO
Show InChI InChI=1S/C22H21FN2O2/c1-14-18(5-2-6-19(14)23)22(21(26)25-27)10-9-17(13-22)15-7-8-20-16(12-15)4-3-11-24-20/h2-8,11-12,17,27H,9-10,13H2,1H3,(H,25,26)/t17-,22+/m1/s1
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n/an/a 62n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344364
PNG
((1S,3R*)-3-(1- (Difluoromethyl)-1H- indazol-6-yl)-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2cnn(C(F)F)c2c1)C(=O)NO
Show InChI InChI=1S/C21H20F3N3O2/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)8-7-14(10-21)13-5-6-15-11-25-27(20(23)24)18(15)9-13/h2-6,9,11,14,20,29H,7-8,10H2,1H3,(H,26,28)/t14-,21+/m1/s1
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n/an/a 72n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344377
PNG
((1S,3R*)-3-(7-fluoro-1H-indazol-6-yl)-1-(3-fluoro-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2cn[nH]c2c1F)C(=O)NO
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n/an/a 73n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345221
PNG
((1S,3R*)-1-(3-Fluoro-2-methylphenyl)-N-hydroxy-3-(...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2nc([nH]c2c1)C(F)(F)F)C(=O)NO
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n/an/a 74n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345222
PNG
((1S,3S*)-3- (Benzo[d]thiazol-2-yl)-1- (3-fluoro-2-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1nc2ccccc2s1)C(=O)NO
Show InChI InChI=1S/C20H19FN2O2S/c1-12-14(5-4-6-15(12)21)20(19(24)23-25)10-9-13(11-20)18-22-16-7-2-3-8-17(16)26-18/h2-8,13,25H,9-11H2,1H3,(H,23,24)/t13-,20-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344359
PNG
((1S,3R*)-3-(1-(2-(diethylamino)ethyl)-1H-pyrazol-4...)
Show SMILES CCN(CC)CCn1cc(cn1)[C@@H]1CC[C@@](C1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C22H31FN4O2/c1-4-26(5-2)11-12-27-15-18(14-24-27)17-9-10-22(13-17,21(28)25-29)19-7-6-8-20(23)16(19)3/h6-8,14-15,17,29H,4-5,9-13H2,1-3H3,(H,25,28)/t17-,22+/m1/s1
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n/an/a 82n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344368
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccn2ccnc2c1)C(=O)NO
Show InChI InChI=1S/C20H20FN3O2/c1-13-16(3-2-4-17(13)21)20(19(25)23-26)7-5-15(12-20)14-6-9-24-10-8-22-18(24)11-14/h2-4,6,8-11,15,26H,5,7,12H2,1H3,(H,23,25)/t15-,20-/m0/s1
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n/an/a 82n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345233
PNG
((1S,3R*)-1-(3,4-difluoro-2-methylphenyl)-N-hydroxy...)
Show SMILES Cc1c(F)c(F)ccc1[C@@]1(CC[C@H](C1)c1ccc2cnn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H21F2N3O2/c1-12-16(5-6-17(22)19(12)23)21(20(27)25-28)8-7-14(10-21)13-3-4-15-11-24-26(2)18(15)9-13/h3-6,9,11,14,28H,7-8,10H2,1-2H3,(H,25,27)/t14-,21+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345195
PNG
((1S,3R*)-1-(3-fluoro-2-methylphenyl)-N-hydroxy-3-(...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2n(C)cnc2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-16(4-3-5-17(13)22)21(20(26)24-27)9-8-15(11-21)14-6-7-19-18(10-14)23-12-25(19)2/h3-7,10,12,15,27H,8-9,11H2,1-2H3,(H,24,26)/t15-,21+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344354
PNG
((1S,3R*)-3-(1-(Difluoromethyl)-1H-pyrazol-4-yl)-1-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cnn(c1)C(F)F)C(=O)NO
Show InChI InChI=1S/C17H18F3N3O2/c1-10-13(3-2-4-14(10)18)17(15(24)22-25)6-5-11(7-17)12-8-21-23(9-12)16(19)20/h2-4,8-9,11,16,25H,5-7H2,1H3,(H,22,24)/t11-,17+/m1/s1
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n/an/a 95n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344367
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccn2ccnc2c1)C(=O)NO
Show InChI InChI=1S/C20H20FN3O2/c1-13-16(3-2-4-17(13)21)20(19(25)23-26)7-5-15(12-20)14-6-9-24-10-8-22-18(24)11-14/h2-4,6,8-11,15,26H,5,7,12H2,1H3,(H,23,25)/t15-,20+/m1/s1
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n/an/a 98n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344297
PNG
((1S*,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- ...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C19H20FNO2/c1-13-16(8-5-9-17(13)20)19(18(22)21-23)11-10-15(12-19)14-6-3-2-4-7-14/h2-9,15,23H,10-12H2,1H3,(H,21,22)/t15-,19-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345156
