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Patent code US9795606

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350851
PNG
(UNC2123A | US9795606, B10)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1S/C23H28FN5/c24-17-5-3-16(4-6-17)21-14-29(19-9-7-18(25)8-10-19)22-20(21)13-27-23(28-22)26-12-11-15-1-2-15/h3-6,13-15,18-19H,1-2,7-12,25H2,(H,26,27,28)/t18-,19?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350861
PNG
(UNC2371A | US9795606, B20)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
Show InChI InChI=1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350871
PNG
(UNC2433A | US9795606, D2)
Show SMILES CCCCNc1ncc2n(cc(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C27H37N5O3S/c1-2-3-15-28-27-29-18-25-26(30-27)24(20-7-11-22(33)12-8-20)19-32(25)21-9-13-23(14-10-21)36(34,35)31-16-5-4-6-17-31/h9-10,13-14,18-20,22,33H,2-8,11-12,15-17H2,1H3,(H,28,29,30)/t20?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350842
PNG
(UNC1970A | US9795606, B1)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H28FN5/c1-2-3-12-25-22-26-13-19-20(15-4-6-16(23)7-5-15)14-28(21(19)27-22)18-10-8-17(24)9-11-18/h4-7,13-14,17-18H,2-3,8-12,24H2,1H3,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350844
PNG
(UNC1972A | US9795606, B3)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C26H36N6O3S/c1-2-3-12-28-26-29-17-23-24(18-32(25(23)30-26)21-8-6-20(27)7-9-21)19-4-10-22(11-5-19)36(33,34)31-13-15-35-16-14-31/h4-5,10-11,17-18,20-21H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20-,21?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350866
PNG
(UNC1668A | US9795606, B27)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C26H34FN5O2/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)31-11-13-34-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350868
PNG
(UNC1670A | US9795606, B29)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C26H34FN5O4S/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)37(34,35)31-11-13-36-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350846
PNG
(UNC2026A | US9795606, B5)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1S/C27H36N4O4S/c1-2-3-14-28-27-29-17-24-25(18-31(26(24)30-27)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)23-12-15-35-16-13-23/h4-5,10-11,17-18,20-21,23,32H,2-3,6-9,12-16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350848
PNG
(UNC2078A | US9795606, B7)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C27H37N5O3S/c1-2-3-15-28-27-29-18-24-25(19-32(26(24)30-27)21-9-11-22(33)12-10-21)20-7-13-23(14-8-20)36(34,35)31-16-5-4-6-17-31/h7-8,13-14,18-19,21-22,33H,2-6,9-12,15-17H2,1H3,(H,28,29,30)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350849
PNG
(UNC2094A | US9795606, B8)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H26F2N4O/c1-2-3-10-25-22-26-12-17-18(14-4-9-19(23)20(24)11-14)13-28(21(17)27-22)15-5-7-16(29)8-6-15/h4,9,11-13,15-16,29H,2-3,5-8,10H2,1H3,(H,25,26,27)/t15?,16-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350852
PNG
(UNC2124A | US9795606, B11)
Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCCCO)nc12
Show InChI InChI=1S/C22H28FN5O/c23-16-5-3-15(4-6-16)20-14-28(18-9-7-17(24)8-10-18)21-19(20)13-26-22(27-21)25-11-1-2-12-29/h3-6,13-14,17-18,29H,1-2,7-12,24H2,(H,25,26,27)/t17-,18?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350855
PNG
(UNC2143A | US9795606, B14)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCNCC2)cc1
Show InChI InChI=1S/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(19-33(26(24)31-27)22-8-10-23(34)11-9-22)21-6-4-20(5-7-21)18-32-15-13-28-14-16-32/h4-7,17,19,22-23,28,34H,2-3,8-16,18H2,1H3,(H,29,30,31)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350839
