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Patent code US9790228

Compile Data Set for Download or QSAR

Found 640 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348228
PNG
(US9790228, Compound 147)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3N3CCCC3)nc(-c3ccc4cc[nH]c4c3)c12
Show InChI InChI=1S/C27H24N8/c28-25-23-24(19-8-7-17-9-10-29-22(17)14-19)33-35(27(23)31-16-30-25)15-20-13-18-5-1-2-6-21(18)32-26(20)34-11-3-4-12-34/h1-2,5-10,13-14,16,29H,3-4,11-12,15H2,(H2,28,30,31)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348138
PNG
(US9790228, Compound 149 | US9790228, Compound 57)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3ccccc3)nc(-c3cc(O)cc(F)c3)c12
Show InChI InChI=1S/C27H19FN6O/c28-20-11-18(12-21(35)13-20)25-23-26(29)30-15-31-27(23)34(33-25)14-19-10-17-8-4-5-9-22(17)32-24(19)16-6-2-1-3-7-16/h1-13,15,35H,14H2,(H2,29,30,31)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348231
PNG
(US9790228, Compound 150)
Show SMILES CC(C)N(C)c1nc2ccccc2cc1Cn1nc(-c2cccc(O)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H25N7O/c1-15(2)31(3)24-18(11-16-7-4-5-10-20(16)29-24)13-32-25-21(23(26)27-14-28-25)22(30-32)17-8-6-9-19(33)12-17/h4-12,14-15,33H,13H2,1-3H3,(H2,26,27,28)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348234
PNG
(US9790228, Compound 153)
Show SMILES Nc1nc2cc(ccc2[nH]1)-c1nn(Cc2cc3ccccc3nc2N2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C26H24N10/c27-23-21-22(16-7-8-19-20(12-16)33-26(28)32-19)34-36(25(21)30-14-29-23)13-17-11-15-5-1-2-6-18(15)31-24(17)35-9-3-4-10-35/h1-2,5-8,11-12,14H,3-4,9-10,13H2,(H2,27,29,30)(H3,28,32,33)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM348235
PNG
(US9790228, Compound 154)
Show SMILES CC(C)N(C)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(N)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H25N9S/c1-14(2)34(3)24-17(10-15-6-4-5-7-18(15)31-24)12-35-25-21(23(27)29-13-30-25)22(33-35)16-8-9-19-20(11-16)36-26(28)32-19/h4-11,13-14H,12H2,1-3H3,(H2,28,32)(H2,27,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348236
PNG
(US9790228, Compound 155)
Show SMILES Nc1nc2cc(ccc2[nH]1)-c1nn(Cc2cc3ccccc3nc2-c2ccccc2C(F)(F)F)c2ncnc(N)c12
Show InChI InChI=1S/C29H20F3N9/c30-29(31,32)19-7-3-2-6-18(19)24-17(11-15-5-1-4-8-20(15)37-24)13-41-27-23(26(33)35-14-36-27)25(40-41)16-9-10-21-22(12-16)39-28(34)38-21/h1-12,14H,13H2,(H2,33,35,36)(H3,34,38,39)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348252
PNG
(US9790228, Compound 171)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2-n2cnc(C)c2)c2ncnc(N)c12
Show InChI InChI=1S/C28H22N10OS/c1-15-11-37(14-32-15)26-19(9-17-5-3-4-6-20(17)34-26)12-38-27-23(25(29)30-13-31-27)24(36-38)18-7-8-21-22(10-18)40-28(35-21)33-16(2)39/h3-11,13-14H,12H2,1-2H3,(H2,29,30,31)(H,33,35,39)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348089
PNG
(US9790228, Compound 8)
Show SMILES Cc1ccccc1-c1nc2c(C)cccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C29H23FN6O/c1-16-6-3-4-9-23(16)26-20(10-18-8-5-7-17(2)25(18)34-26)14-36-29-24(28(31)32-15-33-29)27(35-36)19-11-21(30)13-22(37)12-19/h3-13,15,37H,14H2,1-2H3,(H2,31,32,33)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348265
