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Patent code US9790212

Compile Data Set for Download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRC2 complex


(Homo sapiens (Human))
BDBM347682
PNG
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19?
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n/an/a<10n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347682
PNG
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19?
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n/an/a<10n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259359
PNG
(US9505745, 36 | US9790212, Example 36)
Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H35N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h7,12,14,18-19H,8-11,13H2,1-6H3,(H,26,29)(H,27,30)/b20-7+/t18-,19-
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n/an/a<10n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259371
PNG
(US9505745, 48 | US9790212, Example 48)
Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1
Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259355
PNG
(US9505745, 32 | US9790212, Example 32)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259356
PNG
(US9505745, 33 | US9790212, Example 33)
Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259341
PNG
(US9505745, 18 | US9790212, Example 18)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O3S/c1-7-28(18-10-8-17(9-11-18)27(4)5)24-16(3)20(14-32-24)22(29)25-13-19-21(31-6)12-15(2)26-23(19)30/h12,14,17-18H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t17-,18-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259367
PNG
(US9505745, 44 | US9505745, 45 | US9790212, Example...)
Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19-,20?
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259335
PNG
(US9505745, 12 | US9790212, Example 12)
Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259339
PNG
(US9505745, 16 | US9790212, Example 16)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C
Show InChI InChI=1S/C26H40N4O2S/c1-7-9-19-14-17(3)28-25(32)22(19)15-27-24(31)23-16-33-26(18(23)4)30(8-2)21-12-10-20(11-13-21)29(5)6/h14,16,20-21H,7-13,15H2,1-6H3,(H,27,31)(H,28,32)/t20-,21-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259342
PNG
(US9505745, 19 | US9790212, Example 19)
Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259341
PNG
(US9505745, 18 | US9790212, Example 18)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O3S/c1-7-28(18-10-8-17(9-11-18)27(4)5)24-16(3)20(14-32-24)22(29)25-13-19-21(31-6)12-15(2)26-23(19)30/h12,14,17-18H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t17-,18-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259369
PNG
(US9505745, 46 | US9505745, 47 | US9790212, Example...)
Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19+,20?
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347682
PNG
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19?
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259357
PNG
(US9505745, 34 | US9790212, Example 35)
Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C28H39N3O4S/c1-8-21(19-9-11-20(12-10-19)31-27(34)35-28(5,6)7)24-18(4)23(15-36-24)25(32)29-14-22-16(2)13-17(3)30-26(22)33/h8,13,15,19-20H,9-12,14H2,1-7H3,(H,29,32)(H,30,33)(H,31,34)/b21-8+/t19-,20-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259329
PNG
(US9505745, 6 | US9790212, Example 6)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259387
PNG
(US9505745, 64 | US9790212, Example 64)
Show SMILES CCN(C)[C@H]1CC[C@@H](CC1)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-7-28(6)19-9-11-20(12-10-19)29(8-2)25-18(5)22(15-32-25)23(30)26-14-21-16(3)13-17(4)27-24(21)31/h13,15,19-20H,7-12,14H2,1-6H3,(H,26,30)(H,27,31)/t19-,20-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259329
PNG
(US9505745, 6 | US9790212, Example 6)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259366
PNG
(US9505745, 43 | US9790212, Example 43)
Show SMILES CCC([C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H33N3O2S/c1-5-18(16-6-8-17(24)9-7-16)21-15(4)20(12-29-21)22(27)25-11-19-13(2)10-14(3)26-23(19)28/h10,12,16-18H,5-9,11,24H2,1-4H3,(H,25,27)(H,26,28)/t16-,17-,18?
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n/an/a 16n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259334
PNG
(US9505745, 11 | US9790212, Example 11)
Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32)
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n/an/a 16n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259327
PNG
(US9505745, 4 | US9790212, Example 4)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19-
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n/an/a 16n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259376
PNG
(US9505745, 53 | US9790212, Example 53)
Show SMILES CCN(C1CCOCC1)c1sc(Cl)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
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n/an/a 16n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259351
PNG
(US9505745, 28 | US9790212, Example 28)
Show SMILES CCC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)
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n/an/a 19n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259367
PNG
(US9505745, 44 | US9505745, 45 | US9790212, Example...)
Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19-,20?
