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Patent code US9783499

Compile Data Set for Download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344393
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl...)
Show SMILES CC\C(=N/N(C(N)=O)c1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1)c1ccccc1
Show InChI InChI=1S/C34H38FN5O4/c1-3-28(24-11-6-4-7-12-24)38-40(34(36)41)25-13-14-31(27(35)21-25)44-30-15-16-37-29-23-33(32(42-2)22-26(29)30)43-20-10-19-39-17-8-5-9-18-39/h4,6-7,11-16,21-23H,3,5,8-10,17-20H2,1-2H3,(H2,36,41)/b38-28+
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US Patent
n/an/a 0.200n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344384
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperi...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3ccc(F)cc3)C(N)=O)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C33H35F2N5O4/c1-22-11-15-39(16-12-22)14-3-17-43-32-20-28-26(19-31(32)42-2)29(10-13-37-28)44-30-9-8-25(18-27(30)35)40(33(36)41)38-21-23-4-6-24(34)7-5-23/h4-10,13,18-22H,3,11-12,14-17H2,1-2H3,(H2,36,41)/b38-21+
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n/an/a 7n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344388
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperi...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3ccc(F)cc3F)C(N)=O)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C33H34F3N5O4/c1-21-9-13-40(14-10-21)12-3-15-44-32-19-28-25(18-31(32)43-2)29(8-11-38-28)45-30-7-6-24(17-27(30)36)41(33(37)42)39-20-22-4-5-23(34)16-26(22)35/h4-8,11,16-21H,3,9-10,12-15H2,1-2H3,(H2,37,42)/b39-20+
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n/an/a 7.10n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344396
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(morpholin-4-yl...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3cccc(CC=C)c3O)C(N)=S)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H36FN5O5S/c1-3-6-23-7-4-8-24(33(23)41)22-38-40(34(36)46)25-9-10-30(27(35)19-25)45-29-11-12-37-28-21-32(31(42-2)20-26(28)29)44-16-5-13-39-14-17-43-18-15-39/h3-4,7-12,19-22,41H,1,5-6,13-18H2,2H3,(H2,36,46)/b38-22+
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n/an/a 12n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344379
PNG
( (E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-...)
Show SMILES COc1cc2c(Oc3ccc(NNC(=O)\N=C\c4ccccc4)cc3F)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C31H32FN5O4/c1-39-29-19-24-26(20-30(29)40-17-7-16-37-14-5-6-15-37)33-13-12-27(24)41-28-11-10-23(18-25(28)32)35-36-31(38)34-21-22-8-3-2-4-9-22/h2-4,8-13,18-21,35H,5-7,14-17H2,1H3,(H,36,38)/b34-21+
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n/an/a 17n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344390
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-y...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3cccc(CC=C)c3O)C(N)=O)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C34H36FN5O5/c1-3-8-23-9-6-10-24(33(23)41)22-38-40(34(36)42)25-11-12-30(27(35)19-25)45-29-13-14-37-28-21-32(31(43-2)20-26(28)29)44-18-7-17-39-15-4-5-16-39/h3,6,9-14,19-22,41H,1,4-5,7-8,15-18H2,2H3,(H2,36,42)/b38-22+
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n/an/a 20n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344397
PNG
((E)-N1-(2-fluorophenyl)-N4-(3-fluoro-4-(6-methoxy-...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4ccccc4F)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H33F2N5O4/c1-41-30-19-23-26(20-31(30)42-17-7-16-38-14-5-2-6-15-38)36-13-12-28(23)43-29-11-10-22(18-25(29)34)21-37-39(32(35)40)27-9-4-3-8-24(27)33/h3-4,8-13,18-21H,2,5-7,14-17H2,1H3,(H2,35,40)/b37-21+
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n/an/a 21n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344381
PNG
( (E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-y...)
Show SMILES COc1cc2c(Oc3ccc(NNC(=O)\N=C\c4ccccc4)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H34FN5O4/c1-40-30-20-25-27(21-31(30)41-18-8-17-38-15-6-3-7-16-38)34-14-13-28(25)42-29-12-11-24(19-26(29)33)36-37-32(39)35-22-23-9-4-2-5-10-23/h2,4-5,9-14,19-22,36H,3,6-8,15-18H2,1H3,(H,37,39)/b35-22+
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n/an/a 30n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344398
PNG
((E)-N1-(3,5-dichlorophenyl)-N4-(3-fluoro-4-(6-meth...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4cc(Cl)cc(Cl)c4)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H32Cl2FN5O4/c1-42-30-18-25-27(19-31(30)43-13-5-12-39-10-3-2-4-11-39)37-9-8-28(25)44-29-7-6-21(14-26(29)35)20-38-40(32(36)41)24-16-22(33)15-23(34)17-24/h6-9,14-20H,2-5,10-13H2,1H3,(H2,36,41)/b38-20+
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n/an/a 110n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344383
PNG
( (E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-...)
