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Patent code US9796704

Compile Data Set for Download or QSAR

Found 1540 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351507
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [2-(m...)
Show SMILES COc1ccccc1-c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)no1
Show InChI InChI=1S/C25H19Cl2N5O4/c1-33-20-6-4-3-5-15(20)25-31-23(32-36-25)12-35-22-11-19-16(10-21(22)34-2)24(29-13-28-19)30-14-7-8-17(26)18(27)9-14/h3-11,13H,12H2,1-2H3,(H,28,29,30)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHA2)


(Homo sapiens (Human))
BDBM351281
PNG
(N-(3,4-dichloro-2-fluorophenyl)-7- ({[(3aR,5r,6aS)...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(C[C@H]2C1)C(C)C
Show InChI InChI=1S/C26H29Cl2FN4O2/c1-14(2)33-10-16-6-15(7-17(16)11-33)12-35-23-9-21-18(8-22(23)34-3)26(31-13-30-21)32-20-5-4-19(27)24(28)25(20)29/h4-5,8-9,13-17H,6-7,10-12H2,1-3H3,(H,30,31,32)/t15-,16-,17+
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351307
PNG
(N-(3-chloro-2,4-difluorophenyl)-7-{[(3S,8aS)- hexa...)
Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN2CCC[C@H]2CO1
Show InChI InChI=1S/C23H23ClF2N4O3/c1-31-19-7-15-18(8-20(19)33-11-14-9-30-6-2-3-13(30)10-32-14)27-12-28-23(15)29-17-5-4-16(25)21(24)22(17)26/h4-5,7-8,12-14H,2-3,6,9-11H2,1H3,(H,27,28,29)/t13-,14-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM351517
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-{[2- (1-met...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCCC1CCCN1C
Show InChI InChI=1S/C22H24Cl2N4O2/c1-28-8-3-4-15(28)7-9-30-21-12-19-16(11-20(21)29-2)22(26-13-25-19)27-14-5-6-17(23)18(24)10-14/h5-6,10-13,15H,3-4,7-9H2,1-2H3,(H,25,26,27)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351525
PNG
(US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1
Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHA2)


