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Patent code US9783524

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 0.458n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a<0.508n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50391089
PNG
(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Show SMILES C#Cc1cccc(Nc2ncnc3cc4OCCOCCOCCOc4cc23)c1
Show InChI InChI=1S/C22H21N3O4/c1-2-16-4-3-5-17(12-16)25-22-18-13-20-21(14-19(18)23-15-24-22)29-11-9-27-7-6-26-8-10-28-20/h1,3-5,12-15H,6-11H2,(H,23,24,25)
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n/an/a 1.23n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM50391089
PNG
(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Show SMILES C#Cc1cccc(Nc2ncnc3cc4OCCOCCOCCOc4cc23)c1
Show InChI InChI=1S/C22H21N3O4/c1-2-16-4-3-5-17(12-16)25-22-18-13-20-21(14-19(18)23-15-24-22)29-11-9-27-7-6-26-8-10-28-20/h1,3-5,12-15H,6-11H2,(H,23,24,25)
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n/an/a 2.02n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM270538
PNG
(US10059688, Example 4 | US9783524, Example 4)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(N)=O)n1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H30ClN7O3/c1-33(2)16-10-12-34(13-11-16)17-8-9-21(22(14-17)37-3)31-26-29-15-19(27)25(32-26)30-20-7-5-4-6-18(20)23(35)24(28)36/h4-9,14-16H,10-13H2,1-3H3,(H2,28,36)(H2,29,30,31,32)
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n/an/a 4.08n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270544
PNG
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C28H34ClN7O3/c1-34(2)19-12-14-36(15-13-19)23-11-10-18(16-24(23)39-5)31-28-30-17-21(29)26(33-28)32-22-9-7-6-8-20(22)25(37)27(38)35(3)4/h6-11,16-17,19H,12-15H2,1-5H3,(H2,30,31,32,33)
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n/an/a 4.92n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM270544
PNG
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C28H34ClN7O3/c1-34(2)19-12-14-36(15-13-19)23-11-10-18(16-24(23)39-5)31-28-30-17-21(29)26(33-28)32-22-9-7-6-8-20(22)25(37)27(38)35(3)4/h6-11,16-17,19H,12-15H2,1-5H3,(H2,30,31,32,33)
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n/an/a 5.13n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270538
PNG
(US10059688, Example 4 | US9783524, Example 4)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(N)=O)n1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H30ClN7O3/c1-33(2)16-10-12-34(13-11-16)17-8-9-21(22(14-17)37-3)31-26-29-15-19(27)25(32-26)30-20-7-5-4-6-18(20)23(35)24(28)36/h4-9,14-16H,10-13H2,1-3H3,(H2,28,36)(H2,29,30,31,32)
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n/an/a 7.52n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM270543
PNG
(US10059688, Example 115 | US9783524, Example 115)
Show SMILES CN(C)CCOc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)cc1NC(=O)C=C
Show InChI InChI=1S/C27H30ClN7O4/c1-6-23(36)31-21-15-17(11-12-22(21)39-14-13-34(2)3)30-27-29-16-19(28)25(33-27)32-20-10-8-7-9-18(20)24(37)26(38)35(4)5/h6-12,15-16H,1,13-14H2,2-5H3,(H,31,36)(H2,29,30,32,33)
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n/an/a 8.62n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM344704
PNG
(Synthesis of Compound 74 | US9783524, Example 74)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C29H33ClN8O4/c1-6-25(39)32-21-15-22(24(42-5)16-23(21)38-13-11-37(4)12-14-38)34-29-31-17-19(30)27(35-29)33-20-10-8-7-9-18(20)26(40)28(41)36(2)3/h6-10,15-17H,1,11-14H2,2-5H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 9.33n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM270544
PNG
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C28H34ClN7O3/c1-34(2)19-12-14-36(15-13-19)23-11-10-18(16-24(23)39-5)31-28-30-17-21(29)26(33-28)32-22-9-7-6-8-20(22)25(37)27(38)35(3)4/h6-11,16-17,19H,12-15H2,1-5H3,(H2,30,31,32,33)
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n/an/a 10.8n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM270543
PNG
(US10059688, Example 115 | US9783524, Example 115)
Show SMILES CN(C)CCOc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)cc1NC(=O)C=C