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n/an/a 20n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259342
PNG
(US9505745, 19 | US9790212, Example 19)
Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259362
PNG
(US9505745, 39 | US9790212, Example 40)
Show SMILES CCC(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H39N3O4S/c1-8-20(19-9-11-30(12-10-19)26(33)34-27(5,6)7)23-18(4)22(15-35-23)24(31)28-14-21-16(2)13-17(3)29-25(21)32/h13,15,19-20H,8-12,14H2,1-7H3,(H,28,31)(H,29,32)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259373
PNG
(US9505745, 50 | US9790212, Example 50)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H35BrN4O2S/c1-7-29(18-10-8-17(9-11-18)28(5)6)24-16(4)20(21(25)32-24)23(31)26-13-19-14(2)12-15(3)27-22(19)30/h12,17-18H,7-11,13H2,1-6H3,(H,26,31)(H,27,30)/t17-,18-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259364
PNG
(US9505745, 41 | US9790212, Example 41)
Show SMILES CC[C@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t21-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259334
PNG
(US9505745, 11 | US9790212, Example 11)
Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259335
PNG
(US9505745, 12 | US9790212, Example 12)
Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347682
PNG
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Show SMILES CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19?
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259390
PNG
(US9505745, 67 | US9790212, Example 67)
Show SMILES CCN(C1CCNCC1F)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29FN4O2S/c1-5-26(18-6-7-23-10-17(18)22)21-14(4)16(11-29-21)19(27)24-9-15-12(2)8-13(3)25-20(15)28/h8,11,17-18,23H,5-7,9-10H2,1-4H3,(H,24,27)(H,25,28)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259327
PNG
(US9505745, 4 | US9790212, Example 4)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259374
PNG
(US9505745, 51 | US9790212, Example 51)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H35N5O2S/c1-7-30(19-10-8-18(9-11-19)29(5)6)25-17(4)22(21(13-26)33-25)24(32)27-14-20-15(2)12-16(3)28-23(20)31/h12,18-19H,7-11,14H2,1-6H3,(H,27,32)(H,28,31)/t18-,19-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259398
PNG
(US9505745, 75 | US9790212, Example 75)
Show SMILES CCN(C1CCOCC1)c1sc(-c2ccoc2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H31N3O4S/c1-5-28(19-7-10-31-11-8-19)25-17(4)21(22(33-25)18-6-9-32-14-18)24(30)26-13-20-15(2)12-16(3)27-23(20)29/h6,9,12,14,19H,5,7-8,10-11,13H2,1-4H3,(H,26,30)(H,27,29)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259339
PNG
(US9505745, 16 | US9790212, Example 16)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C
Show InChI InChI=1S/C26H40N4O2S/c1-7-9-19-14-17(3)28-25(32)22(19)15-27-24(31)23-16-33-26(18(23)4)30(8-2)21-12-10-20(11-13-21)29(5)6/h14,16,20-21H,7-13,15H2,1-6H3,(H,27,31)(H,28,32)/t20-,21-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259350
PNG
(US9505745, 27 | US9790212, Example 27)
Show SMILES CC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H34N4O2S/c1-14-11-15(2)25-23(29)19(14)12-24-22(28)20-13-30-21(16(20)3)17(4)27-9-7-18(8-10-27)26(5)6/h11,13,17-18H,7-10,12H2,1-6H3,(H,24,28)(H,25,29)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259377
PNG
(US9505745, 54 | US9790212, Example 54)
Show SMILES CCN(C1CCOCC1)c1sc(C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-15(4)19(16(5)29-22)21(27)23-12-18-13(2)11-14(3)24-20(18)26/h11,17H,6-10,12H2,1-5H3,(H,23,27)(H,24,26)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259328
PNG
(US9505745, 5 | US9790212, Example 5)
Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19+
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n/an/a 32n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259400
PNG
(US9505745, 77 | US9790212, Example 77)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(-c2ccoc2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C28H38N4O3S/c1-7-32(22-10-8-21(9-11-22)31(5)6)28-19(4)24(25(36-28)20-12-13-35-16-20)27(34)29-15-23-17(2)14-18(3)30-26(23)33/h12-14,16,21-22H,7-11,15H2,1-6H3,(H,29,34)(H,30,33)/t21-,22-
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n/an/a 32n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259399
PNG
(US9505745, 76 | US9790212, Example 76)
Show SMILES CCN(C1CCOCC1)c1sc(-c2ccco2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H31N3O4S/c1-5-28(18-8-11-31-12-9-18)25-17(4)21(22(33-25)20-7-6-10-32-20)24(30)26-14-19-15(2)13-16(3)27-23(19)29/h6-7,10,13,18H,5,8-9,11-12,14H2,1-4H3,(H,26,30)(H,27,29)
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n/an/a 32n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259328