(Homo sapiens (Human))
BDBM351525
PNG
(US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1
Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM351525
PNG
(US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1
Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351287
PNG
(N-(4-bromo-5-chloro-2-fluorophenyl)-7- ({[(3aR,5s,...)
Show SMILES COc1cc2c(Nc3cc(Cl)c(Br)cc3F)ncnc2cc1OC[C@@H]1C[C@H]2CN(C)C[C@H]2C1
Show InChI InChI=1S/C24H25BrClFN4O2/c1-31-9-14-3-13(4-15(14)10-31)11-33-23-8-20-16(5-22(23)32-2)24(29-12-28-20)30-21-7-18(26)17(25)6-19(21)27/h5-8,12-15H,3-4,9-11H2,1-2H3,(H,28,29,30)/t13-,14+,15-
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351290
PNG
(N-(4-bromo-3-chloro-2-fluorophenyl)-7- ({[(3aR,5r,...)
Show SMILES CCN1C[C@@H]2C[C@H](COc3cc4ncnc(Nc5ccc(Br)c(Cl)c5F)c4cc3OC)C[C@@H]2C1
Show InChI InChI=1S/C25H27BrClFN4O2/c1-3-32-10-15-6-14(7-16(15)11-32)12-34-22-9-20-17(8-21(22)33-2)25(30-13-29-20)31-19-5-4-18(26)23(27)24(19)28/h4-5,8-9,13-16H,3,6-7,10-12H2,1-2H3,(H,29,30,31)/t14-,15-,16+
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351323
PNG
(N-(3,4-dichlorophenyl)-7-{[(8-methyl-8- azabicyclo...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CC2CCC(C1)N2C
Show InChI InChI=1S/C24H26Cl2N4O2/c1-30-16-4-5-17(30)8-14(7-16)12-32-23-11-21-18(10-22(23)31-2)24(28-13-27-21)29-15-3-6-19(25)20(26)9-15/h3,6,9-11,13-14,16-17H,4-5,7-8,12H2,1-2H3,(H,27,28,29)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351326
PNG
(1,4:3,6-dianhydro-2-O-[4-[(4-bromo-5-chloro- 2-flu...)
Show SMILES CO[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3cc(Cl)c(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C22H20BrClFN3O5/c1-29-16-3-10-14(6-17(16)33-19-8-32-20-18(30-2)7-31-21(19)20)26-9-27-22(10)28-15-5-12(24)11(23)4-13(15)25/h3-6,9,18-21H,7-8H2,1-2H3,(H,26,27,28)/t18-,19-,20+,21+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351326
PNG
(1,4:3,6-dianhydro-2-O-[4-[(4-bromo-5-chloro- 2-flu...)
Show SMILES CO[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3cc(Cl)c(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C22H20BrClFN3O5/c1-29-16-3-10-14(6-17(16)33-19-8-32-20-18(30-2)7-31-21(19)20)26-9-27-22(10)28-15-5-12(24)11(23)4-13(15)25/h3-6,9,18-21H,7-8H2,1-2H3,(H,26,27,28)/t18-,19-,20+,21+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351529
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-{[(2- piper...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCCN1
Show InChI InChI=1S/C24H23Cl2N5O2S/c1-32-21-9-16-20(28-13-29-23(16)30-14-5-6-17(25)18(26)8-14)10-22(21)33-11-15-12-34-24(31-15)19-4-2-3-7-27-19/h5-6,8-10,12-13,19,27H,2-4,7,11H2,1H3,(H,28,29,30)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351534
PNG
(N-(3,4-dichlorophenyl)-7-[({3-[(2S)-1- ethylpyrrol...)
Show SMILES CCN1CCCC1c1noc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)n1
Show InChI InChI=1S/C24H24Cl2N6O3/c1-3-32-8-4-5-19(32)24-30-22(35-31-24)12-34-21-11-18-15(10-20(21)33-2)23(28-13-27-18)29-14-6-7-16(25)17(26)9-14/h6-7,9-11,13,19H,3-5,8,12H2,1-2H3,(H,27,28,29)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351535
PNG
(N-(3,4-dichlorophenyl)-7-[({2-[(2S)-1- ethylpyrrol...)
Show SMILES CCN1CCCC1c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1
Show InChI InChI=1S/C25H25Cl2N5O2S/c1-3-32-8-4-5-21(32)25-31-16(13-35-25)12-34-23-11-20-17(10-22(23)33-2)24(29-14-28-20)30-15-6-7-18(26)19(27)9-15/h6-7,9-11,13-14,21H,3-5,8,12H2,1-2H3,(H,28,29,30)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351536
PNG
(N-(3,4-dichlorophenyl)-7-{[(5-ethyl-4,5,6,7- tetra...)
Show SMILES CCC1Cc2nc(COc3cc4ncnc(Nc5ccc(Cl)c(Cl)c5)c4cc3OC)sc2CN1
Show InChI InChI=1S/C24H23Cl2N5O2S/c1-3-13-7-19-22(10-27-13)34-23(31-19)11-33-21-9-18-15(8-20(21)32-2)24(29-12-28-18)30-14-4-5-16(25)17(26)6-14/h4-6,8-9,12-13,27H,3,7,10-11H2,1-2H3,(H,28,29,30)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351291
PNG
(N-(4-bromo-3-chloro-2-fluorophenyl)-6- (methyloxy)...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(CC(C)C)C[C@H]2C1
Show InChI InChI=1S/C27H31BrClFN4O2/c1-15(2)10-34-11-17-6-16(7-18(17)12-34)13-36-24-9-22-19(8-23(24)35-3)27(32-14-31-22)33-21-5-4-20(28)25(29)26(21)30/h4-5,8-9,14-18H,6-7,10-13H2,1-3H3,(H,31,32,33)/t16-,17-,18+
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351292
PNG
(N-(4-bromo-2,3-dichlorophenyl)-7- {[(3R,9aS)-hexah...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3Cl)ncnc2cc1OC[C@H]1CN2CCOCC2CO1
Show InChI InChI=1S/C23H23BrCl2N4O4/c1-31-19-6-15-18(27-12-28-23(15)29-17-3-2-16(24)21(25)22(17)26)7-20(19)34-11-14-8-30-4-5-32-9-13(30)10-33-14/h2-3,6-7,12-14H,4-5,8-11H2,1H3,(H,27,28,29)/t13?,14-/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351294
PNG
(N-(4-bromo-5-chloro-2-fluorophenyl)-7- {[(3R,9aS)-...)
Show SMILES COc1cc2c(Nc3cc(Cl)c(Br)cc3F)ncnc2cc1OC[C@H]1CN2CCOCC2CO1
Show InChI InChI=1S/C23H23BrClFN4O4/c1-31-21-4-15-19(27-12-28-23(15)29-20-6-17(25)16(24)5-18(20)26)7-22(21)34-11-14-8-30-2-3-32-9-13(30)10-33-14/h4-7,12-14H,2-3,8-11H2,1H3,(H,27,28,29)/t13?,14-/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351295
PNG
(N-(3-chloro-2,4-difluorophenyl)-7-{[(3R,9aS)- hexa...)
Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3F)ncnc2cc1OC[C@H]1CN2CCOCC2CO1
Show InChI InChI=1S/C23H23ClF2N4O4/c1-31-19-6-15-18(27-12-28-23(15)29-17-3-2-16(25)21(24)22(17)26)7-20(19)34-11-14-8-30-4-5-32-9-13(30)10-33-14/h2-3,6-7,12-14H,4-5,8-11H2,1H3,(H,27,28,29)/t13?,14-/m1/s1
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n/an/a<50n/an/an/an/an/an/a



SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351298
PNG
(N-(3-chloro-2,4-difluorophenyl)-7-{[(3S,9aS)- hexa...)
Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN2CCOCC2CO1
Show InChI InChI=1S/C23H23ClF2N4O4/c1-31-19-6-15-18(27-12-28-23(15)29-17-3-2-16(25)21(24)22(17)26)7-20(19)34-11-14-8-30-4-5-32-9-13(30)10-33-14/h2-3,6-7,12-14H,4-5,8-11H2,1H3,(H,27,28,29)/t13?,14-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351300
PNG
(N-(4,5-dichloro-2-fluorophenyl)-7-{[(3S,9aS)- hexa...)
Show SMILES COc1cc2c(Nc3cc(Cl)c(Cl)cc3F)ncnc2cc1OC[C@@H]1CN2CCOCC2CO1
Show InChI InChI=1S/C23H23Cl2FN4O4/c1-31-21-4-15-19(27-12-28-23(15)29-20-6-17(25)16(24)5-18(20)26)7-22(21)34-11-14-8-30-2-3-32-9-13(30)10-33-14/h4-7,12-14H,2-3,8-11H2,1H3,(H,27,28,29)/t13?,14-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351329
PNG
(1,4:3,6-dianhydro-2-O-methyl-5-O-{6- (methyloxy)-4...)
Show SMILES CO[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3Cl)c2cc1OC
Show InChI InChI=1S/C22H20Cl3N3O5/c1-29-14-5-10-13(6-15(14)33-17-8-32-20-16(30-2)7-31-21(17)20)26-9-27-22(10)28-12-4-3-11(23)18(24)19(12)25/h3-6,9,16-17,20-21H,7-8H2,1-2H3,(H,26,27,28)/t16-,17-,20+,21+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351301
PNG
(N-(4-bromo-2,3-dichlorophenyl)-7-{[(3S,9aS)- hexah...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3Cl)ncnc2cc1OC[C@@H]1CN2CCOCC2CO1
Show InChI InChI=1S/C23H23BrCl2N4O4/c1-31-19-6-15-18(27-12-28-23(15)29-17-3-2-16(24)21(25)22(17)26)7-20(19)34-11-14-8-30-4-5-32-9-13(30)10-33-14/h2-3,6-7,12-14H,4-5,8-11H2,1H3,(H,27,28,29)/t13?,14-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351307
PNG
(N-(3-chloro-2,4-difluorophenyl)-7-{[(3S,8aS)- hexa...)
Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN2CCC[C@H]2CO1
Show InChI InChI=1S/C23H23ClF2N4O3/c1-31-19-7-15-18(8-20(19)33-11-14-9-30-6-2-3-13(30)10-32-14)27-12-28-23(15)29-17-5-4-16(25)21(24)22(17)26/h4-5,7-8,12-14H,2-3,6,9-11H2,1H3,(H,27,28,29)/t13-,14-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351308
PNG
(N-(4-bromo-2,3-dichlorophenyl)-7-{[(3S,8aS)- hexah...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3Cl)ncnc2cc1OC[C@@H]1CN2CCC[C@H]2CO1
Show InChI InChI=1S/C23H23BrCl2N4O3/c1-31-19-7-15-18(8-20(19)33-11-14-9-30-6-2-3-13(30)10-32-14)27-12-28-23(15)29-17-5-4-16(24)21(25)22(17)26/h4-5,7-8,12-14H,2-3,6,9-11H2,1H3,(H,27,28,29)/t13-,14-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351356
PNG
(1,4:3,6-dianhydro-2-O-[4-[(3-chloro-2- methylpheny...)
Show SMILES CO[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3cccc(Cl)c3C)c2cc1OC
Show InChI InChI=1S/C23H24ClN3O5/c1-12-14(24)5-4-6-15(12)27-23-13-7-17(28-2)18(8-16(13)25-11-26-23)32-20-10-31-21-19(29-3)9-30-22(20)21/h4-8,11,19-22H,9-10H2,1-3H3,(H,25,26,27)/t19-,20-,21+,22+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHA2)