Show InChI InChI=1S/C27H30ClN7O4/c1-6-23(36)31-21-15-17(11-12-22(21)39-14-13-34(2)3)30-27-29-16-19(28)25(33-27)32-20-10-8-7-9-18(20)24(37)26(38)35(4)5/h6-12,15-16H,1,13-14H2,2-5H3,(H,31,36)(H2,29,30,32,33)
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n/an/a 11.7n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM270539
PNG
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C26H30ClN7O3/c1-32(2)25(36)23(35)18-7-5-6-8-20(18)30-24-19(27)16-28-26(31-24)29-17-9-10-21(22(15-17)37-4)34-13-11-33(3)12-14-34/h5-10,15-16H,11-14H2,1-4H3,(H2,28,29,30,31)
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n/an/a 12.2n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 13.7n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM270542
PNG
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Show SMILES CN(C)C(=O)C(=O)c1ccccc1Nc1nc(Nc2ccc3OCCN(C(=O)C=C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H23ClN6O4/c1-4-21(33)32-11-12-36-20-10-9-15(13-19(20)32)28-25-27-14-17(26)23(30-25)29-18-8-6-5-7-16(18)22(34)24(35)31(2)3/h4-10,13-14H,1,11-12H2,2-3H3,(H2,27,28,29,30)
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n/an/a 14.7n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM270542
PNG
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Show SMILES CN(C)C(=O)C(=O)c1ccccc1Nc1nc(Nc2ccc3OCCN(C(=O)C=C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H23ClN6O4/c1-4-21(33)32-11-12-36-20-10-9-15(13-19(20)32)28-25-27-14-17(26)23(30-25)29-18-8-6-5-7-16(18)22(34)24(35)31(2)3/h4-10,13-14H,1,11-12H2,2-3H3,(H2,27,28,29,30)
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n/an/a 15.1n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM270540
PNG
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-14-10-11-19(35-4)18(12-14)29-24-26-13-16(25)22(30-24)28-17-9-7-6-8-15(17)21(33)23(34)31(2)3/h5-13H,1H2,2-4H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 15.4n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM344704
PNG
(Synthesis of Compound 74 | US9783524, Example 74)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C29H33ClN8O4/c1-6-25(39)32-21-15-22(24(42-5)16-23(21)38-13-11-37(4)12-14-38)34-29-31-17-19(30)27(35-29)33-20-10-8-7-9-18(20)26(40)28(41)36(2)3/h6-10,15-17H,1,11-14H2,2-5H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 15.5n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM344704
PNG
(Synthesis of Compound 74 | US9783524, Example 74)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C29H33ClN8O4/c1-6-25(39)32-21-15-22(24(42-5)16-23(21)38-13-11-37(4)12-14-38)34-29-31-17-19(30)27(35-29)33-20-10-8-7-9-18(20)26(40)28(41)36(2)3/h6-10,15-17H,1,11-14H2,2-5H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 15.8n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 16.6n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM270540
PNG
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-14-10-11-19(35-4)18(12-14)29-24-26-13-16(25)22(30-24)28-17-9-7-6-8-15(17)21(33)23(34)31(2)3/h5-13H,1H2,2-4H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 17.3n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270543
PNG
(US10059688, Example 115 | US9783524, Example 115)
Show SMILES CN(C)CCOc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)cc1NC(=O)C=C
Show InChI InChI=1S/C27H30ClN7O4/c1-6-23(36)31-21-15-17(11-12-22(21)39-14-13-34(2)3)30-27-29-16-19(28)25(33-27)32-20-10-8-7-9-18(20)24(37)26(38)35(4)5/h6-12,15-16H,1,13-14H2,2-5H3,(H,31,36)(H2,29,30,32,33)
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n/an/a 18.7n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270540
PNG
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-14-10-11-19(35-4)18(12-14)29-24-26-13-16(25)22(30-24)28-17-9-7-6-8-15(17)21(33)23(34)31(2)3/h5-13H,1H2,2-4H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 18.9n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270542
PNG
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Show SMILES CN(C)C(=O)C(=O)c1ccccc1Nc1nc(Nc2ccc3OCCN(C(=O)C=C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H23ClN6O4/c1-4-21(33)32-11-12-36-20-10-9-15(13-19(20)32)28-25-27-14-17(26)23(30-25)29-18-8-6-5-7-16(18)22(34)24(35)31(2)3/h4-10,13-14H,1,11-12H2,2-3H3,(H2,27,28,29,30)