PNG
(US9790228, Compound 184)
Show SMILES CC(C)N(C)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(N)[nH]c3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H26N10/c1-14(2)35(3)24-17(10-15-6-4-5-7-18(15)31-24)12-36-25-21(23(27)29-13-30-25)22(34-36)16-8-9-19-20(11-16)33-26(28)32-19/h4-11,13-14H,12H2,1-3H3,(H2,27,29,30)(H3,28,32,33)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348280
PNG
(US9790228, Compound 199)
Show SMILES CN1CCN(CC1)c1nc2ccccc2nc1Cn1nc(-c2ccc3nc(N)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H25N11S/c1-35-8-10-36(11-9-35)24-19(31-16-4-2-3-5-17(16)32-24)13-37-25-21(23(27)29-14-30-25)22(34-37)15-6-7-18-20(12-15)38-26(28)33-18/h2-7,12,14H,8-11,13H2,1H3,(H2,28,33)(H2,27,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348120
PNG
(US9790228, Compound 39)
Show SMILES CCC(c1cc2ccccc2nc1N1CCCC1)n1nc(-c2cccc(O)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H27N7O/c1-2-22(20-15-17-8-3-4-11-21(17)31-26(20)33-12-5-6-13-33)34-27-23(25(28)29-16-30-27)24(32-34)18-9-7-10-19(35)14-18/h3-4,7-11,14-16,22,35H,2,5-6,12-13H2,1H3,(H2,28,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348124
PNG
(US9790228, Compound 43)
Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cccc(O)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H26N8O/c1-32-9-11-33(12-10-32)25-19(13-17-5-2-3-8-21(17)30-25)15-34-26-22(24(27)28-16-29-26)23(31-34)18-6-4-7-20(35)14-18/h2-8,13-14,16,35H,9-12,15H2,1H3,(H2,27,28,29)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348142
PNG
(US9790228, Compound 61)
Show SMILES Nc1ncnc2n(Cc3cnc4ccccc4c3)nc(-c3cc(O)cc(F)c3)c12
Show InChI InChI=1S/C21H15FN6O/c22-15-6-14(7-16(29)8-15)19-18-20(23)25-11-26-21(18)28(27-19)10-12-5-13-3-1-2-4-17(13)24-9-12/h1-9,11,29H,10H2,(H2,23,25,26)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348146
PNG
(US9790228, Compound 65)
Show SMILES Cc1cccc2cc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)c(nc12)N1CCOCC1
Show InChI InChI=1S/C26H24FN7O2/c1-15-3-2-4-16-9-18(25(31-22(15)16)33-5-7-36-8-6-33)13-34-26-21(24(28)29-14-30-26)23(32-34)17-10-19(27)12-20(35)11-17/h2-4,9-12,14,35H,5-8,13H2,1H3,(H2,28,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348173
PNG
(US9790228, Compound 92)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2-c2ccccc2)c2ncnc(N)c12
Show InChI InChI=1S/C30H22N8OS/c1-17(39)34-30-36-23-12-11-20(14-24(23)40-30)27-25-28(31)32-16-33-29(25)38(37-27)15-21-13-19-9-5-6-10-22(19)35-26(21)18-7-3-2-4-8-18/h2-14,16H,15H2,1H3,(H2,31,32,33)(H,34,36,39)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348194
PNG
(US9790228, Compound 113)
Show SMILES CCn1c2ccccc2cc(Cn2nc(-c3cc(O)cc(F)c3)c3c(N)ncnc23)c1=O
Show InChI InChI=1S/C23H19FN6O2/c1-2-29-18-6-4-3-5-13(18)7-15(23(29)32)11-30-22-19(21(25)26-12-27-22)20(28-30)14-8-16(24)10-17(31)9-14/h3-10,12,31H,2,11H2,1H3,(H2,25,26,27)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348208
PNG
(US9790228, Compound 127)