(Homo sapiens (Human))
BDBM351358
PNG
(1,4:3,6-dianhydro-2-O-[4-[(4-bromo-3- chlorophenyl...)
Show SMILES CO[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3ccc(Br)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H21BrClN3O5/c1-28-16-6-12-15(25-10-26-22(12)27-11-3-4-13(23)14(24)5-11)7-17(16)32-19-9-31-20-18(29-2)8-30-21(19)20/h3-7,10,18-21H,8-9H2,1-2H3,(H,25,26,27)/t18-,19+,20-,21-/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351362
PNG
(US9796704, Entry 82 | methyl 3,6-anhydro-5-O-[4-[(...)
Show SMILES CO[C@H]1O[C@@H]2[C@H](CO[C@@H]2[C@H]1OC)Oc1cc2ncnc(Nc3ccc(Br)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C23H23BrClN3O6/c1-29-16-7-12-15(26-10-27-22(12)28-11-4-5-13(24)14(25)6-11)8-17(16)33-18-9-32-20-19(18)34-23(31-3)21(20)30-2/h4-8,10,18-21,23H,9H2,1-3H3,(H,26,27,28)/t18-,19+,20-,21+,23-/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351367
PNG
(1,4:3,6-dianhydro-2-deoxy-5-O-[4-[(2,6- difluoroph...)
Show SMILES COc1cc2c(Nc3c(F)cccc3F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18F3N3O4/c1-28-15-5-10-14(6-16(15)31-17-8-30-19-13(24)7-29-20(17)19)25-9-26-21(10)27-18-11(22)3-2-4-12(18)23/h2-6,9,13,17,19-20H,7-8H2,1H3,(H,25,26,27)/t13-,17-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351550
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-({[4- (3-ph...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(CCCc2ccccc2)CCO1
Show InChI InChI=1S/C29H30Cl2N4O3/c1-36-27-15-23-26(32-19-33-29(23)34-21-9-10-24(30)25(31)14-21)16-28(27)38-18-22-17-35(12-13-37-22)11-5-8-20-6-3-2-4-7-20/h2-4,6-7,9-10,14-16,19,22H,5,8,11-13,17-18H2,1H3,(H,32,33,34)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351554
PNG
(2-({2-[2-({[4-[(3,4-dichlorophenyl)amino]-6- (meth...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(CCOCCO)CCO1
Show InChI InChI=1S/C24H28Cl2N4O5/c1-32-22-11-18-21(27-15-28-24(18)29-16-2-3-19(25)20(26)10-16)12-23(22)35-14-17-13-30(5-8-34-17)4-7-33-9-6-31/h2-3,10-12,15,17,31H,4-9,13-14H2,1H3,(H,27,28,29)
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351313
PNG
(1,4:3,6-dianhydro-5-({[4-[(4-bromo-3-chloro- 2-flu...)
Show SMILES CO[C@H]1CO[C@@H]2C(COc3cc4ncnc(Nc5ccc(Br)c(Cl)c5F)c4cc3OC)CO[C@H]12
Show InChI InChI=1S/C23H22BrClFN3O5/c1-30-16-5-12-15(27-10-28-23(12)29-14-4-3-13(24)19(25)20(14)26)6-17(16)32-7-11-8-33-22-18(31-2)9-34-21(11)22/h3-6,10-11,18,21-22H,7-9H2,1-2H3,(H,27,28,29)/t11?,18-,21+,22+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351317
PNG
((3S,8aR)-3-({[4-[(3,4-dichloro-2- fluorophenyl)ami...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN2CCC[C@@H]2C(=O)N1
Show InChI InChI=1S/C23H22Cl2FN5O3/c1-33-18-7-13-16(27-11-28-22(13)30-15-5-4-14(24)20(25)21(15)26)8-19(18)34-10-12-9-31-6-2-3-17(31)23(32)29-12/h4-5,7-8,11-12,17H,2-3,6,9-10H2,1H3,(H,29,32)(H,27,28,30)/t12-,17+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351370
PNG
(1,4:3,6-dianhydro-2-deoxy-5-O-[4-[(2,4- difluoroph...)
Show SMILES COc1cc2c(Nc3ccc(F)cc3F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18F3N3O4/c1-28-16-5-11-15(6-17(16)31-18-8-30-19-13(24)7-29-20(18)19)25-9-26-21(11)27-14-3-2-10(22)4-12(14)23/h2-6,9,13,18-20H,7-8H2,1H3,(H,25,26,27)/t13-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351374
PNG
(1,4:3,6-dianhydro-2-deoxy-5-O-[4-[(3,5- difluoroph...)
Show SMILES COc1cc2c(Nc3cc(F)cc(F)c3)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18F3N3O4/c1-28-16-5-13-15(6-17(16)31-18-8-30-19-14(24)7-29-20(18)19)25-9-26-21(13)27-12-3-10(22)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,25,26,27)/t14-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHA2)