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2n(C)ncc2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-17(4-3-5-18(13)22)21(20(26)24-27)9-8-15(11-21)14-6-7-19-16(10-14)12-23-25(19)2/h3-7,10,12,15,27H,8-9,11H2,1-2H3,(H,24,26)/t15-,21-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345160
PNG
((1S,3R*)-3-(2- (Difluoromethyl)-2H- indazol-6-yl)-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2cn(nc2c1)C(F)F)C(=O)NO
Show InChI InChI=1S/C21H20F3N3O2/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)8-7-14(10-21)13-5-6-15-11-27(20(23)24)25-18(15)9-13/h2-6,9,11,14,20,29H,7-8,10H2,1H3,(H,26,28)/t14-,21+/m1/s1
PDB
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n/an/a 110n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345153
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2n(C)ncc2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-17(4-3-5-18(13)22)21(20(26)24-27)9-8-15(11-21)14-6-7-19-16(10-14)12-23-25(19)2/h3-7,10,12,15,27H,8-9,11H2,1-2H3,(H,24,26)/t15-,21+/m1/s1
PDB
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n/an/a 110n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345229
PNG
((1S,3S*)-3-(7-Fluoro-1- methyl-1H-indazol-6-yl)-1-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2cnn(C)c2c1F)C(=O)NO
Show InChI InChI=1S/C21H21F2N3O2/c1-12-16(4-3-5-17(12)22)21(20(27)25-28)9-8-13(10-21)15-7-6-14-11-24-26(2)19(14)18(15)23/h3-7,11,13,28H,8-10H2,1-2H3,(H,25,27)/t13-,21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345217
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2ncn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-16(4-3-5-17(13)22)21(20(26)24-27)9-8-15(11-21)14-6-7-18-19(10-14)25(2)12-23-18/h3-7,10,12,15,27H,8-9,11H2,1-2H3,(H,24,26)/t15-,21+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345243
PNG
((1S,3S)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)Oc1ccccc1)C(=O)NO
Show InChI InChI=1S/C19H20FNO3/c1-13-16(8-5-9-17(13)20)19(18(22)21-23)11-10-15(12-19)24-14-6-3-2-4-7-14/h2-9,15,23H,10-12H2,1H3,(H,21,22)/t15-,19-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344355
PNG
((1S,3R*)-1-(3-fluoro-2-methylphenyl)-N-hydroxy-3-(...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cnn(CCN2CCOCC2)c1)C(=O)NO
Show InChI InChI=1S/C22H29FN4O3/c1-16-19(3-2-4-20(16)23)22(21(28)25-29)6-5-17(13-22)18-14-24-27(15-18)8-7-26-9-11-30-12-10-26/h2-4,14-15,17,29H,5-13H2,1H3,(H,25,28)/t17-,22+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344301
PNG
((1S,3R*)-1-(3-Fluoro-2- methyl-phenyl)-3-(5- fluor...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O2/c1-11-15(3-2-4-16(11)20)18(17(23)22-24)6-5-12(8-18)13-7-14(19)10-21-9-13/h2-4,7,9-10,12,24H,5-6,8H2,1H3,(H,22,23)/t12-,18+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344369
PNG
((1S,3R*)-3-(2-cyclopropyl-1-oxoisoindolin-5-yl)-1-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2C(=O)N(Cc2c1)C1CC1)C(=O)NO
Show InChI InChI=1S/C24H25FN2O3/c1-14-20(3-2-4-21(14)25)24(23(29)26-30)10-9-16(12-24)15-5-8-19-17(11-15)13-27(22(19)28)18-6-7-18/h2-5,8,11,16,18,30H,6-7,9-10,12-13H2,1H3,(H,26,29)/t16-,24+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344366
PNG
((1S,3R*)-1-(3-fluoro-2-methylphenyl)-N-hydroxy-3-(...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2cnn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-17(4-3-5-18(13)22)21(20(26)24-27)9-8-15(11-21)14-6-7-16-12-23-25(2)19(16)10-14/h3-7,10,12,15,27H,8-9,11H2,1-2H3,(H,24,26)/t15-,21+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345239
PNG
((1S,3S)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)Oc1ccc2cnn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O3/c1-13-17(4-3-5-18(13)22)21(20(26)24-27)9-8-16(11-21)28-15-7-6-14-12-23-25(2)19(14)10-15/h3-7,10,12,16,27H,8-9,11H2,1-2H3,(H,24,26)/t16-,21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345228
PNG
((1S,3R)-3-(5-Fluoro-1-methyl-1H-indazol-6-yl)-1-(3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cc2n(C)ncc2cc1F)C(=O)NO
Show InChI InChI=1S/C21H21F2N3O2/c1-12-16(4-3-5-17(12)22)21(20(27)25-28)7-6-13(10-21)15-9-19-14(8-18(15)23)11-24-26(19)2/h3-5,8-9,11,13,28H,6-7,10H2,1-2H3,(H,25,27)/t13-,21+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344323
PNG
(1-(3,4-Difluoro-2-methylphenyl)-N- hydroxycyclopen...)