PNG
(US9505745, 5 | US9790212, Example 5)
Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19+
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n/an/a 50n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259355
PNG
(US9505745, 32 | US9790212, Example 32)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20-
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n/an/a 50n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259362
PNG
(US9505745, 39 | US9790212, Example 40)
Show SMILES CCC(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H39N3O4S/c1-8-20(19-9-11-30(12-10-19)26(33)34-27(5,6)7)23-18(4)22(15-35-23)24(31)28-14-21-16(2)13-17(3)29-25(21)32/h13,15,19-20H,8-12,14H2,1-7H3,(H,28,31)(H,29,32)
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n/an/a 50n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259389
PNG
(US9505745, 66 | US9790212, Example 66)
Show SMILES CCN(C1CCN(CC1)C(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-8-10-27(11-9-19)15(2)3)24-18(6)21(14-31-24)22(29)25-13-20-16(4)12-17(5)26-23(20)30/h12,14-15,19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)
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n/an/a 63n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259351
PNG
(US9505745, 28 | US9790212, Example 28)
Show SMILES CCC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)
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n/an/a 63n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259325
PNG
(US9505745, 2 | US9790212, Example 2)
Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25)
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n/an/a 63n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259350
PNG
(US9505745, 27 | US9790212, Example 27)
Show SMILES CC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H34N4O2S/c1-14-11-15(2)25-23(29)19(14)12-24-22(28)20-13-30-21(16(20)3)17(4)27-9-7-18(8-10-27)26(5)6/h11,13,17-18H,7-10,12H2,1-6H3,(H,24,28)(H,25,29)
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n/an/a 63n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259378
PNG
(US9505745, 55 | US9790212, Example 55)
Show SMILES CCN(C1CCOCC1)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H28N4O3S/c1-5-26(16-6-8-29-9-7-16)22-15(4)19(18(11-23)30-22)21(28)24-12-17-13(2)10-14(3)25-20(17)27/h10,16H,5-9,12H2,1-4H3,(H,24,28)(H,25,27)
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n/an/a 79n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259391
PNG
(US9505745, 68 | US9790212, Example 68)
Show SMILES Cc1c(csc1N1CCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H32N4O2S/c1-14-11-15(2)26-22(29)18(14)12-25-21(28)19-13-30-23(16(19)3)27-10-4-5-20(27)17-6-8-24-9-7-17/h11,13,17,20,24H,4-10,12H2,1-3H3,(H,25,28)(H,26,29)
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n/an/a 79n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259338
PNG
(US9505745, 15 | US9790212, Example 15)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29)
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n/an/a 79n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259401
PNG
(US9505745, 78 | US9790212, Example 78)
Show SMILES CCN(C1CCOCC1)c1sc(-c2cnn(C)c2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H33N5O3S/c1-6-30(19-7-9-33-10-8-19)25-17(4)21(22(34-25)18-12-27-29(5)14-18)24(32)26-13-20-15(2)11-16(3)28-23(20)31/h11-12,14,19H,6-10,13H2,1-5H3,(H,26,32)(H,28,31)
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n/an/a 100n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259326
PNG
(US9505745, 3 | US9790212, Example 3)
Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
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n/an/a 100n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259393
PNG
(US9505745, 70 | US9790212, Example 70)
Show SMILES Cc1c(csc1-c1cccc2CNCCc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H25N3O2S/c1-13-9-14(2)26-23(28)19(13)11-25-22(27)20-12-29-21(15(20)3)18-6-4-5-16-10-24-8-7-17(16)18/h4-6,9,12,24H,7-8,10-11H2,1-3H3,(H,25,27)(H,26,28)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259357
PNG
(US9505745, 34 | US9790212, Example 35)
Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C28H39N3O4S/c1-8-21(19-9-11-20(12-10-19)31-27(34)35-28(5,6)7)24-18(4)23(15-36-24)25(32)29-14-22-16(2)13-17(3)30-26(22)33/h8,13,15,19-20H,9-12,14H2,1-7H3,(H,29,32)(H,30,33)(H,31,34)/b21-8+/t19-,20-
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347696
PNG