Show SMILES Cc1ccccc1-c1nc2ccccc2n1CCn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H22FN7O/c1-16-6-2-3-7-20(16)26-32-21-8-4-5-9-22(21)34(26)10-11-35-27-23(25(29)30-15-31-27)24(33-35)17-12-18(28)14-19(36)13-17/h2-9,12-15,36H,10-11H2,1H3,(H2,29,30,31)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM348211
PNG
(US9790228, Compound 130)
Show SMILES CN(C)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(NC(C)=O)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H23N9OS/c1-14(36)30-26-32-19-9-8-16(11-20(19)37-26)22-21-23(27)28-13-29-25(21)35(33-22)12-17-10-15-6-4-5-7-18(15)31-24(17)34(2)3/h4-11,13H,12H2,1-3H3,(H2,27,28,29)(H,30,32,36)
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n/an/a<100n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348213
PNG
(US9790228, Compound 132)
Show SMILES Cc1ccccc1-c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(N)ncc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C30H23N9/c1-17-6-2-4-8-22(17)26-21(12-18-7-3-5-9-23(18)36-26)15-39-29-25(28(31)34-16-35-29)27(38-39)19-10-11-24-20(13-19)14-33-30(32)37-24/h2-14,16H,15H2,1H3,(H2,31,34,35)(H2,32,33,37)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348217
PNG
(US9790228, Compound 136)
Show SMILES Nc1ccc2cc(ccc2n1)-c1nn(Cc2cc3ccccc3nc2-c2ccccc2F)c2ncnc(N)c12
Show InChI InChI=1S/C30H21FN8/c31-22-7-3-2-6-21(22)27-20(14-17-5-1-4-8-23(17)37-27)15-39-30-26(29(33)34-16-35-30)28(38-39)19-9-11-24-18(13-19)10-12-25(32)36-24/h1-14,16H,15H2,(H2,32,36)(H2,33,34,35)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348232
PNG
(US9790228, Compound 151)
Show SMILES CC(C)N(C)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(NC(C)=O)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H27N9OS/c1-15(2)36(4)26-19(11-17-7-5-6-8-20(17)33-26)13-37-27-23(25(29)30-14-31-27)24(35-37)18-9-10-21-22(12-18)39-28(34-21)32-16(3)38/h5-12,14-15H,13H2,1-4H3,(H2,29,30,31)(H,32,34,38)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348234
PNG
(US9790228, Compound 153)
Show SMILES Nc1nc2cc(ccc2[nH]1)-c1nn(Cc2cc3ccccc3nc2N2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C26H24N10/c27-23-21-22(16-7-8-19-20(12-16)33-26(28)32-19)34-36(25(21)30-14-29-23)13-17-11-15-5-1-2-6-18(15)31-24(17)35-9-3-4-10-35/h1-2,5-8,11-12,14H,3-4,9-10,13H2,(H2,27,29,30)(H3,28,32,33)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM348244
PNG
(US9790228, Compound 163)
Show SMILES CC(C)N1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(NC(C)=O)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C31H32N10OS/c1-18(2)39-10-12-40(13-11-39)29-22(14-20-6-4-5-7-23(20)36-29)16-41-30-26(28(32)33-17-34-30)27(38-41)21-8-9-24-25(15-21)43-31(37-24)35-19(3)42/h4-9,14-15,17-18H,10-13,16H2,1-3H3,(H2,32,33,34)(H,35,37,42)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348247
PNG
(US9790228, Compound 166)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2CCN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C30H29N9OS/c1-18(40)34-30-36-24-9-8-20(15-25(24)41-30)27-26-28(31)32-17-33-29(26)39(37-27)16-21-14-19-6-2-3-7-22(19)35-23(21)10-13-38-11-4-5-12-38/h2-3,6-9,14-15,17H,4-5,10-13,16H2,1H3,(H2,31,32,33)(H,34,36,40)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348261