Show SMILES Cc1c(F)c(F)ccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H15F2NO2/c1-8-9(4-5-10(14)11(8)15)13(12(17)16-18)6-2-3-7-13/h4-5,18H,2-3,6-7H2,1H3,(H,16,17)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344300
PNG
((1S,3S*)-1-(3-Fluoro-2- methyl-phenyl)-3-(5- fluor...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O2/c1-11-15(3-2-4-16(11)20)18(17(23)22-24)6-5-12(8-18)13-7-14(19)10-21-9-13/h2-4,7,9-10,12,24H,5-6,8H2,1H3,(H,22,23)/t12-,18-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345241
PNG
((1S,3S)-1-(3-Fluoro-2- methylphenyl)-3-((5- fluoro...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)Oc1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O3/c1-11-15(3-2-4-16(11)20)18(17(23)22-24)6-5-13(8-18)25-14-7-12(19)9-21-10-14/h2-4,7,9-10,13,24H,5-6,8H2,1H3,(H,22,23)/t13-,18-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345242
PNG
((1S,3R)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)Oc1ccccc1)C(=O)NO
Show InChI InChI=1S/C19H20FNO3/c1-13-16(8-5-9-17(13)20)19(18(22)21-23)11-10-15(12-19)24-14-6-3-2-4-7-14/h2-9,15,23H,10-12H2,1H3,(H,21,22)/t15-,19+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345223
PNG
((1S,3R*)-3- (Benzo-[d]thiazol-2-yl)-1- (3-fluoro-2...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1nc2ccccc2s1)C(=O)NO
Show InChI InChI=1S/C20H19FN2O2S/c1-12-14(5-4-6-15(12)21)20(19(24)23-25)10-9-13(11-20)18-22-16-7-2-3-8-17(16)26-18/h2-8,13,25H,9-11H2,1H3,(H,23,24)/t13-,20+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344363
PNG
(N-((R)-1- (Dipropylamino)propan-2- yl)-4-((1S*,3S)...)
Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)[C@H]1CC[C@@](C1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C29H40FN3O3/c1-5-16-33(17-6-2)19-20(3)31-27(34)23-12-10-22(11-13-23)24-14-15-29(18-24,28(35)32-36)25-8-7-9-26(30)21(25)4/h7-13,20,24,36H,5-6,14-19H2,1-4H3,(H,31,34)(H,32,35)/t20-,24+,29+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344299
PNG
((+-)-(1S*,3S*)1-(3-fluoro-2-methylphenyl)-N-hydrox...)
Show SMILES Cc1ccccc1[C@H]1CC[C@@](C1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C20H22FNO2/c1-13-6-3-4-7-16(13)15-10-11-20(12-15,19(23)22-24)17-8-5-9-18(21)14(17)2/h3-9,15,24H,10-12H2,1-2H3,(H,22,23)/t15-,20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344357
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccnn1C)C(=O)NO
Show InChI InChI=1S/C17H20FN3O2/c1-11-13(4-3-5-14(11)18)17(16(22)20-23)8-6-12(10-17)15-7-9-19-21(15)2/h3-5,7,9,12,23H,6,8,10H2,1-2H3,(H,20,22)/t12-,17+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344292
PNG
(1-(3-fluoro-2-methylphenyl)-N-hydroxy-3-(pyridin-3...)
Show SMILES Cc1c(F)cccc1C1(CCC(C1)c1cccnc1)C(=O)NO
Show InChI InChI=1S/C18H19FN2O2/c1-12-15(5-2-6-16(12)19)18(17(22)21-23)8-7-13(10-18)14-4-3-9-20-11-14/h2-6,9,11,13,23H,7-8,10H2,1H3,(H,21,22)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344353
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-3-(5-fluoro-...)
Show SMILES COc1ncc(cc1F)[C@@H]1CC[C@@](C1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C19H20F2N2O3/c1-11-14(4-3-5-15(11)20)19(18(24)23-25)7-6-12(9-19)13-8-16(21)17(26-2)22-10-13/h3-5,8,10,12,25H,6-7,9H2,1-2H3,(H,23,24)/t12-,19+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344362
PNG
(N-((R)-1- (Dipropylamino)propan-2- yl)-4-((1R*,3S)...)
Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)[C@@H]1CC[C@@](C1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C29H40FN3O3/c1-5-16-33(17-6-2)19-20(3)31-27(34)23-12-10-22(11-13-23)24-14-15-29(18-24,28(35)32-36)25-8-7-9-26(30)21(25)4/h7-13,20,24,36H,5-6,14-19H2,1-4H3,(H,31,34)(H,32,35)/t20-,24-,29+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344304
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoro...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc(F)cn1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O2/c1-11-14(3-2-4-15(11)20)18(17(23)22-24)8-7-12(9-18)16-6-5-13(19)10-21-16/h2-6,10,12,24H,7-9H2,1H3,(H,22,23)/t12-,18-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345240
PNG
((1S,3R)-1-(3-Fluoro-2- methylphenyl)-3-((5- fluoro...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)Oc1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O3/c1-11-15(3-2-4-16(11)20)18(17(23)22-24)6-5-13(8-18)25-14-7-12(19)9-21-10-14/h2-4,7,9-10,13,24H,5-6,8H2,1H3,(H,22,23)/t13-,18+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345173
PNG
((1S,3S*)-3-(2- (Difluoromethyl)-2H- indazol-6-yl)-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2cn(nc2c1)C(F)F)C(=O)NO
Show InChI InChI=1S/C21H20F3N3O2/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)8-7-14(10-21)13-5-6-15-11-27(20(23)24)25-18(15)9-13/h2-6,9,11,14,20,29H,7-8,10H2,1H3,(H,26,28)/t14-,21-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344305
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoro...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc(F)cn1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O2/c1-11-14(3-2-4-15(11)20)18(17(23)22-24)8-7-12(9-18)16-6-5-13(19)10-21-16/h2-6,10,12,24H,7-9H2,1H3,(H,22,23)/t12-,18+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345244
