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Patent code US9790233

Compile Data Set for Download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347359
PNG
(US9789116, SW033291)
Show SMILES CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
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US Patent
n/an/a 0.760n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347365
PNG
(US9789116, SW206992)
Show SMILES CCCCS(=O)c1sc2nc(ccc2c1N)-c1nccs1
Show InChI InChI=1S/C14H15N3OS3/c1-2-3-8-21(18)14-11(15)9-4-5-10(17-12(9)20-14)13-16-6-7-19-13/h4-7H,2-3,8,15H2,1H3
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n/an/a 0.970n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347359
PNG
(US9789116, SW033291)
Show SMILES CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
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n/an/a 1.23n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347368
PNG
(US9789116, SW208066)
Show SMILES CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1nccs1
Show InChI InChI=1S/C20H19N3OS3/c1-2-3-11-27(24)20-17(21)16-14(13-7-5-4-6-8-13)12-15(23-19(16)26-20)18-22-9-10-25-18/h4-10,12H,2-3,11,21H2,1H3
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n/an/a 1.37n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM348758
PNG
(US9790233, ID SW206992)
Show SMILES CCCCC(=O)c1sc2nc(ccc2c1N)-c1nccs1
Show InChI InChI=1S/C15H15N3OS2/c1-2-3-4-11(19)13-12(16)9-5-6-10(18-14(9)21-13)15-17-7-8-20-15/h5-8H,2-4,16H2,1H3
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n/an/a 1.41n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347369
PNG
(US9789116, SW208067)
Show SMILES CCCCS(=O)c1sc2nc(nc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C20H19N3OS3/c1-2-3-12-27(24)20-16(21)15-17(13-8-5-4-6-9-13)22-18(23-19(15)26-20)14-10-7-11-25-14/h4-11H,2-3,12,21H2,1H3
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n/an/a 2.40n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347375
PNG
(US9789116, SW208080)
Show SMILES CCCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C22H22N2OS3/c1-2-3-7-13-28(25)22-20(23)19-16(15-9-5-4-6-10-15)14-17(24-21(19)27-22)18-11-8-12-26-18/h4-6,8-12,14H,2-3,7,13,23H2,1H3
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n/an/a 2.64n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347367
PNG
(US9789116, SW208065)
Show SMILES CCCCS(=O)c1sc2nc(nc(-c3ccccc3)c2c1N)-c1ccccc1
Show InChI InChI=1S/C22H21N3OS2/c1-2-3-14-28(26)22-18(23)17-19(15-10-6-4-7-11-15)24-20(25-21(17)27-22)16-12-8-5-9-13-16/h4-13H,2-3,14,23H2,1H3
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n/an/a 4.87n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM348752
PNG
(US9790233, ID SW208081)
Show SMILES CCCCCCC(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C24H24N2OS2/c1-2-3-4-8-12-19(27)23-22(25)21-17(16-10-6-5-7-11-16)15-18(26-24(21)29-23)20-13-9-14-28-20/h5-7,9-11,13-15H,2-4,8,12,25H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347374
PNG
(US9789116, SW208078)
Show SMILES CCCCS(=O)(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C21H20N2O2S3/c1-2-3-12-28(24,25)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)27-21)17-10-7-11-26-17/h4-11,13H,2-3,12,22H2,1H3
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n/an/a 25n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347359
PNG
(US9789116, SW033291)
Show SMILES CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
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n/an/a 56.6n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM348749
PNG
(US9790233, ID SW208079)
Show SMILES CS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C18H14N2OS3/c1-24(21)18-16(19)15-12(11-6-3-2-4-7-11)10-13(20-17(15)23-18)14-8-5-9-22-14/h2-10H,19H2,1H3
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n/an/a 125n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347366
PNG
(US9789116, SW208064)
Show SMILES CCCCS(=O)c1sc2ncccc2c1N
Show InChI InChI=1S/C11H14N2OS2/c1-2-3-7-16(14)11-9(12)8-5-4-6-13-10(8)15-11/h4-6H,2-3,7,12H2,1H3
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n/an/a 151n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM53662
PNG
(2-Methanesulfonyl-4-phenyl-6-thiophen-2-yl-thieno[...)
Show SMILES CS(=O)(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C18H14N2O2S3/c1-25(21,22)18-16(19)15-12(11-6-3-2-4-7-11)10-13(20-17(15)24-18)14-8-5-9-23-14/h2-10H,19H2,1H3
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Article
US Patent
n/an/a 525n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347360
PNG
(US9789116, SW206976)
Show SMILES CCCCC(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C22H20N2OS2/c1-2-3-10-17(25)21-20(23)19-15(14-8-5-4-6-9-14)13-16(24-22(19)27-21)18-11-7-12-26-18/h4-9,11-13H,2-3,10,23H2,1H3
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347372
PNG
(US9789116, SW208070)
Show SMILES CCCCS(=O)c1ncccc1N
Show InChI InChI=1S/C9H14N2OS/c1-2-3-7-13(12)9-8(10)5-4-6-11-9/h4-6H,2-3,7,10H2,1H3
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347361
PNG
(US9789116, SW206977)
Show SMILES CCCNC(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C21H19N3OS2/c1-2-10-23-20(25)19-18(22)17-14(13-7-4-3-5-8-13)12-15(24-21(17)27-19)16-9-6-11-26-16/h3-9,11-12H,2,10,22H2,1H3,(H,23,25)
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM348764
PNG
(US9790233, ID SW208069)
Show SMILES CCCCS(=O)c1ncccc1N(=O)=O
Show InChI InChI=1S/C9H12N2O3S/c1-2-3-7-15(14)9-8(11(12)13)5-4-6-10-9/h4-6H,2-3,7H2,1H3
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347370
PNG
(US9789116, SW208068)
Show SMILES CCCCSc1ncccc1N
Show InChI InChI=1S/C9H14N2S/c1-2-3-7-12-9-8(10)5-4-6-11-9/h4-6H,2-3,7,10H2,1H3
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM348756
PNG
(US9790233, ID SW206979)
Show SMILES Nc1c(sc2nc(ccc12)-c1cccs1)C(O)=O
Show InChI InChI=1S/C12H8N2O2S2/c13-9-6-3-4-7(8-2-1-5-17-8)14-11(6)18-10(9)12(15)16/h1-5H,13H2,(H,15,16)
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM347362
PNG
(US9789116, SW206978)
Show SMILES CCOC(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Show InChI InChI=1S/C20H16N2O2S2/c1-2-24-20(23)18-17(21)16-13(12-7-4-3-5-8-12)11-14(22-19(16)26-18)15-9-6-10-25-15/h3-11H,2,21H2,1H3
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n/an/a>7.50E+3n/an/an/an/an/an/a



Case Western Reserve University; Board of Regents of the University of Texas System; University of Kentucky Research Foundation

US Patent


Assay Description
In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...


US Patent US9790233 (2017)


Article DOI: 10.1021/jm060882y
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%