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Patent code US9795611

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200576
PNG
(US9227975, 4 | US9795611, 4)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H22F2N6O3S/c1-36(34,35)30-17-7-4-15(5-8-17)24(33)28-23-14-27-21-10-11-22(29-32(21)23)31-12-2-3-20(31)18-13-16(25)6-9-19(18)26/h4-11,13-14,20,30H,2-3,12H2,1H3,(H,28,33)/t20-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200614
PNG
(US9227975, 40 | US9796723, 40)
Show SMILES O[C@@H]1CN(C[C@H]1O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O3/c22-12-3-4-14(23)13(8-12)15-2-1-7-28(15)19-6-5-18-24-9-20(29(18)26-19)25-21(32)27-10-16(30)17(31)11-27/h3-6,8-9,15-17,30-31H,1-2,7,10-11H2,(H,25,32)/t15-,16-,17-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200633
PNG
(US9227975, 57 | US9796723, 57)
Show SMILES Cn1nc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H19F2N7O2/c1-29-21(32)9-6-16(27-29)22(33)26-20-12-25-18-7-8-19(28-31(18)20)30-10-2-3-17(30)14-11-13(23)4-5-15(14)24/h4-9,11-12,17H,2-3,10H2,1H3,(H,26,33)/t17-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200582
PNG
(US9227975, 10 | US9795611, 10)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17+/m0/s1
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200575
PNG
(US9227975, 3 | US9795611, 3)
Show SMILES CC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N5O/c1-11(26)22-18-10-21-16-6-7-17(23-25(16)18)24-8-2-3-15(24)13-9-12(19)4-5-14(13)20/h4-7,9-10,15H,2-3,8H2,1H3,(H,22,26)/t15-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200604
PNG
(US9227975, 30 | US9796723, 30)
Show SMILES COc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-23-14-27-21-10-11-22(30-32(21)23)31-12-2-3-20(31)18-13-15(25)4-9-19(18)26/h4-11,13-14,20H,2-3,12H2,1H3,(H2,28,29,33)/t20-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200599
PNG
(US9227975, 26 | US9796723, 26)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCCCC3)n2n1
Show InChI InChI=1S/C22H24F2N6O/c23-15-6-7-17(24)16(13-15)18-5-4-12-29(18)20-9-8-19-25-14-21(30(19)27-20)26-22(31)28-10-2-1-3-11-28/h6-9,13-14,18H,1-5,10-12H2,(H,26,31)/t18-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200573
PNG
(US9227975, 1 | US9795611, 1)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccccc3)n2n1
Show InChI InChI=1S/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)19-7-4-12-30(19)21-11-10-20-26-14-22(31(20)29-21)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-11,13-14,19H,4,7,12H2,(H2,27,28,32)/t19-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200622
PNG
(US9227975, 48 | US9796723, 48)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C28H35F2N7O3/c1-27(2,3)40-26(39)36-14-13-34(17-28(36,4)5)25(38)32-24-16-31-22-10-11-23(33-37(22)24)35-12-6-7-21(35)19-15-18(29)8-9-20(19)30/h8-11,15-16,21H,6-7,12-14,17H2,1-5H3,(H,32,38)/t21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200629
PNG
(US9227975, 54 | US9796723, 54)
Show SMILES CC1(O)CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c1-21(31)11-27(12-21)20(30)25-19-10-24-17-6-7-18(26-29(17)19)28-8-2-3-16(28)14-9-13(22)4-5-15(14)23/h4-7,9-10,16,31H,2-3,8,11-12H2,1H3,(H,25,30)/t16-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.90n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200586
PNG
(US9227975, 13 | US9795611, 13)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H20F2N6O2/c21-12-3-4-15(22)14(8-12)16-2-1-7-27(16)18-6-5-17-23-9-19(28(17)25-18)24-20(30)26-10-13(29)11-26/h3-6,8-9,13,16,29H,1-2,7,10-11H2,(H,24,30)/t16-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200603
PNG
(US9227975, 29 | US9796723, 29)
