BindingDB logo
myBDB logout

Patent code US9796672

Compile Data Set for Download or QSAR
Found 170 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349368
PNG
(US10207991, Ex. Cpd. No. 11)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.440n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349518
PNG
(US10207991, Ex. Cpd. No. 34)
Show SMILES COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
Show InChI InChI=1S/C21H26FNO2/c1-21(2,10-9-15-5-7-18(22)8-6-15)23-13-16-11-19(24-3)20(25-4)12-17(16)14-23/h5-8,11-12H,9-10,13-14H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.530n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349505
PNG
(US10207991, Ex. Cpd. No. 20)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.570n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349505
PNG
(US10207991, Ex. Cpd. No. 20)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.670n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349569
PNG
(US10207991, Ex. Cpd. No. 87)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-17(2)16-29-23-12-18(6-9-22(23)26)10-11-24(3,4)25-14-19-7-8-21(30(5,27)28)13-20(19)15-25/h6-9,12-13,17,26H,10-11,14-16H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349570
PNG
(US10207991, Ex. Cpd. No. 88)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C23H30FNO2/c1-16(2)15-27-22-12-17(8-9-21(22)26)10-11-23(3,4)25-13-18-6-5-7-20(24)19(18)14-25/h5-9,12,16,26H,10-11,13-15H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.30n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349578
PNG
(US10207991, Ex. Cpd. No. 103)
Show SMILES COc1cccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)c1
Show InChI InChI=1S/C21H27NO3S/c1-21(2,11-10-16-6-5-7-19(12-16)25-3)22-14-17-8-9-20(26(4,23)24)13-18(17)15-22/h5-9,12-13H,10-11,14-15H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349365
PNG
(US10207991, Ex. Cpd. No. 10)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C19H19Cl2NO2/c1-12(2-3-13-4-5-16(20)17(21)6-13)22-9-14-7-18-19(24-11-23-18)8-15(14)10-22/h4-8,12H,2-3,9-11H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349387
PNG
(US10207991, Ex. Cpd. No. 18)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3ccccc3cc2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-9-21(23)22(24)10-16)25-13-19-11-17-4-2-3-5-18(17)12-20(19)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349577
PNG
(US10207991, Ex. Cpd. No. 102)
Show SMILES COc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C21H27NO3S/c1-21(2,12-11-16-5-8-19(25-3)9-6-16)22-14-17-7-10-20(26(4,23)24)13-18(17)15-22/h5-10,13H,11-12,14-15H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM350897
PNG
(US9796672, Example Compound 19)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc3ccccc3c2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-11-21(23)22(24)12-16)25-13-18-10-9-17-4-2-3-5-19(17)20(18)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349519
PNG
(US10207991, Ex. Cpd. No. 35)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,10-9-14-3-6-17(20)7-4-14)22-12-15-5-8-18(21)11-16(15)13-22/h3-8,11H,9-10,12-13H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349307
PNG
(US10207991, Ex. Cpd. No. 4)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F
Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349551
PNG
(US10207991, Ex. Cpd. No. 66)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-21-14-17(10-11-20(21)26)12-13-24(4,5)25-15-18-8-7-9-22(19(18)16-25)30(6,27)28/h7-11,14,26H,12-13,15-16H2,1-6H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349559
PNG
(US10207991, Ex. Cpd. No. 76)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)ccc1O
Show InChI InChI=1S/C25H33N3O3/c1-25(2,10-9-18-7-8-22(29)23(15-18)31-3)28-16-19-5-4-6-20(21(19)17-28)24(30)27-13-11-26-12-14-27/h4-8,15,26,29H,9-14,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349316
PNG
(US10207991, Ex. Cpd. No. 5)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc(Cl)c(Cl)cc2C1
Show InChI InChI=1S/C18H17Cl4N/c1-11(2-3-12-4-5-15(19)16(20)6-12)23-9-13-7-17(21)18(22)8-14(13)10-23/h4-8,11H,2-3,9-10H2,1H3/t11-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.70n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349517
PNG
(US10207991, Ex. Cpd. No. 33)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,11-10-14-6-8-16(20)9-7-14)22-12-15-4-3-5-18(21)17(15)13-22/h3-9H,10-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349519
PNG
(US10207991, Ex. Cpd. No. 35)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,10-9-14-3-6-17(20)7-4-14)22-12-15-5-8-18(21)11-16(15)13-22/h3-8,11H,9-10,12-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349325
PNG
(US10207991, Ex. Cpd. No. 9)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C18H18Cl2FN/c1-12(5-6-13-7-8-16(19)17(20)9-13)22-10-14-3-2-4-18(21)15(14)11-22/h2-4,7-9,12H,5-6,10-11H2,1H3/t12-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349516
PNG
(US10207991, Ex. Cpd. No. 31)
Show SMILES C[C@H](CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H19F4NO2/c1-12(24-10-14-5-6-16(20)9-15(14)11-24)2-3-13-4-7-17(25)18(8-13)26-19(21,22)23/h4-9,12,25H,2-3,10-11H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.70n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349520
PNG
(US10207991, Ex. Cpd. No. 36)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C20H22FNO2/c1-20(2,8-7-14-3-5-17(21)6-4-14)22-11-15-9-18-19(24-13-23-18)10-16(15)12-22/h3-6,9-10H,7-8,11-13H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
4.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349509
PNG
(US10207991, Ex. Cpd. No. 24)
Show SMILES C[C@H](CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C20H20F3NO4/c1-12(2-3-13-4-5-16(25)17(6-13)28-20(21,22)23)24-9-14-7-18-19(27-11-26-18)8-15(14)10-24/h4-8,12,25H,2-3,9-11H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
4.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349365
PNG
(US10207991, Ex. Cpd. No. 10)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C19H19Cl2NO2/c1-12(2-3-13-4-5-16(20)17(21)6-13)22-9-14-7-18-19(24-11-23-18)8-15(14)10-22/h4-8,12H,2-3,9-11H2,1H3/t12-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349520
PNG
(US10207991, Ex. Cpd. No. 36)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C20H22FNO2/c1-20(2,8-7-14-3-5-17(21)6-4-14)22-11-15-9-18-19(24-13-23-18)10-16(15)12-22/h3-6,9-10H,7-8,11-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349510
PNG
(US10207991, Ex. Cpd. No. 25)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)ccc1O
Show InChI InChI=1S/C22H27NO4/c1-14(2)27-20-8-16(6-7-19(20)24)5-4-15(3)23-11-17-9-21-22(26-13-25-21)10-18(17)12-23/h6-10,14-15,24H,4-5,11-13H2,1-3H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.70n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349526
PNG
(US10207991, Ex. Cpd. No. 42)