PNG
((1S,3S)-1-(3-fluoro-2-methylphenyl)-3-((4-fluorobe...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)OCc1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C20H21F2NO3/c1-13-17(3-2-4-18(13)22)20(19(24)23-25)10-9-16(11-20)26-12-14-5-7-15(21)8-6-14/h2-8,16,25H,9-12H2,1H3,(H,23,24)/t16-,20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344351
PNG
((1S,3R)-3-(2-cyclopropyl-5-fluoropyridin-3-yl)-1-(...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cc(F)cnc1C1CC1)C(=O)NO
Show InChI InChI=1S/C21H22F2N2O2/c1-12-17(3-2-4-18(12)23)21(20(26)25-27)8-7-14(10-21)16-9-15(22)11-24-19(16)13-5-6-13/h2-4,9,11,13-14,27H,5-8,10H2,1H3,(H,25,26)/t14-,21+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344358
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccnn1C)C(=O)NO
Show InChI InChI=1S/C17H20FN3O2/c1-11-13(4-3-5-14(11)18)17(16(22)20-23)8-6-12(10-17)15-7-9-19-21(15)2/h3-5,7,9,12,23H,6,8,10H2,1-2H3,(H,20,22)/t12-,17-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345220
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2OC(C)(C)CNc2c1)C(=O)NO
Show InChI InChI=1S/C23H27FN2O3/c1-14-17(5-4-6-18(14)24)23(21(27)26-28)10-9-16(12-23)15-7-8-20-19(11-15)25-13-22(2,3)29-20/h4-8,11,16,25,28H,9-10,12-13H2,1-3H3,(H,26,27)/t16-,23-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344311
PNG
(1-(3-fluoro-2-methylphenyl)-N-hydroxycyclopentanec...)
Show SMILES Cc1c(F)cccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H16FNO2/c1-9-10(5-4-6-11(9)14)13(12(16)15-17)7-2-3-8-13/h4-6,17H,2-3,7-8H2,1H3,(H,15,16)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344378
PNG
((1S,3R*)-3-(2-cyclopropylbenzo[d]oxazol-5-yl)-1-(3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2oc(nc2c1)C1CC1)C(=O)NO
Show InChI InChI=1S/C23H23FN2O3/c1-13-17(3-2-4-18(13)24)23(22(27)26-28)10-9-16(12-23)15-7-8-20-19(11-15)25-21(29-20)14-5-6-14/h2-4,7-8,11,14,16,28H,5-6,9-10,12H2,1H3,(H,26,27)/t16-,23+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344310
PNG
(1-(3-chloro-2-methylphenyl)-N-hydroxycyclopentanec...)
Show SMILES Cc1c(Cl)cccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H16ClNO2/c1-9-10(5-4-6-11(9)14)13(12(16)15-17)7-2-3-8-13/h4-6,17H,2-3,7-8H2,1H3,(H,15,16)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344293
PNG
((+-)-(1S*,3R*)-1-(3-Fluoro- 2-methylphenyl)-N- hyd...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cncnc1)C(=O)NO
Show InChI InChI=1S/C17H18FN3O2/c1-11-14(3-2-4-15(11)18)17(16(22)21-23)6-5-12(7-17)13-8-19-10-20-9-13/h2-4,8-10,12,23H,5-7H2,1H3,(H,21,22)/t12-,17+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345238
PNG
((1S,3R)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)Oc1ccc2cnn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H22FN3O3/c1-13-17(4-3-5-18(13)22)21(20(26)24-27)9-8-16(11-21)28-15-7-6-14-12-23-25(2)19(14)10-15/h3-7,10,12,16,27H,8-9,11H2,1-2H3,(H,24,26)/t16-,21+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345226
PNG
((1S,3S*)-3-(2- Cyclopropylbenzo[d]thiazol- 5-yl)-1...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2sc(nc2c1)C1CC1)C(=O)NO
Show InChI InChI=1S/C23H23FN2O2S/c1-13-17(3-2-4-18(13)24)23(22(27)26-28)10-9-16(12-23)15-7-8-20-19(11-15)25-21(29-20)14-5-6-14/h2-4,7-8,11,14,16,28H,5-6,9-10,12H2,1H3,(H,26,27)/t16-,23-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345219
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2OC(C)(C)CNc2c1)C(=O)NO
Show InChI InChI=1S/C23H27FN2O3/c1-14-17(5-4-6-18(14)24)23(21(27)26-28)10-9-16(12-23)15-7-8-20-19(11-15)25-13-22(2,3)29-20/h4-8,11,16,25,28H,9-10,12-13H2,1-3H3,(H,26,27)/t16-,23+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345224
PNG
((1S,3S*)-3-(2- Cyclopropylbenzo[d]thiazol- 6-yl)-1...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2nc(sc2c1)C1CC1)C(=O)NO
Show InChI InChI=1S/C23H23FN2O2S/c1-13-17(3-2-4-18(13)24)23(22(27)26-28)10-9-16(12-23)15-7-8-19-20(11-15)29-21(25-19)14-5-6-14/h2-4,7-8,11,14,16,28H,5-6,9-10,12H2,1H3,(H,26,27)/t16-,23-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344356
PNG
((1 S,3R*)-1-(3-Fluoro-2-methylphenyl)-3-(5-fluoro-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cnc(OCCN2CCCC2)c(F)c1)C(=O)NO
Show InChI InChI=1S/C24H29F2N3O3/c1-16-19(5-4-6-20(16)25)24(23(30)28-31)8-7-17(14-24)18-13-21(26)22(27-15-18)32-12-11-29-9-2-3-10-29/h4-6,13,15,17,31H,2-3,7-12,14H2,1H3,(H,28,30)/t17-,24+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345194
PNG
((1S,3S*)-3-(3-Fluoro-1- methyl-1H-indazol-6-yl)-1-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2c(F)nn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H21F2N3O2/c1-12-16(4-3-5-17(12)22)21(20(27)25-28)9-8-14(11-21)13-6-7-15-18(10-13)26(2)24-19(15)23/h3-7,10,14,28H,8-9,11H2,1-2H3,(H,25,27)/t14-,21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344326
PNG
(1-(3,5-Difluoro-2-methylphenyl)-N- hydroxycyclopen...)