Show SMILES CC(C)(C)NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N6O/c1-21(2,3)26-20(30)25-19-12-24-17-8-9-18(27-29(17)19)28-10-4-5-16(28)14-11-13(22)6-7-15(14)23/h6-9,11-12,16H,4-5,10H2,1-3H3,(H2,25,26,30)/t16-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200595
PNG
(US9227975, 22 | US9795611, 22)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-22-13-27-20-9-10-21(30-32(20)22)31-11-1-2-19(31)17-12-15(25)5-8-18(17)26/h3-10,12-13,19H,1-2,11H2,(H2,28,29,33)/t19-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200632
PNG
(US9227975, 56 | US9796723, 56)
Show SMILES Cn1cc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H20F2N6O2/c1-29-13-14(4-9-22(29)32)23(33)27-21-12-26-19-7-8-20(28-31(19)21)30-10-2-3-18(30)16-11-15(24)5-6-17(16)25/h4-9,11-13,18H,2-3,10H2,1H3,(H,27,33)/t18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200621
PNG
(US9227975, 47 | US9796723, 47)
Show SMILES CN(CCO)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H22F2N6O2/c1-26(9-10-29)20(30)24-19-12-23-17-6-7-18(25-28(17)19)27-8-2-3-16(27)14-11-13(21)4-5-15(14)22/h4-7,11-12,16,29H,2-3,8-10H2,1H3,(H,24,30)/t16-/m1/s1
PDB
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200580
PNG
(US9227975, 8 | US9795611, 8)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C24H19F5N6O/c25-15-6-7-18(26)17(12-15)19-5-2-10-34(19)21-9-8-20-30-13-22(35(20)33-21)32-23(36)31-16-4-1-3-14(11-16)24(27,28)29/h1,3-4,6-9,11-13,19H,2,5,10H2,(H2,31,32,36)/t19-/m1/s1
PDB
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UniProtKB/SwissProt

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200610
PNG
(US9227975, 36 | US9796723, 36)
Show SMILES C[C@@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-24-15-30-22-9-10-23(32-36(22)24)35-11-5-6-21(35)19-14-18(28)7-8-20(19)29/h7-10,14-15,17,21H,5-6,11-13,16H2,1-4H3,(H,31,37)/t17-,21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200598
PNG
(US9227975, 25 | US9796723, 25)
Show SMILES OC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H24F2N6O2/c23-14-3-4-17(24)16(12-14)18-2-1-9-29(18)20-6-5-19-25-13-21(30(19)27-20)26-22(32)28-10-7-15(31)8-11-28/h3-6,12-13,15,18,31H,1-2,7-11H2,(H,26,32)/t18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.8n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200590
PNG
(US9227975, 17 | US9795611, 17)
Show SMILES CC(C)(C)OC(=O)NC1CCCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-27(2,3)39-26(38)31-18-6-4-12-34(16-18)25(37)32-24-15-30-22-10-11-23(33-36(22)24)35-13-5-7-21(35)19-14-17(28)8-9-20(19)29/h8-11,14-15,18,21H,4-7,12-13,16H2,1-3H3,(H,31,38)(H,32,37)/t18?,21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.8n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200626
PNG
(US9227975, 52 | US9796723, 52)
Show SMILES OCC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(8-14)17-2-1-7-28(17)19-6-5-18-24-9-20(29(18)26-19)25-21(31)27-10-13(11-27)12-30/h3-6,8-9,13,17,30H,1-2,7,10-12H2,(H,25,31)/t17-/m1/s1
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UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200583
PNG
(US9227975, 11 | US9795611, 11)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17-/m1/s1
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n/an/a 15.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200628
PNG
(US9227975, 53 | US9796723, 53)
Show SMILES COC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c1-31-14-11-27(12-14)21(30)25-20-10-24-18-6-7-19(26-29(18)20)28-8-2-3-17(28)15-9-13(22)4-5-16(15)23/h4-7,9-10,14,17H,2-3,8,11-12H2,1H3,(H,25,30)/t17-/m1/s1
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n/an/a 16.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200635
PNG
(US9227975, 59 | US9796723, 59)
Show SMILES OC1(CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C23H23F5N6O2/c24-14-3-4-16(25)15(12-14)17-2-1-9-33(17)19-6-5-18-29-13-20(34(18)31-19)30-21(35)32-10-7-22(36,8-11-32)23(26,27)28/h3-6,12-13,17,36H,1-2,7-11H2,(H,30,35)/t17-/m1/s1