Show SMILES CC(C)Oc1ccc(CCC(C)(C)N2Cc3ccc(F)cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H34FNO2/c1-17(2)28-23-10-7-19(13-24(23)29-18(3)4)11-12-25(5,6)27-15-20-8-9-22(26)14-21(20)16-27/h7-10,13-14,17-18H,11-12,15-16H2,1-6H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
6.20n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349572
PNG
(US10207991, Ex. Cpd. No. 96)
Show SMILES CC(=O)Oc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1OC(C)(C)C
Show InChI InChI=1S/C26H35NO5S/c1-18(28)31-23-11-8-19(14-24(23)32-25(2,3)4)12-13-26(5,6)27-16-20-9-10-22(33(7,29)30)15-21(20)17-27/h8-11,14-15H,12-13,16-17H2,1-7H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
6.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349546
PNG
(US10207991, Ex. Cpd. No. 61)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,9-8-14-4-7-18(26)19(10-14)29-21(22,23)24)25-12-15-5-6-17(30(3,27)28)11-16(15)13-25/h4-7,10-11,26H,8-9,12-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
6.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349518
PNG
(US10207991, Ex. Cpd. No. 34)
Show SMILES COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
Show InChI InChI=1S/C21H26FNO2/c1-21(2,10-9-15-5-7-18(22)8-6-15)23-13-16-11-19(24-3)20(25-4)12-17(16)14-23/h5-8,11-12H,9-10,13-14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
7.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349524
PNG
(US10207991, Ex. Cpd. No. 40)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H33NO4/c1-16(2)29-22-9-8-19(10-25(22)30-17(3)4)7-6-18(5)26-13-20-11-23-24(28-15-27-23)12-21(20)14-26/h8-12,16-18H,6-7,13-15H2,1-5H3/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
7.80n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349511
PNG
(US10207991, Ex. Cpd. No. 26)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C21H26FNO2/c1-14(2)25-21-11-16(9-10-20(21)24)8-7-15(3)23-12-17-5-4-6-19(22)18(17)13-23/h4-6,9-11,14-15,24H,7-8,12-13H2,1-3H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
7.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349552
PNG
(US10207991, Ex. Cpd. No. 67)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(c2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,10-9-14-7-8-17(26)18(11-14)29-21(22,23)24)25-12-15-5-4-6-19(16(15)13-25)30(3,27)28/h4-8,11,26H,9-10,12-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
8.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349547
PNG
(US10207991, Ex. Cpd. No. 62)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-14,26H,11-12,15-16H2,1-6H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
8.5n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349549
PNG
(US10207991, Ex. Cpd. No. 64)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C21H27NO4S/c1-21(2,11-10-15-8-9-18(23)19(12-15)26-3)22-13-16-6-5-7-20(17(16)14-22)27(4,24)25/h5-9,12,23H,10-11,13-14H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
8.60n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349524
PNG
(US10207991, Ex. Cpd. No. 40)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H33NO4/c1-16(2)29-22-9-8-19(10-25(22)30-17(3)4)7-6-18(5)26-13-20-11-23-24(28-15-27-23)12-21(20)14-26/h8-12,16-18H,6-7,13-15H2,1-5H3/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
8.90n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349555
PNG
(US10207991, Ex. Cpd. No. 70)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C23H31NO4S/c1-16(2)28-22-12-17(6-9-21(22)25)10-11-23(3,4)24-14-18-7-8-20(29(5,26)27)13-19(18)15-24/h6-9,12-13,16,25H,10-11,14-15H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
9n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349521
PNG
(US10207991, Ex. Cpd. No. 37)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)ccc1O
Show InChI InChI=1S/C21H26FNO2/c1-14(2)25-21-10-16(6-9-20(21)24)5-4-15(3)23-12-17-7-8-19(22)11-18(17)13-23/h6-11,14-15,24H,4-5,12-13H2,1-3H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
9.10n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349513
PNG
(US10207991, Ex. Cpd. No. 28)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C22H28FNO2/c1-15(2)26-21-12-16(8-9-20(21)25)10-11-22(3,4)24-13-17-6-5-7-19(23)18(17)14-24/h5-9,12,15,25H,10-11,13-14H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
11n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349576
PNG
(US10207991, Ex. Cpd. No. 101)
Show SMILES COc1ccc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)cc1OC
Show InChI InChI=1S/C22H29NO4S/c1-22(2,11-10-16-6-9-20(26-3)21(12-16)27-4)23-14-17-7-8-19(28(5,24)25)13-18(17)15-23/h6-9,12-13H,10-11,14-15H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
11n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349506
PNG
(US10207991, Ex. Cpd. No. 21)
Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
12n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349508
PNG
(US10207991, Ex. Cpd. No. 23)
Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
13n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349514
PNG
(US10207991, Ex. Cpd. No. 29)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3cc4OCOc4cc3C2)ccc1O
Show InChI InChI=1S/C23H29NO4/c1-15(2)28-20-9-16(5-6-19(20)25)7-8-23(3,4)24-12-17-10-21-22(27-14-26-21)11-18(17)13-24/h5-6,9-11,15,25H,7-8,12-14H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
13n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349368
PNG
(US10207991, Ex. Cpd. No. 11)
Show SMILES COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
14n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349583
PNG
(US10207991, Ex. Cpd. No. 108)
Show SMILES CC(C)(CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)N1CCNCC1
Show InChI InChI=1S/C23H29Cl2N3/c1-23(2,8-7-17-3-6-21(24)22(25)13-17)28-15-18-4-5-20(14-19(18)16-28)27-11-9-26-10-12-27/h3-6,13-14,26H,7-12,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
15n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349508
PNG
(US10207991, Ex. Cpd. No. 23)
Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
16n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349548
PNG
(US10207991, Ex. Cpd. No. 63)
Show SMILES C[C@H](CCc1ccc(O)c(OC(C)(C)C)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C23H31NO4S/c1-16(6-7-17-8-11-21(25)22(12-17)28-23(2,3)4)24-14-18-9-10-20(29(5,26)27)13-19(18)15-24/h8-13,16,25H,6-7,14-15H2,1-5H3/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
17n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349325
PNG
(US10207991, Ex. Cpd. No. 9)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C18H18Cl2FN/c1-12(5-6-13-7-8-16(19)17(20)9-13)22-10-14-3-2-4-18(21)15(14)11-22/h2-4,7-9,12H,5-6,10-11H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
17n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349537
PNG
(US10207991, Ex. Cpd. No. 53)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C20H24FNO2/c1-20(2,10-9-14-7-8-18(23)19(11-14)24-3)22-12-15-5-4-6-17(21)16(15)13-22/h4-8,11,23H,9-10,12-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
17n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349538
PNG