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Show SMILES Cc1c(csc1C(O)C1CCN(CC1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C25H35N3O5S/c1-14-11-15(2)27-23(31)18(14)12-26-22(30)19-13-34-21(16(19)3)20(29)17-7-9-28(10-8-17)24(32)33-25(4,5)6/h11,13,17,20,29H,7-10,12H2,1-6H3,(H,26,30)(H,27,31)
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n/an/a 100n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259354
PNG
(US9505745, 31 | US9790212, Example 31)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259348
PNG
(US9505745, 25 | US9790212, Example 25)
Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C19H25N3O2S/c1-11-8-12(2)21-18(24)15(11)9-20-17(23)16-10-25-19(14(16)4)22-7-5-6-13(22)3/h8,10,13H,5-7,9H2,1-4H3,(H,20,23)(H,21,24)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259396
PNG
(US9505745, 73 | US9790212, Example 73)
Show SMILES CCC(CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-6-20(8-7-9-29-12-10-28(5)11-13-29)23-19(4)22(16-32-23)24(30)26-15-21-17(2)14-18(3)27-25(21)31/h14,16,20H,6-13,15H2,1-5H3,(H,26,30)(H,27,31)
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n/an/a 126n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259372
PNG
(US9505745, 49 | US9790212, Example 49)
Show SMILES Cc1c(csc1C(=C)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H27N3O2S/c1-12-9-13(2)24-21(26)17(12)10-23-20(25)18-11-27-19(15(18)4)14(3)16-5-7-22-8-6-16/h9,11,16,22H,3,5-8,10H2,1-2,4H3,(H,23,25)(H,24,26)
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n/an/a 126n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259361
PNG
(US9505745, 38 | US9790212, Example 38)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)C(O)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H33N3O3S/c1-13-10-14(2)25-23(29)18(13)11-24-22(28)19-12-30-21(15(19)3)20(27)16-6-8-17(9-7-16)26(4)5/h10,12,16-17,20,27H,6-9,11H2,1-5H3,(H,24,28)(H,25,29)/t16-,17-,20?
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n/an/a 158n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259343
PNG
(US9505745, 20 | US9790212, Example 20)
Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C
Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3
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n/an/a 158n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259388
PNG
(US9505745, 65 | US9790212, Example 65)
Show SMILES CCOC(=O)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C19H25N3O4S/c1-6-22(19(25)26-7-2)18-13(5)15(10-27-18)16(23)20-9-14-11(3)8-12(4)21-17(14)24/h8,10H,6-7,9H2,1-5H3,(H,20,23)(H,21,24)
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n/an/a 200n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259326
PNG
(US9505745, 3 | US9790212, Example 3)
Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
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n/an/a 200n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347749
PNG
((Z)-N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C\C=C(\CCCN1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H40N4O2S/c1-7-21(9-8-12-31-13-10-22(11-14-31)30(5)6)25-20(4)24(17-34-25)26(32)28-16-23-18(2)15-19(3)29-27(23)33/h7,15,17,22H,8-14,16H2,1-6H3,(H,28,32)(H,29,33)/b21-7-
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n/an/a 200n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259325
PNG
(US9505745, 2 | US9790212, Example 2)
Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25)
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n/an/a 200n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259380
PNG
(US9505745, 57 | US9790212, Example 58)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C30H44N4O5S/c1-8-34(22-10-13-38-14-11-22)28-20(4)24(27(36)31-16-23-18(2)15-19(3)32-26(23)35)25(40-28)21-9-12-33(17-21)29(37)39-30(5,6)7/h15,21-22H,8-14,16-17H2,1-7H3,(H,31,36)(H,32,35)
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n/an/a 200n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259347
PNG
(US9505745, 24 | US9790212, Example 24)
Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O4S/c1-13-9-14(2)25-21(28)17(13)10-24-20(27)18-12-31-19(15(18)3)16-7-8-26(11-16)22(29)30-23(4,5)6/h9,12,16H,7-8,10-11H2,1-6H3,(H,24,27)(H,25,28)
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n/an/a 251n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347747
PNG
((Z)-N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C\C=C(\CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H36N4O2S/c1-6-20(8-7-9-29-12-10-28(5)11-13-29)23-19(4)22(16-32-23)24(30)26-15-21-17(2)14-18(3)27-25(21)31/h6,14,16H,7-13,15H2,1-5H3,(H,26,30)(H,27,31)/b20-6-
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n/an/a 251n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259382
PNG
