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Patent code US9796706

Compile Data Set for Download or QSAR

Found 505 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351602
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1ccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2c1
Show InChI InChI=1S/C17H11BrFN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-3-2-10(19)5-9(12)1-4-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351649
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3ccncc3ccc2=O)c1-c1ncn[nH]1
Show InChI InChI=1S/C16H11BrN6O2S/c17-10-7-26-16(14(10)15-19-8-20-22-15)21-12(24)6-23-11-3-4-18-5-9(11)1-2-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351653
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3cccnc3ccc2=O)c1-c1ncn[nH]1
Show InChI InChI=1S/C16H11BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351654
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3cnccc23)c1-c1ncn[nH]1
Show InChI InChI=1S/C16H13BrN6O2S/c17-10-7-26-16(14(10)15-19-8-20-22-15)21-12(24)6-23-11-3-4-18-5-9(11)1-2-13(23)25/h3-5,7-8H,1-2,6H2,(H,21,24)(H,19,20,22)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351659
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3sc(Cl)cc3-c3ncn[nH]3)c(=O)ccc2c1
Show InChI InChI=1S/C18H11ClF3N5O2S/c19-13-6-11(16-23-8-24-26-16)17(30-13)25-14(28)7-27-12-3-2-10(18(20,21)22)5-9(12)1-4-15(27)29/h1-6,8H,7H2,(H,25,28)(H,23,24,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351668
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES FC(F)(F)c1cccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc12
Show InChI InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-1-2-10(18(20,21)22)9(12)4-5-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351672
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1cc(CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c2cccnc2c1
Show InChI InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)5-9-4-10(19)6-13-11(9)2-1-3-20-13/h1-4,6-8H,5H2,(H,23,25)(H,21,22,24)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351676
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#C)c1-c1ncn[nH]1
Show InChI InChI=1S/C19H12BrN5O2S/c1-2-11-3-5-14-12(7-11)4-6-16(27)25(14)8-15(26)23-19-17(13(20)9-28-19)18-21-10-22-24-18/h1,3-7,9-10H,8H2,(H,23,26)(H,21,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351677
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2cn1
Show InChI InChI=1S/C17H10BrF3N6O2S/c18-9-6-30-16(14(9)15-23-7-24-26-15)25-12(28)5-27-10-3-11(17(19,20)21)22-4-8(10)1-2-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,23,24,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351678
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3ccnn3ccc2=O)c1-c1ncn[nH]1
Show InChI InChI=1S/C14H10BrN7O2S/c15-8-6-25-14(12(8)13-16-7-17-20-13)19-9(23)5-21-10-1-3-18-22(10)4-2-11(21)24/h1-4,6-7H,5H2,(H,19,23)(H,16,17,20)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351678
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3ccnn3ccc2=O)c1-c1ncn[nH]1
Show InChI InChI=1S/C14H10BrN7O2S/c15-8-6-25-14(12(8)13-16-7-17-20-13)19-9(23)5-21-10-1-3-18-22(10)4-2-11(21)24/h1-4,6-7H,5H2,(H,19,23)(H,16,17,20)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351682
PNG
(N-(4-cyano-3-(pyrazin-2-yl)thiophen-2-yl)-2-(quino...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1cnccn1
Show InChI InChI=1S/C20H13N5OS/c21-10-14-12-27-20(19(14)17-11-22-7-8-24-17)25-18(26)9-13-3-1-5-16-15(13)4-2-6-23-16/h1-8,11-12H,9H2,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50352626
PNG
(CHEMBL1822307 | US9796706, Compound 131)
Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1
Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM50352627
PNG
(CHEMBL1822308 | US9796706, Compound 134)
Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3nccs3)c(=O)ccc2c1
Show InChI InChI=1S/C20H11F3N4O2S2/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351694
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2cc1C(F)(F)F
Show InChI InChI=1S/C18H10BrF4N5O2S/c19-10-6-31-17(15(10)16-24-7-25-27-16)26-13(29)5-28-12-4-11(20)9(18(21,22)23)3-8(12)1-2-14(28)30/h1-4,6-7H,5H2,(H,26,29)(H,24,25,27)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351699
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1cc2ccncc2cc1CC(=O)Nc1scc(Br)c1-n1nccn1
Show InChI InChI=1S/C17H11BrFN5OS/c18-13-9-26-17(16(13)24-21-3-4-22-24)23-15(25)7-11-5-12-8-20-2-1-10(12)6-14(11)19/h1-6,8-9H,7H2,(H,23,25)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM50352625
PNG
(CHEMBL1822306 | US9796706, Compound 146)
Show SMILES O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nccs1
Show InChI InChI=1S/C18H13N5O2S2/c19-8-11-10-27-18(16(11)17-21-6-7-26-17)22-14(24)9-23-13-2-1-5-20-12(13)3-4-15(23)25/h1-2,5-7,10H,3-4,9H2,(H,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50352623
PNG
(CHEMBL1822154 | US9796706, Compound 150)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nccs1
Show InChI InChI=1S/C17H13BrN4O2S2/c18-10-9-26-17(15(10)16-20-6-7-25-16)21-13(23)8-22-12-2-1-5-19-11(12)3-4-14(22)24/h1-2,5-7,9H,3-4,8H2,(H,21,23)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351709
PNG
(N-(4-chloro-3-(3-methyl-1H-1,2,4-triazol-5-yl)thio...)
Show SMILES Cc1n[nH]c(n1)-c1c(Cl)csc1NC(=O)CN1C(=O)CCc2ncccc12
Show InChI InChI=1S/C17H15ClN6O2S/c1-9-20-16(23-22-9)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8H,4-5,7H2,1H3,(H,21,25)(H,20,22,23)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351713
PNG
(N-(4-chloro-3-(1-(2-(dimethylamino)ethyl)-1H-1,2,4...)