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n/an/a 21.3n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM270539
PNG
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C26H30ClN7O3/c1-32(2)25(36)23(35)18-7-5-6-8-20(18)30-24-19(27)16-28-26(31-24)29-17-9-10-21(22(15-17)37-4)34-13-11-33(3)12-14-34/h5-10,15-16H,11-14H2,1-4H3,(H2,28,29,30,31)
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n/an/a 22.8n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM270538
PNG
(US10059688, Example 4 | US9783524, Example 4)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(N)=O)n1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H30ClN7O3/c1-33(2)16-10-12-34(13-11-16)17-8-9-21(22(14-17)37-3)31-26-29-15-19(27)25(32-26)30-20-7-5-4-6-18(20)23(35)24(28)36/h4-9,14-16H,10-13H2,1-3H3,(H2,28,36)(H2,29,30,31,32)
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n/an/a 27.9n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270539
PNG
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C26H30ClN7O3/c1-32(2)25(36)23(35)18-7-5-6-8-20(18)30-24-19(27)16-28-26(31-24)29-17-9-10-21(22(15-17)37-4)34-13-11-33(3)12-14-34/h5-10,15-16H,11-14H2,1-4H3,(H2,28,29,30,31)
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n/an/a 38.2n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM270538
PNG
(US10059688, Example 4 | US9783524, Example 4)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(N)=O)n1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H30ClN7O3/c1-33(2)16-10-12-34(13-11-16)17-8-9-21(22(14-17)37-3)31-26-29-15-19(27)25(32-26)30-20-7-5-4-6-18(20)23(35)24(28)36/h4-9,14-16H,10-13H2,1-3H3,(H2,28,36)(H2,29,30,31,32)
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n/an/a 44.3n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270538
PNG
(US10059688, Example 4 | US9783524, Example 4)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(N)=O)n1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C26H30ClN7O3/c1-33(2)16-10-12-34(13-11-16)17-8-9-21(22(14-17)37-3)31-26-29-15-19(27)25(32-26)30-20-7-5-4-6-18(20)23(35)24(28)36/h4-9,14-16H,10-13H2,1-3H3,(H2,28,36)(H2,29,30,31,32)
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n/an/a 45.1n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270544
PNG
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C28H34ClN7O3/c1-34(2)19-12-14-36(15-13-19)23-11-10-18(16-24(23)39-5)31-28-30-17-21(29)26(33-28)32-22-9-7-6-8-20(22)25(37)27(38)35(3)4/h6-11,16-17,19H,12-15H2,1-5H3,(H2,30,31,32,33)
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n/an/a 77.6n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 101n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 108n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 145n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM270544
PNG
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C28H34ClN7O3/c1-34(2)19-12-14-36(15-13-19)23-11-10-18(16-24(23)39-5)31-28-30-17-21(29)26(33-28)32-22-9-7-6-8-20(22)25(37)27(38)35(3)4/h6-11,16-17,19H,12-15H2,1-5H3,(H2,30,31,32,33)
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n/an/a 158n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 179n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM270542
PNG
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Show SMILES CN(C)C(=O)C(=O)c1ccccc1Nc1nc(Nc2ccc3OCCN(C(=O)C=C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H23ClN6O4/c1-4-21(33)32-11-12-36-20-10-9-15(13-19(20)32)28-25-27-14-17(26)23(30-25)29-18-8-6-5-7-16(18)22(34)24(35)31(2)3/h4-10,13-14H,1,11-12H2,2-3H3,(H2,27,28,29,30)
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n/an/a 225n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270540
PNG
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-14-10-11-19(35-4)18(12-14)29-24-26-13-16(25)22(30-24)28-17-9-7-6-8-15(17)21(33)23(34)31(2)3/h5-13H,1H2,2-4H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 273n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270542
PNG