(US10207991, Ex. Cpd. No. 54)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C20H21F4NO2/c1-19(2,25-11-14-4-3-5-16(21)15(14)12-25)9-8-13-6-7-17(26)18(10-13)27-20(22,23)24/h3-7,10,26H,8-9,11-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
18n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349522
PNG
(US10207991, Ex. Cpd. No. 38)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)cc1OC(C)C
Show InChI InChI=1S/C24H32FNO2/c1-16(2)27-23-11-8-19(12-24(23)28-17(3)4)7-6-18(5)26-14-20-9-10-22(25)13-21(20)15-26/h8-13,16-18H,6-7,14-15H2,1-5H3/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
18n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349523
PNG
(US10207991, Ex. Cpd. No. 39)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3cccc(F)c3C2)cc1OC(C)C
Show InChI InChI=1S/C24H32FNO2/c1-16(2)27-23-12-11-19(13-24(23)28-17(3)4)10-9-18(5)26-14-20-7-6-8-22(25)21(20)15-26/h6-8,11-13,16-18H,9-10,14-15H2,1-5H3/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
21n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349522
PNG
(US10207991, Ex. Cpd. No. 38)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)cc1OC(C)C
Show InChI InChI=1S/C24H32FNO2/c1-16(2)27-23-11-8-19(12-24(23)28-17(3)4)7-6-18(5)26-14-20-9-10-22(25)13-21(20)15-26/h8-13,16-18H,6-7,14-15H2,1-5H3/t18-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
21n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349556
PNG
(US10207991, Ex. Cpd. No. 73)
Show SMILES C[C@H](CCc1ccc(OCCO)c(OC(F)(F)F)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C21H23F4NO3/c1-14(26-12-16-5-6-18(22)11-17(16)13-26)2-3-15-4-7-19(28-9-8-27)20(10-15)29-21(23,24)25/h4-7,10-11,14,27H,2-3,8-9,12-13H2,1H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
22n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349532
PNG
(US10207991, Ex. Cpd. No. 48)
Show SMILES COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(OCCO)c(OC)c1
Show InChI InChI=1S/C24H33NO5/c1-24(2,9-8-17-6-7-20(30-11-10-26)21(12-17)27-3)25-15-18-13-22(28-4)23(29-5)14-19(18)16-25/h6-7,12-14,26H,8-11,15-16H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
22n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349507
PNG
(US10207991, Ex. Cpd. No. 22)
Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C18H19F2N/c1-13(2-3-14-4-7-17(19)8-5-14)21-11-15-6-9-18(20)10-16(15)12-21/h4-10,13H,2-3,11-12H2,1H3/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
23n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349268
PNG
(US10207991, Ex. Cpd. No. 3)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cc(Cl)c(Cl)cc3C2)ccc1O
Show InChI InChI=1S/C19H21Cl2NO2/c1-12(3-4-13-5-6-18(23)19(7-13)24-2)22-10-14-8-16(20)17(21)9-15(14)11-22/h5-9,12,23H,3-4,10-11H2,1-2H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
23n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349250
PNG
(US10207991, Ex. Cpd. No. 1)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3ccc(Cl)cc3C2)ccc1O
Show InChI InChI=1S/C19H22ClNO2/c1-13(3-4-14-5-8-18(22)19(9-14)23-2)21-11-15-6-7-17(20)10-16(15)12-21/h5-10,13,22H,3-4,11-12H2,1-2H3/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
25n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349533
PNG
(US10207991, Ex. Cpd. No. 49)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1OC(=O)N(C)C
Show InChI InChI=1S/C23H29FN2O3/c1-23(2,26-14-17-7-6-8-19(24)18(17)15-26)12-11-16-9-10-20(21(13-16)28-5)29-22(27)25(3)4/h6-10,13H,11-12,14-15H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
25n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349554
PNG
(US10207991, Ex. Cpd. No. 69)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C22H29NO4S/c1-15(2)27-22-11-17(7-10-21(22)24)6-5-16(3)23-13-18-8-9-20(28(4,25)26)12-19(18)14-23/h7-12,15-16,24H,5-6,13-14H2,1-4H3/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
27n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349250
PNG
(US10207991, Ex. Cpd. No. 1)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3ccc(Cl)cc3C2)ccc1O
Show InChI InChI=1S/C19H22ClNO2/c1-13(3-4-14-5-8-18(22)19(9-14)23-2)21-11-15-6-7-17(20)10-16(15)12-21/h5-10,13,22H,3-4,11-12H2,1-2H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
31n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349584
PNG
(US10207991, Ex. Cpd. No. 109)
Show SMILES CC(C)(CCc1ccc(Cl)c(Cl)c1)N1Cc2cccc(N3CCNCC3)c2C1
Show InChI InChI=1S/C23H29Cl2N3/c1-23(2,9-8-17-6-7-20(24)21(25)14-17)28-15-18-4-3-5-22(19(18)16-28)27-12-10-26-11-13-27/h3-7,14,26H,8-13,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
31n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349517
PNG
(US10207991, Ex. Cpd. No. 33)
Show SMILES CC(C)(CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C19H21F2N/c1-19(2,11-10-14-6-8-16(20)9-7-14)22-12-15-4-3-5-18(21)17(15)13-22/h3-9H,10-13H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
32n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349542
PNG
(US10207991, Ex. Cpd. No. 58)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C23H30FNO2/c1-22(2,3)27-21-13-16(9-10-20(21)26)11-12-23(4,5)25-14-17-7-6-8-19(24)18(17)15-25/h6-10,13,26H,11-12,14-15H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
32n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349307
PNG
(US10207991, Ex. Cpd. No. 4)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F
Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
33n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349546
PNG
(US10207991, Ex. Cpd. No. 61)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,9-8-14-4-7-18(26)19(10-14)29-21(22,23)24)25-12-15-5-6-17(30(3,27)28)11-16(15)13-25/h4-7,10-11,26H,8-9,12-13H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
33n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349545
PNG
(US10207991, Ex. Cpd. No. 60B)
Show SMILES C[C@H](CCc1ccc(O)c(OC(C)(C)C)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C22H28FNO2/c1-15(24-13-17-6-5-7-19(23)18(17)14-24)8-9-16-10-11-20(25)21(12-16)26-22(2,3)4/h5-7,10-12,15,25H,8-9,13-14H2,1-4H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
37n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349534
PNG
(US10207991, Ex. Cpd. No. 50)
Show SMILES COc1cc(CCC(C)(C)N2Cc3ccc(F)cc3C2)ccc1OC(=O)N(C)C
Show InChI InChI=1S/C23H29FN2O3/c1-23(2,26-14-17-7-8-19(24)13-18(17)15-26)11-10-16-6-9-20(21(12-16)28-5)29-22(27)25(3)4/h6-9,12-13H,10-11,14-15H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
37n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349525
PNG
(US10207991, Ex. Cpd. No. 41)
Show SMILES C[C@H](CCc1ccc(OC(=O)N(C)C)c(OC(F)(F)F)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C22H24F4N2O3/c1-14(28-12-16-5-4-6-18(23)17(16)13-28)7-8-15-9-10-19(30-21(29)27(2)3)20(11-15)31-22(24,25)26/h4-6,9-11,14H,7-8,12-13H2,1-3H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
38n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349324
PNG