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n/an/a 16.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200585
PNG
(US9227975, 12 | US9795611, 12)
Show SMILES CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-27(2,3)39-26(38)31-18-10-13-34(14-11-18)25(37)32-24-16-30-22-8-9-23(33-36(22)24)35-12-4-5-21(35)19-15-17(28)6-7-20(19)29/h6-9,15-16,18,21H,4-5,10-14H2,1-3H3,(H,31,38)(H,32,37)/t21-/m1/s1
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n/an/a 17.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200620
PNG
(US9227975, 46 | US9796723, 46)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCC3)n2n1
Show InChI InChI=1S/C20H20F2N6O/c21-13-4-5-15(22)14(11-13)16-3-1-10-27(16)18-7-6-17-23-12-19(28(17)25-18)24-20(29)26-8-2-9-26/h4-7,11-12,16H,1-3,8-10H2,(H,24,29)/t16-/m1/s1
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n/an/a 17.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200589
PNG
(US9227975, 16 | US9795611, 16)
Show SMILES CN(C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O/c1-25(2)19(28)23-18-11-22-16-7-8-17(24-27(16)18)26-9-3-4-15(26)13-10-12(20)5-6-14(13)21/h5-8,10-11,15H,3-4,9H2,1-2H3,(H,23,28)/t15-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200631
PNG
(US9227975, 55 | US9795611, 55)
Show SMILES CC(C)C(=O)OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H26F2N6O3/c1-14(2)23(33)35-16-12-30(13-16)24(34)28-22-11-27-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-15(25)5-6-18(17)26/h5-8,10-11,14,16,19H,3-4,9,12-13H2,1-2H3,(H,28,34)/t19-/m1/s1
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n/an/a 19.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200605
PNG
(US9227975, 31 | US9796723, 31)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C25H28F2N6O3/c1-2-36-24(34)16-9-12-31(13-10-16)25(35)29-23-15-28-21-7-8-22(30-33(21)23)32-11-3-4-20(32)18-14-17(26)5-6-19(18)27/h5-8,14-16,20H,2-4,9-13H2,1H3,(H,29,35)/t20-/m1/s1
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n/an/a 20.1n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200636
PNG
(US9227975, 60 | US9796723, 60)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)C(F)(F)F)n2n1
Show InChI InChI=1S/C18H14F5N5O/c19-10-3-4-12(20)11(8-10)13-2-1-7-27(13)15-6-5-14-24-9-16(28(14)26-15)25-17(29)18(21,22)23/h3-6,8-9,13H,1-2,7H2,(H,25,29)/t13-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200618
PNG
(US9227975, 44 | US9796723, 44)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCC(F)(F)C3)n2n1
Show InChI InChI=1S/C21H20F4N6O/c22-13-3-4-15(23)14(10-13)16-2-1-8-30(16)18-6-5-17-26-11-19(31(17)28-18)27-20(32)29-9-7-21(24,25)12-29/h3-6,10-11,16H,1-2,7-9,12H2,(H,27,32)/t16-/m1/s1
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n/an/a 22.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200587
PNG
(US9227975, 14 | US9795611, 14)
Show SMILES CC(C)(C)OC(=O)NC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C25H29F2N7O3/c1-25(2,3)37-24(36)29-16-13-32(14-16)23(35)30-22-12-28-20-8-9-21(31-34(20)22)33-10-4-5-19(33)17-11-15(26)6-7-18(17)27/h6-9,11-12,16,19H,4-5,10,13-14H2,1-3H3,(H,29,36)(H,30,35)/t19-/m1/s1
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n/an/a 23.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200574
PNG
(US9227975, 2 | US9795611, 2)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCOCC3)n2n1
Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(12-14)17-2-1-7-28(17)19-6-5-18-24-13-20(29(18)26-19)25-21(30)27-8-10-31-11-9-27/h3-6,12-13,17H,1-2,7-11H2,(H,25,30)/t17-/m1/s1
PDB
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n/an/a 23.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200616