PNG
(US9790228, Compound 180)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3ccccc3)nc(-c3cn[nH]c3)c12
Show InChI InChI=1S/C24H18N8/c25-23-20-22(18-11-28-29-12-18)31-32(24(20)27-14-26-23)13-17-10-16-8-4-5-9-19(16)30-21(17)15-6-2-1-3-7-15/h1-12,14H,13H2,(H,28,29)(H2,25,26,27)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348082
PNG
(US9790228, Compound 1)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3N3CCCC3)nc(I)c12
Show InChI InChI=1S/C19H18IN7/c20-16-15-17(21)22-11-23-19(15)27(25-16)10-13-9-12-5-1-2-6-14(12)24-18(13)26-7-3-4-8-26/h1-2,5-6,9,11H,3-4,7-8,10H2,(H2,21,22,23)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348085
PNG
(US9790228, Compound 4)
Show SMILES Cc1ccccc1-c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H21FN6O/c1-16-6-2-4-8-22(16)25-19(10-17-7-3-5-9-23(17)33-25)14-35-28-24(27(30)31-15-32-28)26(34-35)18-11-20(29)13-21(36)12-18/h2-13,15,36H,14H2,1H3,(H2,30,31,32)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348086
PNG
(US9790228, Compound 5)
Show SMILES Cc1ccccc1-c1nc2ccccc2cc1Cn1nc(-c2cccc(O)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H22N6O/c1-17-7-2-4-11-22(17)25-20(13-18-8-3-5-12-23(18)32-25)15-34-28-24(27(29)30-16-31-28)26(33-34)19-9-6-10-21(35)14-19/h2-14,16,35H,15H2,1H3,(H2,29,30,31)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348090
PNG
(US9790228, Compound 9)
Show SMILES Cc1cccc2cc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)c(nc12)N1CCCC1
Show InChI InChI=1S/C26H24FN7O/c1-15-5-4-6-16-9-18(25(31-22(15)16)33-7-2-3-8-33)13-34-26-21(24(28)29-14-30-26)23(32-34)17-10-19(27)12-20(35)11-17/h4-6,9-12,14,35H,2-3,7-8,13H2,1H3,(H2,28,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348096
PNG
(US9790228, Compound 15)
Show SMILES COc1ccccc1-c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H21FN6O2/c1-37-23-9-5-3-7-21(23)25-18(10-16-6-2-4-8-22(16)33-25)14-35-28-24(27(30)31-15-32-28)26(34-35)17-11-19(29)13-20(36)12-17/h2-13,15,36H,14H2,1H3,(H2,30,31,32)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348131
PNG
(US9790228, Compound 197 | US9790228, Compound 50)
Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348089
PNG
(US9790228, Compound 8)
Show SMILES Cc1ccccc1-c1nc2c(C)cccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C29H23FN6O/c1-16-6-3-4-9-23(16)26-20(10-18-8-5-7-17(2)25(18)34-26)14-36-29-24(28(31)32-15-33-29)27(35-36)19-11-21(30)13-22(37)12-19/h3-13,15,37H,14H2,1-2H3,(H2,31,32,33)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348266
PNG
(US9790228, Compound 185)
Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(NC(C)=O)[nH]c3c2)c2c(N)ncnc12
Show InChI InChI=1S/C29H29N11O/c1-17(41)33-29-35-22-8-7-19(14-23(22)36-29)25-24-26(30)31-16-32-28(24)40(37-25)15-20-13-18-5-3-4-6-21(18)34-27(20)39-11-9-38(2)10-12-39/h3-8,13-14,16H,9-12,15H2,1-2H3,(H2,30,31,32)(H2,33,35,36,41)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348091