(US10207991, Ex. Cpd. No. 8)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C19H22FNO2/c1-13(6-7-14-8-9-18(22)19(10-14)23-2)21-11-15-4-3-5-17(20)16(15)12-21/h3-5,8-10,13,22H,6-7,11-12H2,1-2H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
41n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349511
PNG
(US10207991, Ex. Cpd. No. 26)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C21H26FNO2/c1-14(2)25-21-11-16(9-10-20(21)24)8-7-15(3)23-12-17-5-4-6-19(22)18(17)13-23/h4-6,9-11,14-15,24H,7-8,12-13H2,1-3H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
41n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349323
PNG
(US10207991, Ex. Cpd. No. 7)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cc(OC)c(OC)cc3C2)ccc1O
Show InChI InChI=1S/C21H27NO4/c1-14(5-6-15-7-8-18(23)19(9-15)24-2)22-12-16-10-20(25-3)21(26-4)11-17(16)13-22/h7-11,14,23H,5-6,12-13H2,1-4H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
42n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349387
PNG
(US10207991, Ex. Cpd. No. 18)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc3ccccc3cc2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-9-21(23)22(24)10-16)25-13-19-11-17-4-2-3-5-18(17)12-20(19)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
42n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349507
PNG
(US10207991, Ex. Cpd. No. 22)
Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C18H19F2N/c1-13(2-3-14-4-7-17(19)8-5-14)21-11-15-6-9-18(20)10-16(15)12-21/h4-10,13H,2-3,11-12H2,1H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
44n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349512
PNG
(US10207991, Ex. Cpd. No. 27)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3ccc(F)cc3C2)ccc1O
Show InChI InChI=1S/C22H28FNO2/c1-15(2)26-21-11-16(5-8-20(21)25)9-10-22(3,4)24-13-17-6-7-19(23)12-18(17)14-24/h5-8,11-12,15,25H,9-10,13-14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
46n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349514
PNG
(US10207991, Ex. Cpd. No. 29)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3cc4OCOc4cc3C2)ccc1O
Show InChI InChI=1S/C23H29NO4/c1-15(2)28-20-9-16(5-6-19(20)25)7-8-23(3,4)24-12-17-10-21-22(27-14-26-21)11-18(17)13-24/h5-6,9-11,15,25H,7-8,12-14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
47n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349555
PNG
(US10207991, Ex. Cpd. No. 70)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C23H31NO4S/c1-16(2)28-22-12-17(6-9-21(22)25)10-11-23(3,4)24-14-18-7-8-20(29(5,26)27)13-19(18)15-24/h6-9,12-13,16,25H,10-11,14-15H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
50n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349509
PNG
(US10207991, Ex. Cpd. No. 24)
Show SMILES C[C@H](CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cc3OCOc3cc2C1
Show InChI InChI=1S/C20H20F3NO4/c1-12(2-3-13-4-5-16(25)17(6-13)28-20(21,22)23)24-9-14-7-18-19(27-11-26-18)8-15(14)10-24/h4-8,12,25H,2-3,9-11H2,1H3/t12-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
52n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349552
PNG
(US10207991, Ex. Cpd. No. 67)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(c2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H24F3NO4S/c1-20(2,10-9-14-7-8-17(26)18(11-14)29-21(22,23)24)25-12-15-5-4-6-19(16(15)13-25)30(3,27)28/h4-8,11,26H,9-10,12-13H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
55n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349316
PNG
(US10207991, Ex. Cpd. No. 5)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2cc(Cl)c(Cl)cc2C1
Show InChI InChI=1S/C18H17Cl4N/c1-11(2-3-12-4-5-15(19)16(20)6-12)23-9-13-7-17(21)18(22)8-14(13)10-23/h4-8,11H,2-3,9-10H2,1H3/t11-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
56n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349543
PNG
(US10207991, Ex. Cpd. No. 59)
Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1
Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
57n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349516
PNG
(US10207991, Ex. Cpd. No. 31)
Show SMILES C[C@H](CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H19F4NO2/c1-12(24-10-14-5-6-16(20)9-15(14)11-24)2-3-13-4-7-17(25)18(8-13)26-19(21,22)23/h4-9,12,25H,2-3,10-11H2,1H3/t12-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
58n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349523
PNG
(US10207991, Ex. Cpd. No. 39)
Show SMILES CC(C)Oc1ccc(CC[C@@H](C)N2Cc3cccc(F)c3C2)cc1OC(C)C
Show InChI InChI=1S/C24H32FNO2/c1-16(2)27-23-12-11-19(13-24(23)28-17(3)4)10-9-18(5)26-14-20-7-6-8-22(25)21(20)15-26/h6-8,11-13,16-18H,9-10,14-15H2,1-5H3/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
62n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349547
PNG
(US10207991, Ex. Cpd. No. 62)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-14,26H,11-12,15-16H2,1-6H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
63n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349323
PNG
(US10207991, Ex. Cpd. No. 7)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cc(OC)c(OC)cc3C2)ccc1O
Show InChI InChI=1S/C21H27NO4/c1-14(5-6-15-7-8-18(23)19(9-15)24-2)22-12-16-10-20(25-3)21(26-4)11-17(16)13-22/h7-11,14,23H,5-6,12-13H2,1-4H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
68n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM350897
PNG
(US9796672, Example Compound 19)
Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc3ccccc3c2C1
Show InChI InChI=1S/C22H21Cl2N/c1-15(6-7-16-8-11-21(23)22(24)12-16)25-13-18-10-9-17-4-2-3-5-19(17)20(18)14-25/h2-5,8-12,15H,6-7,13-14H2,1H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
69n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349569
PNG
(US10207991, Ex. Cpd. No. 87)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-17(2)16-29-23-12-18(6-9-22(23)26)10-11-24(3,4)25-14-19-7-8-21(30(5,27)28)13-20(19)15-25/h6-9,12-13,17,26H,10-11,14-16H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
69n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349512
PNG
(US10207991, Ex. Cpd. No. 27)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3ccc(F)cc3C2)ccc1O
Show InChI InChI=1S/C22H28FNO2/c1-15(2)26-21-11-16(5-8-20(21)25)9-10-22(3,4)24-13-17-6-7-19(23)12-18(17)14-24/h5-8,11-12,15,25H,9-10,13-14H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
71n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349538
PNG
(US10207991, Ex. Cpd. No. 54)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C20H21F4NO2/c1-19(2,25-11-14-4-3-5-16(21)15(14)12-25)9-8-13-6-7-17(26)18(10-13)27-20(22,23)24/h3-7,10,26H,8-9,11-12H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
74n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349545
PNG
(US10207991, Ex. Cpd. No. 60B)
Show SMILES C[C@H](CCc1ccc(O)c(OC(C)(C)C)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C22H28FNO2/c1-15(24-13-17-6-5-7-19(23)18(17)14-24)8-9-16-10-11-20(25)21(12-16)26-22(2,3)4/h5-7,10-12,15,25H,8-9,13-14H2,1-4H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
76n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349554