Show SMILES COc1cccc(\C=N\N(C(N)=O)c2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)c1
Show InChI InChI=1S/C33H36FN5O5/c1-41-25-9-6-8-23(18-25)22-37-39(33(35)40)24-10-11-30(27(34)19-24)44-29-12-13-36-28-21-32(31(42-2)20-26(28)29)43-17-7-16-38-14-4-3-5-15-38/h6,8-13,18-22H,3-5,7,14-17H2,1-2H3,(H2,35,40)/b37-22+
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n/an/a 150n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344395
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(morpholin-4-yl...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3ccccc3[N+]([O-])=O)C(N)=S)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C31H31FN6O6S/c1-41-29-18-23-25(19-30(29)43-14-4-11-36-12-15-42-16-13-36)34-10-9-27(23)44-28-8-7-22(17-24(28)32)37(31(33)45)35-20-21-5-2-3-6-26(21)38(39)40/h2-3,5-10,17-20H,4,11-16H2,1H3,(H2,33,45)/b35-20+
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n/an/a 200n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344380
PNG
( (E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiper...)
Show SMILES COc1cc2c(Oc3ccc(NNC(=O)\N=C\c4ccccc4)cc3F)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C33H36FN5O4/c1-23-12-16-39(17-13-23)15-6-18-42-32-21-28-26(20-31(32)41-2)29(11-14-35-28)43-30-10-9-25(19-27(30)34)37-38-33(40)36-22-24-7-4-3-5-8-24/h3-5,7-11,14,19-23,37H,6,12-13,15-18H2,1-2H3,(H,38,40)/b36-22+
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n/an/a 200n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344385
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-y...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3ccc(F)cc3Cl)C(N)=O)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C31H30ClF2N5O4/c1-41-29-17-23-26(18-30(29)42-14-4-13-38-11-2-3-12-38)36-10-9-27(23)43-28-8-7-22(16-25(28)34)39(31(35)40)37-19-20-5-6-21(33)15-24(20)32/h5-10,15-19H,2-4,11-14H2,1H3,(H2,35,40)/b37-19+
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n/an/a 300n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344387
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-y...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3cccc(c3)C(F)(F)F)C(N)=O)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C32H31F4N5O4/c1-43-29-18-24-26(19-30(29)44-15-5-14-40-12-2-3-13-40)38-11-10-27(24)45-28-9-8-23(17-25(28)33)41(31(37)42)39-20-21-6-4-7-22(16-21)32(34,35)36/h4,6-11,16-20H,2-3,5,12-15H2,1H3,(H2,37,42)/b39-20+
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Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344394
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-y...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3ccccc3[N+]([O-])=O)C(N)=S)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C31H31FN6O5S/c1-41-29-18-23-25(19-30(29)42-16-6-15-36-13-4-5-14-36)34-12-11-27(23)43-28-10-9-22(17-24(28)32)37(31(33)44)35-20-21-7-2-3-8-26(21)38(39)40/h2-3,7-12,17-20H,4-6,13-16H2,1H3,(H2,33,44)/b35-20+
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n/an/a 390n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344403
PNG
((E)-N1-(3,5-difluorophenyl)-N4-(3-fluoro-4-(6-meth...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4cc(F)cc(F)c4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C31H30F3N5O5/c1-41-29-17-24-26(18-30(29)43-10-2-7-38-8-11-42-12-9-38)36-6-5-27(24)44-28-4-3-20(13-25(28)34)19-37-39(31(35)40)23-15-21(32)14-22(33)16-23/h3-6,13-19H,2,7-12H2,1H3,(H2,35,40)/b37-19+
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n/an/a 470n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344402
PNG
((E)-N1-phenyl-N4-(3-fluoro-4-(6-methoxy-7-(3-(morp...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4ccccc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C31H32FN5O5/c1-39-29-19-24-26(20-30(29)41-15-5-12-36-13-16-40-17-14-36)34-11-10-27(24)42-28-9-8-22(18-25(28)32)21-35-37(31(33)38)23-6-3-2-4-7-23/h2-4,6-11,18-21H,5,12-17H2,1H3,(H2,33,38)/b35-21+
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n/an/a 500n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344404
PNG
((E)-N1-(3,5-dimethoxyphenyl)-N4-(3-fluoro-4-(6-met...)
