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Patent code US9783543

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345109
PNG
((trans-3-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyri...)
Show SMILES OC[C@H]1C[C@@H](C1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-11-12-7-14(8-12)21-18-5-6-19-20-10-15(23(19)22-18)17-9-13-3-1-2-4-16(13)25-17/h1-6,9-10,12,14,24H,7-8,11H2,(H,21,22)/t12-,14-
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345110
PNG
(3-(1-Benzofur-2-yl)-6-chloroimidazo[1,2-b]pyridazi...)
Show SMILES Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C14H8ClN3O/c15-13-5-6-14-16-8-10(18(14)17-13)12-7-9-3-1-2-4-11(9)19-12/h1-8H
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345111
PNG
((1S,2R)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@H]1CCC[C@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15+/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214649
PNG
(US9284319, R7 | US9730929, Example R7 | US9783543,...)
Show SMILES CN(C)CCNc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O/c1-22(2)10-9-19-17-7-8-18-20-12-14(23(18)21-17)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10H2,1-2H3,(H,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345109
PNG
((trans-3-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyri...)
Show SMILES OC[C@H]1C[C@@H](C1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-11-12-7-14(8-12)21-18-5-6-19-20-10-15(23(19)22-18)17-9-13-3-1-2-4-16(13)25-17/h1-6,9-10,12,14,24H,7-8,11H2,(H,21,22)/t12-,14-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345118
PNG
(US9783543, 10 | trans-4-{[3-(1-Benzofuran-2-yl)imi...)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-15-7-5-14(6-8-15)22-19-9-10-20-21-12-16(24(20)23-19)18-11-13-3-1-2-4-17(13)26-18/h1-4,9-12,14-15,25H,5-8H2,(H,22,23)/t14-,15-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214649
PNG
(US9284319, R7 | US9730929, Example R7 | US9783543,...)
Show SMILES CN(C)CCNc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O/c1-22(2)10-9-19-17-7-8-18-20-12-14(23(18)21-17)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10H2,1-2H3,(H,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345119
PNG
(US9783543, 11 | trans-3-{[3-(Furo[3,2-c]pyridin-2-...)
Show SMILES O[C@H]1C[C@@H](C1)Nc1ccc2ncc(-c3cc4cnccc4o3)n2n1
Show InChI InChI=1S/C17H15N5O2/c23-12-6-11(7-12)20-16-1-2-17-19-9-13(22(17)21-16)15-5-10-8-18-4-3-14(10)24-15/h1-5,8-9,11-12,23H,6-7H2,(H,20,21)/t11-,12-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345112
PNG
((1R,2R)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCC[C@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214648
PNG
(US9284319, R6 | US9730929, Example R6 | US9783543,...)
Show SMILES C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H17N5O/c1-2-7-18-15(5-1)13-19(27-18)17-14-24-21-9-8-20(25-26(17)21)23-12-10-16-6-3-4-11-22-16/h1-9,11,13-14H,10,12H2,(H,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345110
PNG
(3-(1-Benzofur-2-yl)-6-chloroimidazo[1,2-b]pyridazi...)
Show SMILES Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C14H8ClN3O/c15-13-5-6-14-16-8-10(18(14)17-13)12-7-9-3-1-2-4-11(9)19-12/h1-8H
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345114
PNG
((1S,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@H]1CCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214650
PNG
(US9284319, R8 | US9730929, Example R8 | US9783543,...)
Show SMILES C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Show InChI InChI=1S/C20H15N5O/c1-2-4-17-15(3-1)11-18(26-17)16-13-23-20-6-5-19(24-25(16)20)22-12-14-7-9-21-10-8-14/h1-11,13H,12H2,(H,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345115
PNG
((1R,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15+/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345111
PNG
((1S,2R)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@H]1CCC[C@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15+/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345118
PNG
(US9783543, 10 | trans-4-{[3-(1-Benzofuran-2-yl)imi...)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-15-7-5-14(6-8-15)22-19-9-10-20-21-12-16(24(20)23-19)18-11-13-3-1-2-4-17(13)26-18/h1-4,9-12,14-15,25H,5-8H2,(H,22,23)/t14-,15-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214650
PNG
(US9284319, R8 | US9730929, Example R8 | US9783543,...)
Show SMILES C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Show InChI InChI=1S/C20H15N5O/c1-2-4-17-15(3-1)11-18(26-17)16-13-23-20-6-5-19(24-25(16)20)22-12-14-7-9-21-10-8-14/h1-11,13H,12H2,(H,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345112
PNG
((1R,2R)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCC[C@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345113
PNG
((1R,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-16-7-3-2-6-14(16)22-19-9-10-20-21-12-15(24(20)23-19)18-11-13-5-1-4-8-17(13)26-18/h1,4-5,8-12,14,16,25H,2-3,6-7H2,(H,22,23)/t14-,16+/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345113
PNG
((1R,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-16-7-3-2-6-14(16)22-19-9-10-20-21-12-15(24(20)23-19)18-11-13-5-1-4-8-17(13)26-18/h1,4-5,8-12,14,16,25H,2-3,6-7H2,(H,22,23)/t14-,16+/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345119
PNG
(US9783543, 11 | trans-3-{[3-(Furo[3,2-c]pyridin-2-...)