PNG
(US10207991, Ex. Cpd. No. 69)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C22H29NO4S/c1-15(2)27-22-11-17(7-10-21(22)24)6-5-16(3)23-13-18-8-9-20(28(4,25)26)12-19(18)14-23/h7-12,15-16,24H,5-6,13-14H2,1-4H3/t16-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
76n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349535
PNG
(US10207991, Ex. Cpd. No. 51)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1OCCO
Show InChI InChI=1S/C21H26FNO3/c1-15(23-13-17-4-3-5-19(22)18(17)14-23)6-7-16-8-9-20(26-11-10-24)21(12-16)25-2/h3-5,8-9,12,15,24H,6-7,10-11,13-14H2,1-2H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
77n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349324
PNG
(US10207991, Ex. Cpd. No. 8)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C19H22FNO2/c1-13(6-7-14-8-9-18(22)19(10-14)23-2)21-11-15-4-3-5-17(20)16(15)12-21/h3-5,8-10,13,22H,6-7,11-12H2,1-2H3/t13-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
79n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349530
PNG
(US10207991, Ex. Cpd. No. 46)
Show SMILES COC[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H20Cl2FNO/c1-24-12-17(6-2-13-3-7-18(20)19(21)8-13)23-10-14-4-5-16(22)9-15(14)11-23/h3-5,7-9,17H,2,6,10-12H2,1H3/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
94n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349541
PNG
(US10207991, Ex. Cpd. No. 57)
Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27F3N2O3/c1-22(2,11-10-15-8-9-19(29)20(12-15)31-23(24,25)26)28-13-16-6-5-7-17(18(16)14-28)21(30)27(3)4/h5-9,12,29H,10-11,13-14H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
95n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349570
PNG
(US10207991, Ex. Cpd. No. 88)
Show SMILES CC(C)COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C23H30FNO2/c1-16(2)15-27-22-12-17(8-9-21(22)26)10-11-23(3,4)25-13-18-6-5-7-20(24)19(18)14-25/h5-9,12,16,26H,10-11,13-15H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
96n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349553
PNG
(US10207991, Ex. Cpd. No. 68)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C20H25NO4S/c1-14(4-5-15-6-9-19(22)20(10-15)25-2)21-12-16-7-8-18(26(3,23)24)11-17(16)13-21/h6-11,14,22H,4-5,12-13H2,1-3H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
100n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349571
PNG
(US10207991, Ex. Cpd. No. 95)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)n2cc3ccc(cc3c2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H31NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-16,26H,11-12H2,1-6H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
100n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349526
PNG
(US10207991, Ex. Cpd. No. 42)
Show SMILES CC(C)Oc1ccc(CCC(C)(C)N2Cc3ccc(F)cc3C2)cc1OC(C)C
Show InChI InChI=1S/C25H34FNO2/c1-17(2)28-23-10-7-19(13-24(23)29-18(3)4)11-12-25(5,6)27-15-20-8-9-22(26)14-21(20)16-27/h7-10,13-14,17-18H,11-12,15-16H2,1-6H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
100n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349510
PNG
(US10207991, Ex. Cpd. No. 25)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)ccc1O
Show InChI InChI=1S/C22H27NO4/c1-14(2)27-20-8-16(6-7-19(20)24)5-4-15(3)23-11-17-9-21-22(26-13-25-21)10-18(17)12-23/h6-10,14-15,24H,4-5,11-13H2,1-3H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
110n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349537
PNG
(US10207991, Ex. Cpd. No. 53)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C20H24FNO2/c1-20(2,10-9-14-7-8-18(23)19(11-14)24-3)22-12-15-5-4-6-17(21)16(15)13-22/h4-8,11,23H,9-10,12-13H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
110n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349513
PNG
(US10207991, Ex. Cpd. No. 28)
Show SMILES CC(C)Oc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C22H28FNO2/c1-15(2)26-21-12-16(8-9-20(21)25)10-11-22(3,4)24-13-17-6-5-7-19(23)18(17)14-24/h5-9,12,15,25H,10-11,13-14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
120n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349536
PNG
(US10207991, Ex. Cpd. No. 52)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)ccc1OCCO
Show InChI InChI=1S/C22H27NO5/c1-15(3-4-16-5-6-19(26-8-7-24)20(9-16)25-2)23-12-17-10-21-22(28-14-27-21)11-18(17)13-23/h5-6,9-11,15,24H,3-4,7-8,12-14H2,1-2H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
130n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349551
PNG
(US10207991, Ex. Cpd. No. 66)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-21-14-17(10-11-20(21)26)12-13-24(4,5)25-15-18-8-7-9-22(19(18)16-25)30(6,27)28/h7-11,14,26H,12-13,15-16H2,1-6H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
130n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349531
PNG
(US10207991, Ex. Cpd. No. 47)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cc4OCOc4cc3C2)ccc1OCCO
Show InChI InChI=1S/C23H29NO5/c1-23(2,7-6-16-4-5-19(27-9-8-25)20(10-16)26-3)24-13-17-11-21-22(29-15-28-21)12-18(17)14-24/h4-5,10-12,25H,6-9,13-15H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
140n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349521
PNG
(US10207991, Ex. Cpd. No. 37)
Show SMILES CC(C)Oc1cc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)ccc1O
Show InChI InChI=1S/C21H26FNO2/c1-14(2)25-21-10-16(6-9-20(21)24)5-4-15(3)23-12-17-7-8-19(22)11-18(17)13-23/h6-11,14-15,24H,4-5,12-13H2,1-3H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
140n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349528
PNG
(US10207991, Ex. Cpd. No. 44)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1OCCO
Show InChI InChI=1S/C22H28FNO3/c1-22(2,24-14-17-5-4-6-19(23)18(17)15-24)10-9-16-7-8-20(27-12-11-25)21(13-16)26-3/h4-8,13,25H,9-12,14-15H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
140n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349527
PNG
(US10207991, Ex. Cpd. No. 43)
Show SMILES C[C@H](CCc1ccc(OC(=O)N(C)C)c(OC(F)(F)F)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C22H24F4N2O3/c1-14(28-12-16-7-8-18(23)11-17(16)13-28)4-5-15-6-9-19(30-21(29)27(2)3)20(10-15)31-22(24,25)26/h6-11,14H,4-5,12-13H2,1-3H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
140n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349556
PNG
(US10207991, Ex. Cpd. No. 73)
Show SMILES C[C@H](CCc1ccc(OCCO)c(OC(F)(F)F)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C21H23F4NO3/c1-14(26-12-16-5-6-18(22)11-17(16)13-26)2-3-15-4-7-19(28-9-8-27)20(10-15)29-21(23,24)25/h4-7,10-11,14,27H,2-3,8-9,12-13H2,1H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
140n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349530
PNG
(US10207991, Ex. Cpd. No. 46)
Show SMILES COC[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C19H20Cl2FNO/c1-24-12-17(6-2-13-3-7-18(20)19(21)8-13)23-10-14-4-5-16(22)9-15(14)11-23/h3-5,7-9,17H,2,6,10-12H2,1H3/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