Show SMILES Cc1c(F)cc(F)cc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H15F2NO2/c1-8-10(6-9(14)7-11(8)15)13(12(17)16-18)4-2-3-5-13/h6-7,18H,2-5H2,1H3,(H,16,17)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345227
PNG
((1S,3R*)-3-(2- Cyclopropylbenzo[d]thiazol- 5-yl)-1...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2sc(nc2c1)C1CC1)C(=O)NO
Show InChI InChI=1S/C23H23FN2O2S/c1-13-17(3-2-4-18(13)24)23(22(27)26-28)10-9-16(12-23)15-7-8-20-19(11-15)25-21(29-20)14-5-6-14/h2-4,7-8,11,14,16,28H,5-6,9-10,12H2,1H3,(H,26,27)/t16-,23+/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344352
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-3-(5-fluoro-...)
Show SMILES COc1ncc(cc1F)[C@H]1CC[C@@](C1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C19H20F2N2O3/c1-11-14(4-3-5-15(11)20)19(18(24)23-25)7-6-12(9-19)13-8-16(21)17(26-2)22-10-13/h3-5,8,10,12,25H,6-7,9H2,1-2H3,(H,23,24)/t12-,19-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345225
PNG
((1S,3R*)-3-(2- Cyclopropylbenzo[d]thiazol- 6-yl)-1...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2nc(sc2c1)C1CC1)C(=O)NO
Show InChI InChI=1S/C23H23FN2O2S/c1-13-17(3-2-4-18(13)24)23(22(27)26-28)10-9-16(12-23)15-7-8-19-20(11-15)29-21(25-19)14-5-6-14/h2-4,7-8,11,14,16,28H,5-6,9-10,12H2,1H3,(H,26,27)/t16-,23+/m1/s1
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n/an/a 340n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344376
PNG
((1S,3R*)-1-(3-fluoro-2-methylphenyl)-N-hydroxy-3-(...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1cccc2cnn(C)c12)C(=O)NO
Show InChI InChI=1S/C21H22FN3O2/c1-13-17(7-4-8-18(13)22)21(20(26)24-27)10-9-14(11-21)16-6-3-5-15-12-23-25(2)19(15)16/h3-8,12,14,27H,9-11H2,1-2H3,(H,24,26)/t14-,21+/m1/s1
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n/an/a 360n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344294
PNG
((+-)-(1S*,3S*)-1-(3-Fluoro- 2-methylphenyl)-N- hyd...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1cncnc1)C(=O)NO
Show InChI InChI=1S/C17H18FN3O2/c1-11-14(3-2-4-15(11)18)17(16(22)21-23)6-5-12(7-17)13-8-19-10-20-9-13/h2-4,8-10,12,23H,5-7H2,1H3,(H,21,22)/t12-,17-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345188
PNG
((1S,3R*)-3-(3-Fluoro-1- methyl-1H-indazol-6-yl)-1-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccc2c(F)nn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C21H21F2N3O2/c1-12-16(4-3-5-17(12)22)21(20(27)25-28)9-8-14(11-21)13-6-7-15-18(10-13)26(2)24-19(15)23/h3-7,10,14,28H,8-9,11H2,1-2H3,(H,25,27)/t14-,21+/m1/s1
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n/an/a 400n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344333
PNG
(1-(4-Fluoro-2-methylphenyl)-N- hydroxycyclopentane...)
Show SMILES Cc1cc(F)ccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H16FNO2/c1-9-8-10(14)4-5-11(9)13(12(16)15-17)6-2-3-7-13/h4-5,8,17H,2-3,6-7H2,1H3,(H,15,16)
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n/an/a 570n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344342
PNG
(1-(Benzo[b]thiophen-7-yl)-N- hydroxycyclopentaneca...)