PNG
(US9227975, 42 | US9796723, 42)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCNC(=O)C3)n2n1
Show InChI InChI=1S/C21H21F2N7O2/c22-13-3-4-15(23)14(10-13)16-2-1-8-29(16)18-6-5-17-25-11-19(30(17)27-18)26-21(32)28-9-7-24-20(31)12-28/h3-6,10-11,16H,1-2,7-9,12H2,(H,24,31)(H,26,32)/t16-/m1/s1
PDB
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n/an/a 26.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200625
PNG
(US9227975, 51 | US9796723, 51)
Show SMILES CC(C)[C@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H29F2N7O/c1-15(2)19-14-31(11-9-27-19)24(34)29-23-13-28-21-7-8-22(30-33(21)23)32-10-3-4-20(32)17-12-16(25)5-6-18(17)26/h5-8,12-13,15,19-20,27H,3-4,9-11,14H2,1-2H3,(H,29,34)/t19-,20-/m1/s1
PDB
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n/an/a 27.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200613
PNG
(US9227975, 39 | US9795611, 39)
Show SMILES C[C@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-14-13-29(10-8-25-14)22(32)27-21-12-26-19-6-7-20(28-31(19)21)30-9-2-3-18(30)16-11-15(23)4-5-17(16)24/h4-7,11-12,14,18,25H,2-3,8-10,13H2,1H3,(H,27,32)/t14-,18+/m0/s1
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n/an/a 29.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200588
PNG
(US9227975, 15 | US9795611, 15)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C26H31F2N7O3/c1-26(2,3)38-25(37)33-13-11-32(12-14-33)24(36)30-23-16-29-21-8-9-22(31-35(21)23)34-10-4-5-20(34)18-15-17(27)6-7-19(18)28/h6-9,15-16,20H,4-5,10-14H2,1-3H3,(H,30,36)/t20-/m1/s1
PDB
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n/an/a 33.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200579
PNG
(US9227975, 7 | US9795611, 7)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccc(Cl)cc3Cl)n2n1
Show InChI InChI=1S/C23H18Cl2F2N6O/c24-13-3-6-18(16(25)10-13)29-23(34)30-22-12-28-20-7-8-21(31-33(20)22)32-9-1-2-19(32)15-11-14(26)4-5-17(15)27/h3-8,10-12,19H,1-2,9H2,(H2,29,30,34)/t19-/m1/s1
PDB
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n/an/a 39.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200611
PNG
(US9227975, 37 | US9796723, 37)
Show SMILES C[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C27H33F2N7O3/c1-17-16-33(12-13-34(17)26(38)39-27(2,3)4)25(37)31-24-15-30-22-9-10-23(32-36(22)24)35-11-5-6-21(35)19-14-18(28)7-8-20(19)29/h7-10,14-15,17,21H,5-6,11-13,16H2,1-4H3,(H,31,37)/t17-,21+/m0/s1
PDB
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n/an/a 40.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200594
PNG
(US9227975, 21 | US9795611, 21)
Show SMILES NC1CCCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c23-14-5-6-17(24)16(11-14)18-4-2-10-30(18)20-8-7-19-26-12-21(31(19)28-20)27-22(32)29-9-1-3-15(25)13-29/h5-8,11-12,15,18H,1-4,9-10,13,25H2,(H,27,32)/t15?,18-/m1/s1
PDB
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UniChem
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n/an/a 42n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200612
PNG
(US9227975, 38 | US9796723, 38)
Show SMILES C[C@@H]1CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-14-13-29(10-8-25-14)22(32)27-21-12-26-19-6-7-20(28-31(19)21)30-9-2-3-18(30)16-11-15(23)4-5-17(16)24/h4-7,11-12,14,18,25H,2-3,8-10,13H2,1H3,(H,27,32)/t14-,18-/m1/s1
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n/an/a 47.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US9227975, 35 | US9796723, 35)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/m1/s1
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n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200591
PNG
(US9227975, 18 | US9795611, 18)
Show SMILES NC1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c23-14-3-4-17(24)16(12-14)18-2-1-9-30(18)20-6-5-19-26-13-21(31(19)28-20)27-22(32)29-10-7-15(25)8-11-29/h3-6,12-13,15,18H,1-2,7-11,25H2,(H,27,32)/t18-/m1/s1
