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Patent code US9790203

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347639
PNG
(4-(1-methyl-3-(4-((1-methyl-1H-imidazol-2-yl)ethyn...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1nccn1C)-c1ccncc1
Show InChI InChI=1S/C21H17N5/c1-25-14-13-23-20(25)8-5-16-3-6-18(7-4-16)21-19(15-26(2)24-21)17-9-11-22-12-10-17/h3-4,6-7,9-15H,1-2H3
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n/an/a<100n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347648
PNG
(2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1cnc2ccccc2n1)-c1ccncc1
Show InChI InChI=1S/C25H17N5/c1-30-17-22(19-12-14-26-15-13-19)25(29-30)20-9-6-18(7-10-20)8-11-21-16-27-23-4-2-3-5-24(23)28-21/h2-7,9-10,12-17H,1H3
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n/an/a<100n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347649
PNG
(2-methoxy-6-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3...)
Show SMILES COc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C23H18N4O/c1-27-16-21(18-12-14-24-15-13-18)23(26-27)19-9-6-17(7-10-19)8-11-20-4-3-5-22(25-20)28-2/h3-7,9-10,12-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347654
PNG
(2-methyl-6-[2-[4-[2-methyl-4-(4-pyridyl)pyrazol-3-...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1c(cnn1C)-c1ccncc1
Show InChI InChI=1S/C23H18N4/c1-17-4-3-5-21(26-17)11-8-18-6-9-20(10-7-18)23-22(16-25-27(23)2)19-12-14-24-15-13-19/h3-7,9-10,12-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347656
PNG
(4-[1-methyl-3-[4-[2-(6-methyl-2-pyridyl)ethynyl]ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccnnc1
Show InChI InChI=1S/C22H17N5/c1-16-4-3-5-20(25-16)11-8-17-6-9-18(10-7-17)22-21(15-27(2)26-22)19-12-13-23-24-14-19/h3-7,9-10,12-15H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347642
PNG
(2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)p...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1ccc2ccccc2n1)-c1ccncc1
Show InChI InChI=1S/C26H18N4/c1-30-18-24(20-14-16-27-17-15-20)26(29-30)22-9-6-19(7-10-22)8-12-23-13-11-21-4-2-3-5-25(21)28-23/h2-7,9-11,13-18H,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347643
PNG
(2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1ccc2ncccc2n1)-c1ccncc1
Show InChI InChI=1S/C25H17N5/c1-30-17-22(19-12-15-26-16-13-19)25(29-30)20-7-4-18(5-8-20)6-9-21-10-11-23-24(28-21)3-2-14-27-23/h2-5,7-8,10-17H,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347644
PNG
(2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1cn2ccccc2n1)-c1ccncc1
Show InChI InChI=1S/C24H17N5/c1-28-17-22(19-11-13-25-14-12-19)24(27-28)20-8-5-18(6-9-20)7-10-21-16-29-15-3-2-4-23(29)26-21/h2-6,8-9,11-17H,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347645
PNG
(6-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1ccc2cc[nH]c2n1)-c1ccncc1
Show InChI InChI=1S/C24H17N5/c1-29-16-22(18-10-13-25-14-11-18)23(28-29)19-5-2-17(3-6-19)4-8-21-9-7-20-12-15-26-24(20)27-21/h2-3,5-7,9-16H,1H3,(H,26,27)
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347637
PNG
(5-Fluoro-2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1ccc(F)cn1)-c1ccncc1
Show InChI InChI=1S/C22H15FN4/c1-27-15-21(17-10-12-24-13-11-17)22(26-27)18-5-2-16(3-6-18)4-8-20-9-7-19(23)14-25-20/h2-3,5-7,9-15H,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347646
PNG
(4-methyl-2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-...)
Show SMILES Cc1cc(nc2ccccc12)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C27H20N4/c1-19-17-23(29-26-6-4-3-5-24(19)26)12-9-20-7-10-22(11-8-20)27-25(18-31(2)30-27)21-13-15-28-16-14-21/h3-8,10-11,13-18H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347636
PNG
(5-methyl-2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...)
Show SMILES Cc1ccc(nc1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C23H18N4/c1-17-3-9-21(25-15-17)10-6-18-4-7-20(8-5-18)23-22(16-27(2)26-23)19-11-13-24-14-12-19/h3-5,7-9,11-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347638
PNG
(3-Methyl-2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...)
Show SMILES Cc1cccnc1C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C23H18N4/c1-17-4-3-13-25-22(17)10-7-18-5-8-20(9-6-18)23-21(16-27(2)26-23)19-11-14-24-15-12-19/h3-6,8-9,11-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347659
PNG
(2-[2-[2-methoxy-4-[1-methyl-4-(4-pyridyl)pyrazol-3...)