PNG
(UNC1534A | US9795606, A3)
Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C28H41N7O2S/c1-3-4-13-30-28-31-18-25-26(20-34(27(25)32-28)19-21-5-9-23(29)10-6-21)22-7-11-24(12-8-22)38(36,37)35-16-14-33(2)15-17-35/h7-8,11-12,18,20-21,23H,3-6,9-10,13-17,19,29H2,1-2H3,(H,30,31,32)/t21-,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350841
PNG
(UNC1536A | US9795606, A5)
Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C27H37FN6O3S/c1-2-3-10-30-27-31-16-22-23(18-33(26(22)32-27)17-19-4-7-21(29)8-5-19)20-6-9-25(24(28)15-20)38(35,36)34-11-13-37-14-12-34/h6,9,15-16,18-19,21H,2-5,7-8,10-14,17,29H2,1H3,(H,30,31,32)/t19-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350850
PNG
(UNC2095A | US9795606, B9)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1
Show InChI InChI=1S/C27H35F2N5O3S/c1-2-3-14-30-26-31-17-23-24(18-34(25(23)32-26)20-6-8-21(35)9-7-20)19-4-10-22(11-5-19)38(36,37)33-15-12-27(28,29)13-16-33/h4-5,10-11,17-18,20-21,35H,2-3,6-9,12-16H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350854
PNG
(UNC2142A | US9795606, B13)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H37N5O2/c1-2-3-12-28-27-29-17-24-25(19-32(26(24)30-27)22-8-10-23(33)11-9-22)21-6-4-20(5-7-21)18-31-13-15-34-16-14-31/h4-7,17,19,22-23,33H,2-3,8-16,18H2,1H3,(H,28,29,30)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350857
PNG
(UNC2253A | US9795606, B16)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1
Show InChI InChI=1S/C29H39N5O2/c1-2-3-14-30-28-31-19-25-26(20-34(27(25)32-28)23-8-10-24(35)11-9-23)21-4-6-22(7-5-21)29(12-13-29)33-15-17-36-18-16-33/h4-7,19-20,23-24,35H,2-3,8-18H2,1H3,(H,30,31,32)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350862
PNG
(UNC1651A | US9795606, B23)
Show SMILES CC(C)(C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-27(2,3)35-26-33-15-21-22(16-38(25(21)34-26)19-5-7-20(39)8-6-19)18-4-9-24(23(29)14-18)42(40,41)37-12-10-36(11-13-37)17-28(30,31)32/h4,9,14-16,19-20,39H,5-8,10-13,17H2,1-3H3,(H,33,34,35)/t19-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350864
PNG
(UNC1666A | US9795606, B25)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C26H35N5O4S/c1-2-3-12-27-26-28-17-23-24(18-31(25(23)29-26)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17-18,20-21,32H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20-,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350865
PNG
(UNC1667A | US9795606, B26)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C27H38N6O3S/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)21-7-9-22(34)10-8-21)20-5-11-23(12-6-20)37(35,36)32-16-14-31(2)15-17-32/h5-6,11-12,18-19,21-22,34H,3-4,7-10,13-17H2,1-2H3,(H,28,29,30)/t21-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50055498
PNG
(CHEMBL3326004 | US9795606, B28)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21-
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n/an/a<250n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350840
PNG
(UNC1535A | US9795606, A4)
Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H32N6O2S/c1-2-3-12-26-23-27-13-20-21(17-6-10-19(11-7-17)32(25,30)31)15-29(22(20)28-23)14-16-4-8-18(24)9-5-16/h6-7,10-11,13,15-16,18H,2-5,8-9,12,14,24H2,1H3,(H2,25,30,31)(H,26,27,28)/t16-,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350856
PNG
(UNC2146A | US9795606, B15)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C25H31F2N5O3S/c1-2-3-12-28-24-29-13-21-22(14-32(23(21)30-24)18-6-8-19(33)9-7-18)17-4-10-20(11-5-17)36(34,35)31-15-25(26,27)16-31/h4-5,10-11,13-14,18-19,33H,2-3,6-9,12,15-16H2,1H3,(H,28,29,30)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350858
PNG
(UNC2367A | US9795606, B17)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1