Show SMILES O[C@H]1C[C@@H](C1)Nc1ccc2ncc(-c3cc4cnccc4o3)n2n1
Show InChI InChI=1S/C17H15N5O2/c23-12-6-11(7-12)20-16-1-2-17-19-9-13(22(17)21-16)15-5-10-8-18-4-3-14(10)24-15/h1-5,8-9,11-12,23H,6-7H2,(H,20,21)/t11-,12-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345114
PNG
((1S,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@H]1CCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214644
PNG
(US9284319, R2 | US9730929, Example R2 | US9783543,...)
Show SMILES N(c1ccccc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H13N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h1-12H,(H,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345115
PNG
((1R,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-15-6-3-5-13(15)21-18-8-9-19-20-11-14(23(19)22-18)17-10-12-4-1-2-7-16(12)25-17/h1-2,4,7-11,13,15,24H,3,5-6H2,(H,21,22)/t13-,15+/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345116
PNG
((1S,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@H]1CCCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-16-7-3-2-6-14(16)22-19-9-10-20-21-12-15(24(20)23-19)18-11-13-5-1-4-8-17(13)26-18/h1,4-5,8-12,14,16,25H,2-3,6-7H2,(H,22,23)/t14-,16-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214645
PNG
(US9284319, R2 | US9730929, Example R3 | US9783543,...)
Show SMILES C1CCC(CC1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H19N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h6-12,14H,1-5H2,(H,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345116
PNG
((1S,2S)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@H]1CCCC[C@@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-16-7-3-2-6-14(16)22-19-9-10-20-21-12-15(24(20)23-19)18-11-13-5-1-4-8-17(13)26-18/h1,4-5,8-12,14,16,25H,2-3,6-7H2,(H,22,23)/t14-,16-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214644
PNG
(US9284319, R2 | US9730929, Example R2 | US9783543,...)
Show SMILES N(c1ccccc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H13N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h1-12H,(H,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214643
PNG
(US9284319, R1 | US9730929, Example R1 | US9783543,...)
Show SMILES C(Nc1ccc2ncc(-c3ccncc3)n2n1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-4-14(5-3-1)12-20-17-6-7-18-21-13-16(23(18)22-17)15-8-10-19-11-9-15/h1-11,13H,12H2,(H,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214647
PNG
(US9284319, R5 | US9730929, Example R5 | US9783543,...)
Show SMILES C1CC(CCO1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H17N5O/c1-2-16-18-11-14(12-3-7-17-8-4-12)21(16)20-15(1)19-13-5-9-22-10-6-13/h1-4,7-8,11,13H,5-6,9-10H2,(H,19,20)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345117
PNG
((1R,2R)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCCC[C@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-16-7-3-2-6-14(16)22-19-9-10-20-21-12-15(24(20)23-19)18-11-13-5-1-4-8-17(13)26-18/h1,4-5,8-12,14,16,25H,2-3,6-7H2,(H,22,23)/t14-,16-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214645
PNG
(US9284319, R2 | US9730929, Example R3 | US9783543,...)
Show SMILES C1CCC(CC1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H19N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h6-12,14H,1-5H2,(H,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214646
PNG
(US9284319, R4 | US9730929, Example R4 | US9783543,...)
Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214648
PNG
(US9284319, R6 | US9730929, Example R6 | US9783543,...)
Show SMILES C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H17N5O/c1-2-7-18-15(5-1)13-19(27-18)17-14-24-21-9-8-20(25-26(17)21)23-12-10-16-6-3-4-11-22-16/h1-9,11,13-14H,10,12H2,(H,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345117
PNG
((1R,2R)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyr...)
Show SMILES O[C@@H]1CCCC[C@H]1Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-16-7-3-2-6-14(16)22-19-9-10-20-21-12-15(24(20)23-19)18-11-13-5-1-4-8-17(13)26-18/h1,4-5,8-12,14,16,25H,2-3,6-7H2,(H,22,23)/t14-,16-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214643
PNG
(US9284319, R1 | US9730929, Example R1 | US9783543,...)
Show SMILES C(Nc1ccc2ncc(-c3ccncc3)n2n1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-4-14(5-3-1)12-20-17-6-7-18-21-13-16(23(18)22-17)15-8-10-19-11-9-15/h1-11,13H,12H2,(H,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214647
PNG
(US9284319, R5 | US9730929, Example R5 | US9783543,...)
Show SMILES C1CC(CCO1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H17N5O/c1-2-16-18-11-14(12-3-7-17-8-4-12)21(16)20-15(1)19-13-5-9-22-10-6-13/h1-4,7-8,11,13H,5-6,9-10H2,(H,19,20)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM214646
PNG
(US9284319, R4 | US9730929, Example R4 | US9783543,...)
Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%