(US9505745, 59 | US9790212, Example 59)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C31H46N4O5S/c1-8-35(23-11-15-39-16-12-23)29-21(4)25(28(37)32-18-24-19(2)17-20(3)33-27(24)36)26(41-29)22-9-13-34(14-10-22)30(38)40-31(5,6)7/h17,22-23H,8-16,18H2,1-7H3,(H,32,37)(H,33,36)
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259336
PNG
(US9505745, 13 | US9790212, Example 13)
Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H32N4O2S/c1-14-10-15(2)24-22(28)19(14)12-23-21(27)17-11-20(29-13-17)16(3)26-8-6-18(7-9-26)25(4)5/h10-11,13,16,18H,6-9,12H2,1-5H3,(H,23,27)(H,24,28)
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259365
PNG
(US9505745, 42 | US9790212, Example 42)
Show SMILES CC[C@@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t21-/m1/s1
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259375
PNG
(US9505745, 52 | US9790212, Example 52)
Show SMILES CCN(CC)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C18H24BrN3O2S/c1-6-22(7-2)18-12(5)14(15(19)25-18)17(24)20-9-13-10(3)8-11(4)21-16(13)23/h8H,6-7,9H2,1-5H3,(H,20,24)(H,21,23)
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347696
PNG
(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Show SMILES Cc1c(csc1C(O)C1CCN(CC1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C25H35N3O5S/c1-14-11-15(2)27-23(31)18(14)12-26-22(30)19-13-34-21(16(19)3)20(29)17-7-9-28(10-8-17)24(32)33-25(4,5)6/h11,13,17,20,29H,7-10,12H2,1-6H3,(H,26,30)(H,27,31)
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259369
PNG
(US9505745, 46 | US9505745, 47 | US9790212, Example...)
Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19+,20?
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259340
PNG
(US9505745, 17 | US9790212, Example 17)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C24H33F3N4O2S/c1-6-31(17-9-7-16(8-10-17)30(4)5)23-15(3)19(13-34-23)21(32)28-12-18-14(2)11-20(24(25,26)27)29-22(18)33/h11,13,16-17H,6-10,12H2,1-5H3,(H,28,32)(H,29,33)/t16-,17-
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n/an/a 316n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259352
PNG
(US9505745, 29 | US9790212, Example 29)
Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-18(24-6-8-27-9-7-24)19-15(4)17(12-28-19)20(25)22-11-16-13(2)10-14(3)23-21(16)26/h10,12,18H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
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n/an/a 398n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259345
PNG
(US9505745, 22 | US9790212, Example 22)
Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O3S/c1-14-11-15(2)25-23(28)18(14)12-24-22(27)19-13-30-21(16(19)3)20-5-4-8-26(20)17-6-9-29-10-7-17/h11,13,17,20H,4-10,12H2,1-3H3,(H,24,27)(H,25,28)
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259346
PNG
(US9505745, 23 | US9790212, Example 23)
Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29)
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259384
PNG
(US9505745, 61 | US9790212, Example 61)
Show SMILES CCN(C1CCOCC1)c1sc(c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CCN(C)CC1
Show InChI InChI=1S/C27H38N4O3S/c1-6-31(21-9-13-34-14-10-21)27-19(4)23(24(35-27)20-7-11-30(5)12-8-20)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h7,15,21H,6,8-14,16H2,1-5H3,(H,28,33)(H,29,32)
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259385
PNG
(US9505745, 62 | US9790212, Example 62)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O5S2/c1-6-30(20-8-11-35-12-9-20)26-18(4)22(23(36-26)19-7-10-29(15-19)37(5,33)34)25(32)27-14-21-16(2)13-17(3)28-24(21)31/h13,19-20H,6-12,14-15H2,1-5H3,(H,27,32)(H,28,31)
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259386
PNG
(US9505745, 63 | US9790212, Example 63)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H40N4O5S2/c1-6-31(21-9-13-36-14-10-21)27-19(4)23(24(37-27)20-7-11-30(12-8-20)38(5,34)35)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h15,20-21H,6-14,16H2,1-5H3,(H,28,33)(H,29,32)
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259392
PNG
(US9505745, 69 | US9790212, Example 69)
Show SMILES Cc1c(csc1N1CCCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C24H34N4O2S/c1-15-12-16(2)27-23(30)19(15)13-26-22(29)20-14-31-24(17(20)3)28-11-5-4-6-21(28)18-7-9-25-10-8-18/h12,14,18,21,25H,4-11,13H2,1-3H3,(H,26,29)(H,27,30)
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259360
PNG
(US9505745, 37 | US9790212, Example 37)
Show SMILES Cc1c(csc1C(O)[C@H]1CC[C@H](N)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H29N3O3S/c1-11-8-12(2)24-21(27)16(11)9-23-20(26)17-10-28-19(13(17)3)18(25)14-4-6-15(22)7-5-14/h8,10,14-15,18,25H,4-7,9,22H2,1-3H3,(H,23,26)(H,24,27)/t14-,15-,18?