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n/an/a 52.9n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200634
PNG
(US9227975, 58 | US9796723, 58)
Show SMILES CN1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N7O/c1-28-9-11-29(12-10-28)22(32)26-21-14-25-19-6-7-20(27-31(19)21)30-8-2-3-18(30)16-13-15(23)4-5-17(16)24/h4-7,13-14,18H,2-3,8-12H2,1H3,(H,26,32)/t18-/m1/s1
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n/an/a 53.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200624
PNG
(US9227975, 50 | US9796723, 50)
Show SMILES CC1(C)CN(CCN1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H27F2N7O/c1-23(2)14-30(11-9-27-23)22(33)28-21-13-26-19-7-8-20(29-32(19)21)31-10-3-4-18(31)16-12-15(24)5-6-17(16)25/h5-8,12-13,18,27H,3-4,9-11,14H2,1-2H3,(H,28,33)/t18-/m1/s1
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n/an/a 60.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200608
PNG
(US9227975, 34 | US9796723, 34)
Show SMILES OC(=O)C1CCN(CC1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H24F2N6O3/c24-15-3-4-17(25)16(12-15)18-2-1-9-30(18)20-6-5-19-26-13-21(31(19)28-20)27-23(34)29-10-7-14(8-11-29)22(32)33/h3-6,12-14,18H,1-2,7-11H2,(H,27,34)(H,32,33)/t18-/m1/s1
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n/an/a 64.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200602
PNG
(US9227975, 28 | US9796723, 28)
Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1
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n/an/a 65.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200577
PNG
(US9227975, 5 | US9795611, 5)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C#N)n2n1
Show InChI InChI=1S/C24H19F2N7O/c25-16-6-7-19(26)18(12-16)20-5-2-10-32(20)22-9-8-21-28-14-23(33(21)31-22)30-24(34)29-17-4-1-3-15(11-17)13-27/h1,3-4,6-9,11-12,14,20H,2,5,10H2,(H2,29,30,34)/t20-/m1/s1
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n/an/a 74.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200596
PNG
(US9227975, 23 | US9796723, 23)
Show SMILES CC(C)(C)OC(=O)N1C2CCC1CN(C2)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C28H33F2N7O3/c1-28(2,3)40-27(39)36-18-7-8-19(36)16-34(15-18)26(38)32-25-14-31-23-10-11-24(33-37(23)25)35-12-4-5-22(35)20-13-17(29)6-9-21(20)30/h6,9-11,13-14,18-19,22H,4-5,7-8,12,15-16H2,1-3H3,(H,32,38)/t18?,19?,22-/m1/s1
PDB
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n/an/a 75.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200601
PNG
(US9227975, 27 | US9796723, 27)
Show SMILES NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C17H16F2N6O/c18-10-3-4-12(19)11(8-10)13-2-1-7-24(13)15-6-5-14-21-9-16(22-17(20)26)25(14)23-15/h3-6,8-9,13H,1-2,7H2,(H3,20,22,26)/t13-/m1/s1
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n/an/a 77.1n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200619
PNG
(US9227975, 45 | US9796723, 45)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CC(F)(F)C3)n2n1
Show InChI InChI=1S/C20H18F4N6O/c21-12-3-4-14(22)13(8-12)15-2-1-7-29(15)17-6-5-16-25-9-18(30(16)27-17)26-19(31)28-10-20(23,24)11-28/h3-6,8-9,15H,1-2,7,10-11H2,(H,26,31)/t15-/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200593
PNG
(US9227975, 20 | US9795611, 20)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCNCC3)n2n1
Show InChI InChI=1S/C21H23F2N7O/c22-14-3-4-16(23)15(12-14)17-2-1-9-29(17)19-6-5-18-25-13-20(30(18)27-19)26-21(31)28-10-7-24-8-11-28/h3-6,12-13,17,24H,1-2,7-11H2,(H,26,31)/t17-/m1/s1
PDB
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n/an/a 94.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200597
PNG