(Homo sapiens (Human))
BDBM351376
PNG
(1,4:3,6-dianhydro-5-O-[4-[(4-bromo-2- chlorophenyl...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3Cl)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18BrClFN3O4/c1-28-16-5-11-15(6-17(16)31-18-8-30-19-13(24)7-29-20(18)19)25-9-26-21(11)27-14-3-2-10(22)4-12(14)23/h2-6,9,13,18-20H,7-8H2,1H3,(H,25,26,27)/t13-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351326
PNG
(1,4:3,6-dianhydro-2-O-[4-[(4-bromo-5-chloro- 2-flu...)
Show SMILES CO[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3cc(Cl)c(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C22H20BrClFN3O5/c1-29-16-3-10-14(6-17(16)33-19-8-32-20-18(30-2)7-31-21(19)20)26-9-27-22(10)28-15-5-12(24)11(23)4-13(15)25/h3-6,9,18-21H,7-8H2,1-2H3,(H,26,27,28)/t18-,19-,20+,21+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351386
PNG
(1,4:3,6-dianhydro-2-deoxy-2-fluoro-5-O-{6- (methyl...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3Cl)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H17Cl3FN3O4/c1-29-14-4-9-13(5-15(14)32-16-7-31-19-11(25)6-30-20(16)19)26-8-27-21(9)28-12-3-2-10(22)17(23)18(12)24/h2-5,8,11,16,19-20H,6-7H2,1H3,(H,26,27,28)/t11-,16-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351387
PNG
(1,4:3,6-dianhydro-2-deoxy-2-fluoro-5-O-{6- (methyl...)
Show SMILES COc1cc2c(Nc3cc(Cl)c(Cl)c(Cl)c3)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H17Cl3FN3O4/c1-29-15-4-10-14(5-16(15)32-17-7-31-19-13(25)6-30-20(17)19)26-8-27-21(10)28-9-2-11(22)18(24)12(23)3-9/h2-5,8,13,17,19-20H,6-7H2,1H3,(H,26,27,28)/t13-,17-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351388
PNG
(1,4:3,6-dianhydro-5-O-[4-[(4-bromo-2- fluorophenyl...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18BrF2N3O4/c1-28-16-5-11-15(6-17(16)31-18-8-30-19-13(24)7-29-20(18)19)25-9-26-21(11)27-14-3-2-10(22)4-12(14)23/h2-6,9,13,18-20H,7-8H2,1H3,(H,25,26,27)/t13-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (KDR)