Show SMILES COc1cc(ccc1C#Cc1cccc(C)n1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C24H20N4O/c1-17-5-4-6-21(26-17)10-9-19-7-8-20(15-23(19)29-3)24-22(16-28(2)27-24)18-11-13-25-14-12-18/h4-8,11-16H,1-3H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347640
PNG
(4-Methyl-2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...)
Show SMILES Cc1ccnc(c1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C23H18N4/c1-17-9-14-25-21(15-17)8-5-18-3-6-20(7-4-18)23-22(16-27(2)26-23)19-10-12-24-13-11-19/h3-4,6-7,9-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347635
PNG
(2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)p...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1ccccn1)-c1ccncc1
Show InChI InChI=1S/C22H16N4/c1-26-16-21(18-11-14-23-15-12-18)22(25-26)19-8-5-17(6-9-19)7-10-20-4-2-3-13-24-20/h2-6,8-9,11-16H,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347641
PNG
(2-Methyl-6-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C23H18N4/c1-17-4-3-5-21(25-17)11-8-18-6-9-20(10-7-18)23-22(16-27(2)26-23)19-12-14-24-15-13-19/h3-7,9-10,12-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347650
PNG
(3-methoxy-2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3...)
Show SMILES COc1cccnc1C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C23H18N4O/c1-27-16-20(18-11-14-24-15-12-18)23(26-27)19-8-5-17(6-9-19)7-10-21-22(28-2)4-3-13-25-21/h3-6,8-9,11-16H,1-2H3
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n/an/a<100n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347647
PNG
(2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1nccs1)-c1ccncc1
Show InChI InChI=1S/C20H14N4S/c1-24-14-18(16-8-10-21-11-9-16)20(23-24)17-5-2-15(3-6-17)4-7-19-22-12-13-25-19/h2-3,5-6,8-14H,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347658
PNG
(2-[2-[4-[4-(4-methoxyphenyl)-1-methyl-pyrazol-3-yl...)
Show SMILES COc1ccc(cc1)-c1cn(C)nc1-c1ccc(cc1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C25H21N3O/c1-18-5-4-6-22(26-18)14-9-19-7-10-21(11-8-19)25-24(17-28(2)27-25)20-12-15-23(29-3)16-13-20/h4-8,10-13,15-17H,1-3H3
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n/an/a 150n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347653
PNG
(5-[1-methyl-3-[4-[2-(6-methyl-2-pyridyl)ethynyl]ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1cncnc1
Show InChI InChI=1S/C22H17N5/c1-16-4-3-5-20(25-16)11-8-17-6-9-18(10-7-17)22-21(14-27(2)26-22)19-12-23-15-24-13-19/h3-7,9-10,12-15H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347651
PNG
(3-[4-[2-(6-methyl-2-pyridyl)ethynyl]phenyl]-2-(4-p...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1c(nc2CCCn12)-c1ccncc1
Show InChI InChI=1S/C25H20N4/c1-18-4-2-5-22(27-18)12-9-19-7-10-21(11-8-19)25-24(20-13-15-26-16-14-20)28-23-6-3-17-29(23)25/h2,4-5,7-8,10-11,13-16H,3,6,17H2,1H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347655
PNG
(2-methyl-6-[2-[4-[1-methyl-4-(2-methylpyrazol-3-yl...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccnn1C
Show InChI InChI=1S/C22H19N5/c1-16-5-4-6-19(24-16)12-9-17-7-10-18(11-8-17)22-20(15-26(2)25-22)21-13-14-23-27(21)3/h4-8,10-11,13-15H,1-3H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347657
PNG
(2-methyl-6-[2-[4-[1-methyl-4-(3-pyridyl)pyrazol-3-...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1cccnc1
Show InChI InChI=1S/C23H18N4/c1-17-5-3-7-21(25-17)13-10-18-8-11-19(12-9-18)23-22(16-27(2)26-23)20-6-4-14-24-15-20/h3-9,11-12,14-16H,1-2H3
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ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM347652
PNG
(2-methyl-6-[2-[4-[1-methyl-4-(1H-pyrazol-4-yl)pyra...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1cn[nH]c1
Show InChI InChI=1S/C21H17N5/c1-15-4-3-5-19(24-15)11-8-16-6-9-17(10-7-16)21-20(14-26(2)25-21)18-12-22-23-13-18/h3-7,9-10,12-14H,1-2H3,(H,22,23)
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n/an/a 375n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...


US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%