160n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349580
PNG
(US10207991, Ex. Cpd. No. 105)
Show SMILES CC(C)(CCc1ccc(Cl)cc1)N1Cc2cccc(C(=O)N3CCNCC3)c2C1
Show InChI InChI=1S/C24H30ClN3O/c1-24(2,11-10-18-6-8-20(25)9-7-18)28-16-19-4-3-5-21(22(19)17-28)23(29)27-14-12-26-13-15-27/h3-9,26H,10-17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
180n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349549
PNG
(US10207991, Ex. Cpd. No. 64)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C21H27NO4S/c1-21(2,11-10-15-8-9-18(23)19(12-15)26-3)22-13-16-6-5-7-20(17(16)14-22)27(4,24)25/h5-9,12,23H,10-11,13-14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
180n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349550
PNG
(US10207991, Ex. Cpd. No. 65)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C20H25NO4S/c1-14(7-8-15-9-10-18(22)19(11-15)25-2)21-12-16-5-4-6-20(17(16)13-21)26(3,23)24/h4-6,9-11,14,22H,7-8,12-13H2,1-3H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
190n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349529
PNG
(US10207991, Ex. Cpd. No. 45)
Show SMILES COc1cc(CCC(C)(C)N2Cc3ccc(F)cc3C2)ccc1OCCO
Show InChI InChI=1S/C22H28FNO3/c1-22(2,24-14-17-5-6-19(23)13-18(17)15-24)9-8-16-4-7-20(27-11-10-25)21(12-16)26-3/h4-7,12-13,25H,8-11,14-15H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
190n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349515
PNG
(US10207991, Ex. Cpd. No. 30)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)ccc1OCCO
Show InChI InChI=1S/C21H26FNO3/c1-15(23-13-17-6-7-19(22)12-18(17)14-23)3-4-16-5-8-20(26-10-9-24)21(11-16)25-2/h5-8,11-12,15,24H,3-4,9-10,13-14H2,1-2H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
220n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349268
PNG
(US10207991, Ex. Cpd. No. 3)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cc(Cl)c(Cl)cc3C2)ccc1O
Show InChI InChI=1S/C19H21Cl2NO2/c1-12(3-4-13-5-6-18(23)19(7-13)24-2)22-10-14-8-16(20)17(21)9-15(14)11-22/h5-9,12,23H,3-4,10-11H2,1-2H3/t12-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
240n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349542
PNG
(US10207991, Ex. Cpd. No. 58)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1O
Show InChI InChI=1S/C23H30FNO2/c1-22(2,3)27-21-13-16(9-10-20(21)26)11-12-23(4,5)25-14-17-7-6-8-19(24)18(17)15-25/h6-10,13,26H,11-12,14-15H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
240n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349581
PNG
(US10207991, Ex. Cpd. No. 106)
Show SMILES CC(C)(CCc1ccc(Cl)c(Cl)c1)N1Cc2cccc(C(=O)N3CCNCC3)c2C1
Show InChI InChI=1S/C24H29Cl2N3O/c1-24(2,9-8-17-6-7-21(25)22(26)14-17)29-15-18-4-3-5-19(20(18)16-29)23(30)28-12-10-27-11-13-28/h3-7,14,27H,8-13,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
240n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349539
PNG
(US10207991, Ex. Cpd. No. 55)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2c(C1)c(F)ccc2F
Show InChI InChI=1S/C20H20F5NO2/c1-19(2,26-10-13-14(11-26)16(22)5-4-15(13)21)8-7-12-3-6-17(27)18(9-12)28-20(23,24)25/h3-6,9,27H,7-8,10-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
310n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349506
PNG
(US10207991, Ex. Cpd. No. 21)
Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
330n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349567
PNG
(US10207991, Ex. Cpd. No. 85)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N(C)CCO)c3C2)ccc1O
Show InChI InChI=1S/C24H32N2O4/c1-24(2,11-10-17-8-9-21(28)22(14-17)30-4)26-15-18-6-5-7-19(20(18)16-26)23(29)25(3)12-13-27/h5-9,14,27-28H,10-13,15-16H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
360n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349539
PNG
(US10207991, Ex. Cpd. No. 55)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2c(C1)c(F)ccc2F
Show InChI InChI=1S/C20H20F5NO2/c1-19(2,26-10-13-14(11-26)16(22)5-4-15(13)21)8-7-12-3-6-17(27)18(9-12)28-20(23,24)25/h3-6,9,27H,7-8,10-11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
360n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349548
PNG
(US10207991, Ex. Cpd. No. 63)
Show SMILES C[C@H](CCc1ccc(O)c(OC(C)(C)C)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C23H31NO4S/c1-16(6-7-17-8-11-21(25)22(12-17)28-23(2,3)4)24-14-18-9-10-20(29(5,26)27)13-19(18)15-24/h8-13,16,25H,6-7,14-15H2,1-5H3/t16-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
380n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349527
PNG
(US10207991, Ex. Cpd. No. 43)
Show SMILES C[C@H](CCc1ccc(OC(=O)N(C)C)c(OC(F)(F)F)c1)N1Cc2ccc(F)cc2C1
Show InChI InChI=1S/C22H24F4N2O3/c1-14(28-12-16-7-8-18(23)11-17(16)13-28)4-5-15-6-9-19(30-21(29)27(2)3)20(10-15)31-22(24,25)26/h6-11,14H,4-5,12-13H2,1-3H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
380n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349553
PNG
(US10207991, Ex. Cpd. No. 68)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C20H25NO4S/c1-14(4-5-15-6-9-19(22)20(10-15)25-2)21-12-16-7-8-18(26(3,23)24)11-17(16)13-21/h6-11,14,22H,4-5,12-13H2,1-3H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
400n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349544
PNG
(US10207991, Ex. Cpd. No. 60A)
Show SMILES C[C@H](CCc1ccc(O)c(OC(C)(C)C)c1)N1Cc2c(C1)c(F)ccc2F
Show InChI InChI=1S/C22H27F2NO2/c1-14(25-12-16-17(13-25)19(24)9-8-18(16)23)5-6-15-7-10-20(26)21(11-15)27-22(2,3)4/h7-11,14,26H,5-6,12-13H2,1-4H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
410n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349561
PNG
(US10207991, Ex. Cpd. No. 79)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)NCCO)c3C2)ccc1O
Show InChI InChI=1S/C23H30N2O4/c1-23(2,10-9-16-7-8-20(27)21(13-16)29-3)25-14-17-5-4-6-18(19(17)15-25)22(28)24-11-12-26/h4-8,13,26-27H,9-12,14-15H2,1-3H3,(H,24,28)
UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
460n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349533
PNG
(US10207991, Ex. Cpd. No. 49)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1OC(=O)N(C)C
Show InChI InChI=1S/C23H29FN2O3/c1-23(2,26-14-17-7-6-8-19(24)18(17)15-26)12-11-16-9-10-20(21(13-16)28-5)29-22(27)25(3)4/h6-10,13H,11-12,14-15H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
470n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349525
PNG
(US10207991, Ex. Cpd. No. 41)
Show SMILES C[C@H](CCc1ccc(OC(=O)N(C)C)c(OC(F)(F)F)c1)N1Cc2cccc(F)c2C1
Show InChI InChI=1S/C22H24F4N2O3/c1-14(28-12-16-5-4-6-18(23)17(16)13-28)7-8-15-9-10-19(30-21(29)27(2)3)20(11-15)31-22(24,25)26/h4-6,9-11,14H,7-8,12-13H2,1-3H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
520n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349536
PNG
(US10207991, Ex. Cpd. No. 52)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cc4OCOc4cc3C2)ccc1OCCO
Show InChI InChI=1S/C22H27NO5/c1-15(3-4-16-5-6-19(26-8-7-24)20(9-16)25-2)23-12-17-10-21-22(28-14-27-21)11-18(17)13-23/h5-6,9-11,15,24H,3-4,7-8,12-14H2,1-2H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