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259379
PNG
(US9505745, 56 | US9790212, Example 56)
Show SMILES CCN(C1CCOCC1)c1sc(N2CCN(C)CC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H39N5O3S/c1-6-31(20-7-13-34-14-8-20)25-19(4)22(26(35-25)30-11-9-29(5)10-12-30)24(33)27-16-21-17(2)15-18(3)28-23(21)32/h15,20H,6-14,16H2,1-5H3,(H,27,33)(H,28,32)
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n/an/a 501n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259338
PNG
(US9505745, 15 | US9790212, Example 15)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29)
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n/an/a 630n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259349
PNG
(US9505745, 26 | US9790212, Example 26)
Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C20H27N3O3S/c1-12-9-13(2)22-20(25)16(12)10-21-19(24)17-11-27-18(14(17)3)15(4)23-5-7-26-8-6-23/h9,11,15H,5-8,10H2,1-4H3,(H,21,24)(H,22,25)
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n/an/a 630n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259337
PNG
(US9505745, 14 | US9790212, Example 14)
Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27)
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n/an/a 630n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259340
PNG
(US9505745, 17 | US9790212, Example 17)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C24H33F3N4O2S/c1-6-31(17-9-7-16(8-10-17)30(4)5)23-15(3)19(13-34-23)21(32)28-12-18-14(2)11-20(24(25,26)27)29-22(18)33/h11,13,16-17H,6-10,12H2,1-5H3,(H,28,32)(H,29,33)/t16-,17-
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n/an/a 630n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259348
PNG
(US9505745, 25 | US9790212, Example 25)
Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C19H25N3O2S/c1-11-8-12(2)21-18(24)15(11)9-20-17(23)16-10-25-19(14(16)4)22-7-5-6-13(22)3/h8,10,13H,5-7,9H2,1-4H3,(H,20,23)(H,21,24)
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n/an/a 630n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259383
PNG
(US9505745, 60 | US9790212, Example 60)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCNCC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O3S/c1-5-30(20-8-12-33-13-9-20)26-18(4)22(23(34-26)19-6-10-27-11-7-19)25(32)28-15-21-16(2)14-17(3)29-24(21)31/h14,19-20,27H,5-13,15H2,1-4H3,(H,28,32)(H,29,31)
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n/an/a 631n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259380
PNG
(US9505745, 57 | US9790212, Example 58)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C30H44N4O5S/c1-8-34(22-10-13-38-14-11-22)28-20(4)24(27(36)31-16-23-18(2)15-19(3)32-26(23)35)25(40-28)21-9-12-33(17-21)29(37)39-30(5,6)7/h15,21-22H,8-14,16-17H2,1-7H3,(H,31,36)(H,32,35)
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n/an/a 794n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259354
PNG
(US9505745, 31 | US9790212, Example 31)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26)
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n/an/a 794n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM347746
PNG
((Z)-N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C\C=C(\CCN1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H31N3O3S/c1-5-18(6-7-26-8-10-29-11-9-26)21-17(4)20(14-30-21)22(27)24-13-19-15(2)12-16(3)25-23(19)28/h5,12,14H,6-11,13H2,1-4H3,(H,24,27)(H,25,28)/b18-5-
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n/an/a 1.00E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259343
PNG
(US9505745, 20 | US9790212, Example 20)
Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C
Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259337
PNG
(US9505745, 14 | US9790212, Example 14)
Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27)
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n/an/a 2.00E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259336
PNG
(US9505745, 13 | US9790212, Example 13)
Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H32N4O2S/c1-14-10-15(2)24-22(28)19(14)12-23-21(27)17-11-20(29-13-17)16(3)26-8-6-18(7-9-26)25(4)5/h10-11,13,16,18H,6-9,12H2,1-5H3,(H,23,27)(H,24,28)
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n/an/a 2.00E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259324
PNG
(US9505745, 1 | US9790212, Example 1)
Show SMILES CC(C)Oc1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20)