Show SMILES ONC(=O)C1(CCCC1)c1cccc2ccsc12
Show InChI InChI=1S/C14H15NO2S/c16-13(15-17)14(7-1-2-8-14)11-5-3-4-10-6-9-18-12(10)11/h3-6,9,17H,1-2,7-8H2,(H,15,16)
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n/an/a 610n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345247
PNG
((1s,4s)-1-(3-Fluoro-2- methylphenyl)-4-(5- fluorop...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@@H](CC1)c1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C19H20F2N2O2/c1-12-16(3-2-4-17(12)21)19(18(24)23-25)7-5-13(6-8-19)14-9-15(20)11-22-10-14/h2-4,9-11,13,25H,5-8H2,1H3,(H,23,24)/t13-,19+
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n/an/a 660n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345248
PNG
((1r,4r)-1-(3-fluoro-2-methylphenyl)-N-hydroxy-4-ph...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](CC1)Oc1ccccc1)C(=O)NO
Show InChI InChI=1S/C20H22FNO3/c1-14-17(8-5-9-18(14)21)20(19(23)22-24)12-10-16(11-13-20)25-15-6-3-2-4-7-15/h2-9,16,24H,10-13H2,1H3,(H,22,23)/t16-,20-
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n/an/a 680n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344343
PNG
((1R,3S*)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoro...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@@H](C1)c1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O2/c1-11-15(3-2-4-16(11)20)18(17(23)22-24)6-5-12(8-18)13-7-14(19)10-21-9-13/h2-4,7,9-10,12,24H,5-6,8H2,1H3,(H,22,23)/t12-,18+/m0/s1
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n/an/a 720n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344318
PNG
(N-Hydroxy-1-o- tolylcyclopentanecarboxamide | US97...)
Show SMILES Cc1ccccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H17NO2/c1-10-6-2-3-7-11(10)13(12(15)14-16)8-4-5-9-13/h2-3,6-7,16H,4-5,8-9H2,1H3,(H,14,15)
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n/an/a 730n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344334
PNG
(1-(5-Fluoro-2-methylphenyl)-N- hydroxycyclopentane...)
Show SMILES Cc1ccc(F)cc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H16FNO2/c1-9-4-5-10(14)8-11(9)13(12(16)15-17)6-2-3-7-13/h4-5,8,17H,2-3,6-7H2,1H3,(H,15,16)
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n/an/a 830n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344327
PNG
(1-(2-Chloro-6-methylphenyl)-N- hydroxycyclopentane...)
Show SMILES Cc1cccc(Cl)c1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H16ClNO2/c1-9-5-4-6-10(14)11(9)13(12(16)15-17)7-2-3-8-13/h4-6,17H,2-3,7-8H2,1H3,(H,15,16)
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n/an/a 910n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345251
PNG
((1r,4r)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 4-...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](CC1)c1ccc2cnn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C22H24FN3O2/c1-14-18(4-3-5-19(14)23)22(21(27)25-28)10-8-15(9-11-22)16-6-7-17-13-24-26(2)20(17)12-16/h3-7,12-13,15,28H,8-11H2,1-2H3,(H,25,27)/t15-,22-
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n/an/a 950n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344328
PNG
(1-(2-Ethylphenyl)-N- hydroxycyclopentanecarboxamid...)
Show SMILES CCc1ccccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C14H19NO2/c1-2-11-7-3-4-8-12(11)14(13(16)15-17)9-5-6-10-14/h3-4,7-8,17H,2,5-6,9-10H2,1H3,(H,15,16)
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n/an/a 1.10E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344296
PNG
((1S*,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- ...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C19H20FNO2/c1-13-16(8-5-9-17(13)20)19(18(22)21-23)11-10-15(12-19)14-6-3-2-4-7-14/h2-9,15,23H,10-12H2,1H3,(H,21,22)/t15-,19+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345236
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)N1CCOCC1)C(=O)NO
Show InChI InChI=1S/C17H23FN2O3/c1-12-14(3-2-4-15(12)18)17(16(21)19-22)6-5-13(11-17)20-7-9-23-10-8-20/h2-4,13,22H,5-11H2,1H3,(H,19,21)/t13-,17+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345252
PNG
((+-)-2-(3-fluoro-2-methylphenyl)-N-hydroxy-8-oxasp...)
Show SMILES Cc1c(F)cccc1C1(CCC2(C1)CCOCC2)C(=O)NO
Show InChI InChI=1S/C17H22FNO3/c1-12-13(3-2-4-14(12)18)17(15(20)19-21)6-5-16(11-17)7-9-22-10-8-16/h2-4,21H,5-11H2,1H3,(H,19,20)
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n/an/a 1.40E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344350
PNG
((1S,3S)-3-(5- Fluoropyridin-3-yl)-N- hydroxy-1- ph...)
Show SMILES ONC(=O)[C@]1(CC[C@@H](C1)c1cncc(F)c1)c1ccccc1
Show InChI InChI=1S/C17H17FN2O2/c18-15-8-13(10-19-11-15)12-6-7-17(9-12,16(21)20-22)14-4-2-1-3-5-14/h1-5,8,10-12,22H,6-7,9H2,(H,20,21)/t12-,17-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344341
PNG
(1-(2-Fluoro-6-methylphenyl)-N- hydroxycyclopentane...)
Show SMILES Cc1cccc(F)c1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H16FNO2/c1-9-5-4-6-10(14)11(9)13(12(16)15-17)7-2-3-8-13/h4-6,17H,2-3,7-8H2,1H3,(H,15,16)
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n/an/a 1.50E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344349
PNG
((1S,3R)-3-(5- Fluoropyridin-3-yl)-N- hydroxy-1- ph...)
Show SMILES ONC(=O)[C@]1(CC[C@H](C1)c1cncc(F)c1)c1ccccc1
Show InChI InChI=1S/C17H17FN2O2/c18-15-8-13(10-19-11-15)12-6-7-17(9-12,16(21)20-22)14-4-2-1-3-5-14/h1-5,8,10-12,22H,6-7,9H2,(H,20,21)/t12-,17+/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344320
PNG
(1-(2-Chlorophenyl)-N- hydroxycyclopentanecarboxami...)