Show SMILES CN(C)CCn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccc(cc2ccc1=O)C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N6O2S/c1-30(2)7-8-31-12-27-20(29-31)19-15(23)11-35-21(19)28-17(33)10-32-16-5-4-14(22(24,25)26)9-13(16)3-6-18(32)34/h3-6,9,11-12H,7-8,10H2,1-2H3,(H,28,33)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351725
PNG
(2-(6-bromo-2-oxoquinolin-1(2H)-yl)-N-(4-bromo-3-(1...)
Show SMILES Brc1csc(NC(=O)Cn2c3ccc(Br)cc3ccc2=O)c1-c1nc[nH]n1
Show InChI InChI=1S/C17H11Br2N5O2S/c18-10-2-3-12-9(5-10)1-4-14(26)24(12)6-13(25)22-17-15(11(19)7-27-17)16-20-8-21-23-16/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351732
PNG
(N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thio...)
Show SMILES Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2cc(ncc2ccc1=O)C(F)(F)F
Show InChI InChI=1S/C18H12ClF3N6O2S/c1-27-8-24-16(26-27)15-10(19)7-31-17(15)25-13(29)6-28-11-4-12(18(20,21)22)23-5-9(11)2-3-14(28)30/h2-5,7-8H,6H2,1H3,(H,25,29)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351589
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351592
PNG
(N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1ncn[nH]1
Show InChI InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351598
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1
Show InChI InChI=1S/C17H11BrFN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-5-10(19)3-1-9(12)2-4-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351598
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1
Show InChI InChI=1S/C17H11BrFN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-5-10(19)3-1-9(12)2-4-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM50332091
PNG
(CHEMBL1288160 | N-(4,4'-bithiazol-5-yl)-2-(isoquin...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1
Show InChI InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351650
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1ccc(CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c2cccnc12
Show InChI InChI=1S/C17H11BrFN5OS/c18-11-7-26-17(14(11)16-21-8-22-24-16)23-13(25)6-9-3-4-12(19)15-10(9)2-1-5-20-15/h1-5,7-8H,6H2,(H,23,25)(H,21,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351650
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1ccc(CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c2cccnc12
Show InChI InChI=1S/C17H11BrFN5OS/c18-11-7-26-17(14(11)16-21-8-22-24-16)23-13(25)6-9-3-4-12(19)15-10(9)2-1-5-20-15/h1-5,7-8H,6H2,(H,23,25)(H,21,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351653
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3cccnc3ccc2=O)c1-c1ncn[nH]1
Show InChI InChI=1S/C16H11BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351653
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3cccnc3ccc2=O)c1-c1ncn[nH]1
Show InChI InChI=1S/C16H11BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351655
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1ncn[nH]1
Show InChI InChI=1S/C16H13BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-2,5,7-8H,3-4,6H2,(H,21,24)(H,19,20,22)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351662
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)...)
Show SMILES Fc1cnc2cccc(CC(=O)Nc3scc(Br)c3-c3nc[nH]n3)c2c1
Show InChI InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)4-9-2-1-3-13-11(9)5-10(19)6-20-13/h1-3,5-8H,4H2,(H,23,25)(H,21,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351596
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES FC(F)(F)c1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1
Show InChI InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-5-10(18(20,21)22)3-1-9(12)2-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351666
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#N)c1-c1ncn[nH]1
Show InChI InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-3-1-10(6-20)5-11(13)2-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351669
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES FC(F)(F)c1ccc2N(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)C(=O)CCc2c1
Show InChI InChI=1S/C18H13BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h2-3,5,7-8H,1,4,6H2,(H,25,28)(H,23,24,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351670
PNG
(N-(4-cyano-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiop...)
Show SMILES Cn1cnc(n1)-c1c(NC(=O)Cc2cccc3ncccc23)scc1C#N
Show InChI InChI=1S/C19H14N6OS/c1-25-11-22-18(24-25)17-13(9-20)10-27-19(17)23-16(26)8-12-4-2-6-15-14(12)5-3-7-21-15/h2-7,10-11H,8H2,1H3,(H,23,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351677
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2cn1
Show InChI InChI=1S/C17H10BrF3N6O2S/c18-9-6-30-16(14(9)15-23-7-24-26-15)25-12(28)5-27-10-3-11(17(19,20)21)22-4-8(10)1-2-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,23,24,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351686
PNG
(N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl...)
Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Cl)c3-c3ncn[nH]3)c(=O)ccc2c1
Show InChI InChI=1S/C18H11ClF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM50352626
PNG
(CHEMBL1822307 | US9796706, Compound 131)
Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1
Show InChI InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM351693
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3nccn23)c1-c1ncn[nH]1
Show InChI InChI=1S/C15H11BrN6OS/c16-10-7-24-15(13(10)14-18-8-19-21-14)20-12(23)6-9-2-1-3-11-17-4-5-22(9)11/h1-5,7-8H,6H2,(H,20,23)(H,18,19,21)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK1