PNG
(US9790228, Compound 10)
Show SMILES Cc1cccc2cc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)c(nc12)N1CCCC1
Show InChI InChI=1S/C26H25N7O/c1-16-6-4-7-17-12-19(25(30-22(16)17)32-10-2-3-11-32)14-33-26-21(24(27)28-15-29-26)23(31-33)18-8-5-9-20(34)13-18/h4-9,12-13,15,34H,2-3,10-11,14H2,1H3,(H2,27,28,29)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348092
PNG
(US9790228, Compound 11)
Show SMILES CN1CCN(CC1)c1nc2c(C)cccc2cc1Cn1nc(I)c2c(N)ncnc12
Show InChI InChI=1S/C21H23IN8/c1-13-4-3-5-14-10-15(20(26-17(13)14)29-8-6-28(2)7-9-29)11-30-21-16(18(22)27-30)19(23)24-12-25-21/h3-5,10,12H,6-9,11H2,1-2H3,(H2,23,24,25)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348111
PNG
(US9790228, Compound 30)
Show SMILES CC(c1cc2ccccc2nc1N1CCCC1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H24FN7O/c1-15(20-12-16-6-2-3-7-21(16)31-25(20)33-8-4-5-9-33)34-26-22(24(28)29-14-30-26)23(32-34)17-10-18(27)13-19(35)11-17/h2-3,6-7,10-15,35H,4-5,8-9H2,1H3,(H2,28,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348105
PNG
(US9790228, Compound 195 | US9790228, Compound 24)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2N2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C28H25N9OS/c1-16(38)32-28-34-21-9-8-18(13-22(21)39-28)24-23-25(29)30-15-31-27(23)37(35-24)14-19-12-17-6-2-3-7-20(17)33-26(19)36-10-4-5-11-36/h2-3,6-9,12-13,15H,4-5,10-11,14H2,1H3,(H2,29,30,31)(H,32,34,38)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348280
PNG
(US9790228, Compound 199)
Show SMILES CN1CCN(CC1)c1nc2ccccc2nc1Cn1nc(-c2ccc3nc(N)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H25N11S/c1-35-8-10-36(11-9-35)24-19(31-16-4-2-3-5-17(16)32-24)13-37-25-21(23(27)29-14-30-25)22(34-37)15-6-7-18-20(12-15)38-26(28)33-18/h2-7,12,14H,8-11,13H2,1H3,(H2,28,33)(H2,27,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348123
PNG
(US9790228, Compound 42)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3NC3CCC3)nc(-c3cc(O)cc(F)c3)c12
Show InChI InChI=1S/C25H22FN7O/c26-17-9-15(10-19(34)11-17)22-21-23(27)28-13-29-25(21)33(32-22)12-16-8-14-4-1-2-7-20(14)31-24(16)30-18-5-3-6-18/h1-2,4,7-11,13,18,34H,3,5-6,12H2,(H,30,31)(H2,27,28,29)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM348131
PNG
(US9790228, Compound 197 | US9790228, Compound 50)
Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM348137
PNG
(US9790228, Compound 56)
Show SMILES Cc1ccncc1-c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H20FN7O/c1-15-6-7-30-12-21(15)24-18(8-16-4-2-3-5-22(16)33-24)13-35-27-23(26(29)31-14-32-27)25(34-35)17-9-19(28)11-20(36)10-17/h2-12,14,36H,13H2,1H3,(H2,29,31,32)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348144
PNG
(US9790228, Compound 63)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3N3CCOCC3)nc(-c3cc(O)cc(F)c3)c12
Show InChI InChI=1S/C25H22FN7O2/c26-18-10-16(11-19(34)12-18)22-21-23(27)28-14-29-25(21)33(31-22)13-17-9-15-3-1-2-4-20(15)30-24(17)32-5-7-35-8-6-32/h1-4,9-12,14,34H,5-8,13H2,(H2,27,28,29)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348149
PNG