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Show SMILES CN(C)C(=O)C(=O)c1ccccc1Nc1nc(Nc2ccc3OCCN(C(=O)C=C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H23ClN6O4/c1-4-21(33)32-11-12-36-20-10-9-15(13-19(20)32)28-25-27-14-17(26)23(30-25)29-18-8-6-5-7-16(18)22(34)24(35)31(2)3/h4-10,13-14H,1,11-12H2,2-3H3,(H2,27,28,29,30)
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n/an/a 354n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270543
PNG
(US10059688, Example 115 | US9783524, Example 115)
Show SMILES CN(C)CCOc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)cc1NC(=O)C=C
Show InChI InChI=1S/C27H30ClN7O4/c1-6-23(36)31-21-15-17(11-12-22(21)39-14-13-34(2)3)30-27-29-16-19(28)25(33-27)32-20-10-8-7-9-18(20)24(37)26(38)35(4)5/h6-12,15-16H,1,13-14H2,2-5H3,(H,31,36)(H2,29,30,32,33)
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n/an/a 397n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 412n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM344704
PNG
(Synthesis of Compound 74 | US9783524, Example 74)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C29H33ClN8O4/c1-6-25(39)32-21-15-22(24(42-5)16-23(21)38-13-11-37(4)12-14-38)34-29-31-17-19(30)27(35-29)33-20-10-8-7-9-18(20)26(40)28(41)36(2)3/h6-10,15-17H,1,11-14H2,2-5H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 422n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM270540
PNG
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Show SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-14-10-11-19(35-4)18(12-14)29-24-26-13-16(25)22(30-24)28-17-9-7-6-8-15(17)21(33)23(34)31(2)3/h5-13H,1H2,2-4H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 500n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM344704
PNG
(Synthesis of Compound 74 | US9783524, Example 74)
Show SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1
Show InChI InChI=1S/C29H33ClN8O4/c1-6-25(39)32-21-15-22(24(42-5)16-23(21)38-13-11-37(4)12-14-38)34-29-31-17-19(30)27(35-29)33-20-10-8-7-9-18(20)26(40)28(41)36(2)3/h6-10,15-17H,1,11-14H2,2-5H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 513n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM270543
PNG
(US10059688, Example 115 | US9783524, Example 115)
Show SMILES CN(C)CCOc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)cc1NC(=O)C=C
Show InChI InChI=1S/C27H30ClN7O4/c1-6-23(36)31-21-15-17(11-12-22(21)39-14-13-34(2)3)30-27-29-16-19(28)25(33-27)32-20-10-8-7-9-18(20)24(37)26(38)35(4)5/h6-12,15-16H,1,13-14H2,2-5H3,(H,31,36)(H2,29,30,32,33)
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n/an/a 547n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM270539
PNG
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C26H30ClN7O3/c1-32(2)25(36)23(35)18-7-5-6-8-20(18)30-24-19(27)16-28-26(31-24)29-17-9-10-21(22(15-17)37-4)34-13-11-33(3)12-14-34/h5-10,15-16H,11-14H2,1-4H3,(H2,28,29,30,31)
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n/an/a 756n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50391089
PNG
(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Show SMILES C#Cc1cccc(Nc2ncnc3cc4OCCOCCOCCOc4cc23)c1
Show InChI InChI=1S/C22H21N3O4/c1-2-16-4-3-5-17(12-16)25-22-18-13-20-21(14-19(18)23-15-24-22)29-11-9-27-7-6-26-8-10-28-20/h1,3-5,12-15H,6-11H2,(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens (Human))
BDBM50391089
PNG
(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Show SMILES C#Cc1cccc(Nc2ncnc3cc4OCCOCCOCCOc4cc23)c1
Show InChI InChI=1S/C22H21N3O4/c1-2-16-4-3-5-17(12-16)25-22-18-13-20-21(14-19(18)23-15-24-22)29-11-9-27-7-6-26-8-10-28-20/h1,3-5,12-15H,6-11H2,(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM270539
PNG
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Show SMILES COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)C(=O)N(C)C)n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C26H30ClN7O3/c1-32(2)25(36)23(35)18-7-5-6-8-20(18)30-24-19(27)16-28-26(31-24)29-17-9-10-21(22(15-17)37-4)34-13-11-33(3)12-14-34/h5-10,15-16H,11-14H2,1-4H3,(H2,28,29,30,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BETTA PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4 Test Compound or 100 nL 100...


US Patent US9783524 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%