(Homo sapiens (Human))
BDBM50352624
PNG
(CHEMBL1822305 | US9796706, Compound 139)
Show SMILES Cn1cnc(n1)-c1c(Br)csc1NC(=O)CN1C(=O)CCc2ncccc12
Show InChI InChI=1S/C17H15BrN6O2S/c1-23-9-20-16(22-23)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,25)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351699
PNG
(N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)...)
Show SMILES Fc1cc2ccncc2cc1CC(=O)Nc1scc(Br)c1-n1nccn1
Show InChI InChI=1S/C17H11BrFN5OS/c18-13-9-26-17(16(13)24-21-3-4-22-24)23-15(25)7-11-5-12-8-20-2-1-10(12)6-14(11)19/h1-6,8-9H,7H2,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351701
PNG
(N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl...)
Show SMILES Clc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nc[nH]n1
Show InChI InChI=1S/C16H13ClN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-2,5,7-8H,3-4,6H2,(H,21,24)(H,19,20,22)
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n/an/a<100n/an/an/an/an/an/a



IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50352625
PNG
(CHEMBL1822306 | US9796706, Compound 146)
Show SMILES O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nccs1
Show InChI InChI=1S/C18H13N5O2S2/c19-8-11-10-27-18(16(11)17-21-6-7-26-17)22-14(24)9-23-13-2-1-5-20-12(13)3-4-15(23)25/h1-2,5-7,10H,3-4,9H2,(H,22,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351710
PNG
(N-(4-chloro-3-(1-(3-(dimethylamino)propyl)-1H-1,2,...)
Show SMILES CN(C)CCCn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccc(cc2ccc1=O)C(F)(F)F
Show InChI InChI=1S/C23H22ClF3N6O2S/c1-31(2)8-3-9-32-13-28-21(30-32)20-16(24)12-36-22(20)29-18(34)11-33-17-6-5-15(23(25,26)27)10-14(17)4-7-19(33)35/h4-7,10,12-13H,3,8-9,11H2,1-2H3,(H,29,34)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351712
PNG
(N-(4-chloro-3-(3-ethyl-1H-1,2,4-triazol-5-yl)thiop...)
Show SMILES CCc1n[nH]c(n1)-c1c(Cl)csc1NC(=O)CN1C(=O)CCc2ncccc12
Show InChI InChI=1S/C18H17ClN6O2S/c1-2-13-21-17(24-23-13)16-10(19)9-28-18(16)22-14(26)8-25-12-4-3-7-20-11(12)5-6-15(25)27/h3-4,7,9H,2,5-6,8H2,1H3,(H,22,26)(H,21,23,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351716
PNG
(N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thio...)
Show SMILES Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccnn2ccc1=O
Show InChI InChI=1S/C15H12ClN7O2S/c1-21-8-17-14(20-21)13-9(16)7-26-15(13)19-10(24)6-22-11-2-4-18-23(11)5-3-12(22)25/h2-5,7-8H,6H2,1H3,(H,19,24)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9 (JNK2)


(Homo sapiens (Human))
BDBM351717
PNG
(N-(4-chloro-3-(1-(3-morpholinopropyl)-1H-1,2,4-tri...)
Show SMILES FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Cl)c3-c3ncn(CCCN4CCOCC4)n3)c(=O)ccc2c1
Show InChI InChI=1S/C25H24ClF3N6O3S/c26-18-14-39-24(22(18)23-30-15-34(32-23)7-1-6-33-8-10-38-11-9-33)31-20(36)13-35-19-4-3-17(25(27,28)29)12-16(19)2-5-21(35)37/h2-5,12,14-15H,1,6-11,13H2,(H,31,36)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM351726
PNG
(N-(4-cyano-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiop...)
Show SMILES Cn1cnc(n1)-c1c(NC(=O)CN2C(=O)CCc3ncccc23)scc1C#N
Show InChI InChI=1S/C18H15N7O2S/c1-24-10-21-17(23-24)16-11(7-19)9-28-18(16)22-14(26)8-25-13-3-2-6-20-12(13)4-5-15(25)27/h2-3,6,9-10H,4-5,8H2,1H3,(H,22,26)
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IMAGO PHARMACEUTICALS, INC.

US Patent


Assay Description
(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...


US Patent US9796706 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%