(US9790228, Compound 68)
Show SMILES CCN(CC)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H24FN7O/c1-3-32(4-2)24-17(9-15-7-5-6-8-20(15)30-24)13-33-25-21(23(27)28-14-29-25)22(31-33)16-10-18(26)12-19(34)11-16/h5-12,14,34H,3-4,13H2,1-2H3,(H2,27,28,29)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348179
PNG
(US9790228, Compound 98)
Show SMILES CCc1nc2ccccc2cc1Cn1nc(-c2ccc3nc(NC(C)=O)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H22N8OS/c1-3-18-17(10-15-6-4-5-7-19(15)31-18)12-34-25-22(24(27)28-13-29-25)23(33-34)16-8-9-20-21(11-16)36-26(32-20)30-14(2)35/h4-11,13H,3,12H2,1-2H3,(H2,27,28,29)(H,30,32,35)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348185
PNG
(US9790228, Compound 104)
Show SMILES Nc1ncnc2n(Cc3nc4ccccc4nc3N3CCCC3)nc(-c3cc(O)cc(F)c3)c12
Show InChI InChI=1S/C24H21FN8O/c25-15-9-14(10-16(34)11-15)21-20-22(26)27-13-28-24(20)33(31-21)12-19-23(32-7-3-4-8-32)30-18-6-2-1-5-17(18)29-19/h1-2,5-6,9-11,13,34H,3-4,7-8,12H2,(H2,26,27,28)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348186
PNG
(US9790228, Compound 105)
Show SMILES Nc1ncnc2n(Cc3nc4ccccc4nc3N3CCCC3)nc(-c3cccc(O)c3)c12
Show InChI InChI=1S/C24H22N8O/c25-22-20-21(15-6-5-7-16(33)12-15)30-32(24(20)27-14-26-22)13-19-23(31-10-3-4-11-31)29-18-9-2-1-8-17(18)28-19/h1-2,5-9,12,14,33H,3-4,10-11,13H2,(H2,25,26,27)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348188
PNG
(US9790228, Compound 107)
Show SMILES Cc1ccccc1-c1nc2ccccc2nc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H20FN7O/c1-15-6-2-3-7-19(15)25-22(32-20-8-4-5-9-21(20)33-25)13-35-27-23(26(29)30-14-31-27)24(34-35)16-10-17(28)12-18(36)11-16/h2-12,14,36H,13H2,1H3,(H2,29,30,31)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM348211
PNG
(US9790228, Compound 130)
Show SMILES CN(C)c1nc2ccccc2cc1Cn1nc(-c2ccc3nc(NC(C)=O)sc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H23N9OS/c1-14(36)30-26-32-19-9-8-16(11-20(19)37-26)22-21-23(27)28-13-29-25(21)35(33-22)12-17-10-15-6-4-5-7-18(15)31-24(17)34(2)3/h4-11,13H,12H2,1-3H3,(H2,27,28,29)(H,30,32,36)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348216
PNG
(US9790228, Compound 135)
Show SMILES Nc1ncc2cc(ccc2n1)-c1nn(Cc2cc3ccccc3nc2-c2ccccc2F)c2ncnc(N)c12
Show InChI InChI=1S/C29H20FN9/c30-21-7-3-2-6-20(21)25-19(11-16-5-1-4-8-22(16)36-25)14-39-28-24(27(31)34-15-35-28)26(38-39)17-9-10-23-18(12-17)13-33-29(32)37-23/h1-13,15H,14H2,(H2,31,34,35)(H2,32,33,37)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM348219
PNG
(US9790228, Compound 138)
Show SMILES Nc1ncnc2n(Cc3cc4ccccc4nc3-c3ccccc3F)nc(-c3ccc4ncnc(N)c4c3)c12
Show InChI InChI=1S/C29H20FN9/c30-21-7-3-2-6-19(21)25-18(11-16-5-1-4-8-22(16)37-25)13-39-29-24(28(32)35-15-36-29)26(38-39)17-9-10-23-20(12-17)27(31)34-14-33-23/h1-12,14-15H,13H2,(H2,31,33,34)(H2,32,35,36)
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Intellikine LLC

US Patent


Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...


US Patent US9790228 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 640 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%