(Homo sapiens (Human))
BDBM351389
PNG
(1,4:3,6-dianhydro-5-O-[4-[(4-chloro-2- fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18ClF2N3O4/c1-28-16-5-11-15(6-17(16)31-18-8-30-19-13(24)7-29-20(18)19)25-9-26-21(11)27-14-3-2-10(22)4-12(14)23/h2-6,9,13,18-20H,7-8H2,1H3,(H,25,26,27)/t13-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351389
PNG
(1,4:3,6-dianhydro-5-O-[4-[(4-chloro-2- fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18ClF2N3O4/c1-28-16-5-11-15(6-17(16)31-18-8-30-19-13(24)7-29-20(18)19)25-9-26-21(11)27-14-3-2-10(22)4-12(14)23/h2-6,9,13,18-20H,7-8H2,1H3,(H,25,26,27)/t13-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351331
PNG
(1,4:3,6-dianhydro-2-O-[4-[(4-bromo-2,3- dichloroph...)
Show SMILES CO[C@H]1CO[C@@H]2[C@H](CO[C@H]12)Oc1cc2ncnc(Nc3ccc(Br)c(Cl)c3Cl)c2cc1OC
Show InChI InChI=1S/C22H20BrCl2N3O5/c1-29-14-5-10-13(6-15(14)33-17-8-32-20-16(30-2)7-31-21(17)20)26-9-27-22(10)28-12-4-3-11(23)18(24)19(12)25/h3-6,9,16-17,20-21H,7-8H2,1-2H3,(H,26,27,28)/t16-,17-,20+,21+/m0/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351334
PNG
(N-(4-bromo-3-chloro-2-fluorophenyl)-7- ({[(3aR,5r,...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(C[C@H]2C1)C(C)C
Show InChI InChI=1S/C26H29BrClFN4O2/c1-14(2)33-10-16-6-15(7-17(16)11-33)12-35-23-9-21-18(8-22(23)34-3)26(31-13-30-21)32-20-5-4-19(27)24(28)25(20)29/h4-5,8-9,13-17H,6-7,10-12H2,1-3H3,(H,30,31,32)/t15-,16-,17+
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHB4)


(Homo sapiens (Human))
BDBM351399
PNG
(1,4:3,6-dianhydro-2-deoxy-5-O-[4-[(3,4- dichloroph...)
Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C21H18Cl2FN3O4/c1-28-16-5-11-15(6-17(16)31-18-8-30-19-14(24)7-29-20(18)19)25-9-26-21(11)27-10-2-3-12(22)13(23)4-10/h2-6,9,14,18-20H,7-8H2,1H3,(H,25,26,27)/t14-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Ephrin receptor (EPHA2)


(Homo sapiens (Human))
BDBM351407
PNG
(1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluorome...)
Show SMILES COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C22H18BrF4N3O4/c1-31-16-5-13-15(6-17(16)34-18-8-33-19-14(24)7-32-20(18)19)28-9-29-21(13)30-12-3-10(22(25,26)27)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,28,29,30)/t14-,18-,19+,20+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351335
PNG
(7-({[(3aR,5r,6aS)-2- acetyloctahydrocyclopenta[c]p...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(C[C@H]2C1)C(C)=O
Show InChI InChI=1S/C25H25BrClFN4O3/c1-13(33)32-9-15-5-14(6-16(15)10-32)11-35-22-8-20-17(7-21(22)34-2)25(30-12-29-20)31-19-4-3-18(26)23(27)24(19)28/h3-4,7-8,12,14-16H,5-6,9-11H2,1-2H3,(H,29,30,31)/t14-,15-,16+
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351338
PNG
(N-(4-bromo-3-chloro-2-fluorophenyl)-6- (methyloxy)...)
Show SMILES COc1cc2c(Nc3ccc(Br)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(C[C@H]2C1)S(C)(=O)=O
Show InChI InChI=1S/C24H25BrClFN4O4S/c1-34-20-7-16-19(28-12-29-24(16)30-18-4-3-17(25)22(26)23(18)27)8-21(20)35-11-13-5-14-9-31(36(2,32)33)10-15(14)6-13/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13-,14-,15+
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR)


(Homo sapiens (Human))
BDBM351412
PNG
(1,4:3,6-dianhydro-5-O-[4-[(5-chloro-2- methylpheny...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3C)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12
Show InChI InChI=1S/C22H21ClFN3O4/c1-11-5-12(23)3-4-15(11)27-22-13-6-17(28-2)18(7-16(13)25-10-26-22)31-19-9-30-20-14(24)8-29-21(19)20/h3-7,10,14,19-21H,8-9H2,1-2H3,(H,25,26,27)/t14-,19-,20+,21+/m1/s1
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SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)

More data for this
Ligand-Target Pair
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