540n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349557
PNG
(US10207991, Ex. Cpd. No. 74)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3c(C2)c(F)ccc3F)ccc1O
Show InChI InChI=1S/C23H29F2NO2/c1-22(2,3)28-21-12-15(6-9-20(21)27)10-11-23(4,5)26-13-16-17(14-26)19(25)8-7-18(16)24/h6-9,12,27H,10-11,13-14H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
550n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349541
PNG
(US10207991, Ex. Cpd. No. 57)
Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27F3N2O3/c1-22(2,11-10-15-8-9-19(29)20(12-15)31-23(24,25)26)28-13-16-6-5-7-17(18(16)14-28)21(30)27(3)4/h5-9,12,29H,10-11,13-14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
700n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349586
PNG
(US10207991, Ex. Cpd. No. 111)
Show SMILES COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)N2CCNCC2)ccc1O
Show InChI InChI=1S/C24H33N3O2/c1-24(2,9-8-18-4-7-22(28)23(14-18)29-3)27-16-19-5-6-21(15-20(19)17-27)26-12-10-25-11-13-26/h4-7,14-15,25,28H,8-13,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
740n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349534
PNG
(US10207991, Ex. Cpd. No. 50)
Show SMILES COc1cc(CCC(C)(C)N2Cc3ccc(F)cc3C2)ccc1OC(=O)N(C)C
Show InChI InChI=1S/C23H29FN2O3/c1-23(2,26-14-17-7-8-19(24)13-18(17)15-26)11-10-16-6-9-20(21(12-16)28-5)29-22(27)25(3)4/h6-9,12-13H,10-11,14-15H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
750n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349579
PNG
(US10207991, Ex. Cpd. No. 104)
Show SMILES COc1cccc(CCC(C)(C)n2cc3ccc(cc3c2)S(C)(=O)=O)c1
Show InChI InChI=1S/C21H25NO3S/c1-21(2,11-10-16-6-5-7-19(12-16)25-3)22-14-17-8-9-20(26(4,23)24)13-18(17)15-22/h5-9,12-15H,10-11H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
760n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349535
PNG
(US10207991, Ex. Cpd. No. 51)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1OCCO
Show InChI InChI=1S/C21H26FNO3/c1-15(23-13-17-4-3-5-19(22)18(17)14-23)6-7-16-8-9-20(26-11-10-24)21(12-16)25-2/h3-5,8-9,12,15,24H,6-7,10-11,13-14H2,1-2H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
800n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349515
PNG
(US10207991, Ex. Cpd. No. 30)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)ccc1OCCO
Show InChI InChI=1S/C21H26FNO3/c1-15(23-13-17-6-7-19(22)12-18(17)14-23)3-4-16-5-8-20(26-10-9-24)21(11-16)25-2/h5-8,11-12,15,24H,3-4,9-10,13-14H2,1-2H3/t15-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
910n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349531
PNG
(US10207991, Ex. Cpd. No. 47)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cc4OCOc4cc3C2)ccc1OCCO
Show InChI InChI=1S/C23H29NO5/c1-23(2,7-6-16-4-5-19(27-9-8-25)20(10-16)26-3)24-13-17-11-21-22(29-15-28-21)12-18(17)14-24/h4-5,10-12,25H,6-9,13-15H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349574
PNG
(US10207991, Ex. Cpd. No. 99)
Show SMILES COc1ccc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)cc1
Show InChI InChI=1S/C25H33N3O2/c1-25(2,12-11-19-7-9-21(30-3)10-8-19)28-17-20-5-4-6-22(23(20)18-28)24(29)27-15-13-26-14-16-27/h4-10,26H,11-18H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.20E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349528
PNG
(US10207991, Ex. Cpd. No. 44)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1OCCO
Show InChI InChI=1S/C22H28FNO3/c1-22(2,24-14-17-5-4-6-19(23)18(17)15-24)10-9-16-7-8-20(27-12-11-25)21(13-16)26-3/h4-8,13,25H,9-12,14-15H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.30E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349550
PNG
(US10207991, Ex. Cpd. No. 65)
Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Show InChI InChI=1S/C20H25NO4S/c1-14(7-8-15-9-10-18(22)19(11-15)25-2)21-12-16-5-4-6-20(17(16)13-21)26(3,23)24/h4-6,9-11,14,22H,7-8,12-13H2,1-3H3/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.30E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349562
PNG
(US10207991, Ex. Cpd. No. 80)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCOCC4)c3C2)ccc1O
Show InChI InChI=1S/C25H32N2O4/c1-25(2,10-9-18-7-8-22(28)23(15-18)30-3)27-16-19-5-4-6-20(21(19)17-27)24(29)26-11-13-31-14-12-26/h4-8,15,28H,9-14,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.40E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349544
PNG
(US10207991, Ex. Cpd. No. 60A)
Show SMILES C[C@H](CCc1ccc(O)c(OC(C)(C)C)c1)N1Cc2c(C1)c(F)ccc2F
Show InChI InChI=1S/C22H27F2NO2/c1-14(25-12-16-17(13-25)19(24)9-8-18(16)23)5-6-15-7-10-20(26)21(11-15)27-22(2,3)4/h7-11,14,26H,5-6,12-13H2,1-4H3/t14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.60E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349557
PNG
(US10207991, Ex. Cpd. No. 74)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3c(C2)c(F)ccc3F)ccc1O
Show InChI InChI=1S/C23H29F2NO2/c1-22(2,3)28-21-12-15(6-9-20(21)27)10-11-23(4,5)26-13-16-17(14-26)19(25)8-7-18(16)24/h6-9,12,27H,10-11,13-14H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.30E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349529
PNG
(US10207991, Ex. Cpd. No. 45)
Show SMILES COc1cc(CCC(C)(C)N2Cc3ccc(F)cc3C2)ccc1OCCO
Show InChI InChI=1S/C22H28FNO3/c1-22(2,24-14-17-5-6-19(23)13-18(17)15-24)9-8-16-4-7-20(27-11-10-25)21(12-16)26-3/h4-7,12-13,25H,8-11,14-15H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.80E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349532
PNG
(US10207991, Ex. Cpd. No. 48)
Show SMILES COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(OCCO)c(OC)c1
Show InChI InChI=1S/C24H33NO5/c1-24(2,9-8-17-6-7-20(30-11-10-26)21(12-17)27-3)25-15-18-13-22(28-4)23(29-5)14-19(18)16-25/h6-7,12-14,26H,8-11,15-16H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
3.60E+3n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349560
PNG
(US10207991, Ex. Cpd. No. 78)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)NCCN(C)C)c3C2)ccc1O
Show InChI InChI=1S/C25H35N3O3/c1-25(2,12-11-18-9-10-22(29)23(15-18)31-5)28-16-19-7-6-8-20(21(19)17-28)24(30)26-13-14-27(3)4/h6-10,15,29H,11-14,16-17H2,1-5H3,(H,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349582
PNG
(US10207991, Ex. Cpd. No. 107)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(N4CCNCC4)c3C2)ccc1O
Show InChI InChI=1S/C24H33N3O2/c1-24(2,10-9-18-7-8-22(28)23(15-18)29-3)27-16-19-5-4-6-21(20(19)17-27)26-13-11-25-12-14-26/h4-8,15,25,28H,9-14,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349543
PNG
(US10207991, Ex. Cpd. No. 59)
Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1
Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349563
PNG
(US10207991, Ex. Cpd. No. 81)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N(C)CCN(C)C)c3C2)ccc1O
Show InChI InChI=1S/C26H37N3O3/c1-26(2,13-12-19-10-11-23(30)24(16-19)32-6)29-17-20-8-7-9-21(22(20)18-29)25(31)28(5)15-14-27(3)4/h7-11,16,30H,12-15,17-18H2,1-6H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM350934
PNG