(US9227975, 24 | US9796723, 24)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CC4CCC(C3)N4)n2n1
Show InChI InChI=1S/C23H25F2N7O/c24-14-3-6-18(25)17(10-14)19-2-1-9-31(19)21-8-7-20-26-11-22(32(20)29-21)28-23(33)30-12-15-4-5-16(13-30)27-15/h3,6-8,10-11,15-16,19,27H,1-2,4-5,9,12-13H2,(H,28,33)/t15?,16?,19-/m1/s1
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n/an/a 107n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200592
PNG
(US9227975, 19 | US9795611, 19)
Show SMILES NC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N7O/c21-12-3-4-15(22)14(8-12)16-2-1-7-28(16)18-6-5-17-24-9-19(29(17)26-18)25-20(30)27-10-13(23)11-27/h3-6,8-9,13,16H,1-2,7,10-11,23H2,(H,25,30)/t16-/m1/s1
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n/an/a 126n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200606
PNG
(US9227975, 32 | US9796723, 32)
Show SMILES COc1cc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc(OC)c1OC
Show InChI InChI=1S/C26H26F2N6O4/c1-36-20-12-16(13-21(37-2)25(20)38-3)30-26(35)31-24-14-29-22-8-9-23(32-34(22)24)33-10-4-5-19(33)17-11-15(27)6-7-18(17)28/h6-9,11-14,19H,4-5,10H2,1-3H3,(H2,30,31,35)/t19-/m1/s1
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n/an/a 176n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200617
PNG
(US9227975, 43 | US9796723, 43)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCCCC1c1cccc(F)c1
Show InChI InChI=1S/C21H23FN6O2/c22-15-5-3-4-14(10-15)17-6-1-2-9-27(17)19-8-7-18-23-11-20(28(18)25-19)24-21(30)26-12-16(29)13-26/h3-5,7-8,10-11,16-17,29H,1-2,6,9,12-13H2,(H,24,30)
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n/an/a 216n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200580
PNG
(US9227975, 8 | US9795611, 8)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C24H19F5N6O/c25-15-6-7-18(26)17(12-15)19-5-2-10-34(19)21-9-8-20-30-13-22(35(20)33-21)32-23(36)31-16-4-1-3-14(11-16)24(27,28)29/h1,3-4,6-9,11-13,19H,2,5,10H2,(H2,31,32,36)/t19-/m1/s1
PDB
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n/an/a 508n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200581
PNG
(US9227975, 9 | US9795611, 9)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3cc(Cl)cc(Cl)c3)n2n1
Show InChI InChI=1S/C23H18Cl2F2N6O/c24-13-8-14(25)10-16(9-13)29-23(34)30-22-12-28-20-5-6-21(31-33(20)22)32-7-1-2-19(32)17-11-15(26)3-4-18(17)27/h3-6,8-12,19H,1-2,7H2,(H2,29,30,34)/t19-/m1/s1
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n/an/a 717n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200623
PNG
(US9227975, 49 | US9796723, 49)
Show SMILES CC(C)[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C29H37F2N7O3/c1-18(2)23-17-35(13-14-37(23)28(40)41-29(3,4)5)27(39)33-26-16-32-24-10-11-25(34-38(24)26)36-12-6-7-22(36)20-15-19(30)8-9-21(20)31/h8-11,15-16,18,22-23H,6-7,12-14,17H2,1-5H3,(H,33,39)/t22-,23-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 857n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM350926
PNG
((R)-1-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)im...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)NN3CCS(=O)(=O)CC3)n2n1
Show InChI InChI=1S/C21H23F2N7O3S/c22-14-3-4-16(23)15(12-14)17-2-1-7-29(17)19-6-5-18-24-13-20(30(18)26-19)25-21(31)27-28-8-10-34(32,33)11-9-28/h3-6,12-13,17H,1-2,7-11H2,(H2,25,27,31)/t17-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 884n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200607
PNG
(US9227975, 33 | US9796723, 33)
Show SMILES Cc1noc(C)c1NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H21F2N7O2/c1-12-21(13(2)33-29-12)27-22(32)26-20-11-25-18-7-8-19(28-31(18)20)30-9-3-4-17(30)15-10-14(23)5-6-16(15)24/h5-8,10-11,17H,3-4,9H2,1-2H3,(H2,26,27,32)/t17-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 901n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%