Show SMILES ONC(=O)C1(CCCC1)c1ccccc1Cl
Show InChI InChI=1S/C12H14ClNO2/c13-10-6-2-1-5-9(10)12(11(15)14-16)7-3-4-8-12/h1-2,5-6,16H,3-4,7-8H2,(H,14,15)
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n/an/a 1.90E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344315
PNG
(1-(2-Chloro-6-fluorophenyl)-N- hydroxycyclopentane...)
Show SMILES ONC(=O)C1(CCCC1)c1c(F)cccc1Cl
Show InChI InChI=1S/C12H13ClFNO2/c13-8-4-3-5-9(14)10(8)12(11(16)15-17)6-1-2-7-12/h3-5,17H,1-2,6-7H2,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345237
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)N1CCOCC1)C(=O)NO
Show InChI InChI=1S/C17H23FN2O3/c1-12-14(3-2-4-15(12)18)17(16(21)19-22)6-5-13(11-17)20-7-9-23-10-8-20/h2-4,13,22H,5-11H2,1H3,(H,19,21)/t13-,17-/m0/s1
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UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344308
PNG
(1-(2,3-difluorophenyl)-N-hydroxycyclopentanecarbox...)
Show SMILES ONC(=O)C1(CCCC1)c1cccc(F)c1F
Show InChI InChI=1S/C12H13F2NO2/c13-9-5-3-4-8(10(9)14)12(11(16)15-17)6-1-2-7-12/h3-5,17H,1-2,6-7H2,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344344
PNG
((1R,3R*)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoro...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@H](C1)c1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C18H18F2N2O2/c1-11-15(3-2-4-16(11)20)18(17(23)22-24)6-5-12(8-18)13-7-14(19)10-21-9-13/h2-4,7,9-10,12,24H,5-6,8H2,1H3,(H,22,23)/t12-,18-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345246
PNG
((1r,4r)-1-(3-Fluoro-2- methylphenyl)-4-(5- fluorop...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](CC1)c1cncc(F)c1)C(=O)NO
Show InChI InChI=1S/C19H20F2N2O2/c1-12-16(3-2-4-17(12)21)19(18(24)23-25)7-5-13(6-8-19)14-9-15(20)11-22-10-14/h2-4,9-11,13,25H,5-8H2,1H3,(H,23,24)/t13-,19-
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n/an/a 4.10E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345250
PNG
((1s,4s)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 4-...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@@H](CC1)c1ccc2cnn(C)c2c1)C(=O)NO
Show InChI InChI=1S/C22H24FN3O2/c1-14-18(4-3-5-19(14)23)22(21(27)25-28)10-8-15(9-11-22)16-6-7-17-13-24-26(2)20(17)12-16/h3-7,12-13,15,28H,8-11H2,1-2H3,(H,25,27)/t15-,22+
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n/an/a 4.20E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344312
PNG
(1-(2-fluorophenyl)-N-hydroxycyclopentanecarboxamid...)
Show SMILES ONC(=O)C1(CCCC1)c1ccccc1F
Show InChI InChI=1S/C12H14FNO2/c13-10-6-2-1-5-9(10)12(11(15)14-16)7-3-4-8-12/h1-2,5-6,16H,3-4,7-8H2,(H,14,15)
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n/an/a 4.60E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344306
PNG
((1r,4r)-4-(5-Fluoropyridin- 3-yl)-N-hydroxy-1- phe...)
Show SMILES ONC(=O)[C@]1(CC[C@@H](CC1)c1cncc(F)c1)c1ccccc1
Show InChI InChI=1S/C18H19FN2O2/c19-16-10-14(11-20-12-16)13-6-8-18(9-7-13,17(22)21-23)15-4-2-1-3-5-15/h1-5,10-13,23H,6-9H2,(H,21,22)/t13-,18-
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n/an/a 6.40E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345253
PNG
(N-hydroxy-1-phenylcycloheptanecarboxamide | US9783...)
Show SMILES ONC(=O)C1(CCCCCC1)c1ccccc1
Show InChI InChI=1S/C14H19NO2/c16-13(15-17)14(10-6-1-2-7-11-14)12-8-4-3-5-9-12/h3-5,8-9,17H,1-2,6-7,10-11H2,(H,15,16)
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n/an/a 6.90E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344319
PNG
(N-Hydroxy-1-m- tolylcyclopentanecarboxamide | US97...)
Show SMILES Cc1cccc(c1)C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H17NO2/c1-10-5-4-6-11(9-10)13(12(15)14-16)7-2-3-8-13/h4-6,9,16H,2-3,7-8H2,1H3,(H,14,15)
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n/an/a 8.20E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344332
PNG
(N-Hydroxy-1-(2- (trifluoromethyl)phenyl) cyclopent...)
Show SMILES ONC(=O)C1(CCCC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C13H14F3NO2/c14-13(15,16)10-6-2-1-5-9(10)12(11(18)17-19)7-3-4-8-12/h1-2,5-6,19H,3-4,7-8H2,(H,17,18)
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n/an/a 1.10E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344314
PNG
(N-Hydroxy-1- phenylcyclopentanecarboxamide | US978...)