Show SMILES COc1cc(OC)cc(c1)N(\N=C\c1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1)C(N)=O
Show InChI InChI=1S/C35H40FN5O6/c1-23-9-13-40(14-10-23)12-5-15-46-34-21-30-28(20-33(34)45-4)31(8-11-38-30)47-32-7-6-24(16-29(32)36)22-39-41(35(37)42)25-17-26(43-2)19-27(18-25)44-3/h6-8,11,16-23H,5,9-10,12-15H2,1-4H3,(H2,37,42)/b39-22+
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n/an/a 510n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344382
PNG
( (E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-...)
Show SMILES COc1cccc(\C=N\N(C(N)=O)c2ccc(Oc3ccnc4cc(OCCCN5CCCC5)c(OC)cc34)c(F)c2)c1
Show InChI InChI=1S/C32H34FN5O5/c1-40-24-8-5-7-22(17-24)21-36-38(32(34)39)23-9-10-29(26(33)18-23)43-28-11-12-35-27-20-31(30(41-2)19-25(27)28)42-16-6-15-37-13-3-4-14-37/h5,7-12,17-21H,3-4,6,13-16H2,1-2H3,(H2,34,39)/b36-21+
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n/an/a 550n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344401
PNG
((E)-N1-(4-chlorophenyl)-N4-(3-fluoro-4-(6-methoxy-...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4ccc(Cl)cc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H34ClFN6O4/c1-38-13-15-39(16-14-38)12-3-17-43-31-20-27-25(19-30(31)42-2)28(10-11-36-27)44-29-9-4-22(18-26(29)34)21-37-40(32(35)41)24-7-5-23(33)6-8-24/h4-11,18-21H,3,12-17H2,1-2H3,(H2,35,41)/b37-21+
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n/an/a 580n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344400
PNG
((E)-N1-phenyl-N4-(3-fluoro-4-(6-methoxy-7-(3-(4-me...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4ccccc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H35FN6O4/c1-37-14-16-38(17-15-37)13-6-18-42-31-21-27-25(20-30(31)41-2)28(11-12-35-27)43-29-10-9-23(19-26(29)33)22-36-39(32(34)40)24-7-4-3-5-8-24/h3-5,7-12,19-22H,6,13-18H2,1-2H3,(H2,34,40)/b36-22+
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n/an/a 660n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344386
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-y...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3ccccc3[N+]([O-])=O)C(N)=O)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C31H31FN6O6/c1-42-29-18-23-25(19-30(29)43-16-6-15-36-13-4-5-14-36)34-12-11-27(23)44-28-10-9-22(17-24(28)32)37(31(33)39)35-20-21-7-2-3-8-26(21)38(40)41/h2-3,7-12,17-20H,4-6,13-16H2,1H3,(H2,33,39)/b35-20+
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n/an/a 670n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344399
PNG
((E)-N1-(4-chloro-3-(trifluoromethyl)phenyl)-N4-(3-...)
Show SMILES COc1cc2c(Oc3ccc(\C=N\N(C(N)=O)c4ccc(Cl)c(c4)C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C33H33ClF4N6O4/c1-42-11-13-43(14-12-42)10-3-15-47-31-19-27-23(18-30(31)46-2)28(8-9-40-27)48-29-7-4-21(16-26(29)35)20-41-44(32(39)45)22-5-6-25(34)24(17-22)33(36,37)38/h4-9,16-20H,3,10-15H2,1-2H3,(H2,39,45)/b41-20+
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n/an/a 690n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344389
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(morpholin-4-yl...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N(\N=C\c3c(O)ccc4ccccc34)C(N)=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C35H34FN5O6/c1-44-33-20-26-29(21-34(33)46-16-4-13-40-14-17-45-18-15-40)38-12-11-31(26)47-32-10-8-24(19-28(32)36)41(35(37)43)39-22-27-25-6-3-2-5-23(25)7-9-30(27)42/h2-3,5-12,19-22,42H,4,13-18H2,1H3,(H2,37,43)/b39-22+
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n/an/a 710n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%