(US9796672, Example Compound 56)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(OC=O)c2C1
Show InChI InChI=1S/C21H22F3NO4/c1-20(2,25-11-15-4-3-5-18(28-13-26)16(15)12-25)9-8-14-6-7-17(27)19(10-14)29-21(22,23)24/h3-7,10,13,27H,8-9,11-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349559
PNG
(US10207991, Ex. Cpd. No. 76)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)ccc1O
Show InChI InChI=1S/C25H33N3O3/c1-25(2,10-9-18-7-8-22(29)23(15-18)31-3)28-16-19-5-4-6-20(21(19)17-28)24(30)27-13-11-26-12-14-27/h4-8,15,26,29H,9-14,16-17H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349561
PNG
(US10207991, Ex. Cpd. No. 79)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)NCCO)c3C2)ccc1O
Show InChI InChI=1S/C23H30N2O4/c1-23(2,10-9-16-7-8-20(27)21(13-16)29-3)25-14-17-5-4-6-18(19(17)15-25)22(28)24-11-12-26/h4-8,13,26-27H,9-12,14-15H2,1-3H3,(H,24,28)
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349562
PNG
(US10207991, Ex. Cpd. No. 80)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCOCC4)c3C2)ccc1O
Show InChI InChI=1S/C25H32N2O4/c1-25(2,10-9-18-7-8-22(28)23(15-18)30-3)27-16-19-5-4-6-20(21(19)17-27)24(29)26-11-13-31-14-12-26/h4-8,15,28H,9-14,16-17H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349566
PNG
(US10207991, Ex. Cpd. No. 84)
Show SMILES COCCNC(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C24H32N2O4/c1-24(2,11-10-17-8-9-21(27)22(14-17)30-4)26-15-18-6-5-7-19(20(18)16-26)23(28)25-12-13-29-3/h5-9,14,27H,10-13,15-16H2,1-4H3,(H,25,28)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349560
PNG
(US10207991, Ex. Cpd. No. 78)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)NCCN(C)C)c3C2)ccc1O
Show InChI InChI=1S/C25H35N3O3/c1-25(2,12-11-18-9-10-22(29)23(15-18)31-5)28-16-19-7-6-8-20(21(19)17-28)24(30)26-13-14-27(3)4/h6-10,15,29H,11-14,16-17H2,1-5H3,(H,26,30)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349564
PNG
(US10207991, Ex. Cpd. No. 82)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCN(C)CC4)c3C2)ccc1O
Show InChI InChI=1S/C26H35N3O3/c1-26(2,11-10-19-8-9-23(30)24(16-19)32-4)29-17-20-6-5-7-21(22(20)18-29)25(31)28-14-12-27(3)13-15-28/h5-9,16,30H,10-15,17-18H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349565
PNG
(US10207991, Ex. Cpd. No. 83)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCN(CC4)C(C)=O)c3C2)ccc1O
Show InChI InChI=1S/C27H35N3O4/c1-19(31)28-12-14-29(15-13-28)26(33)22-7-5-6-21-17-30(18-23(21)22)27(2,3)11-10-20-8-9-24(32)25(16-20)34-4/h5-9,16,32H,10-15,17-18H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349566
PNG
(US10207991, Ex. Cpd. No. 84)
Show SMILES COCCNC(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C24H32N2O4/c1-24(2,11-10-17-8-9-21(27)22(14-17)30-4)26-15-18-6-5-7-19(20(18)16-26)23(28)25-12-13-29-3/h5-9,14,27H,10-13,15-16H2,1-4H3,(H,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349585
PNG
(US10207991, Ex. Cpd. No. 110)
Show SMILES CC(C)(C#Cc1ccc2[nH]ncc2c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Show InChI InChI=1S/C21H21N3O2S/c1-21(2,9-8-15-4-7-20-17(10-15)12-22-23-20)24-13-16-5-6-19(27(3,25)26)11-18(16)14-24/h4-7,10-12H,13-14H2,1-3H3,(H,22,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349567
PNG
(US10207991, Ex. Cpd. No. 85)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N(C)CCO)c3C2)ccc1O
Show InChI InChI=1S/C24H32N2O4/c1-24(2,11-10-17-8-9-21(28)22(14-17)30-4)26-15-18-6-5-7-19(20(18)16-26)23(29)25(3)12-13-27/h5-9,14,27-28H,10-13,15-16H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349568
PNG
(US10207991, Ex. Cpd. No. 86)
Show SMILES COCCN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C25H34N2O4/c1-25(2,12-11-18-9-10-22(28)23(15-18)31-5)27-16-19-7-6-8-20(21(19)17-27)24(29)26(3)13-14-30-4/h6-10,15,28H,11-14,16-17H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349573
PNG
(US10207991, Ex. Cpd. No. 98)
Show SMILES COc1cccc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)c1
Show InChI InChI=1S/C25H33N3O2/c1-25(2,11-10-19-6-4-8-21(16-19)30-3)28-17-20-7-5-9-22(23(20)18-28)24(29)27-14-12-26-13-15-27/h4-9,16,26H,10-15,17-18H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349575
PNG
(US10207991, Ex. Cpd. No. 100)
Show SMILES COc1ccc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCNCC4)c3C2)cc1OC
Show InChI InChI=1S/C26H35N3O3/c1-26(2,11-10-19-8-9-23(31-3)24(16-19)32-4)29-17-20-6-5-7-21(22(20)18-29)25(30)28-14-12-27-13-15-28/h5-9,16,27H,10-15,17-18H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM350934
PNG
(US9796672, Example Compound 56)
Show SMILES CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2cccc(OC=O)c2C1
Show InChI InChI=1S/C21H22F3NO4/c1-20(2,25-11-15-4-3-5-18(28-13-26)16(15)12-25)9-8-14-6-7-17(27)19(10-14)29-21(22,23)24/h3-7,10,13,27H,8-9,11-12H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349558
PNG
(US10207991, Ex. Cpd. No. 75)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(C(O)=O)c3C2)ccc1O
Show InChI InChI=1S/C24H31NO4/c1-23(2,3)29-21-13-16(9-10-20(21)26)11-12-24(4,5)25-14-17-7-6-8-18(22(27)28)19(17)15-25/h6-10,13,26H,11-12,14-15H2,1-5H3,(H,27,28)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349558
PNG
(US10207991, Ex. Cpd. No. 75)
Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(C(O)=O)c3C2)ccc1O
Show InChI InChI=1S/C24H31NO4/c1-23(2,3)29-21-13-16(9-10-20(21)26)11-12-24(4,5)25-14-17-7-6-8-18(22(27)28)19(17)15-25/h6-10,13,26H,11-12,14-15H2,1-5H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349563
PNG
(US10207991, Ex. Cpd. No. 81)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N(C)CCN(C)C)c3C2)ccc1O
Show InChI InChI=1S/C26H37N3O3/c1-26(2,13-12-19-10-11-23(30)24(16-19)32-6)29-17-20-8-7-9-21(22(20)18-29)25(31)28(5)15-14-27(3)4/h7-11,16,30H,12-15,17-18H2,1-6H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349564
PNG
(US10207991, Ex. Cpd. No. 82)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCN(C)CC4)c3C2)ccc1O
Show InChI InChI=1S/C26H35N3O3/c1-26(2,11-10-19-8-9-23(30)24(16-19)32-4)29-17-20-6-5-7-21(22(20)18-29)25(31)28-14-12-27(3)13-15-28/h5-9,16,30H,10-15,17-18H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Homo sapiens (Human))
BDBM349565
PNG
(US10207991, Ex. Cpd. No. 83)
Show SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)N4CCN(CC4)C(C)=O)c3C2)ccc1O
Show InChI InChI=1S/C27H35N3O4/c1-19(31)28-12-14-29(15-13-28)26(33)22-7-5-6-21-17-30(18-23(21)22)27(2,3)11-10-20-8-9-24(32)25(16-20)34-4/h5-9,16,32H,10-15,17-18H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM349568
PNG
(US10207991, Ex. Cpd. No. 86)
Show SMILES COCCN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C25H34N2O4/c1-25(2,12-11-18-9-10-22(28)23(15-18)31-5)27-16-19-7-6-8-20(21(19)17-27)24(29)26(3)13-14-30-4/h6-10,15,28H,11-14,16-17H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+4n/an/an/an/an/an/an/an/a



COGNITION THERAPEUTICS, INC.

US Patent


Assay Description
Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...


US Patent US9796672 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%