Show InChI InChI=1S/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350859
PNG
(UNC2368A | US9795606, B18)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(cc2F)S(=O)(=O)N2CCOCC2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1S/C27H34FN5O4S/c28-25-15-21(38(35,36)32-11-13-37-14-12-32)7-8-22(25)24-17-33(19-3-5-20(34)6-4-19)26-23(24)16-30-27(31-26)29-10-9-18-1-2-18/h7-8,15-20,34H,1-6,9-14H2,(H,29,30,31)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350863
PNG
(UNC1652A | US9795606, B24)
Show SMILES CC(C)(C)Nc1ncc2c(cn([C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C28H36F4N6O3S/c1-27(2,3)35-26-33-15-21-22(16-38(25(21)34-26)19-5-7-20(39)8-6-19)18-4-9-24(23(29)14-18)42(40,41)37-12-10-36(11-13-37)17-28(30,31)32/h4,9,14-16,19-20,39H,5-8,10-13,17H2,1-3H3,(H,33,34,35)/t19-,20+
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350837
PNG
(UNC1532A | US9795606, A1)
Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(21-6-10-23(11-7-21)32-13-15-34-16-14-32)19-33(26(24)31-27)18-20-4-8-22(28)9-5-20/h6-7,10-11,17,19-20,22H,2-5,8-9,12-16,18,28H2,1H3,(H,29,30,31)/t20-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350838
PNG
(UNC1533A | US9795606, A2)
Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C27H39N7/c1-2-3-12-30-27-31-17-24-25(21-6-10-23(11-7-21)33-15-13-29-14-16-33)19-34(26(24)32-27)18-20-4-8-22(28)9-5-20/h6-7,10-11,17,19-20,22,29H,2-5,8-9,12-16,18,28H2,1H3,(H,30,31,32)/t20-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350845
PNG
(UNC2025A | US9795606, B4)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350847
PNG
(UNC2087A | US9795606, B6)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C27H36N4O3S/c1-2-3-16-28-27-29-17-24-25(18-31(26(24)30-27)20-10-12-21(32)13-11-20)19-8-14-23(15-9-19)35(33,34)22-6-4-5-7-22/h8-9,14-15,17-18,20-22,32H,2-7,10-13,16H2,1H3,(H,28,29,30)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350853
PNG
(UNC2125A | US9795606, B12)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H27F2N5/c1-2-3-10-26-22-27-12-17-18(14-4-9-19(23)20(24)11-14)13-29(21(17)28-22)16-7-5-15(25)6-8-16/h4,9,11-13,15-16H,2-3,5-8,10,25H2,1H3,(H,26,27,28)/t15-,16?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350870
PNG
(UNC2421A | US9795606, D1)
Show SMILES CCCCNc1ncc2n(cc(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-26-27(31-28)25(22-7-11-24(35)12-8-22)20-34(26)23-9-5-21(6-10-23)19-33-16-14-32(2)15-17-33/h5-6,9-10,18,20,22,24,35H,3-4,7-8,11-17,19H2,1-2H3,(H,29,30,31)/t22?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350843
PNG
(UNC1971A | US9795606, B2)
Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C26H35FN6O3S/c1-2-3-10-29-26-30-16-21-22(17-33(25(21)31-26)20-7-5-19(28)6-8-20)18-4-9-24(23(27)15-18)37(34,35)32-11-13-36-14-12-32/h4,9,15-17,19-20H,2-3,5-8,10-14,28H2,1H3,(H,29,30,31)/t19-,20?
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350860
PNG
(UNC2370A | US9795606, B19)
Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12
Show InChI InChI=1S/C28H37N5O2/c34-24-9-7-23(8-10-24)33-19-26(22-5-3-21(4-6-22)18-32-13-15-35-16-14-32)25-17-30-28(31-27(25)33)29-12-11-20-1-2-20/h3-6,17,19-20,23-24,34H,1-2,7-16,18H2,(H,29,30,31)/t23?,24-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM350869
PNG
(UNC2369A | US9795606, B30)
Show SMILES CCCCN(C)c1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1S/C29H42N6O/c1-4-5-14-33(3)29-30-19-26-27(21-35(28(26)31-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-17-15-32(2)16-18-34/h6-9,19,21,24-25,36H,4-5,10-18,20H2,1-3H3/t24-,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9795606 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%