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n/an/a 3.16E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259352
PNG
(US9505745, 29 | US9790212, Example 29)
Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-18(24-6-8-27-9-7-24)19-15(4)17(12-28-19)20(25)22-11-16-13(2)10-14(3)23-21(16)26/h10,12,18H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
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US Patent
n/an/a 3.16E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259347
PNG
(US9505745, 24 | US9790212, Example 24)
Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O4S/c1-13-9-14(2)25-21(28)17(13)10-24-20(27)18-12-31-19(15(18)3)16-7-8-26(11-16)22(29)30-23(4,5)6/h9,12,16H,7-8,10-11H2,1-6H3,(H,24,27)(H,25,28)
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n/an/a 3.98E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259346
PNG
(US9505745, 23 | US9790212, Example 23)
Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29)
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n/an/a 3.98E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259349
PNG
(US9505745, 26 | US9790212, Example 26)
Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C20H27N3O3S/c1-12-9-13(2)22-20(25)16(12)10-21-19(24)17-11-27-18(14(17)3)15(4)23-5-7-26-8-6-23/h9,11,15H,5-8,10H2,1-4H3,(H,21,24)(H,22,25)
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n/an/a 5.01E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259345
PNG
(US9505745, 22 | US9790212, Example 22)
Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O3S/c1-14-11-15(2)25-23(28)18(14)12-24-22(27)19-13-30-21(16(19)3)20-5-4-8-26(20)17-6-9-29-10-7-17/h11,13,17,20H,4-10,12H2,1-3H3,(H,24,27)(H,25,28)
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n/an/a 6.31E+3n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259333
PNG
(US9505745, 10 | US9790212, Example 10)
Show SMILES Cc1c(cnn1CC1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H26N4O3/c1-12-8-13(2)22-19(25)16(12)9-20-18(24)17-10-21-23(14(17)3)11-15-4-6-26-7-5-15/h8,10,15H,4-7,9,11H2,1-3H3,(H,20,24)(H,22,25)
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n/an/a 1.58E+4n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259332
PNG
(US9505745, 9 | US9790212, Example 9)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H20N4O2/c1-12-9-13(2)22-19(25)16(12)10-20-18(24)17-11-21-23(14(17)3)15-7-5-4-6-8-15/h4-9,11H,10H2,1-3H3,(H,20,24)(H,22,25)
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n/an/a 2.00E+4n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259324
PNG
(US9505745, 1 | US9790212, Example 1)
Show SMILES CC(C)Oc1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20)
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n/an/a 2.51E+4n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259353
PNG
(US9505745, 30 | US9790212, Example 30)
Show SMILES CCN(C1CCOCC1)c1ccc(s1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H27N3O3S/c1-4-23(15-7-9-26-10-8-15)18-6-5-17(27-18)20(25)21-12-16-13(2)11-14(3)22-19(16)24/h5-6,11,15H,4,7-10,12H2,1-3H3,(H,21,25)(H,22,24)
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n/an/a 3.98E+4n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259332
PNG
(US9505745, 9 | US9790212, Example 9)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H20N4O2/c1-12-9-13(2)22-19(25)16(12)10-20-18(24)17-11-21-23(14(17)3)15-7-5-4-6-8-15/h4-9,11H,10H2,1-3H3,(H,20,24)(H,22,25)
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n/an/a 6.31E+4n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259353
PNG
(US9505745, 30 | US9790212, Example 30)
Show SMILES CCN(C1CCOCC1)c1ccc(s1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H27N3O3S/c1-4-23(15-7-9-26-10-8-15)18-6-5-17(27-18)20(25)21-12-16-13(2)11-14(3)22-19(16)24/h5-6,11,15H,4,7-10,12H2,1-3H3,(H,21,25)(H,22,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
PRC2 complex


(Homo sapiens (Human))
BDBM259333
PNG
(US9505745, 10 | US9790212, Example 10)
Show SMILES Cc1c(cnn1CC1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H26N4O3/c1-12-8-13(2)22-19(25)16(12)9-20-18(24)17-10-21-23(14(17)3)11-15-4-6-26-7-5-15/h8,10,15H,4-7,9,11H2,1-3H3,(H,20,24)(H,22,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

US Patent


Assay Description
Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...


US Patent US9790212 (2017)


BindingDB Entry DOI: 10.7270/Q2PZ5BZ2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%