Show SMILES ONC(=O)C1(CCCC1)c1ccccc1
Show InChI InChI=1S/C12H15NO2/c14-11(13-15)12(8-4-5-9-12)10-6-2-1-3-7-10/h1-3,6-7,15H,4-5,8-9H2,(H,13,14)
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n/an/a 1.14E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345249
PNG
((1s,4s)-1-(3-fluoro-2-methylphenyl)-4-((4-fluorobe...)
Show SMILES Cc1c(F)cccc1[C@]1(CC[C@@H](CC1)OCc1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C21H23F2NO3/c1-14-18(3-2-4-19(14)23)21(20(25)24-26)11-9-17(10-12-21)27-13-15-5-7-16(22)8-6-15/h2-8,17,26H,9-13H2,1H3,(H,24,25)/t17-,21+
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n/an/a 1.40E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345234
PNG
((1S,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@H](C1)N1CCCC1)C(=O)NO
Show InChI InChI=1S/C17H23FN2O2/c1-12-14(5-4-6-15(12)18)17(16(21)19-22)8-7-13(11-17)20-9-2-3-10-20/h4-6,13,22H,2-3,7-11H2,1H3,(H,19,21)/t13-,17+/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344313
PNG
(1-(4-chlorophenyl)-N-hydroxycyclopentanecarboxamid...)
Show SMILES ONC(=O)C1(CCCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C12H14ClNO2/c13-10-5-3-9(4-6-10)12(11(15)14-16)7-1-2-8-12/h3-6,16H,1-2,7-8H2,(H,14,15)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345235
PNG
((1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3...)
Show SMILES Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)N1CCCC1)C(=O)NO
Show InChI InChI=1S/C17H23FN2O2/c1-12-14(5-4-6-15(12)18)17(16(21)19-22)8-7-13(11-17)20-9-2-3-10-20/h4-6,13,22H,2-3,7-11H2,1H3,(H,19,21)/t13-,17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344309
PNG
(1-(2,3-dihydrobenzofuran-7-yl)-N-hydroxycyclopenta...)
Show SMILES ONC(=O)C1(CCCC1)c1cccc2CCOc12
Show InChI InChI=1S/C14H17NO3/c16-13(15-17)14(7-1-2-8-14)11-5-3-4-10-6-9-18-12(10)11/h3-5,17H,1-2,6-9H2,(H,15,16)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344307
PNG
((1s,4s)-4-(5- Fluoropyridin-3-yl)-N- hydroxy-1- ph...)
Show SMILES ONC(=O)[C@@]1(CC[C@@H](CC1)c1cncc(F)c1)c1ccccc1
Show InChI InChI=1S/C18H19FN2O2/c19-16-10-14(11-20-12-16)13-6-8-18(9-7-13,17(22)21-23)15-4-2-1-3-5-15/h1-5,10-13,23H,6-9H2,(H,21,22)/t13-,18+
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345254
PNG
(1-(3-Fluoro-2-methylphenyl)-N-hydroxycycloheptanec...)
Show SMILES Cc1c(F)cccc1C1(CCCCCC1)C(=O)NO
Show InChI InChI=1S/C15H20FNO2/c1-11-12(7-6-8-13(11)16)15(14(18)17-19)9-4-2-3-5-10-15/h6-8,19H,2-5,9-10H2,1H3,(H,17,18)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344322
PNG
(1-(3-Cyanophenyl)-N- hydroxycyclopentanecarboxamid...)
Show SMILES ONC(=O)C1(CCCC1)c1cccc(c1)C#N
Show InChI InChI=1S/C13H14N2O2/c14-9-10-4-3-5-11(8-10)13(12(16)15-17)6-1-2-7-13/h3-5,8,17H,1-2,6-7H2,(H,15,16)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344331
PNG
(N-Hydroxy-1-(3-methoxy-2- (trifluoromethyl)phenyl)...)
Show SMILES COc1cccc(c1C(F)(F)F)C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C14H16F3NO3/c1-21-10-6-4-5-9(11(10)14(15,16)17)13(12(19)18-20)7-2-3-8-13/h4-6,20H,2-3,7-8H2,1H3,(H,18,19)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM345245
PNG
(1-phenyl-N-hydroxycyclohexylcarboxamide | US978348...)
Show SMILES ONC(=O)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C13H17NO2/c15-12(14-16)13(9-5-2-6-10-13)11-7-3-1-4-8-11/h1,3-4,7-8,16H,2,5-6,9-10H2,(H,14,15)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344317
PNG
(N-Hydroxy-1-(2- methoxyphenyl) cyclopentanecarboxa...)
Show SMILES COc1ccccc1C1(CCCC1)C(=O)NO
Show InChI InChI=1S/C13H17NO3/c1-17-11-7-3-2-6-10(11)13(12(15)14-16)8-4-5-9-13/h2-3,6-7,16H,4-5,8-9H2,1H3,(H,14,15)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM344321
PNG
(1-(2-Cyanophenyl)-N- hydroxycyclopentanecarboxamid...)
Show SMILES ONC(=O)C1(CCCC1)c1ccccc1C#N
Show InChI InChI=1S/C13H14N2O2/c14-9-10-5-1-2-6-11(10)13(12(16)15-17)7-3-4-8-13/h1-2,5-6,17H,3-4,7-8H2,(H,15,16)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...


US Patent US9783488 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%